Digital Commons Network^™

Glucose-Lowering Agents Developed In The Last Two Decades And Their Perioperative Implications, Basavana Goudra, Geno Merli, Michael Green

Department of Anesthesiology Faculty Papers

The last two decades have provided far more options f both patients and their physicians in the treatment of diabetes mellitus. While dipeptidyl peptidase-4 inhibitors (DPP-4is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been approved for nearly two decades, sodium-glucose cotransporter 2 inhibitors (SGLT-2is) are relatively new. Of interest to perioperative physicians, these drugs present specific perioperative concerns, prompting many societies to issue guidelines. Retained gastric contents due to slow gastric emptying is a significant drawback of GLP-1RAs, increasing the risk of aspiration. Recommendations include withholding GLP-1RAs for a predefined period of time, performing gastric ultrasound to evaluate gastric …

Emata: A Toolbox For The Automatic Extraction And Modeling Of Arterial Inputs For Tracer Kinetic Analysis In [18f]Fdg Brain Studies, Mattia De Francisci, Erica Silvestri, Andrea Bettinelli, Tommaso Volpi, Manu S Goyal, Andrei G Vlassenko, Diego Cecchin, Alessandra Bertoldo

2020-Current year OA Pubs

PURPOSE: PET imaging is a pivotal tool for biomarker research aimed at personalized medicine. Leveraging the quantitative nature of PET requires knowledge of plasma radiotracer concentration. Typically, the arterial input function (AIF) is obtained through arterial cannulation, an invasive and technically demanding procedure. A less invasive alternative, especially for [

METHODS: To assess the toolbox generalizability and present example outputs, EMATA was applied to brain [

RESULTS: EMATA consistently performs IDIF extraction across all datasets, despite differences in scanners and acquisition protocols. Remarkably high agreement is observed when comparing Patlak's K

CONCLUSION: EMATA proved adaptability to different datasets characteristics and …

Loss Of Chop Prevents Joint Degeneration And Pain In A Mouse Model Of Pseudoachondroplasia, Jacqueline T Hecht, Alka C Veerisetty, Mohammad G Hossain, Debabrata Patra, Michele Carrer, Frankie Chiu, Dorde Relic, Paymaan Jafar-Nejad, Karen L Posey

2020-Current year OA Pubs

Pseudoachondroplasia (PSACH), a severe dwarfing condition characterized by impaired skeletal growth and early joint degeneration, results from mutations in cartilage oligomeric matrix protein (COMP). These mutations disrupt normal protein folding, leading to the accumulation of misfolded COMP in chondrocytes. The MT-COMP mouse is a murine model of PSACH that expresses D469del human COMP in response to doxycycline and replicates the PSACH chondrocyte and clinical pathology. The basis for the mutant-COMP pathology involves endoplasmic reticulum (ER) stress signaling through the PERK/eIF2α/CHOP pathway. C/EBP homologous protein (CHOP), in conjunction with a TNFα inflammatory process, upregulates mTORC1, hindering autophagy clearance of mutant COMP …

Determination Of The Kinetic Parameters Of Cholesterol Oxidation Using Cholesterol Oxidase From Streptomyces Sp., Meka Saima Perdani, Heri Hermansyah, Muhamad Sahlan, Dwini Normayulisa Putri, Teguh Pambudi, Anggi Khairina Hanum Hasibuan

Makara Journal of Technology

Cholesterol oxidase (CO) was successfully produced from Streptomyces sp. via the submerged fermentation method, and 69 U/mL enzyme activity was obtained. This study aimed to determine cholesterol oxidation kinetics and the production of CO as a catalyst. The enzyme was diluted to 0.15, 0.075, and 0.00375 U/mL for the oxidation reaction. The substrate was also prepared in three concentrations: 3.23, 6.46, and 12.93 mM. The optimization of conditions for enzymatic cholesterol oxidation was investigated through measurement of the effect of initial cholesterol and enzyme concentrations. Cholesterol concentration was rapidly measured via high-performance liquid chromatography (HPLC). The kinetics of CO were …

From The Ocean To Our Kitchen Table: Anthropogenic Particles In The Edible Tissue Of U.S.. West Coast Seafood Species, Summer D. Traylor, Elise F. Granek, Marilyn Duncan, Susanne Brander

