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Massive Gastroduodenal Trichobezoar Removed With Hydrodissection: A Case Report, Seth Saylors, Cory Nonnemacher, Irene Isabel P. Lim

Manuscripts, Articles, Book Chapters and Other Papers

Introduction

Case presentation

Leveraging Artificial Intelligence And Machine Learning To Accelerate Discovery Of Disease-Modifying Therapies In Type 1 Diabetes., Melanie R. Shapiro, Erin M. Tallon, Matthew E. Brown, Amanda L. Posgai, Mark A. Clements, Todd M. Brusko

Manuscripts, Articles, Book Chapters and Other Papers

Progress in developing therapies for the maintenance of endogenous insulin secretion in, or the prevention of, type 1 diabetes has been hindered by limited animal models, the length and cost of clinical trials, difficulties in identifying individuals who will progress faster to a clinical diagnosis of type 1 diabetes, and heterogeneous clinical responses in intervention trials. Classic placebo-controlled intervention trials often include monotherapies, broad participant populations and extended follow-up periods focused on clinical endpoints. While this approach remains the 'gold standard' of clinical research, efforts are underway to implement new approaches harnessing the power of artificial intelligence and machine learning …

Integrative Analysis Of The 3d Genome And Epigenome In Mouse Embryonic Tissues, Miao Yu, Yang E Li, Et Al.

2020-Current year OA Pubs

While a rich set of putative cis-regulatory sequences involved in mouse fetal development have been annotated recently on the basis of chromatin accessibility and histone modification patterns, delineating their role in developmentally regulated gene expression continues to be challenging. To fill this gap, here we mapped chromatin contacts between gene promoters and distal sequences across the genome in seven mouse fetal tissues and across six developmental stages of the forebrain. We identified 248,620 long-range chromatin interactions centered at 14,138 protein-coding genes and characterized their tissue-to-tissue variations and developmental dynamics. Integrative analysis of the interactome with previous epigenome and transcriptome datasets …

Genomics Of Pediatric Cardiomyopathy, Teresa M Lee, Stephanie M Ware, Alicia M Kamsheh, Surbhi Bhatnagar, Mohammed Absi, Elyse Miller, Enkhsaikhan Purevjav, Kaitlin A Ryan, Jeffrey A Towbin, Steven E Lipshultz

2020-Current year OA Pubs

Cardiomyopathy in children is a leading cause of heart failure and cardiac transplantation. Disease-associated genetic variants play a significant role in the development of the different subtypes of disease. Genetic testing is increasingly being recognized as the standard of care for diagnosing this heterogeneous group of disorders, guiding management, providing prognostic information, and facilitating family-based risk stratification. The increase in clinical and research genetic testing within the field has led to new insights into this group of disorders. Mutations in genes encoding sarcomere, cytoskeletal, Z-disk, and sarcolemma proteins appear to play a major role in causing the overlapping clinical phenotypes …

Behavioural Realism And Its Impact On Virtual Reality Social Interactions Involving Self-Disclosure, Alan Fraser, Ross Hollett, Craig Speelman, Shane L. Rogers

Research outputs 2022 to 2026

This study investigates how the behavioural realism of avatars can enhance virtual reality (VR) social interactions involving self-disclosure. First, we review how factors such as trust, enjoyment, and nonverbal communication could be influenced by motion capture technology by enhancing behavioural realism. We also address a gap in the prior literature by comparing different motion capture systems and how these differences affect perceptions of realism, enjoyment, and eye contact. Specifically, this study compared two types of avatars: an iClone UNREAL avatar with full-body and facial motion capture and a Vive Sync avatar with limited motion capture for self-disclosure. Our participants rated …

Biophysical Response Of A Coastal Woodland To Extreme Water Deficit During A Year Of Record-Breaking Heat, Caitlin E. Moore, Sally E. Thompson, Jason Beringer, Wesley Cooper, Simone Gelsinari, Hoang Long Nguyen, Huanhuan Wang, Qiaoyun Xie, Richard P. Silberstein

Research outputs 2022 to 2026

Global terrestrial and ocean surface temperatures continue to reach record levels, resulting in heat waves, drought, and prolonged heat stress experienced by vegetation in many regions. In 2023-2024, coastal terrestrial ecosystems in Western Australia were particularly affected, experiencing their driest and hottest summer since observations began in the early 1900s. Banksia woodlands are a threatened ecological community in this region that are endangered by the cumulative impacts of climate change, clearing and changing groundwater regimes, the last of which is strongly influenced by the dual use of groundwater resources by the ecosystem and by the ∼2 million people in the …

