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2024

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The Physiological And Performance Consequences Of The Australian Special Forces Selection Course, Angela Uphill Jan 2024

The Physiological And Performance Consequences Of The Australian Special Forces Selection Course, Angela Uphill

Theses: Doctorates and Masters

Special Forces (SF) soldiers are the most elite element of military forces, who have undergone rigorous training in order to prepare them for a wide array of specialised missions. In Australia, entry into the SF is determined through the highly competitive SF Selection Course (SF-SC), which is a gruelling program involving extreme physical demands, psychological stress, and restricted access to sleep and nutrition. The stressors involved in arduous military training events such as the SF-SC can result in significant losses of fat mass and lean mass, disruption to hormonal homeostasis, and significant decreases in neuromuscular capacity, which can potentially increase …


The Commonwealth Of Amnesia: A Collection Of Erasure And Cut-Up Poems Exploring The Forgotten Histories Of Croatian And Yugoslav Peoples In Australia And An Exegesis Obliteration Creates More: Examining The Wreck Of History Through Whiteout, Blackout And Cut-Up Erasure Poetry, Natalie Damjanovich-Napoleon Jan 2024

The Commonwealth Of Amnesia: A Collection Of Erasure And Cut-Up Poems Exploring The Forgotten Histories Of Croatian And Yugoslav Peoples In Australia And An Exegesis Obliteration Creates More: Examining The Wreck Of History Through Whiteout, Blackout And Cut-Up Erasure Poetry, Natalie Damjanovich-Napoleon

Theses: Doctorates and Masters

This thesis consists of two parts, a collection of poems, “The Commonwealth of Amnesia”, and an accompanying exegesis. The collection explores the forgotten histories of Croatian and Yugoslav immigrants in Australia from 1901 to 1957 through the medium of erasure and cut-up poetry, re-arranging words found in nonfiction documents to posit that forgetting can be metaphorically and visually represented through erasure while also re-narrativising a text. Erasure poetry takes a textual document and using whiteout or blackout erases portions of a text, transforming that text into a poem; cut-up poetry rearranges the words of a document in a textual version …


Western Australian Mothers' Experiences Of Breastfeeding Support In Hospital After Birth: A Mixed Methods Study, Justine Van Der Watt Jan 2024

Western Australian Mothers' Experiences Of Breastfeeding Support In Hospital After Birth: A Mixed Methods Study, Justine Van Der Watt

Theses: Doctorates and Masters

Background: The benefits of breastfeeding are well established for infants, mothers and the community, with the World Health Organisation recommending that infants be exclusively breastfed up to six months of age with an achievable goal of 70% globally. Yet in Australia only 15-37% may be reaching that goal. There have also been reported benefits and desires for mothers to be supported with their breastfeeding in order to increase and prolong breastfeeding duration and exclusivity, especially early after birth. However, there is limited research or literature exploring what experiences mothers are having with breastfeeding support, especially during their hospital admissions in …


Spatial And Temporal Variation In Population Genetic Diversity In Seagrasses And The Implications For Resilience, Anna Maria Frouws Jan 2024

Spatial And Temporal Variation In Population Genetic Diversity In Seagrasses And The Implications For Resilience, Anna Maria Frouws

Theses: Doctorates and Masters

Seagrass ecosystems are highly productive and fulfil vital roles in the coastal environment as ecosystem engineers and keystone species. Unfortunately, anthropogenic pressures have resulted in a significant loss of seagrass habitat and associated ecosystem services. The complex and unpredictable nature of these pressures, and their increasing extent and intensity globally, makes resilience-based ecosystem management a valuable approach. Resilience-based management requires knowledge on processes enhancing ecosystem resilience and on actions supporting these processes. Genetic diversity, which is the allelic variation among individuals of a population, has been recognised as one of the pillars of resilient ecosystems. Genetic diversity within a population …


Care-Full Climate Justice Organising: Movement-Based Participatory Action Research On Noongar Boodja, Kylie A. Wrigley Jan 2024

