Antimicrobial Susceptibility Trends In E. Coli Causing Pediatric Urinary Tract Infections In The United States, Simren Mahajan, Neena Kanwar, Gina M. Morgan, Rodrigo E. Mendes, Brian R. Lee, Dithi Banerjee, Rangaraj Selvarangan

Manuscripts, Articles, Book Chapters and Other Papers

Urinary tract infections (UTIs) are among the most common pediatric infections. This study evaluated the antimicrobial susceptibility patterns of 3511 uropathogenic E. coli (UPEC) isolated from pediatric patients in the United States from 2014 to 2023. The database from the SENTRY antimicrobial surveillance program from 89 medical centers was utilized as a data source. The antimicrobial susceptibility was tested using the microbroth dilution technique against 24 antimicrobial agents. MICs were determined using the CLSI/EUCAST/FDA breakpoint criteria. All the antimicrobials reported susceptibility rates above 80% except for tetracycline (76.2%), trimethoprim-sulfamethoxazole (69.7%), and ampicillin-sulbactam (55.7%). During the study period, the susceptibility rates …

Mutation- And Mrd-Informed Treatments For Transplant-Ineligible Patients, Curtis A Lachowiez, Courtney D Dinardo

Faculty, Staff and Student Publications

The ongoing development of molecularly targeted therapies in addition to the new standard of care combination of azacitidine and venetoclax (AZA-VEN) has transformed the prognostic outlook for older, transplant-ineligible patients with acute myeloid leukemia (AML). While conventional treatments, such as standard anthracycline and cytarabine- based chemotherapy or hypomethylating agent (HMA) monotherapy, are associated with a generally poor prognosis in this patient population, the use of these novel regimens can result in long-lasting, durable remissions in select patient subgroups. Furthermore, the simultaneous discovery of resistance mechanisms to targeted therapies and AZA-VEN has enabled the identification of patient subgroups with inferior outcomes, …

Piloting A Zero-Emission Delivery Zone In Downtown Portland, Art Pearce, Sarah Pullman, Jacob Sherman

PSU Transportation Seminars

The Portland Bureau of Transportation (PBOT) was awarded a nearly $2 million Strengthening Mobility and Revolutionizing Transportation (SMART) Grant by the US Department of Transportation (USDOT) in Fall 2023 to pilot the country’s first regulated Zero-Emission Delivery Zone in downtown Portland and test digital infrastructure tools. This project will test an innovative set of incentives and regulations to better understand what technology and strategies municipalities can use to support and reduce greenhouse gas emissions in the freight sector.

While other cities in the United States have piloted voluntary Zero-Emission Delivery Zones (ZEDZs) to encourage the transition of commercial fleets to …

Biophysical Adaptations Of Collective Cell Migration Through Multiscale Obstructions And Collagen Fibers In Extracellular Matrices, Ye Lim Lee

McKelvey School of Engineering Graduate Student Theses & Dissertations

Collective cell migration is a multiscale process, regulated by mechanosensitive proteins, adhesions between cells and with the extracellular matrix (ECM), and force propagation across length scales. The collective cell migration occurs as the cells receive the mechanical stimuli from the extracellular matrix and respond by generating forces to migrate. This behavior is widely observed in biological processes such as wound repair, angiogenesis, and pathogenic events like cancer metastasis and adipose tissue dysfunction. In these processes, cells often encounter heterogeneous topologies that disrupt and alter collective migration, yet it remains unclear how changes in matrix topology affect migration speed and cell-cell …

A Mathematical Model For Malaria Transmission Dynamics In The Population With Different Immune Status, Neema S. Mbugi, Jacob I. Irunde, Joshua A. Mwasunda, Samson Kiware

Tanzania Journal of Science

Malaria is a febrile illness affecting a large population worldwide. Even though malaria is curable and preventable it continues to pose a significant health risk, economic effects, and social effects in the population. This study formulates a mathematical model to study the transmission dynamics of malaria in a population with different immune status. By dividing the population based on immune status, the model provides insights into how immunity influences the interaction between hosts and malaria parasites, particularly in terms of infection rates, immune responses, and propose appropriate control for effective elimination. The basic reproduction number is computed using the next-generation …

Bio-Interventional Cyclodialysis And Allograft Scleral Reinforcement For Uveoscleral Outflow Enhancement In Open-Angle Glaucoma Patients: One-Year Clinical Outcomes, Tsontcho Ianchulev, Robert N Weinreb, Ernesto A Calvo, James Lewis, Gautam Kamthan, Arsham Sheybani, Douglas J Rhee, Iqbal K Ahmed

2020-Current year OA Pubs

BACKGROUND: To evaluate the one-year safety and effectiveness of bio-interventional cyclodialysis and scleral reinforcement in open-angle glaucoma (OAG) patients undergoing cataract surgery.

