Digital Commons Network^™

Few-Shot Learning For Ner Using Maml, Nourchene Bargaoui

Theses and Dissertations

This thesis investigates the application of Few-Shot Learning (FSL) using Model-Agnostic Meta-Learning (MAML) to enhance Named Entity Recognition (NER) within the domain of Natural Language Processing (NLP), specifically focusing on chemical datasets. The primary challenge addressed is the impracticality of relying on extensive annotated datasets, especially in specialized fields like chemistry. The research primarily explores the concept of Few-Shot Learning, aiming to train models on minimal data while maintaining performance across diverse tasks. It delves into the N-way K-shot methodology, where "N" represents the number of classes and "K" signifies the number of examples per class. This approach is further …

Online Racism And Mental Health Symptomatology Among Black Adolescents: A Longitudinal Examination, Stephen M. Gibson

Theses and Dissertations

Online racism (i.e., racism perpetrated and embedded within media and platforms on the Internet) is increasingly becoming a public health concern. Recent empirical evidence demonstrates that over a three year period, Black adolescents reported experiencing at least one online racial discriminatory incident, including exposure to racist images or videos within digital spaces (Tynes et al., 2020). One way in which Black adolescents are exposed to online racism is through the consumption of digital news media on the coverage of racially traumatic events (e.g., murders of Black men and women by police officers, racial hate crimes committed against Black people) and …

Determining The Viability Of A Novel Osl Film Dosimeter For In Vivo Dosimetry, Nicholas D. Wilson

Theses and Dissertations

Purpose:

In this work we test the Optically Stimulated Luminescent (OSL) film dosimeter’s different characteristics such as Monitor Unit (MU) linearity, dose rate dependence, and determined its viability for In Vivo Dosimetry (IVD).

Methods:

A prototype BaFBr OSL film was cut into 6 even pieces and the pieces were irradiated on a Trilogy 21EX Varian linac and tested for different characteristics. The standard setup was 6 MV photon beam, with gantry and collimator at 0,10 cm depth and 1.5 cm back scatter. The reader warmup time and fading were calculated, and a standard time was determined and used for the …

Exploring The Relationship Of Intact Limb Knee Joint Loading With Step Lengths And Step Length Symmetry In Individuals With Lower Limb Amputation, Edward D. Syrett

Theses and Dissertations

Individuals with unilateral lower limb amputation (LLA) frequently experience intact limb knee pain, dysfunction, and osteoarthritis. These problems can worsen pre-existing reductions in mobility and quality of life that this population regularly experiences. It is widely accepted that knee joint loading is implicated in the development of knee joint issues, and intact limb knee joint load alterations are thought to be widespread in individuals with LLA. Prior work suggests that gait deviations frequently present in this population may be a contributory cause of these altered forces. These deviations can take many forms, but individuals with LLA commonly demonstrate alterations in …

Fitbit Engagement In An Health Physical Activity Intervention For Young Adult Cancer Survivors: A Secondary Analysis Of The Impact Randomized Controlled Trial, Jessica Gomez Smith

Theses and Dissertations

Wearable devices allow for objective remote and real-time data collection and have been increasingly popular among the general public and in mHealth activity (PA) interventions. Despite this, our knowledge of feasibility and efficacy for using wearable devices to increase PA among a particularly vulnerable population—young adult cancer survivors age 18-39 (YACS)—is limited. Engaging in physical activity while undergoing cancer treatment contributes to reduced risk for recurrence and secondary cancers, and can also help to manage treatment side effects. However, there are a multitude of barriers to PA engagement among cancer survivors, with YACS in particular demonstrating low rates of PA. …

Spatial Transcriptomics Unravels Palmitoylation And Zonation- Dependent Gene Regulation Of Aeg-1 In Mouse Liver, Alissa Saverino

