Digital Commons Network^™

Imaging Reactive Oxygen Species With L-012 Reveals Neutrophil Extracellular Trap Formation In Pancreatic Ductal Adenocarcinoma, Angisha Basnet, Kaitlyn M Landreth, Michael Sestito, Kristen Ranson, Seth T Gammon, David Piwnica-Worms, Brian A Boone, Tracy W Liu

Faculty, Staff and Student Publications

Neutrophils, key effector cells of the innate immune system, combat pathogens through mechanisms including the production of reactive oxygen species (ROS) and the release of neutrophil extracellular traps (NETs). While these responses are critical for host defense, prolonged elevation of ROS and dysregulated NETosis mediated by neutrophils have been implicated in autoimmune diseases, chronic inflammation, and cancer. In pancreatic ductal adenocarcinoma (PDAC), a highly aggressive and inflammatory malignancy, an increase in neutrophils infiltrating the tumor microenvironment promotes cancer progression and metastasis through increased ROS production and NET release. Using bioluminescence imaging with the reporter L-012 and NET assays, we assessed …

Collaborative Research: Verification Of Atmospheric Mercury Redox Reaction Rates, Colleen Patricia Jones

Funded Research Records

No abstract provided.

Investigating The Role Of Mitochondria In Postmortem Metabolism And Shelf Stability Of Fresh Meat, Sulaiman K. Matarneh, Kara J. Thornton-Kurth, Stephan Van Vliet

Funded Research Records

No abstract provided.

Performance Of The Iupod Intrauterine Device For Long-Term Fertility Control In Free-Roaming Mares, Chris Davies

Funded Research Records

No abstract provided.

Deep Learning For Underwater Manatee Counting And Tracking, Theodor Owchariw

Electronic Theses and Dissertations 2020 - Present

The Florida manatee (Trichechus manatus latirostris), a threatened marine mammal often found in coastal waters, require accurate monitoring to inform conservation strategies. However, traditional counting methods are hindered by observer bias and surface distortions. Recent advances in artificial intelligence (AI) address these challenges using captured aerial footage of manatees, demonstrating the potential of artificial intelligence for automating manatee counting. Still, various challenges arise hindering accurate counts.

Building on these studies, this work advances artificial intelligence with underwater footage, instance segmentation, data augmentation, and pseudo-labeling to automate manatee counting in data-scarce environments. Three experiments were conducted using 10%, 60%, and 90% …

155 Linden Llc V. Washington

All Decisions

In this nonpayment proceeding, the court granted the tenant's motion for leave to file an amended answer and for summary judgment. The landlord sought rent arrears for a Rent Stabilized apartment. The tenant argued that the landlord was barred from collecting rent due to open Department of Buildings (DOB) violations indicating occupancy contrary to the building's certificate of occupancy. Citing MDL §§ 301 and 302 and the controlling precedent of *Chazon, LLC v. Maugeneset*, the court found that the sixteen open DOB violations for unauthorized conversion of commercial space precluded the landlord from prosecuting the nonpayment action, regardless of whether …

Myocardial Lipin1 Protects The Heart Against Ischemic Injury By Preserving Lipid Homeostasis, Jiaxi Guo, Brian N. Finck, Et Al.

2020-Current year OA Pubs

Impaired cardiac lipid metabolism has been reported to cause heart failure. Lipin1, a multifunctional protein, is a phosphatidate phosphatase that generates diacylglycerol from phosphatidic acid and a transcriptional cofactor that regulates lipid metabolism-related gene expression. Here, we investigated the roles of lipin1 in cardiac remodeling after myocardial infarction (MI). The expression levels of lipin1 significantly decreased in cardiomyocytes of the human failing heart and murine ischemic myocardium. Cardiomyocyte-specific Lpin1 knockout (cKO) mice showed left ventricle enlargement and reduced fractional shortening after MI, compared with control mice. This was accompanied by elevated cardiac fibrosis, accumulation of reactive oxygen species, and increased …

