Digital Commons Network^™

Mouse Adrenal Macrophages Are Associated With Pre- And Postsynaptic Neuronal Elements And Respond To Multiple Neuromodulators, Matthew D. Whim

School of Medicine Faculty Publications

The adrenal medulla is packed with chromaffin cells, modified postganglionic sympathetic neurons that secrete the catecholamines, epinephrine and norepinephrine, during the fight-or-flight response. Sometimes overlooked is a population of immune cells that also resides within the gland but whose distribution and function are not clear. Here I examine the location of CD45+ hematopoietic cells in the mouse adrenal medulla and show the majority are F4/80+/Lyz2+ macrophages. These cells are present from early postnatal development and widely distributed. Anatomically they are associated with chromaffin cells, found aligned alongside synapsin-IR neuronal varicosities and juxtaposed to CD31-IR blood vessels. Using Lyz2cre-GCaMP6f mice to …

Fair Notice Is A Sociopolitical Choice, Alexander Zhang

Duke Law Journal

This Article reframes a deadlocked debate about “fair notice” as a justification for statutory interpretation methods by developing a historical account of a crucial, overlooked dimension: legislatures’ and laypeople’s value judgments about notice. On one side of the debate are idealists who contend, on due process grounds, that judges should embrace interpretive methods and theories based on how well they promote fair notice. On the other side are realists who counter, on empirical grounds, that perfect notice is impossible. Each side continues to talk past the other because we lack a fleshed-out framework for evaluating when the fair-notice basis of …

From Bench To Bedside: Murine Models Of Inherited And Sporadic Brain Arteriovenous Malformations, Ashely R Ricciardelli, Gael Genet, Nafiisha Genet, Samuel T Mcclugage, Peter T Kan, Karen K Hirschi, Jason E Fish, Joshua D Wythe

Faculty, Staff and Students Publications

Brain arteriovenous malformations are abnormal vascular structures in which an artery shunts high pressure blood directly to a vein without an intervening capillary bed. These lesions become highly remodeled over time and are prone to rupture. Historically, brain arteriovenous malformations have been challenging to treat, using primarily surgical approaches. Over the past few decades, the genetic causes of these malformations have been uncovered. These can be divided into (1) familial forms, such as loss of function mutations in TGF-β (BMP9/10) components in hereditary hemorrhagic telangiectasia, or (2) sporadic forms, resulting from somatic gain of function mutations in genes involved in …

Seguir Adelante: A Qualitative Exploration Of Latino Farmworkers' Work And Nonwork Resources., Faviola Robles Saenz, Julissa Castellanos Regalado, Larry Martinez, Greg Townley

Psychology Faculty Publications and Presentations

Latino immigrant workers have been an exploited community within many dangerous workforces, but especially within the agricultural industry. They are a crucial population for the labor and economy of the U.S., yet Latino farmworkers report feeling expendable, discriminated against, and exposed to hazardous working conditions. Due to these experiences, it is essential to explore the resources that farmworkers find valuable in improving their working conditions. This study draws upon qualitative interviews conducted with 41 Latino farmworkers in Oregon. Themes pertaining to work and nonwork resources were uncovered through thematic analysis, illustrating that farmworkers receive support from their proximal communities and …

Sewing With Fur, Cory Farnsworth

All Current Publications

Today, trapping is one of the most regulated activities worldwide and is a useful tool in managing excess populations of furbearers and struggling populations of prey animals. Fur is slowly regaining popularity as people recognize it as more ethical, humane, economical, and renewable, but the ability to use fur is becoming a lost art. It is part of our heritage as a people and connects us with the land. Learning to sew fur projects can be fun and, in some cases, quite profitable, as fur sewn into an article will sell far above the price of the pelt itself. If …

