Digital Commons Network^™

The Delegation Doctrine, Jonathan H. Adler

Faculty Publications

Despite the focus on the Court’s recent major questions cases, signs of an emergent delegation doctrine can also be found elsewhere. Most significantly, seeds of a delegation doctrine have been planted within the Court’s Chevron jurisprudence. The Court’s increased reluctance to grant Chevron deference to administrative agencies--and its insistence that courts first conclude that interpretive authority has been delegated before deferring to any agency interpretation—rests on the same core premise as the Court’s recent major questions doctrine decisions. It also suggests that the “new” major questions doctrine is not as new as it might seem, but rather a logical outgrowth …

Naming, Expressive Interests, And The Law: The Implications Of Governmental Form Design, Laura A. Heymann

Faculty Publications

The design of governmental forms can result in restrictions on the ability of individuals to submit truthful personal naming choices, such as when a form field has character limitations or does not accept diacritics. In some instances, form design operationalizes government policy. But in other instances, form design can itself create law by limiting the ability to submit accurate names on the front end. Awareness of the legal implications of form design is critically important. A more inclusive and accurate approach toward the legal documentation of naming choices means that forms should adapt to people, not the other way around.

Patent Term Tailoring, Sarah R. Wasserman Rajec

Faculty Publications

Patent rights are designed to encourage innovation with both the promise of a patent and with its expiration. Currently, patent term lasts from issuance until twenty years from the application date, with minor exceptions. The patent term is limited so that rewards for past invention do not overly hinder future progress. Although the goal is laudable, a uniform patent term is a blunt instrument to achieve such a nuanced balance. Historically, the patent system was not averse to tailoring terms through, for example, individually granted extensions to undercompensated inventors or term curtailment when a foreign patent holder failed to “work” …

Synthesis And Evaluation Of 5-(Heteroarylmethylene)Hydantoins As Glycogen Synthase Kinase-3Β Inhibitors, Nicholas O. Schneider, Keandra Gilreath, Daniel J. Burkett, Martin St. Maurice, William A. Donaldson

Chemistry Faculty Research and Publications

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase which plays a center role in the phosphorylation of a wide variety of proteins, generally leading to their inactivation. As such, GSK-3 is viewed as a therapeutic target. An ever-increasing number of small organic molecule inhibitors of GSK-3 have been reported. Phenylmethylene hydantoins are known to exhibit a wide range of inhibitory activities including for GSK-3β. A family of fourteen 2-heterocycle substituted methylene hydantoins (14, 17–29) were prepared and evaluated for the inhibition of GSK-3β at 25 μM. The IC50 values of five of these compounds was determined; the two best inhibitors …

Efficient Synthesis Of Thiazole-Fused Bisnoralcohol Derivatives As Potential Therapeutic Agents, Subrata Roy, Hansa Raj Kc, Sanjay Adhikary, Alexander N. Erickson, Mohammad Abrar Alam

Chemistry Faculty Research and Publications

Thiazole derivatives are known for a wide range of therapeutic properties. Bisnoralcohol is an inexpensive natural product obtained by the biodegradation of sterols. This article describes an efficient synthesis of a library of thiazole-fused bisnoralcohol derivatives. These novel compounds have been studied for their antineoplastic and antibacterial properties, which led to the discovery of hit compounds with therapeutic potential. The antibacterial compound is noncytotoxic and nonhemolytic against cancer cell lines and sheep red blood cells, respectively. Several of the antineoplastic compounds showed activity against human cancer cell lines with growth inhibition at submicromolar concentration.

Mechanism Of Action Of Kl-50, A Candidate Imidazotetrazine For The Treatment Of Drug-Resistant Brain Cancers, Eric D. Huseman, Anna Lo, Olga Fedorova, James L. Elia, Susan E. Gueble, Kingson Lin, Ranjini K. Sundaram, Jooneseok Oh, Jinchan Liu, Fabian Menges, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Victor S. Batista, Jason M. Crawford, Anna M. Pyle, Ranjit S. Bindra, Seth B. Herzon