Environmental Science and Management Faculty Publications and Presentations

Microplastics (MPs) and other anthropogenic particles (APs) are pervasive environmental contaminants found throughout marine and aquatic environments. We quantified APs in the edible tissue of black rockfish, lingcod, Chinook salmon, Pacific herring, Pacific lamprey, and pink shrimp, comparing AP burdens across trophic levels and between vessel-retrieved and retail-purchased individuals. Edible tissue was digested and analyzed under a microscope, and a subset of suspected APs was identified using spectroscopy (μFTIR). Anthropogenic particles were found in 180 of 182 individuals. Finfish contained 0.02–1.08 AP/g of muscle tissue. In pink shrimp (Pandalus jordani), the average AP/g was 10.68 for vessel-retrieved and …

Perceptions Of Black Women’S Portraits Of Beauty In Essence Magazine, Dr. Rachel Mingo

Walden Dissertations and Doctoral Studies

Historically, beauty standards in the United States were rooted in White ideals, influencing media portrayals of Black women to align with White features like lighter skin and straightened hair. Although recent studies suggest a slow shift toward a more diverse representation of Black beauty, depictions in magazines still predominantly reflect mainstream Western beauty ideals, leading to potential negative impacts on Black women’s self-esteem and body image. The purpose of this generic qualitative study was to explore how young Black women, ages 18–25, perceive portrayals of Black beauty in Essence magazine. Black feminist thought constituted the theoretical basis for this study. …

New Graduate Nurses' Experiences Of Burnout As They Transition To Practice, Stacy Beth Elliott

Walden Dissertations and Doctoral Studies

Transitioning from nursing school to professional practice is a critical and challenging period for newly graduated nurses. Transition to professional nursing practice is particularly stressful in the first 3 years as new graduates adapt to the high acuity of patient care, which can result in burnout. The purpose of this qualitative study, guided by the conservation of resource theory, was to understand how new graduate nurses describe their experiences of burnout as novice nurses transition in the first 3 years of nursing practice. Fourteen nurses were interviewed using a semi-structured interviews, and Saldana’s two-cycle analysis was used for data interpretation, …

Apex Graphs And Cographs, Jagdeep Singh, Vaidy Sivaraman, Thomas Zaslavsky

Theory & Applications of Graphs

A class G of graphs is called hereditary if it is closed under taking induced subgraphs. We denote by G^{apex} the class of graphs G that contain a vertex v such that G − v is in G. Borowiecki, Drgas-Burchardt, and Sidorowicz proved that if a hereditary class G has finitely many forbidden induced subgraphs, then so does G^{apex}. We provide an elementary proof of this result.

The hereditary class of cographs consists of all graphs G that can be generated from K_1 using complementation and disjoint union. A graph is an apex cograph if it contains a …

Digital Twin And Cybersecurity In Additive Manufacturing, Lidong Wang

Journal of Cybersecurity Education, Research and Practice

Additive manufacturing (AM) has been applied to automotive, aerospace, medical sectors, etc., but there are still challenges such as parts’ porosity, cracks, surface roughness, intrinsic anisotropy, and residual stress because of the high level of thermal gradient. It is significant to conduct the modeling and simulation of the AM process and achieve quality products. Digital Twin (DT) can help AM with forecasting defects/errors through simulation and real-time process monitoring. DT is a concept of Industry 4.0, and its digital structure reflects the real-time behaviors of a cyber-physical or physical system. This paper introduces the progress of DT applications in AM, …

Loss Of Chop Prevents Joint Degeneration And Pain In A Mouse Model Of Pseudoachondroplasia, Jacqueline T Hecht, Alka C Veerisetty, Mohammad G Hossain, Debabrata Patra, Michele Carrer, Frankie Chiu, Dorde Relic, Paymaan Jafar-Nejad, Karen L Posey

Faculty, Staff and Student Publications

Pseudoachondroplasia (PSACH), a severe dwarfing condition characterized by impaired skeletal growth and early joint degeneration, results from mutations in cartilage oligomeric matrix protein (COMP). These mutations disrupt normal protein folding, leading to the accumulation of misfolded COMP in chondrocytes. The MT-COMP mouse is a murine model of PSACH that expresses D469del human COMP in response to doxycycline and replicates the PSACH chondrocyte and clinical pathology. The basis for the mutant-COMP pathology involves endoplasmic reticulum (ER) stress signaling through the PERK/eIF2α/CHOP pathway. C/EBP homologous protein (CHOP), in conjunction with a TNFα inflammatory process, upregulates mTORC1, hindering autophagy clearance of mutant COMP …