Theses and Dissertations

Obesity-induced metabolic dysfunction-associated steatohepatitis (MASH) leads to hepatocellular carcinoma (HCC). Astrocyte-elevated gene-1/Metadherin (AEG-1/MTDH) plays a key role in promoting MASH and HCC. AEG-1 is palmitoylated at residue cysteine 75 (Cys75) and a knock-in mouse representing mutated Cys75 to serine (AEG-1-C75S) showed activation of MASH- and HCC-promoting gene signature when compared to wild-type littermates (AEG-1-WT). The liver consists of 3 zones, periportal, midlobular, and pericentral, and zone-specific dysregulated gene expression impairs metabolic homeostasis in the liver, contributing to MASH and HCC. Here, to elucidate how palmitoylation influences AEG-1-mediated gene regulation in regards to hepatic zonation, we performed spatial transcriptomics (ST) in …

Development Of A Validity Scale For The Icd-11 Personality Disorder Measure (Psi-11), Rae Lutz

Theses and Dissertations

Invalid responding is a significant issue in the utilization of self-report information. Invalid responding can be assessed by stand-alone validity measures or embedded validity scales. The International Classification of Diseases (ICD) is one of two major diagnostic systems which provide guidance on diagnosing personality disorder, with the most recent version (ICD-11) providing a fully dimensional model for personality disorders. No existing measures aimed at assessing dimensional personality pathology have addressed the combination of PD severity and trait qualifiers that were based upon ICD-11 guidelines. To address this gap, Clark et al. (2021) developed the ICD-11 Personality Disorder Measure (PSI-11). However, …

Community Informant And Mental Health Provider Perspectives On Access To Mental Healthcare For Lgbtqia+ Communities In Virginia, Chariz Seijo

Theses and Dissertations

The existing literature on mental health disparities for lesbian, gay, bisexual, transgender, queer, intersex, and asexual (LGBTQIA+) populations suggests members of LGBTQIA+ populations are at greater risk of mental health disorders than cisgender and heterosexual individuals. The COVID-19 pandemic has also exacerbated mental health disparities for many, including LGBTQIA+ populations. Combined with mental health provider shortages and anti- LGBTQIA+ bills across the country, inequities in mental healthcare are a significant concern. This qualitative study was designed to gather unique perspectives of key community informants and mental health providers on their experiences with mental healthcare provision to LGBTQIA+ communities in Virginia. …

Expect: A Speculative Documentary Filmed In Vr Utilizing The Role-Playing Method To Explore Disabilities And Ableism In Science Fiction, Leilei Xia

Theses and Dissertations

Expect is a speculative documentary filmed in Virtual Reality (VR) that features Chinese actors with disabilities to explore, challenge and reimagine the conventional ableist Sci-Fi tropes and the transhumanistic tendency to “fix” or eradicate disabilities through technological enhancement. I invited people with disabilities who are interested in Sci-Fi to do a Role-Playing with me in Virtual Reality (VR), in which they imagine themselves to be living in a future civilization, an alien planet, or an alternate universe. The participants came up with their own fictional characters and built their own world views. I interacted with them by asking questions and …

The Collection: A Third-Place Community Library Design, Camille Rovani

Theses and Dissertations

TOPIC

This project explores the significance of “third places”— informal public gathering spaces like cafés, parks, and libraries — and how design strategies in these spaces can help foster community connection and enhance well-being in a modern context.

PERSONAL RELEVANCE

While working a remote job during the pandemic, I experienced an overwhelming disconnect from the people around me. Like many people during that time, I was depressed. I then took an interest in the positive impacts of community connection on our health and well-being. I became fascinated by the concept of “third places,” a term coined by sociologist Ray Oldenburg …

Levofloxacin Incorporated Extracellular Matrix Nanoparticles For Pulmonary Cystic Fibrosis Infections, Raahi Patel

Theses and Dissertations

Cystic fibrosis (CF) is a progressive genetic disorder that affects around 40,000 people in the United States. CF is characterized by a mutation in the CFTR protein that causes dysregulated ion transport across epithelial cells, producing viscous mucus in the lung that increases bacterial invasion, causing persistent infections and subsequent inflammation. Pseudomonas aeruginosa and Staphylococcus aureus are two of the most common infections in CF patients that are resistant to antibiotics. One antibiotic approved to treat these infections is levofloxacin (LVX) that functions to inhibit bacterial replication, but can be further developed into tailorable particles. Nanoparticles are an emerging inhaled …

Considering Systems Of Power And Black And Latine Students’ Belonging In Stem, Korinthia D. Nicolai

