Digital Commons Network^™

Synthesis And Characterisation Of An Acetylcholinesterase Inhibitor, Elijah Rahman-Riding

The Plymouth Student Scientist

Acetylcholinesterase (AChE) inhibitors are currently the only effective treatment for people with Alzheimer’s disease (AD), a fatal neurodegenerative disease that affects 50 million people worldwide at present but is expected to rise dramatically over the next 30 years. The aim of this research was to synthesise an AChE inhibitor derivative of tacrine, 4-chloro-2(((1,2,3,4-tetrahydroacridin-9yl)imino)methyl)phenol (chlorophenol tacrine). This was achieved by first synthesising tacrine, evidencing successful synthesis and assaying purity of the product, then, synthesising a simple derivative, acetyl tacrine, before chlorophenol tacrine. At every stage of the investigation comprehensive structural analysis of each product was obtained using FT-IR, CHN analysis, GC-FID, …

Investigation Of The Use Of Nanotechnology In Food Packaging, Ollie-May Woodland

The Plymouth Student Scientist

This review discusses topics related to the use and development of nanotechnology and nanomaterials in food packaging applications. The accelerated use of these technologies brings about relevant safety, environmental, ethical and legislative/ regulatory concerns and as such the aim of this work is to assess the viability of the use of current commercialised nano-enabled packaging and to evaluate the potential future trends in the progression of these technologies against public opinion and potential risk(s). The data for this report was collected through comprehensive research of nanotechnology and its applications, specifically the packaging industry in the food sector. An online survey …

Influence Of Patch Characteristics On Pollinator Behavior And Seed Production In Centaurea Stoebe, Abigail Hiltke

Theses - ALL

Discontinuous, or patchy, landscapes may affect pollinator foraging behaviors and could potentially lower the fitness of isolated plant communities by limiting and/or altering pollination services. I tested this idea by examining changes in pollinator behavior in patches of spotted knapweed of different size, flower density, and distance from one another. Based on predictions from optimal foraging theory, I identified and measured key pollination promoting behaviors that may change when foragers are exposed to discontinuous landscape. These behaviors were pollinator visitation rates to patches, the number of visits to individual flowers within patches, and the handling time per flower. These factors …

Neuropunk: A Discursive Ethnographic Study Of The Do-It-Yourself Transcranial Direct Current Stimulation Community, Erick Guzman

Electronic Theses and Dissertations

This dissertation seeks to understand the sociocultural contexts surrounding the do-it-yourself (DIY) use of transcranial direct current stimulation (tDCS) devices. TDCS is a non-invasive method of brain stimulation which has a history of use in (1) human brain mapping for basic neuroscience studies, (2) neuropsychological rehabilitation and the treatment of psychological disorders in clinical populations, and (3) cognitive enhancement in healthy people. However, its validity and effectiveness across these uses remain open to debate. Since the early 2010’s, tDCS has attracted a number of lay individuals interested in using it outside of formal scientific and medical contexts. These DIY tDCS …

Understanding Widowhood Cultural Practices, Values, And Beliefs, Of Nigerian American Women: An Ethnonursing Study, Prisca Anuforo

Electronic Theses and Dissertations

Introduction: Many widowhood cultural practices are detrimental to the health and well-being of widows in Nigeria. Little is known about the experiences of widowhood for Nigerian American women, their cultural practices, and how it affects their health.

Purpose: Understand widowhood cultural practices among Nigerian Americans and how these experiences may affect health and wellbeing.

Methods: The qualitative ethnonursing method was used to collect data from 25 Nigerian American widows. Data were analyzed using NVivo qualitative data manager software guided by Leininger’s four phases of qualitative analysis.

Results: Widowhood cultural practices are modified and undertaken to preserve health and honor the …

Ethical Considerations In The Diagnosis And Treatment Of Autism Spectrum Disorder, Ferdinand Okafor

Electronic Theses and Dissertations

This dissertation is an ethical response to the ethical issues in the assessment, diagnosis, and treatment of autism. The problems that underlie the discussion are misconception about autism and Autistics. The misconception about autism and Autistics lead to misinterpretation of the neurological functioning, cognition, and the behaviors of Autistics. Consequently, it influences the approach and model of care in the assessment, diagnosis, and treatment of autism. Currently, the analytic approach and biomedical model of disease are applied in the assessment, diagnosis, and treatment of autism. The motive of the analytic approach and biomedical care is to cure autism. The consequence …

