Digital Commons Network^™

Phase I Study Of Bms-986299, An Nlrp3 Agonist, As Monotherapy And In Combination With Nivolumab And Ipilimumab In Patients With Advanced Solid Tumors, Blessie E Nelson, Shaun O'Brien, Rahul A Sheth, David S Hong, Aung Naing, Xiaoping Zhang, Amy Xu, Lora Hamuro, Rasika Suryawanshi, Derrick Mckinley, Ruslan D Novosiadly, Sarina A Piha-Paul

Faculty, Staff and Student Publications

Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.

Materials and methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.

Results: 36 patients were enrolled, with breast (31%), colorectal (17%), and head and neck (14%) being the more commonly enrolled cancers. Most patients (58%) had received prior immunotherapy. Therapy was well-tolerated, with G1-G2 fever (70%), neutrophilia (36%), and leukocytosis …

Iwu Director Of Jazz Reginald Lewis Talks With Wglt About The Traveling Harlem Renaissance Exhibition Comes To Bloomington-Normal, Emily Bollinger

Interviews for WGLT

IWU Director of Jazz Reginald Lewis explains how African American art and culture during the Harlem Renaissance helped challenge harmful stereotypes while highlighting the skill and creativity of Black artists.

Protein Translation Rates Are Negatively Correlated With Lifespan In Inbred Drosophila Strains, Harper S Kim, Madison M Hardiman, Andrew M Pickering

Faculty, Staff and Student Publications

No abstract provided.

Investigating The Correlation Between Racially Based Trauma And The Imposter Phenomenon In High-Achieving Black Women, Tarra Lynn Winfield Ray

Doctoral Dissertations and Projects

This study investigates the imposter phenomenon, racially based trauma, and how the two correlate among high-achieving Black women. High achieving for this writing refers to Black women who attend college or graduate school, those in professional positions that require a degree, advanced degree, or professional licensure (i.e., corporate executives, medical doctors, attorneys, mental health clinicians, etc.), and entrepreneurs. Many current studies have focused on the unique and complex experiences that high-achieving Black women face while working to achieve goals and gain success. Many of these women have experienced racially based trauma, and many endorse the simultaneous experiencing of the imposter …

Technology-As-Instrument: A Case Study Of Undergraduate Student Experience With Daw Technology, Brian Coski

Doctoral Dissertations and Projects

Within the typical music appreciation class, diverse subsections of students exhibit varying levels of experience that can result in challenging inequities in engagement and comprehension. For those students with no background in playing an instrument or singing, musical ideas often need more context and perspective. Technology can present an opportunity for all students to explore the elements of music by utilizing music production software as a virtual instrument. In this study, the researcher utilized curriculum strategies specifically designed to foster deep musical connection through a technology-as-instrument approach. Through informal learning and the tools of music production, students visualized and interacted …

What Hath Jerusalem To Do With Chile: Towards An Evangelical Understanding Of The Enneagram And Its Usage For Spiritual Development, Wesley E. Scholtz

Doctoral Dissertations and Projects

Currently, it is estimated that the personality testing market is worth approximately $2 billion. The Church has expressed interest in understanding personality types through various testing methods. The Enneagram offers a possibly ancient method to help people understand who they are in a spiritual capacity, which can be an aid in connecting more closely with God. This dissertation addressed the research gap that exists within the current literature which is the lack of data concerning whether adults who are professional, ordained ministers are aware of, use, and may be skeptical of the Enneagram. The research method in this dissertation was …

Molecular Determinants Of Condensate Composition, Alex S Holehouse, Simon Alberti

2020-Current year OA Pubs

Cells use membraneless compartments to organize their interiors, and recent research has begun to uncover the molecular principles underlying their assembly. Here, we explore how site-specific and chemically specific interactions shape the properties and functions of condensates. Site-specific recruitment involves precise interactions at specific sites driven by partially or fully structured interfaces. In contrast, chemically specific recruitment is driven by complementary chemical interactions without the requirement for a persistent bound-state structure. We propose that site-specific and chemically specific interactions work together to determine the composition of condensates, facilitate biochemical reactions, and regulate enzymatic activities linked to metabolism, signaling, and gene …

A Yeast-Based Oral Therapeutic Delivers Immune Checkpoint Inhibitors To Reduce Intestinal Tumor Burden, Olivia N Rebeck, Miranda J Wallace, Jerome Prusa, Jie Ning, Esse M Evbuomwan, Sunaina Rengarajan, Lemoyne Habimana-Griffin, Suryang Kwak, David Zahrah, Jason Tung, James Liao, Bejan Mahmud, Skye R S Fishbein, Erick S Ramirez Tovar, Rehan Mehta, Bin Wang, Mark G Gorelik, Gautam Dantas, Et Al.

