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Articles 451 - 480 of 194707
Full-Text Articles in Entire DC Network
Maga Goes To Panama, Ruti G. Teitel
The Whole Gall Of Wax, Jethro K. Lieberman
Addressing Unprofessional Behaviors In The Clinical Learning Environment: Lessons From A Multi-Year Virtual, Intergenerational, Interdisciplinary Workshop, Jocelyn Greely, Yesenia Rojas-Khalil, Doris Kung, Anne Gill, Nadia Ismail, Nital Appelbaum
Addressing Unprofessional Behaviors In The Clinical Learning Environment: Lessons From A Multi-Year Virtual, Intergenerational, Interdisciplinary Workshop, Jocelyn Greely, Yesenia Rojas-Khalil, Doris Kung, Anne Gill, Nadia Ismail, Nital Appelbaum
Faculty, Staff and Students Publications
INTRODUCTION: Optimizing the clinical learning environment (CLE) is a medical education priority nationwide.
MATERIALS AND METHODS: We developed a virtual, one-hour workshop engaging students, housestaff and faculty in small-group discussions of five case scenarios adapted from reported unprofessional behaviors in the CLE, plus didactics regarding mistreatment, microaggressions and bystander interventions.
RESULTS: Over two sessions (2021-2022), we engaged 340 students and 73 faculty/housestaff facilitators. Post-session surveys showed significant improvement in participants' ability to recognize and respond to challenges in the CLE.
DISCUSSION: Our innovative workshop, including scenarios derived from institutional reports of unprofessional behaviors, advanced participants' knowledge and commitment to improve …
Approved Car-T Therapies Have Reproducible Efficacy And Safety In Clinical Practice, Jonathan Pan, Premal Lulla
Approved Car-T Therapies Have Reproducible Efficacy And Safety In Clinical Practice, Jonathan Pan, Premal Lulla
Faculty, Staff and Students Publications
CAR-T cell therapy has established itself as a highly effective treatment for hematological malignancies. There are currently six commercial CAR-T products that have been FDA approved for diseases such as B-ALL, LBCL, MCL, FL, MM, and CLL/SLL. "Real-world" studies allow us to evaluate outcomes from the general population to determine their efficacy and safety compared to those who were included in the original trials. Based on several well conducted "Real-world" studies that represent diverse populations, we report that outcomes from the original trials that led to the approval of these therapies are comparable to those in practice.
Byu Law School Faculty Listing
Byu Law Review Subscription Information
What Is Deeply Rooted In The Constitution?, Thomas P. Crocker
What Is Deeply Rooted In The Constitution?, Thomas P. Crocker
BYU Law Review
In a series of cases stretching over a century, the Court made a right’s roots a constitutive feature of its identity. Highlighting the analytic centrality of deep roots to the recognition of rights, Dobbs v. Jackson Women’s Health withdrew prior judicial recognition of a woman’s right to reproductive choice, arguing that such a right was not properly rooted in the American legal tradition. But what does it mean for a right to have deep roots? A surprising feature of American constitutionalism is that there is no single answer to the basic analytic question of what it means for a right …
Is An Autonomous Vehicle A Roller Coaster Or A Hollywood Film? Trust, Safety, And Industry Self-Regulation, Tracy Hresko Pearl
Is An Autonomous Vehicle A Roller Coaster Or A Hollywood Film? Trust, Safety, And Industry Self-Regulation, Tracy Hresko Pearl
BYU Law Review
Regulation of autonomous vehicles continues to be a daunting task in the United States, and the federal government has not yet succeeded in creating a regulatory scheme that intelligently addresses the risks and benefits of these vehicles. There are multiple reasons for this regulatory lag. Autonomous vehicles are developing at such a rapid pace that lawmakers, who often struggle with technological literacy, struggle to keep up. Additionally, government agencies lack the level of expertise, experience, and data that the industry possesses.
Industry self-regulation offers a meaningful alternative for increasing the safety of autonomous vehicles and building consumer trust. The success …
“Whoever Invents Or Discovers”: Artificial Intelligence And The Case For Joint Inventorship, Seth F. Littleford
“Whoever Invents Or Discovers”: Artificial Intelligence And The Case For Joint Inventorship, Seth F. Littleford
BYU Law Review
Artificial intelligence (AI) is increasingly important in the modern world. Given its fidelity to—and, in some cases, its surpassing of—human performance, people rely upon AI in myriad settings. The AI era is already here, and the technological advancements to come are even more mind-boggling. The United States Patent and Trademark Office (USPTO) has seen a significant increase in patent applications claiming inventions pertaining to AI, but how does the patent system handle when AI invents?
