Digital Commons Network^™

Novel Approach For Women’S Self-Management Of Rectal Emptying Difficulty, Sharon Eustice, Ruth Endacott, Bridie Kent

School of Nursing and Midwifery

Aim To pragmatically investigate rectal emptying difficulty in women to identify if managing their symptoms with an innovative device is more effective and satisfactory than their usual care. Background Rectal emptying difficulty has a mostly unknown influence on women and frequently a hidden issue. Self-management alternatives are underappreciated. Despite the magnitude of the problem and its influence on women’s lives and healthcare, non-surgical alternatives have received little attention. Methods This cohort study of 35 female participants, recruited via secondary care outpatient clinics, used composite questionnaires before and after an 8-week intervention using the device. The questionnaire comprised of a quality …

Retinoic Acid Antagonizes Estrogen Signaling To Maintain Adult Uterine Cell Fate, Yan Yin, Meade Haller, Lauren Goldinger, Shivani Bharadwaj, Emily So, Vivian Robles-Pinos, David Chen, Liang Ma

2020-Current year OA Pubs

Classical tissue recombination experiments demonstrate that cell-fate determination along the anterior-posterior axis of the Müllerian duct occurs prior to postnatal day 7 in mice. However, little is known about how these cell types are maintained in adults. In this study, we provide genetic evidence that a balance between antagonistic retinoic acid (RA) and estrogen signaling activity is required to maintain simple columnar cell fate in adult uterine epithelium. Transdifferentiation of simple columnar uterine epithelium into stratified cervicovaginal-like epithelium was observed in three related mouse genetic models, in which RA signaling was perturbed in the postnatal uterus. Single-cell RNA sequencing analysis …

Exenatide Once A Week Versus Placebo As A Potential Disease-Modifying Treatment For People With Parkinson's Disease In The Uk: A Phase 3, Multicentre, Double-Blind, Parallel-Group, Randomised, Placebo-Controlled Trial, Nirosen Vijiaratnam, Christine Girges, Grace Auld, Rachel Mccomish, Alexa King, Simon S Skene, Steve Hibbert, Alan Wong, Sabina Melander, Rachel Gibson, Helen Matthews, John Dickson, Camille Carroll, Abigail Patrick, Jemma Inches, Monty Silverdale, Bethan Blackledge, Jessica Whiston, Michele Hu, Jessica Welch, Gordon Duncan, Katie Power, Sarah Gallen, Jacqueline Kerr, K Ray Chaudhuri, Lucia Batzu, Silvia Rota, Edwin Jabbari, Huw Morris, Patricia Limousin

Peninsula Medical School

Background: GLP-1 receptor agonists have neurotrophic properties in in-vitro and in-vivo models of Parkinson's disease and results of epidemiological studies and small randomised trials have suggested possible benefits for risk and progression of Parkinson's disease. We aimed to establish whether the GLP-1 receptor agonist, exenatide, could slow the rate of progression of Parkinson's disease. Methods: We did a phase 3, multicentre, double-blind, parallel-group, randomised, placebo-controlled trial at six research hospitals in the UK. Participants were aged 25–80 years with a diagnosis of Parkinson's disease, were at Hoehn and Yahr stage 2·5 or less when on dopaminergic treatment, and were on …

Identifying Research-Based Practices For Increasing Peer Interaction In Children With Hearing Impairment: A Review Of The Literature, Amal Aldawoud

International Journal for Research in Education

Establishing peer interaction is critical for all childhood development, especially for children with hearing impairment (HI), who tend to experience a lot of difficulties in interaction. Practices aiming to promote peer interaction in children with HI need to be informed by evidence from quality research. This paper aims to review and evaluate research studies that focus on interaction between children with HI and their peers (with or without HI) in self-contained and inclusive classrooms. Seven empirical studies published in peer-reviewed journals from 1990 to 2023 were examined and evaluated, using the Council for Exceptional Children (CEC, 2014) quality indicators. Several …

Large Language Model Based Story Generation On A Television, Aravind Reddy Ayuluri, Venkata Gangadhar Kanchu

