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Full-Text Articles in Entire DC Network
Social Capital And The Martial Law Technocracy: The Making And Unmaking Of A Power Elite, Teresa S. Encarnacion Tadem Phd
Social Capital And The Martial Law Technocracy: The Making And Unmaking Of A Power Elite, Teresa S. Encarnacion Tadem Phd
Kritika Kultura
This paper attempts to show the extent to which a faction of the Philippine technocracy during the martial law years utilized its social capital (used interchangeably with cultural capital) to become a potent economic bloc in society only to see it gradually depleted.Led by then Prime Minister and concurrent Finance Minister Cesar E.A. Virata, this bloc consisted of key senior economic officials who were closely associated with IMF-World Bank policies. Their social capital was founded on their family and educational backgrounds, paving the way for their acquisition of the technical expertise required by the business community and later, by government. …
Technology Development Of High-Resolution Single-Cell Lineage Tracing For Cell Reprogramming Systems, Sadie Vanhorn
Technology Development Of High-Resolution Single-Cell Lineage Tracing For Cell Reprogramming Systems, Sadie Vanhorn
Arts & Sciences Electronic Theses and Dissertations
A critical element of cell identity is the cell that created the observed cell. This parent cell dictates many aspects of its identity, whether measured by function, phenotype, or specific assays. The cell’s lineage impacts the ability of the cell to differentiate into final cell types in development or successfully reprogram in direct cell reprogramming. Here, we evolve molecular barcoding techniques to increase the resolution of lineage recording at single-cell resolution. Using single-cell RNA-sequencing as the readout for this measurement, polyadenylated reporter gene transcripts with engineered 3’ untranslated regions were designed to initially label and then record lineage information. While …
Time Reversal Delivery Of Long Duration Noise To A Targeted Location: Achieving Higher Amplitude While Maintaining A Desired Spectral Shape And Maximizing The Spatial Extent, Rylee Scott Russell
Time Reversal Delivery Of Long Duration Noise To A Targeted Location: Achieving Higher Amplitude While Maintaining A Desired Spectral Shape And Maximizing The Spatial Extent, Rylee Scott Russell
Theses and Dissertations
Time Reversal (TR) is a signal processing technique that can be used to focus acoustic waves to a specific location in space, with most applications aiming to create an impulsive focus. This study instead aims to focus long-duration noise signals using TR. This thesis seeks to generate higher amplitude noise at a desired location over an existing method of broadcasting equalized noise. Additionally, this thesis explores various characteristics associated with focusing long duration noise using TR. The dependence of the focal amplitude on the duration of the focused signal is explored as well as the implications of using multiple sources …
Capacity-Weighted Figures-Of-Merit For Battery Transport Metrics, Cj Sturgill, Christopher Sutton, Julian Schwenzel, Morgan Stefik
Capacity-Weighted Figures-Of-Merit For Battery Transport Metrics, Cj Sturgill, Christopher Sutton, Julian Schwenzel, Morgan Stefik
Faculty Publications
New battery materials with improved transport are needed. Typical measurements yield widely varying voltage-dependent diffusivities and reporting practices are diverse. Some materials (e.g. first-order phase change) have most redox occur at a specific voltage and may be sufficiently represented by singular transport metrics. Many rapid intercalation materials, however, exhibit second-order phase transitions with redox over a broad voltage range. How should such cases be compared? The use of capacity-weighted average values is suggested where voltage-dependent metrics are consolidated into representative descriptors as figures-of-merit. Examples are elaborated where differential capacity (dQ/dV) is used to derive a …
An Assessment Of Macroeconomic Effects Of Financial Liberalization In Tanzania: 1990-2022, Cornel Joseph
An Assessment Of Macroeconomic Effects Of Financial Liberalization In Tanzania: 1990-2022, Cornel Joseph
Journal of Humanities and Social Sciences
