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2025

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A Dialogue On Children’S Television, Valerio Fuenzalida, Ulrika Sjöberg, Katharine Heintz, Ellen Wartella, David Kleeman Jan 2025

A Dialogue On Children’S Television, Valerio Fuenzalida, Ulrika Sjöberg, Katharine Heintz, Ellen Wartella, David Kleeman

Communication Research Trends

No abstract provided.


Trends In Wildlife Strikes To Aircraft In Brazil: Implications For Airport Operators, Flavio A. C. Mendonca, Chenyu Huang, Julius Keller, Carolina Anderson Jan 2025

Trends In Wildlife Strikes To Aircraft In Brazil: Implications For Airport Operators, Flavio A. C. Mendonca, Chenyu Huang, Julius Keller, Carolina Anderson

Journal of Aviation Technology and Engineering

Purpose. Brazilian airport operators face persistent challenges from wildlife hazards to aircraft operations, necessitating the development and implementation or review of existing wildlife hazard management plans. Enhancing airport operators’ ability to allocate resources effectively requires a deeper understanding of past wildlife strikes. This study aimed to provide empirical insights derived from the analyses of wildlife strike and aircraft operations data in Brazil to support accident prevention endeavors.

Design/methodology. The researchers utilized two main datasets: the Brazilian National Wildlife Strike Database and the annual reports on aircraft traffic operations published by the Brazilian Department of Airspace Control. For this study, wildlife …


Read The Sign: The Equal Protection Clause Does Not Require Gender-Affirming Bathroom Access In Schools, Stephen J. Nast Jan 2025

Read The Sign: The Equal Protection Clause Does Not Require Gender-Affirming Bathroom Access In Schools, Stephen J. Nast

Liberty University Law Review

For thousands of years, bathrooms have been separated by sex—male and female. In fact, for most of human history, there has been a universal understanding that only male and female sexes existed. It was not until the twentieth century that the notion that there could be more than two sexes was popularized and the term “transgender” was introduced to society. By the mid-2010s, the idea that bathrooms should be separated by male and female began to receive opposition. As explored throughout this Comment, children identifying as transgender have filed lawsuits against school boards that did not permit children to use …


Class Iii Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 In Cardiovascular Health And Disease, Yuanjun Shen, Jason Gleghorn Jan 2025

Class Iii Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 In Cardiovascular Health And Disease, Yuanjun Shen, Jason Gleghorn

Pharmacy Faculty Scholarship

Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining cardiovascular health and the development of cardiovascular diseases (CVDs). Specifically, vacuolar Protein Sorting 34 (VPS34) or PIK3C3, the only member of Class III PI3K, plays an important role in CVD progression. The main function of VPS34 is inducing the production of phosphatidylinositol 3-phosphate, which, together with other essential structural and regulatory proteins in forming VPS34 complexes, further regulates the mammalian target of rapamycin activation, autophagy, and endocytosis. VPS34 is found to have crucial functions in the cardiovascular system, including dictating the proliferation and survival of vascular smooth muscle cells and cardiomyocytes …


Priority Competencies For Designated Education Officers In The Veterans Health Administration, Duane R. Bidwell, Anita Samuel, Ronald M. Cervero, Steven J. Durning, Sherri L. Stephan, Erin L. Patel, Marjorie A. Bowman, Holly S. Meyer Jan 2025

Priority Competencies For Designated Education Officers In The Veterans Health Administration, Duane R. Bidwell, Anita Samuel, Ronald M. Cervero, Steven J. Durning, Sherri L. Stephan, Erin L. Patel, Marjorie A. Bowman, Holly S. Meyer

Population and Public Health Sciences Faculty Publications

Designated Education Officers (DEOs) at Veteran Health Administration (VHA) hospitals are senior educational leaders tasked with oversight of all clinical training at a particular facility. They prioritize dozens of tasks and responsibilities each day, from educational policy and strategy to staff management, financial planning, onboarding of trainees, and facility planning and management. Clarifying priority competencies for the role can help executives recruit, appoint, and evaluate capable personnel and promote effective, efficient performance. Using a federally developed method of competency analysis, researchers consulted a panel of subject-matter experts to identify priority competencies for DEOs, using data from a 2013 study that …


Brief Of Criminal Law Professors Andrea Roth And J.D. King As Amici Curiae In Support Of Petitioner, Lesh V. United States, U.S. Supreme Court Docket No. 24-654, David B. Owens Jan 2025

Brief Of Criminal Law Professors Andrea Roth And J.D. King As Amici Curiae In Support Of Petitioner, Lesh V. United States, U.S. Supreme Court Docket No. 24-654, David B. Owens

Court Briefs

QUESTION PRESENTED

Article III of the Constitution provides that “[t]he Trial of all Crimes, except in Cases of Impeachment, shall be by Jury.” And the Sixth Amendment provides that “[i]n all criminal prosecutions,” the accused shall enjoy the right to trial by jury.