Theses and Dissertations

This dissertation focuses on (a) exploring the need for and strategies to facilitate the integration of Critical Race Theory (CRT) and educational psychology and (b) supporting Black and Latine students through examining the impact of systems of power via the integration of belonging and Critical Race Theory. This dissertation follows a three-paper format. In Paper 1, we recognize that psychology researchers can use CRT to explore race and racism. However, psychology scholars may confront growing pains when integrating CRT due to their respective inquiry worldviews–postpositivism and critical–which result in several tensions. These tensions may limit the uptake of CRT in …

Beyond The Veil: Hijabi Superheroes And The Power Of Representation, Moom Thahinah Ms

Theses and Dissertations

As a Hijabi woman, I am often misrepresented by stereotypical narratives in Western media that obscure my individuality and agency. My thesis addresses the misrepresentation of Hijabi women, challenges audience perceptions, and empowers Hijabi women to confront these narratives.

Informed by design and media discourse, I developed a narrative and a Hijabi superhero character appropriating tropes of Western comic books. The resulting research combines two outcomes: a print-based narrative and a transformative garment. Print media is used to address the lack of Hijabi representation in Western comics while showcasing the character’s ability to combat discrimination. Derived from the comic format, …

Inspiring A Ripple: A Case For Evidence-Based, Biophilic Design For Affordable Housing, Chelcey A. Dunham

Theses and Dissertations

ABSTRACT

RELEVANCE

Currently in the US, 4 million families in need of affordable housing are not housed in affordable units and are spending 30-50% of their monthly income toward rent (Aurand, 2023.) Due to this shortage of affordable housing and the trajectory of its growth, advocacy groups and policy makers are making a push to fund more affordable housing projects. What if the designs of these projects were informed in such a way that individual and community mental health and wellness could be addressed in addition to meeting the demand for affordable, safe shelter? In this way, the return on …

In Shame I Will Find Paradise, Taehee Whang

Theses and Dissertations

As a Korean American non-binary digital artist and designer, my recent explorations have focused on using voice as a medium to articulate nuanced feelings of displacement and the intricate relationships between language, identity, and expression. This journey expands beyond my personal experiences with gender dysphoria, delving into the lives of non-binary and transgender individuals undergoing gender-affirming voice therapy. Through my thesis research, I have developed interactive multimedia installations inspired by dialogues with individuals such as Umico Niwa, who traveled to Korea for voice feminization surgery, and Jeong Yoon Lee from Hyperlink Press, a four-year participant in Hormone Replacement Therapy (HRT). …

Sense Make Before Book, Bradley Sinanan

Theses and Dissertations

“Sense Make Before Book” is an Indo-Caribbean turn of phrase which refers to common sense being more important than book smarts. My sister sent me a post the other day on Instagram of an Trinidadian woman using this phrase, saying it was one of Indo-Caribbean origin. I was interested and asked my mom about it. My mom says that when she was younger my grandpa said it often around their house in Princes Town, Trinidad and Tobago. This adage feels charged thinking about the history of indenture and its effects on the Indo-Caribbean diaspora.

The written word of archival history …

Investigations Of A Nox2 Activator, P47phox, Px Domain Membrane Anchoring Interactions And Inhibition, Angela Develin

Theses and Dissertations

The regulation of cellular signaling across plasma membranes is a well-organized process through cross-talk of biomolecules such as proteins and membranes. Peripheral membrane proteins (PMPs) are a class of water soluble, membrane associated, proteins that play a critical role in transducing such signals. Due to the dynamic nature of their membrane interactions, relatively smooth surfaces, and general lack of deep ligand binding pockets, PMPs are commonly associated with an approximate 85% of the human proteome that is classified as ‘undruggable’ by current drug discovery methodologies. One such PMP, p47^phox, contains a PX domain which is essential in activation …

Obesity Knowledge And Bmi In Caregiver-Adolescent Dyads: A Descriptive Comparative Pilot Study, John Sykes, John Sykes

