Digital Commons Network^™

Citrulline And Adi-Peg20 Reduce Inflammation In A Juvenile Porcine Model Of Acute Endotoxemia, Caitlin Vonderohe, Barbara Stoll, Inka Didelija, Trung Nguyen, Mahmoud Mohammad, Yava Jones-Hall, Miguel A Cruz, Juan Marini, Douglas Burrin

Faculty, Staff and Students Publications

BACKGROUND: Arginine is a conditionally essential amino acid that is depleted in critically ill or surgical patients. In pediatric and adult patients, sepsis results in an arginine-deficient state, and the depletion of plasma arginine is associated with greater mortality. However, direct supplementation of arginine can result in the excessive production of nitric oxide (NO), which can contribute to the hypotension and macrovascular hypo-reactivity observed in septic shock. Pegylated arginine deiminase (ADI-PEG20, pegargiminase) reduces plasma arginine and generates citrulline that can be transported intracellularly to generate local arginine and NO, without resulting in hypotension, while maintaining microvascular patency. The objective of …

Ice-Marginal Volcanic Sequence In Iceland Found On A Nondescript Gradual Hillslope: An Unexpected Record Of Ice Thickness Late In Deglaciation, Audrey R. Putnam, Kristen L. Siebach, Candice C. Bedford, Sarah L. Simpson, Michael T. Thorpe, Joseph J. Tamborski

OES Faculty Publications

Volcanism increases when glaciers melt because isostatic rebound during deglaciation decreases the pressure on the mantle, which enhances decompression melting. Anthropogenic climate change is now causing ice sheets and valley glaciers to melt around the world and this deglaciation could stimulate volcanic activity and associated hazards in Iceland, Antarctica, Alaska, and Patagonia. However, current model predictions for volcanic activity associated with anthropogenic deglaciation in Iceland are poorly constrained, in part due to uncertainties in past volcanic output over time compared to ice sheet arrangements. Further work specifically characterizing glaciovolcanic and ice-marginal volcanoes in Iceland is needed to reconstruct volcanic output …

A Proxy System Modeling Approach To Combining Tree-Ring And Sediment-Based Paleotempestological Records, Elizabeth J. Wallace, Sylvia Dee, Joshua Bregy, Kerry A. Emanuel

OES Faculty Publications

The short and biased observational record of tropical cyclones (TCs) limits scientific understanding of how these destructive storms respond to climate forcing. Paleohurricane records use natural archives (tree rings, coarse-grained sediment) to reconstruct TC properties (frequency and intensity of rainfall, wind) over the past few hundreds to thousands of years. However, different sensitivities and sampling biases in the various paleohurricane proxies restrict our ability to compile these records into regional or basin-scale TC estimates. Here we test how well pseudo tree-ring records of paleohurricanes capture TC rainfall and occurrence. Using a large set of statistically downscaled storms forced with the …

Contrasting Nitrogen Dynamics Across The Mid-Atlantic Bight Shelfbreak Front: Insights From Nitrate Dual Isotopes And Nitrifier Gene Abundance, Yifan Zhu, Margaret R. Mulholland, Corday R. Selden, Dennis J. Mcgillicuddy Jr., Josie Mottram, P. Dreux Chappell, Weifang Gordon Zhang, Julie Granger, Katherine E. Crider, Meredith G. Meyer, Peter W. Bernhardt, Hilde Oliver, Sophie Clayton

OES Faculty Publications

Observations and model studies suggest that front dynamics can enhance phytoplankton productivity. This study tested whether frontal systems also increase the abundance of nitrifying microbes and nitrogen recycling during repeat sampling transects across the Mid‐Atlantic Bight shelfbreak in July 2019. We measured ammonium concentrations, nitrate dual isotopes (δ¹⁵N, δ¹⁸O), and ammonia monooxygenase subunit A (amoA) genes of ammonia‐oxidizing archaea (AOA) and bacteria (AOB). In subsurface shelf waters, ammonium concentrations exceeded 2 μmol L⁻¹, due to a temporary imbalance in regeneration from sinking particles and subsequent nitrification. The inverse correlation between nitrate δ^{15 …}