Epithelial Barrier Hypothesis: A Systematic Review, Krishna Patel, Peter Lio

Student Publications

Background

The epithelial barriers, which include the skin, the gut, and the respiratory lining, play a crucial role in protecting the body from pathogens and environmental threats. Many harmful toxins are increasingly part of modern life. The increase in usage of these damaging agents in conjunction with the increase in allergic inflammatory conditions suggests that the “epithelial barrier hypothesis”—the concept that damage to the epithelia by external agents can result in dysbiosis, inflammation, and allergy—may explain the rise in these conditions seen in the developed world.

Objective

We sought to assess the evidence for the epithelial barrier hypothesis, with particular …

State Of Utah V. Alberto Frank Hernandez : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

An appeal from a judgment of conviction of aggravated assault, a third-degree felony; and obstructing justice, a class A misdemeanor; in the Third Judicial District Court, Salt Lake County, State of Utah, the Honorable Heather Brereton, presiding. Appellant is incarcerated.

CONNER NELSON (18064) Assistant Solicitor General SEAN D. REYES (7969) Utah Attorney General Attorney for Appellee

ERICK GRANGE (18000) Salt Lake Legal Defender Assoc. Attorney for Appellant

Perceptions Of Black Women’S Portraits Of Beauty In Essence Magazine, Dr. Rachel Mingo

Walden Dissertations and Doctoral Studies

Historically, beauty standards in the United States were rooted in White ideals, influencing media portrayals of Black women to align with White features like lighter skin and straightened hair. Although recent studies suggest a slow shift toward a more diverse representation of Black beauty, depictions in magazines still predominantly reflect mainstream Western beauty ideals, leading to potential negative impacts on Black women’s self-esteem and body image. The purpose of this generic qualitative study was to explore how young Black women, ages 18–25, perceive portrayals of Black beauty in Essence magazine. Black feminist thought constituted the theoretical basis for this study. …

New Graduate Nurses' Experiences Of Burnout As They Transition To Practice, Stacy Beth Elliott

Walden Dissertations and Doctoral Studies

Transitioning from nursing school to professional practice is a critical and challenging period for newly graduated nurses. Transition to professional nursing practice is particularly stressful in the first 3 years as new graduates adapt to the high acuity of patient care, which can result in burnout. The purpose of this qualitative study, guided by the conservation of resource theory, was to understand how new graduate nurses describe their experiences of burnout as novice nurses transition in the first 3 years of nursing practice. Fourteen nurses were interviewed using a semi-structured interviews, and Saldana’s two-cycle analysis was used for data interpretation, …

Perceptions Of Early Childhood System Partners On Career Pathways, Melissa Larson Busby

Walden Dissertations and Doctoral Studies

Researchers have found high-quality early childhood teachers are crucial to high-quality programs for young children. Despite this, there is a significant need for more highly qualified teachers in a southwestern state. The purpose of the qualitative study was to explore the perceptions of early childhood education (ECE) systems partners in one southwestern state regarding the current systems, structures, and policies related to career pathways through the high school, community college, and university levels. The conceptual framework for this study was based on von Bertalanffy’s general systems theory and systems thinkers such as Senge, who detail the complex interactions between systems …

Generative Ai In Shariah Advisory In Islamic Finance: An Experimental Study, Muhammad Noman Jokhio, Muhammad Asif Jaffer

Business Review

Islamic banks adhere strictly to Shariah principles in all operations and offerings, creating a demand for experts proficient in Shariah-compliant banking and finance. This study investigates the potential of using generative AI, specifically Large Language Models (LLMs), to provide Shariah advisory in complex Islamic financing scenarios. The research evaluates general purpose public LLMs—such as ChatGPT, Gemini, and Meta AI—on their ability to identify Shariah compliance issues, cite relevant Shariah references, and propose actionable guidance for resolving compliance challenges in complex Islamic financing scenarios. A qualitative approach was used. The experimental study involved creation of complex, realistic financing scenarios requiring Shariah …

Non(Belonging) Of Ethnic Minority Communities In Britain: Researcher Reflections, Suparna Bagchi