Care-Full Climate Justice Organising: Movement-Based Participatory Action Research On Noongar Boodja, Kylie A. Wrigley

Theses: Doctorates and Masters

Aligned with emerging research agendas for critical (intersectional and decolonial) climate justice, this research aims to co-create place-based knowledges and actions about how communities and movements organise for climate justice. Organising for climate justice in Western Australia (WA) is particularly difficult because of the strong influence of the fossil fuel industry and the prevailing racial capitalist, colonial, and patriarchal responses to climate change in policy and mainstream climate movements. These systems of power often reproduce, for example, intersecting gender, race, and class inequalities, which marginalise communities most impacted by climate injustice. Moreover, many climate activists experience climate distress and burnout. …


Shifting Soil Fungal Communities In Response To Fire And Weed Management In Urban Banksia Woodlands, Aaron Justin Brace Jan 2024

Shifting Soil Fungal Communities In Response To Fire And Weed Management In Urban Banksia Woodlands, Aaron Justin Brace

Theses: Doctorates and Masters

This research aims to fill the knowledge gap in soil fungi in the Banksia woodland and emphasizes considering holistic ecosystem dynamics in invasive species management strategies. This is accomplished by surveying soil fungi under different fire regime across the Swan Coastal Plain, and within both in and ex situ herbicide application trials. This is the first such study to investigate the fungal component of the Banksia woodland so thoroughly. Chapter 2 quantified and analysed changes in soil fungal community composition and functional groups over a 50-year fire chronosequence in fire-prone Banksia woodland in southwestern Australia. Effects were variable, but fungal …


Verbal And Nonverbal Communicative Approaches Used By Reading Teachers To Foster Student Reading For Pleasure In Secondary School, Claire Patricia Smith Jan 2024

Verbal And Nonverbal Communicative Approaches Used By Reading Teachers To Foster Student Reading For Pleasure In Secondary School, Claire Patricia Smith

Theses: Doctorates and Masters

The benefits of reading for pleasure are diverse. As evidence supporting the value of reading for pleasure grows, so does its legitimacy as a catalyst for positive personal and cognitive development, and as a stand-alone subject in education. Reading for pleasure pedagogy (RfPP), distinct from reading instruction, is evolving in tandem with these findings. This pedagogy is predicated on the profile of a Reading Teacher (RT) as a reader who enjoys reading and is prepared to share their personal reading lives to teach their students to read for pleasure. However, this profile may be an ideal rather than the norm. …


The Experiences Of Older Immigrants Living With Dementia In Australia: A Multi-Method Secondary Analysis, Pelden Chejor Jan 2024

The Experiences Of Older Immigrants Living With Dementia In Australia: A Multi-Method Secondary Analysis, Pelden Chejor

Theses: Doctorates and Masters

The ageing immigrant population and rising dementia cases underscores the need for culturally appropriate dementia care services. However, accessing dementia care services can be challenging for immigrants due to cultural and linguistical differences including their health beliefs. Understanding the experiences and concerns of older immigrants living with dementia is imperative for the planning and delivery of culturally and linguistically appropriate care. The aim of this thesis was to explore and describe the experiences of older immigrants living with dementia, as well as to describe and compare (against non-immigrants living with dementia) the characteristics (neuropsychiatric symptoms and pain characteristics) of older …


Crop Yield Using Novel Parametric L-System Plant Modelling, Christopher Cameron Napier Jan 2024

Crop Yield Using Novel Parametric L-System Plant Modelling, Christopher Cameron Napier

Theses: Doctorates and Masters

This research considers a system for the recognition of real plant parts through image analysis based upon synthetic plant modelling. It aims to use data pipelines and synthetic datasets to define recognizable features that assist in the efficient analysis of real plants and plant images. This research asks about the efficacy of L-systems in accurately simulating wheat crop characteristics. It specifically focusses on readable, understandable, accurate, and complex L-system algorithms. The research examines wheat crops in terms of phenotypes and examines the accuracy of a dataset in support of real image annotation. The methodology used was experimental in nature and …


