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Immune Checkpoint Inhibitor-Associated Cutaneous Adverse Events: Mechanisms Of Occurrence, Abdulaziz M. Eshaq, Thomas W. Flanagan, Abdulqader A. Ba Abbad, Zain Alabden A. Makarem, Mohammed S. Bokir, Ahmed K. Alasheq, Sara A. Al Asheikh, Abdullah M. Almashhor, Faroq Binyamani, Waleed A. Al-Amoudi, Abdulaziz S. Bawzir, Youssef Haikel, Mossad Megahed, Mohamed Hassan

School of Medicine Faculty Publications

Immunotherapy, particularly that based on blocking checkpoint proteins in many tumors, including melanoma, Merkel cell carcinoma, non-small cell lung cancer (NSCLC), triple-negative breast (TNB cancer), renal cancer, and gastrointestinal and endometrial neoplasms, is a therapeutic alternative to chemotherapy. Immune checkpoint inhibitor (ICI)-based therapies have the potential to target different pathways leading to the destruction of cancer cells. Although ICIs are an effective treatment strategy for patients with highly immune-infiltrated cancers, the development of different adverse effects including cutaneous adverse effects during and after the treatment with ICIs is common. ICI-associated cutaneous adverse effects include mostly inflammatory and bullous dermatoses, as …

Derivation And Validation Of The Simplified Bleedingaudit Triage Trauma (Sbatt) Score: A Simplified Trauma Score For Major Trauma Patients Injured In Motor Vehicle Collisions, Tim Nutbeam, Willem Stassen, Emily Foote, Francois-Xavier Ageron

School of Health Professions

Objectives To develop and validate a simplified Bleeding Audit Triage Trauma (sBATT) score for use by lay persons, or in areas and environments where physiological monitoring equipment may be unavailable or inappropriate.Design The sBATT was derived from the original BATT, which included prehospital systolic blood pressure (SBP), heart rate, respiratory rate, Glasgow Coma Scale (GCS), age and trauma mechanism. Variables suitable for lay interpretation without monitoring equipment were included (age, level of consciousness, absence of radial pulse, tachycardia and trapped status). The sBATT was validated using data from the UK Trauma Audit Research Network (TARN) registry.Setting Data sourced from prehospital …

A Mid-20th Century Stratigraphical Anthropocene Is Recognisable In The Birth-Area Of The Industrial Revolution, Hannah Sellers, Neil Roberts

More Faculty of Science and Engineering Research

The formalisation of the Anthropocene as a subdivision of the Geological Time Scale has been under debate. Its stratigraphic boundary has been proposed as a precise Global boundary Stratotype Section and Point (GSSP) in the mid-20th century, but it is part of an episode of human-induced changes to the Earth System that have unfolded over millennia. Here we attempt to identify stratigraphical patterns of the Anthropocene from a previously well studied lake sedimentary archive from the English Midlands, located in one of the most heavily human-modified landscapes in the UK, and the birthplace of the Industrial Revolution. Our analysis is …

How Can Clinical Communication Alleviate The Negative Impacts Of Social Determinants Of Health?: A Secondary Hints 6 Dataset Analysis, Grace Ellen Brannon, Tiffany B Kindratt, Qiwei Luna Wu

SAGE Open Access Agreement Publications-Archive

Structural disparities (eg, food insecurities, housing, and lack of transportation) at different social levels (eg, personal, family, and community) are strong determinants of health, influencing individuals’ and population well-being worldwide. Research is scarce examining how clinical communication can mitigate the negative impact of social disparities obstructing the reception of quality healthcare. In this study, we explore the mediation role of patient-centered communication (PCC) between social determinants of health (SDH) and quality of care. Using a sample of 5437 adult who visited a healthcare provider in the past 12 months from the sixth Health Information National Trends Survey (HINTS 6), our …

Production Of Routine Formulae By Chinese Learners Of Thai: An Interlanguage Pragmatic Study, Radarat Sripunvoraskul, Natthaporn Panpothong

Journal of Letters

Routine formulae are expressions used repeatedly in specific situations. While the use of routine formulae is common knowledge for native speakers, second-language learners often find it challenging. This research aims to examine the production and communication problems associated with routine formulae used by Chinese learners of Thai. The study adopts the perspective of interlanguage pragmatics and employs DCT for data collection. Participants include 33 Chinese learners of Thai, ranging from B2 to C2 proficiency levels, and 30 native speakers of Thai. In-depth interviews were also conducted with 30 native speakers. The results reveal that even though they are intermediate to …

