Digital Commons Network^™

Characterization Of Developmentally Downregulated Nfe2l3 In Retinal Ganglion Cell Survival And Axon Regeneration, Lucy Homer

Holster Scholar Projects

Retinal ganglion cells (RGCs) are central nervous system projection neurons essential for transmitting visual information from the eye to the brain. Damage to RGCs, caused by conditions such as glaucoma and traumatic optic neuropathy (TON), may lead to vision loss or blindness, as adult RGCs lack regenerative capacity. This study focuses on Nfe2l3 (Nrf3), a developmentally downregulated transcription factor known to mediate cellular responses to oxidative stress, a key pathological event following optic nerve injury. We hypothesized that overexpressing Nfe2l3 in RGCs would enhance their survival and promote axon regeneration after optic nerve crush (ONC) injury. To test this, we …

Importance Sampling To Learn Vasopressor Dosage To Optimize Patient Mortality In An Interpretable Manner, Anshul Rastogi

Holster Scholar Projects

Sepsis is a life-threatening organ dysfunction resulting from an improperly compensated bodily response to infection. There is a high urgency among clinicians to develop a set of real-time explainable treatment guidelines and tools to address the high mortality rate of sepsis patients. We present a reinforcement learning approach for vasopressor drug dosage in intensive care unit sepsis patients to achieve a better-than-expert treatment policy. We preserved interpretability with a prototype learning layer and learn actions in an off-policy manner with importance sampling. We evaluated our design on the MIMIC-IV deidentified electronic health record dataset with an 80%-20% training-validation split for …

Understanding The Influence Of Bone Marrow Endothelial Cells On Primary Human Megakaryocytic-Erythroid Progenitor Cell Fate, Vedaamrutha Reddy

Holster Scholar Projects

The human bone marrow is a complex microenvironment comprised of hematopoietic, stromal, and bone marrow endothelial cells (BMECs). This study builds on previous findings to explore the regulatory role of BMECs in influencing the expansion and lineage choice of megakaryocytic-erythroid progenitors (MEPs). Understanding these interactions has the potential to advance transfusion medicine and improve treatments for conditions like thrombocytopenia and anemia. Due to complications with isolating human BMEC, we transitioned to a murine model. Murine BMECs were isolated and magnetic cell separation was employed to enrich for endothelial cells (ECs), which were then cultured over a 20-day period using standard …

Assessing Safety Culture: Lessons From The Aviation Industry, Mirrette Gendi, Cheri L. Marcham, Michael O'Toole

Publications

SAFETY CULTURE has been a topic of debate in academia as much as it has been in the practice of various industries (Zohar, 2010). Although the concept and definition of safety culture and what it entails have consumed much of the debate, the assessment of safety culture has been the most controversial. Yet, on the academic level, the topic of monitoring and measuring safety culture has seen limited research that offers reliable and valid assessment tools (Goodheart & Smith, 2014), especially when compared to the importance of safety culture as a component of a safety management system (SMS).

Artificial Fiduciaries, Zhaoyi Li

Washington and Lee Law Review

The rapid development of technology in the last decade has affected all levels of society. Corporate governance has not been immune to these changes. In the future, Artificial Intelligence (“AI”) fiduciaries may be technologically capable of serving as independent corporate directors. This could be an effective way to address the challenge of the absence of truly independent directors in the traditional governance framework. Artificial fiduciaries could also offer a way to mitigate agency costs and improve overall corporate governance. However, traditional corporate law lacks solutions for coping with the integration of AI into corporate governance.

Currently, there is little scholarship …

The Initial Response Of Biodiversity Conventions To The Covid-19 Pandemic, Royal C. Gardner, Lauren Beames, Katherine Pratt

William & Mary Environmental Law and Policy Review

The COVID-19 pandemic disrupted the operations of global biodiversity conventions, requiring virtual meetings in place of in-person events. Yet the pandemic also highlighted the importance of biodiversity conservation as a mechanism to reduce the risk of zoonotic diseases, as the October 2020 report issued by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (“IPBES”) emphasized. Now that in-person, international meetings have resumed, this Article examines the extent to which four biodiversity conventions—the Agreement on the Conservation of African-Eurasian Migratory Waterbirds, the Ramsar Convention, the Convention on International Trade in Endangered Species, and the Convention on Biological Diversity—considered the nexus …

Expanding Emissions Markets To Reduce Agricultural Nitrogen Run-Off, Samantha Tweet, Amy Hardberger

William & Mary Environmental Law and Policy Review

Synthetic fertilizers have been critical in averting global food shortages; however, synthetic fertilizers and their production have led to numerous environmental harms, including greenhouse gas emissions, water pollution, and soil degradation.