Defensive Publications Series

Many users may want to create and publish original media content for sharing and viewing by others. One way of doing so may include the use of specialized equipment such as cameras, microphones, tripods, lighting systems, sound mixing systems, a green screen, audio editing software, graphic design software, and a computer capable of working with and interfacing to the specialized equipment and systems. Because of the high cost and possible financial burden, the average user may not own or have access to specialized equipment. Therefore, the user may not be able to create and publish original media content in the …

Towards A Biblical Theology Of Natural Theology, Armen Oganessian

Liberty Theological Review

This article aims to construct a biblical theology of natural theology through an examination of the Book of Job. This examination will employ a three-pronged approach. Firstly, it will place the Book of Job within the overarching redemptive-historical narrative of Scripture. Secondly, it will analyze the book's structure, viewing it as crucial for interpreting its message on natural theology. Finally, it will examine Job's dialogue with his companions (chapters 3:1-31:40) as a discussion of natural theology. This tripartite analysis will demonstrate that Job’s author prompts readers to assess the conversation between Job and his friends within the framework of the …

Public Theology And Political Polarization: Environmental Policy, Jean Golicz, Leonard S. Momeny

Liberty Theological Review

The purpose of this article is to explore the impact of public theology on potentially polarizing political views. Specifically, the historical and contemporary interpretations of the Lynn White Thesis (1966) are examined as well as the practical implications for developing environmental policies that align with a biblical worldview. The authors propose the application of multiple paradigms to the study of religiosity and environmental activism as a way of addressing the complexity and diversity of various viewpoints. Understanding the multiple ways Jesus operated in an equally contentious and polarized society creates a path forward for churches. By rejecting the supposition that …

James' Warning Against Inauthentic Faith: Confronting The Actions Of The Wealthy (James 5:1-6), Joseph Daniel Peters, Bradley Wayne Ellison

Liberty Theological Review

The primary message of James is that one’s faith should be reflected by their actions. The author of James argues that helping the needy is what pure religion and genuine faith looks like (1:27; 2:14-18). He contrasts this with his description of the wealthy who oppress the poor by hoarding their wealth and defrauding their employees of their wages (5:1-6). The author criticizes the oppressive and greedy actions of the wealthy, arguing that their actions will testify against them and lead to their misery. One major question is whether these wealthy are within the church (i.e., self-identify as Christians). If …

Defending The Doctrine Of Hell, Jordan P. Ballard

Liberty Theological Review

The doctrine of hell, or the final state of the wicked, has become one of the most objectionable Christian doctrines because it depicts God as vengeful and wrathful, which is offensive to human sensibilities. As an extension of the problem of evil, where God is put on trial for allowing what may appear to be gratuitous pain and suffering in the world, many Christians and non-Christians alike wonder how a loving God could consign people to suffering in hell forever. After all, why didn’t God make a world where all would be saved if He is truly loving? Belief in …

A Man After Yahweh-Chemosh's Own Heart: Syncretism And Davidic Allusions In The Story Of Jephthah, J. Christian Doling

Liberty Theological Review

Jephthah's story has caused no small amount of confusion among scholars as they wrestle with what to make of Jephthah's oath and subsequent sacrifice of his daughter. Some have believed that Jephthah was acting in accordance with Yahweh's wishes, others believe that he was acting out of selfish interest. However, there are two aspects of the literary makeup of the Jephthah story that can help shed some light on the subject. Firstly, the story is filled with Davidic allusions, and the second aspect is syncretism. The Davidic allusions paint Jephthah as a prefigurement of David. In other words, David and …

A Review Examining The Factors Contributory To The Socialization Of A Culture Of Environmental Stewardship, Colby Nixon

Undergraduate Research and Engagement Symposium

Environmental stewardship is an ambiguous but significant term meaning that responsibility for the environment — and its quality — is shared between all individuals who interact with it. As a culture-wide phenomena, it is correlated with a mutualistic relationship with nature and the Earth. My study responds to a question as to which and how variables contribute to a societal mindset of environmental stewardship. This review synthesizes numerous studies across diverse cultures and contexts to examine trends therein. In doing so, I discovered that religion, policy, human development, linguistics, and economic roles play a part in socializing environmental stewardship into …