Liver Injury In A Preclinical Model Of Short Bowel Syndrome Is Associated With Impaired Autophagy, Daniel M Alligood, Alex Park, Kerry Swanson, Naima Pyarali, Evan Mayse, David M Alvarado, Xiuli Liu, Jae-Sung Kim, Nicholas O Davidson, Deborah C Rubin, Jun Guo, Brad W Warner

2020-Current year OA Pubs

Critical for cellular maintenance and repair, autophagy recycles damaged or redundant cellular components. Dysregulated autophagy is associated with progressive cellular injury in various liver pathologies. However, the role of autophagy in intestinal failure-associated liver disease has not previously been investigated. Using a preclinical murine model of short bowel syndrome, we explored the role of autophagy impairment at early and late time points. Regardless of sex, small bowel resected (SBR) mice demonstrated significant liver injury compared to sham controls, exhibiting elevated serum transaminases, altered liver histology, and increased mRNA expression of endoplasmic reticulum stress marker (Ddit3) and oxidative stress marker (Nqo1). …

Library Guides For Graduate Students: A Content Analysis, Maria Kiriakova, Junli Diao, Joan Kelly Castro

Journal of Graduate Librarianship

This study looked at 117 Association of Research Libraries (ARL) academic library websites and identified 48 library guides that consider graduate students in general as their target audience. The broad and systematic content analysis of these library guides resulted in the discovery of four different types, which we categorized as Checklist, Orientation Module, Directory, and Comprehensive. We identify and describe content patterns that address the different roles graduate students might play as advanced library users, novice researchers, and teaching assistants/instructors. Academic librarians who have already created library guides for graduate students could use the results of …

Volume 23 - Front Matter

DePaul Business & Commercial Law Journal

No abstract provided.

Immeasurable Halls And Dreamlike Forms: Tracing The Caves Of Cheddar Gorge Throughout Tolkien’S Legendarium (And Beyond), Kristine Larsen

Journal of Tolkien Research

Cheddar Gorge (Mendip Hills, Somerset County, southwest England) is home to extensive cave systems carved into ancient limestone. Two of the most picturesque, Gough’s Cave and Cox’s Cave, are among the most important geological tourist attractions in England. Among the caves’ many enthusiasts was J.R.R. Tolkien, who first visited the site in 1916 while on his honeymoon and later in 1940 on a family vacation during his early work on The Lord of the Rings. As he noted in a 1971 letter these two visits (in particular, his earlier memories of the caves before their unfortunate commercialization) spawned the …

Tax Clinic, Paul Farber

Tax Adviser

No abstract provided.

The Tax Adviser, Volume 1, Number 5, May 1970, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Southern Adventist University Commencement Winter 2025, Southern Adventist University

Commencement Programs

Program for Southern Adventist University Winter 2025 graduation. The commencement service took place on December 18, 2025 at 7 pm in Iles Physical Education Center.

Arabic Around Us: Exploring Everyday Life Group Project, Bret Windhauser

Open Educational Resources

Students will work in small groups to create a comprehensive and engaging project that explores a particular aspect of everyday life in an Arabic-speaking country. This could include food, traditions, daily routines, or an introduction to the language itself. By the end of the assignment, students will demonstrate their understanding of Arabic vocabulary, grammar, and culture through a creative project.

French 123 Assignment: Group Project, Jovensel Ngamaleu

Open Educational Resources

This assignment is a way to engage with the real world through the practice of French in various areas of everyday life, in order to improve oral and written language skills.

