Digital Commons Network^™

From Elementary School To Doctoral Education: An Autoethnographic Journey, Gwendolyn D. Dailey

University of the Pacific Theses and Dissertations

Every child has a right to education, and their skin color should not determine their education quality. However, since the landmark case of Brown v. Board of Education (1954), it has been proven that race continues to matter in the success and failure of education (Delgado & Stefancic, 2001). The persistent achievement gaps between students of different racial and ethnic backgrounds, as well as the disparities in access to high-quality educational opportunities, demonstrate how race and ethnicity shape the educational experiences of students of color (Stanford Center for Education Policy Analysis, 2012). Unfortunately, stories such as Ruby Bridges of New …

Elaboration Of Diquinanes To Access Trifunctional Angular Triquinanes And Designed Dna Polymerase Α Inhibitors, Spencer M. Webber

University of the Pacific Theses and Dissertations

Natural products are of great significance to the pharmaceutical industry in the development of new drugs. Diquinane or bicyclo[3.3.0]octane is a conspicuous structural unit existing in the carbo-frameworks of a wide range of natural products such as alkaloids and terpenoids. These diquinane-containing molecules not only exhibit intriguing architectures, but also showcase a broad spectrum of significant bioactivities, which draw widespread attention from the global synthetic community. A more specific group of compounds containing a diquinane moiety with one extra 5-membered ring are called the angular triquinanes.In this work, we have developed a general synthetic scheme to the angular triquinanes. We …

The Impact Of Competency-Based Education And Learning Implementation On Technical Colleges Outcomes: Kuwait College For Technological Studies (Cts) Case Study, Mohammad Abdulmohsen Alshaiji

University of the Pacific Theses and Dissertations

Many colleges and training institutions have shifted to Competency-Based Education/Learning (CBE/L) after using the traditional time-credits approach. Students’ achievements and progress are accumulated, not only by credit hours for theoretical knowledge but also, through demonstrating their practical competences.

In CBE/L, students are assessed based on their ability to perform specific tasks using the knowledge and skills (competencies) required for each task in their academic course, regardless of how long such progression might take. The traditional method of learning was time-based on course credits, which last for a specific period of time, and through which students are learning more theoretical knowledge …

Impact Of A Culturally-Grounded And Interprofessional Approach To Managing Latino/Hispanic Patients At Risk For Or Diagnosed With Type 2 Diabetes Mellitus: A Pilot Study, Jahnavi Yalamanchili

University of the Pacific Theses and Dissertations

Background: Despite significant progress in diabetes research, there remain significant health disparities between Hispanic/Latino patients in the United States, particularly those with lower socioeconomic status, compared to non-Hispanic white patients. Previous studies have identified potential reasons behind these disparities, including the need for a multifaceted approach that addresses social determinants of health (SDOH) faced by patients. Social cognitive theory (SCT) stipulates that interventions that promote self-management by improving knowledge, self-efficacy, and problem-solving skills can be successful in improving health outcomes. However, there is a paucity of studies that have evaluated an interprofessional approach to providing culturally relevant care, in particular …

Effects Of Glyphosate-Based Herbicide Exposure On Life History, Stress Tolerance, And Microbiome—From Plasticity To Evolution, Jacob R. Whitlock

University of the Pacific Theses and Dissertations

Glyphosate (GLY) is the most used pesticide worldwide, and GLY-based herbicides (GBHs) can affect animals’ microbiomes and, in turn, their physiology and morphology. Environmental stressors can be mitigated by flexibility in life-history strategies, which can also dictate animal physiology and morphology. However, we lack an understanding of how GBH influences life-history strategies and stress tolerance, in addition to its effects across generations. Thus, I exposed the variable field cricket, Gryllus lineaticeps, to GBH within- and across-generations to examine the role of GBH in developmental plasticity and evolution. Specifically, I measured its effects on life-history traits (e.g., developmental duration and a …

Effects Of Fetal Bovine Serum On The Proteome And Secretome Of Pichia Pastoris, Kenneth L. Nguyen

University of the Pacific Theses and Dissertations

Komagataella pastoris, formerly known as Pichia pastoris, and hereafter referred to as Pichia, is a methylotrophic yeast widely employed as a recombinant protein factory for biotechnical and industrial purposes. P. pastoris boasts the ability to thrive at high cell densities, executes numerous post-translational modifications, and exhibits minimal secretion of endogenous proteins, thus greatly facilitating the expression and purification of recombinant proteins. Despite these advantages, Pichia still presents certain challenges as an expression system. Occasionally, recombinant proteins are retained within the cell and subject to degradation. Furthermore, Pichia falls short in matching the production capabilities of more widely used systems like …