Chemistry Faculty Research and Publications

Aberrant DNA repair is a hallmark of cancer, and many tumors display reduced DNA repair capacities that sensitize them to genotoxins. Here, we demonstrate that the differential DNA repair capacities of healthy and transformed tissue may be exploited to obtain highly selective chemotherapies. We show that the novel N3-(2-fluoroethyl)imidazotetrazine “KL-50” is a selective toxin toward tumors that lack the DNA repair protein O⁶-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O⁶-alkylguanine lesions. We establish that KL-50 generates DNA interstrand cross-links (ICLs) by a multistep process comprising DNA alkylation to generate an O⁶-(2-fluoroethyl)guanine (O⁶FEtG) …

Terra-Lsd1 Phase Separation Promotes R-Loop Formation For Telomere Maintenance In Alt Cancer Cells, Nicholas J. Reiter

Chemistry Faculty Research and Publications

The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway. Here we report that TERRA contributes to ALT via interacting with the lysine-specific demethylase 1A (LSD1 or KDM1A). We show that LSD1 localizes to ALT telomeres in a TERRA dependent manner and LSD1 function in ALT is largely independent of its demethylase activity. Instead, LSD1 promotes TERRA recruitment to ALT telomeres via RNA binding. In addition, LSD1 and TERRA undergo phase separation, driven by interactions between the RNA binding properties of LSD1 and the G-quadruplex structure of TERRA. Importantly, the …

Mirabile Dictu: The Bryn Mawr College Library Newsletter 27 (2024), Bryn Mawr College Library

Mirabile Dictu: Newsletter of the Bryn Mawr College Libraries

No abstract provided.

Electrospun Pt-Tio₂ Nanofibers Doped With Hpa For Catalytic Hydrodeoxygenation, Amos Taiswa, Randy L. Maglinao, Jessica M. Andriolo, Sandeep Kumar, Jack L. Skinner

Civil & Environmental Engineering Faculty Publications

Electrospinning is utilized to fabricate catalytic nanofiber scaffold for biocrude upgrading in hydrodeoxygenation (HDO) following computational studies suggesting the need for nano-catalysts for efficient HDO conversion and selectivity. Here, Pt-TiO₂ nanofibers are fabricated through electrospinning, followed by wet impregnation with a heteropoly acid (HPA), tungstosilicic acid. Intensive heat treatments were incorporated during and after processes to obtain a HPA doped Pt-TiO₂ nano-catalyst. Catalytic HDO was performed in a batch reactor with phenol as the raw biocrude dissolved in hexadecane. The HPA doped Pt-TiO₂ catalyst demonstrated promising HDO performance of 37.2% conversion and a 78.9% selectivity to oxygen …

Compound Flooding Hazards Due To Storm Surge And Pluvial Flow In A Low-Gradient Coastal Region, Sunghoon Han, Navid Tahvildari

Civil & Environmental Engineering Faculty Publications

Flood risk analyses often focus on a single flooding source, typically storm surge or rainfall-driven flooding, depending on the predominant threat. However, hurricanes frequently cause compound flooding through significant storm surges accompanied by heavy rainfall. This study employs a hydrodynamic model based on Delft3D-Flexible Mesh that couples flow, waves, and rainfall-driven flow to simulate five historical tropical cyclones in Virginia's southeast coastal region. These storms produced varying intensities of storm surge and rainfall in the study area. Model simulations, incorporating rainfall through a rain-on-grid approach, account for the dynamic interaction between storm tides, and pluvial flow and enable the definition …

The Game, The Players, And The Board, Bruce E. Boyden

Faculty Publications

Christopher Seaman and Thuan Tran’s fascinating article, Intellectual Property and Tabletop Games, raises important questions about the role of intellectual property in developing and distributing innovative products. The market for tabletop games, Seaman and Tran argue, is able to sustain a high level of creativity at a high up-front cost, all while protected by some but not all of the IP rights that other industries’ outputs receive. Is that evidence of IP’s necessity or its superfluousness? In this Response, I argue that the answer is a little bit of both. Whereas prior scholarship has shown the lack of an …

Riemannian Frameworks For The Harmonization Of Resting-State Functional Mri Scans, Nicolas Honnorat, Sudha Seshadri, Ron Killiany, John Blangero, David C. Glahn, Peter T. Fox, Mohamad Habes

