Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (27148)
- Social and Behavioral Sciences (20652)
- Arts and Humanities (19481)
- Education (14340)
- Physical Sciences and Mathematics (13989)
-
- Life Sciences (13574)
- Law (10959)
- Medical Specialties (9452)
- Engineering (9242)
- Medical Sciences (6554)
- Business (4754)
- Public Health (4166)
- Higher Education (4150)
- Psychology (4147)
- History (4100)
- Computer Sciences (3700)
- Creative Writing (3529)
- Sociology (3487)
- Earth Sciences (3165)
- Religion (3064)
- Public Affairs, Public Policy and Public Administration (2969)
- Plant Sciences (2949)
- Oncology (2771)
- Diseases (2656)
- Biomedical Informatics (2632)
- English Language and Literature (2578)
- Nursing (2501)
- Environmental Sciences (2411)
- Bioinformatics (2314)
- Art and Design (2264)
- Institution
-
- University of South Florida (34951)
- The Texas Medical Center Library (5988)
- University of Kentucky (3628)
- University of Montana (3027)
- Chulalongkorn University (2432)
-
- University of Texas at Arlington (2237)
- University of Nebraska - Lincoln (2066)
- Liberty University (2028)
- New Jersey Institute of Technology (1977)
- Walden University (1867)
- Utah State University (1860)
- University of New Hampshire (1810)
- University of Alabama at Birmingham (1764)
- Washington University School of Medicine (1712)
- Brigham Young University (1701)
- University of Texas Rio Grande Valley (1678)
- Ateneo de Manila University (1609)
- Sigma Theta Tau International Honor Society of Nursing (1478)
- University of Arkansas, Fayetteville (1430)
- University of New Mexico (1417)
- Kennesaw State University (1355)
- University of South Carolina (1315)
- University of Plymouth (1311)
- Purdue University (1304)
- Louisiana State University (1287)
- Singapore Management University (1283)
- University of Mississippi (1280)
- Universitas Indonesia (1279)
- Georgia Southern University (1248)
- Villanova University Charles Widger School of Law (1220)
- Keyword
-
- Humans (5709)
- Female (2846)
- Male (2488)
- Animals (1726)
- Adult (1501)
-
- ICTS (Institute of Clinical and Translational Sciences) (1420)
- Middle Aged (1399)
- UAB (1352)
- English (1274)
- Aged (1190)
- Mice (1167)
- Undergraduate (1051)
- Education (1027)
- Literary (971)
- Litmag (969)
- COVID-19 (931)
- Child (764)
- United States (744)
- Mental health (709)
- Machine learning (708)
- Adolescent (671)
- Artificial intelligence (638)
- Condolence notes (548)
- Higher education (524)
- Climate change (514)
- Retrospective Studies (492)
- Sustainability (484)
- Leadership (477)
- Young Adult (462)
- Poetry (433)
- Publication
-
- The Auk (22791)
- Faculty, Staff and Student Publications (3560)
- Theses and Dissertations (3290)
- North American Bird Bander (2833)
- Eastern Bird Banding Association News (2766)
-
- University of Montana Course Syllabi, 2021-2025 (2283)
- Faculty, Staff and Students Publications (1890)
- IGC Proceedings (1977-2023) (1881)
- Journal of Raptor Research (1843)
- Walden Dissertations and Doctoral Studies (1780)
- Faculty Publications (1774)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (1768)
- 2020-Current year OA Pubs (1690)
- Doctoral Dissertations and Projects (1268)
- Defensive Publications Series (1136)
- Dissertations (1101)
- 2024 Decisions (1098)
- Electronic Theses and Dissertations (1091)
- Marine Ornithology (1089)
- Research outputs 2022 to 2026 (1037)
- Faculty Scholarship (821)
- Kritika Kultura (813)
- Theses (764)
- McKinney and Milam Family Papers (700)
- PoemMemoirStory (literary magazine) (694)
- Leadership Connection (682)
- Ontario Birds (673)
- Honors Theses (655)
- Articles (619)
- Meacham-Carter Papers (616)
- Publication Type
Articles 188731 - 188760 of 193011
Full-Text Articles in Entire DC Network
Fp-24-03 A Decade Of Change In Cohabitation Across Age Groups: 2012 & 2022, Wendy D. Manning, Jaden Loo
Fp-24-03 A Decade Of Change In Cohabitation Across Age Groups: 2012 & 2022, Wendy D. Manning, Jaden Loo
National Center for Family and Marriage Research Family Profiles
No abstract provided.
