Digital Commons Network^™

Notch3 Deletion Regulates Hiv-1 Gene Expression And Systemic Inflammation To Ameliorate Chronic Kidney Disease, Mackenzie Thornton, Nicole Sommer, Mercedes Mcgonigle, Anil Kumar Ram, Sireesha Yerrathota, Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan, Anubhav Chakraborty, V. Praveen Chakravarthi, Sumedha Gunewardena, Mudit Tyagi, Jaya Talreja, Tao Wang, Pravin Singhal, Pamela V. Tran, Timothy A. Fields, Patricio E. Ray, Navneet K. Dhillon, Madhulika Sharma

Center for Translational Medicine Faculty Papers

Anti-retroviral therapy (ART) has decreased human immunodeficiency virus (HIV)-1-associated morbidity. However, despite ART, immune cells remain latently infected, leading to chronic inflammation and HIV-1-associated comorbidities. New strategies are needed to target viral proteins and inflammation. We found activation of Notch3 in renal cells of the HIV-1 transgenic mouse model (HIV-Tg26) and in patients with HIV-associated nephropathy. We hypothesized that targeting NOTCH3 activation constitutes an effective therapy for HIV-related chronic kidney disease. We generated HIV-Tg26 mice with Notch3 knocked out (Tg-N3KO). Compared to HIV-Tg26 mice at 3 months, Tg-N3KO mice showed a marked reduction in renal injury, skin lesions and mortality …

Leads Data Insights: Service — February 2025, University Of North Dakota

LEADS Development Documents

February 2025 Data Insights presentation for the SERVICE core value of UND LEADS. The slides summarize Service-related Activity Inventory items and include data on innovation and economic prosperity, campus events for the general public, demographic trends for employees and students, and retention and advancement trends for faculty and staff.

Sustainable Solutions To The Continuous Threat Of Antimicrobial Resistance, Brad Spellberg, David N Gilbert, Michael Baym, Gonzalo Bearman, Tom Boyles, Arturo Casadevall, Graeme N Forrest, Sarah Freling, Bassam Ghanem, Fergus Hamilton, Brian Luna, Jessica Moore, Daniel M Musher, Travis B Nielsen, Priya Nori, Matthew C Phillips, Liise-Anne Pirofski, Andrew F Shorr, Steven Y C Tong, Todd C Lee, Emily G Mcdonald

Faculty, Staff and Students Publications

To combat antimicrobial resistance (AMR), advocates have called for passage of the Pioneering Antimicrobial Subscriptions To End Upsurging Resistance (PASTEUR) Act in the United States, which would appropriate $6 billion in new taxpayer-funded subsidies for antibiotic development. However, the number of antibiotics in clinical development, and US Food and Drug Administration approvals of new antibiotics, have already markedly increased in the last 15 years. Thus, instead of focusing on more economic subsidies, we recommend reducing selective pressure driving AMR by (1) establishing pay-for-performance mechanisms that disincentivize overprescribing of antibiotics, (2) focusing existing research and development funding on strategies that decrease …

Qm107, A Novel Cd148 (Rtp Type J) Activating Peptide Therapy For Treating Neovascular Age-Related Macular Degeneration, Samantha Arokiasamy, Michaela J M Balderstone, Faheem Shaik, Enrico Cristante, Thomas C Moseley, Akshay Madoo, Matteo Rizzi, James W Bainbridge, Konstantin Tsoyi, Ivan O Rosas, James R Whiteford, Giulia De Rossi

Faculty, Staff and Students Publications

Background and purpose: Angiogenesis is a pathological component of neovascular age-related macular degeneration. Current therapies, although successful, are prone to high levels of patient non-response and a loss of efficacy over time, indicating the need to explore other therapeutic avenues. We have shown that an interaction between syndecan-2 and the tyrosine phosphatase receptor CD148 (RTP Type J) results in the ablation of angiogenesis. Here we exploit this pathway to develop a peptide activator of CD148 as a therapy for neovascular age-related macular degeneration.