Improving Growth Models Of Cultivated Sugar Kelp, Saccharina Latissima, By Accounting For Intraspecific Variation In Thermal Tolerance, Ruby Krasnow, Sara Gonzalez, Scott Lindell Jan 2024

Improving Growth Models Of Cultivated Sugar Kelp, Saccharina Latissima, By Accounting For Intraspecific Variation In Thermal Tolerance, Ruby Krasnow, Sara Gonzalez, Scott Lindell

Student Publications [Scholarly]

Dynamic models of sugar kelp (Saccharina latissima) growth are used to estimate the production potential of seaweed aquaculture in many regions around the world. These models do not currently account for the existence of S. latissima ecotypes that are adapted to regional environmental conditions, particularly temperature. We tested the hypothesis that recalibrating the temperature parameters of a dynamic energy budget model using literature data for S. latissima from regions with a similar climate to the region of interest would result in more accurate predictions than using a general species-wide temperature response curve. Calibrating the model using data from warm regions …


'We' Instead Of 'Me': How Buen Vivir Indigenous Cosmopraxes Allow Us To Conceive Security Differently And Face Insecurities Together, Juliano Cortinhas, Yara Martinelli, Ricardo Barbosa Jan 2024

'We' Instead Of 'Me': How Buen Vivir Indigenous Cosmopraxes Allow Us To Conceive Security Differently And Face Insecurities Together, Juliano Cortinhas, Yara Martinelli, Ricardo Barbosa

Student Publications [Scholarly]

Although Critical Security Studies (CSS) has done much to advance security debates, some shortcomings remain. Its excessive focus on the individual - which we term 'me' - reduces CSS' capacity to propose solutions to current global security problems such as pandemics and climate change. This paper contributes to the emerging scholarship on the potential of relational ontologies in Security Studies by introducing Buen Vivir Indigenous cosmopraxes into the debate. Indigenous cosmopraxes such as Sumak Kawsay, Suma Qamaña, and Teko Kavi, we argue, can inform CSS by providing alternative considerations to the pluriverse of ideas that address security crises. These cosmopraxes, …


The Assessment Of Floating Offshore Wind Turbines In Extreme Conditions, Andre Onife Alwyn White Jan 2024

The Assessment Of Floating Offshore Wind Turbines In Extreme Conditions, Andre Onife Alwyn White

School of Engineering, Computing and Mathematics Theses

The purpose of this research is to assess if a floating offshore wind turbine (FOWT) system that is suitable for the environmental conditions in the Scottish North Sea (SNS) is also suitable for the environmental conditions in the Jamaica Caribbean Sea (JCS). A FOWT within Jamaica is an important structure because it produces renewable energy which helps to reduce the dependence on fossil fuel as the primary source of energy. At the same time, it also contributes to reducing global warming caused by climate change effects. These structures, therefore, must be robust enough to withstand the most extreme environmental conditions …


Social Connections And Social Identity As A Basis For Learning And Support: Experiences Of Medical Students With Minoritised And Non-Minoritised Ethnic Identities, Stephanie Bull, Rohini Terry, Neil Rice, Daniele Carrieri, Mark Tarrant, Gerens Curnow Jan 2024

Social Connections And Social Identity As A Basis For Learning And Support: Experiences Of Medical Students With Minoritised And Non-Minoritised Ethnic Identities, Stephanie Bull, Rohini Terry, Neil Rice, Daniele Carrieri, Mark Tarrant, Gerens Curnow

School of Psychology

Background: Social connections between medical students provide a key basis for learning and support. These connections, and associated social identity, may be patterned by ethnicity, and students often perform similarly academically to those they connect with. The mechanisms that underpin the formation of these connections and the role that they play are not fully understood. This study explored how medical students connect with each other, and the potential impact of this on their academic attainment and well-being, with a focus on students with minoritised ethnic identities. Methods: A mixed methods study combining (1) a survey to establish the number and …