Fp-24-06 Married Same-Sex And Different Sex Couples: A Demographic Portrait, Krista K. Westrick-Payne, Wendy D. Manning
Fp-24-06 Married Same-Sex And Different Sex Couples: A Demographic Portrait, Krista K. Westrick-Payne, Wendy D. Manning
National Center for Family and Marriage Research Family Profiles
No abstract provided.
Fp-24-11 Divorce: More Than A Century Of Change, 1900-2022, Jaden Loo
Fp-24-11 Divorce: More Than A Century Of Change, 1900-2022, Jaden Loo
National Center for Family and Marriage Research Family Profiles
Although the divorce rate in the United States increased throughout much of the twentieth century, it has declined in recent decades. Here we explore the variation in women’s rate of divorce and the proportion of ever-married women separated/divorced from 1900 to 2022 using National Vital Statistics, Decennial Census, and American Community Survey data. We then examine the proportion of currently separated/divorced among ever-married women from 1940 to 2022, disaggregating trends by race/ethnicity and educational attainment. This profile is an update to FP-20-22 and a companion profile to FP-24-10, which details variation in marriage trends over the last century.
Investigation Of The Essential Oil Constituents Of Pimenta Racemosa Aerial Parts And Evaluation Of Its Antiviral Activity Against Hsv 1 And 2, Fathia S. Elshaarawy, Mohamed I. S. Abdelhady, Wafaa Hamdy, Haitham A. Ibrahim
Investigation Of The Essential Oil Constituents Of Pimenta Racemosa Aerial Parts And Evaluation Of Its Antiviral Activity Against Hsv 1 And 2, Fathia S. Elshaarawy, Mohamed I. S. Abdelhady, Wafaa Hamdy, Haitham A. Ibrahim
Trends in advanced sciences and technology
Pimenta racemosa is a well-known plant used in traditional medicine to treat several ailments. Current pharmaceutical industries rely heavily on the discovery of secondary metabolites found in plants to aid in the development of novel drugs with potential biological activity. This study aimed to investigate the essential oil constituents of Pimenta racemose (Mill.) J. W. Moore aerial parts (leaves and small branches) and evaluate its antiviral activity. The essential oil was prepared by conventional hydro distillation method. The prepared oil was analyzed by GC/MS. Identification of the essential oil constituents was achieved by comparing retention indices (RI) relative to standard …
Impact Of Glottis Area On Airflow Dynamics In The Human Trachea Using A Simplified Stenosis Pipe Model, Amany M. Kamal, Momtaz Sedrak, Abouelmagd Abdelsamie
Impact Of Glottis Area On Airflow Dynamics In The Human Trachea Using A Simplified Stenosis Pipe Model, Amany M. Kamal, Momtaz Sedrak, Abouelmagd Abdelsamie
Trends in advanced sciences and technology
A complex transitional flow is produced in the larynx during air inhalation process, pivotal for fundamental comprehension and medical advancements in treatment methodologies. This study delves into the influence of the glottis region utilizing a simplified stenosis pipe geometry, examining two distinct cases: (1) the axisymmetric case and (2) the eccentric case. Reynolds-averaged Navier–Stokes equations with shear stress transport (SST) 𝑘 − 𝜔 turbulence model with intermittency transition activated with steady, Newtonian, and incompressible airflow have been used. The analysis underscores the significant impact of the eccentricity on the velocity by increasing 0.6% comparing with axisymmetric case, also particularly affecting …
Diabetic Insole Design Using Finite Element Analysis, Nora K. Yousef, Mohamed Tarek El-Wakad, Mohamed Ahmed Ali Eldosoky, Ahmed Mustafa Soliman
Diabetic Insole Design Using Finite Element Analysis, Nora K. Yousef, Mohamed Tarek El-Wakad, Mohamed Ahmed Ali Eldosoky, Ahmed Mustafa Soliman
Trends in advanced sciences and technology
Diabetic patients frequently face complications such as foot ulcers which are the primary cause of lower-limb amputation. Recent research has found that reducing plantar pressure can dramatically minimize the chance of developing a diabetic foot ulcer. Using orthopedic insoles can lead to reducing and redistributing pressure on the foot's sole. The purpose of this study was to develop a technique using Finite Element Analysis (FEA) for creating dedicated, low-cost insoles for diabetic patients to reduce maximal plantar pressure, and to rapidly refine designs and assess their effectiveness in meeting a predefined pressure threshold for foot offloading in diabetic neuropathic patients. …