The question presented is: Whether the Constitution’s dual guarantee of trial by jury contains an unstated exception for “petty” offenses.


Young Adult Fiction Through The Years: An Analysis Of What Readers Want, Treanna Greenwood Jan 2025

Young Adult Fiction Through The Years: An Analysis Of What Readers Want, Treanna Greenwood

Masters Theses

In this literary critique, I discuss the advantages of reading young adult fiction, specifically fantasy. I define what young adult fantasy is, and then analyze some of the most famous young adult book series and discuss how popular they are and how they contribute to the genre. I also discuss works that are relevant to the creative piece I am submitting and explain why my piece has a place in the world of young adult fantasy. Finally, I acknowledge what I hope to contribute to the field.


Historical And Theological Evidence Of Jesus' Resurrection In Paul's Undisputed Letters, Steven Cung Za Kham Jan 2025

Historical And Theological Evidence Of Jesus' Resurrection In Paul's Undisputed Letters, Steven Cung Za Kham

Masters Theses

This thesis investigates the historical authenticity and theological significance of Jesus’ resurrection as presented in the letters of Paul. The resurrection, central to the Christian faith, has sparked considerable scholarly interest as a foundational event offering humanity its greatest hope. Among early witnesses, the Apostle Paul stands out due to his transformative encounter with the risen Christ, which radically altered his life from a persecutor of Christians to an ardent advocate of the resurrection. His letters, written within a few decades of Jesus' death, provide key insights into what Paul and early Christians truly believe about the resurrection. The study …


Uncovering Faith In The Desert: A Hired Gun’S Redemption, Scott K. Shea Jan 2025

Uncovering Faith In The Desert: A Hired Gun’S Redemption, Scott K. Shea

Masters Theses

This paper examines the perception of God during arduous times and throughout an individual's life, with a particular focus on wartime experiences. War is the backdrop for numerous personal narratives, with the themes of redemption and the search for faith central to this discussion. It raises the question, "Is it possible to find God amidst the chaos of war?" Throughout history, many military personnel have shared profound experiences of fate, often turning to God in desperate pleas for survival. It is essential to examine the concept of war in a broader context, considering its connection to biblical teachings and understanding, …


The Problem With Evangelism And A Move Towards Discipleship In Thailand, Micheal J. Hurley Jan 2025

The Problem With Evangelism And A Move Towards Discipleship In Thailand, Micheal J. Hurley

Masters Theses

This paper will propose a new way for short term missions to work in Thailand. The nation of Thailand allowed freedom of religion for almost a century and a half, yet the Christian population struggles to exist. As one of the smallest religious groups, Christian missionaries have struggled to make inroads within this country. Thais do what is best for the community over themselves. They want to receive benefit today for their efforts. With little to no hope found for the next better life sought after in Buddhism, one would think Christianity would provide this hope. However, it is out …


Federal Communications Commission V. Consumers' Research: Brief Of Julian Davis Mortenson And Nicholas Bagley As Amici Curiae In Support Of Petitioners, Julian Mortenson, Nicholas Bagley Jan 2025

Federal Communications Commission V. Consumers' Research: Brief Of Julian Davis Mortenson And Nicholas Bagley As Amici Curiae In Support Of Petitioners, Julian Mortenson, Nicholas Bagley

Appellate Briefs

Julian Davis Mortenson and Nicholas Bagley are professors at the University of Michigan Law School. Mortenson is a specialist on the history of executive authority and the separation of powers. Bagley is a leading scholar in administrative law. They are the co-authors of Delegation at the Founding, 121 Colum. L. Rev. 277 (2021), a leading article examining Founding- era constitutional principles regarding legislative delegations of authority, and Delegation at the Founding: A Response to the Critics, 122 Colum. L. Rev. 2323 (2022).


Spectator 2025-01-16, Editors Of The Spectator Jan 2025

Spectator 2025-01-16, Editors Of The Spectator

The Spectator

No abstract provided.


