Digital Commons Network^™

Yap-Induced Glycolysis Drives Fibroinflammation And Disrupts Fibroblast Fidelity, Chang-Ru Tsai, Lin Liu, Yi Zhao, Jong H Kim, Paulo Czarnewski, Rich Gang Li, Fansen Meng, Mingjie Zheng, Jeffrey Steimle, Xiaolei Zhao, Francisco Grisanti, Zheng Sun, Jun Wang, Md Abul Hassan Samee, Xiao Li, James F Martin

Faculty, Staff and Students Publications

Background: Separation of the pulmonic and systemic circulation is essential for terrestrial life, and mammals have evolved distinct cardiac chambers with specialized structures and functions. Transcriptomics profiling revealed cellular heterogeneity between heart chambers. However, the mechanisms underlying chamber-specific transcriptomic and metabolic differences-and their functional significance-remain poorly understood. The Hippo/YAP (yes-associated protein) pathway is a conserved signaling network that regulates diverse cellular processes. The Hippo kinases inhibit YAP in cardiac fibroblasts (CF) to restrict fibrosis and inflammation. Nonetheless, how YAP regulates the metabolic microenvironment during homeostasis and fibroinflammation remains unclear.

Methods: We investigated YAP and glycolysis activity in the 4 cardiac …

A Mouse Model Of Lipoatrophy Reveals Relationships Between Beige Fat Appearance And Female Fertility, Elizabeth S Anaya, William Dion, Pradip K Saha, Aaron R Cox, Evelyn De Groot, Avery A Ahmed, Jessica B Felix, Bokai Zhu, Stephanie A Pangas, Sean M Hartig

Faculty, Staff and Students Publications

White adipose tissue (WAT) performs vital metabolic and endocrine functions, but roles in female reproduction remain understudied and poorly understood. Here, we report that female mice experiencing progressive lipoatrophy after knockout of Ubc9 in adipocytes (Ubc9fKO) displayed disrupted estrous cycles, reduced ovarian reserve, and subfertility. During aging, female Ubc9fKO mice lose subcutaneous WAT more quickly than their male counterparts and weigh less than littermate controls. Subcutaneous WAT excised from female Ubc9fKO mice strongly enriched for thermogenesis genes generally associated with metabolic benefits. Female Ubc9fKO mice exhibited hypermetabolism and accumulated thermogenic, Uncoupling Protein 1-expressing beige fat cells in residual subcutaneous WAT …

Extensions And Expansions Of Ubit, Levon C. Register

Tax Adviser

No abstract provided.

Create @ State 2011, Arkansas State University - Jonesboro

Create@State

The proceedings book for 2011

Restricted Word Order In Languages Without Overt Case Marking: Evidence From Modern Dialects Of Arabic, Mustafa Ahmed Al-Humari

UB Journal for Humanities

The study examines the morphosyntactic strategies used in Arabic language to indicate grammatical functions (subject, object) within a sentence, comparing and contrasting modern dialects of Arabic, particularly Saudi Arabic, and Yemeni Arabic, with Standard Arabic. The empirical observation of the study is that, while Standard Arabic mainly relies on a case marking strategy to determine grammatical functions, the modern dialects of Arabic under investigation are incapable of employing this strategy. This incapability raises questions about how grammatical functions are indicated in the absence of overt case morphology in the mentioned dialects. The paper argues that the absence of overt case …

The Quest For Connection In A Cold And Isolated World: A Psychoanalytical Study On Edward Albee's 'The Zoo Story', Abdulmajeed Abdulqadir Saeed Alhanash

UB Journal for Humanities

This research paper explores the theme of connection in a cold and isolated world through a psychoanalytical lens. It specifically focusses on Edward Albee's one-act play, The Zoo Story, examining how the characters' struggles with loneliness, alienation, and detachment reflect the broader human condition. It illuminates the underlying psychological motivations, anxieties, and desires that shape their actions and relationships. The psychological approach is used to analyze the social isolation and loneliness of characters in the play. Analyzing this theme psychologically illuminates the factors contributing to Jerry’s sense of isolation: lack of meaningful social connections, societal pressures, and personal experiences that …

Ibn Al-Bitar's Resources In The Comprehensive Book Of The Vocabulary Of Medicines And Foods: Collection And Study, Nasser Mohammed Alhazmi

