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Spartan Daily, February 18, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 11

Could Eras Protocols Be Integrated Into The National Standards For Quality In Healthcare In Türkiye?, Mi̇ne Gürsaç Çeli̇k, Adem Az, Mehmet Çeti̇n, Nesli̇han Alkiş

Turkish Journal of Medical Sciences

No abstract provided.

Single-Cell Analysis Of Neoplastic Plasma Cells Identifies Myeloma Pathobiology Mediators And Potential Targets, Luz Yurany Moreno Rueda, Hua Wang, Keiko Akagi, Minghao Dang, Amishi Vora, Li Qin, Hans C Lee, Krina K Patel, Pei Lin, David E Mery, Fenghuang Zhan, John D Shaughnessy, Qing Yi, Yang Song, Bo Jiang, Maura L Gillison, Sheeba K Thomas, Donna M Weber, Lixia Diao, Jing Wang, Isere Kuiatse, Elisabet E Manasanch, David E Symer, Robert Z Orlowski

Faculty, Staff and Student Publications

Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138+ cells. By combining single-cell RNA sequencing (scRNA-seq) with scB-cell receptor sequencing (scBCR-seq), we differentiate monoclonal/neoplastic from polyclonal/normal PCs and find more dysregulated genes, especially in precursor patients, than we would have by analyzing bulk PCs. To determine whether this approach can identify oncogenes that contribute to disease pathobiology, mitotic arrest deficient-2 like-1 (MAD2L1) and S-adenosylmethionine synthase isoform type-2 (MAT2A) are validated as targets with drug-like molecules that suppress myeloma growth in preclinical models. Moreover, functional studies show a …

Mitochondrial Defects And Metabolic Vulnerabilities In Lynch Syndrome-Associated Msh2-Deficient Endometrial Cancer, Mikayla Borthwick Bowen, Brenda Melendez, Qian Zhang, Diana Moreno, Leah Peralta, Wai Kin Chan, Collene Jeter, Lin Tan, M Anna Zal, Philip L Lorenzi, Kenneth Dunner, Richard K Yang, Russell R Broaddus, Joseph Celestino, Nisha Gokul, Elizabeth Whitley, Deena M Scoville, Tae Hoon Kim, Jae-Wook Jeong, Rosemarie Schmandt, Karen Lu, Hyun-Eui Kim, Melinda S Yates

Faculty, Staff and Student Publications

Lynch syndrome (LS), caused by inherited mutations in DNA mismatch repair genes, including MSH2, carries a 60% lifetime risk of developing endometrial cancer (EC). Beyond hypermutability, mechanisms driving LS-associated EC (LS-EC) remain unclear. We investigated MSH2 loss in EC pathogenesis using a mouse model (PR-Cre Msh2LoxP/LoxP, abbreviated Msh2KO), primary cell lines, human tissues, and human EC cells with isogenic MSH2 knockdown. By 8 months, 58% of Msh2KO mice developed endometrial atypical hyperplasia (AH), a precancerous lesion. At 12-16 months, 50% of Msh2KO mice exhibited either AH or ECs with histologic similarities to human LS-ECs. Transcriptomic profiling of EC from Msh2KO …

Natural And Bioengineered Extracellular Vesicles In Diagnosis, Monitoring And Treatment Of Cancer, Xin Luo, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) are cell derived nanovesicles which are implicated in both physiological and pathological intercellular communication, including the initiation, progression, and metastasis of cancer. The exchange of biomolecules between stromal cells and cancer cells via EVs can provide a window to monitor cancer development in real time for better diagnostic and interventional strategies. In addition, the process of secretion and internalization of EVs by stromal and cancer cells in the tumor microenvironment (TME) can be exploited for delivering therapeutics. EVs have the potential to provide a targeted, biocompatible, and efficient delivery platform for the treatment of cancer and other …

Nanrilkefusp Alfa (Sot101), An Il-15 Receptor Βγ Superagonist, As A Single Agent Or With Anti-Pd-1 In Patients With Advanced Cancers, Stephane Champiat, Elena Garralda, Vladimir Galvao, Philippe A Cassier, Carlos Gomez-Roca, Iphigenie Korakis, Peter Grell, Aung Naing, Patricia Lorusso, Romana Mikyskova, Nada Podzimkova, Milan Reinis, Kaissa Ouali, Andreu Schoenenberger, Joachim Kiemle-Kallee, Sascha Tillmanns, Richard Sachse, Ulrich Moebius, Radek Spisek, David Bechard, Lenka Palova Jelinkova, Irena Adkins, Aurelien Marabelle