The Ghostly Angel In The Haunted Home: The Haunted House As A Metaphor For A Woman's Body In Crimson Peak, Andrea I. Amado-Fajardo

Theses and Dissertations

Crimson Peak (2015, dir. Guillermo del Toro), often overshadowed by del Toro's more critically acclaimed filmography, deserves to be acknowledged for its central trauma metaphor and its nuanced approach to gender. Far from being merely a horror movie fueled by disturbing sequences such as those found in contemporary supernatural horror films, Crimson Peak slowly unravels how Allerdale Hall parallels the film's female leads as they house and live with ghosts, revenants of a traumatic past. This essay explores the personification of the haunted house as a metaphor for the personified trauma that resides in a woman's body using Crimson Peak …

Journal Staff

Duke Environmental Law & Policy Forum

No abstract provided.

Next Steps In Online Courts: Accelerating Access Tojustice Through Court Technology, J.J. Prescott

Alaska Law Review

For more than a decade, state courts have been expanding access to justice by adopting online dispute resolution (ODR) platforms and other outward-facing communication technologies. At a deep level, these reforms aim at improving society by bolstering the rule of law. At a surface level, these innovations recognize that the justice system works better when courts and law are easier and less costly to understand and use. In important respects, these efforts have been a success. The accessibility of many state courts is considerably more robust today than it was ten years ago, at least for small-stakes cases, like traffic …

Journal Staff

Alaska Law Review

No abstract provided.

When Politics No Longer Stops At The Water’S Edge: Exploring The Effects Of Asymmetric Partisan Polarization On The United States Senate’S Treaty Approval Process, Whitney Baillie-Berring

Dissertations - ALL

The American treaty ratification process is deeply flawed. The Constitutional rules for treaty ratification, specifically that treaties are reviewed by the Senate Foreign Relations Committee prior to voting on the Senate floor and that positive advice and consent requires a 2/3 majority in the Senate, leaves the process rife with opportunities for veto players to prevent treaties from moving through the process. Because treaties are the primary means of codifying international cooperation, the inability to pass treaties has dire consequences for the United States. Recently, the U.S. has increasingly failed to consent to treaty ratification, either through formal rejection or …

The Evolution Of The University Of Al-Anbar Urban Planning Based On The Mental Picture's Diversity And The Contemporary Planning Spaces Filling, Ali Abdulsamea Hameed

Al-Esraa University College Journal for Engineering Sciences

This research concentrated on the role of environmental graphic design (EGD) and the place-making idea in the interior environment of Al-Anbar University. To develop an identity being visual for the University of Al-Anbar internal environment (IE) is this goal of project. The search sought to create and enhance the shape of the internal University of Al-Anbar vacuum by reviving the idea of place building. In order to build and filling the internal emptiness of the campus, the identity being visual must also be strengthened. The descriptive analytical approach was chosen since it was best suited to achieve the goal of …

An Examination Of School Counselor Leadership Practices Related To Burnout, Training Experience, And Caseload, Alan Miller

Dissertations - ALL

School counselors are expected to be leaders in their educational communities. School counselor practices are impacted by a variety of internal and external factors. Leadership practices explored include five dimensions of leadership: Interpersonal Influence, Systemic Collaboration, Resourceful Problem Solving, Professional Efficacy, and Social Justice Advocacy. Burnout experiences explored include five dimensions: Exhaustion, Incompetence, Negative Work Environment, Devaluing Clients, and Deterioration in Personal Life. Leadership training was operationalized as a total number of hours spent in coursework or professional development activities specifically focused on leadership training or practices. Caseload was operationalized as a whole number with a range from 1-1000 students …

Promoting Confidence And Evidence-Based Practices For Attention-Deficit/Hyperactivity Disorder Among Integrated Primary Care Providers: A Qualitive Improvement Education Initiative, Omar Samateh, Margaret Emerson, Kayla Meisinger, Taylor Wilson, Leeza Struwe

