Digital Commons Network^™

Estrogen Receptor (Er) Alpha Regulatory Mechanisms And Therapeutic Strategies In Er+ Breast Cancer, Bianca A. Romo

Dartmouth College Ph.D Dissertations

Breast cancer is among the most frequently diagnosed cancers in the U.S. and is one of the leading causes of cancer-related mortalities, second to lung cancer. Estrogen receptor alpha-positive (ER+) breast cancer accounts for 2/3 of diagnosed cases. Patients diagnosed with this subtype of breast cancer typically undergo endocrine therapy that aims to mitigate the growth-promoting effects of estrogen/ER. While therapies are effective, 1/3 of patients will experience recurrence. To begin addressing this drug-resistant patient population, we investigated potential drug targets involved in response to treatment.

Coregulators have been implicated in the regulation of ER transcriptional activity and subsequently affecting …

Using Thin Films Of Phase-Change Material For Active Tuning Of Terahertz Waves Scattering On Dielectric Cylinders, Atilla Ozgur Cakmak, Evrim Colak, Andriy E. Serebryannikov

Open Access Publishing Support Funded Articles

The scattering of electromagnetic waves by isotropic dielectric cylinders can be dramatically modified by means of vanadium dioxide (VO₂) thin-film coatings. Efficient dynamic control of scattering is achieved due to the variations in material parameters realizable by means of external biasing. In this paper, we study the scattering of terahertz waves in a case where the coating shells are made of VO₂, a phase-change material, whose thin films may work rather as electromagnetic phase screens in the insulator material phase, but as lossy quasi-metallic components in the metallic material phase. The shells that uniformly cover the …

Biogenesis And Function Of Microglial Extracellular Vesicles In Neuroinflammation And Parkinson’S Disease, Karl E. Biggs

Dartmouth College Ph.D Dissertations

Microglia are subject to chronic proteinaceous and environmental stress during the progression of prevalent neurodegenerative diseases such as Parkinson’s Disease (PD). Chronic stress can activate the NLR family pyrin domain containing 3 (NLRP3) pattern recognition receptor resulting in the formation of the NLRP3 inflammasome, proinflammatory signaling, and pyroptotic cell death. A distinct subset of extracellular vesicles (EVs) are released from cells upon NLRP3 activation. We studied WT and Nlrp3^-/- primary microglia exposed to bacterial stimulating agents and alpha synuclein preformed fibrils (αsyn PFFs), which model Parkinson’s disease and associated synucleinopathies. We identified the NLRP3-dependent release of the endosome fate …

Democratic Accountability And Tax Enforcement, Joshua D. Blank, Leigh Osofsky

Faculty Publications

One of the most powerful charges that can be leveled against the IRS is that it is targeting taxpayers. Charges of political targeting have dogged the IRS for over a century, including in major controversies such as the alleged Tea Party auditing scandal in 2013. Commentators and scholars have long critiqued the IRS for focusing audit resources on some of the lowest-income Americans. And, most recently, a group of researchers estimated that the IRS audits Black taxpayers at a 2.9 to 4.7 times greater rate, as compared to non-Black taxpayers. In response, legislators demanded action, there was widespread public consternation, …

Reflections On Purpose And Professional Identity Formation, Harmony Decosimo

Faculty Publications

This essay explores how law students and lawyers develop, lose, or reorient their sense of purpose, using the author’s own trajectory through law school and practice to illustrate structural barriers—competition, lack of reflection, limited mentorship, and ideological homogeneity—that complicate identity formation. Identifying common lawyer archetypes whose work aligns differently with purpose, the author argues that legal education must make space for reflection, diverse viewpoints, and virtue-based development to enable students to integrate purpose meaningfully into their professional identities.

Debt, Race, And Physical Mobility, Kate Sablosky Elengold

Faculty Publications

Residents in every state in the United States can lose their driver’s license or car registration because they owe debt to the state. At least eleven million people across the United States suffer these debt-based driving restrictions at any given time. Because Americans overwhelmingly rely on personal automobiles for transportation, states, by controlling access to driver’s licenses and vehicle registrations, use debt policy to control where and how people travel. And because these laws disproportionately affect people of color, primarily Black people, this kind of regulation props up racial segregation in both location and opportunity. This Article’s first contribution is …