Faculty, Staff and Student Publications

Nanrilkefusp alfa (nanril; SOT101) is an interleukin (IL)-15 receptor βγ superagonist that stimulates natural killer (NK) and CD8

Application Of Quantum Dot Immunochromatography In Rapid Detection Of Veterinary Drug Residues, Song Qianzhao, Wang Yao, Hu Xiaofei, Cao Li, Sun Yaning

Food and Machinery

In recent years,immunochromatography has been a key player in the field of rapid detection of food of animal origin,providing a strong guarantee for the efficient supervision of veterinary drug residues.As a new type of fluorescent material,quantum dots can be used as a marker material in immunochromatographic detection,which can effectively improve the detection performance and has broad application prospects in the research field of rapid detection technology.This paper summarized the classification,synthesis,and preparation of immune probes of quantum dots,reviewed the application of quantum dot -based immunochromatographic assay in the rapid detection of veterinary drug residues in animal -derived food,prospected the research of …

The Current Situation , Challenges And Responses To Hidden Hunger Among Chinese Residents, Liu Rui, Huang Jiazhang, Miao Yiyuan, Sun Junmao, Sheng Jiping, Wang Zhihong, Yin Shutao, Yu Huanling, Nie Ying

Food and Machinery

The problem of hidden hunger is a common challenge facing the world.In recent years,China has actively responded to the problem of hidden hunger,and the problem of hidden hunger has been significantly improved.The article summarizes the concept and connotation of hidden hunger,the current situation of hidden hunger in various countries around the world,the important measures and achievements of China in dealing with hidden hunger,and the challenges still facing,and puts forward suggestions on countermeasures in the future,aiming at better promoting the realization of nutrition and health for all people and common prosperity.

Research Progress Of Near Infrared Spectroscopy In Condiments Detection, Yu Xinlei, Zhang Jiahui, Liu Taiang, Yin Mingyu, Wang Xichang

Food and Machinery

The traditional detection methods for condiments have the disadvantages of time -consuming,high cost and destructive detection,while the near infrared spectroscopy （NIRS ）is a fast,accurate,nondestructive and convenient method,which has been used in condiment industry.With the development of chemometrics,electronic information technology and instrumentation hardware,the near infrared spectroscopy is increasingly improved.This review expounds the classification and common detection methods of condiments,and summarizes the principle,characteristics and rapid detection model of NIRS.The principle,characteristics and rapid detection model of NIRS are outlined.The research progress of near infrared spectroscopy in condiment in recent years is reviewed,including ingredient detection,adulteration identification,brand traceability and quality detection.In addition,the development trend of …

Research Progress Of Plant Extracts In Preservation Of Meat Products, Li Hongyan, Xu Minglei, Zhai Saiya

Food and Machinery

Plant extracts contain natural active ingredients,offering benefits such as health,ecofriendliness,and sustainability.Traditional chemical preservatives,however,can contribute to environmental pollution and pose health risks,limiting their suitability for long -term use.This underscores the need for natural,eco-friendly preservative solutions..Plant polyphenols and essential oil are the primary plant -derived compounds currently applied in the meat industry,valued for their antioxidant and antibacterial properties.These compounds show promise as natural preservatives,potentially replacing chemical options while preserving the sensory quality and extending the shelf life of meat products.In addition to ensuring food safety and supporting essential processing qualities,plant extracts help preserve the sensory attributes of meat products,thereby extending shelf life.This …

Effects Of The Conditions Of Frozen Storage And Freeze-Thaw Treatment On The Formation Of Α-Dicarbonyl Compounds In Unwashed Silver Carp Surimi, Su Jie, Li Jiayi, Liu Yongle, Zhou Jinsong, Huang Yiqun, Li Xianghong, Wang Faxiang