The Role Of The Unfolded Protein Response In Fatty Liver Disease, Anusha L. Murshed

University of the Pacific Theses and Dissertations

The unfolded protein response (UPR) is composed of three highly conserved pathways (ATF6, IRE1, PERK). Cellular stressors induce protein misfolding and aggregation in the endoplasmic reticulum (ER). This signaling pathway maintains protein homeostasis when there is stress in the ER. When the UPR is activated, the eukaryotic initiation factor 2 alpha (eIF2α) becomes phosphorylated, which inhibits global mRNA translation. If ER stress remains chronically unmitigated, the UPR induces apoptosis. GADD34 and CReP shift in expression when the UPR is activated and work as phosphatases and dephosphorylate eIF2α in a feedback loop, allowing protein synthesis to resume. Several human diseases, including …

Impact Of Drug-Polymer Interactions On Stability In Simvastatin-Based Amorphous Solid Dispersions, Charina Lampa

University of the Pacific Theses and Dissertations

This study aimed to investigate the drug-polymer interactions between simvastatin (SIM) and three polymers [PVP-VA, HPMC-AS, and Soluplus® (SOL)] in amorphous solid dispersions (ASDs) prepared by hot melt extrusion (HME), and to understand the implications on physical stability. ASDs are of significant interest within the pharmaceutical industry for improving drug bioavailability. However, the amorphous nature of a drug in an ASD presents physical stability challenges. Utilizing novel applications of accessible tools such as ATR-FTIR or DSC aid in understanding the mechanisms of stabilization which are critical to the rational design of ASDs. ASDs were prepared using HME and were characterized …

Close To The Pain: Alternative Education And The Unheard Voices Of Young Adults’ Transformative Learning Experiences, Vicki Lynn Lock

University of the Pacific Theses and Dissertations

This dissertation focuses on amplifying the voices of marginalized students in alternative education, with an emphasis on the positive impact of resilience on their outcomes. The study addresses the challenges these students face, particularly those from BIPOC communities, in navigating educational systems that have historically marginalized them. The purpose of this qualitative research was to explore the experiences of BIPOC students in a Central Valley alternative education program, highlighting how nurturing relationships, resilience, and the fulfillment of basic needs contribute to their academic success and personal growth. Utilizing a framework that incorporates theories of resilience, educational equity, and transformative leadership, …

Filipina American Mothers’ Experiences Obtaining Services For Their Children With Autism Spectrum Disorder, Nina Chelle Boling

University of the Pacific Theses and Dissertations

Autism spectrum disorder (ASD) is a multifaceted developmental condition that manifests in early childhood, affecting various aspects of neurologic, biological, adaptive, social, linguistic, and cognitive functions. A timely and accurate diagnosis of ASD is crucial for effective intervention, promoting personal and social growth, and fostering independent adulthood. However, obtaining this diagnosis can pose challenges, particularly for people of color, who often encounter disparities in healthcare access compared to their White counterparts. This study aims to investigate the experiences of Filipina mothers raising children with ASD, specifically focusing on their journey to access appropriate autism services.

As of 2019, there were …

Understanding Latina/O/X Puente Alumni Student Experiences With Sense Of Belonging And Validation, Stephanie Teresa Razo

University of the Pacific Theses and Dissertations

The primary focus of this study was on how the Puente Project helps Latina/o/x community college students feel supported and validated. Additionally, it focused on how community and familial efforts can influence students’ experiences, and how the Puente Project leverages those forms of capital. Examining the lived experiences of Latina/o/x Puente community college alumni contributed to the study of retention and graduation initiatives for Latina/o/x students in the California Community College system. For this study, the participants chosen already completed the Puente program at a California Central Valley community college, transferred to a four-year institution, and either graduated with—or are …

On The Social Validity Of Teaching Children To Give A Polite Response, Nancy V. Ramirez

University of the Pacific Theses and Dissertations

Some children, including individuals diagnosed with autism spectrum disorder (ASD), may respond rudely when expressing their opinions about nonpreferred gifts or aspects of someone else’s appearance (Bergstrom et al., 2016; Saarni, 1984; Talwar et al., 2007; Xu et al., 2010). One proposed solution discussed in the literature to decrease rude responses in children involves teaching children to tell a socially appropriate lie, often referred to as prosocial lies, as an alternative response. These types of lies are defined as “lies that have some benefit for the lie recipient and are not intended to cause harm to another individual” (Popliger et …