This study provides a comprehensive analysis of the effects of financial liberalization on key macroeconomic indicators in Tanzania, specifically focusing on savings, investment, and economic growth. Utilizing extensive annual time series data from 1990 to 2022, the research employs the Autoregressive Distributed Lag (ARDL) method and incorporates bound testing procedures to ensure robust results. The analysis reveals several significant findings: financial liberalization has a positive impact on savings and promotes economic growth in the long-run, demonstrating its role as a catalyst for economic advancement in Tanzania. However, the study also uncovers a concerning trend: while savings and growth benefit from …
Community, State And Professionalism: Negotiating The Experience Of Community Health Workers In The Provision Of Maternal And Child Health Services In Tanzania, Chakupewa Joseph Mpambije
Community, State And Professionalism: Negotiating The Experience Of Community Health Workers In The Provision Of Maternal And Child Health Services In Tanzania, Chakupewa Joseph Mpambije
Journal of Humanities and Social Sciences
Research on community health workers (CHWs) has been on the increase in the past decades in Tanzania, focusing on the provision of maternal and child health (MCH) services. While performing their tasks, CHWs work within three constructs: the community, the state, and their professionalism. However, as CHWs work within these constructs, there exists scanty literature which discourses their experiences within the realm of the community, the state and their professionalism. This review aimed to articulate how these constructs facilitate or inhibit CHWs’ performance in improving MCH services. It employed a scoping review method in which peer-reviewed articles and grey literature …
Does Market Accessibility Improve Household Food Security? Evidence From Small-Holder Maize Producers In Southern Tanzania, Monica Sebastian Kauky
Does Market Accessibility Improve Household Food Security? Evidence From Small-Holder Maize Producers In Southern Tanzania, Monica Sebastian Kauky
Journal of Humanities and Social Sciences
This study investigated the impact of market accessibility on household food security among smallholder maize producers in Southern Tanzania, utilizing data from a sample of 407 households primarily engaged in maize farming. Tobit and probit models assessed the relationship between food security and market access. Contrary to expectations, the findings revealed no significant association between market access and food security. Instead, the results underscored the importance of resource availability, indicating that larger farm sizes and higher household wealth indices significantly reduce the risk of food insecurity. These findings suggest that rather than focusing exclusively on enhancing market access, policymakers should …
Terrestrial Evidence For Volcanogenic Sulfate-Driven Cooling Event ~30 Ka Before The Cretaceous–Paleogene Mass Extinction: Volcanism-Induced Cooling ~30 Ka Pre-K–Pg Boundary, Lauren O'Connor, Rhodri Jerrett, Gregory Price, Tyler Lyson, Sabine Lengger, Francien Peterse, Bart Van Dongen
Terrestrial Evidence For Volcanogenic Sulfate-Driven Cooling Event ~30 Ka Before The Cretaceous–Paleogene Mass Extinction: Volcanism-Induced Cooling ~30 Ka Pre-K–Pg Boundary, Lauren O'Connor, Rhodri Jerrett, Gregory Price, Tyler Lyson, Sabine Lengger, Francien Peterse, Bart Van Dongen
School of Geography, Earth and Environmental Sciences
Alongside the Chicxulub meteorite impact, Deccan volcanism is considered a primary trigger for the Cretaceous–Paleogene (K–Pg) mass extinction. Models suggest that volcanic outgassing of carbon and sulfur—potent environmental stressors—drove global temperature change, but the relative timing, duration, and magnitude of such change remains uncertain. Here, we use the organic paleothermometer MBT′5me and the carbon-isotope composition of two K–Pg-spanning lignites from the western Unites States, to test models of volcanogenic air temperature change in the ~100 kyr before the mass extinction. Our records show long-term warming of ~3°C, probably driven by Deccan CO2 emissions, and reveal a transient (<10 kyr) ~5°C cooling event, coinciding with the peak of the Poladpur “pulse” of Deccan eruption ~30 kyr before the K–Pg boundary. This cooling was likely caused by the aerosolization of volcanogenic sulfur. Temperatures returned to pre-event values before the mass extinction, suggesting that, from the terrestrial perspective, volcanogenic climate change was not the primary cause of K–Pg extinction.
