Digital Commons Network^™

Clyde Pontefract V. Bop

2024 Decisions

USDC for the District of New Jersey

Studies Of Media To Maximize The Expression Of Bacterial Metalloprotease Genes As Potential Therapeutics For Human Alzheimer’S Disease, Uday Kiran Chigurupati

Honors Capstones

This study investigates the potential of bacterial metalloprotease genes as therapeutic agents for Alzheimer's Disease (AD). The research focuses on Pseudomonas 20ei1 (P. 20ei1), a bacterial species isolated from lagoon water, which contains pitrilysin genes that share similarities with human insulysin. Six pqqL-related genes were identified in P. 20ei1 for this study. The research methodology involved bioinformatic studies, bacterial cell culture in various media, RNA extraction, purification, and cDNA synthesis. Quantitative PCR analysis was performed to analyze gene expression levels in different cDNA samples. The bacteria grown in the medium with insoluble phosphate has shown higher expression of selected genes …

Gardner-Webb Incoming First-Year Students Form Strong Bonds In Living-Learning Communities (Llc), Office Of University Communications

Gardner-Webb NewsCenter Archive

After successfully introducing Gardner-Webb University’s first living-learning community (LLC) last year, the Division of Student Success in collaboration with the Office of Housing and Residence Education added two more LLCs for the 2024 Fall Semester. Incoming first-year students could choose to participate in one of three LLCs: Faith, STEM or Honors.

Structure Of A Model Lipid Membrane Oxidized By Human 15-Lipoxygenase-2, Jamil Nemri, Cosme Morales, Nathaniel C. Gilbert, Jaroslaw Majewski, Marcia E. Newcomer, Crystal M. Vander Zanden

Faculty Publications

Enzyme-mediated lipid oxidation is an important regulatory event in cell signaling, with oxidized lipids being potent signaling molecules that can illicit dramatic changes in cell behavior. For example, peroxidation of an arachidonoyl poly-unsaturated fatty acid by the human enzyme 15-lipoxygenase-2 (15-LOX-2) has been associated with formation of atherosclerotic plaques. Previous work on synthetically oxidized membranes has shown that oxidized lipid tails will change their conformation to facilitate interactions between the peroxide group and the lipid headgroups. However, this phenomenon has not been directly observed for a lipid membrane that has undergone enzyme-catalyzed oxidation. In this study, we report on the …

Adapting For Accessibility: How Secondary Humanities Teachers Modify Open Educational Resources Using The Universal Design For Learning Framework, Christine Nick

Theses and Dissertations

The purpose of this study was to examine how secondary humanities teachers modify Open Educational Resources (OERs) to align with the Universal Design for Learning (UDL) framework. Originally developed to democratize access to educational content, OERs have become widely used across K–12 settings in the U.S., particularly following initiatives such as the Common Core standards and the U.S. Department of Education’s #GoOpen Project. Despite the growing adoption of OERs, limited research has addressed how teachers adapt these materials to meet the diverse needs of their students, especially through the lens of accessibility and inclusivity. Using the UDL framework, this descriptive …

Faculty Senate Meeting, 59th Senate Minutes (12/10/2024), Csusb Faculty Senate

CSUSB Faculty Senate records

No abstract provided.

Tyler Snodgrass, Composition, December 10, 2024 [Program], University Of Northern Iowa. School Of Music.

Music Recital Programs

Program of a music recital given by faculty, students, or guest artists from the School of Music at the University of Northern Iowa.

Teacher’S Perspectives Regarding Kindergarten Students’ Behaviors And Social Skills Post-Pandemic, Latalia Middlebrook Robbins

Walden Dissertations and Doctoral Studies

Kindergarten teachers and support professionals in the social-emotional community within a local school district experienced changes in student behaviors and social skills since returning to in-person schooling following the pandemic. After COVID-19, teachers found themselves engaging students who presented a lack of social skill development, contributing to the behaviors within the classroom microsystem. This study used Urie Bronfenbrenner’s ecological systems theory to support research efforts to examine how learning environments and interactions contributed to students’ preparation for Kindergarten. The research explored 12 Kindergarten teachers' and support professionals' perspectives concerning Kindergarten student behaviors and social skills. The research design was an …

Effective Strategies For Acquiring Financing For Small Businesses Owned By Women, Sharon R. Crumblin

Walden Dissertations and Doctoral Studies

Women-owned small and medium-sized enterprises (SMEs) often face significant challenges in securing funding due to a lack of networks and resources, which limits their access to both traditional and nontraditional financing options. Grounded in the social feminist theory, the purpose of this qualitative pragmatic inquiry was to explore effective strategies women-owned SMEs in the northeastern United States can use to secure financing for startup and daily operations. Participants were seven women who successfully operated small service-based businesses in the northeastern United States, implementing strategies that sustained their businesses for at least two years. Data were collected using semistructured interviews. Through …

