Digital Commons Network^™

Model-Based Vision System For Evaluation And Improvement Of Gaits In Legged Locomotion, Kenneth P. Clark, Christopher R. Meng, Laurence J. Ryan

Defensive Publications Series

This disclosure relates to the evaluation and improvement of gaits in legged locomotion of humans, animals, and robots by superimposing a biomechanical figure selected from a spectrum of models onto the recorded motion of a test subject. For gait evaluation, a model is selected from a database to closely match the observed gait and existing performance parameters are obtained. For gait improvement, an incrementally superior model is selected from the database to provide enhanced performance goals. This Model Vision Evaluation (MoVE) system thus includes spectrums of biomechanical models over a range of inferior to superior levels of skill and performance …

Autonomous Causal Inference Using Artificial Intelligence Agents, Teginder Singh, Ramakrishnan Neelakandan, Bakul Patel, Justin Chen, Kiran Dattani, Sean Hamill, Jacob Van Bochove

Defensive Publications Series

Post-market drug-safety procedures, known as pharmacovigilance, require a team of skilled physicians or epidemiologists to manually investigate each adverse event. This disclosure describes artificial intelligence (AI) agent-based, cloud computing techniques that automate the end-to-end cognitive workflow of investigating potential adverse drug events (ADEs). Moving beyond current techniques, which only perform statistical signal detection, the described techniques enable the determination of biological causality. Upon receiving a statistical signal of an adverse event, plausible biological hypotheses that can explain the signal are autonomously generated. A set of specialized software agents are dispatched to forage for evidence across disparate data sources (real-world evidence …

Effect Of Ovarian Characteristics And Propylene Glycol Supplementation On Pregnancy Rates Per Ai In Suckled Beef Cows Subjected To A 7-Day Co-Synch Fixed-Time Ai Protocol Across Seasons, Body Condition Scores, And Postpartum Intervals, Pachara Pearodwong, Sarawanee Khunmanee, Kajohn Nitiwararuk, Thuwanon Boonkerd, Thananon Junsuri, Andrew A. Ponter, Winai Kaewlamun

The Thai Journal of Veterinary Medicine

The present study evaluated the independent effects of ovarian characteristics and oral propylene glycol (PG) supplementation on pregnancy rates in suckled beef cows subjected to the 7-day CO-Synch + CIDR fixed-time AI (FTAI) protocol across different seasons, body condition scores (BCS; 5-point scale), and parturition-to-FTAI intervals. Cows received a CIDR insert and 10 μg GnRH on day -10, followed by 25 mg PGF2α at CIDR removal on day -3, and another 10 μg GnRH 72 h later (day 0). In Study 1, the ovarian characteristics of 36 cows were assessed transrectally on days -10 and 0 relative to the FTAI. …

Temperature Predicts Myotis Lucifugus Declines And Persistence After White-Nose Syndrome Introduction, Tanner M. Barnes, Jared D. Wolfe, Allen Kurta, Steve M. Smith, John E. Depue

Michigan Tech Research Data

No abstract provided.

Interview With Orca Award Winner John J. Janovy, Jr., Unl Biological Sciences; Parasitologist And Author, Mark Griep, John J. Janovy Jr.

UNL ORCA Interview Series

Professor John Janovy, Jr., was awarded the ORCA in 1998. John was born in Louisiana, but his family moved to Oklahoma, where he grew up in Tulsa and then Oklahoma City. Something in his youth must have sparked an interest in science because he earned three degrees from the University of Oklahoma in Norman: a bachelor of science in math in 1959, a master of science in zoology in 1962, and doctoral degree in zoology in 1965. Next, he ventured 1400 miles east to Rutgers University in New Brunswick, New Jersey, where he did post-doctoral work for about a year. …

Elevated Lactate In Aml Bone Marrow Contributes To Macrophage Polarization Via Gpr81 Signaling., Celia A Soto, Maggie L Lesch, Jennifer L Becker, Azmeer Sharipol, Amal Khan, Xenia L Schafer, Zhewen Li, Amanda R Streeter, Michael W Becker, Joshua C Munger, Benjamin J Frisch