Widespread Crab Burrows Enhance Greenhouse Gas Emissions From Coastal Blue Carbon Ecosystems, Kai Xiao, Yuchen Wu, Feng Pan, Yingrong Huang, Hebo Peng, Meiqing Lu, Yan Zhang, Hailong Li, Yan Zheng, Chunmiao Zheng, Yan Liu, Nengwan Chen, Leilei Xiao, Guangxuan Han, Yasong Li, Pei Xin, Ruili Li, Bochao Xu, Faming Wang, Joseph J. Tamborski, Alicia M. Wilson, Daniel M. Alongi, Isaac R. Santos

OES Faculty Publications

Fiddler crabs, as coastal ecosystem engineers, play a crucial role in enhancing biodiversity and accelerating the flow of material and energy. Here we show how widespread crab burrows modify the carbon sequestration capacity of different habitats across a large climatic gradient. The process of crab burrowing results in the reallocation of sediment organic carbon and humus. Crab burrows can increase more greenhouse gases emissions compared to the sediment matrix (CO2: by 17-30%; CH4: by 49-141%). Straightforward calculations indicate that these increased emissions could offset 35-134% of sediment carbon burial in these two ecosystems. This research highlights the complex interactions between …

Contemporary Functional Coronary Angiography: An Update, Josiah Bennett, Sanjay Chandrasekhar, Edward Woods, Patrick Mclean, Noah Newman, Brett Montelaro, Hafeez Ul Hassan Virk, Mahboob Alam, Samin K Sharma, Hani Jned, Muzamil Khawaja, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Functional coronary angiography (FCA) is a novel modality for assessing the physiology of coronary lesions, going beyond anatomical visualization by traditional coronary angiography. FCA incorporates indices like fractional flow reserve (FFR) and instantaneous wave-free ratio (IFR), which utilize pressure measurements across coronary stenoses to evaluate hemodynamic impacts and to guide revascularization strategies. In this review, we present traditional and evolving modalities and uses of FCA. We will also evaluate the existing evidence and discuss the applicability of FCA in various clinical scenarios. Finally, we provide insight into emerging evidence, current challenges, and future directions in FCA.

Sex-Specific Outcomes Of Lbbap Versus Biventricular Pacing: Results From I-Clas, Faiz A Subzposh, Parikshit S Sharma, Óscar Cano, Shunmuga Sundaram Ponnusamy, Bengt Herweg, Francesco Zanon, Marek Jastrzebski, Jiangang Zou, Mihail G Chelu, Kevin Vernooy, Zachary I Whinnett, Girish M Nair, Manuel Molina-Lerma, Karol Curila, Kenneth A Ellenbogen, Pugazhendhi Vijayaraman

Faculty, Staff and Students Publications

Background: Cardiac resynchronization therapy (CRT) using biventricular pacing (BVP) has been associated with greater clinical improvement in women than men. Recently, left bundle branch area pacing (LBBAP) has been shown to be an alternative form of CRT.

Objectives: The purpose of this study was to investigate sex-specific outcomes for death and heart failure events in a large, international, multicenter, cohort of patients undergoing CRT with BVP or LBBAP.

Methods: In this international study of 1,778 patients (575 female and 1203 male), sex-specific survival analysis was performed to compare the effect of LBBAP-CRT relative to BVP-CRT on the combined endpoint of …

Optical Coherence Elastography Measures The Biomechanical Properties Of The Ex Vivo Porcine Cornea After Lasik, Achuth Nair, Fernando Zvietcovich, Manmohan Singh, Mitchell P Weikert, Salavat R Aglyamov, Kirill V Larin

Faculty, Staff and Students Publications

SIGNIFICANCE: The biomechanical impact of refractive surgery has long been an area of investigation. Changes to the cornea structure cause alterations to its mechanical integrity, but few studies have examined its specific mechanical impact.

AIM To quantify how the biomechanical properties of the cornea are altered by laser assisted in situ keratomileusis (LASIK) using optical coherence elastography (OCE) in ex vivo porcine corneas.

APPROACH: Three OCE techniques, wave-based air-coupled ultrasound (ACUS) OCE, heartbeat (Hb) OCE, and compression OCE were used to measure the mechanical properties of paired porcine corneas, where one eye of the pair was left untreated, and the …

The Utility Of Software-Detected Non-Invasive Tear Break-Up In Comparison To Fluorescein Tear Break-Up Measurements, Stephen C Pflugfelder, Yasushi Kikukawa, Shin Tanaka, Takuya Kosugi

Faculty, Staff and Students Publications

PURPOSE: The purpose of this study is to characterize and discuss the difference between software-detected non-invasive tear break-up time (NIBUT) and the traditional clinical method of fluorescein break-up time (FBUT).