Peer Inclusion And School Equality Norm Associations With Intergroup Contact, And Academic Self-Efficacy Amongst Ethnic Majority And Ethnic Minority Youth, Shelley Mckeown, Gian Antonio Di Bernardo, Jaysan Charlesford, Loris Vezzali, Thia Sagherian-Dickey Jan 2024

Peer Inclusion And School Equality Norm Associations With Intergroup Contact, And Academic Self-Efficacy Amongst Ethnic Majority And Ethnic Minority Youth, Shelley Mckeown, Gian Antonio Di Bernardo, Jaysan Charlesford, Loris Vezzali, Thia Sagherian-Dickey

School of Psychology

Social norms are important predictors of youth attitudes and behaviours. There is substantial evidence that positive and meaningful intergroup contact supported by inclusive norms can have a range of benefits beyond prejudice reduction. The present research explores whether perceived peer inclusion norms and perceived norms of equality in school are associated with better quality and more frequent intergroup contact and in turn, whether these are associated with better academic self-efficacy. To test these assertions, we conducted a cross-sectional survey with ethnic majority and ethnic minority youth aged 11–12 (n = 629, 48% female, 43% minority ethnic) attending one of four …


Open‐Label, Clinical Trial Extension: Two‐Year Safety And Efficacy Results Of Seladelpar In Patients With Primary Biliary Cholangitis, Marlyn J. Mayo, John M. Vierling, Christopher L. Bowlus, Cynthia Levy, Gideon M. Hirschfield, Guy W. Neff, Michael R. Galambos, Stuart C. Gordon, Brian B. Borg, Stephen A. Harrison, Paul J. Thuluvath, Aparna Goel, Mitchell L. Shiffman, Mark G. Swain, David E.J. Jones, Palak Trivedi, Andreas E. Kremer, Richard J. Aspinall, David A. Sheridan, Yvonne Dörffel, Ke Yang, Yun Jung Choi, Charles A. Mcwherter Jan 2024

Open‐Label, Clinical Trial Extension: Two‐Year Safety And Efficacy Results Of Seladelpar In Patients With Primary Biliary Cholangitis, Marlyn J. Mayo, John M. Vierling, Christopher L. Bowlus, Cynthia Levy, Gideon M. Hirschfield, Guy W. Neff, Michael R. Galambos, Stuart C. Gordon, Brian B. Borg, Stephen A. Harrison, Paul J. Thuluvath, Aparna Goel, Mitchell L. Shiffman, Mark G. Swain, David E.J. Jones, Palak Trivedi, Andreas E. Kremer, Richard J. Aspinall, David A. Sheridan, Yvonne Dörffel, Ke Yang, Yun Jung Choi, Charles A. Mcwherter

Peninsula Medical School

Background Seladelpar is a potent and selective peroxisome proliferator-activated receptor-δ agonist that targets multiple cell types involved in primary biliary cholangitis (PBC), leading to anti-cholestatic, anti-inflammatory and anti-pruritic effects. Aims To evaluate the long-term safety and efficacy of seladelpar in patients with PBC. Methods In an open-label, international, long-term extension study, patients with PBC completing seladelpar lead-in studies continued treatment. Seladelpar was taken orally once daily at doses of 5 or 10 mg with dose adjustment permitted for safety or tolerability. The primary analysis was for safety and the secondary efficacy analysis examined biochemical markers of cholestasis and liver injury. …


Enhancing Pitch Stability In Floating Wind Platforms: The Hydrodynamic Effects Of Thin Plates, Ignacio Pregnan Johannesen Jan 2024

Enhancing Pitch Stability In Floating Wind Platforms: The Hydrodynamic Effects Of Thin Plates, Ignacio Pregnan Johannesen