UB Journal for Humanities

This study offers a comprehensive examination of the scientific sources used by the eminent Andalusian scholar Ibn al-Bayṭār in his monumental work “The Comprehensive Book on Simple Drugs and Foods.” The research aims to identify and analyze the references upon which Ibn al-Bayṭār built his material, highlight his methodological approach in quoting, comparing, and verifying earlier medical texts, and explore the scientific foundations of the botanical, animal-based, and mineral substances included in his encyclopedia. Ibn al-Bayṭār relied on more than 150 major sources, most notably the works of Dioscorides, Galen, and Hippocrates, in addition to the contributions of Muslim physicians …

Program Book 2025, Kari Harris

Arkansas Liberal Arts and Humanities Day

The program book for the inaugural Arkansas Liberal Arts and Humanities Day held on November 13th, 2025 in the Arkansas State Capitol building in Little Rock.

The Life And Legacy Of Sir Isaac Newton Told Through An Animated Short, Jediah L. Dillon

Arkansas Liberal Arts and Humanities Day

A 2-3-minute-long animated cartoon focusing on the life of Sir Isaac Newton. Focusing on topics like working on his mother's farm during his childhood, his hidden interest in physics and gravity before selling the idea to the public with the apple falling story, his teaching career, and his death.

Ecology Of Subaerial Algae: Photosynthetic Capacity As A Function Of Relative Humidity In A Naturally- Occurring Association, James A. Nienow

Georgia Journal of Science

Subaerial algae are defined by their ability to grow on surfaces exposed directly to the air. We are currently investigating the nature of the adaptations that allow these unicellular microorganisms to form rich growths in an environment subjected to repeated and prolonged periods without liquid water. It is well known from laboratory studies that at least some members of the group are able to sustain metabolic activity using water vapor at high relative humidity. However, data concerning the significance of this ability in natural populations are almost completely lacking. To help fill in this gap, we tracked the photosynthetic capacity …

Exculsivity Of Choice Of Court Agreements: Party Autonomy In Forum Selection, Mo Zhang

University of Memphis Law Review

Choice of court agreements are contractual agreements where parties exercise autonomy to agree on a forum to which the parties are voluntarily subject to should a dispute arise from their commercial transactions or other civil relationships. Exclusivity is an issue concerning how a choice of court agreement is to be enforced. Presumption of exclusivity is a doctrine aimed at ensuring an effective enforcement of the agreement as such. Acceptance of the doctrine has become a growing trend internationally, as illustrated by the 2005 Hague Convention on Choice of Court Agreements. In American courts, choice of court agreements are generally presumed …

Sexual Orientation, Rank, And Status, Duane Rudolph

University of Memphis Law Review

Dignity retains its ancient focus on rank and status. This Article, therefore, rejects the idea that we now live in the age of equal dignity, meaning equal rank and status for everyone. Rank underscores numbering, placement, and position in a predetermined hierarchy, and status underscores the power and privileges associated with each rank. Rank permits human beings to identify their preassigned location in the hierarchy, and status justifies assertions of rank since status governs the ancestral privileges, powers, and responsibilities attached to each rank. The Article relies on two constitutional cases, one before “dignity” and the other after. In 1986, …

The American Pantheon, Jadon Goldsmith

Philomathean

No abstract provided.

The Indiana Statesman, December 4, 2025, Indiana State University

Student Newspaper

Finals Week Schedule; The Pocket Galleries: one day only; Honors Students present research during Study Week

All Of Us Live In Texas, But Our Friends Hang Their Hats In New Zealand, Augusta Arata, Irene L. Flores, Angel Castillo, Robert Hoilman, Donald D. Sanders Ii

Sociology and Anthropology Student Research - Archive

Cultural similarities and differences between New Zealand and Texas through an anthropological perspective. The zine focuses on cuisine, sports, consumerism, and lifestyle choices.

Design With A Purpose: An Introductory Faith-Integrated Graphic Design Textbook For Christian Higher Education, Rosealine Lemette

Masters Theses

This thesis project addresses the absence of faith-informed graphic design curriculum available to Christian higher education programs creating a curricular gap that limits students’ ability to draw meaningful connections between their profession and Christian identity. The proposed solution in this project is an introductory graphic design textbook that combines foundational design theory, historical context, and hands-on skill building from a Christian worldview. This educational resource will guide students and faculty to view their profession as a divine calling, engaging in the creative process as an act of worship while developing an ethical and spiritually grounded design process. The comprehensive literature …