Investigating Factors That Affect Total Ige Antibody Levels Of A Canine Population In Louisville, Ky, Iris N. Gillespie

Undergraduate Theses

Canine atopic dermatitis (CAD) is a genetically predisposed condition that causes inflammatory and pruritic (itchy) skin reactions in response to environmental and food allergens. The main purpose of this study is to determine if there is a correlation between pollen counts and total canine IgE antibody levels of dogs living in Louisville, KY. Additionally, data is analyzed to look for trends documented in previous studies related to the impacts of sex, age, and allergic symptoms on total IgE count. In collaboration with the Downtown Animal Hospital, blood samples were drawn from 16 dogs at one point in February (when pollen …

The Importance Of A Pressure Injury Prevention Program In Acute Hospital Settings, Sarah Orial

Student Scholarly Projects

Practice Problem: The identified practice problem for this project was the lack of a standardized pressure injury prevention program in a 350-bed acute care hospital. The lack of a standard program could be leading to increased hospital-acquired pressure injuries. PICOT: In adult inpatients in a medical/surgical unit (P), does the implementation of a standard unit-based pressure injury prevention program (I) compared to the current practice (C) increase the percentage of nursing skin risk assessment documentation (O) over a 10-week period (T)?

Evidence: The literature supports the development of standard pressure injury prevention programs and continuing education to …

Insm1 Governs A Neuronal Progenitor State That Drives Glioblastoma In A Human Stem Cell Model, Patrick A Desouza, Matthew Ishahak, Xuan Qu, Colin Mccornack, Devi Annamalai, Diane D Mao, Rajanikanth Vangipurapu, Yiwei Fu, Alexandre T Vessoni, Ryan T Cleary, Rowland H Han, Punn Augsornworawat, Timothy Woodiwiss, Darby Agovino, Braxton Sizemore, Jessica Kline, Maryam Borhani-Haghighi, Hao Chen, Sangami Pugazenthi, Hiroko Yano, Ting Wang, Luis F Z Batista, Jeffrey R Millman, Albert H Kim

2020-Current year OA Pubs

Glioblastoma is a lethal brain cancer marked by functional plasticity driven by tumor cell-intrinsic mutations and their interplay with developmental programs. To investigate how canonical glioblastoma mutations promote functional plasticity, we have developed an isogenic human neural stem cell (NSC) model of glioblastoma by sequential addition of TERT promoter, TP53, and PDGFRA point mutations. TP53 loss-of-function increases TERT expression during serial mutagenesis, but only triple mutant NSCs reliably form lethal brain tumors in vivo that recapitulate glioblastoma. Tumor cell evolution triggers stress-related metabolic changes and transitions toward a neuronal progenitor network driven by transcription factor INSM1. INSM1 is highly expressed …

Anticonvulsant Activity Of Simvastatin On Experimentally Induced Epileptic Seizures In Mice, Uday Abdul-Reda Hussein, Nargis Amer Nayef, Baneen Adel Abdul-Hussein, Tamara Hassan Mawazi, Zahraa Kadhim Hussein, Noor Alhuda Ali Saadon, Zainab Mohammed Abd, Fatima Mohammed Alwan, Huda Bassim Latif, Hassanein Mohammed , Razak, Mohammed Rida Majeed, Mohammed Abdul-Elah Abdul-Hamid

Al-Ameed Journal for Medical Research and Health Sciences

Background: Epilepsy is a common neurological disorder characterized by recurrent seizures. Simvastatin was recognized as a new candidate that exhibits a variety of neuroprotective effects, including antioxidant and anti-inflammatory effects that have the ability to inhibit neuronal hyperexcitability and seizure susceptibility.

Aim: The purpose of this study is to assess the possible anticonvulsant action of simvastatin in the mouse seizure model.

Material and Methods: The eighteen adult albino mice (25–30 g) were allotted randomly to three groups (n = 6). Thirty minutes before the induction of convulsion, the groups received different intraperitoneal pretreatments: Group 1: Distilled water (0.1 ml), Group …

Proteome-Wide Association Study Of Prostate Cancer Risk Across Populations, Hua Zhong, Jingjing Zhu, Shuai Liu, Chong Wu, Liang Wang, Seamus P. Whelton, Catherine H. Marshall, Michael J. Blaha, Peter Durda, Xiuqing Guo, Craig W. Johnson, Henry J. Lin, Kent D. Taylor, Russell P. Tracy, Ronit I. Yarden, Ani W. Manichaikul, Stephen S. Rich, Jerome I. Rotter, Rajat Deo, Ruth F. Dubin, Peter Ganz, Lang Wu