School of Engineering, Computing and Mathematics Theses

The Floating Offshore Wind Turbines (FOWT) technology is still at an early stage looking for ways to make it competitive. In the case of semi-submersible FOWT the large structure has been pointed as an option to tackle the final energy price and therefore, smaller/cheaper platforms are desired. However, this would have implications on the platform hydrodynamic performance. This thesis discusses the use of thin disks as pitch motion suppression surfaces for FOWT platforms, employing three methodologies; potential flow, Computational Fluid Dynamics (CFD) and Experiments. With NEMOH a boundary element method code, the added mass and excitation forces/moments were calculated for …


Data Security And User Authentication In Public Cloud Computing Environments, Nelson Vasconcelos Soares Dos Santos Jan 2024

Data Security And User Authentication In Public Cloud Computing Environments, Nelson Vasconcelos Soares Dos Santos

School of Engineering, Computing and Mathematics Theses

Cloud computing has become a prevalent paradigm for organisations and individuals, offering a range of services and resources that enable the efficient management, processing and storage of large quantities of data. However, despite its numerous advantages, cloud computing also presents significant challenges related to data security and user authentication. The distributed nature of cloud environments, coupled with the relinquishment of control over data to cloud service providers, has raised concerns regarding data vulnerability to various types of attacks, such as data breaches, malware injection, and denial of service. Moreover, traditional password and token-based authentication methods have been shown to be …


Cheating And The Effect Of Promises In Indian And German Children, Patricia Kanngiesser, Jahnavi Sunderarajan, Jan K. Woike Jan 2024

Cheating And The Effect Of Promises In Indian And German Children, Patricia Kanngiesser, Jahnavi Sunderarajan, Jan K. Woike

School of Psychology

Cheating is harmful to others and society at large. Promises have been shown to increase honesty in children, but their effectiveness has not been compared between different cultural contexts. In a study (2019) with 7- to 12-year-olds (N = 406, 48% female, middle-class), voluntary promises reduced cheating in Indian, but not in German children. Children in both contexts cheated, but cheating rates were lower in Germany than in India. In both contexts, cheating decreased with age in the (no-promise) control condition and was unaffected by age in the promise condition. These findings suggest that there may exist a threshold beyond …


The Importance Of Acoustic Output Measurement And Monitoring For The Replicability Of Transcranial Ultrasonic Stimulation Studies, Miriam C. Klein-Flügge, Elsa F. Fouragnan, Eleanor Martin Jan 2024

The Importance Of Acoustic Output Measurement And Monitoring For The Replicability Of Transcranial Ultrasonic Stimulation Studies, Miriam C. Klein-Flügge, Elsa F. Fouragnan, Eleanor Martin

School of Psychology

No abstract provided.


Facial First Impressions Following A Prison Sentence: Negative Shift In Trait Ratings But The Same Underlying Structure, Coral M. Coutts, Chris Longmore, Mila Mileva Jan 2024

Facial First Impressions Following A Prison Sentence: Negative Shift In Trait Ratings But The Same Underlying Structure, Coral M. Coutts, Chris Longmore, Mila Mileva

School of Psychology

The first impressions we form of unfamiliar others can often guide many important decisions such as whether someone is guilty of a crime or the severity of their sentence, even in the presence of more relevant information. While most of the current work in this context has focused on their impact during trial proceedings and sentencing, little is known about the potential impact of first impressions following a guilty sentence and the success of the subsequent reintegration into society. Here, we used a data-driven approach to address this question by first collecting unconstrained spontaneous impressions from two groups of perceivers …


Gendered Violence And Sexualized Representations In Video Games: (Lack Of) Effect On Gender-Related Attitudes, Liam Cross, Linda K. Kaye, Juris Savostijanovs, Neil Mclatchie, Matthew Johnston, Liam Whiteman, Robyn Mooney, Gray Atherton Jan 2024