School of Medicine Publications

Magnetic Resonance Imaging provides unprecedented images of the brain. Unfortunately, scanners and acquisition protocols can significantly impact MRI scans. The development of statistical methods able to reduce this variability without altering the relevant information in the scans, often coined harmonization methods, has been the topic of an increasing research effort supported by the recent growth of publicly available neuroimaging data sets and new possibilities for combining them to achieve greater statistical power. In this work, we focus on the challenges specifically raised by the harmonization of resting-state functional MRI scans. We propose to harmonize resting-state fMRI scans by reducing the …

Targeting Of Oncogenic Aaa-Atpase Trip13 Reduces Progression Of Pancreatic Ductal Adenocarcinoma, Farrukh Afaq, Sumit Agarwal, Prachi Bajpai, Sameer Al Diffalha, Hyung-Gyoon Kim, Shajan Peter, Moh'd Khushman, Subhash Chauhan, Priyabrata Mukherjee, Sooryanarayana Varambally, Upender Manne

School of Medicine Publications

Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression, but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the expression, functional role, and mechanism of action of TRIP13 in PDAC. We further examined the efficacy of TRIP13 inhibitor, DCZ0415, alone or in combination with gemcitabine on malignant phenotypes, tumor progression, and immune response. We found that TRIP13 was overexpressed in human PDACs relative to corresponding normal pancreatic tissues. TRIP13 knockdown or treatment of PDAC cells with DCZ0415 reduced proliferation and colony formation, and induced G2/M cell cycle arrest and apoptosis. Additionally, TRIP13 knockdown …

Facilitating Mathematics And Computer Science Connections: A Cross-Curricular Approach, Kimberly E. Beck, Jessica F. Shumway, Umar Shehzad, Jody Clarke-Midura, Mimi Recker

Publications

In the United States, school curricula are often created and taught with distinct boundaries between disciplines. This division between curricular areas may serve as a hindrance to students' long-term learning and their ability to generalize. In contrast, cross-curricular pedagogy provides a way for students to think beyond the classroom walls and make important connections across disciplines. The purpose of this paper is a theoretical reflection on our use of Expansive Framing in our design of lessons across learning environments within the school. We provide a narrative account of our early work in using this theoretical framework to co-plan and enact …

Negotiating Inherent Asymmetries Of Co-Design: A Case Of Integrative Elementary Mathematics And Computer Science Instruction, Victor R. Lee, Stephanie Robillard, Mimi Recker, Jody Clarke-Midura, Jessica Shumway

Publications

Collaborative design, or “co-design”, is a term that has gained popularity in educational research and design communities, including those working with K-12 educators. While more groups are identifying with and pursuing co-design, much remains to be understood about how to structure the work within given different constraints, circumstances, and resources available to different parties. We propose understanding co-design as having inherent asymmetries and that structuring co-design work patterns involves negotiation of those asymmetries. Through a case of an elementary computer science and math integration research-practice partnership, we share ways that those asymmetries are both intentionally softened and leveraged at different …

Using Student Experience Reports As A Window For Teacher Reflections On Inquiry Science Instructional Practices, Jessie Nixon, Mimi Recker

Publications

This paper examines how student experience reports, collected as exit tickets, can be leveraged during professional learning to support science teachers’ understanding of their students and inform future classroom practices. Our analysis frames exit ticket data as a boundary object, which bridges across researchers’, teachers’, and students’ perspectives of the learning environment. During two successive professional learning activities, teachers examined and reflected upon their students’ exit ticket data. A thematic analysis of teachers’ discourse during these activities distilled two themes. The first theme surfaced how exit data helped teachers form new views about their students’ emerging science identities; the second …

Low Energy Availability, Disordered Eating, Exercise Dependence, Injury Prevalence, And Fueling Habits In Female Crossfit® Participants, Alyssum Reno-Smith

Dissertations

Disordered eating (DE) is primarily observed in endurance athletes and sports with aesthetics emphases. The prevalence of DE in resistance trained individuals, particularly CrossFit^®, is not well understood. CrossFit® promotes a culture encouraging strong, athletic, or muscular bodies, and both CrossFit® and endurance athletes aim to achieve a low body fat percentage to improve performance. This may lead to body dissatisfaction, exercise dependence (EXD), and/or DE behaviors, which may contribute to Relative Energy Deficiency in Sport (REDs). This cross-sectional study investigated DE prevalence and relationship with EXD risk, body dissatisfaction, and fueling habits in female CrossFit® only (CO) …