METHODS: An ab-interno approach was used to create a sectoral cyclodialysis in OAG patients who were prospectively followed in a consecutive case series. Subsequent visco-cycloplasty with scleral reinforcement using homologous minimally modified allograft scaffold was completed to maintain patency of the cyclodialysis reservoir and increase uveoscleral outflow. Outcomes were mean medicated IOP and mean number of IOP-lowering medications. Safety outcomes were adverse events (AEs) and best-corrected visual acuity (BCVA) changes.

RESULTS: Successful cyclodialysis and allograft bio-scaffold reinforcement was …

Kinetics And Oligomer Products Of The Multiphase Reactions Of Hydroxyacetone With Atmospheric Amines, Ammonium Sulfate, And Cloud Processing, David O. De Haan, Leila Nahid Hawkins, Elyse A. Pennington, Hannah G. Walsh, Alyssa A. Rodriguez, Michael A. Symons, Alyssa D. Andretta, Michael A. Rafla, Chen Le, Audrey C. De Haan, Tianqu Cui, Jason D. Surratt, Mathieu Cazaunau, Edouard Pangui, Jean-François Doussin

Chemistry and Biochemistry: Faculty Scholarship

Hydroxyacetone (HA) is an atmospheric oxidation product of isoprene and other organic precursors that can form brown carbon (BrC). Measured bulk aqueous-phase reaction rates of HA with ammonium sulfate, methylamine, and glycine suggest that these reactions cannot compete with aqueous-phase hydroxyl radical oxidation. In cloud chamber photooxidation experiments with either gaseous or particulate HA in the presence of the same N-containing species, BrC formation was minor, with similar mass absorption coefficients at 365 nm (<0.05 m2 g–1). However, rapid changes observed in aerosol volume and gas-phase species concentrations suggest that the lack of BrC was not due to slow reactivity. Filter-based UHPLC/(+)ESI-HR-QTOFMS analysis revealed that the SOA became heavily oligomerized, with average molecular masses of ∼400 amu in all cases. Oligomers contained, on average, 3.9 HA, 1.5 ammonia, and 1.6 other small aldehydes, including, in descending order of abundance, acetaldehyde, glycolaldehyde, glyoxal, and methylglyoxal. PTR-ToF-MS confirmed the production of these aldehydes. We identify C17H26O5, C10H22O9, C15H27NO7, C17H23NO5, and C18H32N2O9 as potential tracer ions for HA oligomers. We hypothesize that efficient oligomerization without substantial BrC production is due to negligible N-heterocycle (e.g., imidazoles/pyrazines) formation. While HA photooxidation is unlikely a significant atmospheric BrC source, it may contribute significantly to aqueous SOA formation.

2024-2025 Performance Forum - December 6, 2024, Jose Ignacio Diaz, Anna Dunford, Christian Bartholomew, Steven Halpner, Jeremiah Grace, Megan Hagel, Sheng Yuan Kuan, Youbeen Cho, Hoon Chang, Rishi Gurnani, Keegan Neely, Baran Zolfaghari, Ruzanna Usmanova, Elizaveta Goryunova, Gabrielle Malaniak

Performance Forum

No abstract provided.

The Effect Of Seed Provenance And Organic Fertilizer Types On Growth And Yield Of G2 Potato (Solanum Tuberosum L. Cv. Medians) Seeds In Jatinangor Medium Plains, Mohammad Faisal Rafiif, Wawan Sutari, Jajang Sauman Hamdani

Jurnal Kultivasi

Potato growth is influenced by seed provenance and fertilization, but the availability of high-quality potato seeds is still limited. To overcome those challenges, solutions include using temperature-tolerant potato varieties from medium plains and applying organic fertilizers to improve potato growth and yield. The purpose of this research was to determine the effect of the interaction between seed provenance and application of organic fertilizers on the growth and yield of G2 potato seeds of the Medians cultivar in the Jatinangor medium plains. The research was conducted from June to October 2023 at the Ciparanje Experimental Farm, Faculty of Agriculture, Universitas Padjadjaran, …