Masking Identity At Public Protests, Deborah R. Gerhardt

Faculty Publications

This Article will explore these issues to assist those seeking to enact constitutionally valid mask policies. To situate today’s mask regulation challenges in the context of American history, Part I reviews events that led to enactment of anti-mask laws many years ago. Part II explains when the First Amendment protects the right to wear a mask in public and when such permission may be lawfully abridged. The section explains the importance of analyzing whether wearing a mask in public is sufficiently expressive to merit First Amendment protection. When it is, the next challenge is to identify the constitutional standard for …

Against Associational Standing, Michael T. Morley, F. Andrew Hessick

Faculty Publications

This Article calls for the abandonment, or at least serious modification, of associational standing. Even without associational standing, groups may still sue to enforce their own rights. And they could continue to help vindicate their members’ rights by providing legal representation for member plaintiffs in individual or class action suits (filed anonymously, if necessary), covering members’ litigation costs, and providing expert witnesses and other guidance. In short, associational standing is a largely unnecessary deviation from both Article III’s injury-in-fact requirement and the fundamental principles underlying our justice system. Eliminating associational standing would not limit public law and other important collective …

Rethinking Tax Information: The Case For Quarterly 1099s, Kathleen Delaney Thomas

Faculty Publications

When an electricity provider wants customers to pay their bills monthly, it sends them a bill each month. Yet, this is not how the tax system works— at least not for independent contractors. Their taxes are due quarterly, but they receive a tax statement (Form 1099) only one time a year. It is up to the individual, then, to know when their taxes are due and how to pay them, and it is on that individual to estimate how much they owe each quarter. As a result, compliance for independent contractors—particularly for online platform workers—tends to be lacking. Failure to …

The Effects Of Exercise In Cognitive Function In Older Ad, Josephine Sagan

Honors Program Theses

No abstract provided.

A Comparison Between Two Schools Implementing Trauma-Informed Classroom Management, Maddie Steffen

Honors Program Theses

Traditional classroom management methods are ineffective with students who have or are experiencing trauma. Students will not physically be able to learn until they feel like they are in a safe space. A trauma-informed classroom provides students with a safe environment to facilitate learning. This approach to classroom management focuses on more than academics, but also the student’s well-being. It involves teachers trained in trauma awareness and strategies to help students cope with their emotions and engage in learning effectively. This project will study how two schools in a large urban public school district in the Midwest part of the …

The First Amendment To The Constitution, Associational Freedom, And The Future Of The Country: Alabama’S Direct Attack On The Existence Of The Naacp, Helen J. Knowles-Gardner

Seattle University Law Review

Sixty years ago, on Wednesday, April 8, 1964, Professor Harry Kalven, Jr., gave the second of three lectures at The Ohio State University College of Law Forum. These lectures were published two years later in a book entitled The Negro & the 1st Amendment. In the second lecture, Kalven distinguished between direct and indirect threats to the associational freedom of the National Association for the Advancement of Colored People (NAACP). Kalven categorized the 1958 decision in NAACP v. Alabama ex rel. Patterson as an indirect effort to control the NAACP.

With the benefit of material obtained from numerous archival sources, …

What Is In Your Tampon? Increasing Transparency In Menstrual Products, Elianna Spitzer

Seattle University Law Review

The average person who menstruates will bleed for an average of five days, every twenty-four to thirty-eight days, over several decades and could use thousands of disposable menstrual products in their lifetime. Menstrual products line retail shelves. They can be found in homes, bags, and bodies—but until 2021, manufacturers were not required to disclose the ingredients used to make these products to consumers at all. In fact, they still are not federally required to disclose menstrual product ingredients on product packaging. Instead, in recent years, changes to menstrual product labels have largely been the result of state legislation. In 2019, …

2024 Community-Based Care. Resident And Community Characteristics Report On Assisted Living, Residential Care, And Memory Care Communities, Ozcan Tunalilar, Sarah Dys, Yuliana Levchenko, Diana Jacoby, Minju Kim, Wafi Albalawi, Paula Carder

Institute on Aging Publications

This report marks the 10th anniversary of the Resident and Community Characteristics Report on Assisted Living (AL), Residential Care (RC), and Memory Care (MC) Communities as part of the Oregon Community Based Care project. This study includes rotating questions that focus on emerging areas of interest in the AL/RC/MC settings based on feedback from ODHS and interested parties alongside a core set of questions that are asked every year or every other year to allow comparisons over time. In this year’s study, we included information about various resident, community, and staff characteristics, including:

• Residents: sociodemographic characteristics (e.g., age, sex, …

Due Process Shaped By The Present Instead Of The Past: The Needed Reinvigoration Of A Lawrence Vision Of Due Process, Azor Cole