Theses and Dissertations

Abstract

Background: The prevalence of obesity and associated health risks and costs continue to increase. The majority of these health and cost ramifications manifest in adulthood, making it imperative to intercept the problem during childhood. Unfortunately, an overwhelming majority of the research surrounding adolescents and obesity to date involves subjects that are already overweight or obese, and the focus of those interventions are on secondary and tertiary prevention. Focusing on primary prevention of childhood obesity could ultimately decrease the incidence, prevalence, and disease-related burden to society. It is posited that the 20% difference in obesity prevalence between adults and children …

Politics Of Being A Lover: In Art, (Space) And Kink, Rabeeha Adnan

Theses and Dissertations

Politics of being a lover: in art, (space) and kink explores my relationship with my practice through observations and stories that draw parallels with romance and kink. Narrated as love affairs turned into complex commitment, it shuffles through logics of structural power, control, and communication in the context of praxis and art institutions.

Drugging The Histone Acetyltransferase Ep300 Modulates Alternative Splicing At Schizophrenia Risk Genes, Shravani Malay

Theses and Dissertations

Purpose. We will evaluate the effects of drugging the epigenetic histone acetyltransferase (HAT) enzyme p300, encoded by the schizophrenia risk gene EP300, on genome-wide gene expression in neural cells. We hypothesize that drugging p300 will affect gene expression and alternative splicing of other schizophrenia risk genes. Our motivation is to identify potential new epigenetic treatment avenues for schizophrenia.

Methods. Prior to my joining the lab, an experiment was conducted using the novel p300 HAT inhibitor, A-485, to modulate genomic regulation in a neural cell line (SH-SY5Y). SH-SY5Y cells were exposed to 10μM of A-485 or vehicle (DMSO) for 24 …

Monte-Carlo Method For Identifying Aberrantly Expressed Genes In Cancer, Matthew M. Beltran

Theses and Dissertations

Gene expression provides insight into the functional variations on the cellular level that shape biological phenomena. Several recent sequencing technologies have produced an abundance of expression profiles spurring entirely new disciplines of biological study. With this myriad of data, the new task is deciding how to assess and extract meaningful insights. Identifying genes with expression changes in disease conditions is often the first step in finding potential biomarkers for diagnosis, and targets for pharmaceutical treatments. Parametric statistical tests at the individual gene level have been the conventional approach for finding differentially expressed genes. These tests exhibit high statistical power but …

Dune Dynamics- A Nature-Based Preschool, Aseel Alhaidari

Theses and Dissertations

Sustainability is a global issue that requires collaborative efforts. Environmental values and attitudes are shaped in adults by early exposure to nature. During the COVID-19 pandemic, remote learning increased the attention to nature-based learning from families and the press (Prochner, 2021).

Although many early childhood education approaches for the age group of 3-5 years recognize the importance of holistic development and focus on tailoring the learning experience to the developmental stage of young children, few emphasize the importance of integrating nature as one of the learning tools. Nature-deficit disorder in children means that children spend less time outdoors and in …

Department Chairs’ Impact On The Diversity, Equity, And Inclusion Of Their Departments, Nicholas R. Garcia Ii

Theses and Dissertations

Department chairs serve not only as the leaders of their departments but also as middle managers in their schools, colleges, and universities. While many department chairs see their role as having little authority, they still play an integral role in day-to-day campus operations (Hunt & Jones, 2015). As leaders of their departments, chairs can directly influence the department’s organizational culture (Schein, 2010), including the culture of diversity and inclusiveness. Departments nationwide are being held responsible for increasing the diversity of the faculty and responding to students' calls for diversity. Departmental organizational culture and the role of the chairperson are essential …

Mathematical Modeling And Analysis Of Inflammation And Tissue Repair: Lung Inflammation And Wound Healing In Corals Under Stress, Quintessa Hay

Theses and Dissertations

A variety of insults, including tissue injury and/or exposure to pathogen, elicit an immune response in many organisms. An improperly regulated immune response can result in deleterious effects to the organism. Here we present models for lung injury in young and old mice and models for wound healing in coral reefs.