Combined Clinical, Structural And Cellular Studies Discriminate Pathogenic And Benign Trpv4 Variants, Sarah H Berth, Linh Vo, Do Hoon Kwon, Tiffany Grider, Yasmine S Damayanti, Gage Kosmanopoulos, Andrew Fox, Alexander R Lau, Patrice Carr, Jack K Donohue, Maya Hoke, Simone Thomas, Chafic Karam, Alex J Fay, Ethan Meltzer, Thomas O Crawford, Rachelle Gaudet, Michael E Shy, Ute A Hellmich, Seok-Yong Lee, Charlotte J Sumner, Brett A Mccray

Faculty, Staff and Students Publications

Dominant mutations in the calcium-permeable ion channel TRPV4 (transient receptor potential vanilloid 4) cause diverse and largely distinct channelopathies, including inherited forms of neuromuscular disease, skeletal dysplasias and arthropathy. Pathogenic TRPV4 mutations cause gain of ion channel function and toxicity that can be rescued by small molecule TRPV4 antagonists in cellular and animal models, suggesting that TRPV4 antagonism could be therapeutic for patients. Numerous variants in TRPV4 have been detected with targeted and whole exome/genome sequencing, but for the vast majority, their pathogenicity remains unclear. Here, we used a combination of clinical information and experimental structure-function analyses to evaluate 30 …

A Comprehensive Head-To-Head Comparison Of Key Plasma Phosphorylated Tau 217 Biomarker Tests, Noëlle Warmenhoven, Nicolas R Barthélemy, Suzanne E Schindler, Andrew J Aschenbrenner, Cyrus A Raji, Tammie L S Benzinger, John C Morris, Laura Ibanez, Jigyasha Timsina, Carlos Cruchaga, Randall J Bateman, Et Al.

2020-Current year OA Pubs

Plasma phosphorylated-tau 217 (p-tau217) is currently the most promising biomarker for reliable detection of Alzheimer's disease pathology. Various p-tau217 assays have been developed, but their relative performance is unclear. We compared key plasma p-tau217 tests using cross-sectional and longitudinal measures of amyloid-β (Aβ)-PET, tau-PET and cognition as outcomes and benchmarked them against CSF biomarker tests. Samples from 998 individuals [mean (range) age 68.5 (20.0-92.5) years, 53% female] from the Swedish BioFINDER-2 cohort, including both cognitively unimpaired and cognitively impaired individuals, were analysed. Plasma p-tau217 was measured with mass spectrometry assays [the ratio between phosphorylated and non-phosphorylated (%p-tau217WashU) and p-tau217WashU] and …

Plant-Nanoparticles Enhance Anti-Pd-L1 Efficacy By Shaping Human Commensal Microbiota Metabolites, Yun Teng, Chao Luo, Xiaolan Qiu, Jingyao Mu, Mukesh K Sriwastva, Qingbo Xu, Minmin Liu, Xin Hu, Fangyi Xu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Maiying Kong, Zhanxu Liu, Xiang Zhang, Raobo Xu, Jun Yan, Michael L Merchant, Craig J Mcclain, Huang-Ge Zhang

Faculty, Staff and Student Publications

Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. Here we investigate the impact of plant-derived nanoparticles (PNP) on gut microbiota and metabolites in context of cancer immunotherapy with the humanized gnotobiotic mouse model. Specifically, we show that ginger-derived exosome-like nanoparticle (GELN) preferentially taken up by Lachnospiraceae and Lactobacillaceae mediated by digalactosyldiacylglycerol (DGDG) and glycine, respectively. We further demonstrate that GELN aly-miR159a-3p enhances anti-PD-L1 therapy in melanoma by inhibiting the expression of recipient bacterial phospholipase C (PLC) and increases the accumulation of docosahexaenoic acid …

Antitumor Activity And Biomarker Analysis For Trop2 Antibody-Drug Conjugate Datopotamab Deruxtecan In Patient-Derived Breast Cancer Xenograft Models, Funda Meric-Bernstam, Erkan Yuca, Kurt W Evans, Ming Zhao, Takanori Maejima, Tsuyoshi Karibe, Maria Gabriela Raso, Ximing Tang, Xiaofeng Zheng, Yasmeen Qamar Rizvi, Argun Akcakanat, Stephen M Scott, Bailiang Wang, Lauren A Byers, Debu Tripathy, Daisuke Okajima, Senthil Damodaran