Oncology Articles

Interactions between acute myeloid leukemia (AML) and the bone marrow microenvironment (BMME) are critical to leukemia progression and chemoresistance. In the solid tumor microenvironment, altered metabolite levels contribute to cancer progression. We performed a metabolomic analysis of AML patient bone marrow serum, revealing increased metabolites compared to age- and sex-matched controls. The most highly elevated metabolite in the AML BMME was lactate. Lactate signaling in solid tumors induces immunosuppressive tumor-associated macrophages and correlates with poor prognosis. This has not yet been studied in the leukemic BMME. Herein, we describe the role of lactate in the polarization of leukemia-associated macrophages (LAMs). …

Analytical Assessment Of Pedestrian Crashes On Low-Speed Corridors, Therezia Matongo, Deo Chimba

Civil and Architectural Engineering Faculty Research

This study presents a comprehensive statewide analysis of pedestrian-involved crashes recorded in Tennessee between 2002 and 2025. We evaluated the influence of roadway, traffic, environmental, and socioeconomic factors on pedestrian crash frequency and severity with substantial components focused on lighting impacts including dark and nighttime. A multi-method analytical framework was implemented, combining descriptive statistics, non-parametric tests, regression analysis, and advanced machine learning techniques including the Adaptive Neuro-Fuzzy Inference System (ANFIS) and the gradient boosting model (XGBoost). Results indicated that dark and nighttime conditions accounted for a disproportionate share of severe crashes—fatal and serious injuries under dark conditions reached over 40%, …

From The Margins To The Center: The Transformative Promise Of Philosophy For Children, Maughn Rollins Gregory, Megan Jane Laverty, Joe Oyler

Department of Educational Foundations Scholarship and Creative Works

What began as an innovative idea in the late 1960s—the recognition that even very young children are philosophically disposed—is no longer considered novel. While philosophy for children has transitioned from a fledgling initiative to a worldwide movement, it remains on the margins of education. In this article, we look back at key initiatives that have advanced its growth before looking ahead to what can move philosophy for children to the center of education. We consider the introduction and development of materials that invite children into philosophical spaces, the community of philosophical inquiry as a model of teachers' and children's philosophical …

The Breakdown Of Neurovascular Barriers: Molecular Mechanisms Of Tight Junction Dysfunction, Sowmya Shree Gopal, Mandeep Kaur, Sophie Lanzkron, Amit K. Srivastava

Department of Medicine Faculty Papers

The central nervous system (CNS) relies on tightly regulated barriers to maintain homeostasis and protect neural tissue from blood-borne toxins, pathogens, and inflammatory mediators. Tight junctions (TJs) are critical components of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), forming selective paracellular seals that regulate molecular trafficking. These structures comprise transmembrane proteins and cytoplasmic scaffolding proteins, which anchor TJs to the actin cytoskeleton. The spatial organization and function of TJs are dynamically regulated by calcium-dependent signaling, phosphorylation events, and G-protein-mediated pathways, which govern their assembly, disassembly, and response to physiological and pathological stimuli. The integrity of TJ complexes is …

Consensus-Based Expert Recommendations For Diagnosis And Clinical Management Of Vanishing White Matter., Romy J. Van Voorst, Daphne H. Schoenmakers, Joshua L. Bonkowsky, Adeline Vanderver, Ingeborg Krägeloh-Mann, Geneviève Bernard, Enrico Bertini, Ali Fatemi, Paulo V. Sgobbi, Nicole I. Wolf, Samuel Groeschel, Davide Tonduti, Caroline Sevin, Jennifer L. Orthmann-Murphy, Ludger Schöls, Ettore Salsano, Bernard Brais, Nicole Jaffe, Kasper W. Ter Horst, Sabine E. Hannema, Katherine G. Hayes, Jochen Meyburg, Marc Van Heerde, Anne Marie Sbrocchi, Rosalina Van Spaendonk, Isabelle Thiffault, Geesje H. Hofsteenge, Carolina Sudmeier-Broek, Corrie Timmer, Donna Skwirut, Allyson Buck, Bret Hollberg, Ron Chapleau, Hanka Dekker, Susan G. Campbell, Truus E M Abbink, Prisca S. Leferink, Marjo S. Van Der Knaap