Rental Property Demand And Supply Analysis Using Machine Learning, Ahmed Amiri
Rental Property Demand And Supply Analysis Using Machine Learning, Ahmed Amiri
Theses
The real estate market in Dubai is famous for its activity and stimulating potential due to the geographical position of the emirate, well-developed transport and legal framework. Timely determination and prediction of rental price is crucial for investors, property owners and managers, tenants and authorities in their decision making to maximize returns and ensure market stability. Traditional approaches are insufficient for the analysis of the temporal and spatial relations between property characteristics and market processes, which require the use of sophisticated machine learning algorithms. This paper aims to predict the rental prices of properties in Dubai using machine learning models …
Higher Education Reform In Roman Catholic Ecclesiastical Institutions: Responses From French Institutions To Quality Management Imperatives, Marine Condette
Higher Education Reform In Roman Catholic Ecclesiastical Institutions: Responses From French Institutions To Quality Management Imperatives, Marine Condette
Journal of Comparative & International Higher Education
No abstract provided.
Aspiration Of Left Atrial Masses Using The Large-Bore Manual Aspiration System: The Aspirate La Procedure, Shaurya Srivastava, Hussam Al Hennawi, Ahmad Abulshamat, Appa Bandi, Mohammed Qintar
Aspiration Of Left Atrial Masses Using The Large-Bore Manual Aspiration System: The Aspirate La Procedure, Shaurya Srivastava, Hussam Al Hennawi, Ahmad Abulshamat, Appa Bandi, Mohammed Qintar
Abington Jefferson Health Papers
Transcatheter mass extraction of left-sided cardiac masses has gained popularity in recent years, with scarce data on effectiveness, safety, and types of devices used. Mostly, left-sided aspirations use mechanical and continuous-flow–mediated devices (the AngioVac [AngioDynamics] and Penumbra systems [Penumbra]). To our knowledge, the use of manual aspiration devices has not been reported yet. Here, we report the first case series on the use of the AlphaVac (AngioDynamics) (a large-bore manual aspiration device) system for left-sided intracardiac masses.
Technology Development Of High-Resolution Single-Cell Lineage Tracing For Cell Reprogramming Systems, Sadie Vanhorn
Technology Development Of High-Resolution Single-Cell Lineage Tracing For Cell Reprogramming Systems, Sadie Vanhorn
Arts & Sciences Graduate Student Theses and Dissertations
A critical element of cell identity is the cell that created the observed cell. This parent cell dictates many aspects of its identity, whether measured by function, phenotype, or specific assays. The cell’s lineage impacts the ability of the cell to differentiate into final cell types in development or successfully reprogram in direct cell reprogramming. Here, we evolve molecular barcoding techniques to increase the resolution of lineage recording at single-cell resolution. Using single-cell RNA-sequencing as the readout for this measurement, polyadenylated reporter gene transcripts with engineered 3’ untranslated regions were designed to initially label and then record lineage information. While …
Multi-Omic Analysis Of Phototrophic Extracellular Electron Uptake In Novel Rhodovulum Spp. Isolated From A Marine Estuary, Emily J. Davenport
Multi-Omic Analysis Of Phototrophic Extracellular Electron Uptake In Novel Rhodovulum Spp. Isolated From A Marine Estuary, Emily J. Davenport
Arts & Sciences Graduate Student Theses and Dissertations
Microbial metabolisms are incredibly versatile and dynamic, allowing adaptive strategies for growth in even the most limiting environments. For an ever-increasing number of microbes, this includes utilizing soluble or insoluble inorganic mineral species as electron donors, driving geochemical cycles and microbial metabolisms. This metabolic function of transporting electrons derived from the extracellular environment across cell membranes is called extracellular electron uptake (EEU). Within (photo)autotrophs, (p)EEU also sustains CO2 fixation to cell biomass, implicating a potentially fundamental role of microbial carbon cycling in aquatic and soil ecosystems. A model metabolic scheme of pEEU occurring in natural environments is photoferrotrophy, which pairs …