Examining U.S. National Trends In Adult Mental Illness And Naturalistic Psychedelic Drug Use, Daniel Grossman
Examining U.S. National Trends In Adult Mental Illness And Naturalistic Psychedelic Drug Use, Daniel Grossman
All ETDs from UAB
Psychedelic drugs have gained prominent attention in recent years for their therapeutic potential in treating mental illness in clinical settings. Concurrently, population studies show increasing prevalence and notable demographic changes among naturalistic psychedelic users, as well as mixed associations between different types of naturalistic psychedelic use and mental health. However, despite this ongoing cultural shift, little is known about temporal changes in the mental health profiles of naturalistic psychedelic users at the population level. This thesis examined national trends in the association between past year naturalistic use of LSD, MDMA, and DMT/AMT/Foxy and past year mental illness among US adults, …
Erosion Of Trust In Healthcare Leadership: An Analysis Of Anomie And Social Exchange During The Covid-19 Pandemic, Ashleigh Allgood
Erosion Of Trust In Healthcare Leadership: An Analysis Of Anomie And Social Exchange During The Covid-19 Pandemic, Ashleigh Allgood
All ETDs from UAB
Background: The COVID-19 pandemic disrupted healthcare systems worldwide, posing profound challenges for healthcare professionals. This study examined how the pandemic affected healthcare workers' trust in their leaders, comparing the acute 2021 phase and more managed 2022 period. Objective: To investigate how healthcare workers' experiences of moral distress, organizational change, belongingness, and perceived organizational support influenced trust in supervisors and senior leaders across two pandemic phases. Methods: Anonymous survey data were analyzed from healthcare professionals at a Southeastern U.S. academic medical center in 2021 (n=2,991) and 2022 (n=2,581). Ordinal logistic regression examined relationships between trust and experiences of moral distress, discrimination, …
Insulin Responses, Diet Composition, And Fat Loss, Amanda Finn
Insulin Responses, Diet Composition, And Fat Loss, Amanda Finn
All ETDs from UAB
Some but not all studies show participants who have higher baseline insulin responses lose more weight on a low glycemic load compared to a high glycemic load diet. Most prior research tested the relationship between insulin and weight changes with only one insulin response variable, such as insulin from an orally or intravenously (IV) administered metabolic test. We tested whether insulin responses (IV or oral) predicted changes in body fat among participants undergoing diet-induced weight loss. This study was a secondary analysis of a clinical trial. In the parent study, participants were randomized to either a reduced carbohydrate (ReducedCHO) or …
Motor Development Of Individuals Referred For An Asd Evaluation, Timothy Gary Hilty
Motor Development Of Individuals Referred For An Asd Evaluation, Timothy Gary Hilty
All ETDs from UAB
Autism spectrum disorder (ASD) is neurodevelopmental disorder that affects 1 in 36 children. Fine motor skill delays and deficits are a common occurrence among autistic individuals. Fine motor delays tend to present in toddlerhood and deficits tend to persist into adulthood. However, fine motor skill delays and deficits are not a component of the diagnostic criteria for an ASD diagnosis. While fine motor differences between autistic and typically developing individuals are well established, it remains unclear if these differences exist between autistic individuals and those with other neurodevelopmental disorders and whether they provide additional insight into diagnosing ASD more accurately. …
Does Ceo Education Matter? The Relationship Between Doctoral-Educated Hospital Ceos And Organizational Performance, Kofi Ali Cash