Widespread Detection Of Second Generation Anticoagulant Rodenticides In Australian Native Marsupial Carnivores, Michael T. Lohr, Cheryl Anne Lohr, Judy Dunlop, Melissa Snape, Stephanie Pulsford, Evan Webb, Robert A. Davis

Research outputs 2022 to 2026

Anticoagulant rodenticides (ARs) have been detected in non-target wildlife species worldwide but information on exposure in Australian mammals is extremely limited. To address this, we analysed liver tissue from the five largest sized species of native Australian carnivorous and scavenging mammals for all SGARs currently used in Australia. A total of 52 individual animals from five dasyurid species were tested for exposure to ARs with 26 individuals (50 %) testing positive. Eleven individuals (21 %) tested positive for more than one AR compound, and two individuals tested positive for three types of AR. This study is the first to document …

Soundhapticsvr: Head-Based Spatial Haptic Feedback For Accessible Sounds In Virtual Reality For Deaf And Hard Of Hearing Users, Pratheep Kumar Chelladurai

Theses

Virtual Reality (VR) systems use immersive spatial audio that provide more localized sound awareness to convey critical information. However, these audio cues are often inaccessible to individuals who are Deaf or Hard-of-Hearing (DHH). To address this, we developed, a head-based haptic system designed to enable localizing and convert- ing audio signals directly into haptic feedback using multi-channel acoustic haptic actuators. We evaluated through three studies. The preliminary study determined the maximum tactile frequency threshold perceivable on different regions of the head of DHH users when a VR headset is attached. This was followed by a study to deter- mine the …

Relationships Between Brain Glucose Metabolism Patterns And Impaired Glycemic Status: A Systematic Review Of Fdg-Pet Studies With A Focus On Alzheimer's Disease, Setareh Soltani, Mahsa Dolatshahi, Sara Soltani, Kian Khazaei, Maryam Rahmani, Cyrus A Raji

2020-Current year OA Pubs

It is well-established that individuals with type 2 diabetes have an increased risk of developing cognitive impairment and Alzheimer's disease (AD). However, it is not fully determined how insulin resistance and type 2 diabetes are related to AD-related brain glucose metabolism abnormalities. For this aim, we performed a systematic review of the studies investigating the association between cerebral glucose metabolism and glycemic status, including diabetes, insulin resistance, or hyperglycemia. Medline, Embase, and Cochrane databases were searched (till February 2, 2025). All English full-text papers studying 18F-FDG-PET that investigated the association between cerebral FDG uptake or cerebral metabolism rate and glycemic …

Spatial Histomorphometry Reveals That Local Peripheral Nerves Modulate But Are Not Required For Skeletal Adaptation To Applied Load In Mice, Alec T Beeve, Mohamed G Hassan, Anna Li, Nicole Migotsky, Matthew J Silva, Erica L Scheller

2020-Current year OA Pubs

Mechanical loading is required for bone health and results in skeletal adaptation to optimize strength. Local nerve axons, particularly within the periosteum, may respond to load-induced biomechanical and biochemical cues. However, their role in the bone anabolic response remains controversial. We hypothesized that spatial alignment of periosteal nerves with sites of load-induced bone formation would clarify this relationship. To achieve this, we developed RadialQuant, a custom tool for spatial histomorphometry. Tibiae of control and neurectomized (sciatic/femoral nerve cut) pan-neuronal Baf53b-tdTomato reporter mice were loaded for 5 days. Bone formation and periosteal nerve axon density were then quantified simultaneously in non-decalcified …

Unraveling Algerian Bat Coronaviruses: From Initial Detection To Genome Recovery And Co-Infection Discovery, Safia Zeghbib, Zsófia Tauber, Tamás Görföl, Karimane Malek Zeghbib, Mourad Ahmim, Gábor Kemenesi

School of Biomedical Sciences

IntroductionBats, known as main reservoirs for coronaviruses such as SARS-CoV and SARS-CoV-2, carry these viruses asymptomatically thanks to their unique immune systems. These viruses can spill over to humans through direct contact or intermediate hosts, as observed in the cases of SARS and COVID-19. Despite the significant public health implications, research on bat-related viral zoonoses remains inadequate in Algeria due to insufficient surveillance and funding. Additionally, the ecological diversity of Algerian bats is still largely unexplored, resulting in knowledge gaps. Therefore, investigating bat coronaviruses within the One Health framework in Algeria provides a holistic approach to understanding and mitigating the …