Doctor of Nursing Practice Projects: College of Nursing

Introduction: Primary Care Providers (PCPs) are seeing growing number of patients presenting for adult attention-deficit/hyperactivity disorder (ADHD) evaluations as a result of social media influences highlighting ADHD. Yet, PCPs report lacking confidence and education with adult ADHD. The purpose of this quality improvement study was to develop educational materials to promote confidence, competence, and adherence to ADHD evidence-based recommendations among integrated care PCPs. Methods: A literature review and retrospective chart review of 19 patients were used to create 1) Baseline ADHD Provider Education (PE) tool, 2) Standardized ADHD Diagnosis (SAD) referral process, 3) ADHD Assessment, Treatment, and Monitoring …

Minimizing Infant Injury Risk By Utilizing Parental Education In A Primary Care Setting, Courtney Munroe, Erin Kuehl, Rachel Mahlberg

Doctor of Nursing Practice Projects: College of Nursing

Introduction

Accidental injury and death to infants has been correlated to lack of proper education to parents of infants in the primary pediatric care setting. Sudden infant death syndrome (SIDS) and unintentional injuries were the second and third leading causes of post neonatal death during this period of time (Centers for Disease Control and Prevention [CDC], 2016). Studies have found that motor vehicle accidents are a leading cause of child injury and death for infants under 12 months of age. The CDC found that drowning, suffocation, and poisoning were other leading causes that contributed to child injury and death rates …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Organ-On-A-Chip Platforms For Drug Development, Cellular Toxicity Assessment, And Disease Modelling, Muhammad Maaz Khurram, Göktürk Ci̇nel, Özlem Yeşi̇l Çeli̇ktaş, Erdal Bedi̇r

Turkish Journal of Biology

Organ-on-a-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to mimic organ structures onto microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions at a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that recapitulate organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to portray their versatility in investigating drug safety, efficacy, and toxicity. We also reflect upon the potential of OoCs to effectively demonstrate disease models for probable novel therapeutics, …

The Cumulative Effect Of Ellagic Acid And Carnosic Acid Attenuates Oxidative Events During Diabetic Wound Healing: In Different Applications And On Different Days, Eli̇f Naz Gürsoy, Kanuni̇ Barbaros Balabanli, Fatma Nur Tuğcu Demi̇röz, Şule Coşkun Cevher

Turkish Journal of Biology

Background/aim: The hyperglycemic environment in diabetes disrupts normal wound-healing processes, leading to chronic wounds. This study investigated whether the combination of the phenolic compounds Ellagic acid and Carnosic acid shows synergistic effects on diabetic wound healing and oxidative parameters in diabetic rats.Materials and methods: In this study, diabetic rats were divided into control, untreated, Carbopol 974P treated, topical treatment, and oral gavage treatment. Ellagic acid and Carnosic acid combination were applied topically and oral gavage to the full-thickness excisional wounds of all animals except the control group. We investigated oxidative events by malondialdehyde, glutathione, nitric oxide, protein carbonyl, collagen spectrophotometrically, …

Cannabinoid Receptor Ligands Modulate Fibrosis And Inflammation In Idiopathicpulmonary Fibrosis: A Preliminary Study, Sevi̇l Köse, Seli̇n Önen, Merve Gi̇zer, Esi̇n Boduroğlu, Uğur Gönüllü, Petek Korkusuz

Turkish Journal of Biology

Background/aim: There is no specific pharmacological treatment regimen for idiopathic pulmonary fibrosis (IPF). Therefore, new anti-inflammatory therapeutic strategies are needed. Cannabinoids (CBs) that are known for their inflammation-modulating and anti-fibrotic effects may be potential medication candidates for the treatment of IPF. Our aim is to evaluate the inflammation-modulating and anti-fibrotic effects of CB receptor (CBR) agonists and antagonists in lipopolysaccharide (LPS) stimulated human lung healthy fibroblast, epithelial cells, IPF fibroblast cells and monocytes.Materials and methods: We detected CBRs in the human lung healthy (LL24) and IPF fibroblast cells (LL29), epithelial cells (A549) and monocytes (THP-1) by flow cytometry (FC). We …

Development Of An Immunodiagnostic Assay For The Detection Of Sugarcane Mosaic Virus, Hafiz Muhammad Khalid, Najam Us Sahar Sadaf Zaidi, Naeem Rashid, Muhammad Tahir