The U.S. Court of Appeals for the Federal Circuit recently held in Thaler v. Vidal that the Patent Act requires inventors listed on patent applications …
Into The Sunset: Divorcing Families Need Their Slice Of The Tcja Reversions, John C. Mcdonald
Into The Sunset: Divorcing Families Need Their Slice Of The Tcja Reversions, John C. Mcdonald
BYU Law Review
On its path to sufficiently offsetting its major cut to the corporate income tax rate in 2017, Congress turned to a surprising source for funds: the alimony support payments of recently divorced families. Alimony’s inclusion/deduction regime in §§ 71 and 215 of the Code allowed divorcing couples to reach mutually beneficial divorce agreements for over half a century until it was unceremoniously repealed by the Tax Cuts and Jobs Act of 2017 with a striking lack of satisfying legislative justifications. This Note suggests that in evaluating the impact of the repeal, Congress and others have failed to consider an important …
Saving Camelot? Nil And The Future Of Amateurism, William W. Berry Iii
Saving Camelot? Nil And The Future Of Amateurism, William W. Berry Iii
BYU Law Review
This Article explores the future of intercollegiate athletics with a diminished (and perhaps even disappearing) amateurism model. Specifically, the Article argues that athletic conferences are in the best position to “save Camelot”—to preserve the aspects of college sports that make them beloved and distinctive—while at the same time realistically accounting for an evolving economic and legal landscape.
In Part I, the Article describes the economics of the NCAA’s current amateurism model. Part II explores the recent changes to the NCAA’s amateurism model in light of the Supreme Court’s decision in Alston v. NCAA and the widespread adoption of state name, …
The Prosecutor Vacancy Crisis, Adam M. Gershowitz
The Prosecutor Vacancy Crisis, Adam M. Gershowitz
BYU Law Review
There is a prosecutor vacancy crisis in the United States. Prosecutors are quitting in droves and there are few applicants to replace them. In Houston and Los Angeles, more than 15% of prosecutor positions are open. In Detroit, the vacancy rate exceeds 20%. In Alameda, 25% of prosecutor positions are empty. And in Miami, a staggering 33% of prosecutor positions are unfilled. The situation is equally dire in many large and small counties across the nation.
Drawing on data and interviews from more than two-dozen district attorney’s offices, this Article documents how low salaries, massive caseloads, lack of remote work …
Dynamic And Concordance-Assisted Learning For Risk Stratification With Application To Alzheimer’S Disease
Faculty, Staff and Student Publications
Dynamic prediction models capable of retaining accuracy by evolving over time could play a significant role for monitoring disease progression in clinical practice. In biomedical studies with long-term follow up, participants are often monitored through periodic clinical visits with repeat measurements until an occurrence of the event of interest (e.g. disease onset) or the study end. Acknowledging the dynamic nature of disease risk and clinical information contained in the longitudinal markers, we propose an innovative concordance-assisted learning algorithm to derive a real-time risk stratification score. The proposed approach bypasses the need to fit regression models, such as joint models of …
Head-To-Head Comparison Of Aptamer- And Antibody-Based Proteomic Platforms In Human Cerebrospinal Fluid Samples From A Real-World Memory Clinic Cohort, Maria Capdevila, Josep Blázquez-Folch, Oscar Sotolongo-Grau, Andrea Miguel, Laura Montrreal, Pamela Martino-Adami, Asif Khan, Adelina Orellana, Yun Ju Sung, Ruth Frikke-Schmidt, Natalie Marchant, Jean Charles Lambert, Maitée Rosende-Roca, Montserrat Alegret, Maria Victoria Fernández, Marta Marquié, Sergi Valero, Lluís Tárraga, Alfredo Ramírez, Mercè Boada, Bart Smets, Alfredo Cabrera-Socorro, Agustín Ruiz
Head-To-Head Comparison Of Aptamer- And Antibody-Based Proteomic Platforms In Human Cerebrospinal Fluid Samples From A Real-World Memory Clinic Cohort, Maria Capdevila, Josep Blázquez-Folch, Oscar Sotolongo-Grau, Andrea Miguel, Laura Montrreal, Pamela Martino-Adami, Asif Khan, Adelina Orellana, Yun Ju Sung, Ruth Frikke-Schmidt, Natalie Marchant, Jean Charles Lambert, Maitée Rosende-Roca, Montserrat Alegret, Maria Victoria Fernández, Marta Marquié, Sergi Valero, Lluís Tárraga, Alfredo Ramírez, Mercè Boada, Bart Smets, Alfredo Cabrera-Socorro, Agustín Ruiz
Faculty, Staff and Student Publications