Using Geogebra To Foster Imagination And Creativity To Build Mathematics Confidence In A Stem World, Joseph M. Furner

Transformations

Math teachers can better prepare all student for a STEM world using computer software like GeoGebra to better prepare our youth for such high-tech careers like that of which Einstein was part of while also emphasizing and fostering creativity in the learning of mathematics. It is critical we have young learners who are confident in their ability to do math and be creative. Teachers today need to check dispositions toward mathematics and address math anxiety while building math confidence in their students. In an ever-advancing world of technology, math teachers need to incorporate such emerging technologies like GeoGebra into the …

Rachel’S Saga: Using Adolescent Literature In The Mathematics Classroom As A Form Of Bibliotherapy To Help Students Overcome Math Apprehension, Joseph M. Furner

Transformations

Math anxiety is prevalent and an understanding of mathematics is critical in an increasingly technological/STEM society, teachers must play a role in reducing the levels of math anxiety of learners. More recently, children's and adolescent literature has been recognized now as a means to teaching mathematics to students through the use of stories to make the math concepts relevant and meaningful. Literature may be used as a therapy to reach students who may be frustrated with math and/or who experience math anxiety. Story and picture books such as Math Curse (Scieszka & Smith, 1995) and A Gebra Named Al (Isdell, …

Advantages And Disadvantages Of Technology In The Mathematics Classroom, Francena D. Gargaro

Transformations

The integration of technology into teaching pedagogy, particularly in mathematics instruction, has been a subject of significant. This paper examines the impact of utilizing technology for mathematics education. It reviews multiple categories of technological tools available for classroom use, including hardware, software, and online resources, and discusses their potential benefits and drawbacks. Positive aspects of technology integration include personalized learning experiences, increased engagement and collaboration, and enhanced visualization and conceptual understanding. However, challenges such as dependency on technology, loss of conceptual understanding, distraction, and the widening achievement gap due to inequity are also addressed. The paper explores the role of …

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Transformations

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Twn Holiday Party, The Women's Network

Campus Events

No abstract provided.

Guided Meditation And Mindfulness Vr, Douglas And Judith Krupp Library

Campus Events

No abstract provided.

December 10, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Regulatory Dynamics Of Arginine Metabolism In Staphylococcus Aureus, Itidal Reslane, Gabrielle F. Watson, Luke D. Handke, Paul D. Fey

Open Access Articles Funded by the University of Nebraska Open Access Publishing Agreements or the former UNO Open Access Fund

Staphylococcus aureus is a highly significant pathogen with several well studied and defined virulence factors. However, the metabolic pathways that are required to facilitate infection are not well described. Previous data have documented that S. aureus requires glucose catabolism during initial stages of infection. Therefore, certain nutrients whose biosynthetic pathway is under carbon catabolite repression and CcpA, including arginine, must be acquired from the host. However, even though S. aureus encodes pathways to synthesize arginine, biosynthesis of arginine is repressed even in the absence of glucose. Why is S. aureus a functional arginine auxotroph? This review discusses recently described regulatory …

Energy Harvesting Devices And Sensors, And Methods Of Making And Use Thereof, Paul M. Thibado, Pradeep Kumar

Patents Granted

Disclosed herein are energy harvesting devices and sensors, and methods of making and use thereof. The energy harvesting devices can comprise a membrane disposed on a substrate, wherein the membrane comprises a two-dimensional (2D) material and one or more ripples; and a component electrically, magnetically, and/or mechanically coupled to the membrane and/or the substrate, such that the component is configured to harvest energy from the membrane. The sensors can comprise a membrane disposed on a substrate, wherein the membrane comprises a two-dimensional material one or more ripples; and a component electrically, magnetically, and/or mechanically coupled to the membrane and/or the …

Response Of Mucinous Breast Carcinoma To Neoadjuvant Chemotherapy, Berkay Kiliç, Burak İlhan

Turkish Journal of Medical Sciences

Background/aim: Mucinous breast carcinoma (MC) is thought to be a favorable-differentiated form of invasive breast cancer and is rarely preferred for neoadjuvant chemotherapy (NAC). The study aimed to define the response of MCs to NAC.Materials and methods: The study reviewed the demographic, clinicopathologic characteristics, management, and follow-up data of 70 patients diagnosed with MC between May 2010 to December 2020 by examining patients’ historical files and oncology records.Results: The median age, tumor size, and follow-up period of patients were respectively 52.9 (range 32 to 87) years, 25.8 (range 8 to 88) mm, and 61.5 (range 18 to 143) months. Out …