METHODS: Tear interferometry with the KOWA DR-1α (Kowa, Japan) and a standardized comprehensive ocular surface/tear evaluation were performed in 307 eyes. Software-detected NIBUT in the KOWA DR-1α images and the investigator-detected FBUT were compared.

RESULTS: Software-detected NIBUT was significantly shorter than investigator-measured FBUT. NIBUT was 3.1 ± 2.5 s (mean ± SD), whereas FBUT was 4.8 ± 3.0 s. This difference was due to three different patterns or conditions: a …

Trpv4 Affects Visual Signals In Photoreceptors And Rod Bipolar Cells, Ye Long, Maxim Kozhemyakin, Samuel M Wu, Ji-Jie Pang

Faculty, Staff and Students Publications

INTRODUCTION: Mechanical sensitive channels expressed in mammalian retinas are effectors of elevated pressure stresses, but it is unclear how their activation affects visual function in pressure-related retinal disorders.

METHODS: This study investigated the role of the transient potential channel vanilloid TRPV4 in photoreceptors and rod bipolar cells (RBCs) with immunohistochemistry, confocal microscopy, electroretinography (ERG), and patch-clamp techniques.

RESULTS: TRPV4 immunoreactivity (IR) was found in the outer segments of photoreceptors, dendrites and somas of PKCα-positive RBCs and other BCs, plexiform layers, and retinal ganglion cells (RGCs) in wild-type mice. TRPV4-IR was largely diminished in the retinas of homozygous TRPV4 transgenic mice. …

Evaluating One-Week Post-Casting Alignment Checks And Surgical Intervention Rates In Pediatric Type Iia Supracondylar Humeral Fractures, Jason Z Amaral, Rebecca J Schultz, Benjamin M Martin, Jacob P Scioscia, Basel Touban, Barkha N Chhabra, Kelly Cline, Scott D Mckay

Faculty, Staff and Students Publications

BACKGROUND: This study aims to determine the rate of surgical intervention in children with type IIA supracondylar humerus fractures (SCHF) following routine post-casting radiographic assessment. We hypothesized that no cases would convert to operative management following one-week post-casting alignment assessments.

METHODS: This single-center retrospective study focused on pediatric patients diagnosed with type IIA SCHF from 2019 to 2022. Patients were treated with initial long arm cast immobilization, followed by a one-week post-casting radiographic alignment check in cast. Fractures were graded in consensus using the Wilkins-Modified Gartland classification system by three fellowship-trained pediatric orthopaedic surgeons. Demographics, casting details, follow-up dates, and …

Patient Questions Surrounding Posterior Nasal Nerve Ablation For Chronic Rhinitis, Daniel Gorelik, Samuel E Razmi, Robert Kenneth Sims, Aatin K Dhanda, Masayoshi Takashima, Ella S Brissett, Nicholas R Rowan, Michael T Yim, Najm Khan, Meha G Fox, Omar G Ahmed

Faculty, Staff and Students Publications

OBJECTIVE: In-office ablation of the posterior nasal nerve (PNN) has emerged as an effective treatment option for chronic rhinitis patients. This study explored questions patients commonly search online regarding this therapy and the quality of content available.

STUDY DESIGN: A retrospective analysis of online search criteria and sources was performed with subsequent analysis of results.

SETTING: Search and data acquisition was in September of 2023.

METHODS: Most common search terms related to cryotherapy and radiofrequency neurolysis of the PNN were identified with associated People Also Ask (PAA) questions. Questions were categorized and organized into subtopics and sources evaluated using readability …

Relationship Between Clinical Measures Of Hearing And Clinical Measures Of Vestibular Function, Helen S Cohen, Haleh Sangi-Haghpeykar, J Connor Sullivan, Nathan Silver, Liam D Ferreira, Jen Li Dong, Alex D Sweeney, Angela S Peng

Faculty, Staff and Students Publications

PURPOSE: Patients often have basic audiometry (BA) but not objective diagnostic tests of the vestibular system (VNG) when complaining of symptoms of a vestibular disorder. The relationship of BA results to VNG results is unknown. This study sought to determine if BA scores are related to impaired VNG scores.