Gendered Violence And Sexualized Representations In Video Games: (Lack Of) Effect On Gender-Related Attitudes, Liam Cross, Linda K. Kaye, Juris Savostijanovs, Neil Mclatchie, Matthew Johnston, Liam Whiteman, Robyn Mooney, Gray Atherton

School of Psychology

This research explored how gender portrayals in video games affect gender-related attitudes. Two hundred participants from the United Kingdom and Malaysia participated across three experiments, where the appearance and behaviour of video game characters were manipulated with regard to target (enemy) gender (Study 1), sexually explicit attire (Study 2) and level of character agency (Study 3). We found minimal evidence that exposure to gender-stereotyped content resulted in differential gender-related attitudes (implicit associations, hostile and benevolent sexism, or rape myth acceptance). However, Study 1 findings showed that individuals who played a first-person shooter with male enemies showed lower endorsement of some …


Reward Count(S): Negative Recency In Probabilistic Experience-Based Learning, Andy Wills, René Schlegelmilch, Bettina Von Helversen Jan 2024

Reward Count(S): Negative Recency In Probabilistic Experience-Based Learning, Andy Wills, René Schlegelmilch, Bettina Von Helversen

School of Psychology

Learning how to make decisions from experience is often studied using probabilistic outcome prediction or choice tasks, asin conditioning, reward learning, or risky gambles (e.g., response A provides reward in 75% of the cases, response B in25% over repeated trials with feedback). One debated phenomenon in such tasks is that of negative recency, describingthat learners expect the rare event after observing a streak ofcommon events (e.g., Gamblers fallacy). Here, we show thatthis behavior, despite instructing participants to use a visualstimulus, also occurs in probabilistic single-cue conditioningtraining, where participants predicted whether digging at a specific location on a plane (visual cue) …


Association Of Life History Strategy And Mate Retention Behavior In Men And Women, Sepide Pazhouhi, Ray Garza, Farid Pazhoohi Jan 2024

Association Of Life History Strategy And Mate Retention Behavior In Men And Women, Sepide Pazhouhi, Ray Garza, Farid Pazhoohi

School of Psychology

From an evolutionary perspective, both men and women use a variety of guarding tactics to keep their romantic partners in the relationship. For men, these benefits increase paternity certainty, while for women, they guarantee male investment in the woman and her children. The current research aimed to explore the association between life history strategy (LHS) and mate retention behaviors in men and women from Iran and the UK. We hypothesized that individuals with a slower life history strategy will show a positive association with benefit-provisioning mate retention (e.g., gift-giving, affection), and a negative association with cost-inflicting mate retention (e.g., emotional …


Co-Producing Ethics Guidelines Together With People With Learning Disabilities, Mary Bottomley, Jodie Bradley, Lisa Clark, Bryan Collis, Bojana Daw Srdanovic, Victoria Farnsworth, Annie Ferguson, Dan Goodley, Andrew Fox, Nikita K. Hayden, Charlotte Lawthom, Rebecca Lawthom, Claudia Magwood, Robert Mclean, Ian Middleton, Alison Owen, Matty Prothero, Simon Rice, Simon Richards, Katherine Runswick-Cole, Kelly Scargill, Rohit Shankar, Toni Ann Wood Jan 2024

Co-Producing Ethics Guidelines Together With People With Learning Disabilities, Mary Bottomley, Jodie Bradley, Lisa Clark, Bryan Collis, Bojana Daw Srdanovic, Victoria Farnsworth, Annie Ferguson, Dan Goodley, Andrew Fox, Nikita K. Hayden, Charlotte Lawthom, Rebecca Lawthom, Claudia Magwood, Robert Mclean, Ian Middleton, Alison Owen, Matty Prothero, Simon Rice, Simon Richards, Katherine Runswick-Cole, Kelly Scargill, Rohit Shankar, Toni Ann Wood