School of Law, Humanities and Social Sciences

Introduction. There is limited research concerning the experiences of people belonging to ethnic minority communities in predominantly White places (Cline et al., 2002; Garland & Chakraborti, 2006; Scourfield & Davies, 2005). Predominantly White places are those that are inhabited by people from ethnic minority communities with restricted communication with places of worship, cultural institutions and educational norms of their communities, for which they do not feel included (DfES, 2004). In these places, these people not only reside in an invisible state (Bhopal, 2014), but their voices also stay unheard (Chakraborti & Garland, 2004) in official records (Pac-Soo & Taylor, 2023). …

Perceptions Of Early Childhood System Partners On Career Pathways, Melissa Larson Busby

Walden Dissertations and Doctoral Studies

Researchers have found high-quality early childhood teachers are crucial to high-quality programs for young children. Despite this, there is a significant need for more highly qualified teachers in a southwestern state. The purpose of the qualitative study was to explore the perceptions of early childhood education (ECE) systems partners in one southwestern state regarding the current systems, structures, and policies related to career pathways through the high school, community college, and university levels. The conceptual framework for this study was based on von Bertalanffy’s general systems theory and systems thinkers such as Senge, who detail the complex interactions between systems …

Exploring Anxiety, Uncertainty Perception, Treatment Experiences, And Coping Strategies: An Interpretative Phenomenological Analysis, Aysun Parlar Yazici, Alyson Norman, Alison Bacon

School of Psychology

No abstract provided.

Assessing State Laws And Regulations On Radon In Us Childcare Centers, Benjamin Poku, Sayed Hussaini

Journal of Global Awareness

In the US, radon is the second most significant contributor to lung cancer, following smoking. Despite this, there is a notable absence of state-level measures and guidelines aimed at managing and mitigating the risks associated with exposure to radon gas. The objective of this research was to investigate whether state-level laws regarding radon in childcare centers have a correlation with the proportion of counties in each state that fall under radon zone 1 (with levels exceeding 4 pCi/L). The research method was secondary analysis. Data was gathered from multiple sources, including the EPA radon website, academic journals, official state government …

Takaful Insurance Industries In Supporting Sustainable Socio-Economic Development In Indonesia, Fera Widyanata, Rasyida Pertiwi, Ahmad Syathiri

Journal of Global Awareness

Over the past four years, the demand for Takaful (Islamic insurance) among Indonesians has risen. Health Takaful has emerged as the most popular, followed by educational Takaful. Health and education are parts of the Human Development Index (HDI) and are closely related to building a stronger foundation for Indonesia's economic development. This study aims to enhance the Islamic finance ecosystem's impact on achieving SDGs, focusing on health (SDG 3), education (SDG 4), and economic growth (SDG 8), which are crucial for Indonesia's development. It discovers a causal relationship between the takaful industry and improvements in the health sector and …

A Study Abroad Immersion And Reflection Of American Liberal Arts Students In Cyprus, Mark Reimer, Yiannis Miralis

Journal of Global Awareness

Ensemble tours abroad, with a liberal arts focus, provide a rich, unique, and highly educational opportunity to make music while experiencing the history, people, language, and culture of another country. Pre-tour preparation, however, requires research and a trusted relationship between the director and the host to ensure that the musicians in both countries enjoy the same degree of excitement and desire to learn from one another. The following article is research that was conducted for an American college wind ensemble tour to Cyprus. In addition to reviewing several books and journals, the authors listened to hours of classical, folk, and …

Brexit And The Spillover Phenomenon: Scotland, Northern Ireland, And Gibraltar, Timea Varga

Journal of Global Awareness

In my research, I examined the consequences of Brexit and the spillover phenomenon. Even though the United Kingdom left the European Union on 31 December 2020 with a deal, the resulting challenges are not solved at all in 2024 either – Brexit has brought to the surface such conflicts that London considered dealt with a long time ago. However, questions of autonomy and independence are not so easy to resolve; they have their roots in history, and in this uncertain situation, they came to the fore again.

Northern Ireland, Gibraltar, and Scotland have always meant sources of conflict for the …

The Kids Know What’S Up: Analyzing Student Poetry For Evidence Of Institutionalized Oppression, Sarah Straub

Journal of Multicultural Affairs

This article explores institutionalized oppression faced by students today. It incorporates student-created poetry as evidence of marginalization, sexism, racism, and discrimination based on legal status. The kids know what’s up. They are acutely aware of the effects of these systems on their own lives. It is the responsibility of the educator to acknowledge this truth and act on it.