High-throughput proteomic platforms are crucial to identify novel Alzheimer’s disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan® 7k) and antibody-based (Olink® Explore 3k) proteomic platforms in cerebrospinal fluid (CSF) samples from the Ace Alzheimer Center Barcelona real-world cohort. Intra- and inter-platform reproducibility were evaluated through correlations between two independent SomaScan® assays analyzing the same samples, and between SomaScan® and Olink® results. Association analyses were performed between proteomic measures, CSF biological traits, sample demographics, and AD endophenotypes. Our 12-category metric of reproducibility combining correlation analyses identified 2428 highly reproducible SomaScan CSF measures, …
Linking Transcriptome And Morphology In Bone Cells At Cellular Resolution With Generative Ai
Linking Transcriptome And Morphology In Bone Cells At Cellular Resolution With Generative Ai
Faculty, Staff and Student Publications
Recent advancements in deep learning (DL) have revolutionized the capability of artificial intelligence (AI) by enabling the analysis of large-scale, complex datasets that are difficult for humans to interpret. However, large amounts of high-quality data are required to train such generative AI models successfully. With the rapid commercialization of single-cell sequencing and spatial transcriptomics platforms, the field is increasingly producing large-scale datasets such as histological images, single-cell molecular data, and spatial transcriptomic data. These molecular and morphological datasets parallel the multimodal text and image data used to train highly successful generative AI models for natural language processing and computer vision. …
The Radical Oxidation Of Hydroxyacetone: An Insight Into The Reaction Mechanism And Potential Tetraoxide Intermediates, Edward Buck
Master's Theses
This thesis presents the reaction of hydroxyacetone, a common volatile organic compound (VOC), with chlorine radicals in the presence of oxygen. Chapter one explores VOCs and their specific reactions and how tetraoxide intermediates could be formed from them. Chapter two analyses the experimental and computational methods used and the key theoretical concepts behind these methods. Experimental data was collected using multiplexed photoionization mass spectrometry at the Advanced Light Source Chemical Transformations Beamline, Lawrence Berkeley National laboratory. This data is combined with theoretical data using the CBS-QB3 composite method to determine the key reaction intermediates and mechanisms.
The main chapter of …
Research Focusing On Protective Factors: From Individual To Community And Societal Strengths, Maria Caridad H. Tarroja
Research Focusing On Protective Factors: From Individual To Community And Societal Strengths, Maria Caridad H. Tarroja
Asia-Pacific Social Science Review
No abstract provided.
“The People Deserve Better Governance”: Examining The Letters Of Filipino High School Students To The Next President Of The Philippines, Ma. Glenda Lopez Wui, Jessica Sandra R. Claudio, Rosselle Trishia M. Reyes, Carl Russel R. Reyes, Jie Zhang, Enrique Niño P. Leviste
“The People Deserve Better Governance”: Examining The Letters Of Filipino High School Students To The Next President Of The Philippines, Ma. Glenda Lopez Wui, Jessica Sandra R. Claudio, Rosselle Trishia M. Reyes, Carl Russel R. Reyes, Jie Zhang, Enrique Niño P. Leviste
Asia-Pacific Social Science Review
The study examined the results of the civic writing project “Letter to the Next President of the Philippines,” where grades 9-10 students were asked to write a letter to the next president about social problems that they wanted their future leader to resolve and why. The study analyzed the students’ letter topics according to their school type and location, gender, and the students’ sources of information for their civic writing. The letters (N=322) were written by students from urban and rural, and public and private schools across the country in March-May 2022 before the Philippine presidential election. The quantitative analysis …
Entrepreneurial Self-Efficacy And Extreme Decision-Making: The Unexpected Influence Of Entrepreneurial Personality, Chatchai Chatpunyakul, Sarist Gulthawatvichai
Entrepreneurial Self-Efficacy And Extreme Decision-Making: The Unexpected Influence Of Entrepreneurial Personality, Chatchai Chatpunyakul, Sarist Gulthawatvichai
Asia-Pacific Social Science Review
The two main goals of this paper are to (a) examine how entrepreneurial self-efficacy (ESE) affects decision- making among nascent entrepreneurs and (b) examine the moderating role of entrepreneurial personality. A 2x2 between- subjects online randomized experiment was carried out. A sample of 48 Bangkok-based business school students who functioned as the study’s nascent entrepreneurs’ representatives was used to collect data for two sessions. Multiple linear regression was used to assess the research hypotheses. The findings show that extreme decision-making and nascent entrepreneurs’ ESE are positively correlated; an increase in ESE causes an increase in extreme decision-making. The effect of …