2020-Current year OA Pubs

Engineered probiotics are an emerging platform for in situ delivery of therapeutics to the gut. Herein, we developed an orally administered, yeast-based therapeutic delivery system to deliver next-generation immune checkpoint inhibitor (ICI) proteins directly to gastrointestinal tumors. We engineered Saccharomyces cerevisiae var. boulardii (Sb), a probiotic yeast with high genetic tractability and innate anticancer activity, to secrete "miniature" antibody variants that target programmed death ligand 1 (Sb_haPD-1). When tested in an ICI-refractory colorectal cancer (CRC) mouse model, Sb_haPD-1 significantly reduced intestinal tumor burden and resulted in significant shifts to the immune cell profile and microbiome composition. This oral therapeutic platform …

Sex Differences In Response To Diet Enriched With Glutathione Precursors In The Aging Heart, Aude Angelini, Grecia Garcia Marquez, Anna Malovannaya, Marta L Fiorotto, Alexander Saltzman, Antrix Jain, Joann Trial, George E Taffet, Katarzyna A Cieslik

Faculty, Staff and Students Publications

Common features of the aging heart are dysregulated metabolism, inflammation, and fibrosis. Elevated oxidative stress is another hallmark of cardiac aging that can exacerbate each of these conditions. We hypothesize that by increasing natural antioxidant levels (glutathione), we will improve cardiac function. Twenty-one-month-old mice were fed glycine and N-acetyl cysteine (GlyNAC; glutathione precursors)-supplemented or control diets for 12 weeks. Heart function was monitored longitudinally, and the exercise performance was determined at the end of the study. We found that the GlyNAC diet was beneficial for old male but not old female mice, leading to an increase of Ndufb8 expression (a …

Preformulation Study Of Kigelia Africana Fruit Ethanolic Extract As Topical Preparations, Tareq Maqlam, Abdullah H Maad, Mohammed E Shayoub, Zuheir Osman

Al-Ameed Journal for Medical Research and Health Sciences

Background: Preformulation studies have a significant role in anticipating formulation problems and identifying logical paths in dosage form technology.

Aim: This study aimed to evaluate the preformulation criteria of the aquatic ethanol extract of Kigelia africana fruit as topical antibacterial therapy.

Methods: The preformulation parameters of the extract were evaluated by testing its organoleptic characteristics, melting point, pH, spectroscopic assay, stability, solubility, and partition coefficient.

Results: The study demonstrated that the extract possessed satisfactory organoleptic properties, a melting point of 195.3–198.0 °C, a pH of 6.26, chemical stability under acidic conditions, photostability, higher solubility in basic conditions and in the …

The State Of Ong Scholarship - A Symposium At Gonzaga University, Sara Van Den Berg, Thomas D. Zlatic, Paul A. Soukup, James Jarc, Kristina J. Morehouse, Heather M. Crandall, Dung Q. Tran, Kateland Wolfe

Communication Research Trends

No abstract provided.

Variability And Frequency Of Daily Rainfall In Riyadh, Saudi Arabia, Mohammed Abdullah Ai-Saleh

The Geographical Bulletin

This study examines the temporal and spatial distribution of rainfall in the city of Riyadh, Saudi Arabia's capital. The city has experienced significant urbanization in the past two decades. Therefore, the impervious surfaces and the restriction of original surface flow routes increase runoff in Riyadh city. Thus, stormwater frequently accumulates in streets because it exceeds the storm sewer capacity, storm sewers are blocked or partially blocked by sediment, or due to the lack of storm sewers. Data from three climatic stations in Riyadh and north of the city are used to characterize the temporal and spatial variations of rainfall amounts …

Public Relations And Marketing On Websites Of Guide Dog Organizations, Sakura Mizuta, Mayuko Kato-Shimizu, Naoko Koda

People and Animals: The International Journal of Research and Practice

This study investigates websites of organizations that train and provide guide dogs to visually impaired people and present marketing methods as social welfare services. The study also makes suggestions for improving the websites. Among the members of the International Guide Dog Federation, 110 official websites of the organizations were analyzed. Websites were evaluated based on criteria including organizational basics, staff details, top page images, donation information, guide dog application guidance, user comments, and specific guide dog information. The websites play various roles, such as providing both general and visually impaired people with information on organizational activities, while calling for donations. …

A Multisensory, Interdisciplinary Approach To Visual Neglect For Enhancement Of Visual Attention Following Basal Ganglia Hemorrhage: A Case Report, Leah G. Allan

The Open Journal of Occupational Therapy

Background: This case report provides a review of the medical background and inpatient rehabilitation course of a 41-year-old female presenting with right basal ganglia hematoma in the setting of hypertension and polysubstance use. Emphasis is placed on analysis and discussion of the interdisciplinary, multisensory therapy approaches used to address her visual neglect and homonymous hemianopia.