Comparison Of Enhanced And Standard Data Sheets On Treatment Fidelity And Data Collection For Tact Training, Mary Halbur, Jessi Reidy, Tiffany Kodak, Landon Scott Cowan, Michael Harman

Psychology Faculty Research and Publications

Specifically designed data sheets have been recommended to assist with the fidelity of implementation of treatment procedures. The present study extended previous research (e.g., Bottini et al. Behavior Analysis: Research & Practice 21(2), 140–152, 2021; LeBlanc et al. Behavior Analysis in Practice 13(1), 53–62, 2020) by comparing an enhanced data sheet (i.e., the inclusion of randomized targets, prompts for treatment components of securing attending and reinforcement) to a standard data sheet (i.e., targets not preset, no prompts for treatment components) on the fidelity of tact training of features. Ten behavior therapists participated in each condition (n = …

Sexual Minority Behavioral Health Outcomes: The Role Of Identity Authenticity And Self-Regulation., Zane B. Ballard, Debra L. Oswald

Psychology Faculty Research and Publications

No abstract provided.

Genetic Risk For Alzheimer’S Disease Alters Perceived Executive Dysfunction In Cognitively Healthy Middle-Aged And Older Adults, Sarah A. Evans, Elizabeth R. Paitel, Riya Bhasin, Kristy A. Nielson

Psychology Faculty Research and Publications

Background:

Subjective cognitive complaints (SCC) may be an early indicator of future cognitive decline. However, findings comparing SCC and objective cognitive performance have varied, particularly in the memory domain. Even less well established is the relationship between subjective and objective complaints in non-amnestic domains, such as in executive functioning, despite evidence indicating very early changes in these domains. Moreover, particularly early changes in both amnestic and non-amnestic domains are apparent in those carrying the Apolipoprotein-E ɛ4 allele, a primary genetic risk for Alzheimer’s disease (AD).

Objective:

This study investigated the role of the ɛ4 allele in the consistency between subjective …

Editorial: Insights In Neurocognitive Aging And Behavior: 2022, Kristy A. Nielson, Annalena Venneri, Shin Murakami

Psychology Faculty Research and Publications

No abstract provided.

Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification By The Enigma Ptsd Consortium, Benjamin Suarez-Jimenez, Amit Lazarov, Sigal Zilcha-Mano, Xi Zhu, Yoojean Kim, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Background

Intrusive traumatic re-experiencing domain (ITRED) was recently introduced as a novel perspective on posttraumatic psychopathology, proposing to focus research of posttraumatic stress disorder (PTSD) on the unique symptoms of intrusive and involuntary re-experiencing of the trauma, namely, intrusive memories, nightmares, and flashbacks. The aim of the present study was to explore ITRED from a neural network connectivity connectivity perspective.

Methods

Data were collected from 9 sites taking part in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) PTSD Consortium (n = 584) and included itemized PTSD symptom scores and resting-state functional connectivity (rsFC) data. We assessed the …

Listening To Families: Qualitative Analysis Of Family Perspectives On The Impact Of Participating In A Complex Care Program, Jessica L. Schnell, Astrida S. Kaugars, Sarah Johaningsmeir, Sara K. Quates, K. Jane Lee

Psychology Faculty Research and Publications

Background

Complex Care Programs (CCPs) provide care for children with medical complexity (CMC). The broad impact of CCP participation on families is unknown. This study sought to elucidate what families value about participation in a CCP and what additional benefit families hope CCPs will provide.

Methods

Surveys from families of CMC in a CCP were collected over the course of two years. Responses were summarized for two fixed response satisfaction questions. Qualitative responses to two open-ended questions exploring CCP value were analyzed using content analysis.

Results

Most families (95% and 97%) were somewhat or very satisfied with the CCP. All …

Team Situation Awareness, Cohesion, And Autonomic Synchrony, Stephen J. Guastello, Cooper Bednarczyk, Ryan Hagan, Camerhon Johnson, Laura Marscisek, Laura M. Mcguigan, Anthony F. Peressini

Psychology Faculty Research and Publications

Objective

This study evaluated the causal relationships among situation awareness (SA), cohesion, and autonomic synchrony (SE) within teams. SA is often a team effort and should be more accurate in better-functioning teams.