Protein-Protein Interaction–Interfering Peptide Rescues Dysregulated Nmda Receptor Signaling, Robert E. Featherstone, Hongbin Li, Ameet S. Sengar, Karin E. Borgmann-Winter, Olya Melnychenko, Lindsey M. Crown, Ray L. Gifford, Felix Amirfathi, Anamika Banerjee, Aivi Tran, Krishna Parekh, Margaret Heller, Wenyu Zhang, Robert J. Gallop, Adam D. Marc, Pragya Komal, Michael W. Salter, Steven J. Siegel, Chang-Gyu Hahn

Farber Institute for Neuroscience Faculty Papers

The complex and heterogeneous genetic architecture of neuropsychiatric illnesses compels us to look beyond individual risk genes for therapeutic strategies and target the interactive dynamics and convergence of their protein products. A mechanistic substrate for convergence of synaptic neuropsychiatric risk genes are protein-protein interactions (PPIs) in the N-methyl-D-aspartate receptor (NMDAR) complex. NMDAR hypofunction in schizophrenia is associated with hypoactivity of Src kinase, resulting from convergent alterations in PPIs of Src with its partners. Of these, the association of Src with PSD-95, which inhibits the activity of this kinase in the NMDAR complex, is known to be increased in schizophrenia. Here, …

Curriculum Subcommittee Agenda December 4, 2025, Utah State University

Educational Policies Committee

• Approval of Minutes - November 6, 2025
• R401 - Program Proposals
• Other Business
• Catalog Updates
• CIP Codes
• Adjourn 3:00 pm

Educational Policies Committee Minutes December 4, 2025, Utah State University

Educational Policies Committee

• Approval of Minutes - November 6, 2025
• Subcommittee Reports
• Center for Civic Excellence Updates
• Other Business
• Adjourn: 3:15 pm

Curriculum Subcommittee Minutes December 4, 2025, Utah State University

Educational Policies Committee

• Approval of Minutes - November 6, 2025
• Program Proposals
• Semester Course Approval Reviews
• Other Business
• Adjourn: 3:02 pm

Educational Policies Committee Agenda December 4, 2025, Utah State University

Educational Policies Committee

• Approval of Minutes - November 6, 2025
• Subcommittee Reports
• Other Business
• Adjourn: 4:00 pm

Improving Food Security: Determining Risk Zones For Toxic Crop Contamination, Parker J. Peterson, Cade Smith, Kirsten Sanders, Ruth Kerry, Sean Young

FHSS Mentored Research Conference

Aflatoxin contamination causes significant food waste and poses liver cancer risks to humans and livestock consuming infected corn. This study identifies high-risk years and locations in Texas by analyzing relationships between drought conditions, remote sensing data (NDVI and Thermal IR), and insurance claims for spoiled crops, enabling targeted interventions to reduce contamination and waste.

Spectator 2025-12-04, Editors Of The Spectator

The Spectator

No abstract provided.

Responding To The Association Of Secondhand Tobacco Smoke And Mental Illness: A Systematic Review, Pooja Bhattarai, Bassema Abu-Farsakh, Chizimuzo T.C. Okoli

Biennial Convention (CONV)

Background: Secondhand tobacco smoke (SHS) exposure represents a significant yet often overlooked public health challenge affecting over a billion people globally (World Health Organization 2021). Individuals exposed to SHS exposure inhale over 7,000 chemicals, including nicotine and other toxic substances, which adversely impact physical health (Carreras et al., 2019; Nadhiroh et al., 2020; U.S. Department of Health and Human Services, 2024). However, growing evidence suggests SHS exposure may increase the likelihood of poor mental health outcomes (Van der Eijk & Woh 2023, Zeng et al., 2016) Addressing SHS exposure not only requires acknowledging its impact but also respecting the …

The Clinical Pharmacogenetics Implementation Consortium's Consensus-Based Framework For Assigning Allele Function., Bailey M. Tibben, Andrea Gaedigk, Li Gong, Katrin Sangkuhl, Michelle Whirl-Carrillo, Mary V. Relling, Roseann S. Donnelly, Teri E. Klein, Kelly E. Caudle