Method: Single-patient case report

Results: On the Disability Rating Scale, the patient’s score improved from a Day 16 score of 10 to a Day 58 score of 7. On the Modified Barthel Index, her performance improved from a Day 16 score of …

Psychosocial Occupational Therapy Interventions For Pediatric Traumatic Brain Injury: A Scoping Review, Sabina Khan, Christianah Edema

The Open Journal of Occupational Therapy

Background: We aimed to examine the psychosocial interventions used by occupational therapists in managing pediatric TBI, and to identify unique psychosocial needs in this population.

Methods: The scoping review was guided by Arksey and O'Malley's framework. Four databases were searched for relevant studies namely: Embase (Elsevier), Medline (PubMed), Cochrane Library, and PsycNet. Included studies were studies written in English reporting on psychosocial interventions for pediatric TBI by occupational therapists and/or the psychosocial needs of children with TBI.

Results: The search identified 13 relevant studies published from 2006 to 2020. Multiple psychosocial interventions were pinpointed in these studies, …

Mitochondrial A3 Adenosine Receptor As A Mechanism For The Protective Effects Of A3ar Agonists On Chemotherapy-Induced Neuropathic Pain, Timothy M. Doyle, Kali Janes, Wen Hua Xiao, Grant R. Kolar, Hans F. Luecke, Michael Anne Gratton, Dilip K. Tosh, Kenneth A. Jacobson, Gary J. Bennett, Daniela Salvemini

Biological Sciences Faculty Research & Creative Works

Alterations in mitochondrial function are the linchpin in numerous disease states including in the development of chemotherapy-induced neuropathic pain (CIPN), a major dose-limiting toxicity of widely used chemotherapeutic cytotoxins. In CIPN, mitochondrial dysfunction is characterized by deficits in mitochondrial bioenergetics (e.g., decreased ATP production) that are thought to drive the degeneration of the peripheral nerve sensory axon terminal sensory arbors in the skin (the intraepidermal nerve fibers; IENFs) and induce abnormal spontaneous discharge in peripheral nerve sensory axons. Preserving mitochondrial function is anticipated to prevent CIPN. We have now discovered that the G-protein-coupled receptor, A3 adenosine receptor subtype (A3AR), is …

The Next Public Health Frontier With Indoor Air Quality, Lynette B. Martins

Tulsa Law Review

No abstract provided.

The Syntax Of Natural Language, Michael Diercks, Beatrice Santorini, Anthony Kroch

Pomona Faculty Books

An introductory textbook to the syntax of natural language from the perspective of generative syntactic theory. Suitable for undergraduate courses and introductory graduate courses.

Eng 1009g-150 Stories Matter, Travis Moody

Spring 2025

No abstract provided.

A Multilayer, Multimethod Web And Language Accessibility Analysis Of U.S. Nonprofit Organization Websites: Considerations For The Marketing And Promotion Of Online Giving, Alicia Mason, Lauren Baldwin, Tatum Ahring

Faculty Submissions

In lieu of recent declines in individual giving to US nonprofits focused on social causes, education, environment, and animal welfare, this study examines the web and language accessibility of US nonprofit websites. By examining potential accessibility design barriers, we seek to understand whether US nonprofit organizations are limiting their outreach to online donors, specifically persons with disabilities (PwDs). Nonprofit websites were systematically and randomly sampled from Charity Navigator's Alphabetical Listing of the Top 1000 Most Visited Charities database. Using a multimethodological approach consisting of manual verification and computer-automated analysis techniques, we assess the web and language accessibility of leading US …

"A Rose By Any Other Name Would Smell As Sweet": Economics And Consumer (I.E., Client) Benefit From Keyword Bidding On Competitor Names Among Law Firms, Angel Reyes Iii

Tulsa Law Review

No abstract provided.

Pharmacotherapeutic Efficacy Of Astaxanthin Toward Breast Cancer: A Systematic Review, Harnd Abdullah Ali, Bushra Hassan Marouf, Lanja Ibraheim Saeed, Rafl M. Kamil, Savan Mohammed Dilshad

BioMed Visions Journal

Background: Breast cancer (BC) is one of the most common malignancies in women, characterized by the malignant proliferation of breast epithelial cells that significantly impairs patients’ quality of life. Astaxanthin (ASN), a marine-derived xanthophyll carotenoid, is known for its antioxidant and anti-inflammatory properties. Emerging evidence suggests that ASN may exert anti-neoplastic effects by inhibiting tumorigenesis and suppressing the growth and progression of BC cells. This systematic review aims to critically evaluate the therapeutic potential of ASN as a pharmacological agent in the prevention and management of breast cancer.