School of Graduate Studies Faculty Publications

There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be associated with PCa risk across populations. We develop genetic prediction models for expression of 1578, 1993, 1218, and 1390 proteins for African (n = 450), European (n = 758), Asian (n = 289), and Hispanic/Latino (n = 474) males, respectively, and evaluate associations of genetically regulated protein expression with PCa risk in 19,391 PCa cases and 61,608 controls of African population, 122,188 cases and 604,640 controls …

Elm: The Case Of Experiential Programming, Matthew Miller, Lynette Campogiani

Faculty and Staff Publications & Presentations

Experiential Programs (EPs) provide immersive, destination-focused experiences within luxury resort settings. However, research has yet to apply the elaboration likelihood model (ELM) to examine how guests evaluate their experiences with EPs, particularly within luxury tourism or resort contexts. Using the ELM framework, this study examined how the experience of luxury resort EPs influences guests’ revisit intentions. Guests’ experiences were categorized into central and peripheral processing cues and qualitative interview responses were analyzed. The findings indicate that elements such as ambient music and scenic views associated with peripheral processing had a significantly stronger positive impact on guests’ intentions to return than …

An Updated Annotated Checklist Of The Mammals Of The Crane Trust, Hall County, Nebraska, Bethany L. Ostrom, Amanda H. Medaries, Andrew J. Caven, Jenna M. Malzahn, Alexa Rojas, Matthew R. Schaaf, David M. Baasch, Thomas E. Labedz, Greg D. Wright

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

The Crane Trust is a regional nonprofit conservation organization that has protected land in the biologically important Central Platte River Valley for over four decades. A mammal inventory was conducted on the Crane Trust’s main habitat complex in 1980. Since, a variety of environmental conditions have shifted locally, regionally, and globally. An analysis of the mammal community was conducted using past and recent data to determine how species composition and relative abundance have shifted categorically from 1980 to 2021. We used all available data to categorize relative abundance during two distinct time periods per a modified “DAFOR” scale including 7 …

Evaluation Of Antibacterial Activity Of Amaranthus Spinosus Extract Against Streptococcus Mutans: An In-Vitro Study, Fakhrun Nisa, Juen Carla Warella, Valentine Hursepuny, Johan Bruyif Bension, Khairunnida Rahma

Folia Medica Indonesiana

Streptococcus mutans is a component of the normal oral flora that can become a primary pathogen, leading to dental caries and tooth decay. Tooth decay and dental caries are the most common oral health issues worldwide. Treatment of dental caries and tooth decay represents a crucial effort in addressing global health concerns. One alternative treatment the community used to treat dental caries and tooth decay is thorn spinach (Amaranthus spinosus). Thorn spinach leaves contain bioactive compounds with potential antibacterial properties, including flavonoids, tannins, saponins, and alkaloids. This study aimed to evaluate the antibacterial activity of thorn spinach leaf …

Double Burden Stress In Women And The Role Of Psycho-Religious Worship In Alleviating It, Fahmi Mandala Putra, Zata Ismah, Rizky Indah Syahfitri, Citra Cahyati Nasution, Az-Zahra Atika Putri, Fitria Amirah, Tri Amelia Rahmitha Helmi

Folia Medica Indonesiana

It has been recognized that women are twice as likely to experience depression compared to men. In addition to biological vulnerability, there is also a combined effect of bearing the burden of household responsibilities while contributing financially through employment. One coping strategy that helps women endure these challenges is meditation, which in Islam includes the practice of dhikr (remembrance of God). This study aims to analyze the phenomenon of double burden stress in women and how psychoreligious practices can help reduce stress levels. The study employed a prospective cohort design, tracking the respondents' dhikr habits over a 21-day period. On …