MATERIALS AND METHODS: We reviewed electronic medical records at a tertiary care center, for patients seen between 2015 and 2021 who had had both a BA and a VNG (n = 651). BA subtests were pure tone averages, word recognition, and tympanogram. VNG subtests were cervical vestibular evoked myogenic potentials, Dix-Hallpike …

Garbage In ≠ Garbage Out: Exploring Gan Resilience To Image Training Set Degradations, Nicholas Crino, Bruce A. Cox, Nathan B. Gaw

Faculty Publications

Generative Adversarial Networks (GANs) have received immense attention in recent years due to their ability to capture complex, high-dimensional data distributions without the need for extensive labeling. Since their conception in 2014, a wide array of GAN variants have been proposed featuring alternative architectures, optimizers, and loss functions with the goal of improving performance and training stability. This manuscript focuses on quantifying the resilience of a GAN architecture to specific modes of image degradation. We conduct systematic experimentation to empirically determine the effects of 10 fundamental image degradation modes, applied to the training image dataset, on the Fréchet inception distance …

2024-2025 4-H Ag Ambassador Interest Packet, Hannah Majewski

UNH Cooperative Extension

No abstract provided.

4-H And Open Horse Show, Diane Dugray

UNH Cooperative Extension

No abstract provided.

Therapeutic Ultrasound: Providing An Educational Intervention On Best Practice Techniques And Their Implications, Michael Kjellerson

Health Nutrition and Exercise Science

BACKGROUND: Therapeutic ultrasound is a modality that is commonly used in the treatment of musculoskeletal injuries by healthcare professionals throughout the world for both its thermal and non-thermal effects. PURPOSE: This study used an in-person or virtual asynchronous educational intervention to educate and demonstrate best practice techniques to practicing athletic trainers while surveying their usage, perception, confidence, and knowledge regarding the modality. METHODS: Thirty-one athletic trainers completed the educational intervention, including 13 who participated in the in-person session and 18 in the virtual asynchronous session. Qualtrics based surveys occurred immediately before and after each educational intervention and four weeks following …

Operationalising Progressive Ideas About Property: Resilient Property, Scale, And Systemic Compromise, Marc L. Roark, Lorna Fox O'Mahony

Articles, Chapters in Books and Other Contributions to Scholarly Works

Property theory is at a crossroads. In recent decades, scholars seeking to advance progressive ideas about property have embraced ‘Progressive Property’ theories that seek to advance the goals of social justice and the common good, offering a vital counter-weight to utilitarian and neo-conservative accounts of property. Progressive Property theories seek to correct an imbalance in American property discourse which—across the temporal scale—has sustained a range of narratives and normative commitments, but which has veered towards extreme acquisitive individualism and the rhetoric of property absolutism since the 1970s. The idea that individual property rights are not absolute but defined by the …

The Effects Of An Acute Session Of Blood Flow Restriction Exercise On Autonomic Modulation, Andrew Garner

Health Nutrition and Exercise Science

PURPOSE: How an acute training session of blood flow restriction (BFR) exercise affects autonomic modulation during a unilateral knee extension exercise. METHODS: Fourteen physically active males completed three different sessions while performing a unilateral knee extension exercise. The dependent variables measured: Heart rate variability (HRV), muscle oxygen saturation (SmO2), and rating of perceived exertion (RPE). Repeated measures ANOVAs were used to analyze HRV and SmO2 data. A paired t-test was used to analyze RPE data. RESULTS: Significant time-effect differences were found in lnRMSSD, lnHF, and lnLF at baseline to 15 minutes post-exercise and 15 to 30 minutes post-exercise (P < 0.05). Time and group-effect differences were significant in SmO2%, oxygenated, and deoxygenated hemoglobin in the vastus lateralis (VL) muscle in BFR compared to control (P < 0.05). RPE increased when BFR was applied (P < 0.05). CONCLUSION: Exercise protocol may need to be altered to show autonomic modulation changes.

Associations Of Antioxidant Consumption From Food And Supplement Sources On Cognitive Function In Older Adults, Kelly Knoll

Health Nutrition and Exercise Science

Oxidative stress, the imbalance of prooxidants and antioxidants, has been recognized as a possible risk factor for cognitive impairment. We postulate that increased dietary antioxidant consumption could help preserve cognitive function during aging. Dietary intake and cognitive function of 50 adults aged ≥65-years (66% women; aged 71.5±5.1 years) was assessed using Cronometer, an electronic nutrition analysis application, and the Saint Louis University Mental Status examination. The fisher’s exact test (p < 0.01) identified a significantly lower percentage of cognitive dysfunction (31.6%; 6 of 19 participants) among participants that met the Recommended Daily Allowances (RDAs) for the antioxidants, vitamin C, vitamin E, selenium, and manganese, and a higher percentage of cognitive dysfunction among those that did not meet the antioxidant RDAs (74.2%; 23 of 31 participants). However, mean cognitive scores differed insignificantly between those meeting RDAs (26.2 ±4.2 points) and those that did not (24.9 ±2.9 points; p = 0.07).