Usa V. Dwayne Sherman Jan 2025

Usa V. Dwayne Sherman

2025 Decisions

USDC for the Middle District of Pennsylvania


Adryan Scicluna, Adryan John Scicluna Mr Jan 2025

Adryan Scicluna, Adryan John Scicluna Mr

Staff Scholarship - Australia & Dubai

This work was developed specifically for the forthcoming VDP220 course in the School of VFX, as a marketing source. This output of work and others like it serves as evidence of the level of digital sculpting capability our students can achieve when technical skills are integrated with conceptual thinking, to creatively engaging process to embark on an iterative journey. Character development of this nature demonstrates how personal vision, world building, and narrative intent can meaningfully inform technical outcomes. It prompts consideration of the types of worlds and characters our students are capable of creating when encouraged to move beyond functional …


The Role Of Learned Helplessness On Academic Baseline Levels In Adult Education Students Enrolling In A High School Equivalency Program, Kippie Barnwell Hartcraft Jan 2025

The Role Of Learned Helplessness On Academic Baseline Levels In Adult Education Students Enrolling In A High School Equivalency Program, Kippie Barnwell Hartcraft

Student Theses and Dissertations

The purpose of this non-experimental quantitative study was to investigate the relationship between learned helplessness and academic baseline levels among adult students who dropped out of high school and have returned to a high school equivalency program to prepare to take the GED examination. The study controlled for the variables of the age of the student at the time of GED program enrollment, gender, race/ethnicity, and socioeconomic status. It is not known if, and to what degree, learned helplessness impacts academic baseline levels in reading, mathematics, and language in adult students. Learned helplessness, a maladaptive condition as demonstrated by low …


Halogeton And Greasewood Poisoning In Cattle And Sheep In Utah, E. Jane Kelly, Stephen T. Lee, Ammon Brown, Daniel Cook Jan 2025

Halogeton And Greasewood Poisoning In Cattle And Sheep In Utah, E. Jane Kelly, Stephen T. Lee, Ammon Brown, Daniel Cook

Poisonous Plant Research (PPR)

Halogeton (Halogeton glomeratus) is a fast-growing annual plant while greasewood (Sarcobatus vermiculatus) is a perennial shrub of the Western States. Oxalates are the toxic principle in halogeton and greasewood. Most losses occur when hungry animals are allowed to graze in heavy stands of halogeton and greasewood. Halogeton and greasewood are always dangerous and become more toxic as the growing season progresses. Here we report on two clinical cases of halogeton and greasewood poisoning in cattle and sheep. Histologically, oxalate crystals were observed in the kidneys of the cow and sheep consistent with oxalate poisoning. Oxalate was …


Refurbishing Used Gps Transmitters Improves Performance For Subsequent Deployments On Greater Sage-Grouse, Melissa S. Chelak, Michel T. Kohl, Justin R. Small, Kurt T. Smith, Aaron C. Pratt, Jeffrey L. Beck, Codi R. Backen, M. Brandon Flack, Hailey P. Wayment, Jason A. Wood, Ryan Howell, Trevon D. Strange, Lucian R. Mcdonald, Kezia R. Manlove, Shandra N. Frey, Randy T. Larsen, Brian A. Maxfield, David K. Dahlgren, Terry A. Messmer, David C. Stoner Jan 2025

Refurbishing Used Gps Transmitters Improves Performance For Subsequent Deployments On Greater Sage-Grouse, Melissa S. Chelak, Michel T. Kohl, Justin R. Small, Kurt T. Smith, Aaron C. Pratt, Jeffrey L. Beck, Codi R. Backen, M. Brandon Flack, Hailey P. Wayment, Jason A. Wood, Ryan Howell, Trevon D. Strange, Lucian R. Mcdonald, Kezia R. Manlove, Shandra N. Frey, Randy T. Larsen, Brian A. Maxfield, David K. Dahlgren, Terry A. Messmer, David C. Stoner

Wildland Resources Student Research

Global Positioning Systems (GPS) radio transmitters are increasingly used across taxa to monitor animal populations. However, GPS transmitters can be susceptible to malfunctions that may result in location errors or data loss causing potential inferential bias that can have important implications for monitored species. Research using GPS transmitters on greater sage-grouse (Centrocercus urophasianus; sage-grouse) has increased, but few sage-grouse studies have evaluated GPS performance. Because sage-grouse management has been subject to intense legal and political scrutiny with consequential economic implications, reliable data acquisition is central to informed decision-making for the species. We evaluated differences in the performance of …