Polyaxial Stress-Dependent Tensorial Permeability Variations Of A Columnar Jointed Rock Mass: Insights From 3d Distinct Element Method, Prasad Pothana, Vamegh Rasouli, Kegang Ling

Petroleum Engineering Student Publications

Stress-induced permeability changes in geological formations have implications for various geo-engineering applications. Fractures are the predominant fluid flow pathways within tight geological formations such as jointed basaltic rock mass. Three-dimensional permeability variations of a columnar jointed rock mass using the three-dimensional block distinct element method are investigated. First, a permeability tensor is constructed by simulating fluid flow through joint sets using cubic law and determining its principal components through eigenvector analysis. Subsequently, numerical simulations are conducted to gain insights into the impact of principal stresses on joint deformation and fluid flow. Joint deformation is controlled by the joint’s mechanical properties, …

Challenges And Opportunities In Implementing And Enforcing India’S Loose Cigarette Sales Ban: A Qualitative Stakeholder Analysis, Mayank Sakhuja, Daniela B. Friedman Ph.D., Mark M. Macauda Phd, Mph, James R. Hebert Scd, Mangesh S. Pednekar, Prakash C. Gupta, James F. Thrasher Ph.D., Ma, Ms

Faculty Publications

Introduction Several Indian states have banned the sale of loose cigarettes, and India is considering a national ban. This study examines the perceptions of policymakers, implementers, and law enforcement officials regarding the implementation and enforcement of this ban. Methods Between May–October 2022, we conducted in-depth interviews with 26 key stakeholders involved in tobacco control in two Indian cities, Delhi (where the ban was not implemented) and Mumbai (where the ban was in effect). Participants included representatives from various government departments such as police, municipal corporations, FDA, health, and civil society organizations / NGOs such as Vital Strategies, World Health Organization, …

Evolving Philanthropy Among The Chinese In The Philippines: Then And Now, Jane T. Yugioksing

Chinese Studies Department Faculty Publications

A long history of charitable acts among overseas Chinese especially in the Southeast Asian region, labeled as “diasporic philanthropy,”1 gathered more scholarly attention in recent years. In the Philippines, the complex Chinese diaspora communities layered from first to fifth-generation overseas Chinese to the new Chinese immigrants (NCI) present themselves with multifaceted means of giving back either to their home country or host country. Bearing a sojourner’s mentality, the first generation of Chinese instituted most of their philanthropic action alongside the interest of the motherland, while the succeeding generations navigate their cultural identity and find themselves in the intersection of giving …

Weed Incursion Of Irrigated Forage–Forb Mixtures Under Mob Grazing Or Mowing In The Mountain West Usa, Jennifer Macadam, Jared Gibbons, Xin Dai

Plants, Soils, and Climate Faculty Publications

Improving the quality of irrigated pastures can increase the profitability of ruminant production systems. Increasing pasture plant biodiversity is beneficial for ruminants, pollinators, and soil health, but it is challenging to manage weed incursion in seeded mixed-species pastures. This study assessed the weed incursion that resulted when forage legumes or grasses were seeded as binary mixtures with one of four non-legume forbs. Defoliation occurred at 6-week intervals as either mowing or mob grazing. Forbs were chicory, plantain, Lewis flax, or small burnet and forages were alfalfa, birdsfoot trefoil, creeping foxtail, intermediate wheatgrass, kura clover, meadow bromegrass, orchardgrass, perennial ryegrass, reed …

Stem Cell Activity-Coupled Suppression Of Endogenous Retrovirus Governs Adult Tissue Regeneration, Ying Lyu, Soo Jin Kim, Ericka S Humphrey, Richa Nayak, Yinglu Guan, Qingnan Liang, Kun Hee Kim, Yukun Tan, Jinzhuang Dou, Huandong Sun, Xingzhi Song, Priyadharsini Nagarajan, Kamryn N Gerner-Mauro, Kevin Jin, Virginia Liu, Rehman H Hassan, Miranda L Johnson, Lisa P Deliu, Yun You, Anurag Sharma, H Amalia Pasolli, Yue Lu, Jianhua Zhang, Vakul Mohanty, Ken Chen, Youn Joo Yang, Taiping Chen, Yejing Ge