Spatial Proteomics Of Onchocerca Volvulus With Pleomorphic Neoplasms Shows Local And Systemic Dysregulation Of Protein Expression, Lucia S. Di Maggio, Kerstin Fischer, Bruce A. Rosa, Devyn Yates, Byoung-Kyu Cho, Jessica Lukowski, Antonia Zamacona Calderon, Minsoo Son, Young Ah Goo, Nicholas O. Opoku, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer

2020-Current year OA Pubs

Onchocerca volvulus is the agent of onchocerciasis (river blindness) and targeted by WHO for elimination though mass drug administration with ivermectin. A small percentage of adult female worms develop pleomorphic neoplasms (PN) which occur more frequently after ivermectin treatment. Worms with PN have a lower life expectancy and improved understanding of proteins expressed in PN and their impact on different tissues could help elucidate the mechanisms of macrofilaricidal activity of ivermectin. Within paraffin embedded nodules removed after ivermectin treatment, we detected 24 (5.6%) O. volvulus females with PN. To assess the protein inventory of the PN and identify proteins potentially …

Rest And Rinse: Sleeping Rhythms Drive Brain Detox, Leon C D Smyth, Benjamin A Plog, Jonathan Kipnis

2020-Current year OA Pubs

Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.

Endothelial Cell Piezo1 Promotes Vascular Smooth Muscle Cell Differentiation On Large Arteries, Javier Abello, Ying Yin, Yonghui Zhao, Josh Maurer, Jihui Lee, Cherokee Bodell, Jahmiera Richee, Zarek Burton, Megan E Goeckel, Michelle Lin, Carmen M Halabi, Rajan Sah, Amber N Stratman, Et Al.

2020-Current year OA Pubs

Vascular stabilization is a mechanosensitive process, in part driven by blood flow. Here, we demonstrate the involvement of the mechanosensitive ion channel, Piezo1, in promoting arterial accumulation of vascular smooth muscle cells (vSMCs) during zebrafish development. Using a series of small molecule antagonists or agonists to temporally regulate Piezo1 activity, we identified a role for the Piezo1 channel in regulating klf2a, a blood flow responsive transcription factor, expression levels and altered targeting of vSMCs between arteries and veins. Increasing Piezo1 activity suppressed klf2a and increased vSMC association with the cardinal vein, while inhibition of Piezo1 activity increased klf2a levels and …

Contraceptive Hormone Influences On The Role Of Primary Reinforcement And Reinforcer-Enhancement In Nicotine Self-Administration, Kathleen Robin Mcnealy

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Hormonal contraceptives contain a synthetic estrogen (e.g., ethinyl estradiol/EE) and/or a synthetic progestin (e.g., levonorgestrel/LEVO) and can exacerbate nicotine intake. However, whether altered intake reflects changes in nicotine reinforcement or enhancement by nicotine of co-occurring reinforcers is unknown. This reinforcer-enhancement effect is evidenced in rats when nicotine self-administration is increased by the presence of a visual stimulus (VS) reinforcer. This dissertation examined the effects of EE and LEVO on nicotine reinforcement and reinforcer-enhancement in ovary-intact female Sprague-Dawley rats. Rats were implanted with a jugular catheter and assigned to receive daily injections of EE (Vehicle, 0.125 [Low], or 0.18 [High] μg/day; …

Space Crash, Tyler T. Le

Computer Science and Software Engineering

Space Crash is a game made using Unity Game Engine which utlizes a rollback netcode in order to handle online multiplayer. The purpose of such netcode is to predict user inputs accross the server in order to cause less delay between players who are playing through the network.

Insights From Consumers' Exposure To Environmental Nutrition Information On A Dashboard For Improving Sustainable Healthy Food Choices, Prince Agyemang, Ebenezer M. Kwofie, Jamie L. Baum, Dongyi Wang

Biological and Agricultural Engineering Faculty Publications and Presentations

Over the last decade, there has been a growing demand for tools to support sustainable healthy lifestyles, including food choices. Through a survey, this study examined the influence of environmental nutrition information conveyed with aids such as nudges and traffic light labels through a Dashboard for Improving Sustainable Healthy (DISH v1.0) food choices on consumer purchase intentions. DISH is an application that enables end-users to envisage and compare the potential impacts of their choices before purchasing. In the early stage of the technological development of DISH, the environmental nutrition information of two fast-food menus, plant-based and animal-based burgers, was tested …

News From Uab Libraries, 03 2025, Uab Libraries

UAB Libraries News

No abstract provided.