It is well known that the immune response becomes less effective in older individuals. This is of particular interest in pulmonary insults such as ventilator induced lung injury (VILI) or lung infection. We extended a mathematical model for the inflammatory response to VILI and used experimental data to select …

Dynamic Mathematical Approaches To Understanding Pain In Sickle Cell Disease, Quindel Jones

Theses and Dissertations

In the last 50 years, pain in Sickle Cell Disease (SCD) has become more widely studied thanks to advancements in technology and awareness. Clinical studies, population surveys, pharmaceutical trials, and computational models have been created and conducted to elucidate the mechanisms, treatments, and prediction of Sickle Cell disease pain episodes. Computational models have become quite useful in unraveling disease pathology with the rise in data collection accessibility and advanced computational power. In particular, dynamic mathematical models have been used to investigate Sickle Cell disease pathology and treatment. In this work we conduct a literature review of mathematical models used in …

Exposing The Camera: The Pedagogical Possibilities Of Critical Camera-Based Arts Curriculum, Oscar Keyes

Theses and Dissertations

Cameras are a ubiquitous part of our everyday lives, especially in schools, found in students’ smartphones and state-of-the-art surveillance systems. This research project emerged from an iterative redesign process of a Photography for Art Education course, structured around the camera’s dual nature as a tool for creative expression and social control. While cameras have long been used to address social issues through documentary techniques; this critical eye can be turned onto the apparatus itself. This study drew heavily upon the historical work of Allan Sekula (1986), who observed how easier access to cameras resulted in both democratization (for the People) …

Measuring The Properties Of Rod-Shaped Bacteria By Single-Entity Electrochemistry, Ashley Tubbs

Theses and Dissertations

Antibiotic-resistant bacteria pose a significant and escalating threat to hospitals around the world, necessitating the development of rapid and sensitive detection methods. Single-entity electrochemistry has emerged as a promising approach for detecting and identifying such bacteria, and monitoring the efficacy of antibiotics in real-time. Herein, we employ the translational diffusion equation for circular cylinders to predict the collision frequency of rod-shaped bacteria, informing our experimental setup. Our work demonstrates that lab-fabricated Pt ultramicroelectrodes can sensitively detect bacteria at femtomolar concentrations under migration-controlled conditions. Further, we present a method implemented in MatLab to automate the analysis of step-like signals observed in …

African American Adolescents' Exposure To Community Firearm Violence And Associated Factors, Colleen S. Walsh

Theses and Dissertations

Firearm violence is a public health crisis in the United States that disproportionately impacts African American adolescents and families living in economically marginalized communities. The current firearm violence exposure literature includes a limited focus on the (a) the identification of risk and promotive factors that influence the likelihood of exposure to community firearm violence, (b) is cross-sectional, (c) focuses on outcomes of firearm violence exposure, and (d) does not examine bi-directional relations to determine if risk and promotive factors are causes and/or consequences of firearm violence exposure. This gap in research is further exacerbated by the limited focus on African …

Stereotypes Of A Black Man Misunderstood: The Experiences And Development Of Black Men With Bipolar Disorder On College Campuses, Gerron Scott

Theses and Dissertations

Black men graduate from universities at a lower rate compared to other groups. Students with disabilities also graduate at a lower rate. When the two groups intersect, the results can be disastrous. Black men with bipolar disorder face a host of problems on college campuses. From a lack of sense of belonging to trouble in class, they struggle to stay afloat in college. The purpose of this study was to document the experiences and development of Black men with bipolar disorder on college campuses. A grounded theory approach was used in this study. Grounded theory was chosen because it leads …

Revealing The Elusive Mechanism Of Action Of The Lipid Chaperone Fatty Acid Binding Protein 4, Abdul J. Castillo Ibanez

Theses and Dissertations

Fatty acid binding proteins (FABPs) are pivotal in orchestrating lipid trafficking within cells. This dissertation aims to reveal the mechanism of action of adipocyte FABP (FABP4) by meticulously detailing steps for producing uniformly isotopically labeled protein, understanding dynamics and structural changes in aqueous conditions, analyzing protein-membrane interaction with membrane mimicking models, and revealing its membrane-bound state through novel NMR structural elucidation. Chapter 1 provides an overview of FABP4's indispensable role in lipid trafficking, emphasizing its significance in maintaining cellular homeostasis and metabolic regulation. Chapter 2 delves into the optimization of FABP4 protein expression and proposes a high yield recovery and …