Peninsula Medical School

Background: We are a research team of clinical, academic and advocacy-based researchers with and without learning disabilities, working on the Humanising Healthcare (for people with learning disabilities) project. The project is dedicated to finding and sharing healthcare practices that enhance the lives of people with learning disabilities. As part of our ethics applications to access National Health Service study sites for fieldwork, we worked together to write guiding principles for co-producing research ethics with researchers with learning disabilities. In this paper, we introduce these Participatory Ethics Good Practice Guidelines and reflect on our collaboration. Methods: We reflect on developing the …


The Cost Of Providing Care By Family And Friends (Informal Care) In The Last Year Of Life: A Population Observational Study, Miriam J. Johnson, David C. Currow, Jade Chynoweth, Helen Weatherly, Gamze Keser, Ann Hutchinson, Annie Jones, Laurie Dunn, Victoria Allgar Jan 2024

The Cost Of Providing Care By Family And Friends (Informal Care) In The Last Year Of Life: A Population Observational Study, Miriam J. Johnson, David C. Currow, Jade Chynoweth, Helen Weatherly, Gamze Keser, Ann Hutchinson, Annie Jones, Laurie Dunn, Victoria Allgar

Peninsula Medical School

Introduction: Little is known about replacement costs of care provided by informal carers during the last year of life for people dying of cancer and non-cancer diseases. Aim: To estimate informal caregiving costs and explore the relationship with carer and decedent characteristics. Design: National observational study of bereaved carers. Questions included informal end-of-life caregiving into the 2017 Health Survey for England including estimated recalled frequency, duration and intensity of care provision. We estimated replacement costs for a decedent’s last year of life valuing time at the price of a substitutable activity. Spearman rank correlations and multivariable linear regression were used …


Transformation Of Autophagic Sqstm1 Droplets To Sqstm1-Dependent P-Bodies, Evelina Valionyte, Elizabeth R. Barrow, Chris R. Baxter, Sharon Herath, Shouqing Luo Jan 2024

Transformation Of Autophagic Sqstm1 Droplets To Sqstm1-Dependent P-Bodies, Evelina Valionyte, Elizabeth R. Barrow, Chris R. Baxter, Sharon Herath, Shouqing Luo

Peninsula Medical School

SQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets entirely colocalize with P-body markers, and these stress-induced SQSTM1 droplets contain mRNAs. We thus determined that under certain stress conditions, autophagic SQSTM1 droplets are converted to a type of enlarged P-bodies, designated SQSTM1/p62-dependent P-bodies (pd-PBs). Stress-enhanced SQSTM1 droplet formation drives the nucleation of pd-PBs through the interaction between SQSTM1 and the RNA-binding protein DDX6. Furthermore, pd-PBs sequester PYCARD, facilitating the assembly of NLRP3 inflammasomes, and in turn induce inflammation-related cytotoxicity. Our study suggests that under stress settings, …


Effect Of Skin Tone On The Accuracy Of The Estimation Of Arterial Oxygen Saturation By Pulse Oximetry: A Systematic Review, Daniel Martin, Chris Johns, Lexy Sorrell, Eugene Healy, Mandeep Phull, Segun Olusanya, Mark Peters, Jeremy Fabes Jan 2024

Effect Of Skin Tone On The Accuracy Of The Estimation Of Arterial Oxygen Saturation By Pulse Oximetry: A Systematic Review, Daniel Martin, Chris Johns, Lexy Sorrell, Eugene Healy, Mandeep Phull, Segun Olusanya, Mark Peters, Jeremy Fabes

Peninsula Medical School

Background: Pulse oximetry-derived oxygen saturation (SpO2) is an estimate of true arterial oxygen saturation (SaO2). The aim of this review was to evaluate available evidence determining the effect of skin tone on the ability of pulse oximeters to accurately estimate SaO2. Methods: Published literature was screened to identify clinical and non-clinical studies enrolling adults and children when SpO2 was compared with a paired co-oximetry SaO2 value. We searched literature databases from their inception to March 20, 2023. Risk of bias (RoB) was assessed using the QUADAS-2 tool. Certainty of assessment was evaluated …