Insilico Evaluation Of The Therapeutic Effects Of N1-(5-(3-Imino-2,4a-Dihydro-3h-Benzo[F]Chromen-2-Yl)-1,3,4-Thiadiazol-2-Yl)-N10-(5-(3-Imino-3h-Benzo[F]Chromen-2-Yl)-1,3,4-Thiadiazol-2-Yl)Decanediamide As Anti-Hepatitis B And C Agent, Moses M. Edim, Njok N. Okam, Nguuma I. Gber, Jessica E. Egbelo, Israel E. Okon, Chiemerie P. Ogbonna, Emmanuel K. Aidoo, Kenneth N. Chisom, Emmanuel Samuel

Polytechnic Journal

Hepatitis B and C viruses are a major cause of cirrhosis and hepatocellular carcinoma, with significantly increasing mortality and morbidity worldwide. This study provides a detailed analysis of the therapeutic effects of N1-(5-(3-imino-2,4a-dihydro-3H-benzo[f]chromen-2-yl)-1,3,4-thiadiazol-2-yl)-N10-(5-(3-imino-3H-benzo[f]chromen-2-yl)-1,3,4-thiadiazol-2-yl) decan diamide (PRO_16) as an anti-hepatitis B and C virus. A computational DFT was applied via the ωB97XD method of theory and a basis set of 6-311G++ (2d, 2p) to evaluate the quantum mechanics of the compound. A time-dependent self-consistent field DFT method with the aforementioned functional and basis set was utilized for UV‒visible evaluation. Additionally, a molecular docking technique and ADMET prediction were used to elucidate …

Lanthorn, Vol. 59, No. 11, January 20, 2025, Grand Valley State University

Volume 59, August 5, 2024 – April 14, 2025

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

C.S. Lewis And Christian Faith, Michael Peterson

Syllabi

No abstract provided.

Basic Christian Doctrine, Joel Chopp

Syllabi

No abstract provided.

The Human Person: Multidisciplinary Perspectives, Joel Chopp

Syllabi

No abstract provided.

A Multiple-Case Study Of Nature Center Programs, Events, And Service Adaptations In Response To Emerging Community Needs, Amy C. Bonnette

Graduate Dissertations and Theses

Urban nature centers across the United States provide access to outdoor education and safe places to explore the natural environment. The purpose of this qualitative, multiple-case study was to analyze programs, events, and services in response to emerging needs identified by urban nature center administrators in the southeastern United States. This study addressed the central research question, “How have urban nature center administrators in the southeastern United States identified emerging needs and wants of stakeholders, responded to these emerging needs and wants through changes in programming, events, and services offered, and to what extent it has affected their mission?” The …

The Utah Statesman, February 3, 2025, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Rider (2025-02-03), Rebeca Salinas

The Rider Archives

Vol.10 No.17

Seminar One: Kenotic Leadership, Aaron Perry

Syllabi

No abstract provided.

Faculty And Staff Library News - Early Spring 2025, Rit Libraries

RIT Digital Archives

No abstract provided.

Restoring The Soul To Birthing In Miami: A Call For Justice For Obstetric Racism In Miami–Dade County, Jordan Brooks, Jamarah Amani, Sannisha Dale, Dr. Karen A. Scott

University of Miami Race & Social Justice Law Review

For far too many Black mothers and birthing people, U.S. hospitals are dangerous and fail to keep our Black mothers and birthing people and their babies safe, alive, and thriving during and after childbirth. The confluence of medical racism and obstetric violence—obstetric racism—leads to a disproportionate rate of predictable, preventable, and unfair death, sickness, and trauma for Black birthing people and babies in the afterlife of slavery. Obstetric racism, as defined by Davis, is both an analytic and phenomenon that describes mechanisms of subordination, control, and dominance to which Black mothers and birthing people are subjected by health systems and …

Lake Powell Fish Sampling: Glen Canyon Dam Forebay Area, 2022 And 2023, Phaedra Budy, Casey Pennock

Browse all Datasets

Native fishes face imperilment due to habitat loss and fragmentation, megadrought, invasive species, and synergies amongst threats. These threats coalesce at Glen Canyon Dam (GCD), which impounds the Colorado River to create Lake Powell, a reservoir inhabited by a suite of nonnative fishes. Water level in Lake Powell has declined precipitously due to water overallocation and megadrought, increasing the risk of nonnative fish entrainment through the dam, as the penstocks draw water from the epilimnion. Our goal was to characterize the distribution and abundance of nonnative fishes in the vicinity of GCD and identify environmental conditions that may increase entrainment. …

Basic Christian Doctrine, Thomas Mccall

Syllabi

No abstract provided.