What Patients And Caregivers Want To Know When Consenting To The Use Of Digital Behavioral Markers, Anika Sonig, Christine Deeney, Meghan E Hurley, Eric A Storch, John Herrington, Gabriel Lázaro-Muñoz, Casey J Zampella, Birkan Tunc, Julia Parish-Morris, Jenny Blumenthal-Barby, Kristin Kostick-Quenet

Center for Medical Ethics and Health Policy Staff Publications

Artificial intelligence (AI)-based computational tools for deriving digital behavioral markers are increasingly able to automatically detect clinically relevant patterns in mood and behavior through algorithmic analysis of continuously and passively collected data. The integration of these technologies into clinical care is imminent, most notably in clinical psychology and psychiatry but also other disciplines (e.g., cardiology, neurology, neurosurgery, pain management). Meanwhile, ethical guidelines for implementation are lacking, as are insights into what patients and caregivers want and need to know about these technologies to ensure acceptability and informed consent. In this work, we present qualitative findings from interviews with 40 adolescent …

The Effectiveness Of Risk Management In Project Success, Vishwa Goswami

Harrisburg University Dissertations and Theses

Abstract: This study investigated the effectiveness of risk management on project success within agile software development environments. It addressed the increasing complexity and challenges that agile teams faced in managing risks, which, if unmitigated, could significantly hinder project outcomes relate to time, cost, quality, and stakeholder satisfaction. By examining the intersection of risk management practices with agile methodologies, the research identified critical gaps and proposed tailored solutions to enhance overall project success. The study emphasized the importance of incorporating risk management into project planning and execution, thereby increasing the likelihood of successful project outcomes. It analyzed the effects of organizational …

Comparative Study Of Rice Morphological And Physiological Characteristics Of Rice Grown Under Organic And Inorganic Farming, Amad Safrudin, Ratna Dewi, Dulbari

Jurnal Kultivasi

Organic farming practices have shown a potential to improve rice yields, aside from the popular conventional ones. This study aimed to comparatively analyze the morpho-physiological characteristics of rice plants grown under organic and inorganic farming. This research was conducted at the Polinela Organic Farm experimental station (5°21'10"S 105°13'43"E, 114 m sea above level), from February to April 2023 using a completely randomized design. The results showed that rice grown organically exhibited a notably higher chlorophyll index and actual water use efficiency compared to those grown inorganically. Conversely, inorganic farming resulted in a greater number of tillers than organic farming. However, …

Maize Hybrids’ Genetic Variability Based On Qualitative And Quantitative Traits, Slamet Bambang Priyanto, Herawati, Suwarti, Ayyub Ar Rahman, Nining Nurini Andayani, Abdul Fattah, Muhammad Azrai

Jurnal Kultivasi

Genetic variability was a prerequisite to doing a plant breeding program. A broad genetic variability allows plant breeders to select a desired genotype. This research aims to assess the maize hybrid's genetic variability based on qualitative and quantitative traits. This research was conducted in the Bone district, south Sulawesi, from November 2022 to March 2023. Fifteen maize hybrids were arranged in a randomized complete block design with three replications. The variables observed are qualitative and quantitative traits. Principal component (PCA) and cluster analyses assessed the genetic variability. The result indicated that based on a loading factor greater than 0.70, the …

Spino-Plastic Surgery: Addressing Spinal Tumors With New Techniques, Casey Martinez, Isra Abdulwadood, Sebastian Winocour, Alexander E Ropper, Marco Innocenti, Michael Bohl, Maziyar Kalani, Edward M Reece

Faculty, Staff and Students Publications

Background/Objectives: Spino-plastic surgery describes a specialized, multidisciplinary approach to addressing various spinal pathologies. The field is the innovative product of a multidisciplinary collaboration between plastic and reconstructive, orthopedic, and neurosurgery. Over the last few decades, this collaboration has borne promising surgical techniques and treatment plans geared toward restoring form, function, and aesthetics in patients with a variety of spinal conditions, including failed fusions, pseudoarthrosis, and the need for oncologic reconstruction. This paper explores the application of spino-plastic surgery in the context of post-sarcoma resection reconstructions, focusing on the efficacy in addressing the unique challenges posed by extensive tissue loss and …

Transplant-Associated Tma: The Conundrum Of Diagnosis And Treatment, Ang Li, Sarah E Sartain