Faculty, Staff and Student Publications

Mammalian retrotransposons constitute 40% of the genome. During tissue regeneration, adult stem cells coordinately repress retrotransposons and activate lineage genes, but how this coordination is controlled is poorly understood. Here, we observed that dynamic expression of histone methyltransferase SETDB1 (a retrotransposon repressor) closely mirrors stem cell activities in murine skin. SETDB1 ablation leads to the reactivation of endogenous retroviruses (ERVs, a type of retrotransposon) and the assembly of viral-like particles, resulting in hair loss and stem cell exhaustion that is reversible by antiviral drugs. Mechanistically, at least two molecularly and spatially distinct pathways are responsible: antiviral defense mediated by hair …

Magnetized Neutral 2sc Color Superconductivity And Possible Origin Of The Inner Magnetic Field Of Magnetars, Shuai Yuan, Efrain J. Ferrer, Alejandro Pinero

Physics & Astronomy Faculty Publications

In this paper, the neutral 2SC phase of color superconductivity is investigated in the presence of a magnetic field and for diquark coupling constants and baryonic densities that are expected to characterize neutron stars. Specifically, the behavior of the charged gluons Meissner masses is investigated in the parameter region of interest, taking into account, in addition, the contribution of a rotated magnetic field. It is found that up to moderately high diquark coupling constants the mentioned Meissner masses become tachyonic independently of the applied magnetic-field amplitude, hence signalizing the chromomagnetic instability of this phase. To remove the instability, the restructuring …

Multisociety Endorsement Of The 2024 European Guideline Recommendations On Coronary Revascularization, Victor Dayan, Joseph F Sabik, Minoru Ono, Marc Ruel, Song Wan, Lars G Svensson, Leonard N Girardi, Y Joseph Woo, Vinay Badhwar, Marc R Moon, Wilson Y Szeto, Vinod H Thourani, Rui M S Almeida, Zhe Zheng, Walter J Gomes, Dawn S Hui, Rosemary F Kelly, Miguel Sousa Uva, Joanna Chikwe, Faisal G Bakaeen

Faculty, Staff and Students Publications

No abstract provided.

A Conceptual Framework To Assess The Health, Socioeconomic And Environmental Burden Of Chronic Kidney Disease, Charlotte Johnston-Webber, Isaac Bencomo-Bermudez, George Wharton, Robin Van Kessel, Salvatore Barone, Francisco Brotons Muntó, Steven Chadban, Juan Jose Garcia Sanchez, Janwillem Kocks, Kyra Obolensky, Petra Sandow, Neil Skolnik, Ming-Hui Zhao, Alexei Volaco, David Wheeler, Alistair Mcguire, Elias Mossialos

Department of Medicine Faculty Papers

Chronic kidney disease (CKD) is a global health challenge that affects patients, caregivers, healthcare systems, the environment and national economies. Despite its far-reaching impact, there is no framework to systematically evaluate national CKD prevention and management programmes or evaluate the societal burden of disease. This paper has two objectives: first, to introduce a comprehensive framework to assess national programmes, which recognises gaps and weaknesses and identifies feasible policy interventions to reduce overall CKD burden; second, to present some key challenges and success stories in delivering CKD services delivered in eight different country settings. A literature review informed an initial version …

Cochlear Mechanics Are Preserved After Inner Ear Delivery Of Gold Nanoparticles, Dorothy W Pan, Jinkyung Kim, Patricia M Quiñones, Anthony J Ricci, Brian E Applegate, John S Oghalai

2020-Current year OA Pubs

Novel therapeutic delivery systems and delivery methods to the inner ear are necessary to treat hearing loss and inner ear disorders. However, numerous barriers exist to therapeutic delivery into the bone-encased and immune-privileged environment of the inner ear and cochlea, which makes treating inner ear disorders challenging. Nanoparticles (NPs) are a type of therapeutic delivery system that can be engineered for multiple purposes, and posterior semicircular canal (PSCC) infusion is a method to directly deposit them into the cochlea. We sought to assess PSCC infusion of gold NPs into the cochlea, including the NPs' distribution and effect on cochlear mechanics. …