Turkish Journal of Biology

Background/Aim: Sugarcane mosaic virus (SCMV; genus Potyvirus and family Potyviridae), poses a significant threat to global sugarcane cultivars, including those in Pakistan. The aim of this study was to develop a rapid and effective diagnostic tool for detection of SCMV, enabling timely implementation of control measures to mitigate potential yield losses.Materials and Methods: The study focused on the in silico analysis; physicochemical properties, immunogenicity and subcellular localization of the SCMV coat protein (CP). The SCMV coat protein (CP) gene was synthesized, cloned and expressed in Escherichia coli. The recombinant fusion coat protein (rFCP-SCMV) was purified and used to generate polyclonal …

Combinational Therapy Of All-Trans Retinoic Acid (Atra) And Sphingomyelin Induces Apoptosis And Cell Cycle Arrest In B16f10 Melanoma Cancer Cell, Zeynep İşlek Köklü, Eli̇f Li̇dya Şanverdi̇, Başak Karadağ, Mehmet Hi̇kmet Üçişik, Ezgi̇ Taşkan, Fi̇kretti̇n Şahi̇n

Turkish Journal of Biology

Background: Melanoma arises from the uncontrolled multiplication of melanocytes, posing an escalating global health concern. Despite early detection and surgical removal being crucial, metastatic melanoma poses treatment challenges, with limited options like chemotherapy and immunotherapy. All-trans retinoic acid (ATRA), a natural metabolite of vitamin A, has shown promise in melanoma treatment by inducing differentiation, apoptosis, growth arrest, and immune modulation. However, ATRA treatment alone can lead to resistance and relapse. Sphingomyelin (SM) also plays a role in inhibiting melanoma progression by apoptotic cell death.Objective: This study investigated combinational anticancer effects of ATRA and SM on in vitro B16F10 melanoma cells.Method: …

Mechanistic Insights Into Cardiac Regeneration And Protection Through Meis Inhibition, Aynura Mammadova, Gali̇p Servet Aslan, Li Mo, Qifang Wu, Sebastian Clauss, Fati̇h Kocabaş

Turkish Journal of Biology

MEIS1, a member of the TALE-type homeobox gene family, has emerged as a pivotal regulator of cardiomyocyte cell cycle arrest and represents a promising therapeutic target. Our study reveals that inhibition of MEIS1 using two novel small molecules, MEISi-1 and MEISi-2, significantly enhances neonatal cardiomyocyte proliferation and cytokinesis. Specifically, MEISi-1 and MEISi-2 increased the proportion of proliferating cardiomyocytes (Ph3+TnnT cells) upto 4.5 fold and the percentage of cytokinetic cardiomyocytes (AuroraB+TnnT cells) by 2 fold, compared to untreated controls. MEIS1 inhibition resulted in a notable downregulation of MEIS1 target genes and cyclin-dependent kinase inhibitors, demonstrating its effect on key regulatory pathways. …

Wood-Plastic Composites Integration For Triboelectric Nanogenerator Electricity Generation, Hanbyeol Park, Razamala Yashna F. Dimaporo, Sophia Maureen A. Emperado, Anton Jefferson L. Pangilinan, Juan Carlo T. Gumangan

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Access to electricity in underdeveloped communities is particularly crucial in improving the living standards of people and alleviating poverty by promoting sustainable development. This study deals with the exploration of incorporating wood-plastic composite (WPC) – specifically wood pulp (W) and high-density polyethylene (H) – into triboelectric nanogenerator (TENG) flooring system to convert mechanical energy to electrical energy, promoting sustainable energy, reducing greenhouse gas emissions, improving the quality of life, and serving as feasible flooring tiles. Two types of TENG tiles were prepared by using different WPC ratios: 30W:70H and 70W:30H. A static bending test was conducted to assess the flexural …

“Others, Please Specify”: The Lived Experiences Of Non-Catholic Senior High School Students Studying In A Catholic School, Awani Obhoo, Jadon Reilly G. Garde, Rishae Aeiouffee B. Alcaraz, Andrea Charlize D. Barte, Teresa M. Camarines

Sinaya: A Philippine Journal for Senior High School Teachers and Students

“Others, please specify” is a common option in demographic questions, like when asking respondents’ religious affiliation, that provides them “a text box to self-identify.” This study focused on the said context as it indicated the minority status of non-Catholic students in a predominantly Catholic school and underscored the distinct lived experiences of these students. The relatively small representation of non-Catholic senior high school students studying in Catholic schools piqued curiosity and prompted the need for a deeper examination of their lived experiences. This study aspired to contribute to the development of religious studies in the Philippines, particularly for non-Catholic students …