Manuscripts, Articles, Book Chapters and Other Papers

Vanishing white matter (VWM) is a rare disorder, characterized by degeneration of CNS white matter, clinically often exacerbated by stressors such as fever and minor head trauma. VWM is caused by biallelic pathogenic variants in the EIF2B1-5 genes, causing reduced activity of eukaryotic initiation of translation factor 2B, resulting in dysregulation of the integrated stress response (ISR). New scientific insights and increased clinical trials in experimental therapies highlight the need for clinical guidelines to improve and standardize care for patients with VWM worldwide. Standardized care is important for therapy development, as it lessens clinical variability of trial participants at study …

In Silico Approach Of Flavonol In Hibiscus Sabdariffa As Proteasome Inhibitors Targeting The Ubiquitin-Proteasome Pathway, Nur Amalia Choironi, Syakhsiyatunnisa Galuh Prameswari, Hanif Nasiatul Baroroh

Chimica et Natura Acta

Multiple myeloma is a blood cancer characterized by the abnormal proliferation of B cells that accumulate in the bone marrow. The proliferation of these cells depends on the role of the proteasome through the ubiquitin-proteasome pathway to degrade proteins that regulate the cell cycle, apoptosis, and stress response. The proteasome is the main target of proteasome inhibitors for the treatment of multiple myeloma. Flavonoid compounds in Hibiscus sabdariffa flowers, such as isoquercitrin, quercitrin, quercetagetin, isorhamnetin, and astragalin, have the potential to act as proteasome inhibitors. The insilico study aims to determine the potential of these compounds as proteasome inhibitors based …

Disrupting Cell Death: Ferroptosis And Pyroptosis Inhibition In Hepatic Ischemia-Reperfusion Injury Via Modulation Of Gpx4 And Cgas Pathways By Deferoxamine And Octreotide,, Rasha A. Tawfiq, Yasmeen Attia, Hameis M. Sleem, Mai Ghoneim Dr.

Pharmacy

Hepatic ischemia-reperfusion injury (HIRI) is a significant complication of liver transplantation, often precipitating postoperative liver dysfunction/failure. Given the rising global prevalence of end-stage liver disease, which necessitates liver transplantation, protecting against HIRI is crucial. Here, we investigated the effects of octreotide (OCT), a pyroptosis inhibitor, and deferoxamine (DEF), a ferroptosis suppressor, individually and combined in the HIRI model. Their impact on cyclic GMP-AMP synthase/stimulator-of-interferon (cGAS/STING) genes and glutathione peroxidase 4 (GPX4) activity was explored. Male rats (n = 4–5) were subjected to 30 min ischemia followed by 3 h reperfusion and treated with OCT (75 μg/kg; 30 μg/kg, i.p. & …

Advancing Louisiana's Cropping Systems: Sustainable Bioenergy Production, Cover Crops, And Technology Integration, Pedro R. Carrillo

LSU Doctoral Dissertations

The adoption of cover crops in Louisiana is lower than the national average, underscoring the need for region-specific research to address environmental challenges and demonstrate the short-term benefits of these practices within existing production systems. This research evaluated the integration of cover crops (CC) in energy cane (Saccharum spp.) and no-till cotton systems, focusing on their effects on soil health, nitrogen (N) management, and biomass production. Soil health indicators (SHIs), including enzymatic activities (β-glucosidase, β-glucosaminidase, and urease), protein N, inorganic N concentrations (nitrate and ammonium), soil organic matter (SOM), and microbial community composition assessed through ester-linked fatty acid …

Dairy And Food Science Student Newsletter, December 9, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.