Synthesis Of Higher-Order Catenanes And Catenane-Based Materials, Gray Harlan
Synthesis Of Higher-Order Catenanes And Catenane-Based Materials, Gray Harlan
Arts & Sciences Graduate Student Theses and Dissertations
Catenanes are a subset of mechanically interlocked molecules (MIMs) and are composed of interlocked rings that can be oriented linearly, radially, or branched. A defining feature of all MIMs is that they are bound through their architectures consisting of mechanical bonds, leading to unique topologies. Catenanes have attracted interest due to their stimuli-responsive behavior and the degrees of freedom afforded by the mechanical bond, a feature which is absent with standard covalent bonds. The stimuli responsiveness of catenanes arises from their templated syntheses, where two or more pre-macrocycles are brought together by a driving force. Various templation strategies rely on …
Evaluations Of Digital Public Health Interventions In The Who Southeast Asia Region: A Systematic Literature Review, Nachiket Gudi, Elstin Anbu Raj, Beate Jahn, Uwe Siebert
Evaluations Of Digital Public Health Interventions In The Who Southeast Asia Region: A Systematic Literature Review, Nachiket Gudi, Elstin Anbu Raj, Beate Jahn, Uwe Siebert
Open Access archive
Introduction Digital health technologies have been enhancing the capacity of healthcare providers and, thereby, the delivery of targeted health services. The Southeast Asia Region (SEAR) has invested in strengthening digital public health. Many digital health interventions have been implemented in public health settings but are rarely assessed using the holistic health technology assessment (HTA) approach. Methods A systematic literature review was performed to provide an overview of evaluations of digital public health interventions in the World Health Organization (WHO) SEAR. Searches were conducted on four electronic databases. Screening title abstracts and full texts was independently conducted by two reviewers, followed …
Strategies Small Business Leaders Use To Retain Employees To Reduce Turnover Costs, Karla Gilchrist-Saunders
Strategies Small Business Leaders Use To Retain Employees To Reduce Turnover Costs, Karla Gilchrist-Saunders
Walden Dissertations and Doctoral Studies
Failure to retain employees negatively affects organizational financial sustainability. Small business leaders become concerned when their organizations fail to retain employees, resulting in increased costs and decreased competitiveness, organizational knowledge, team dynamics, and valuable human resources. Grounded in transformational leadership theory, the purpose of this qualitative pragmatic inquiry study was to identify and explore leadership strategies some small business leaders use to retain employees to reduce turnover costs. The participants were six small business leaders in the Washington, DC, metropolitan area with successful strategies used to retain employees to reduce turnover costs. Data were collected from semistructured interviews and publicly …
Pyrophosphate-Free Glycolysis In Clostridium Thermocellum Increases Both Thermodynamic Driving Force And Ethanol Titers, Bishal Dev Sharma, Shuen Hon, Eashant Thusoo, David M. Stevenson, Daniel Amador-Noguez, Adam M. Guss, Lee R. Lynd, Daniel G. Olson
Pyrophosphate-Free Glycolysis In Clostridium Thermocellum Increases Both Thermodynamic Driving Force And Ethanol Titers, Bishal Dev Sharma, Shuen Hon, Eashant Thusoo, David M. Stevenson, Daniel Amador-Noguez, Adam M. Guss, Lee R. Lynd, Daniel G. Olson
Dartmouth Scholarship
Background
Clostridium thermocellum is a promising candidate for production of cellulosic biofuels, however, its final product titer is too low for commercial application, and this may be due to thermodynamic limitations in glycolysis. Previous studies in this organism have revealed a metabolic bottleneck at the phosphofructokinase (PFK) reaction in glycolysis. In the wild-type organism, this reaction uses pyrophosphate (PPi) as an energy cofactor, which is thermodynamically less favorable compared to reactions that use ATP as a cofactor. Previously we showed that replacing the PPi-linked PFK reaction with an ATP-linked reaction increased the thermodynamic driving force of glycolysis, but only had …