Faculty, Staff and Student Publications

PURPOSE: Datopotamab deruxtecan (Dato-DXd) is a humanized anti-trophoblast cell-surface antigen-2 (TROP2) IgG1 mAb linked to a potent topoisomerase I inhibitor payload (DXd). Dato-DXd has already shown antitumor activity in breast cancer; however, the determinants of response, including the importance of TROP2 expression, remain unclear. We tested the activity of Dato-DXd in a panel of breast cancer patient-derived xenografts (BCX) varying in TROP2 expression.

EXPERIMENTAL DESIGN: The antitumor activity of Dato-DXd and isotype-control-DXd (IgG-DXd) was assessed against 11 BCXs varying in TROP2 expression, 10 representing tumors postneoadjuvant chemotherapy. Pharmacodynamic effects were assessed at 24 and 72 hours. The effects of TROP2 …

Advances In The Development Of Mitochondrial Pyruvate Carrier Inhibitors For Therapeutic Applications, Henry Politte, Lingaiah Maram, Bahaa Elgendy

2020-Current year OA Pubs

The mitochondrial pyruvate carrier (MPC) is a transmembrane protein complex critical for cellular energy metabolism, enabling the transport of pyruvate from the cytosol into the mitochondria, where it fuels the citric acid cycle. By regulating this essential entry point of carbon into mitochondrial metabolism, MPC is pivotal for maintaining cellular energy balance and metabolic flexibility. Dysregulation of MPC activity has been implicated in several metabolic disorders, including type 2 diabetes, obesity, and cancer, underscoring its potential as a therapeutic target. This review provides an overview of the MPC complex, examining its structural components, regulatory mechanisms, and biological functions. We explore …

Efficacy And Safety Of Zilucoplan In Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial, Sabrina Paganoni, Timothy M Miller, Et Al.

2020-Current year OA Pubs

IMPORTANCE: The etiology of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, is unknown. However, neuroinflammation and complement activation may play a role in disease progression.

OBJECTIVE: To determine the effects of zilucoplan, an inhibitor of complement C5, in individuals with ALS.

DESIGN, SETTING, AND PARTICIPANTS: Zilucoplan was tested as regimen A of the HEALEY ALS Platform Trial, a phase 2 to 3 multicenter, randomized, double-blind, placebo-controlled perpetual platform clinical trial with sharing of trial infrastructure and placebo data across multiple regimens. Regimen A was conducted from August 17, 2020, to May 4, 2022. A total of 162 participants were …

Differential Impact Of Lymphatic Outflow Pathways On Cerebrospinal Fluid Homeostasis, Zachary Papadopoulos, Leon C D Smyth, Igor Smirnov, Daniel A Gibson, Jasmin Herz, Jonathan Kipnis

2020-Current year OA Pubs

Dysfunctional lymphatic drainage from the central nervous system (CNS) has been linked to neuroinflammatory and neurodegenerative disorders, but our understanding of the lymphatic contribution to CNS fluid autoregulation remains limited. Here, we studied forces that drive the outflow of the cerebrospinal fluid (CSF) into the deep and superficial cervical lymph nodes (dcLN and scLN) and tested how the blockade of lymphatic networks affects CNS fluid homeostasis. Outflow to the dcLN occurred spontaneously in the absence of lymphatic pumping and was coupled to intracranial pressure (ICP), whereas scLN drainage was driven by pumping. Impaired dcLN drainage led to elevated CSF outflow …

Streaming Media Platforms And Film/Video Arts Distribution, Aras Ozgun, Andreas Treske