Electrochemical Sensors For In Situ Monitoring Of Reactive Species During Cold Atmospheric Plasma-Based Therapies, Jonathan Thomas, Suneel Kumar, Gagana Karkada, Julia Sutter, Kristina Pattison, Jason Rainone, Dhruv Patel, Shashank Madhavan, Fred Krebs, Francois Berthiaume, Vandana Miller, Katharina Stapelmann

Kimmel Cancer Center Faculty Papers

Cold atmospheric pressure plasma (CAP) is emerging as a clinically relevant therapy for dermatological conditions such as actinic keratosis, warts, and chronic wounds. However, these therapies lack strategies to monitor CAP delivery in situ and to ensure delivery of an effective CAP dose without unwanted toxicity. CAP acts as a therapeutic agent in these biomedical applications primarily (but not solely) through reactive oxygen and nitrogen species (RONS) generated at transiently high local concentrations. Here we demonstrate the use of bio-electrochemical sensors capable of real-time measurements of key CAP RONS: hydrogen peroxide and oxidation-reduction-potential (ORP). In in vitro scratch assays and …

Communities With Diverse Subsistence Needs Require A Variety Of Functional Tree Traits, Minoseheno Rakotovao, Cortni Borgerson, Kerry A. Brown, Joris P. G. M. Cromsigt, Steig E. Johnson, Onja H. Razafindratsima, Ruth Mendum, Onjaniaina O. Andrianjatovo, Harisoa B. Ravaomanalina, Seheno Andriantsaralaza, Sheila M. Holmes

Department of Anthropology Faculty Scholarship and Creative Works

Tree species preference is an understudied yet crucial component of sustainable forest management, as unsustainable harvesting can lead to non-random loss of functional traits. We examine wood resource preference across five regions of Madagascar's biodiverse eastern humid forests. We asked forest users in 19 men's and 19 women's focus groups to list their preferred tree species for common short- (charcoal, firewood) and long-term (house construction, furniture, tools) uses. We then measured functional traits of 260 preferred and common tree species: height, DBH, bark thickness, specific leaf area, wood specific gravity, and seed dispersal syndrome in the surrounding landscape. Using household …

Orbital Reliable Printed Circuit Boards, Thomas Maxwell Starnes, Keegan Blake Jordan, Ian Griffith, Grant Monroe Pesqueira, Vishal Navin Patel

Senior Design Project For Engineers

Deep Interstellar Solutions is proposing a device to produce custom, serviceable printed circuit boards (PCBs) in low Earth orbit. This technology uses blank PCBs that are laser-etched and prepared for electrical components, then stored in the module. This method of PCB production allows for rapid repairs or prototyping without the need for subsequent resupply missions. By implementing this technique, future missions will achieve greater autonomy, sustainability, and resource efficiency. The goal of this development is to pioneer the creation of custom circuitry for use in deep-space missions where resupply is neither cost-effective nor timely.

In Their Own Voice: A Grounded Theory On Overcoming Internet Gaming Disorder, Jayson Carmona

Theses and Dissertations

Internet Gaming Disorder (IGD) is highly comorbid with depression, anxiety, sleep loss, lower productivity, and social isolation. The DSM-5 TR designates IGD as a condition for further study, however the ICD-11 has designed Gaming Disorder as a codified illness. While most studies look at IGD via a medical model lens focusing almost exclusively on symptomology, very little research explores the process of recovery in IGD. In this grounded theory inquiry, a theory of recovery from IGD is generated. Secondary internet data consisted of 113 posts on the subreddit /r/StopGaming on reddit.com. This resulted in 196 pages of data. Researcher used …

The Need To Incorporate Polysubstance Use In Neuropsychopharmacology Research: Biological Lessons And New Opportunities, Max E. Joffe, Susan M. Ferguson, Nick W. Gilpin, Melissa A. Herman, Lori A. Knackstedt, Patrick A. Randall, Abigail G. Schindler, Mary M. Torregrossa, Jennifer A. Rinker