Development And Validation Of The Malaysia Cybervictimization Scale For Adolescents In Malay And Chinese Version, Poh Chua Siah, Xiang Yi Tee, Chee-Seng Tan, Joanna Tjin Ai Tan, Komathi Lokithasan, Sew Kim Low, Chin Choo Yap
Development And Validation Of The Malaysia Cybervictimization Scale For Adolescents In Malay And Chinese Version, Poh Chua Siah, Xiang Yi Tee, Chee-Seng Tan, Joanna Tjin Ai Tan, Komathi Lokithasan, Sew Kim Low, Chin Choo Yap
Asia-Pacific Social Science Review
The increasing rate of cybervictimization has been documented in various countries, including Malaysia. However, there is a dearth of measurement tools with sound psychometric properties suitable for the Malaysian context. To address this methodological gap, the Malaysia Cybervictimization Scale for Adolescents (MyCVS-A) was developed based on qualitative inputs from adolescents in Malaysia. It was subsequently translated into Malay (MyCVS-A-M) and Chinese (MyCVS-A-C). Two studies were conducted to examine the psychometric properties of these two translated versions. In Study 1, 281 secondary school students completed the MyCVS-A-M, the Malay version of the cybervictimization subscale of the European Cyberbullying Intervention Project Questionnaire …
High-Frequency Gold Price Forecasting: Optimizing Multi-Layer Perceptron With Genetic Algorithm, Vrtagic Sabahudin, Fatih Dogan
High-Frequency Gold Price Forecasting: Optimizing Multi-Layer Perceptron With Genetic Algorithm, Vrtagic Sabahudin, Fatih Dogan
Materials Science and Engineering Faculty Research & Creative Works
Accurately forecasting gold price actions is critical in financial markets due to gold's role as a safe-haven asset. This paper addresses the challenge of forecasting gold prices by applying a Genetic Algorithm (GA) with a Multi-Layer Perceptron (MLP) model. The research exploits historical financial data from various instruments, including gold futures, Bitcoin, and key currency pairs, to improve prediction accuracy. By optimizing the MLP's hyper parameters through GA, the model efficiently captures complex relationships in high-frequency data, achieving a remarkable R² score of 0.9993. This level of precision demonstrates the model's potential for providing actionable insights for traders and investors. …
Roselle And Red Ginger: A Potential Combination Of Medicinal Plants For Hypertension Therapy, Ranum Wanudya Yunas, Siti Irma Rahmawati, Fadlina Chany Saputri, Asep Bayu, Giuseppina Chianese, Masteria Yunovilsa Putra
Roselle And Red Ginger: A Potential Combination Of Medicinal Plants For Hypertension Therapy, Ranum Wanudya Yunas, Siti Irma Rahmawati, Fadlina Chany Saputri, Asep Bayu, Giuseppina Chianese, Masteria Yunovilsa Putra
Pharmaceutical Sciences and Research
Hypertension is a prevalent cardiovascular condition that significantly increases the risk of heart disease and stroke. Effective management is essential to prevent severe complications. Roselle (Hibiscus sabdariffa L.) and red ginger (Zingiber officinale var. rubrum) are two medicinal plants known for their antihypertensive properties. Roselle contains bioactive compounds such as anthocyanins that exhibit vasodilatory and angiotensin-converting enzyme (ACE) inhibition, while red ginger is rich in gingerols and shogaols, which possess anti-inflammatory and vasodilatory properties. The complementary mechanisms of action of these two plants, including ACE inhibition, antioxidant activity, and modulation of vascular tone, result in a more …
Investigating The Bioactivity Potential And Standardization Of Two Stingless Bee Propolis From East Kalimantan, Paula Mariana Kustiawan, Muhammad Ali Syahbana, Rika Pratika, Muhammad Nor Ichsan, Ika Ayu Mentari, Indah Hairunnisa, Irfan Muris Setiawan, Putri Hawa Syaifie, Donny Ramadhan, Chanpen Chanchao
Investigating The Bioactivity Potential And Standardization Of Two Stingless Bee Propolis From East Kalimantan, Paula Mariana Kustiawan, Muhammad Ali Syahbana, Rika Pratika, Muhammad Nor Ichsan, Ika Ayu Mentari, Indah Hairunnisa, Irfan Muris Setiawan, Putri Hawa Syaifie, Donny Ramadhan, Chanpen Chanchao
Pharmaceutical Sciences and Research