Was Spinoza A Deleuzian? Rethinking The Politics Of Emotions And Affects, Ahmet Aktas Jan 2025

Was Spinoza A Deleuzian? Rethinking The Politics Of Emotions And Affects, Ahmet Aktas

Department of Philosophy Student Publications

A salient tradition in contemporary affect theory heavily relies on distinguishing between emotions and affects. The former refers to structured categories of socially coded affective states, while the latter denotes the pre-social libidinal flow underlying emotions. This distinction is commonly attributed to Spinoza and is thought to have been further developed by Deleuze. In this article, I argue that this overall historical picture is misleading and inaccurate. Deleuze radically transforms Spinoza’s theory of affect for the ends of his own ethical-political philosophy. Moreover, I argue that Deleuzian and similar conceptualizations of affect fail to fulfill their political and ethical promises …


The Positive Effects Of Audience Participation In Classic Literature, Joyelle Davis Braggs Jan 2025

The Positive Effects Of Audience Participation In Classic Literature, Joyelle Davis Braggs

Masters Theses

My thesis reviews the history of fan-fiction and how it plays a role in the world of literature, specifically classic literature. It focuses on Jane Eyre and Charlotte Bronte as well as the reasons why that storyline concluded the way it did. Also, I review the reasons why fans have decided to write their own versions of stories to either refresh or renew a character or storyline.

There is a brief history of fan-fiction and a simple summary of Jane Eyre. Included are examples of fan fiction that faced legal challenges both successfully and unsuccessfully. I have also shared my …


Witchcraft, Demons, And Spiritual Death: An Apologetic For The Bible's Prohibition Against Witchcraft, Joshua Dean Wrenn Jan 2025

Witchcraft, Demons, And Spiritual Death: An Apologetic For The Bible's Prohibition Against Witchcraft, Joshua Dean Wrenn

Masters Theses

This paper attempts to apologetically defend the Bible's intolerance against witchcraft and other related activities that are prohibited in the Old Testament. It does so by showing that Witchcraft and other related activities gets one involved with demonic entities. It shows how demonic entities are deceitful, and how they are actually the ones behind the power of witchcraft. The paper starts by studying the history of ancient witchcraft, which is something that is useful for understanding the witchcraft of today. It then builds a profile of demons. The paper shows what demons physically do and what they attempt to get …


The Pragmatic Effect Of Φιλέω And Αγαπάω In John 21:15-17, Steven J. P'Pool Jan 2025

The Pragmatic Effect Of Φιλέω And Αγαπάω In John 21:15-17, Steven J. P'Pool

Masters Theses

The final chapter of John’s gospel is central to the New Testament in that it depicts the risen Jesus appearing to His disciples and sharing a meal with them, restoring Peter to his place as a leader among his brothers, and records John’s eyewitness testimony to the events reported. It is in verses fifteen through seventeen of chapter twenty-one that attention turns to Peter and John, with the latter eaves dropping on the conversation. John records the conversation in these three verses in which Jesus restores Peter from his trio of denials prior to Jesus’ crucifixion with three opportunities for …


Rsk1 Is An Exploitable Dependency In Myeloproliferative Neoplasms And Secondary Acute Myeloid Leukemia, Tim Kong, Angelo B A Laranjeira, Christopher T Letson, Layow Yu, Shuyang Lin, Jared S Fowles, Daniel A C Fisher, Sherwin Ng, Wei Yang, Fan He, Jingxian Liu, Alexander B Kim, Maggie J Cox, Mary C Fulbright, Stacey L Rentschler, Li Ding, Grant A Challen, Stephen T Oh, Et Al. Jan 2025

Rsk1 Is An Exploitable Dependency In Myeloproliferative Neoplasms And Secondary Acute Myeloid Leukemia, Tim Kong, Angelo B A Laranjeira, Christopher T Letson, Layow Yu, Shuyang Lin, Jared S Fowles, Daniel A C Fisher, Sherwin Ng, Wei Yang, Fan He, Jingxian Liu, Alexander B Kim, Maggie J Cox, Mary C Fulbright, Stacey L Rentschler, Li Ding, Grant A Challen, Stephen T Oh, Et Al.