School of Medicine Faculty Publications

Critical evaluation and refinement of animal models is essential for neuroscientists to understand complex physiological and pathological processes related to psychiatric diseases. In general, preclinical studies modeling drug dependence and problematic substance use have been limited to the administration of a single substance; however, there is a growing appreciation that this approach has failed to capture the complexities of humans and has stifled translational efforts. Polysubstance use represents the overwhelmingly common patterns of alcohol and drug use in humans. For example, epidemiological studies generally determine that between 70–95 % of individuals with alcohol use disorder use tobacco daily, and upwards …

Network Pharmacology Of Ki Encok (Plumbago Zeylanica Linn) Plant As A Treatment For Osteoarthritis, Mitayani Purwoko, Trisnawati Mundijo, Yoshiko Widyadi

Chimica et Natura Acta

One of the plants in Indonesia used by the community to treat gout or Osteoarthritis (OA) is the Ki Encok plant (Plumbago zeylanica Linn). However, it is currently unknown what active substances play a role in the therapy process for gout or OA and what the pathway is. This study aimed to predict the pharmacological mechanism of the active content of Encok leaves against OA disease. This study used an in silico experimental test. The content of active plant substances was extracted from IMPPAT and KNAPSACK. Then, the target proteins of all these active substances were searched for, including target …

The Scandal Of The Incarnation, Donald Roth

Faculty Work Comprehensive List

"Humanity has always longed for a connection to something higher. Most religions offer some way to transcend the physical, and Christians have often shared that longing."

Posting about ­­­­­­­­the incarnation of Christ from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

The Scandal of the Incarnation

An Exploratory Evaluation Of The Kalamazoo River Watershed Council: Assessing Organizational Impact And Value, Alexander Mendez

Honors Theses

The Kalamazoo River Watershed Council (KRWC) plays a central role in protecting, restoring, and promoting the long-term health of the Kalamazoo River watershed, a geographically expansive and ecologically complex system facing persistent challenges from legacy contamination, nonpoint source pollution, land-use pressures, and inequitable access to watershed resources. This honors thesis presents an exploratory organizational evaluation of the KRWC, assessing its role and relevance within the watershed, the effectiveness of its programs and partnerships, the strengths and limitations of its governance structure, and opportunities to strengthen its long-term sustainability and impact.

Guided by principles of Practical Participatory Evaluation (PP-E) and Fourth …

A Review Of Bioactive Compounds Of Caesalpinia Sappan: Pre- And Post-Harvest Effect, Annisa Lugina Rachman, Santi Rosniawaty, Syariful Mubarok, Cucu Suherman, Yudithia Maxiselly

Jurnal Kultivasi

Sappanwood (Caesalpinia sappan L.) is a shrub or small tree that thrives in tropical regions and has been widely distributed across various areas. It has long been used as a natural dye in textiles, cosmetics, and herbal beverages due to its content of various bioactive compounds. This literature review discusses the secondary metabolites in sappanwood, their health benefits, and strategies to enhance product quality through pre-harvest and post-harvest treatments. This literature review was conducted by searching for relevant journals on Google Scholar using relevant keywords. Sappanwood contains diverse secondary metabolites, including flavonoids, phenolics, anthraquinones, triterpenoids, steroids, alkaloids, and tannins, with …

To Jump Or Not To Jump: Comparing Effects Of Phenotypic Plasticity On The Visual Responses And Escape Behavior Of Locusts And Grasshoppers, Soumi Mitra, Saina Namazifard, David Mario Bellini, Alexis Leigh Sarne, Bidisha Halder, Margaret Ruth Eisenbrandt, Aliya Macknojia, Jiayi Luo, Samme Xie, Hojun Song, Chenghang Zong, Fabrizio Gabbiani, Richard Burkett Dewell

Faculty, Staff and Students Publications

Locusts exhibit remarkable phenotypic plasticity changing their appearance and behavior from solitary to gregarious when population density increases. These changes include morphological differences in the size and shape of brain regions, but little is known about plasticity within individual neurons and alterations in behavior not directly related to aggregation or swarming. We investigated looming escape behavior and the properties of a well-studied collision-detection neuron in gregarious and solitarious animals of three closely related species, the desert locust (Schistocerca gregaria), the Central American locust (S. piceifrons) and the American bird grasshopper (S. americana). For this neuron, the lobula giant movement detector …