Does Ceo Education Matter? The Relationship Between Doctoral-Educated Hospital Ceos And Organizational Performance, Kofi Ali Cash
All ETDs from UAB
One of the most pressing issues in healthcare strategic leadership research is identifying which hospital chief executive officer (CEO) characteristics possess a significant and favorable relationship to organizational performance. However, little is known about the relationship between hospitals led by doctoral-educated CEOs and organizational performance. This study adds to our knowledge by examining the relationship between doctoral-educated hospital CEOs and selected financial and patient safety outcomes. UET served as the theoretical framework and guided the examination of the relationship between the selected dependent and independent variables. This study’s population included 509 acute-care hospitals across nine states, requiring a minimum four-year …
Utilization Of Romosozumab During Covid-19 Pandemic Among U.S. Medicare Beneficiaries, Ye Liu
Utilization Of Romosozumab During Covid-19 Pandemic Among U.S. Medicare Beneficiaries, Ye Liu
All ETDs from UAB
Osteoporosis is increasingly recognized as a major public health issue in the aging U.S. population. Shortly after the licensure of romosozumab, an injectable medication indi-cated for women with postmenopausal osteoporosis at high risk of fracture administered by health care provider monthly, the COVID-19 pandemic broke out, which caused ma-jor disruptions to the delivery of health care across the nation. The pandemic dispropor-tionately affected minority and economically disadvantaged communities, exacerbating many pre-existing health disparities. Romosozumab has the highest dosing frequency among common injectable osteoporosis medications in the U.S. that require an office visit for injection, making romosozumab adherence more susceptible to …
Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter
Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter
All ETDs from UAB
Positron emission tomography (PET) imaging agents play a transformative role in personalized medicine through their application in disease diagnosis and immunotherapy monitoring, focusing on chemokine receptors, TH1-activated immune cells, and tuberculosis (TB) diagnostics. In immuno-oncology, accurately assessing TH1-activated immune cells in the tumor microenvironment (TME) is vital for evaluating cancer immunotherapy efficacy. Chemokine receptors, crucial in cellular signaling and inflammatory reactions, play a significant role in TH1 responses, thus serving as a potential area of interest in elucidating these anti-tumor responses. Through our work a novel CXCR3-targeting immunoPET probe, [89Zr]DFO-αCXCR3, was developed to detect and quantify these cells. This probe …
Titanium-45 Radiochemistry For The Development Of Pet Radiopharmaceuticals, Fnu Shefali
Titanium-45 Radiochemistry For The Development Of Pet Radiopharmaceuticals, Fnu Shefali
All ETDs from UAB
Imaging using nuclear medicine techniques has enabled non-invasive measurements of biomarkers for a wide range of diseases including cancer and neurodegenerative disorders. The production and characterization of new radioisotopes are crucial steps in designing radiopharmaceuticals for nuclear imaging applications. 45Ti is a novel radionuclide with desired physical characteristics for use in Positron Emission Tomography (PET) imaging. The half-life of 3.08 h is ideal for the imaging of small peptides. In addition, the 45Ti decay by positron emission (85 %) and a low mean positron energy (0.439 MeV) offers high spatial resolution. The production route of 45Ti is straightforward due to …
Crown Fatigue Resistance And Enamel Wear Of 3d Printed Resin Compared To Lithium Disilicate, Pranit Vasant Bora
Crown Fatigue Resistance And Enamel Wear Of 3d Printed Resin Compared To Lithium Disilicate, Pranit Vasant Bora
All ETDs from UAB