Stereotactic Cardiac Radiotherapy For Refractory Ventricular Tachycardia In Structural Heart Disease Patients: A Systematic Review, Amulya Gupta, Zeeshan Sattar, Nourhan Chaaban, Sagar Ranka, Cameron Carlson, Farhad Sami, Clifford G Robinson, Phillip S Cuculich, Seth H Sheldon, Madhu Reddy, David Akhavan, Amit Noheria

2020-Current year OA Pubs

AIMS: Among patients with structural heart disease with ventricular tachycardia (VT) refractory to medical therapy and catheter ablation, cardiac stereotactic body radiotherapy (SBRT) is a paradigm-changing treatment option. This study aims to assess the efficacy of cardiac SBRT in refractory VT by comparing the rates of VT episodes, anti-tachycardia pacing (ATP) therapies, and implantable cardioverter-defibrillator (ICD) shocks post-SBRT with pre-SBRT.

METHODS AND RESULTS: We performed a comprehensive literature search and included all clinical studies reporting outcomes on cardiac SBRT for VT. Treatment efficacy was evaluated as random-effects pooled rate-ratios of VT episodes, ATP therapies and ICD shocks post-SBRT (after 6-week …

Improving Pediatric Magnetic Resonance Imaging Safety By Enhanced Non-Technical Skills And Team Collaboration, Masashi Uramatsu, Hidekuni Takahashi, Paul Barach, Yoshikazu Fujisawa, Megumi Takahashi, Shiro Mishima, Gaku Yamanaka

College of Population Health Faculty Papers

BACKGROUND: Safe pediatric magnetic resonance imaging (MRI) ideally relies on non-sedative techniques, as avoiding risky sedation is inherently safer. However, in practice, sedation often becomes unavoidable, particularly for younger children or those with anxiety, to ensure motion-free, high-quality imaging. This narrative review explores the current practices and proposes strategies to enhance safety in pediatric MRI examinations.

METHODS: We identified and analyzed 247 studies addressing various aspects of pediatric MRI safety, including sedation protocols, patient monitoring, and team-based management approaches.

RESULTS: Safe sedation requires careful drug selection tailored to individual needs, continuous monitoring, and robust emergency preparedness. While efforts are underway …

Living With Quadriplegia: A Journey Of Personal And Professional Development, James Arkwright

Heroism Science

In this article, I provide an autoethnographic account of the discursive and narrative changes I have experienced and the agency I have found, following an accident thirty-seven years ago that resulted in permanent spinal cord injury. Initially losing my career and identity as a farmer, my hope and survival depended on adopting new frameworks of understanding – both in terms of the physical realities of living with incomplete quadriplegia and in becoming subjectively positioned quite differently than I was as an able-bodied male with farming knowledge and skills. In more recent years, as my spinal health and mobility have deteriorated, …

Beyond Human Perception: The Remarkable Science Of Donald R. Griffin, Gareth Jones

Animal Sentience

Carolyn Ristau shows how Donald Griffin’s revolutionary science sometimes progressed from ridicule, to opposition, to being self-evident. Griffin’s work involved phenomena beyond human perception, making it sometimes difficult for others to fathom. His work on ultrasonic echolocation, navigation and animal cognition has shifted established paradigms. His ‘zoomorphic’ approach provides a realistic framework for understanding how other animals perceive the world.

Thoughts On Servant-Leadership In The Modern Era, Larry C. Spears

International Journal of Servant-Leadership

Compiled by Larry Spears

The Nature Of Grace: An Introduction, Shann Ray Ferch, Jiying Song

International Journal of Servant-Leadership

The International Journal of Servant-Leadership, a humble refraction of the nations of the world, is a staging ground for the most ultimate notions of human love and loss. That a scholarly journal, touched by art, is a proving ground for the question of love in the context of the human and the divine is still a surprising and serendipitous gift to us personally. The binary between art and science has been brought to greater oneness and now social scientists and artists can ask together: Why does love exist? What is the nature of such love, and how might it help …