Markets, Globalization & Development Review

Streaming media platforms have emerged as new and natively digital forms of content delivery for mainstream news and entertainment media over the past decades. Underlying technologies also unfold new possibilities for the circulation artistic/creative digital video works. Yet, such potential remains relatively underexplored, due to the complexities involved in the public distribution of such works. In this study, we analyze these complexities and critically evaluate emerging models, such as open access streaming media platforms, subscription-based platforms, and cryptocurrency and NFT-based platforms that feature new administrative forms and governance strategies. We finally discuss the possible roles of traditional public cultural institutions …

Exploring Single Cell Microbial Protein As A Sustainable Fishmeal Alternative In Yellowtail Kingfish (Seriola Lalandi) Diets: Impacts On Health And Gut Microbiome, Luke Pilmer, Lindsey Woolley, Alan Lymbery, Chinh Dam, Abigail Elizur, Md Javed Foysal, Gavin Partridge

Fisheries Research Articles

Background

With the global expansion of aquaculture and the increasing demand for fish meal, identifying appropriate and sustainable alternative protein sources for aquafeeds has become essential. Single-cell protein (SCP), derived from methanotrophic bacteria, presents a promising alternative by converting methane into protein, potentially addressing both the need for alternative protein sources and reducing industrial greenhouse gas emissions. This study aimed to evaluate the effects of different levels of SCP inclusion (0%, 25%, 50%, and 75% fish meal replacement) on the health, gene expression, and gut microbiome of yellowtail kingfish (YTK, Seriola lalandi) following a 35-day growth trial.

Results

The …

Investigating The In Vivo Effects Of Anti-Prion Protein Nanobodies On Prion Disease With Aav Vector, Jingjing Zhang, Mengfei Wang, Dan Wang, Xiangyi Zhang, Yue Ma, Els Pardon, Jan Steyaert, Romany Abskharon, Fei Wang, Jiyan Ma

Faculty, Staff and Student Publications

Prion diseases are fatal neurodegenerative disorders affecting humans and animals, and the central pathogenic event is the conversion of normal prion protein (PrPC) into the pathogenic PrPSc isoform. Previous studies have identified nanobodies that specifically recognize PrPC and inhibit the PrPC to PrPSc conversion in vitro. In this study, we investigated the potential for in vivo expression of anti-PrPC nanobodies and evaluated their impact on prion disease. The coding sequences of three nanobodies were packaged into recombinant adeno-associated virus (rAAV) and were administered via intracerebroventricular (ICV) injection in newborn mice. We found that the expression of these nanobodies remained robust …

Dairy Consumption And The Colonic Mucosa-Associated Gut Microbiota In Humans-A Preliminary Investigation, Ellie Chen, Nadim J Ajami, Donna L White, Yanhong Liu, Shawn Gurwara, Kristi Hoffman, David Y Graham, Hashem B El-Serag, Joseph F Petrosino, Li Jiao

Faculty, Staff and Students Publications

Background: Dairy consumption has been associated with various health outcomes that may be mediated by changes in gut microbiota.

Methods: This cross-sectional study investigated the association between the colonic mucosa-associated gut microbiota and the self-reported intake of total dairy, milk, cheese, and yogurt. A total of 97 colonic mucosal biopsies collected from 34 polyp-free individuals were analyzed. Dairy consumption in the past year was assessed using a food frequency questionnaire. The 16S rRNA gene V4 region was amplified and sequenced. Operational taxonomic unit (OTU) classification was performed using the UPARSE and SILVA databases. OTU diversity and relative abundance were compared …

Cardiovascular Disease In Adults With Osteogenesis Imperfecta: Clinical Characteristics, Care Recommendations, And Research Priorities Identified Using A Modified Delphi Technique, Lars Folkestad, Siddharth K Prakash, Sandesh C S Nagamani, Niels Holmark Andersen, Erin Carter, Jannie Dahl Hald, Riley J Johnson, Bente Langdahl, Eleanor M Perfetto, Cathleen Raggio, Stuart H Ralston, Robert A Sandhaus, Oliver Semler, Laura Tosi, Eric Orwoll