Purpose: The purpose of this study is to compare the wear characteristics and fatigue resistance of two dental crown materials: SprintRay Ceramic Crown, a 3D-printed resin material, and IPS™ e.Max CAD, a lithium disilicate material. Methods: This study evaluates wear and fatigue characteristics of dental crowns made from Ceramic Crown (SprintRay) and IPS e.max CAD LT (Ivoclar). For fatigue testing, custom fatigue devices were utilized to subject the crowns to cyclic loading, simulating occlusal forces. The specimens underwent 100,000 cycle intervals until 1.5 million cycles at a load of 40N of fatigue loading, with inspections conducted for signs of debonding, …
Phosphate Drives Pulmonary Inflammation Through Fgfr1, Erk, And Akt Signaling, Seth Bollenbecker
Phosphate Drives Pulmonary Inflammation Through Fgfr1, Erk, And Akt Signaling, Seth Bollenbecker
All ETDs from UAB
Chronic kidney disease (CKD) is characterized as irreversible progressive loss of renal function and affects over one tenth of the global population. Although CKD-associated comorbidities contribute significantly to its mortality, the lungs are often not considered. Lung diseases make up three of the top six leading causes of death worldwide and share many comorbidities with CKD. Clinical reports show that CKD patients are more likely to develop obstructive and restrictive lung diseases, but the mechanisms underlying this propensity for CKD-associated pulmonary complications are unknown. Hyperphosphatemia and associated elevations of fibroblast growth factor (FGF) 23, two of many consequences of reduced …
Teachers' Perspectives On The Impact Of Interactive Read Aloud Strategies For Comprehension Skills Of Saudi Kindergarten Students: A Mixed Method Study, Riham Alsultan
All ETDs from UAB
Reading comprehension is a very integral element of encouraging lifelong learning amongst kindergarten students. The main objective of this research is to investigate teachers’ perspectives on the effectiveness of interactive read-aloud (IRA) in improving reading comprehension skills amongst kindergarten students in Saudi Arabia. The study's overarching aim was to determine how interactive reading-aloud strategies employed by Saudi kindergarten teachers during interactive read-aloud time impact Saudi kindergarten students' overall comprehension skills through the perceptions of teachers regarding the effectiveness of these strategies. To achieve this objective, the researcher employed a mixed-method research design, a combination of both quantitative and qualitative strategies. …
Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang
Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang
All ETDs from UAB
This dissertation focuses on developing predictive modeling using data from two areas: clinical data and microbiome data. Compositional data in real life are mainly represented by relative proportions. With the advancement of next-generation sequencing (NGS) technology, researchers can now collect a large volume of metagenomic sequencing data, which is valuable for investigating associations between the microbiome and host diseases. Current methods for dealing with such data are either constrained by generalization or limited by application. In the first part, to address this, we propose Bayesian compositional generalized linear models for analyzing microbiome data (BCGLM). This model incorporates a structured regularized …
Access To And Service Utilization Of Alabama Medicaid's Section 1115 Demonstration Waiver Program, Sarah Lee Bowler
Access To And Service Utilization Of Alabama Medicaid's Section 1115 Demonstration Waiver Program, Sarah Lee Bowler
All ETDs from UAB
Background: Much research has been done investigating health disparities in the field of publicly-funding family planning. However, no longitudinal analysis has been conducted to examine the impact of Alabama Medicaid’s Section 1115 demonstration waiver on access to care, experience of barriers reported by enrollees, and repeat utilization of services. Methods: Medicaid enrollment and visit claims data were used to answer the questions related to access and service utilization. Annual Plan First survey data were used to investigate the experience of barriers to care among enrollees. For all three research questions, descriptive statistics were calculated, and linear probability models were used …