Seattle University Law Review

The recognition of unenumerated rights, rights implied from the text of the constitution, is a political battlefield waged through law with profound implications for all Americans. Generally, there have been two prongs for an inquiry into an unenumerated constitutional right under the Fourteenth Amendment. One is to ask whether the right to be found is objectively deeply rooted in this Nation’s history and tradition. The other is to ask whether the right to be found is fundamental to this Nation’s scheme of ordered liberty. The current Supreme Court has effectively done away with this present-day liberty analysis, saying it is …

Sneakers, The Shoes That Talk The Talk And Walk The Walk: How Jack Daniel’S Properties, Inc. V. Vip Products Left Its Footprint On Trademark Law And The Sneaker Industry, Nitya Tolani

Seattle University Law Review

As the fashion industry—including the sneaker industry housed within it—continues to go through the motions of collectively flocking out, and then collectively flocking again to the newest innovations in the world of wearables, the landscape of laws to protect and promote those innovations expands as well, mainly in the area of intellectual property law. Although copyright, trademark, and patent law can cover innovations in the fashion industry, this Note centers its analysis on trademark law. Trademark law has been through notable change in recent years because of the United States Supreme Court’s 2023 decision in Jack Daniel’s Properties, Inc. v. …

Prejudice Standards In Washington’S Appellate Courts, Andrew B. Van Winkle

Seattle University Law Review

When an appellate court finds an error to have occurred during a proceeding, the error is not yet subject to correction. In order to merit a remedy, the error must have been sufficiently prejudicial to the aggrieved party’s case. Drawing the line between correctable and non-correctable errors is not an easy task, for it often requires guessing at what was in the minds of jurors and trial judges. To cope with this task, courts have devised various rules and tests for deciding whether an error was likely prejudicial or not. These standards often go by names such as “harmless error,” …

Table Of Contents, Seattle University Law Review

Seattle University Law Review

Table of Contents

Suicidality Among Black Women: Considering Resiliency Within The Historic And Societal Context Of Risk, Samantha J. North

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Suicide is a global health challenge that has been historically understudied among Black women. The interpersonal-psychological theory of suicidality (IPTS) is a primary theory examined in suicidality; however, the three factors within the theory (lack of belongingness, perceived burdensomeness, and capability to die) focus on the individual. The purpose of the current study was to examine these factors in an expanded context of the historical and societal impact of oppression. A mixed methods Qualtrics study was administered to Black women who voluntarily completed the survey anonymously. Quantitatively, the study found significant differences between the impact of the IPTS factors on …

Report To The Presidents Of Church Of Christ Affiliated Colleges And Universities, Trace S. Hebert

Annual Reports to the Presidents of Church of Christ Affiliated Colleges and Universities

No abstract provided.

Organizational Ghosts: How “Ghostly Encounters” Enable Former Leaders To Influence Current Organizational Members, Jeffrey S. Bednar, Jacob A. Brown

Faculty Publications

Leadership research has assumed that leader group prototypicality enhances leadership influence during a leader’s tenure. Other leadership research has also assumed that leaders, especially founders, can transformtheir leadership influence into a legacy thatwill survive death and departure from the organization and continue to impact followers. However, to understand the historically embedded nature of leadership influence, it is critical to unpack how specific leaders can become group prototypes and influence followers after their departure. We address this opportunity by examining organizational ghosts—former organizational members who become the ideal prototype of an organization’s values and identity. Drawing on qualitative data from an …

Social Connections And Social Identity As A Basis For Learning And Support: Experiences Of Medical Students With Minoritised And Non-Minoritised Ethnic Identities, Stephanie Bull, Rohini Terry, Neil Rice, Daniele Carrieri, Mark Tarrant, Gerens Curnow

School of Psychology

Background: Social connections between medical students provide a key basis for learning and support. These connections, and associated social identity, may be patterned by ethnicity, and students often perform similarly academically to those they connect with. The mechanisms that underpin the formation of these connections and the role that they play are not fully understood. This study explored how medical students connect with each other, and the potential impact of this on their academic attainment and well-being, with a focus on students with minoritised ethnic identities. Methods: A mixed methods study combining (1) a survey to establish the number and …

Expression Of Customer (Dis)Satisfaction In Online Restaurant Reviews: The Relationship Between Adversative Connective Constructions And Star Ratings, Matthew J. Baker, Brett James Hashimoto

