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From Bait To Breakthrough: How Polychaetes Are Revolutionizing Philippine Aquaculture, Janice A. Ragaza, Irnes Rebien H. Bailon, Rochelle A. Jabines

Biology Faculty Publications

No abstract provided.

Ptp1b Inhibitors Of Marine Sponge-Derived Secondary Metabolites From Dysidea, Irvin B. Rondolo, G. A. Lasam, M. N. Aguila, A. J. De Jesus

Biology Faculty Publications

Diabetes is a chronic metabolic disease with high morbidity and mortality due to its complications. Recently, there has been growing interest in identifying new bioactive compounds, including marinederived secondary metabolites, for potential antidiabetic activities. This study focuses on secondary metabolites from marine sponges from the genus Dysidea that show strong inhibition of protein tyrosine phosphatase 1B (PTP1B), a key target in antidiabetic therapy. Thirteen out of the thirty-one compounds were identified to have promising in silico potentials vs PTP1B: avarol (1), avarone (2), furodysin (3), nakafuran 8 (4), haterumadysin A (5), pyrodysinoic acid (6), avinosol (7), puupehenone (8), α-santonin (9), …

Understanding The Mechanism In Shaping Guest Acceptance Of Service Robots In Caribbean Hotels: The Moderating Role Of Cultural Familiarity In The Cac Model, Jamilia A. Lawrence

Graduate Thesis and Dissertation post-2024

Service robots continue to become increasingly popular in the hospitality and tourism industry. Understanding the cognitive and emotional processes is important in explaining the sequential processes of guests accepting new technologies. Especially in regions like the Caribbean, where human-to-human interaction and personalized services are highly valued.

This study investigates how cognitive evaluations of service robots, including utility, coolness, autonomy, courtesy, and interactivity, influence guests' emotional responses and their acceptance of the technology in Caribbean hotels. Additionally, the study explores the moderating role of cultural familiarity in the relationship between emotion and acceptance.

Using the cognitive-affective-conative (CAC) model, 415 responses were …

Transformative Experience Design: Exploring The Supply-Side Perspective In The Theme Park Context, Juliana Rodrigues Vieira Tkatch

Graduate Thesis and Dissertation post-2024

This study investigates how hedonic tourism activities can facilitate personal transformation, particularly in the context of mass tourism. Focusing on theme parks, which draw millions of visitors annually, the research explores the design elements that can foster visitor transformation. The study aims to uncover the design elements embedded in the creation of these activities and the effects they intend to foster in visitors, answering the research question: How do theme park design practices contribute to transformative tourism experiences? This question is significant given the limited empirical work connecting experience design and transformative tourism from the supplier perspective. Using a qualitative …

Inhibition Of Activin A Signaling Slows The Progression Of Barrett's Esophagus Induced Esophageal Adenocarcinoma, Lily A. Giardino

Graduate Thesis and Dissertation post-2024

In 2020, approximately 1.03 billion cases of Gastro-esophageal Reflux Disease (GERD) were reported worldwide, representing a significant global health burden. Chronic GERD is a potent initiator of Barrett’s Esophagus (BE), a precancerous condition in which the squamous epithelium is converted into columnar-like epithelium in the distal esophagus in response to reflux injury. Barrett’s Esophagus is the only known precursor to Esophageal Adenocarcinoma (EAC), a disease with a five-year survival rate of 21%. First line treatments focus on acid suppression and endoscopic mucosal resection but did not result in a decrease of EAC incidence highlighting the importance of new therapeutics. Previous …

Multi-Omics Analysis Of Streptococcus Pneumoniae Serotype 3 Using A Murine Infection Model, Jash Kamlesh Trivedi

Graduate Thesis and Dissertation post-2024

Streptococcus pneumoniae (SPN), a gram-positive encapsulated pathogen, inhabits the human nasopharynx asymptomatically but can cause severe infections, including invasive pneumococcal diseases (IPD). Although targeted by vaccines, serotype 3 (ST3) remains highly prevalent within the United States and globally. Sequence type 180 lineage within Clonal Complex (CC)180 is the predominant lineage of serotype 3 globally. Genetically, Clonal Complex 180 is divided into clade I and II, with clade II recently surpassing clade I in prevalence. However, the molecular mechanisms driving this shift remain poorly understood. Here, we employ a multi-omics approach, combining pangenome analysis and dual-RNA sequencing, to investigate genetic factors …