Faculty, Staff and Students Publications

Transplant-associated thrombotic microangiopathy (TA-TMA) after hematopoietic cell transplantation is characterized by microangiopathic hemolytic anemia (MAHA) with persistent schistocytosis, elevated markers of hemolysis, thrombocytopenia, and microvascular thrombosis leading to ischemic injuries in the kidneys and other organs. The initial evaluation of the disease requires confirmation of non-immune MAHA and careful examination of known secondary causes of TMA. Due to increased likelihood of long-term renal failure and overall mortality, a rapid diagnosis and treatment of the underlying trigger is needed. However, the diagnostic criteria proposed to define TA-TMA remain insufficient. sC5b9, the soluble form of the membrane attack complex of the terminal …

Domain-Specific Representation Of Social Inference By Neurons In The Human Amygdala And Hippocampus, Runnan Cao, Julien Dubois, Adam N Mamelak, Ralph Adolphs, Shuo Wang, Ueli Rutishauser

2020-Current year OA Pubs

Inferring the intentions and emotions of others from behavior is crucial for social cognition. While neuroimaging studies have identified brain regions involved in social inference, it remains unknown whether performing social inference is an abstract computation that generalizes across different stimulus categories or is specific to certain stimulus domain. We recorded single-neuron activity from the medial temporal lobe (MTL) and the medial frontal cortex (MFC) in neurosurgical patients performing different types of inferences from images of faces, hands, and natural scenes. Our findings indicate distinct neuron populations in both regions encoding inference type for social (faces, hands) and nonsocial (scenes) …

Sirtuins As Key Regulators In Pancreatic Cancer: Insights Into Signaling Mechanisms And Therapeutic Implications, Surbhi Chouhan, Anil Kumar, Naoshad Muhammad, Darksha Usmani, Tabish H Khan

2020-Current year OA Pubs

Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal cancers, marked by rapid progression, pronounced chemoresistance, and a complex network of genetic and epigenetic dysregulation. Within this challenging context, sirtuins, NAD

Develop Secure Software Specifications For Android App Concealing The Information And Safeguarding Data, Huda Abdulaali Abdulbaqi, Ahmmad Mohamad Ghandour, Thekrayat Abbas Jawad

Iraqi Journal for Computer Science and Mathematics

In the current landscape of technological advancement, data holds a pivotal role, shaping societal interactions and daily routines. The rapid escalation in digital data volume, driven by technological strides, has underscored the critical necessity for robust protective measures to safeguard its sensitive nature. This study aims to develop a secure software specification for Android application ensuring effective data protection through a specialized Android application tailored explicitly for data concealment, assuring utmost confidentiality and secure transmission. In this paper we revolve around the integration of multifaceted security and privacy protocols, employing advanced information concealment techniques, encryption mechanisms, secure key management, and …

Smart Switch To Embedded Speaker, Hp Inc

Defensive Publications Series

This disclosure is to improve the user experience for switching audio device. With the sensing function of discrete amplifier and speaker, users can tap the speaker location to let the audio signal come out from speaker.

Improved Process For Preparation Of Substituted Pyrazolo [3,4-B] Pyridine, Anonymous

Defensive Publications Series

The present publication relates to process for preparation of substituted pyrazolo [3,4- b] pyridine of Formula (I) which is an important intermediate in the preparation of soluble guanylate cyclase (sGC) stimulator.

Support Structure And Glue Pattern For Improving Camera Module Impact Resistance, Bin Su, Wu Cheng Shiun

Defensive Publications Series

Over time, as mobile devices and smartphones are designed to be thinner (and/or shorter), their cameras become vulnerable to separation from the chassis and to breakage. Cameras can be susceptible to failure if the device is dropped, and camera components break. This disclosure describes a holder for the infra-red cut filter (IRCF) of a camera that is of superior strength and impact resistance. The IRCF holder can be made of plastic or similar material with a bottom support, buffering material, and shaped glue. The bottom of the IRCF holder is ribbed to provide greater resistance to bending deformation. Glue-filled grooves …

Compressible Thermally Conductive Foam Cold Plate, Na

Defensive Publications Series

Conventional cold plate designs that utilize skived or machined fins face performance and design limitations due to constraints in fin thickness, pitch, and material choice. This disclosure describes a cold plate design that utilizes compressible thermally conductive foam or alternative three-dimensional (3D) conductive structures in place of traditional fins. The foam is constructed from materials such as copper, carbon, or graphene, and can enhance heat dissipation by offering increased surface area and variable density across the coolant flow path. The design allows precise thermal control by matching foam materials to the cooling needs to specific chip regions and can achieve …