2020-Current year OA Pubs

Myeloid malignancies are heterogenous disorders characterized by distinct molecular drivers but share convergence of oncogenic signaling pathways and propagation by ripe pro-inflammatory niches. Here, we establish a comprehensive transcriptional atlas across the spectrum of myeloproliferative neoplasms (MPN) and secondary acute myeloid leukemia (sAML) through RNA-sequencing of 158 primary samples encompassing CD34+ hematopoietic stem/progenitor cells and CD14+ monocytes. Supported by mass cytometry (CyTOF) profiling, we reveal aberrant networks of PI3K/AKT/mTOR signalling and NFκB-mediated hyper-inflammation. Combining ATAC-Seq, CUT&Tag, RNA-seq, and CyTOF, we demonstrate that targeting of ribosomal protein S6 kinase A1 (RSK1) suppresses NFκB activation and diminishes pro-inflammatory mediators including tumor necrosis …


Exploring The Pathogen Profiles Of Ancient Feces, Drew Capone, David Holcomb, Amanda Lai, Karl Reinhard, Joe Brown Jan 2025

Exploring The Pathogen Profiles Of Ancient Feces, Drew Capone, David Holcomb, Amanda Lai, Karl Reinhard, Joe Brown

Karl Reinhard Publications

Analysis of ancient desiccated feces – termed paleofeces or coprolites – can unlock insights into the lives of ancient people. We collected desiccated feces from caves in the Rio Zape Valley in Mexico (725-920 CE). First, we extracted DNA with methods previously optimized for paleofeces. Then, we applied highly sensitive modern molecular tools (i.e., PCR pre-amplification followed by multi-parallel qPCR) to assess the presence of 30 enteric pathogens. We detected ≥1 pathogen associated gene in each of the ten samples and a mean of 3.9 pathogens per sample. The targets detected included Blastocystis spp. (n=7), atypical enteropathogenic E. coli (n=7), …


Calcium Phosphate Formation And Deposition In Ischemic Neurons, Shu Q. Liu, John B. Troy, Jeremy Goldman, Roger J. Guillory Jan 2025

Calcium Phosphate Formation And Deposition In Ischemic Neurons, Shu Q. Liu, John B. Troy, Jeremy Goldman, Roger J. Guillory

Michigan Tech Publications

Ischemic stroke causes acute brain calcium phosphate (CaP) deposition, a process involving primarily the injured neurons. Whereas the adverse impact of CaP deposition on the brain structure and function has been recognized, the underlying mechanisms remain poorly understood. This investigation demonstrated that the neuron-expressed, plasma membrane-associated Ca2+-binding proteins annexin (Anx) A2, AnxA5, AnxA6, and AnxA7 contributed to neuronal CaP deposition in the mouse model of ischemic stroke. These Anxs were released from the degraded plasma membrane of the ischemic neurons and were able to form Anx/CaP complexes, a nanostructure capable of binding to the β actin filaments via Anx–actin interaction …


The Influence Of The Un Watercourses Convention On The Development Of A Policy Design In The Nile River Basin, Zienab Ali Abdelhady Jan 2025

The Influence Of The Un Watercourses Convention On The Development Of A Policy Design In The Nile River Basin, Zienab Ali Abdelhady

Theses and Dissertations

The adoption in 1997 of the United Nations Convention on the Law of the Non-navigational Uses of International Watercourses (UN Watercourses Convention or UNWC) marked a milestone in the codification and progressive development of international water law. Similarly, the signature in 2010 by the majority of the Nile Basin states of the Nile River Basin Cooperative Framework Agreement (CFA) was a major step towards a permanent legal and institutional framework as well as a significant shift from the currently applicable legal regime in the basin. The research concludes that the principles enshrined in the UNWC can assist future regional treaty …


Using Implementation Mapping To Design An Implementation Strategy For Classroom-Based Physical Activity Approaches In Elementary Schools, Timothy J Walker, Derek W Craig, Christopher D Pfledderer, Kempson Onadeko, Emma E Saving, Hildi M Nicksic, Krista Patlovich, Keisey Fumero, John B Bartholomew, Maria E Fernández Jan 2025

Using Implementation Mapping To Design An Implementation Strategy For Classroom-Based Physical Activity Approaches In Elementary Schools, Timothy J Walker, Derek W Craig, Christopher D Pfledderer, Kempson Onadeko, Emma E Saving, Hildi M Nicksic, Krista Patlovich, Keisey Fumero, John B Bartholomew, Maria E Fernández

Faculty, Staff and Student Publications

Background: Physically active breaks and lessons are evidence-based approaches to improving student's physical activity. Yet, schools and teachers face implementation challenges, requiring the need for effective implementation strategies.

Purpose: Use Implementation Mapping to develop an implementation strategy for physically active breaks and lessons in elementary schools.