Methodology: Following PRISMA 2020 guidelines, a comprehensive literature search was conducted in …

Visual Mindful Autoethnography In Practice: Integrating Visual Expressive Art And Self-Compassion Into The Research Process, Jennifer Bentley

Mindfulness Studies Theses

This thesis introduces the framework of Visual Mindful Autoethnography (VmAE) which integrates mindfulness, self-compassion, and creative visual expression as tools for reflexive self-inquiry within the research process. Grounded in the principles of autoethnography and mindfulness, VmAE fosters a deep engagement with personal narratives, biases, and cultural contexts while encouraging emotional resilience, self-awareness, and ethical integrity. By utilizing techniques such as expressive art and visual process journalling, this approach re-presents the inner emotional landscape while facilitating a balanced exploration of subjective experience. The framework is supported by the “P.A.C.E. Research with C.A.R.E.” model, which establishes mindfulness and self-compassion as foundational principles …

Ifá And Mindfulness: Two Distinct Practices With Parallel Concepts To Improve Mental Health, Frank Matias

Mindfulness Studies Theses

This research compares the West African Ifá tradition with Western mindfulness in promoting mental health and well-being. Both Ifá and mindfulness aim to strengthen the mind and enhance awareness. Negative emotions like anger, grief, and confusion disturb our peace and composure, leading to reactive responses. Negative emotions can significantly affect our mental well-being. Ifá and mindfulness practices support each other by improving cognitive skills and raising awareness of challenges. I will analyze the Ifá principles of Orí (head/mind), Òríṣàs (emotional guidance), Ìwá-pèlé (good character/patience), Ese Ifá (poetic verses), and Odù Ifá (binary code/Ifá literary corpus) alongside the mindfulness practice of …

« Au Cœur Du Harem » Et Du Métissage Linguistique D’Elisa Chimenti En Italien : Comparaison Différentielle Et Décentrement Linguistique, Pierpaolo Amenta

Al-Kīmiyā

This article examines the literary language of Elisa Chimenti (1883-1969), which is full of xenisms, linguistic loans, metaphors, and idioms that stem from a transcultural and heterolingual imaginary. Her novel Au cœur du harem (Éditions du Scorpion, 1958), translated into Italian in 2000 under the supervision of Emanuela Benini (Edizioni E/O), is a striking example. Drawing on a differential comparative approach (Heidmann, 2017), we look at these texts to reflect on Elisa Chimenti’s literary language and to examine the translational stakes of her work and its heterolingualism (Grutman, 1997; Suchet, 2014).

English title
Au cœur du harem (In the Heart …

Cannabis Law Practice: Lessons For The Legal Profession In The Twenty-First Century, Eli Wald

Tulsa Law Review

No abstract provided.

Performance Assemblages | Motion Capture, La Samuelson, Movement Lab

Course Materials & Research

No abstract provided.

Wild Magic Farms: Increasing Student Engagement And Decreasing Academic Regression In Middle School Extended School Year Through Use Of A Role-Playing Game, Maryanne Cullinan

Educational Studies Dissertations

The Extended School Year (ESY) is a federal program that falls under the Individuals with Disabilities Education Act Law (2004) as part of Special Education in public schools in the United States. It is intended to help reduce regression in student progress towards Individualized Education Program goals. However, in New Hampshire, ESY struggles with a lack of clear goals, student buy-in and quality engagement. This study examined how a researcher designed role-playing game (RPG) could impact both summer academic regression and student engagement in a middle school ESY. Utilizing i-Ready testing (n=13) data and attendance data (n=9), this study compared …

Ucf Pegasus Plan - 1st Grade - Maps & Globes, Cecilia Nuss, Mackenzie Luley, Jessenia Diaz, Alyssa Arnott, Miranda Howley

Pegasus Plans: Social Studies Unit Plans for Florida Teachers

During this unit, students will explore and create various maps and globes through multimedia resources, Hands-on activities, and assessments. The daily lessons cover topics such as a compass rose, cardinal directions, map titles, and physical features on maps and globes. By the end of this unit, students will be able to identify key elements and locate physical features of maps and globes. Through the use of songs, hands-on activities, games, books, and class discussions, students will be engaged throughout the unit.

Alma Link Resolver Subject Report 2023-2024, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2023-2024 on the number of OpenURL requests by Library of Congress classification code made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries.

Information provided includes Classification Code, Classifications, Number of Requests, Number of Clicked Requests, and % Clicks from Requests.