A New Scoring In Differential Diagnosis: Multisystem Inflammatory Syndrome Or Adenovirus Infection?, Mustafa Gençeli̇, Talha Üstüntaş, Özge Akcan, Si̇nan Saylik, Fati̇h Ercan, Sevgi̇ Pekcan, Si̇pi̇l Gençeli̇, Sevgi̇ Durmuş, Mustafa Argun

Turkish Journal of Medical Sciences

Background/aim: Differentiating multisystem inflammatory syndrome in children (MIS-C) from adenovirus infection (AI) can be challenging due to similar clinical and laboratory findings. This study aimed to identify distinguishing characteristics and develop a scoring system to facilitate accurate diagnosis.Materials and methods: A comprehensive review of medical records was undertaken for 108 MIS-C cases and 259 patients with confirmed AI. A comparison of laboratory data and clinical findings was conducted across patient groups through appropriate statistical tests.Results: MIS-C patients were significantly older than AI patients (p<0.001). Diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness symptoms were more frequently associated with MIS-C (p<0.001), while cough and runny nose were significantly more common in AI (p<0.001). Lymphopenia and thrombocytopenia were more prevalent in MIS-C patients (p<0.001). AI and MIS-C were scored by giving 1 point each to the parameters that created the difference. For AI, ≤60 months, presence of cough, runny nose and absence of diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy, tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness, lymphopenia, thrombocytopenia and CRP <124.5 mg/L were determined as each parameter plus one point. A total score above 14 could predict AI with a high degree of accuracy sensitivity values stood at around 97.5% and specificity at 92.6%.Conclusion: The proposed inpatient scoring system, when used in conjunction with polymerase chain reaction testing, may improve the early differentiation of AI and MIS-C. This approach could help reduce unnecessary testing and optimize resource allocation. Further research with larger samples should investigate this novel scoring system to establish its reliability and generalizability.

Implementation Of Written Asthma Action Plan Among Asthma Patients In Türkiye: A Multicenter, Cross-Sectional, Descriptive Study, Kurtuluş Aksu, Gürgün Tuğçe Vural Solak, Pinar Mutlu, Levent Cem Mutlu, Görkem Vayişoğlu Şahi̇n, Burcu Yormaz, Ayli̇n Çapraz, Ezgi̇ Erdem Türe, Yavuzalp Solak, Funda Aksu

Turkish Journal of Medical Sciences

Background/aim: In our country, there is no data on whether the clinicians give an asthma action plan to implement to patients followed up with a diagnosis of asthma, and whether patients can manage their treatment according to this plan. The present study aimed to determine the use of asthma action plans in our country and the awareness levels of patients about the plan.Materials and methods: Multicenter, cross-sectional descriptive study was conducted in outpatient immunology and allergy and pulmonology clinics of secondary and tertiary health-care centers. Adults asthmatics filled out a case registration form regarding age, gender, educational status, duration of …

High Sacral Slope, Lumbar Lordosis, And Sacral Slope-To-Pelvic Incidence Ratio Are Associated With New Bone Formation In Ankylosing Spondylitis, Aysun Aksoy, Cemal Gündoğmuş, Mehmet Kesi̇mer, Kemal Nas, İkram Duman, Gazanfer Eki̇nci̇, Murat Bezer, Pami̇r Atagündüz

Turkish Journal of Medical Sciences

Background/aim: Syndesmophyte formation appears to be site specific in Ankylosing spondylitis(AS),and new bone formation seems to occur in regions of micro-trauma that are prone to tensile forces.Pelvic and spinal parameters are unique for individuals. Pelvic tilt and sacral slope are important anatomical features that compensate in harmony in keeping the sagittal balance. After puberty, the sacral slope shapes the lumbar lordosis, whereas the pelvic incidence is set to an individual constant. This study aims to analyze the properties of pelvic parameters in AS patients with and without syndesmophyte formation in the spine after 15years of disease duration.Materials and methods:Whole spine …

Comparison Of Rigid And Elastic Registration Methods In Software-Based Targeted Prostate Biopsy: A Multi-Center Cohort Study, Serhat Çeti̇n, Serdar Çeli̇k, Murat Koparal, Güven Aslan, Sertaç Yazici, Bahadir Şahi̇n, Si̇nan Sözen, Levent Türkeri̇

Turkish Journal of Medical Sciences

Background/Aim: This study aims to compare the success rates of rigid registration (RR) and elastic registration (ER)systems in diagnosing all cancers and clinically significant prostate cancer (csPC) in software-based targeted prostate biopsies (TPBs) by performing matching analysis.Materials and Methods: The data of 2,061 patients from six centers where software-based TPB was performed were used. All cancer and csPC detection rates of the RR and ER systems were compared following Mahalanobis distance matching within the propensity score caliper method. Logistic regression analysis was applied to identify factors predicting clinically insignificant prostate cancer (ciPC) and csPC diagnoses. Additionally, the International Society of …