Cigarettes, Flesh, & Other Cravings, Gabrielle F. Decker

Graduate Thesis and Dissertation post-2024

Cigarettes, Flesh, & Other Cravings is a collection of short stories that explores themes of motherhood, death, and desire. Each character struggles with the friction between society's expectations and their desires for happiness, all through the lens of the surreal and the absurd. A destructive raccoon’s nightly visits unravel a woman’s sense of control. A teenager begins an internship with a conspiracy-obsessed clown. A minuscule old woman tumbles out of a chicken egg. A fissure in a kitchen floor births an imp. A Choose Your Own Adventure examines the illusion of choice. In Hell, torture is personalized. Cigarettes, Flesh, & …

The Multifaceted Roles Of Propionic Acid In Autism Spectrum Disorder And Crohn’S Disease, Piotr P. Lagod

Graduate Thesis and Dissertation post-2024

Short chain fatty acids (SCFAs), including propionic (PPA) and butyric (BA) acid, exert a variable and organ-specific effect on the body. They are by-products of human microbiota metabolism and are often used as a food preservative. Studies have shown that PPA and its producers are elevated in autism spectrum disorder (ASD) patients and their mothers. Our lab previously demonstrated that PPA alters neural stem cell differentiation in favor of glia. In this work, we utilized an in vivo mice model, in which dams and their offspring were fed a PPA-rich diet. In the brain, we observed a significant increase in …

Designing Immersive Educational Experiences: An Exploration Of Animal Attractions And Exhibits To Create A National Park Themed Experience, Sarah G. Merrill

Graduate Thesis and Dissertation post-2024

This thesis analyzes the disconnect between immersive environmental storytelling and conservation education at animal attractions. How can designers create immersive educational experiences that engage audiences? Can environmental narrative practices be applied in a new way to develop effective conservation and wildlife education? A literature review assists in defining immersion, discovering the evolution of Modern Zoo design as an immersive experience, and evaluating conversation education in animal facilities. When combined with educational techniques, immersive habitat design improves guest engagement and informal conservation learning outcomes in zoos and animal-related experiences. Using Scott Lukas’ theming and immersion modes, three attractions are analyzed as …

I'M Sorry You Have To Read This, Mark Blok

Graduate Thesis and Dissertation post-2024

I’m Sorry You Have to Read This is a collection of essays that explore Russian culture, Jewish traditions, and American identity. Through reflections on illness, the indignities of premature balding, and the ongoing puzzle of cultural belonging, these essays navigate the awkward and absurd passage from childhood to adulthood. The first essay, “Traditions Schmaditions,” explores cultural identity, assimilation, and generational inheritance within a Russian-Jewish immigrant family. At its core, it’s about obligation and fear, and the struggle to break free from traditions kept out of habit rather than intention. Following essays of culture-shaping experiences that explore learning to define adulthood …

Drag In Theme Parks: An Application Of Queer Theory And Intergroup Contact Theory, Corey D. Clancy

Graduate Thesis and Dissertation post-2024

The intent of this paper is to evaluate whether the artistic expression of Drag can be understood and appreciated by its critics when employed at Theme Parks. This will be accomplished through the lenses and applications of Queer Theory and Intergroup Contact Theory by researching what the art of Drag is, defining its different expressions, interviewing members of the Drag community, and creating clear guidelines and “Criteria for Drag in Theme Parks.”

With such passionate feelings on Drag in culture today, this research will aim to take subjectivity out of the matter and focus objectively on the impacts that Drag …

& Everything Else, Ian R. Abercrombie

Graduate Thesis and Dissertation post-2024

& EVERYTHING ELSE is a collection of stories that explores various forms of obsession. In “BEG FOR SCRAPS,” Pickle, a former bomb-sniffing dog, fixates on his owner, who’s fallen into a cycle of neglect post-divorce. “LET THEM FIGHT” follows Casey, a 20-something on a date to see, for the umpteenth time, a kaiju movie that conjures their escapist tendencies from a traumatic childhood. “DINNER WITH THE FOOL,” narrated by a state-appointed clown obsessed with jokes, describes a family contending with their matriarch’s planned suicide. “BIRDWATCHING” follows three characters, each with their own odd obsession: Jodie who wants to photograph a …