Quantum And Bio-Inspired Self-Healing Networks, Na

Defensive Publications Series

This disclosure describes techniques to reduce the costs and inefficiencies associated with providing redundancy in networks by using self-healing network architectures. The techniques feature quantum-inspired routing algorithms (QIRA) and bio-inspired self-healing (BISHA). QIRA leverages quantum principles to concurrently explore multiple paths and to share information about network conditions through quantum entanglement. BISHA leverages cellular automata to mediate inter-device communication, such that when a failure is detected, the device is isolated and information about the failure is communicated to neighboring devices. The neighboring devices collaborate to reconfigure the network topology and reroute data traffic around the failed component. Machine learning algorithms, …

Integrated Circuit Emulation Based On Scan Mode Signal Flow, Na

Defensive Publications Series

This disclosure describes optimized emulation of integrated circuits (ICs) based on migration of information from scan test signal flows (DFT signals). Per techniques of this disclosure, DFT signal flows such as scan mode signals and scan clocks are automatically migrated to emulation signal flows and tied off during emulation such that they are excluded during emulation of the IC. Tie-off of DFT signals can enable faster emulation as well as relieve capacity constraints on the emulation platform. In some implementations, automatic scripts may be utilized to generate emulation code based on the functional tests to be performed and the DFT …

Improved Process For Preparation Of The Intermediate Of Androgen Receptor Inhibitors, Anonymous

Defensive Publications Series

The present publication relates to process for preparation of 2-fluoro-4-nitro benzoic acid which is an important intermediate in the preparation of androgen receptor inhibitors of general Formula I

Data-Driven Design For Thermal Management And Control In Datacenters, Na

Defensive Publications Series

Design of thermal controllers for datacenter machines has traditionally relied on heuristics and trial-and-error testing, resulting in lengthy design times and possibly suboptimal controller parameters. This disclosure describes techniques that leverage control and linear-system theory to build models that enable the software simulation of thermal controllers used in datacenters. Per the techniques, test data is captured from a real machine and used to create a reduced-order model of the machine and its thermal controller. A transfer function of the reduced-order model is obtained using linear system theory. Control theory is leveraged to determine the appropriate controller parameters for the machine …

An Improved Process For Preparation Of Vonoprazan Or Its Acid Addition Salt., Anonymous

Defensive Publications Series

The present publication relates to process for preparation of Vonoprazan of Formula I or its acid addition salt thereof.

Garcinia Pedunculata Roxb. Ex Buch.-Ham. Leaf Extract Ameliorates Diabetes In Streptozotocin Induced Diabetes In Rats, Kangkan Kalita, Techi Gello, Nilutpal Sharma Bora, Zothan Puia

Bulletin of Faculty of Pharmacy Cairo University

Although medicinal plants have been historically used for diabetes treatment throughout the world, few of them have been validated by scientific criteria. Diabetes mellitus is a metabolic disorder manifests as elevated blood glucose levels when the body cannot create sufficient amounts of insulin or utilize the insulin produced. This may be due to the free radicals present in the body. The antioxidants help to neutralize the free radicals by donating electron and thus protect from various oxidative stress diseases. The aim of this work is to evaluate the preliminary phytochemical screening, in vitro antioxidant study, in vitro and in vivo …

Outside The Dichotomy: Redefining Judith As A Prophet, Heidyn Von Bose

Studia Antiqua

The character of Judith has often been reduced to a dichotomy: is she a pro-feminist or an anti-feminist character? This traditional debate limits Judith and tries to squeeze her into ill-fitting literary boxes. The fol- lowing paper offers a more nuanced interpretation for the character and role of Judith within her story, particularly that Judith is a prophet. It first dem- onstrates that she meets the criteria of a prophet by synthesizing the works of Martti Nissinen, Esther Hamori, and Lester L. Grabbe. It then examines how her “irritations”—morally or culturally questionable actions—do not disqualify her from this role. The …

Joshua As A Hymn Of Glory: An Analysis And Comparison Of Ancient Near Eastern Texts, Richard D. Jarvis Iii

Studia Antiqua

A knowledgeable reader of the Hebrew Bible understands that there are two conflicting conquest narratives contained in the books of Joshua and Judges. This paper seeks to reframe Joshua 5–11 in a genre other than the traditional interpretation of a conquest narrative. These chapters of Joshua, as compared with Merneptah’s Victory Stele and the annals of Adad-Nārārī II, fit thematically into an entirely different genre from ancient Near Eastern literature: hymns of glory. Using four char- acteristics inspired by the work of Susan Hollis—propagandistic royal ideology, divine empowerment or call, utter destruction of enemies, and will of the deity accomplished—to …