Tgfbr2 Coordinates The Endometrial Response To Estrogen, Regulating Endometrial Hyperplasia And Fertility, Sydney E Parks, Suni Tang, Anna Catherine Unser, Ananya L Bhonsley, Eunbi M Chung, Peixin Jiang, Audrey Savolainen, Vanessa J Joseph, Dominique I Cope, Ramya P Masand, Renata Prunskaite-Hyyryläinen, Diana Monsivais

Faculty, Staff and Students Publications

Proper endometrial function is critical for establishing and maintaining healthy pregnancies, as well as preventing the pathogenesis of conditions such as endometrial hyperplasia and endometrial cancer. The TGFβ signaling pathway regulates key aspects of endometrial biology, although the direct effects of many individual receptors remain unstudied. In this study, we characterize the role of TGFβR2 within the endometrium using a progesterone receptor-cre conditional knock-out mouse model (Tgfbr2flox/flox;Pgrcre/+; “Tgfbr2 cKO”). We found that conditional deletion of TGFβR2 resulted in female infertility, endometrial hyperplasia, altered estrogen and progesterone response, and, only in bred females, reproductive tract …

Rare Epigenetic Alterations Are Conserved Across Hematopoietic Differentiation Stages After Mycobacterial Infection, Brandon T Tran, Pamela N Luna, Ruoqiong Cao, Duy T Le, Apoorva Thatavarty, Laure Maneix, Bailee N Kain, Scott Koh, Andre Catic, Katherine Y King

Faculty, Staff and Students Publications

Infection leads to durable cell-autonomous changes in hematopoietic stem and progenitor cells (HSPCs), resulting in production of innate immune cells with heightened immunity. The mechanisms underlying this phenomenon, termed central trained immunity, remain poorly understood. We hypothesized that infection induces histone modifications leading to changes in chromatin accessibility that are conserved during differentiation from HSPCs to myeloid progenitors and monocytes. We conducted genome-wide surveillance of histone marks H3K27ac and H3K4me3 and chromatin accessibility in hematopoietic stem cells, multipotent progenitor 3, granulocyte-monocyte progenitors, monocytes and macrophages of naïve and Mycobacterium avium infected mice. Interferon signaling pathways and related transcription factor binding …

Glycoside Hydrolase-Mediated Glucomannan Catabolism In Segatella Copri, A Target Of Microbiota-Directed Foods For Malnourished Children, Cyrus Zhou, Matthew C Hibberd, Evan M Lee, Suzanne Henrissat, Marie A Crane, Jiye Cheng, Michael J Barratt, Jeffrey I Gordon, Et Al.

2020-Current year OA Pubs

Evidence is emerging that perturbed postnatal gut microbiota development is causally related to childhood undernutrition. Clinical trials in undernourished Bangladeshi children found that a polysaccharide-rich, microbiota-directed complementary food (MDCF-2) designed to repair this perturbation produced superior ponderal and linear growth compared to a standard ready-to-use supplementary food. Subsequent analyses disclosed several candidate bioactive polysaccharides in the MDCF and their bacterial targets, notably strains of

Avant-Garde Architectural Influences In Japanese Cinema: The Influences Of Kenzo Tange And Archigram, Aissatou L. Balde, Ehsan Sheikholharam Ma

Symposium of Student Scholars

Kenzo Tange and Metabolists created a blueprint for utopian and organic urban futures in postwar Japan, inspiring the fictional worlds of Japanese cinema and animation, from Akira’s cyber-punk cityscapes to Howl’s Moving Castle’s urban mobility. These futuristic cities have a lot in common with Archigram in their “Walking City” concept. While Metabolists focused on cities that could grow and change like living organisms, Archigram took it further by designing robot-like megastructures that could walk across the planet. Neither group built most of their ideas, but both used imaginative designs to rethink how cities could work in a fast-changing world. These …

Tax Trends, Harry Z. Garian

Tax Adviser

No abstract provided.

Prophet, Stephen D. Kelly

Valparaiso Fiction Review

No abstract provided.