Predicting The Organizational Citizenship Behaviors (Ocbs) Of Junior High School Teachers, Alfonso B. Astudillo Iii

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Organizational Citizenship Behavior (OCB) plays a crucial role in enhancing organizational effectiveness. This study examines the predictors of OCB among junior high school teachers in the local educational context. Utilizing a quantitative approach, stepwise multiple regression analysis was conducted to identify situational and dispositional variables that predict OCB. Seventeen predictors, including situational variables (type of school, organizational climate, and organizational justice) and dispositional attributes (sex, job satisfaction, work motivation, and personality traits), were analyzed. The findings reveal that while the initial hypothesis was not fully supported, specific variables significantly predicted OCB. Teacher job satisfaction emerged as a significant predictor of …

A Protection Or A Barrier? A Scoping Review Of Boundaries In Teacher-Student Relationships, Joseph Russell R. Santos

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Teacher-student relationships have differing potentialities in terms of importance and challenges, therefore implying the need for more effective navigation by placing healthy boundaries. However, the impact of this relationship and the boundary itself for both teachers and students need to be recognized to determine how they should be navigated. Doing so can give teachers and students healthier and more meaningful classroom experiences that align with the sustainable development goal of achieving optimal well-being and quality education. To examine the perceived importance and challenges of boundaries in teacher-student relationships, a scoping review was conducted. Eleven (11) out of the 29 studies …

Ilaw Ng Ibang Tahanan: Transnational Mothering Practices Of Overseas Filipina Domestic Workers During The Covid-19 Pandemic, Arvin John C. Ramirez

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Filipino mothers traditionally serve as primary caregivers and, at times, as the main breadwinners for their families. With limited opportunities in the Philippines, many seek employment abroad, leaving their children behind. Data from the Philippine Statistics Authority indicated that female Overseas Filipino Workers (OFWs) often engage in elementary jobs, including domestic work and caregiving. The COVID-19 pandemic added a challenge in fulfilling their maternal needs since health and safety have become everyone’s priority. This study investigates the transnational mothering practices of overseas Filipina domestic workers during the pandemic and how these practices differ from those before the health crisis. Through …

Self-Agency As A Strategy In Emergency Remote Learning Among Filipino Grade 10 Students, John Cris C. Tababa, Paul Andrei C. Apo, Golden Grace R. Gammaru, Audrey S. Manaay, Kathrin Anne N. Nadua, James Fhonzy Angelo S. Fontillo

Sinaya: A Philippine Journal for Senior High School Teachers and Students

The Coronavirus disease 2019 pandemic significantly influences students' educational attainment as they actively find and rationalize knowledge obtained from emergency remote learning. As a response, the agency or the ability to regulate one’s learning provides the students with the ability to believe in themselves. Still, it also necessitates the deliberate consideration to create a plan of action and modify it as required to achieve one's objectives. This study obtained knowledge from emergency remote learning (ERL) experiences of Filipino Grade 10 Students in their Social Studies class. The researchers employed a phenomenological approach to understand the self-agency practices of Grade 10 …

Citation Practices Of Contrasting Cultures In Q1 Journal Articles, April Rose C. Gonzales

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Citation is a distinguishing feature in research writing that every researcher must include to ensure credible ethical research. Citing sources is necessary as it provides credit to the original author, refers to previous findings, sets credibility, and enables sustainability of the topic. However, studies least consider culture as an element that influences citation beliefs and practices. Most literature holds a lack of language proficiency as the culprit for poor citation skills. Drawing from Hofstede's Cultural Dimension theory (2011) and Lewis’ (2006) Cultural Behaviour in Relation to Writing, this study explores the influence of culture on citation practices with the hope …

Exploring Student Engagement In A Blended And Gamified Statistics And Probability: Designed With Learning Styles And Player Types, Reymund R. Gonowon

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Educators are called to contribute towards achieving SDG 4: Quality Education. A major determinant in achieving this goal is providing learners with essential skills such as analyzing and interpreting data, making inferences, and driving evidence-based decisions which are the expected competencies in Statistics and Probability (STATPRO), one of the core subjects of the senior high school curriculum in the Philippines. To progress towards SDG 4, achieving the learning competencies of STATPRO is vital, however engaging students in a blended learning environment may be challenging. This study aims to explore the behavioral engagement of students in a gamified STATPRO class through …