Faculty, Staff and Student Publications

Osteogenesis imperfecta (OI) is a multisystem disorder most often caused by pathogenic variants in genes that encode type I collagen. Type I collagen is abundant not only in bone but also in multiple tissues including skin, tendons, cornea, blood vessels, and heart. Thus, OI can be expected to affect cardiovascular system, and there are numerous reports of cardiovascular disease (CVD) in people with OI. However, there is no consensus on how CVD in OI should be assessed or managed. To fill this gap, a multidisciplinary group was convened to develop clinical guidance. The work included a systematic review of the …

Frameworks For Measuring Regenerative Tourism: Supply And Demand Indicators With A Dynamic And Holistic Approach, Asif Hussain

Journal of Sustainability and Resilience

This paper examines regenerative tourism as a holistic approach that goes beyond sustainability by actively restoring and enhancing social-ecological systems. Recognizing tourism’s interconnectedness with economic, social, cultural, and environmental systems, it presents regenerative tourism as a dynamic model integrating supply and demand perspectives to promote innovation, resilience, and renewal. On the supply side, regenerative tourism emphasizes ecological restoration, sustainable practices, economic stability with minimal environmental harm, and authentic experiences. On the demand side, it aligns with the rising preference for ethical, participatory, and immersive tourism, involving tourists as active contributors to destination well-being. The paper highlights the importance of multidimensional …

A Review On Exploring Artificial Intelligence Applications, Advancements, Issues, And Future Challenges, Sajid Naeem, Novman Nabeel, Waseem Beg, Shujaat Ali, Rajiv N. Kanojiya, Satish S. Mandawade, Chetan R. Yewale, Sc Kulkarni, Vt Salunke, Av Patil

Polytechnic Journal

Artificial intelligence (AI) is a transformative technology with diverse applications that is transforming several industries. AI is the use of systems and technology to replicate human intelligence and solve common real-world issues. Machine learning (ML) and deep learning are AI technologies that use algorithms to more accurately predict occurrences without the need for human intervention. Explainable Artificial Intelligence (XAI) refers to AI that can explain decisions or forecasts to human users. XAI seeks to improve AI systems' transparency, trustworthiness, and accountability, particularly when utilized in high-risk applications such as healthcare, finance, or security. This review article provides a thorough overview …

Blended Learning Course In Medical Affairs To Improve Exposure And Interest In Pharmaceutical Industry Careers, Nandini Manne, Gayle Brazeau, Craig Kimble

Pharmacy Practice & Administration

Objective: This study aimed to evaluate students’ knowledge and perceptions of career options and their knowledge of the pharmaceutical industry based on pre-post module quizzes, reflections, and team presentations in a hybrid medical affairs elective certification course.

Methods: A qualitative research design was used to analyze the reflections of 19 students enrolled in the Accreditation Council for Medical Affairs Pharmaceutical Industry Training Certificate elective at Marshall University during spring 2023. The course used 7 modules from the Medical Affairs Competency Certificate offered by the Accreditation Council for Medical Affairs. Students completed premodule and postmodule quizzes, engaged in discussions with industry …

Book Review: Alebrijes, Shauna Christensen

The Utah English Journal

400 years into the post-apocalyptic future, 13 year-old orphan Leandro and his younger sister, Gabi, struggle to survive in a barren San Joaquin Valley. Like the other Spanish-speaking lower class field workers, they are forced to farm vegetables for the elite ruling class, or risk exile or death in the harsh desert, a barren wasteland filled with terrifying man-eating wyrms. Leandro’s plan to escape with Gabi is thrown into disarray when Gabi is caught stealing a single strawberry in the market. Leandro takes the blame and is sentenced to banishment, or he can choose to have his consciousness transferred to …

A Cohort Of The Willing: How Secondary Schools Might Face The Literacy Crisis, Michelle A. Barney