“Then Let Them Use Us Well”: How The Folger Edition Of Shakespeare’S Othello Limits Sexuality And Character Agency, Ann Elizabeth Mulherin
“Then Let Them Use Us Well”: How The Folger Edition Of Shakespeare’S Othello Limits Sexuality And Character Agency, Ann Elizabeth Mulherin
All ETDs from UAB
Since Shakespeare’s first folio and quartos were initially published directly after his death in the early seventeenth century, various editors have altered his plays for their desired goals. With this in mind, the primary focus of my thesis centers around the Updated Folger edition of The Tragedy of Othello, the Moor of Venice, edited by Barbara Mowat and Paul Werstine, which was published in 2017. The Folger edition repeatedly points out that they have tailored their rendition of Othello to allow modern audiences to understand Shakespeare’s language; they present the intention to accurately and helpfully gloss confusing, antiquated, or significant …
Using Hope To Cope: Chronic Stress, Religious Coping, And Masked Hypertension In African American Adults: The Jackson Heart Study, Miriam Miles
All ETDs from UAB
USING HOPE TO COPE: CHRONIC STRESS, RELIGIOUS COPING, AND MASKED HYPERTENSION IN AFRICAN AMERICAN ADULTS: THE JACKSON HEART STUDY ABSTRACT Chronic stress experienced at home or work has been associated with acute increases in blood pressure (BP) measured in the doctor’s office. Few data are available on the association of chronic stress with BP measured outside of the office setting. Religious coping, applying religious beliefs to adapt to stressful situations, and functional and structural social support may protect against MHT by promoting active coping behaviors and increasing emotional well-being. High levels of religious involvement and high social support have been …
Using The Social Ecological Model To Assess The Correlates Of Unprotected Sex Among African American Emerging Adults, Shirlacia S. Gray
Using The Social Ecological Model To Assess The Correlates Of Unprotected Sex Among African American Emerging Adults, Shirlacia S. Gray
All ETDs from UAB
USING THE SOCIAL ECOLOGICAL MODEL TO ASSESS THE CORRELATES OF UNPROTECTED SEX AMONG AFRICAN AMERICAN EMERGING ADULTS SHIRLACIA S. GRAY DEVELOPMENTAL PSYCHOLOGY ABSTRACT Background: The Centers for Disease Control and Prevention (CDC) reported that HIV diagnoses for Black/African American men and women are 8x and 15x higher than white individuals, respectively. While the social determinants of health largely influence HIV transmission rates, reducing risky behaviors can lower the risk for HIV. This current study used the Social Ecological Model to investigate correlates of unprotected sex. Methods: Participants were recruited through respondent-driven sampling. Participant's demographics (age, gender, years of education, financial …
Predicting Maximum Concentric And Eccentric Squat Strength From Maximum Isometric Squat Strength, Michael A. Dunn
Predicting Maximum Concentric And Eccentric Squat Strength From Maximum Isometric Squat Strength, Michael A. Dunn
All ETDs from UAB
Resistive squat exercise is a well-established technique to enhance the strength of muscles and bone of the back in humans. Such type of exercise could prove highly beneficial for individuals with pathological condition of the back such as osteoporosis. Notably, the rehabilitation programs aimed at strengthening the muscles and bone of the back require the knowledge of the patient’s one repetition maximum (1RM). Finding the 1RM squat value could lead to injury due to the higher weights involved. In addition, testing for 1RM could be not feasible in older populations or young population with chronic back conditions The isometric squat …
Effect Bioactive Material Have On Tooth Demineralization, Taillk Gomes
Effect Bioactive Material Have On Tooth Demineralization, Taillk Gomes
All ETDs from UAB
The objective of this in vitro study is to compare the inhibition of demineralization of root dentin caused by the presence of different restorative materials using Vickers Hardness (HV) test (microhardness) test and polarized light microscopy (PLM).