Identical Ratios: A Red Flag Of Ratio Management, Qianhua Ling, Andrea Alston Roberts

Accounting Faculty Research and Publications

This paper identifies a helpful red flag stakeholders can use to detect whether a nonprofit has managed its financial information. This red flag is reporting an identical program ratio—that is, the nonprofit organization reports the exact same ratio in multiple years—while reporting a large change in total spending. We find nonprofits are more likely to report identical program ratios when resource providers rely on ratios; pay is determined, at least in part, by performance; and the potential for regulatory interference is high. This paper also identifies the cost allocation techniques and the specific expenses nonprofits likely manage. We find most …

Protecting The Presumption Of Innocence: Tiktok Detectives, Misinformation And Private Content Moderation, Paige Sanders

Utah Law Review

The presumption of innocence is a fundamental component of the American legal system, but modern media platforms undermine its effectiveness. Platforms like TikTok have become popular sites for true crime content, allowing online detectives to spin their own narratives about high-profile crimes, often with little regard for the truth. This trend undermines the integrity of the legal system and causes irreversible harm to those being baselessly accused on social media. While TikTok and other social media platforms employ guidelines to moderate users’ content, they consistently fall short in preventing the spread of unverified true crime content. This Note explores TikTok’s …

Responses Of Skeletal Muscle To Mechanical Stimuli In Female Rats Following And During Muscle Disuse Atrophy, Alexander B. Sklivas, Zachary R. Hettinger, Sarah Rose, Alessandra Mantuano, Amy L. Confides, Sandra Rigsby, Frederick F. Peelor, Benjamin F. Miller, Timothy A. Butterfield, Esther E. Dupont-Versteegden

Physiology Faculty Publications

The purpose of this study was to investigate the ability of mechanotherapy to enhance recovery or prevent loss of muscle size with disuse in female rats. Female F344/BN rats were assigned to weight bearing (WB), hindlimb suspended (HS) for 14 days with reambulation for 7 days without mechanotherapy or reambulation (RA) with mechanotherapy (RAM) (study 1), or to WB, HS for 7 days, with HS mechanotherapy (HSM) or without mechanotherapy (study 2) to gastrocnemius muscle. Muscle fiber cross-sectional area (CSA) and fiber type, collagen, satellite cell number, and protein synthesis (k_syn) and degradation (k_deg) were assessed. …

Comparison Of The Use Of Therapeutic Plasma Exchange To Intravenous Immunoglobulin For Autoimmune Neurological Conditions At A Tertiary Hospital In Kenya., Swafiya Salim Busaidy

Master of Medicine in Internal Medicine

Background 

Plasma exchange (Barth et al.) and Intravenous Immunoglobulin (Barth et al.) have emerged as favored therapeutic options for autoimmune neurological conditions. Neurological conditions cause high morbidity and mortality in the sub-Saharan region. The utilization of these treatment options in Sub-Saharan Africa remains relatively unknown. We can determine the most efficient treatments with minimal cost implications by comparing the two treatment modalities in our setup.

Methods 

This retrospective descriptive chart review took place at Aga Khan University Hospital. It encompassed all patients admitted between 1st January 2011 and 31st December 2023 who had a neurological condition that necessitated treatment with …

Ubuntu In Namibia And Kenya: How Emerging Adults Live An Essential African Value Today, Julia S. Rotzinger, Lene Arnett Jensen, Amber Gayle Thalmayer

Psychology

Psychology in Africa often relies on Euro-American theories, despite their limitations in African cultures. Here, a shift to an Afrocentric perspective was made by exploring Ubuntu in two sub-Saharan African countries using a cultural-developmental psychology approach for in-depth emic understanding. Ubuntu (also known as botho, etc.) is a moral ideal that at core means placing a higher importance on the community than on oneself. Most literature on this important African concept has been theoretical rather than empirical, and little is known about how well it describes contemporary worldviews and experiences of emerging adults. In this interview study, Namibian and Kenyan …

Technology-Driven Education: Insights From Collegiate Esports, Rochell Mcwhorter, Julie Delello, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

This case study investigated how collegiate eSports players navigate the physical, mental, social, and academic challenges associated with competitive gaming, with a focus on its implications for adult education. Through in-depth interviews, the study explored players' diverse gaming routines, perceptions of excessive gaming, and strategies for balancing competing demands. While eSports participation fosters cognitive skills, social bonding, and career opportunities, it also presents risks such as physical inactivity, poor dietary habits, stress, and exposure to toxic gaming behaviors. A key finding is that the eleven students independently developed strategies to address these challenges, emphasizing the importance of integrating comprehensive support …