Methods: With our partner school district, we assembled a planning group with expertise in education, public health, and implementation science. The group completed five Implementation Mapping tasks: (i) conduct needs and assets assessment and identify adopters and implementers, (ii) identify implementation outcomes, performance objectives, and determinants, and create matrices of change objectives, (iii) choose …


Improving Cooking Skills, Lifestyle Behaviors, And Clinical Outcomes For Adults At Risk For Cardiometabolic Disease: Protocol For A Randomized Teaching Kitchen Multisite Trial (Tk-Mt), Jennifer Massa, Candace Sapp, Kate Janisch, Mopelola A Adeyemo, Auden Mcclure, Natalia I Heredia, Deanna M Hoelscher, Tannaz Moin, Shaista Malik, Wendelin Slusser, David M Eisenberg Jan 2025

Improving Cooking Skills, Lifestyle Behaviors, And Clinical Outcomes For Adults At Risk For Cardiometabolic Disease: Protocol For A Randomized Teaching Kitchen Multisite Trial (Tk-Mt), Jennifer Massa, Candace Sapp, Kate Janisch, Mopelola A Adeyemo, Auden Mcclure, Natalia I Heredia, Deanna M Hoelscher, Tannaz Moin, Shaista Malik, Wendelin Slusser, David M Eisenberg

Faculty, Staff and Student Publications

BACKGROUND/OBJECTIVES: This protocol describes a study to investigate the feasibility and preliminary efficacy of a novel Teaching Kitchen Multisite Trial (TK-MT) for adults with cardiometabolic abnormalities. The TK-MT protocol describes a hybrid lifestyle intervention combining in-person and virtual instruction in culinary skills, nutrition education, movement, and mindfulness with community support and behavior change strategies. This 18-month-long randomized controlled trial aims to evaluate the feasibility of implementing a 12-month, 24 class program, assess preliminary study efficacy, and identify barriers and facilitators to implementation.

METHODS: The intervention program includes 16 weeks of intensive hands-on culinary and lifestyle education classes followed by eight …


Understanding The Impact Of Covid-19 On The Mental Health Of Children And Parents During The Pandemic, Whitney S. Gray Jan 2025

Understanding The Impact Of Covid-19 On The Mental Health Of Children And Parents During The Pandemic, Whitney S. Gray

Doctoral Dissertations and Projects

The COVID-19 pandemic presented parents with stressors that affected their well-being and their life satisfaction. The pandemic caused parents to struggle with balancing their families’ needs and maintaining their happiness. Prior to the pandemic, children and adolescents had a routine that accommodated their daily functioning and provided them with social contact. The pandemic added stress with parents working odd hours at work, having to adjust to their child’s school schedules, and not being able to contribute to their support system. In addition to these daily stressors, parents had to consider the precautions surrounding COVID-19 and the worries attached to the …


Exploring Joint Manifestations In Rasopathies: A Prospective Survey, Lavinia Dobrea Jan 2025

Exploring Joint Manifestations In Rasopathies: A Prospective Survey, Lavinia Dobrea

Doctoral Dissertations and Projects

RASopathies, a group of genetic diseases, affects approximately 1 in 1000 people worldwide. Despite advances documented in medical journals, there is limited understanding about the impact of various joint problems on activities of daily living (ADL) and quality of life (QOL) among those afflicted. This study was conducted, utilizing a qualitative phenomenological methodology, to better understand the lived experiences of people with RASopathies impacted by joint problems. Participants were selected from RASopathy communities by employing purposeful sampling to ensure population representation. Data was obtained through online surveys and virtual interviews. Thematic analysis was used to identify recurring themes, and data …


Investigating The Role Of Endothelin-1 In Reactive Astrocytosis, Candace Betancourt-Szymanowska Jan 2025

Investigating The Role Of Endothelin-1 In Reactive Astrocytosis, Candace Betancourt-Szymanowska

Master's Theses

Glaucoma is a progressive optic neuropathy which results in blindness for many patients, even with treatment. Endothelin-1 (ET-1) is a vasoactive peptide known to be aberrantly upregulated in the eyes of individuals with glaucoma. Optic nerve head astrocytes (ONHA) are the resident glial cell of the optic nerve head and are among the first cell types to undergo changes to a reactive phenotype. In this thesis, we investigated the role of ET-1 overexpression and its putative role in eliciting a reactive phenotype in ONHA by inducing lentiviral-mediated over-expression of EDN1. ONHA transduced with EDN1 (ONHA ET-1) were verified to be …