The standardization of raw materials from nature is essential before they are made into products. Until now, there is still limited information regarding the standardization of propolis from stingless bees. This research aims to determine the bioactivity with standardized specific and non-specific parameters of ethanol extracts from Homotrigona apicalis and Homotrigona fimbriata propolis. The methods include organoleptic tests, tests for water-soluble and ethanol-soluble compound content, drying shrinkage tests, specific gravity tests, water content tests, metal contamination tests, phytochemical screening, and determining total phenolic and flavonoid content. The free radical scavenging capacity was measured using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, and antimicrobial …
Optimization Of External Disintegrating Materials In Wet Granulation Formulation Of Ondansetron Tablets, Yandi Permana, Syahrul Tuba, Taufik Riyadi, Sugindro Sugindro
Optimization Of External Disintegrating Materials In Wet Granulation Formulation Of Ondansetron Tablets, Yandi Permana, Syahrul Tuba, Taufik Riyadi, Sugindro Sugindro
Pharmaceutical Sciences and Research
Inadequate management of chemotherapy-induced side effects, including nausea and vomiting, can impact the healing response of cancer patients. Ondansetron, a preferred medication for the treatment, is classified as a biopharmaceutic classification system (BCS) class II drug, which limits its bioavailability. To enhance its solubility, sodium starch glycolate (SSG) and pregelatinized starch (PG) are used as super disintegrants. This study investigates the impact of these super disintegrants on ondansetron dissolution and identifies the optimal formulation. Ondansetron tablets were prepared using the wet granulation method, with nine formulations varying in SSG and PG concentrations (0%, 1%, 3%, 5%, and 7%). The tablets …
Utilizing Water Hyacinth (Eichhornia Crassipes) From Srandakan Bantul, Indonesia For ‘Bright Fever Patch’ As An Alternative Children’S Fever Therapy, Anggita Kamalia Niswara, Nabillah Ainun Kusrinanti, Rizqi Amalia Firdaus, Azis Ikhsanudin
Utilizing Water Hyacinth (Eichhornia Crassipes) From Srandakan Bantul, Indonesia For ‘Bright Fever Patch’ As An Alternative Children’S Fever Therapy, Anggita Kamalia Niswara, Nabillah Ainun Kusrinanti, Rizqi Amalia Firdaus, Azis Ikhsanudin
Pharmaceutical Sciences and Research
In 2022, Indonesia experienced a public health crisis involving acute kidney failure in children, traced to paracetamol syrup contaminated with ethylene glycol and diethylene glycol. This underscores the urgent need for safer antipyretic alternatives. This study investigates the antipyretic potential of transdermal patches formulated with ethanol extract of water hyacinth (Eichhornia crassipes) leaves sourced from Srandakan, Bantul, Yogyakarta. Extract concentrations of 0.8%, 1.0%, and 1.2% were tested, alongside a negative control (no extract) and a positive control (paracetamol). The patches underwent evaluations for organoleptic properties, weight uniformity (0.41±0.02 to 0.52±0.02 g), thickness (0.36±0.03 to 0.41±0.03 mm), water absorption …
Becoming Connective: Strengthening Diversity In Nursing Education, Melanie Jacobs
Becoming Connective: Strengthening Diversity In Nursing Education, Melanie Jacobs
Electronic Theses and Dissertations Archive
Abstract Diversity in the nursing profession does not match the demographic of patients in the United States and correcting this mismatch could positively impact health disparities in the country. This post-intentional phenomenological study examines the current relationship between nursing education, as the pipeline into the profession, and students from underrepresented racial and ethnic (URRE) groups in the nursing profession to offer movement into the development of a stronger connection. In this qualitative study, phenomenological and poststructural tenets were used to seek the phenomenon of becoming connective, the creative tendency toward connection between URRE and nursing education. Data were generated from …
Rdn Diagnosed Malnutrition At St. Jude Children’S Research Hospital: Onset To Resolution Using And/Aspen Criteria, Madison Domek
Rdn Diagnosed Malnutrition At St. Jude Children’S Research Hospital: Onset To Resolution Using And/Aspen Criteria, Madison Domek
Electronic Theses and Dissertations Archive
This quality improvement (QI) project investigates the incidence and management of malnutrition in pediatric oncology patients at St. Jude Children’s Research Hospital (SJCRH) from October 2022 to September 2023. The study aims to quantify malnutrition diagnoses made by registered dietitian nutritionists (RDNs) and to identify patients at higher risk of severe malnutrition based on their primary cancer diagnosis and clinic location. A total of 161 patients were identified, resulting in 238 documented instances of malnutrition, classified as mild, moderate, or severe. The majority of unresolved cases were attributed to inadequate follow-up, particularly in the Hematology Clinic, which had a 100% …