Bent Never Broken: A Study Of Multidimensional Perfectionism Through Animation, Sabrina R. Dias

Graduate Thesis and Dissertation post-2024

Bent Never Broken is a 3D animated short film about a martial artist that strives to gain his mother’s love through perfection. The film focuses on maladaptive multidimensional perfectionism and how it affects parent-child relationships. Bent Never Broken utilizes stylized rendering and animation to maintain maturity and appeal. It has a mature storyline with an ending that enforces the idea that perfection does not equate to love, and that it is okay to walk away from maladjusted parent-child relationships.

The Transition Of Tradition: The Modernismo Era Of Puerto Rican Postcolonial Short Fiction, Natalie Donis

Graduate Thesis and Dissertation post-2024

Modernismo, an artistic and literary cultural movement that swept across Latin America, profoundly shaped Puerto Rican short fiction by introducing innovative narrative techniques before the novel gained prominence on the island. Emerging during the sociopolitical upheaval following the Spanish American War and Puerto Rico's annexation by the United States, modernismo responded to both European artistic trends and the cultural tensions of colonial transition. In my research, in Puerto Rico, Moderismo emerged in the short story before the novel. This research examines how Puerto Rican short stories by José Luis González and Emilio Díaz Valcárcel, from this era, grapple with themes …

Catching Light Finding Encouragement Through Art And The Role Of Women In Impressionism, Vlada Evtushenko

Graduate Thesis and Dissertation post-2024

Catching Light is a two-dimensional (2D) animated film about the importance of human connection through the tale of an artist rediscovering their passion for painting through the support of a fellow artist. Catching Light is told through the lens of the period in art history when the artists, who eventually came to be known as 'Impressionists', broke free from the traditions of the Academy. The story highlights how the Art Academy restricted and discriminated against people based on social class and gender, and its disrespect towards the craft of paintmaking. By setting this story in the late 19th century, Catching …

The Value Of Balance: Exploring Timelessness Of Narrative Styles And Character Dynamics Through Animation, Jessica Gray

Graduate Thesis and Dissertation post-2024

Dazzling: A Timekeepers Tale is a 2D/3D animated short film that explores timeless storytelling, perception of time, anthropomorphism, and friendship. The film illustrates the necessity for balance between curiosity and caution when striving to learn. Through the dual protagonists’ contrasting personalities, they reach a deeper understanding of each other, thus learning the value of balance. This theme was constructed around a fantasy space that will function as a means of understanding varying perceptions of time. Thesis research explores ideas of balance between traditional Western narrative structures such as the Hero’s Journey, Aesopic fables, and Buddy Comedy within a combination of …

Perezhivanie In Practice: Exploring Affective Memory And Imagination Through The Stanislavski System, Paige E. Mason

Graduate Thesis and Dissertation post-2024

This thesis explores the enduring significance of The Stanislavski System in modern American actor training, addressing why it remains essential over a century after its creation by Konstantin Stanislavski. While studying the history of how The Stanislavski System was introduced and adapted in America, I identified a fundamental divide that shaped actor training: Lee Strasberg emphasized affective memory to generate emotion, while Stella Adler advocated for imagination to connect with character. Their public dispute has had a lasting impact on American theatre pedagogy, often leaving actors caught between methodologies without a clear understanding of the System’s original intent. At the …

Development Of Human Neuronal Microphysiological Models And Subsequent Integration Into Multi-Organ Platforms For Evaluation Of Therapeutic Efficacy And Off-Target Toxicity, Aakash Patel

Graduate Thesis and Dissertation post-2024

Microphysiological systems are a rapidly growing field of research for modeling of physiological processes and disease in an in vitro environment. The translatability and cost effectiveness of these platforms make them a valuable tool for drug discovery, allowing investigation of both efficacy and off-target toxicity either as a replacement or supplement to traditional animal models. Neurological disorders in particular are often difficult to emulate in an animal model, making the development of these models a highly useful area of research for both elucidation of brain function, as well as neurological disorders. Taking these models and integrating them into a multi-organ …

The Girl Who Drowned The Whole World, Sophia Saco

Graduate Thesis and Dissertation post-2024

THE GIRL WHO DROWNED THE WHOLE WORLD investigates the consequences of loneliness. Upon returning to her hometown, the speaker, Cucú, reckons with the fact she no longer has a place amongst her friends and past. Her frustrations manifest as a Biblical flooding, leaving her the only person alive in the world. She embarks on a journey of coping whilst reframing her sudden penance as a baptism.