Increasing Youth Engagement In Community Heritage And Social Justice Through Implementation Of A Youth Participatory Empowerment Model, Jancarlos Wagner-Romero, Mary Gillis, Lindsay Clemens, Amanda J. Dworak Rowland, Curlinda Mitchell-Blacksheep, Melanie Canaday-Talley

Journal of Multicultural Affairs

Youth in traditionally marginalized communities are often the target of policies and practices without the opportunity to provide input. This article highlights effective strategies to empower youth to become active participants in their communities. Using a Youth Participatory Empowerment Model (YPEM), youth participants from six demographically distinct communities engaged in YPEM-supported activities and strategies to identify and address a need within their community. To gain insight into successful strategies, qualitative data from pre and post implementation focus group interviews and observational field notes informed the conclusions. The participant youth represent tribal, undocumented, rural, suburban, and urban youth from underserved populations. …

Estha And Trans Identity In The God Of Small Things, Clara Reid

Critical Humanities

Gender relationships in The God of Small Things by Arundhati Roy change over the course of the book. In many ways, gender and caste are inseparable from one another in how they interact; it is Estha who bridges the gap between both. Whether consciously or subconsciously, he engages in this transgressive behavior in order to become his sister Rahel. This essay positions Estha as a trans woman longing for a becoming, and it is through his successful pursuit of Rahel in both a queer and psychoanalytic sense that he becomes a woman. This pursuit manifests through transgressive behavior, putting him …

Agency And Identity Crisis In Diasporic Experience: A Study Of Dinaw Mengestu’S The Beautiful Things That Heaven Bears, Phatik Prasad Poudyal

Critical Humanities

This paper examines agency and identity crisis in Dinaw Mengestu’s The Beautiful Things that Heaven Bears, focusing on protagonist Sepha Stephanos' diasporic experience as an Ethiopian refugee in the United States. Against the backdrop of trauma and socio-economic vulnerability, Sepha's struggle to navigate a new cultural landscape reveals the complexities of diasporic identity formation. Through a theoretical lens encompassing concepts of agency and identity discourse, the study analyzes Sepha's inability to exert agency in shaping his destiny, as influenced by his diasporic status and past trauma. Drawing on scholars such as William H. Sewel and Stuart Hall, the paper explores …

Masculinity In Nepali Diaspora Stories, Asmita Bista

Critical Humanities

This article analyzes the construction of masculinity in the anthology Paradesahkaa Kathaa (Stories of a Foreign Country). The stories “Amerikan Pasaport” (American Passport), “Pijjaa Delibharee” (Pizza Delivery), “Diportesana” (Deportation), and “Deshabhaktta” (A Patriot) depict the struggles of male characters in the host country, America. The main aspect of their struggle is maintaining the image of a successful man, as they consider failure to be effeminate. As immigrants, they are doubly burdened because these male characters must construct their identity through their actions. On the one hand, they feel pressured to build a personality that aligns with the attributes …

Homelessness And Uncertain Belonging Of The Bhutanese Nepali Diaspora, Ramji Timalsina

Critical Humanities

Bhutanese Nepali Diaspora is a classic example of Nepali transnational community. Started centuries ago, it was massively developed in the 19^th and 20^th centuries before it was dispersed in the 21^st century. Living in Bhutan as an agricultural and free-of-cost-labour community for the Bhutanese regime, they always believed that Nepali culture, language and king were their own. When Bhutan brought the ‘one culture, one nation’ policy in the 1980s, about a hundred thousand Bhutanese Nepalis were expelled and they returned to Nepal with the belief that Nepal as their ancestor’s land would accept them. But, as the …

Damn The Dams: Framing ‘Schizophrenic’ Discourses Of The Hindu Right, Nandita Ghosh

Critical Humanities

This article examines the concept of schizophrenia as a cultural metaphor in order to analyze the Hindu Right’s contradictory language-framing politics within the public domain, particularly in relation to building mega dams on rivers Narmada and Bhagirathi. In so doing, it intends to examine the nature of the public domain itself that enables such framing politics within the context of late 20^th-early-21^st-century global capital. Language battles in the public domain have intensified during this period, especially through various forms of digital media. In India, the various groups that form the Hindu Right have often mixed the …