Amorfe: An Ai-Integrated Interactive Brainstorming Interface, Ipshita Pal
Amorfe: An Ai-Integrated Interactive Brainstorming Interface, Ipshita Pal
Theses
Amorfe is an interactive multi-touch digital interface that reimagines brainstorming and collaboration using artificial intelligence (AI). Designed to make ideation more dynamic, the platform allows participants to explore, merge, and refine ideas in real time. AI is a creative catalyst, offering unpredictable outcomes and streamlining the brainstorming process. This makes Amorfe engaging, intuitive, and inclusive, encouraging active participation. The platform’s potential was demonstrated through a hypothetical scenario: “How do we create more green spaces on the RIT campus?” Four participants explored various brainstorming phases through touch interaction, leading to the creation of a prototype simulation video and a promotional video. …
Grain Boundary Solute Segregation Across The 5d Space Of Crystallographic Character, Lydia Harris Serafin
Grain Boundary Solute Segregation Across The 5d Space Of Crystallographic Character, Lydia Harris Serafin
Theses and Dissertations
Solute segregation in materials with grain boundaries (GBs) has emerged as a popular method to thermodynamically stabilize nanocrystalline structures. However, the impact of varied GB crystallographic character on solute segregation has never been thoroughly examined. This work examines Co solute segregation in a dataset of 7272 Al bicrystal GBs that span the 5D space of GB crystallographic character. Considerable attention is paid to verification of the calculations in the diverse and large set of GBs. In addition, the results of this work are favorably validated against similar bicrystal and polycrystal simulations. As with other work, we show that Co atoms …
Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Butte Reduction Works (Brw) Phase Ii Interim Demolition Plan Construction Drawings And Floodplain Encroachment Analysis (Dated November 27, 2024), Emma Rott
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Examining The Internet Hunting Styles Of Violent Sexual Predators Who Rape And Murder Their Victims, Rebecca Meyers
Examining The Internet Hunting Styles Of Violent Sexual Predators Who Rape And Murder Their Victims, Rebecca Meyers
Walden Dissertations and Doctoral Studies
The proposed study sought to explore the impact of the internet on the hunting styles of sexual predators who sexually assault and kill their victims. A sample of 32 cases, divided equally among offenders who used the internet to target adult females and those who did not use the internet, was used for the study. The findings showed that various internet-based platforms were used for targeting, including dating apps such as Grindr, Match.com, Meetme.com, Tinder, Craigslist, Sex chat rooms, Kik Messenger, and BDSM sites. Three themes emerged about the impact of the internet on the hunting styles of sexual predators …
Strategies Small Business Leaders Use To Retain Employees To Reduce Turnover Costs, Karla Gilchrist-Saunders
Strategies Small Business Leaders Use To Retain Employees To Reduce Turnover Costs, Karla Gilchrist-Saunders
Walden Dissertations and Doctoral Studies
Failure to retain employees negatively affects organizational financial sustainability. Small business leaders become concerned when their organizations fail to retain employees, resulting in increased costs and decreased competitiveness, organizational knowledge, team dynamics, and valuable human resources. Grounded in transformational leadership theory, the purpose of this qualitative pragmatic inquiry study was to identify and explore leadership strategies some small business leaders use to retain employees to reduce turnover costs. The participants were six small business leaders in the Washington, DC, metropolitan area with successful strategies used to retain employees to reduce turnover costs. Data were collected from semistructured interviews and publicly …