Food and Machinery

［Objective］ To regulate the formation of α-dicarbonyl compounds (α-DCs ) in unwashed silver carp surimi.［Methods］ The levels of 3-deoxyglucosaldosterone (3-DG),glyoxal (GO),pyroacetal (MGO ) and 2,3-butanedione (2,3-BD) were analyzed in surimi during frozen storage and freeze -thaw cycles at -18 ℃ and -60 ℃.The effects of freezing temperature,freezing method,and the addition of an antifreeze agent (enzymatic hydrolysis product of silver carp ) on the formation of these α-DCs were evaluated.［Results］］ After 60 days of storage at -60 ℃,the levels of 3-DG,MGO and 2,3-BD increased by 209%,122% and 139%,respectively,but were significantly lower compared to storage at -18 ℃.GO levels initially increased,peaking on …

The Improving Effects Of Probiotic Fermented Tomato Juice Combined With High-Intensity Interval Training On Diabetic Cardiomyopathy In Mice, Li Yahui

Food and Machinery

［Objective］ Seeking a comprehensive therapeutic approach to address multiple pathological processes in Diabetic Cardiomyopathy (DCM ).［Methods］ Randomly divided all mice into control group,DCM group,DCM +PFTJ group,DCM +HIIT group,and DCM +PFTJ +HIIT group.Used intraperitoneal injection of streptozotocin combined with high -fat diet to treat mice,and treated them according to the experimental plan for 16 weeks.Recorded the heart weight to body weight ratio (HW/BW ),detected cardiac function using small animal ultrasound imaging system,and assessed the pathological damage of the heart by detecting the levels of lactate dehydrogenase (LDH ),creatine kinase (CK),troponin I,IL-6,IL-1β,and TNF -α in the serum,combined with hematoxylin and eosin staining.At …

Study On The Detection Of Tetracycline By Electrochemical Sensors Modified With Nanomaterials, Wang Chenyu, Li Xiaoran, Quan Ke, Liu Miao, Wang Jianhui, Chen Qijie, Zhang Bo

Food and Machinery

Tetracycline (TC) is a typical broad -spectrum antibiotic with extensive applications in fields such as food and medicine.However,its improper use can pose a threat to human health and environmental safety.Therefore,detecting the residue of tetracycline is very important.In recent years,electrochemical sensors modified with nanomaterials have been successfully applied for the detection of tetracycline residues in food and environmental samples due to their high sensitivity and fast response.This review compares the electrochemical sensors modified with different nanomaterials for tetracycline detection,aiming to provide a reference for trace analysis of tetracycline and the development of more efficient detection technology.At the same time,this review also …

Enzymatic Hydrolysates Of Mulberry Leaf Flavonoids Alleviate Depression Induced By Reserpine In Zebrafish, Zheng Xuan, Lu Yunke, Zhou Chunling, Zhang Ju, Wang Mingxue, Cui Shizhan, Jia Dongsheng

Food and Machinery

［Objective］ This study aims to investigate the anti -depression effects of enzymatic hydrolysates of mulberry leaf flavonoids (EMLF ).［Methods］ EMLF was prepared and its components were analyzed by UPLC -MS.A zebrafish model of depression was induced by 40 mg/L reserpine.Six groups were designed,including the control,model,fluoxetine,L-EMLF (20 μg/mL ),M-EMLF (40 μg/mL ),and H-EMLF (80 μg/mL ) groups.Behavioral tests,including the new tank test and the light -dark box test,were conducted.The structural changes in the brain tissue of zebrafish in each group were observed by HE staining.The mRNA levels of interleukin -1β (IL-1β),tumor necrosis factor -α (TNF-α),tryptophan hydroxylase -2 (TPH- 2),and 5-hydroxytryptamine 2A …

Study On The Physicochemical Properties And Antioxidant Capacity Of Fish Maw Digestive Juices From Pangasianodon Hypophthalmus, Feng Rui, Huang Darong, Zhong Biluan, Zhang Yu, Liang Jiehua, Tang Xiaoshu, Chen Xuemei, Tian Jianxin

Food and Machinery

［Objective］ This study aimed to investigate the impact of digestion time on the digestibility,physicochemical properties,and antioxidant activity of Pangasianodon hypophthalmus fish maw.［Methods］ In vitro digestion was performed with simulated gastric fluid and simulated small intestine fluid.The relative molecular weight,Zeta potential and amino acid composition of the digestive fluid were determined by gel permeation chromatography (GPC ),amino acid analyzer and Zeta potentiometer,and the antioxidant capacity of the digestive fluid was evaluated.［Results］］ After the combined treatment of 1.5 h gastric fluid digestion and 4 h small intestinal fluid digestion,the digestibility,i.e.the total ratio of oligopeptide and polypeptide content,the total amino acid and the …