Prevalence Of Immunoglobulin E Sensitization To Various Inhaled Allergens Among The Residents Of The Northern United Arab Emirates: Automated Evaluation Of A Membrane-Based Test System, Israa O. Yousif, Nazeerullah Rahamathullah, Nelofar S. Khan, Mohammad Mesbahuzzaman, Mohammed Abdulrazzaq, Fawzia A. Alobeidli, Praveen K. Kandakurti

Saudi Medical Journal

Objectives: To determine specific positive immunoglobulin E (IgE) antibodies to various inhaled allergens in residents of Ajman and the northern region of the United Arab Emirates (UAE) using an automated evaluation of a membrane-based test. Methods: A total of 104 patients’ blood samples were received from various hospitals and clinics in Ajman and other northern Emirates regions at Thumbay Laboratory, Thumbay University Hospital, Ajman, UAE, to carry out inhalation allergy tests during the study period of 12 months (February 2023 until January 2024). Using the EUROLINE immunoblotting method, 20 different inhalation allergens-impregnated latex strips were used to carry out the …

Cannabis In The Clink: An Argument In Favor Of Medical Marijuana For Disabled Inmates, Sophia Dechurch

Journal of Law and Health

In recent decades, medical marijuana programs have become commonplace, and most states in the United States of America are ready to accept marijuana as a natural alternative to treat symptoms of certain conditions such as chronic pain, cancer, mental illness, multiple sclerosis (MS), HIV/AIDS, and substance use disorder; as such, medical marijuana is readily accessible to those who have a qualifying diagnosis – the exception being those who are incarcerated. Although disability, substance abuse, and mental illness are prevalent among those under state supervision, these individuals are effectively prohibited from enjoying the benefits of medical marijuana. This Note will provide …

Navigating Job Security In Turbulent Times: Challenges In The Entertainment, Airline, And Auto Industries, Joshua M. Javits

Hofstra Labor & Employment Law Journal

No abstract provided.

Accommodating Transportation To Work: How Courts Fail To Protect People With Disabilities By Inconsistently Interpreting The Ada’S Requirements To Provide Reasonable Accommodations To Employees, Tara Kniep

Marquette Benefits and Social Welfare Law Review

The Americans with Disabilities Act (ADA) has played a critical role in helping people with disabilities function with greater ease in an inaccessible world. However, it is not perfect and leaves many people without the accommodations they need. One of the many accommodations not directly and consistently protected by the ADA is transportation to and from work. While many Americans have enjoyed the work-from-home boom caused by the pandemic, there are many others that are forced to take remote jobs simply because they cannot secure safe and reliable transportation to and from work due to disability. This significantly narrows their …

Law, Music, Statutory Interpretation, And Schubert, Norman P. Ho

Hofstra Law Review

The law and humanities field has been dominated by law and literature. Legal scholars have, for example, analogized judges to literary authors and have tried to show how the study of literature and law can enrich both subjects. Law and music, however, has received relatively less attention. This Article argues, on its most macroscopic level, that the relationship between law and music is very close, just like the close relationship between law and literature. Previous scholarly literature in the law and music field has spoken about the affinities between law and music, but mostly on a general level and with …

Management Implications Of Human Livelihood Strategies On Madagascar's Coastal Landscapes, Katharine E.T. Thompson, Cortni Borgerson, Patricia C. Wright, Jeanne Mathilde Randriamanetsy, Niaina Nirina Mahefa Andriamavosoloarisoa, Mamy Yves Andrianantenaina, Théofrico Alexander Razafindrahasy, Ryan S. Rothman, Carter W. Daniels, Katherine J. Kling, Claire Surkis, Katheryn C. Twiss

Department of Anthropology Faculty Scholarship and Creative Works

The unsustainable harvest and consumption of wild animals destabilizes both wildlife populations and the human livelihoods that depend upon them. In coastal landscapes, the overexploitation of terrestrial resources can increase pressures on marine ecosystems, and vice versa. We explore populations' ability to mitigate hunting pressure by bolstering marine livelihood strategies, assessing whether Malagasy people (or aggregated households) (1) transfer harvest pressure and consumption from oceans to forests in times of lower fisheries yields and (2) habitually exploit both marine and terrestrial resources. We also evaluate the diversity of fishers' and hunters' methods used and species targeted, as reliance on a …