The Psychological And Physical Impact Of The Opioid Crisis On Families, Adrienne Antoinette Hunter Wells Green
The Psychological And Physical Impact Of The Opioid Crisis On Families, Adrienne Antoinette Hunter Wells Green
Walden Dissertations and Doctoral Studies
Many rural areas in the United States have experienced an opioid crisis. Social support programs could be created to address social support for the families affected by opioid addiction. The purpose of this non-experimental, cross-sectional research study was to examine the possible relationship between (a) prescription or non-prescription addiction; (b) opioid addiction or another addiction; (c) the amount of family social support of a family member who has ongoing interactions with the individual struggling with addiction; and (d) stress of the family member in a rural area. Bowen’s family systems theory provided the theoretical framework for the study. A non-probability …
Multi-Antigen Elephant Endotheliotropic Herpesvirus (Eehv) Mrna Vaccine Induces Humoral And Cell-Mediated Responses In Mice, Jessica R Watts, Jennifer L Spencer Clinton, Jeroen Pollet, Rongsheng Peng, Jie Tan, Paul D Ling
Multi-Antigen Elephant Endotheliotropic Herpesvirus (Eehv) Mrna Vaccine Induces Humoral And Cell-Mediated Responses In Mice, Jessica R Watts, Jennifer L Spencer Clinton, Jeroen Pollet, Rongsheng Peng, Jie Tan, Paul D Ling
Faculty, Staff and Students Publications
Background/Objectives: Elephant endotheliotropic herpesvirus (EEHV) causes lethal hemorrhagic disease (HD) in Asian and African elephants in human care and the wild. It is the leading cause of death for young Asian elephants in North American and European zoos despite sensitive diagnostic tests and improved treatments. Thus, there is a critical need to develop an effective vaccine to prevent severe illness and reduce mortality from EEHV-HD. We generated a multi-antigenic EEHV mRNA vaccine to address this need that encodes the EEHV1A-subtype glycoproteins gB, gH, gL, and gO. These conserved proteins are the entry machinery for several herpesviruses in the betaherpesvirus subfamily …
Targeting Corticotropin-Releasing Hormone Receptor Type 1 (Crhr1) Neurons: Validating The Specificity Of A Novel Transgenic Crhr1-Flpo Mouse, Mason Hardy, Yuncai Chen, Tallie Z Baram, Nicholas J Justice
Targeting Corticotropin-Releasing Hormone Receptor Type 1 (Crhr1) Neurons: Validating The Specificity Of A Novel Transgenic Crhr1-Flpo Mouse, Mason Hardy, Yuncai Chen, Tallie Z Baram, Nicholas J Justice
Faculty, Staff and Student Publications
Corticotropin-releasing hormone (CRH) signaling through its cognate receptors, CRHR1 and CRHR2, contributes to diverse stress-related functions in the mammalian brain. Whereas CRHR2 is predominantly expressed in choroid plexus and blood vessels, CRHR1 is abundantly expressed in neurons in discrete brain regions, including the neocortex, hippocampus and nucleus accumbens. Activation of CRHR1 influences motivated behaviors, emotional states, and learning and memory. However, it is unknown whether alterations in CRHR1 signaling contribute to aberrant motivated behaviors observed, for example, in stressful contexts. These questions require tools to manipulate CRHR1 selectively. Here we describe and validate a novel Crhr1-FlpO mouse. Using bacterial artificial …
A Topological Route To Engineering Robust And Bright Supersymmetric Laser Arrays, Soujanya Datta, Mohammad Alizadeh Fard, Ramy El-Ganainy, Krishanu Roychowdhury
A Topological Route To Engineering Robust And Bright Supersymmetric Laser Arrays, Soujanya Datta, Mohammad Alizadeh Fard, Ramy El-Ganainy, Krishanu Roychowdhury
Michigan Tech Publications
In recent years, several proposals that leverage principles from condensed matter and high-energy physics for engineering laser arrays have been put forward. The most important among these concepts are topology, which enables the construction of robust zero-mode laser devices, and supersymmetry (SUSY), which holds the potential for achieving phase locking in laser arrays. In this work, we show that the relation between supersymmetric coupled bosonic and fermionic oscillators on one side, and bipartite networks (and hence chiral symmetry) on another side can be exploited together with non-Hermitian engineering for building one- and two-dimensional laser arrays with in-phase synchronization. To demonstrate …