Softening And Cross-Susceptibility: Exposure To Heat And Desiccation Reduces Future Stress Tolerance In An Insect, Lauren Harter

University of the Pacific Theses and Dissertations

The frequency and duration of environmental stressors, such as heat waves and drought, will continue to grow due to ongoing climate change, thereby increasing the likelihood that organisms will experience stressors consecutively. Exposure to one stressor can improve or impair future tolerance to the same stressor (i.e., hardening or softening, respectively), or enhance or reduce future tolerance to a different stressor (i.e., cross-protection or cross-susceptibility, respectively). Understanding whether stress improves or impairs animals’ abilities to withstand future stressors is critical for determining the physiological sensitivity of animals to ongoing climate change. Here, I evaluated the responses to consecutive heat and …

Plasticity In Response To Temperature Magnitude And Variation---From Life History To Thermal Tolerance And Coloration, Austin Rex Hoffman

University of the Pacific Theses and Dissertations

Warming associated with climate change has many direct and downstream effects on animals. For example, warmer developmental temperatures can improve heat tolerance and reduce insect melanization, which is related to coloration, thermoregulation, immunity, desiccation resistance, and potentially life-history traits, such as investment into reproduction and dispersal. Increased temperature variation is also a feature of climate change, and it may have a larger impact on animals than warming. However, I lack insight into the combined effects of temperature magnitude and variability on important traits of life history, thermal tolerance, and coloration. Thus, I integrated temperature variation into thermal performance using a …

God With Us: Discipleship Of The Mind, John C. Peckham

Faculty Publications

No abstract provided.

Using Early Responses To Wikipedia And Google To Consider Chatgpt, David A. Hurley

University Libraries & Learning Sciences Faculty and Staff Publications

ChatGPT and other generative AIs are raising important issues in information literacy that are unique, but not without precedent. The rise of Google and Wikipedia were accompanied by similar paradigm shifts. Exploring librarians’ early responses to these tools allows us to use that history to inform our approach to generative AIs. This exploratory study looks at social media posts, including email listservs, as well as sampling the professional literature to see librarians’ reactions in terms of impacts on the profession and the resulting pedagogical approaches to teaching information literacy in the early days of Google and Wikipedia.

Modeling Apparent Pb Loss In Zircon U-Pb Geochronology, Glenn R. Sharman, Matthew A. Malkowski

Geosciences Faculty Publications and Presentations

The loss of radiogenic Pb from zircon is known to be a major factor that can cause inaccuracy in the U–Pb geochronological system; hence, there is a need to better characterize the distribution of Pb loss in natural samples. Treatment of zircon by chemical abrasion (CA) has become standard practice in isotope dilution–thermal ionization mass spectrometry (ID-TIMS), but CA is much less commonly employed prior to in situ analysis via laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) or secondary ionization mass spectrometry (SIMS). Differentiating the effects of low levels of Pb loss in Phanerozoic zircon with relatively low-precision in situ U–Pb …

Intrinsic Lipid Curvature And Bilayer Elasticity As Regulators Of Channel Function: A Comparative Single-Molecule Study, Mohammad Ashrafuzzaman, Roger E. Koeppe Ii, Olaf S. Andersen

Chemistry & Biochemistry Faculty Publications and Presentations

Perturbations in bilayer material properties (thickness, lipid intrinsic curvature and elastic moduli) modulate the free energy difference between different membrane protein conformations, thereby leading to changes in the conformational preferences of bilayer-spanning proteins. To further explore the relative importance of curvature and elasticity in determining the changes in bilayer properties that underlie the modulation of channel function, we investigated how the micelle-forming amphiphiles Triton X-100, reduced Triton X-100 and the H_II lipid phase promoter capsaicin modulate the function of alamethicin and gramicidin channels. Whether the amphiphile-induced changes in intrinsic curvature were negative or positive, amphiphile addition increased gramicidin channel …

Thermal-Induced Buoyant Water Jet Discharge Under Shallow Coastal Water Conditions, Amir Bordbar, Yong Ming Dai, Simone Michele, Ola Zawalna-Geer, Zhengwei Chen, Salah A. Faroughi, Yeaw Chu Lee