Optimization Of Processing Technology Of Dali Ginseng And Analysis On Its Anti-Oxidation Activity, Li Genyue, Wang Yudan, Yang Kaili, Han Lusheng, Wang Enpeng

Food and Machinery

［Objective］ This study aimed to determine the optimal processing conditions for Dali ginseng (DG) and evaluate its antioxidant activity.［Methods］ Total ginsenosides content in DG was measured under different liquid -material ratios,temperatures,and extraction time.The response surface method was employed to optimize the processing conditions.UPLC -QQQ -MS was used to analyze the ginsenoside content,and the antioxidant activity of DG extracts with different polarities was evaluated using various antioxidant indexes.［Results］］ The optimal processing conditions of DG were processing at 95 ℃ with liquid -solid ratio 22∶1 (mL/g ) for 30 mins.Under the control of these conditions,the maximum content of total ginsenosides at 3.75% …

Circadian Rhythm And Its Impact On Balance And Physical Performance, Angel Oliver, Christian Mccormick, Eseosa Aigbe, Tanner Erwin, Ariela Khandadash, Benjamin Khavkin, Samuel Park, Jutta Ward, Deborah Bell-Pedersen

Annual Research Symposium

This study explores the relationship between circadian rhythms and human performance across three key domains: cardiovascular endurance, vestibular function, and strength. Through the review of data obtained through performance testing at two different time points along with 24-hour physiological tracking, this study attempts to find correlations between circadian function and physical performance.

Fecal Virome Transplantation As Treatment For Metabolic Syndrome: A Review Of Current Literature Poster For The 11th Annual Roseman Research Symposium, Giovanna Park, Julie Paik, Amy Stone Ph.D., Megan De Armond Mfa, Mslis, Sherli Koshy-Chenthittayil Ph.D., Terry Else Ph.D., Mt, Mlt, Karen Duus Ph.D.

Annual Research Symposium

Fecal Virome Transplantation as treatment for Metabolic Syndrome: A review of current literature Poster for the 11th Annual Roseman Research Symposium

Secondary Preservice Teachers’ Disciplinary Identity In Integrated Stem Collaboration, Hanan Alyami, Nathan Mentzer

Journal of STEM Teacher Education

Integrated science, technology, engineering, and mathematics (STEM) education provides opportunities for interdisciplinary collaborations. To explore the nature of interdisciplinary collaborations, we investigated the disciplinary identity of 11 secondary preservice teachers (PSTs) enrolled in a semester-long secondary integrated STEM methods course. The pedagogical approach in the course aimed to provide secondary PSTs with the opportunity to experience interdisciplinary collaboration, where secondary PSTs from different disciplines collaborate on designing and implementing integrated STEM curricula. Through positioning theory, we analyzed the PSTs’ discussion during each team’s initial collaboration meeting. Findings indicate that PSTs take a strong disciplinary identity position in their discipline. Their …

Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xxxv. Parabuthus Starhai Sp. N. From Somalia (Puntland) (Buthidae), František Kovařík

Euscorpius

A new species Parabuthus starhai sp. n. from Somalia (Puntland) is described. Combination of two characters, pectine teeth number 56–59 in both sexes and pedipalp chela length/ width ratio 3.65 in male and 5.47 in female differ P. starhai sp. n. from all other species in the region. Included is also a map of distribution of Parabuthus species in the Horn of Africa.

The Utah Statesman, February 17, 2025, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Religion And Attitudes Toward Xenotransplantation: Results Of A Nationwide Survey In The United States., Daniel J Hurst, Luz A Padilla, Amanda Zink, Brendan Parent, Laura L Kimberly

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Religious viewpoints have been shown to influence the ways in which many persons approach medical decision-making and have been noted as a potential barrier to xenotransplantation acceptance. This study sought to explore how attitudes toward xenotransplantation differ among various religious beliefs. A national Likert-scale survey was conducted in 2023 with a representative sample in the United States. Religious belief was self-reported. Regression analysis was used to identify associations with religious belief and hesitations about xenotransplantation. Five thousand and eight individuals across the United States responded to the survey. The two biggest concerns about xenotransplantation across religious groups were the current …

The Integrative Genomic And Functional Immunological Analyses Of Colorectal Cancer Initiating Cells To Modulate Stemness Properties And The Susceptibility To Immune Responses., Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan, Sahar Da'as, Yosra Bejaoui, Nady El Hajj, Karama Makni Maalej, Said Dermime, Kakil Rasul, Paolo Dellabona, Giulia Casorati, Alice Turdo, Matilde Todaro, Giorgio Stassi, Soldano Ferrone, Xinhui Wang, Cristina Maccalli

Faculty Research 2025

BACKGROUND: Colorectal cancer (CRC) initiating cells (CICs) possess self-renewal capabilities and are pivotal in tumor recurrence and resistance to conventional therapies, including immunotherapy. The mechanisms underlying their interaction with immune cells remain unclear.