Experimental approach: We tested a peptide (QM107) derived from syndecan-2 in a variety of angiogenesis models and …

Wonoep Appraisal: Targeted Therapy Development For Early Onset Epilepsies, Pablo M Casillas-Espinosa, Jennifer C Wong, Wanda Grabon, Ana Gonzalez-Ramos, Massimo Mantegazza, Nihan Carcak Yilmaz, Manisha Patel, Kevin Staley, Raman Sankar, Terence J O'Brien, Özlem Akman, Ganna Balagura, Adam L Numis, Jeffrey L Noebels, Stéphanie Baulac, Stéphane Auvin, David C Henshall, Aristea S Galanopoulou

Faculty, Staff and Students Publications

The early onset epilepsies encompass a heterogeneous group of disorders, some of which result in drug-resistant seizures, developmental delay, psychiatric comorbidities, and sudden death. Advancement in the widespread use of targeted gene panels as well as genome and exome sequencing has facilitated the identification of different causative genes in a subset of these patients. The ability to recognize the genetic basis of early onset epilepsies continues to improve, with de novo coding variants accounting for most of the genetic etiologies identified. Although current disease-specific and disease-modifying therapies remain limited, novel precision medicine approaches, such as small molecules, cell therapy, and …

Judgment In The Presence Of Multiple Conflicting Anchors, Michael T. Bixter, Christian C. Luhmann

Department of Psychology Faculty Scholarship and Creative Works

In uncertain environments, individuals often use external cues to guide their judgments and decisions. Anchoring refers to the finding that numerical judgments often gravitate towards previously considered standards. Although an extremely robust effect, prior research on anchoring largely focused on single-anchor paradigms. The present study instead investigated how multiple anchors affect numerical judgments. In Experiment 1, participants exposed to both a low and high anchor provided judgments that were between judgments made by participants exposed solely to low or high anchors. However, anchors that were encountered first exerted a disproportionate influence on subsequent judgments. Experiment 2 replicated this primacy effect …

The Mitochondria As An Emerging Target Of Self- Renewal In T-Cell Acute Lymphoblastic Leukemia, Majd Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

Markey Cancer Center Faculty Publications

Acute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T- ALL) accounting for 15% of those cases. Despite advancements in the treatment of T-ALL, patients still face a dismal prognosis following their first relapse. Relapse can be attributed to the inability of chemotherapy agents to eradicate leukemia stem cells (LSC), which possess self-renewal capabilities and are responsible for the long-term maintenance of the disease. Mitochondria have been recognized as a therapeutic vulnerability for cancer stem cells, including LSCs. Mitocans have shown promise in T-ALL both in vitro and in vivo, with some currently in …

Potential Mental Disorder Symptoms In The Prophet Elijah: An Exegetical And Psychological Analysis Of Selected Episodes From 1 Kings 18–19, Dariusz Iwański, Thomas G. Plante

Psychology

This interdisciplinary study examines the prophet Elijah’s experiences as depicted in 1 Kings 18–19 through a multidisciplinary lens, combining theological, literary, and psychological perspectives. Drawing on literary and historical–critical methods, a biblical scholar analyzes the narrative’s linguistic and cultural dimensions, while a psychologist evaluates these findings using contemporary mental health frameworks, including the DSM-5 and models of spiritual struggle. By synthesizing these approaches, the study explores Elijah’s emotional challenges, highlighting their resonance with modern understandings of mental health and spirituality. The findings suggest that Elijah’s profound struggles—marked by triumph, despair, and renewal—offer valuable insights into the interplay of faith, vulnerability, …

Biob 171n.00: Principles Of Biological Diversity Lab, Scott R. Miller

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biob 435.01: Comparative Animal Physiology, Aaron J. Held

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biom 403.01: Pathogenic Microbes Laboratory, Amanda L. Andreas

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biom 435.01: Virology, Brent J. Ryckman

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biom 502.01: Advanced Immunology, Scott A. Wetzel

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biob 101n.01: Discover Biology, Jennifer A. Corbin