Perioperative Oxygenation—What's The Stress?, Joseph Larvin, Mark Edwards, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey Jan 2024

Perioperative Oxygenation—What's The Stress?, Joseph Larvin, Mark Edwards, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey

Peninsula Medical School

Oxygen is the most used drug in anaesthesia. Despite such widespread use, optimal perioperative oxygen administration remains highly controversial because of concerns about the competing harms of both hyperoxia and hypoxia. Notwithstanding a Cochrane review concluding that routinely administering a fractional inspired oxygen concentration (FiO2) >0.6 intraoperatively might increase postoperative morbidity and mortality, the World Health Organization (WHO) currently recommends all anaesthetised patients receive 0.8 FiO2 during and immediately after surgery to reduce surgical site infections. Results from the largest trial available at the time of these two reviews (suggesting long-term survival may be worse with high …


Training Needs For Staff Providing Remote Services In General Practice: A Mixed-Methods Study, Trisha Greenhalgh, Rebecca Payne, Nina Hemmings, Helen Leach, Isabel Hanson, Anwar Khan, Lisa Miller, Emma Ladds, Aileen Clarke, Sara E. Shaw, Francesca Dakin, Sietse Wieringa, Sarah Rybczynska-Bunt, Stuart D. Faulkner, Richard Byng, Asli Kalin, Lucy Moore, Joseph Wherton, Laiba Husain, Rebecca Rosen Jan 2024

Training Needs For Staff Providing Remote Services In General Practice: A Mixed-Methods Study, Trisha Greenhalgh, Rebecca Payne, Nina Hemmings, Helen Leach, Isabel Hanson, Anwar Khan, Lisa Miller, Emma Ladds, Aileen Clarke, Sara E. Shaw, Francesca Dakin, Sietse Wieringa, Sarah Rybczynska-Bunt, Stuart D. Faulkner, Richard Byng, Asli Kalin, Lucy Moore, Joseph Wherton, Laiba Husain, Rebecca Rosen

Peninsula Medical School

Background Contemporary general practice includes many kinds of remote encounter. The rise in telephone, video and online modalities for triage and clinical care requires clinicians and support staff to be trained, both individually and as teams, but evidence-based competencies have not previously been produced for general practice. Aim To identify training needs, core competencies, and learning methods for staff providing remote encounters. Design and setting Mixed-methods study in UK general practice. Method Data were collated from longitudinal ethnographic case studies of 12 general practices; a multi-stakeholder workshop; interviews with policymakers, training providers, and trainees; published research; and grey literature (such …


The Mini-Cog: A Community Screening Tool For Dementia In Indonesia, Yuda Turana, Nicolas Farina, Imelda Theresia, Tara Puspitarini Sani, Ika Suswanti, Fasihah Irfani Fitri, Emiliano Albanese, Adelina Comas-Herrera, Martin Knapp, Sube Banerjee Jan 2024

The Mini-Cog: A Community Screening Tool For Dementia In Indonesia, Yuda Turana, Nicolas Farina, Imelda Theresia, Tara Puspitarini Sani, Ika Suswanti, Fasihah Irfani Fitri, Emiliano Albanese, Adelina Comas-Herrera, Martin Knapp, Sube Banerjee

Peninsula Medical School

Background: Early detection of dementia enables more effective planning and can enable access to treatment and support. The Mini-Cog is a widely used screening instrument in Indonesia; however, this instrument has never undergone a translation and cultural adaptation process. Currently, there is no data on how accurate the tool is against diagnostic criteria, particularly in low-education. Methods: Embedded within the community-based dementia prevalence study was the Strengthening Responses to Dementia in Developing Countries (STRiDE) project; older adults (aged ≥ 65 years) were randomly recruited from sites in Jakarta and North Sumatra, Indonesia. All participants were asked to complete the Mini-Cog …