[Mis]Representing “India” And Other Colonial Territories In Donne’S Poetry: An Insight Into Colonialism’S Multifaceted Aspects, Urnisha Dutta
[Mis]Representing “India” And Other Colonial Territories In Donne’S Poetry: An Insight Into Colonialism’S Multifaceted Aspects, Urnisha Dutta
All ETDs from UAB
Colonial objects in Donne’s poems embrace multifaceted attributes, offering diverse reading perspectives. Considering their multifaceted aspects, it becomes impossible for a reader to ignore his poems’ interdisciplinary qualities. They often embrace philosophical, religious, political, and historical connotations. The colonial objects, appearing as “black” characters, silent women, or colonized territories in his poems, generate East-West binaries, Western subject consciousness, Eastern [mis]representations, world polarizations, and color contrasts. His female bodies’ misogynistic/sexual portrayal frequently ends in pulling up colonial references, associating their bodies with colonial landmasses. They often associate with his spiritual consciousness, complicating reading and textual interpretations. Critics thus cannot take a …
A Thematic Analysis Of Health Literacy And Education Disparities Regarding Medical Needs For Transgender Individuals, Rachel Mcmullen
A Thematic Analysis Of Health Literacy And Education Disparities Regarding Medical Needs For Transgender Individuals, Rachel Mcmullen
All ETDs from UAB
Transgender individuals experience many challenges within the healthcare system including discrimination, socioeconomic struggles, financial strains, a lack of educated healthcare providers, and a health system framework that makes it even more challenging for them to receive their medical needs (Korpaisarn and Safer). One contributing factor to this lack of education is that on average medical schools in the United States only spend approximately five hours total on the health needs related to lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals (Miller et al.). Another contributing factor is the stigma around LGBTQ individuals within the medical community. The stigma is concerning …
3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark
3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark
All ETDs from UAB
Ovarian cancer is the 5th leading cause of cancer deaths for women, primarily due to treatment resistant and/or recurrent disease. Most cases of ovarian cancer are not diagnosed until distant metastases have formed, which drastically reduces overall survival. The median age at diagnosis is 63 and most cases occur in patients who are peri- and post-menopausal. There is a critical gap between the clinical presentation of ovarian cancer and the preclinical models used to study the disease. Most preclinical in vivo investigations use mice who are between 6 and 12 weeks old, which corresponds to roughly a 20-year-old human. Therefore, …
Temporal And Epigenetic Mechanisms Underlying Dietary Phytochemicals In Breast Cancer Prevention, Andrew Brane
Temporal And Epigenetic Mechanisms Underlying Dietary Phytochemicals In Breast Cancer Prevention, Andrew Brane
All ETDs from UAB
Breast cancer (BC) is a widespread malignancy that, despite advancements in treatments and improvements in survival, had an estimated 297,790 new cases and 43,170 mortalities in 2023. With around 1 in every 8 women in the US expected to be diagnosed with BC at some point in their lives, the economic, societal, and healthcare burdens associated with this disease cannot be understated. Because of this, treatments and preventions that are affordable, efficacious, and easily administered are in high demand. Preventive therapies have shown great promise in reducing disease burden with relatively few serious side effects. BC prevention through the consumption …
The Association Between Cardiovascular Disease Risk And Fractures In Postmenopausal Women, Rafeka Hossain
The Association Between Cardiovascular Disease Risk And Fractures In Postmenopausal Women, Rafeka Hossain
All ETDs from UAB
Background: Fragility fractures pose a significant healthcare and economic burden in the United States. While age and bone mineral density (BMD) are the primary established risk factors for fragility fractures, the relationship between cardiovascular disease (CVD) and fractures remains underexplored. The primary objective of this analysis was to estimate the association of CVD risk with fractures in postmenopausal women. Methods: Utilizing 30 years of data from the WHI, Atherosclerotic Cardiovascular Disease (ASCVD) risk scores were computed using baseline age, race, systolic blood pressure, total cholesterol, high-density lipoprotein, diabetes, anti-hypertension medications, and smoking. Fracture outcomes encompassed any clinical fracture, major osteoporotic …
Comparative Enzymatic Analysis Of Different Isoforms Of Group A Streptococcal Bacteriophage H4489a Hyaluronidase, Urvi Prakash Rawal
Comparative Enzymatic Analysis Of Different Isoforms Of Group A Streptococcal Bacteriophage H4489a Hyaluronidase, Urvi Prakash Rawal
All ETDs from UAB
The Hyaluronate Lyase derived from Group A streptococcal bacteriophage H4489A gene (HylP) is known for cleaving the glycosidic bonds of high molecular weight hyaluronic acid (HMWHA), a substance often overexpressed in certain types of cancer cells. This enzymatic action produces HA oligosaccharides. Previous research, conducted by our team, has demonstrated that these oligosaccharides play a significant role in reducing the invasion, migration, and proliferation of breast cancer cells. This effect occurs through the disruption of Erk1/2 activation and RhoA expression. This bacteriophage hyaluronate lyase (HylP), a 40kDa protein, possesses a unique collagen-like sequence, consisting of 30 amino acids in a …