Manuscripts, Articles, Book Chapters and Other Papers

The Clinical Pharmacogenetics Implementation Consortium (CPIC) is dedicated to integrating pharmacogenetic testing into clinical practice by developing and disseminating peer-reviewed, evidence-based gene-drug clinical practice guidelines. A critical component of this effort is the assignment of clinical function to pharmacogene alleles, which informs the translation of genetic test results into actionable prescribing decisions. This technology review outlines the standardized procedures and framework used by CPIC to assign allele clinical functional status through the work of Pharmacogene Curation Expert Panels (PCEPs). These panels, comprising multidisciplinary experts, systematically review and evaluate evidence to assign functional status to pharmacogenetic haplotypes. The process includes rigorous …

Wmu Board Of Trustee Board Meeting, Thursday December 4, 2025, Wmu Board Of Trustees

WMU Board of Trustees Meetings

• Acceptance of the Agenda
• Approval of the Minutes (October 30, 2025)
• Remarks by the Chair of the Board
• Remarks by the President
• Updates by the Faculty Senate President
• Updates by the Western Student Association President
• Updates by the Graduate Student Association President
• Presentation: The Voice of Bronco Success
• Public Comments Regarding Action Items

Action Items

Student Housing and Meal Rates 2026/27

Consent Items

Curriculum Proposals

Personnel Report

• General Public Comments

Raini Evergarden: Art399-Fa25 Portfolio Final, Raini Evergarden

Professional Practices (ART 399)

The value of an American worker has long since been measured in the value they provide in the enlargement of a billionaire’s wallet. Manipulated and oppressed by the system, American laborers have been reduced to shells of themselves, their sole purpose to keep the machine running. My work picks up the broken narrative and reflects the modern effects of violent American Capitalism on the working class.

Lithography and book arts are inherently anti-capitalist. The process and laborious nature of printmaking and bookbinding is inefficient, unruly, and full of failure. It resists the capitalist obsession with speed, productivity, and optimization. Through …

Discovery Of A Small Molecule Tlr3 Agonist Adjuvant, Branden Lee, Danica Dong, Etsuro Nanishi, John Mark Awad, Kimia Abedi, Yoshine Saito, Francesco Borriello, Soumik Barman, Byron Brook, Aisling Kelly, Manisha Menon, Constance Marques-Mourlet, Maansi Gupta, Ida Lister, Chiwoo Oh, Kevin Lyskawa, Morgan Goetz, Kristina Walker, Wing Ki Cheng, Spencer Brightman, Pankaj Sharma, Timothy O'Meara, Katherine Chew, Daniel Vieira, Kevin Ryff, Cali Sweitzer, Sanya Thomas, Simon Van Haren, Matthew Pettengill, Hyuk-Soo Seo, Sirano Dhe-Paganon, Wei Zhang, Ofer Levy, David Dowling

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Pattern-recognition receptor (PRR) agonists are valuable agents across multiple medical applications, from vaccinology to immune-oncology. However, well-defined and potent small molecule agonists for many PRRs still await discovery and development. Screening of chemical libraries of ~200,000 small molecules for maturation of human monocytic cells by quantifying NF-κB activation and cell adherence was completed. From this screen, we selected a thiazole benzamide derivative, PVP-057, for its robust immunomodulatory properties, low toxicity profile, and concentration-dependent activity. In vitro investigation of pathway and receptor activation reveals that PVP-057 is a Toll-like receptor 3 (TLR3) agonist. As a single-component adjuvant, administered intramuscularly or intradermally …

The Divided Self: Gothic Duality In Literature, Sarah Anna Meeks

Masters Theses

Gothic literature of the nineteenth century is haunting due to its frequent use of ghosts and monsters. However, the true terror lies in a deeper horror, one that is more intimate and destabilizing– a fright that leaps out of the text, looking into the heart of the reader: the fractured mind of the self torn between reality and repression, haunted by its own, newly manifested internal disunity rather than external monsters. The characters of Gothic fiction are typically caught in a psychological turmoil. They battle with split morals between duty and desire, morality and madness, and science and spirituality. Specifically, …

Primary Care Provider Communication Barriers With College-Aged Students, Mckenna Mahakian, Sharon Schaeffer, Rachel Immel

Honors Projects

As both a researcher and a college student, I’ve noticed that my peers and I share a common negative sentiment toward scheduling and attending routine doctor’s appointments. There are unique barriers in place for the age demographic; college students encountering the medical system and Primary Care Providers (PCPs) seem to have unique challenges in communication. I released a qualitative, anonymous survey to Bowling Green State University students to gauge opinionated responses on sentiments regarding how they felt about the level of communication between themselves and their provider, how the pediatric switch to a regular doctor impacted their inpatient care, how …