Through motifs of alchemy and Catholicism, hermit crab forms, and reflections on young adulthood, THE GIRL WHO DROWNED THE WHOLE WORLD contemplates how everyone can better themselves in difficult circumstances.

Written as prose poems, …

Application Of Multi-Branching Narratives And Cooperative Gaming For Theme Park Rides, Jon Bryan Salvador

Graduate Thesis and Dissertation post-2024

This thesis examines the opportunities to combine video game concepts such as branching narrative games and cooperative games with interactive theme park rides or attractions. With the state of the contemporary themed entertainment industry explicitly defining the guest’s role to the context of the ride or attraction’s storyworld, there is a need to reassess the conventional forms of theme park ride interactivity to create a more dynamic narrative, gameplay experience, and guest or audience engagement. Through a brief analysis of relevant themed experience and video game references, this research proposes a cooperative theme park ride that utilizes a modified version …

Nf-Κb-Mediated Oxidative Stress Drives Cigarette Smoke-Induced Emt In Human Bronchial Cells, Sarah M. Alqithami

Theses and Dissertations--Toxicology and Cancer Biology

Cigarette smoke contains over 7,000 chemicals, many being carcinogens and proinflammatory agents contributing to chronic respiratory diseases like COPD and lung cancer. This study investigated responses of human bronchial epithelial cells (HBECs) to cigarette smoke condensate (CSC), focusing on oxidative stress and NF-κB signaling. Three HBEC lines were exposed to non-cytotoxic CSC doses for 48 hours, inducing morphological changes consistent with epithelial-to-mesenchymal transition (EMT). RNA sequencing revealed transcriptomic shifts in all cell lines, particularly affecting genes related to oxidative stress, inflammation, hypoxia, and metabolism. Enrichment analyses confirmed activation of NRF2 antioxidant, NF-κB and IL-17 inflammatory, and hypoxiainducible factor pathways, indicating …

Elucidating The Adverse Effects Of Chronic Pfos Exposure On Gastrointestinal Pathology And Colorectal Cancer, Jerika Durham

Theses and Dissertations--Toxicology and Cancer Biology

Commonly referred to as "forever chemicals," per- and polyfluoroalkyl substances (PFAS) have been linked to a number of detrimental health effects, including an elevated risk of cancer. One "long-chain" subtype of PFAS, perfluorooctanesulfonic acid (PFOS), has a long elimination half-life and a significant propensity for bioaccumulation. Because PFOS is commonly found in drinking water, the gastrointestinal system absorbs it at a high rate. Recent studies demonstrate that PFAS exposures promote intestinal inflammation and gut barrier dysfunction. However, how a long-term PFOS exposure affects colorectal cancer (CRC) progression is not known. Therefore, the purpose of this research is to understand how …

Investigating Plk1 In Pulmonary Fibrosis, Tempany Arbogast

Theses and Dissertations--Toxicology and Cancer Biology

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease, with a median survival of only 2–3 years following diagnosis. In the United States, the disease contributes to more than 40,000 deaths annually, underscoring its severe clinical burden. Alveolar type II (AT2) lung epithelial cells serve as progenitors that maintain alveolar integrity by replenishing epithelial populations and producing surfactants, while fibroblasts and myofibroblasts regulate the extracellular matrix and structural support. In pulmonary fibrosis (PF) injury to AT2 cells promotes cytokine and growth factor release, driving inflammation, fibroblast proliferation, myofibroblast accumulation, and excessive extracellular matrix deposition. Aberrant AT2 cell …

Pfas Litigation And Industry “Science”: Combating Deceptive Industry Practices, Dayna Smith

Western New England Law Review

PFAS have become a hot spot of litigation due to their growing notoriety as one of the greatest chemical threats of our time. Yet, due to concerted efforts by the PFAS industry, PFAS cases are likely to face a significant hurdle in the courtroom. Historically, industry groups have funded studies to lend support to their products, leading to a high risk of bias that has potentially far-reaching consequences. Further, there is mounting evidence that the PFAS industry actively used funding to manipulate science, while also engaging in other deceptive practices to hide potential health risks. This industry “science” then makes …