Using Traditional Foods And Food Preservation Of The Great Plains American Indians To Address Food Insecurity And Chronic Disease In The Great Plains Tribal Regions, Eliza Johnson

Health Nutrition and Exercise Science

The American Indian (AI) population has a history that goes back at least 10,000 years on the land of the Great Plains. Their traditional foods helped them survive on a land that no other human had ever stepped foot on; however, traditional foods and food ways were erased during colonial occupation of tribal lands and the relocation of tribes to resource poor reservations. The purpose of this project is to evaluate how traditional AI foods and preservation of these foods can be used to address the high rates of food insecurity and chronic disease in the AI population. The project …

The Missile People: A Cold War Public Memory, Shane Engeland

History, Philosophy, and Religious Studies

Disrupting the horizon with a startling physical presence on the flat North Dakota prairie, the remains of the Stanley R. Mickelsen Safeguard Complex are the physical remnants of a decisive stage of the Cold War. The complex was part radar array, part computing marvel, and part nuclear launch control platform that represented a significant federal investment in rural North Dakota. Together, these pieces created the pinnacle of the Pentagon’s efforts to create an effective antiballistic missile system. The local memories attached to the complex contrast with general perceptions of the Cold War. Memories of friendship and community are common when …

Unfit: Eugenics On The Northern Great Plains, Levi Magnuson

History, Philosophy, and Religious Studies

The early twenty-first century saw the emergence of the eugenics movement in the United States, which culminated in the sterilization of people with mental or physical disabilities. State institutions across the country were weaponized against these citizens due to the perception that they were “unfit” to be parents. Recent scholarship on the topic has sought to uncover this history. This study seeks to uncover this past in both North and South Dakota as well as offer an alternative avenue for examining the topic with Canton Hiawatha Asylum for Insane Indians. Both states provide instances that confirm the current scholarship on …

Leveraging Genomics And Transcriptomics For Gene Discovery In Dry Pea, Josephine Johnson

Genomics and Bioinformatics

Over the past two decades, there has been a significant increase in the utilization of DNA marker-based mapping studies to genetically map and further improve complex quantitative traits. A major caveat of this approach is that genetic mapping of the underlying genes conferring target phenotypes is challenging often due to the extent of long-range linkage disequilibrium (LD) in the genome, particularly in self-pollinated crops. Recent technologies allow us to examine expression-phenotype associations using transcriptome-wide association studies (TWAS) which is independently affected by LD, unlike in the case of genetic markers. This is of greatest utility in species where linkage disequilibrium …

An Exploratory Study Of A Peer Mentoring Program For High School Students With Disabilities, Jordan Bentz

Human Development and Family Science

Many students with disabilities are isolated from general education classrooms and are restricted in the social opportunities that are available to them. With the shift toward more inclusive education settings, these students are given the chance to develop alongside their general education peers. The present study analyzed a peer mentoring program that partnered students with disabilities (i.e., mentees) and students without disabilities (i.e., mentors) with the goal of promoting inclusion at a high school. The study included a set of focus groups and surveys. The four focus groups included past mentors, teachers, and administrators who answered questions about their perception …

Implementing Industry 4.0: A Study Of Socio-Technical Readiness Among Manufacturers In Minnesota And North Dakota, Katherine Roth

Industrial and Manufacturing Engineering

The implementation of Industry 4.0 has become increasingly prevalent in the manufacturing industry since its inception. With the introduction of these newer technologies, changes in personnel and organizational structures occur. The purposeful joint optimization of social and technical factors of organizations is imperative to the successful adoption of Industry 4.0. Thus, the socio-technical system theory addresses a holistic design of human, technology, and organization subsystems of the manufacturing process and their interdependencies. This dissertation investigates the progress made towards implementing Industry 4.0 by small, medium, and large manufacturers in Minnesota and North Dakota. The outcomes of two surveys conducted among …