Development Of New Controller And Associated Cybersecurity Issues With Battery Energy Storage Integrated With Microgrid, Syeda Afra Saiara
Development Of New Controller And Associated Cybersecurity Issues With Battery Energy Storage Integrated With Microgrid, Syeda Afra Saiara
Electronic Theses and Dissertations Archive
Battery energy storage system (BESS) plays a crucial role in integrating renewable sources in microgrids. However, robust BESS controllers are needed to carry out this function properly. Existing controllers suffer from overshoots and slow convergence issues. This thesis proposes a novel Sigma Delta Modulation (SDM) controller for BESS in solar photovoltaic (PV) connected microgrids to address the limitations of existing controllers. The performance of SDM has been compared with that of the Proportional Integral (PI) and Fuzzy Logic based controllers. Also, the thesis addresses the cybersecurity issues in solar PV based microgrids. The Ensemble Learning technique and an Improved Ensemble …
Schedulability Analysis Of Multi-Phase Limited-Preemption Tasks, Benjamin Standaert
Schedulability Analysis Of Multi-Phase Limited-Preemption Tasks, Benjamin Standaert
McKelvey School of Engineering Graduate Student Theses & Dissertations
This work addresses hard real-time systems, in which tasks must be scheduled so that they are guaranteed to meet deadlines. In particular, when tasks execute across multiple domains with high preemption costs, the combined cost of these preemptions can cause the system to become unschedulable. The number of preemptions must therefore be bounded to limit the overall task execution time, while ensuring that task blocking times are small enough to allow the system to be schedulable. Prior work introduces the Multi-Phase Secure model, which describes a more exact version of this scenario, and an algorithm to determine schedulability of sporadic …
Codifying Domesticity: The Story Of The Recommended Minimum Requirements For Small Dwelling Construction Of 1923, The Housing Policy Of The Hoover Secretariat, And The Impact On American Residential Architecture, Noah Morris
Graduate School of Architecture & Urban Design Theses & Dissertations
During the nineteenth and twentieth centuries, fire disasters and health-safety issues led to the widespread adoption of building codes. While the National Board of Fire Underwriters published the National Building Code in 1905, the code did not maintain regulatory consistency across the nation. This lack of consistency across the nation and socio-economic factors contributed to a nation-wide housing shortage of a million units by 1919. During World War I, the government addressed the housing crisis through the United States Housing Corporation and Emergency Fleet Corporation, building public housing based on the ideals of the Garden City Movement.[1] Following the …
A Computational And Mathematical Approach To The Preclinical Development Of Alpha Emitting Radiopharmaceutical Therapies, Abdulaziz Said
A Computational And Mathematical Approach To The Preclinical Development Of Alpha Emitting Radiopharmaceutical Therapies, Abdulaziz Said
McKelvey School of Engineering Graduate Student Theses & Dissertations
Numerous candidate nuclides have been undergoing rigorous preclinical development in the pursuit of novel targeted therapies. Successful development of these drugs relies on the understanding of physiological impacts at the macro and micro scales, in addition to a scalable process for their production. Here, mathematical and computerized approaches have been developed to guide this preclinical development. In this report, two alpha emitting nuclides Pb-212 and Ra-223 are modeled. Radium-223 dichloride citrate a newly approved ion indicated for treatment of bone metastatic castrate resistant prostate cancer, irradiates lesions through targeted uptake in bone at sites of disease. We have undertaken the …