The Utah English Journal

Experts like Louisa Moats and anyone who has recently completed LETRS (Language Essentials for Teachers of Reading and Spelling) training, know that 95% of children can be taught to read (Louisa Moats, 2023). As a secondary educator, it’s tempting to see this statistic and ignore it. Surely, this must be someone else’s problem. In fact, if all goes according to plan in the world of elementary education, students become proficient at foundational reading skills before fourth grade, especially if one considers Kilpatrick’s work which establishes this benchmark for the development of advanced phonological awareness skills (Kilpatrick, 2015, p. …

Examining Tension Management Of Coastal Residents' Decisions To Stay Or Leave During Hurricane Florence, Andrew S. Pyle, Ryan P. Fuller, Hillary Smith

Publications

This study examines how coastal residents in the path of a hurricane manage the tension to evacuate or stay. In interviews with 17 coastal residents, we found evidence of tension management through account giving. Stayers justified their choices as keeping close to loved ones and animals, reducing difficulties in returning, and benchmarking prior storms to guide their actions over other sources of information. Evacuees framed the tension as either the only choice or the better of two poor choices. Our analysis also revealed contradictions in evacuating: a case of haves (have resources to evacuate but do not) and have nots …

Primal Leadership In Healthcare: A Phenomenological Study Of Emergency Medicine Physicians And Their Perspective On Effective Leadership, Zoe Zaidi

Dissertations

Purpose: The purpose of this qualitative study was to identify and describe how emergency medicine (EM) physicians in leadership roles use the six EI leadership competencies related to relationship management (inspiration, influence, developing others, change catalyst, conflict management, and teamwork and collaboration) to lead teams and accomplish effective results. Methodology: This phenomenological study described the lived experiences of emergency medicine (EM) physician leaders in San Bernadino, Riverside, and Orange counties in Southern California. The participants were selected through nonprobability purposeful sampling and met the criteria “as leaders” for achieving effective results. Data were collected through semistructured interview questions and analysis …

Icipe Monthly Digest – Volume 1, Issue 2, February 2025, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Newsletters

No abstract provided.

Attitudes Toward The Continued Protection Of Grizzly Bears Under The Endangered Species Act, John A. Vucetich, Jeremy T. Bruskotter

Michigan Tech Publications

In January 2025, the U.S. Fish & Wildlife Service published a proposed rule to continue protecting grizzly bears in the contiguous United States under the Endangered Species Act (ESA). The proposed rule and guidance for how the public can comment on the proposed rule can be found at this link: https://www.fws.gov/press-release/2025-01/usfws-proposes-update-grizzly-bear-esa-listing-management

In January 2025, we implemented a web-based survey designed to assess the attitudes of residents of the contiguous United States, as they pertain to the appropriateness of continuing protection of grizzly bears under the ESA. A large body of prior research indicates that individuals’ attitudes toward species protections can …

Book Review: Monstrous: A Transracial Adoption Story, Amanda Thomas

The Utah English Journal

Sarah is a little girl with a vibrant inner life and explosive energy and creativity. From her first realization that The Little Mermaid was made by teams of artists drawing thousands of illustrations, she sees life and power in her art. Sarah relies on that power as she navigates the confusing and sometimes harsh realities of being one of few non-white kids growing up in her small Maryland town. Adopted from Korea as an infant, Sarah struggles to understand how she is different from the other kids and even from her older adopted sister, Liz (also from Korea). Every time …

Issue 460: February 2025, The Local Voice

The Local Voice

No abstract provided.

Issue 459: February 2025, The Local Voice

The Local Voice

No abstract provided.

Book Review: There Goes The Neighborhood, Feliciana Lopez-Goodman

The Utah English Journal

Rhea’s motives seem simple—save her best friend from eviction and stop the neighborhood from falling apart. As is true for all complex characters, there is more to Rhea, Zeke, and Malachi as they create a fake gang in their South LA neighborhood of Kofa Park. In Jade Adia’s debut novel There Goes the Neighborhood, gentrification is front and center as three teenagers take on the responsibility of saving their neighborhood and their chosen family.