School of Engineering, Computing and Mathematics

A novel discharge dispersion model is developed to simulate the complex three-dimensional flow behaviour of thermal-induced buoyant water jets under current-wave coexisting conditions. The model solved the governing fluid flow and energy equations for two immiscible and incompressible phases (water and air) which were weakly coupled by applying the Boberbeck-Boussinesq approximation. Different turbulence models, such as k−ε multiphase, k-ω SST, k-ω SST-multiphase, k-ω SST-stable, and realizable k−ε were applied. Extensive verification of the model's performance is conducted by comparing the developed model results against a diverse range of analytical and experimental data. First, a series of simulations are carried out …

The Mini-Cog: A Community Screening Tool For Dementia In Indonesia, Yuda Turana, Nicolas Farina, Imelda Theresia, Tara Puspitarini Sani, Ika Suswanti, Fasihah Irfani Fitri, Emiliano Albanese, Adelina Comas-Herrera, Martin Knapp, Sube Banerjee

Peninsula Medical School

Background: Early detection of dementia enables more effective planning and can enable access to treatment and support. The Mini-Cog is a widely used screening instrument in Indonesia; however, this instrument has never undergone a translation and cultural adaptation process. Currently, there is no data on how accurate the tool is against diagnostic criteria, particularly in low-education. Methods: Embedded within the community-based dementia prevalence study was the Strengthening Responses to Dementia in Developing Countries (STRiDE) project; older adults (aged ≥ 65 years) were randomly recruited from sites in Jakarta and North Sumatra, Indonesia. All participants were asked to complete the Mini-Cog …

Mixed Debris Interaction With Obstacle Array Under Extreme Flood Conditions, Piyali Chowdhury, Indigo Jaie Fredericks, Jesus Castaño Alvarez, Matthew Clark, Ravindra Jayaratne, J. J. Wijetunge, Alison Raby, Paul Taylor

School of Engineering, Computing and Mathematics

This investigation explores the interactions of different shaped debris with an array of obstacles under subcritical flow conditions, representative of a flood associated with a storm surge or tsunami. Panels, blocks and cylinders were used in a flow channel, as analogues for house panels, cars/containers and trees respectively, whilst some tests used a mix of debris. The backwater effect due to the blockage caused by the obstacles was most (least) significant for panels (cylinders). There was some evidence that smaller key log types and higher flow rates led to smaller dams. It was also evident that key logs formed at …

Nature-Based Approaches: A Mixed Methods Study Of Facilitators And Barriers To Implementation In Camhs, Siobhan B. Mitchell, Beth Chapman, Rachel Hayes, Hélène Bonnici, Hazel Banks, Silvana Mareva, Rebecca Hardwick

Peninsula Medical School

Background: There is growing evidence that spending time with or in nature can be beneficial for health and wellbeing. Emerging evidence suggests potential benefits for staff and service users in healthcare settings, yet little is known about how to put Nature-based approaches (NBAs) into practice within the Child and Adolescent Mental Health Services (CAMHS) setting. The CAMHS Goes Wild project in Southwest England aimed to explore the implementation of NBAs within CAMHS, examining staff attitudes and understanding to identify potential benefits and challenges through a mixed methods study. Methods: The study involved three phases of data collection: an online survey …

Guidelines For Protecting And Promoting Decapod Crustacean Welfare In Research, Mark Briffa

School of Biological and Marine Sciences

The decapod order contains ~15,000 species, including crabs, lobsters, crayfish, prawns, and shrimps. The idea that these animals might experience pain was long dismissed because they were thought to respond to noxious stimuli and tissue damage purely by nociceptive reflex—a position questioned by Sherwin (2001). Later experimental studies demonstrated that their responses were complex, long-lasting, and largely consistent with criteria for pain that had been produced initially for vertebrates (Elwood 2019). While the nature and extent of potential sentience in decapods remains an active area of research, these animals were recently recognized as sentient for the purposes of UK law, …

Preoperative Aerobic Fitness And Perioperative Outcomes In Patients Undergoing Cystectomy Before And After Implementation Of A National Lockdown, Nicholas Tetlow, Amy Dewar, Pietro Arina, Melanie Tan, Ashwin N. Sridhar, John D. Kelly, Nishkantha Arulkumaran, Robert C.M. Stephens, Daniel S. Martin, Suneetha R. Moonesinghe, John Whittle

Peninsula Medical School

Background: Lower fitness is a predictor of adverse outcomes after radical cystectomy. Lockdown measures during the COVID-19 pandemic affected daily physical activity. We hypothesised that lockdown during the pandemic was associated with a reduction in preoperative aerobic fitness and an increase in postoperative complications in patients undergoing radical cystectomy. Methods: We reviewed routine preoperative cardiopulmonary exercise testing (CPET) data collected prior to the pandemic (September 2018 to March 2020) and after lockdown (March 2020 to July 2021) in patients undergoing radical cystectomy. Differences in CPET variables, Postoperative Morbidity Survey (POMS) data, and length of hospital stay were compared. Results: We …