De Novo Missense Variants In Zbtb47 Are Associated With Developmental Delays, Hypotonia, Seizures, Gait Abnormalities, And Variable Movement Abnormalities, Scott K Ward, Alexandrea Wadley, Chun-Hui Anne Tsai, Paul J Benke, Lisa Emrick, Kristen Fisher, Kimberly M Houck, Hongzheng Dai, Undiagnosed Diseases Network, Maria J Guillen Sacoto, William Craigen, Kimberly Glaser, David R Murdock, Luis Rohena, Karin E M Diderich, Hennie T Bruggenwirth, Brendan Lee, Carlos Bacino, Lindsay C Burrage, Jill A Rosenfeld

Faculty, Staff and Students Publications

The collection of known genetic etiologies of neurodevelopmental disorders continues to increase, including several syndromes associated with defects in zinc finger protein transcription factors (ZNFs) that vary in clinical severity from mild learning disabilities and developmental delay to refractory seizures and severe autism spectrum disorder. Here we describe a new neurodevelopmental disorder associated with variants in ZBTB47 (also known as ZNF651), which encodes zinc finger and BTB domain-containing protein 47. Exome sequencing (ES) was performed for five unrelated patients with neurodevelopmental disorders. All five patients are heterozygous for a de novo missense variant in ZBTB47, with p.(Glu680Gly) (c.2039A>G) detected …

Research Participants' Perspectives On Precision Diagnostics For Alzheimer's Disease, Hadley Stevens Smith, Jill O Robinson, Ariel Levchenko, Stacey Pereira, Belen Pascual, Kathleen Bradbury, Victoria Arbones, Jamie Fong, Joshua M Shulman, Amy L Mcguire, Joseph Masdeu

Faculty, Staff and Students Publications

BACKGROUND: Understanding research participants' responses to learning Alzheimer's disease (AD) risk information is important to inform clinical implementation of precision diagnostics given rapid advances in disease modifying therapies.

OBJECTIVE: We assessed participants' perspectives on the meaning of their amyloid positron emission tomography (PET) imaging results for their health, self-efficacy to understand their results, psychological impact of learning their results, experience receiving their results from the clinical team, and interest in genetic testing for AD risk.

METHODS: We surveyed individuals who were being clinically evaluated for AD and received PET imaging six weeks after the return of results. We analyzed responses …

Parkinson's Disease And Other Alzheimer's Disease And Related Dementia Pathologies And The Progression Of Parkinsonism In Older Adults, Aron S Buchman, Lei Yu, Shahram Oveisgharan, Andrea R Zammit, Tianhao Wang, Joshua M Shulman, Veronique Vanderhorst, Sukrit Nag, David A Bennett

Faculty, Staff and Students Publications

BACKGROUND: The interrelationship of parkinsonism, Parkinson's disease (PD) and other Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD) pathologies is unclear.

OBJECTIVE: We examined the progression of parkinsonian signs in adults with and without parkinsonism, and their underlying brain pathologies.

METHODS: Annual parkinsonian signs were based on a modified Unified Parkinson's Disease Rating Scale. We used linear mixed effects models to compare the progression of parkinsonian signs in 3 groups categorized based on all available clinical evaluations: Group1 (never parkinsonism or clinical PD), Group2 (ever parkinsonism, but never clinical PD), Group3 (ever clinical PD). In decedents, we examined …

Neuronal Ablation Of Ghsr Mitigates Diet-Induced Depression And Memory Impairment Via Ampk-Autophagy Signaling-Mediated Inflammation, Hongying Wang, Zheng Shen, Chia-Shan Wu, Pengfei Ji, Ji Yeon Noh, Cédric G Geoffroy, Sunja Kim, David Threadgill, Jianrong Li, Yu Zhou, Xiaoqiu Xiao, Hui Zheng, Yuxiang Sun

Faculty, Staff and Students Publications

Obesity is associated with chronic inflammation in the central nervous system (CNS), and neuroinflammation has been shown to have detrimental effects on mood and cognition. The growth hormone secretagogue receptor (GHSR), the biologically relevant receptor of the orexigenic hormone ghrelin, is primarily expressed in the brain. Our previous study showed that neuronal GHSR deletion prevents high-fat diet-induced obesity (DIO). Here, we investigated the effect of neuronal GHSR deletion on emotional and cognitive functions in DIO. The neuron-specific GHSR-deficient mice exhibited reduced depression and improved spatial memory compared to littermate controls under DIO. We further examined the cortex and hippocampus, the …