Actin Dysregulation Induces Neuroendocrine Plasticity And Immune Evasion: A Vulnerability Of Small Cell Lung Cancer, Yoojeong Seo, Shengzhe Zhang, Jinho Jang, Kyung-Pil Ko, Kee-Beom Kim, Yuanjian Huang, Dong-Wook Kim, Bongjun Kim, Gengyi Zou, Jie Zhang, Sohee Jun, Wonhong Chu, Nicole A Kirk, Ye Eun Hwang, Young Ho Ban, Shilpa S Dhar, Joseph M Chan, Min Gyu Lee, Charles M Rudin, Kwon-Sik Park, Jae-Il Park

Faculty, Staff and Student Publications

Small cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. Capping protein inhibiting regulator of actin dynamics (CRACD) that promotes actin polymerization, is frequently inactivated in SCLC. However, the role of CRACD loss in SCLC is unknown. Here we show that CRACD depletion drives neuroendocrine (NE) cell plasticity and immune evasion in SCLC. Mechanistically, CRACD inactivation disrupts actin organization, leading to suppression of Yap1-NOTCH signaling and subsequent NE gene upregulation. Simultaneously, CRACD loss drives EZH2-mediated histone methylation via nuclear actin disruption, leading to repression of MHC-I genes and depletion of CD8⁺ T cells. Consequently, CRACD-downregulated tumors exhibit …

Sex Hormones Influence Ormdl3 Expression: Implications For Sex-Associated Asthma Phenotype, Elisabetta Granato, Ida Cerqua, Antonietta Rossi, Maria Antonietta Riemma, Maria Chiara Monti, Giusy Ferraro, Barbara Romano, Maria Francesca Nanì, Danilo D'Avino, Martina Simonelli, Joshua Malo, Francesca Polverino, Bruno D'Agostino, Giuseppe Cirino, Fiorentina Roviezzo

Faculty, Staff and Students Publications

Background: Genetic polymorphisms in sphingolipid metabolism, particularly involving the orosomucoid-like 3 (ORMDL3) gene, have been associated with asthma risk. Notably, asthma prevalence and severity exhibit pronounced sex differences, emerging in childhood and persisting into adulthood. However, the molecular mechanisms underlying this sexual dimorphism remain incompletely elucidated.

Objective: We investigated whether ORMDL3 contributes to sex differences in airway function and asthma-like features.

Methods: ORMDL3 expression was measured in lung tissues from healthy male and female human donors and in human bronchial epithelial cells (BEAS-2B) after exposure to 17β-estradiol (E2), Dermatophagoides pteronyssinus 1 (Der p 1), or both. A murine preparation of …

Islamic Prophetic Counseling: An Intervention Strategy In Developing Students' Noble Character, Hardi Santosa, Ahmad Zaki Annafiri, Iin Inawati, Akhmad Fajar Prasetya, Muhammad Sabri Bin Sahrir

Buletin Konseling Inovatif

This study aims to test the effectiveness of Islamic prophetic counseling in developing students' noble morals. The research method uses a true experiment involving a control group. The selection of the control group uses the waiting-list control group model, with consideration of the ethical aspects of the study. The research sample involved 244 students captured the profile of noble morals and their spiritual activism. While the hypothesis test involved 50 students who were divided into control and experimental groups. The sample selection was carried out randomly with the random assignment technique. The research data were collected using a noble moral …

Private Foundations And Tax Reform: Composition And Concepts, William J. Lehrfeld

Tax Adviser

No abstract provided.

A Distance Based Embedding Method Using Nlp Methods To Identify Proximity To A Network, Shuhan Zhang, Anurag Tangri, Chinmay Narendra Sonar, Lin Meng, Can Liu, Chiranjeet Chetia

Defensive Publications Series

The present disclosure relates to the field of Artificial Intelligence (AI), in particular to AI methods and systems for analyzing transactional data using Natural Language Processing (NLP) techniques to identify latent relationships and proximity within networks. The disclosed system utilizes text fields within datasets to categorize input data into appropriate classifications. The input comprises a dataset containing text data that provides contextual information related to transactions. Feature embeddings are generated using a sentence-based Language Learning Model (LLM), which captures semantic meaning of sentences. The LLM converts input data of varying lengths into fixed-dimension embeddings. The sentence-based LLM is fine-tuned based …