Stars Maker, Ashley Davis

International Journal of Servant-Leadership

Poem by Ashley Davis

On Servant-Leadership And Quaker Influences, Paul W. Davis, Larry C. Spears

International Journal of Servant-Leadership

One important aspect of the Religious Society of Friends has to do with the nurturance of seekers. The very origins of the Religious Society of Friends had much to do with the fact that 17th-century English seekers were already present and listening when the prophetic visionary leadership of George Fox spoke to their hearts. Out of that union of seekers and prophet grew a powerful spiritual tradition that continues today

A Journey In Servant-Leadership, Larry C. Spears

International Journal of Servant-Leadership

Welcome to our 2024 edition of The International Journal of Servant-Leadership. I would like to offer my special thanks to all of our contributing authors and readers of this journal. Each edition of IJSL contains a wonderful array of articles and papers, poetry and research, film reviews and reflections from around the world that demonstrate many remarkable journeys in servant-leadership

Preface To Song’S “Persuasion Vs. Coercion Or Persuasion And Coercion”, Shann Ray Ferch

International Journal of Servant-Leadership

Song has taken the original work of Greenleaf, specifically his work on seeking to understand the sacred scripture ‘Overcome evil with good,’ and rendered a stunning analysis of great force and vital interrogative essence. Worldwide, fascism is on the rise. Her article does much to ground the human community in the difference between persuasion and coercion, and helps lead us through her own voice that weaves a very fine tapestry with the voices of Greenleaf, Ghandi, Woolman, and Whittier, among others.

Interview With Executive President Fr. Peter Balleis, Sj, Shann Ray Ferch

International Journal of Servant-Leadership

Fr. Peter Balleis, SJ, a leading advocate of refugee and forcibly displaced persons’ rights, has been fighting for human rights and social justice for more than 20 years. As executive president of Jesuit Worldwide Learning (JWL), Fr. Peter works toward a more peaceful world using the power of education.

Interview With Co-Founder Mary Mcfarland, Shann Ray Ferch

International Journal of Servant-Leadership

Dr. McFarland is co-founder of McFarland Consulting where she is engaged in a number of projects serving higher education at the margins, and teaching graduate courses for Georgetown University. She served as the first International Director (President) for Jesuit Worldwide Learning (JWL) Higher Education at the Margins from 2010 to 2016. Prior to that she was Dean of the School of Professional Studies at Gonzaga University in Spokane, WA, and she has held a number of leadership positions in higher education including department chair, chair of faculty senate, and full professor.

Devoted To Healing The Heart Of The World, Shann Ray Ferch

International Journal of Servant-Leadership

In receiving the following narratives of the work of Jesuit Worldwide Learning (JWL) from around the globe, I noticed a deep sense of hunger for the health and well-being of all humanity. This hunger, a seeking and restorative sense of hope and gladness at the heart of people, was pervasive, elegant, incisive, and beautiful in each interview. By setting out to listen to the lives of those working on the front lines of refugee, poverty-ridden, and displaced populations globally, the gift they gave to me personally, to the world of ideas, and the more important world of action is both …

Serendipity In Non-Profit Founding And The Healing Response Of Two Servant-Leaders To Crises Of Migration, Michael T. Von Behren

International Journal of Servant-Leadership

This article explores the intersection of non-profit founding with elements of servant-leadership. Drawing upon current research in social entrepreneurship and non-profit founding, the article reflects on these in light of the stories of two selfless individuals, Varian Fry and Enrique Morones, whose lives of servanthood spawned the founding of two influential organizations: the Emergency Rescue Committee (ERC) and the Border Angels. While sharing the stories of these organizations, and of their founding, this article highlights issues of immigration offering a healing perspective through five themes of servant-leadership articulated by Robert K. Greenleaf revealed in the lives of these non-profit founders. …

Colloquium Servant-Leadership Interviews, Shann Ray Ferch

International Journal of Servant-Leadership

The Jesuit Worldwide Learning (JWL) Colloquium is a group of PhD candidates and others united in providing equitable high quality tertiary learning to people and communities at the margins of societies. These margins, indicated by poverty, location, lack of opportunity, conflict, or forced displacement, define the nature of our shared sense of sisterhood and brotherhood worldwide. The JWL mission and works of mission, enacted daily throughout the world, fulfill Greenleaf’s best test of servant-leadership, bringing greater wisdom, health, autonomy, freedom and service to others, and helps bring about Greenleaf’s notion that the least privileged of society are benefitted and not …