Transition Of Patients With Systemic Lupus Erythematosus From Pediatric To Adult-Oriented Rheumatology Care, Seher Şener, Gözde Yardimci, Ezgi̇ Batu, Levent Kiliç, Ümmüşen Kaya Akça, Müşerref Kasap Cüceoğlu, Zeynep Balik, Özge Başaran, Yelda Bi̇lgi̇ner, Şule Apraş Bi̇lgen, Seza Özen

Turkish Journal of Medical Sciences

Background/aim: The transition from pediatric to adult-oriented care for individuals with juvenile-onset systemic lupus erythematosus (SLE) poses significant challenges. This study aims to assess the outcomes of transitioning patients with juvenile-onset SLE from pediatric to adult-oriented care.Materials and Methods: Patients with juvenile-onset SLE were included. They were transferred in face-to-face meetings where at least one pediatric rheumatologist and one adult rheumatologist were present (the transition time: October-December 2020).Results: The median (25th-75th percentiles) age at diagnosis and the time of the first examination at an adult-oriented rheumatology department of 65 SLE patients were 14.3 (10.9-15.1) years and 19.2 (18.5-20.4) years, respectively …

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

Confident Witness: Evangelism & Apologetics For The 21st Century, Jeffrey Stevenson

Witness

No abstract provided.

Lipid Discovery Enabled By Sequence Statistics And Machine Learning, Priya M. Christensen, Jonathan Martin, Aparna Uppuluri, Luke R. Joyce, Yahan Wei, Ziqiang Guan, Faruck Morcos, Kelli L. Palmer

School of Podiatric Medicine Publications

Bacterial membranes are complex and dynamic, arising from an array of evolutionary pressures. One enzyme that alters membrane compositions through covalent lipid modification is MprF. We recently identified that Streptococcus agalactiae MprF synthesizes lysyl-phosphatidylglycerol (Lys-PG) from anionic PG, and a novel cationic lipid, lysyl-glucosyldiacylglycerol (Lys-Glc-DAG), from neutral glycolipid Glc-DAG. This unexpected result prompted us to investigate whether Lys-Glc-DAG occurs in other MprF-containing bacteria, and whether other novel MprF products exist. Here, we studied protein sequence features determining MprF substrate specificity. First, pairwise analyses identified several streptococcal MprFs synthesizing LysGlc-DAG. Second, a restricted Boltzmann machine-guided approach led us to discover an …

Diverse Possibilities Of Shakespeare: Teaching Twelfth Night Through A Queer Lens, Julia Ritzler

Honors Projects

This project seeks to understand the ways in which Queer Theory can be applied to secondary language arts education to enhance students' understanding of identity and gender in literature. For the purposes of this project, Shakespeare’s Twelfth Night is being used as a case study text. This project includes a thorough analysis of Twelfth Night through a queer lens, a literature review of Queer Theory and educational pedagogy, a block plan and related instructional and assessment materials, a rationale for the block plan, and project limitations and implications for future research. By analyzing scholarly texts and applying the theories within …

Guideline-Directed Medical Therapy After Hospitalization For Acute Heart Failure: Insights From The Connect-Hf, Satoshi Shoji, Lisa Kaltenbach, Bradi B. Granger, Gregg C. Fonarow, Hussein R. Al-Khalidi, Nancy M. Albert, Javed Butler, Larry A. Allen, David E. Lanfear, Jennifer T. Thibodeau, Brittany M. Chapman, Sandra M. Oliver-Mcneil, G. Michael Felker, Ileana L. Piña, Christopher B. Granger, Adrian F. Hernandez, Adam D. Devore

Division of Cardiology Faculty Papers

BACKGROUND: Significant gap remains in the implementation of guideline-directed medical therapy (GDMT) in patients with heart failure after a hospitalization. We aimed to evaluate the use and titration of GDMT at discharge and over a 12-month period after hospital discharge and to identify factors associated with GDMT use and titration.

METHODS AND RESULTS: The CONNECT-HF (Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure) trial evaluated the effect of a hospital and postdischarge quality improvement intervention in participants with heart failure with reduced ejection fraction. In this secondary analysis, we examined use and titration to at least …

Art399 Portfolio, Kristian Canada

Professional Practices (ART 399)

I value a synergistic use of color or value. Additionally, using details that can be seen working conjointly to further the level of my art. The mediums I enjoy working with are charcoal, oil paint, graphite, and clay. Most of my work is illustrated in black and white with my main medium being charcoal due to its ability to form and cast by using layers. I use this element to add expressive additions, shading, and line work to my art.

The ideas that I want to focus my work on are freedom of expression and creation where I can simply …