Revolutionizing The Immaculate Conception: The Limitations Of Medieval Theology And The Advancements Of John Duns Scotus, Emily G. Knoppe

Graduate Theses/Dissertations

Although in the modern era, the Immaculate Conception is a controversial doctrine that prompts conflict primarily between Catholic and non-Catholic groups, during the medieval period Roman Catholics were greatly divided on the topic. Opposition to the belief hinges not only on its lack of scriptural basis and complicated theology, which some deem as placing Mary outside of the need for Christ’s redemption, but also on the fact that it was not declared dogma until 1854 by Pope Pius IX. In this thesis, I first consider how Augustine of Hippo’s original sin theology laid the foundation for avid rejection of the …

A Cadaver Story: Relationality In The Anatomy Laboratory, Stephanie Teasley

Graduate Theses/Dissertations

Cadavers in the human anatomy laboratory occupy a liminal social space, a circumstance that presents a variety of challenges for anatomy students. Cadavers are intended to be scientific objects for study, but their human status makes dissection uniquely challenging. Many of the obstacles to working in the laboratory result from discomfort experienced at the thought of cutting a person (i.e. a social being). In this project, I use ‘cadaver’ to indicate a category of being created in and for the anatomy laboratory. This is distinct from the more general ‘dead body’ in that the category cadaver enables emotional distance and …

Movement And Activity Of Burbot, (Mizay; Lota Lota) In A Spring-Fed Minnesota Lake, Abigail M. Fountain

Biology Graduate Theses

Burbot (Mizay; Lota lota) are a relatively unmanaged freshwater fish, important in many local Indigenous cultures, but often overlooked or maltreated in research, conservation, and fishing practices. As such, relatively little research has been conducted on Burbot, despite ecological significance as an indicator species. A recent resurgence in popularity as a target species, however, has prompted new research to inform management policies. The objectives of this study were to summarize Burbot movement by identifying patterns in swimming activity and identify possible predictors of the movement observed. This study investigated the movements of 39 individuals implanted with acoustic transmitters in Bad …

Trends In Science Outreach Research Through Social Media (2000-2023): A Comprehensive Bibliometric Analysis, María Del Pilar Quezada Castro, Marco Antonio Rodríguez Vega, María Del Pilar Castro Arellano, Guillermo Alexander Quezada Castro

Health Professions Education

Purpose: Scientific dissemination is key to transmitting specialized knowledge to society, using social networks and digital platforms as essential tools. This study aims to conduct a comprehensive bibliometric analysis to identify trends, key themes, and collaboration networks in scientific outreach research.

Methods: A bibliometric analysis of 1577 papers indexed in the Scopus database between 2000 and 2023 was conducted using advanced tools such as Biblioshiny and VOSviewer. The analysis focused on co-authorship patterns, citation networks, and emerging thematic trends.

Results: The findings showed exponential growth in scientific output over the last four years, shaped by the impact of the COVID-19 …

Vaccines And Publics: A Variety Of Engagement Experiences, David H. Lee

Publications and Research

This chapter is about some of the sites and scenes where members of the public are exposed to (and engage in) vaccination discourse. To preview, after a brief introduction, we begin with messaging models of communication, followed by the move from messaging to engagement. Next, case examples of public engagement with vaccines are introduced, from pandemic influenza preparedness in the U.S., to polio eradication initiatives in India, and then to COVID-19 public engagement events in England. Settings of public engagement are noted, including online, in churches and museums. Then, there’s a section about communication and public participation, seen as either …

An Analysis Of Htt Involvement In Huntington’S Disease, Elaine Vanterpool, Micah Andrews

Student Posters

Huntington's disease is a neurodegenerative disorder characterized by loss of striatal neurons. These striatal neurons are essential in cognition, motor function, decision-making, motivation, reinforcement, and reward perception. Affected individuals may show symptoms such as isolation, lack of motivation, depression, mood swings, and personality changes. This study’s purpose is to analyze and highlight the variants of the HTT gene in the pathogenesis of Huntington’s disease.