Perioperative Oxygenation—What's The Stress?, Joseph Larvin, Mark Edwards, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey

Peninsula Medical School

Oxygen is the most used drug in anaesthesia. Despite such widespread use, optimal perioperative oxygen administration remains highly controversial because of concerns about the competing harms of both hyperoxia and hypoxia. Notwithstanding a Cochrane review concluding that routinely administering a fractional inspired oxygen concentration (FiO₂) >0.6 intraoperatively might increase postoperative morbidity and mortality, the World Health Organization (WHO) currently recommends all anaesthetised patients receive 0.8 FiO₂ during and immediately after surgery to reduce surgical site infections. Results from the largest trial available at the time of these two reviews (suggesting long-term survival may be worse with high …

Covid And Mental Health In People With Intellectual Disability, Rohit Shankar

Peninsula Medical School

No abstract provided.

The Impact Of Area-Level Socioeconomic Status In Childhood On Mental Health In Adolescence And Adulthood: A Prospective Birth Cohort Study In Aotearoa New Zealand, Bingyu Deng, Geraldine F.H. Mcleod, Joseph Boden, Clive E. Sabel, Malcolm Campbell, Phoebe Eggleton, Matthew Hobbs

School of Geography, Earth and Environmental Sciences

Mental health conditions pose a significant public health challenge, and low area-level socioeconomic status (SES) is a potentially important upstream determinant. Childhood exposure might have influences on later-life mental health. This study, utilises data from the Christchurch Health and Development Study birth cohort, examining the impact of area-level SES trajectories in childhood (from birth to age 16) on mental health at age 16 and from age 18–40 years. Findings revealed some associations between distinct SES trajectories and mental health. The study underscores the importance of using a spatial lifecourse epidemiology framework to understand long-term environmental impacts on later-life health.

Balancing Energy Transition: Assessing Decent Living Standards And Future Energy Demand In The Global South, Souran Chatterjee

School of Geography, Earth and Environmental Sciences

Achieving low energy demand in buildings is crucial in climate change mitigation. In the Global South, however, reducing the energy demand blanketly is not advisable due to critical gaps in access to the basic services supporting Decent Living Standards (DLS). Current energy demand scenarios mostly overlook achievement of DLS. Furthermore, model limitations in representing distributional aspects hinder modelling future energy demands to meet DLS. Supported by new evidence from a set of detailed sectoral and integrated assessment models, this research contributes to bridging this gap by exploring future trends in DLS achievement and linkages with energy demand in the Global …

Hermit Crabs As Model Species For Investigating The Behavioural Responses To Pollution, Mark Briffa, Gareth Arnott, Jörg D. Hardege

School of Biological and Marine Sciences

Human impacts on the environment affect organisms at all levels of biological organisation and ultimately can change their phenotype. Over time, phenotypic change may arise due to selection but individual phenotypes are also subject to change via genotype × environment interactions. In animals, behaviour is the most flexible aspect of phenotype, and hence the most liable to change across environmental gradients including exposure to pollution. Here we review current knowledge on the impacts of pollution, broadly defined to include the release of substances, energy, and the effects of carbon emissions, on the behaviour of a highly studied group, the globally …

Co-Producing Ethics Guidelines Together With People With Learning Disabilities, Mary Bottomley, Jodie Bradley, Lisa Clark, Bryan Collis, Bojana Daw Srdanovic, Victoria Farnsworth, Annie Ferguson, Dan Goodley, Andrew Fox, Nikita K. Hayden, Charlotte Lawthom, Rebecca Lawthom, Claudia Magwood, Robert Mclean, Ian Middleton, Alison Owen, Matty Prothero, Simon Rice, Simon Richards, Katherine Runswick-Cole, Kelly Scargill, Rohit Shankar, Toni Ann Wood

Peninsula Medical School

Background: We are a research team of clinical, academic and advocacy-based researchers with and without learning disabilities, working on the Humanising Healthcare (for people with learning disabilities) project. The project is dedicated to finding and sharing healthcare practices that enhance the lives of people with learning disabilities. As part of our ethics applications to access National Health Service study sites for fieldwork, we worked together to write guiding principles for co-producing research ethics with researchers with learning disabilities. In this paper, we introduce these Participatory Ethics Good Practice Guidelines and reflect on our collaboration. Methods: We reflect on developing the …