Faculty Publications

Online restaurant reviews contain expressions of customer expectations in prose as well as in star ratings that indicate overall customer satisfaction. In prose, one way customers communicate that expectations are or are not met is through a grammatical construction called adversative connectives (ACs) (i.e., constituents such as but, although, however, and even though). In the present study, we examine the relationship between star ratings and customers’ use of ACs by employing a combination of content analysis, mixed-effects models, and thematic analysis in a corpus of nearly 35,000 online reviews for restaurants located in the United States. The results reveal an …

Immediate Repeated Reading Has Positive Effects On Reading Rate For English Language Learners: An Eye-Tracking Study, Jennifer Hemmert Hansen, Grant Eckstein, Troy L. Cox, Steven G. Luke, Krista Rich

Faculty Publications

Fluent and skillful reading in English requires efficient and automatic letter and word recognition. Dysfluent reading can affect motivation for reading in English language learners, thereby limiting access to a wealth of language input from written texts. Extensive research of repeated reading in first language (L1) settings has been shown to increase reading rate, while comparatively little research has been done on repeated reading in second language (L2) settings. The objective of this eye-tracking study was to accurately document early and late reading processes in an immediate repeated reading exercise to observe how repeated reading affects reading rate in adult …

Putting Students In Their Place. The Role Of Placement Testing In Language Programs, Troy L. Cox, Matthew P. Wilcox

Faculty Publications

A perennial issue that nearly all language programs face with the arrival of new students is: where is the best place for each student to begin their course of study within our curricular structure given their current language abilities? When students have no previous language learning experience, the decision seems easy: place them in the beginning- level class. But when students have prior experience, deciding where they belong becomes more complicated given the wide range in the quality and quantity of previous exposure and the level of ability attained. Programmatic exigencies and resources may constrain student placement even further.

In …

National Association Teachers Of Family And Consumer Sciences Records - Accession 666, Family And Consumer Sciences, National Association Teachers Of

Manuscript Collection

The National Association Teachers of Family and Consumer Sciences records contain handbooks for the organization, the organization’s newsletter, as well as the national convention the organization held. The National Association Teachers of Family and Consumer Sciences (NATFACS) is a nonprofit organization and is an affiliate of the Family and Consumer Sciences Division of the American Vocational Association. “NATFACS serves as a vital link between the state family and consumer sciences associations and the national level. NATFACS purpose is: To provide an organization for group expression and group action dealing with problems of national importance to family and consumer sciences; To …

Greenville Women's History Week Records - Accession 592, Women's History Week, Greenville

Manuscript Collection

The Greenville Women’s History Week Records consist of correspondence, advertisements, program evaluations, introductions, magazine articles, newspaper clippings, minutes, agenda, pamphlets, notes, addresses, photographs, proclamations, radio spots, receipts, resume, and exhibits. The Women’s History Week was created to honor the roles women have played in the history of the United States and this collection documents the organization of the women’s history week celebration in Greenville, SC from 1982-1985.

Scottish Merchant Magazine Collection - Accession 566, Scottish Clans

Manuscript Collection

The Scottish Merchant Magazine Collection consists of copies of The Scottish Merchant newspaper, which changed names to The Scottish American in 1986, from 1983-1990. Also included are copies of The Scottish Banner and Unicorn Limited’s order forms, six pages of abstracts on book collection, and a letter from W.A. Forsyth to W.R. McLeod with an excerpt of “The Forsyth Time,” 1236-1970.

National Association Of Retired Federal Employees (Narfe) Chapter Of Rock Hill, South Carolina Records - Accession 762, Retired Federal Employees, National Association Of - Rock Hill Chapter

Manuscript Collection

The Collection consists of the administrative records and memoranda produced by and related to the National Association of Retired Federal Employees (NARFE) Chapter of Rock Hill, South Carolina Records.

Southern Business Administration Association Records - Accession 683, Southern Business Administration Association

Manuscript Collection

The Southern Business Admission Association Records consists of bylaws and constitution, financial records, membership records, correspondence, minutes, papers relating to meetings, and history relating to the Southern Business Administration Association from 1964 through 1985. At the time, the Southern Business Administration Association consisted of 220 schools in 17 Southern states. The Southern Business Administration Association was founded in 1964 with the objective of promoting and improving collegiate education for business. Former Winthrop professor and Dean of the Business Department, Dr. Jerry H. Padgett was president of the organization during the 1977-1978 fiscal year and was treasurer during most of the …