METHODS: We conducted a multi-omics analysis-encompassing DNA methylation, total RNA sequencing, and microRNAs (miRNAs; N = 800) profiling on primary CICs and differentiated tumor cell lines, including autologous pairs. Functional immunological assays were performed to assess the impact of miRNA modulation.

RESULTS: CICs exhibited distinct methylation patterns, transcriptomic profiles, and miRNA expressions compared to differentiated tumor cells (p < 0.05 or 0.01). Notably, miRNA-15a and -196a were implicated in regulating tumorigenic pathways, such as epithelial-to-mesenchymal transition (EMT), TGF-β signaling, and immune modulation. The transfection of CICs with miRNA mimics led to the downregulation of oncogenic EMT markers (CRKL, lncRNA SOX2-OT, JUNB, SMAD3) and TGF-β pathway, resulting in a significant reduction of the in vitro proliferation and the tumorigenicity and migration in a zebrafish xenograft model. Additionally, miRNA-15a enhanced the expression of antigen processing machinery and decreased the expression of immune checkpoints (PD-L1, PD-L2, CTLA-4) and immunosuppressive cytokines (IL-4). The co-culture of HLA-matched lymphocytes with CICs overexpressing the miRNA-15a, elicited robust tumor-specific immune responses, characterized by a shift toward central and effector memory T cell phenotypes and prevented their terminal differentiation and exhaustion. The combination of miRNA modulation with Indoleamine 2,3-dioxygenase blockade and immunomodulating agents further potentiated these effects.

CONCLUSIONS: Our study demonstrates that the modulation of miRNA-15a …

Student Senate Meeting Minutes February 17, 2025, Student Senate-Winona State University

Student Senate Meeting Minutes

This document is the official Winona State University Student Senate Minutes for February 17, 2025.

Woven Interpretations, R. Darden Bradshaw

Marian Library Blog Archive

The exhibit Warp & Weft: Weaving Mary and Identity was curated by the University of Dayton's Darden Bradshaw.

Small Molecule-Mediated Inhibition Of The Oxidoreductase Ero1a Restrains Aggressive Breast Cancer By Impairing Vegf And Pd-L1 In The Tumor Microenvironment, Ersilia Varone, Jaehyung Cho, Et Al.

2020-Current year OA Pubs

Cancer cells adapt to harsh environmental conditions by inducing the Unfolded Protein Response (UPR), of which ERO1A is a mediator. ERO1A aids protein folding by acting as a protein disulfide oxidase, and under cancer-related hypoxia conditions, it favors the folding of angiogenic VEGFA, leading tumor cells to thrive and spread. The upregulation of ERO1A in cancer cells, oppositely to the dispensability of ERO1A activity in healthy cells, renders ERO1A a perfect target for cancer therapy. Here, we report the upregulation of ERO1A in a cohort of aggressive triple-negative breast cancer (TNBC) patients in which ERO1A levels correlate with a higher …

Should Owners Of American Land Be . . . American? An Examination Of The Global Implications Of U.S. Agricultural Land Ownership And The Need For A Federal Regulation, Mattie Zepernick

LSU Journal of Energy Law and Resources

No abstract provided.

We Know About The Right To Bear Arms, But What About The Rights Of Bears Ears, Brandon Andrews

LSU Journal of Energy Law and Resources

No abstract provided.

The Case Against E-Waste In The Bayou State: Proposing E-Waste Recycling Legislation In Louisiana, Elizabeth Bueche

LSU Journal of Energy Law and Resources

No abstract provided.

America Runs On Biodiesel: Implementation Of A New Federal Mandate For Increased Renewable Energy Fuel, Asia Jackson

LSU Journal of Energy Law and Resources

No abstract provided.