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biob 109n.50: Montana Ecosystems - Online, Gregory D. Peters

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Arth 371.50: Manga And Anime: History, Practice And Form, Alessia Carpoca

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Danc 115a.01: Introduction To Jazz Dance, Tara V. Mcfarland

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Ahrc 250.01: Respiratory Care Laboratory Ii, Paul J. Crockford

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Advanced T2nn-Taxonomy Framework For Assessing Quality Of Dynamic Logos In Digital Media Via Type-2 Neutrosophic Multi-Criteria Decision Analysis, Yan Lu, Meidi Zhang

Neutrosophic Sets and Systems

In the context of digital media, the quality evaluation of dynamic logo design focuses on visual impact, brand communication, technical execution, and user experience. Visual impact assesses the logo's appeal and creativity; brand communication examines if the logo accurately reflects the brand image; technical execution looks at animation smoothness and cross-platform compatibility; user experience measures interactivity and memorability. These factors ensure the logo's effectiveness and influence in a digital environment. The evaluation of dynamic logo design quality within the digital media context is Multi-Criteria Decision Analysis (MCDA). Recently, the Taxonomy technique was described to grapple with MCDA. The Type-2 neutrosophic …

Phl 110e.02: Introduction To Ethics, Jeffrey E. Stephenson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Phl 110e.50: Introduction To Ethics, Armond J. Duwell

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Russ 202.01: Intermediate Russian Ii, Clint B. Walker

University of Montana Course Syllabi, 2021-2025

No abstract provided.

National Ffa Parliamentary Procedure And Conduct Of Chapter Meetings Leadership Development Events Presentation Generator, P. Troy White

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

A Microsoft Excel macro-enabled workbook that produces presentation cards for the National FFA Organization's Parliamentary Procedure and Conduct of Chapter Meetings Leadership Development Events.

Each set of cards also creates a judges help sheet for the motions with proper verbiage and the Standard Descriptive Characteristics as listed in Robert's Rules of Order Newly Revised (12th edition).

The workbook uses randomization to create set cards from a list of over 300 possible main motions from a variety of internet sources. The 2024 list of eligible motions for both events was used for the permissible motions.

Religion: Evolutionary Foundation For, Nicole Fellice Ko, Norman P. Li

Research Collection School of Social Sciences

Religion refers to a structured set of spiritual beliefs and rituals. Evolution refers to the process by which living organisms transform and develop over time. Religion—the belief in spiritual beings—influences nearly every aspect of life, making it challenging to understand many phenomena without considering its influence (Bloom, 2012). About two-thirds of the world’s population is religious (Kramer & Tong, 2024); 70% of Americans consider themselves spiritual, and 83% believe they have a spirit separate from their bodies (PEW Research Center, 2023). Throughout history, religion has played a significant role in conflicts like war and continues to influence contemporary issues such …

Proactive Conversational Ai: A Comprehensive Survey Of Advancements And Opportunities, Yang Deng, Lizi Liao, Wenqiang Lei, Grace Hui Yang, Wai Lam, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

Dialogue systems are designed to offer human users social support or functional services through natural language interactions. Traditional conversation research has put significant emphasis on a system's response-ability, including its capacity to understand dialogue context and generate appropriate responses. However, the key element of proactive behavior-a crucial aspect of intelligent conversations-is often overlooked in these studies. Proactivity empowers conversational agents to lead conversations towards achieving pre-defined targets or fulfilling specific goals on the system side. Proactive dialogue systems are equipped with advanced techniques to handle complex tasks, requiring strategic and motivational interactions, thus representing a significant step towards artificial general …

El Leñador, February 2025, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

Bioh 447.01: Genes And Development Lab, Ekaterina Voronina

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biob 375.01: General Genetics, Sarah J. Certel

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Russ 494.01: Seminar In Russian Studies: Literature And The Environment, Ona Renner-Fahey

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Phl 112e.01: Ethics And The Environment, Charles B. Hayes

University of Montana Course Syllabi, 2021-2025

No abstract provided.