Background

Cohesive teams perform better overall, although the relationship appears reciprocal; the relationship to SA has not been considered previously. SEis a collective neurocognitive activity that has been connected to team coordination, communication, and performance in some circumstances.

Method

In this experiment, 71 undergraduates, organized into 16 teams, played two matches of a first-person shooter computer game and completed self-report measures of cohesion …

Smaller Total And Subregional Cerebellar Volumes In Posttraumatic Stress Disorder: A Mega-Analysis By The Enigma-Pgc Ptsd Workgroup, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to …

Exploring The Association Between Structural Racism And Mental Health: Geospatial And Machine Learning Analysis, Fahimeh Mohebbi, Amir Masoud Forati, Lucas Torres, Terri A. Deroon-Cassini, Jennifer Harris, Carissa W. Tomas, John R. Mantsch, Rina Ghose

Psychology Faculty Research and Publications

Background:

Structural racism produces mental health disparities. While studies have examined the impact of individual factors such as poverty and education, the collective contribution of these elements, as manifestations of structural racism, has been less explored. Milwaukee County, Wisconsin, with its racial and socioeconomic diversity, provides a unique context for this multifactorial investigation.

Objective:

This research aimed to delineate the association between structural racism and mental health disparities in Milwaukee County, using a combination of geospatial and deep learning techniques. We used secondary data sets where all data were aggregated and anonymized before being released by federal agencies.

Methods:

We …

Cross-Temporal Hierarchical Forecast Reconciliation Of Natural Gas Demand, Colin O. Quinn, George F. Corliss, Richard J. Povinelli

Electrical and Computer Engineering Faculty Research and Publications

Local natural gas distribution companies (LDCs) require accurate demand forecasts across various time periods, geographic regions, and customer class hierarchies. Achieving coherent forecasts across these hierarchies is challenging but crucial for optimal decision making, resource allocation, and operational efficiency. This work introduces a method that structures the gas distribution system into cross-temporal hierarchies to produce accurate and coherent forecasts. We apply our method to a case study involving three operational regions, forecasting at different geographical levels and analyzing both hourly and daily frequencies. Trained on five years of data and tested on one year, our model achieves a 10% reduction …

Something For Every Kind Of Learner: Students’ Perceptions Of An Educational Recommender Study Tool, Cherie Noteboom, Alicia Mcnett

Research & Publications

The field of education has the potential to better facilitate student learning by employing educational recommender systems that adapt the learning process to the needs of individual learners. There is a lack of research that ties educational theory to the design and implementation of these systems. In this research, the design science methodology is employed to advocate for an educational recommender framework with a theoretical base in self-regulated learning. This paper focuses on the qualitative evaluation of this approach to gain insights on students’ perceptions of the resulting recommender when deployed to assist students when studying for an upcoming exam. …

Exploring Large Language Models For Ontology Learning, Olga Perera, Jun Liu

Research & Publications

Ontology Learning aims to facilitate automatic or semi-automatic ontology development based on machine learning techniques in context of big data. Recent evolution of technology has introduced Generative Artificial Intelligence (AI) capable of creating new data, extracting insights from the existing data, and generating coherent texts from various inputs. This ability supports analysis of text data, providing insights and annotations that reduce human effort. This study explores the emerging field of Generative AI, specifically, Large Language Models for ontology learning. We conducted a survey of the current state of Generative AI research with focus on applicability and efficacy for ontology development …

Critical Success Factors For Bi Systems Implementation And Delivery: A Systematic Literature Review, Badr Harfoush, Omar F. El-Gayar, Noura Mansoura

Research & Publications

Despite the widespread acquisition of business intelligence (BI) systems, their implementation has not always been successful. This study examines the critical success factors (CSFs) that impact the implementation of BI systems in organizations. The systematic literature review follows the guidelines of Kitchenham and Charter’s research that was published in 2007. A total of 93 articles published between 2011 and 2021 were analyzed for CSF related to BI systems implementation and delivery. The study identified 56 CSFs linked to organization empowerment & operations, 52 CSFs related to system implementation, and 28 CSFs associated with user enablement. The study found a paucity …