Seminar One: The Pastor Formed Through Preaching, Jessica Lagrone

Syllabi

No abstract provided.

(Winter Skate (Leucoraja Ocellata)) Jaw, Michael A. Birnbaum, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Generating Real-Time Synthetic Datasets To Improve Aerial Object Detection, Garrett Williams

Theses and Dissertations

The widespread use of unmanned aerial vehicles (UAVs) across civilian and military applications has necessitated the advancement of real-time drone detection and tracking capabilities. Machine Learning (ML) addresses these requirements, however, to train a robust and generalizable model requires large and diverse video datasets. Curating these real-world datasets is often time-consuming and cost-prohibitive. Here, we present DyViR, a real-time customizable rendering application capable of automatically generating highly realistic synthetic, multi-modal video of aerial objects, digital environments, and automatic generation and labeling of bounding boxes. Synthetic data, coupled with real-world training sets, augment the ML training process, leading to increased performance …

Reassessing Haydn’S Orfeo In The Theatre, Dorian Bandy, Caryl Clark

HAYDN: Online Journal of the Haydn Society of North America

Haydn’s last opera, L’anima del filosofo (The Soul of the Philosopher), is a highly unusual retelling of the Orpheus myth. Written for London in 1791 to a libretto by C. F. Badini, the opera was never staged during the composer’s lifetime. Shut down in rehearsal and banned from performance, the opera never reached the stage because many of its themes—including the apocalyptic storm at the end—piqued British anxieties towards events unfolding in revolutionary France. The opera finally premiered in 1951, with Maria Callas singing the role of Euridice. Universal Edition prepared the performing material from sources photographed behind …

Adoption Of Improved Crop Varieties Limited Biodiversity Losses, Terrestrial Carbon Emissions, And Cropland Expansion In The Tropics, Uris Baldos, Alfredo Cisneros-Pineda, Keith O. Fuglie, Thomas Hertel

Department of Agricultural Economics Faculty Publications

Research investments in crop improvements, including by national and international agricultural research centers, have made significant contributions to raising yields of staple food crops in developing countries. Although mostly intended to improve food security and rural incomes, innovations in crop production also have major implications for the environment. Building on the latest productivity estimates from historical crop improvements in developing countries and using a gridded (0.25 degrees) equilibrium model of global agriculture, we assess the impacts of improved crop varieties on cropland use, threatened biodiversity, and terrestrial carbon stocks over 1961–2015. We replicate a historical baseline and produce a counterfactual …

Cancer Cells Avoid Ferroptosis Induced By Immune Cells Via Fatty Acid Binding Proteins, Maria Angelica Freitas-Cortez, Fatemeh Masrorpour, Hong Jiang, Iqbal Mahmud, Yue Lu, Ailing Huang, Lisa K Duong, Qi Wang, Tiffany A Voss, Claudia S Kettlun Leyton, Bo Wei, Wai-Kin Chan, Kevin Lin, Jie Zhang, Efrosini Tsouko, Shonik Ganjoo, Hampartsoum B Barsoumian, Thomas S Riad, Yun Hu, Carola Leuschner, Nahum Puebla-Osorio, Jing Wang, Jian Hu, Michael A Davies, Vinay K Puduvalli, Cyrielle Billon, Thomas P Burris, Philip L Lorenzi, Boyi Gan, James W Welsh

Faculty, Staff and Student Publications

Background: Cancer creates an immunosuppressive environment that hampers immune responses, allowing tumors to grow and resist therapy. One way the immune system fights back is by inducing ferroptosis, a type of cell death, in tumor cells through CD8 + T cells. This involves lipid peroxidation and enzymes like lysophosphatidylcholine acyltransferase 3 (Lpcat3), which makes cells more prone to ferroptosis. However, the mechanisms by which cancer cells avoid immunotherapy-mediated ferroptosis are unclear. Our study reveals how cancer cells evade ferroptosis and anti-tumor immunity through the upregulation of fatty acid-binding protein 7 (Fabp7).

Methods: To explore how cancer cells resist immune cell-mediated …