Scientists are working on a new technology that will create a more efficient and less impactful fertilizer process, but the legal mechanisms to encourage widespread adoption and subsequent environmental benefits fall short. In the absence of regulation, market tools can encourage behavior change. If the pollution reduction by exchanging fertilizer is turned into a tradable asset, agricultural users can benefit financially, which lowers potential barriers to participation in a …

Historical Fire And Forest Structure In Western Dry Forests: Alternative Models, Controversies, And Management Plan Revision, Gordon Steinhoff

William & Mary Environmental Law and Policy Review

Management plan revision is currently underway for national forests in the Sierra Nevada Mountains of California, the Pacific Northwest, and other regions of the country under the U.S. Forest Service’s 2012 Planning Rule. With respect to dry ponderosa pine and mixed-conifer forests in the Sierra Nevada and Pacific Northwest, agency scientists and others claim that these forests were historically open and parklike, with primarily large, well-distributed trees, few smaller trees, and sparse underlying vegetation, leaf litter, and woody debris. Large, high-severity fire was rare. Fire exclusion since the early 1900s has led to the “densification” of these forests and unnatural …

Patent Your Passenger Pigeons: De-Extinction Technologies & Ramifications Of The Product Of Nature Doctrine, Tyler Brooks

William & Mary Environmental Law and Policy Review

Part I of this Note will provide a brief overview of the current methods and scientific breakthroughs that are actively being pursued by private actors (particularly the bioengineering company Colossal Biosciences) to make de-extinct creatures, establishing the crucial point that any technique used to create such an animal will inherently fall short of being able to replicate an extinct species with any one hundred percent accuracy. This section will then briefly speak as to why private actors are looking to invest in de-extinction technologies in the first place, setting out how de-extinction technologies might one day prove incredibly profitable for …

Does History Repeat Itself? Analyzing Montana's 2023 Draft Wolf Management Plan In Light Of Historical Misconceptions Of Wolves, Katelyn Jones

William & Mary Environmental Law and Policy Review

This Note intends to argue that Montana’s Draft Wolf Management Plan, when compared to other states’ plans, particularly Wisconsin’s, is inadequate because it contains many indicators of the antiquated societal bias that has plagued the wolf’s reputation for centuries. Part I begins with a historical overview of wolf hysteria and controversy beginning in Europe and extending to colonial America. Included in Part I is a specific focus on the treatment of wolves in Yellowstone and Montana during the early 1900s. Part I ends with an overview of the reintroduction of wolves into the [Greater Yellowstone Ecosystem] GYE and the success …

Write Free Or Die: Vol. 11, No. 01, Unh Writing Programs

Writing Program Newsletter

No abstract provided.

Assessing Fisher Population Dynamics Across New Hampshire, Tyler Olkkola

Inquiry Journal Fall 2024

Through extensive field work, Tyler evaluated fisher populations in New Hampshire to help inform management practices and conservation policies.

Cross-National Variations In Scientific Ethics: Exploring Ethical Perspectives Among Scientists In China, The Us, And The Uk, Di Di, Elaine Howard Ecklund

Sociology

This research explores the perspectives of academic physicists from three national contexts concerning their roles and responsibilities within the realm of science. Using a dataset comprised of 211 interviews with scientists working in China, the United States, and the United Kingdom, the study seeks to explain whether and in what manner physicists conceptualize scientific ethics within a global or national framework. The empirical findings bring to light disparities across nations in the physicists’ perceptions of what constitutes responsible mentorship and engagement in public service. These cross-national variations underscore the moral agency of physicists as they navigate the ethical standards embraced …

Sex Differences In Metabolic Adaptation In Infants With Cyanotic Congenital Heart Disease, Tina O Findley, Ana Carolina Palei, Kyung Serk Cho, Zhongming Zhao, Caleb Shi, Gouri Mahajan, Antonio Francesco Corno, Jorge Salazar, Louise Mccullough

Faculty, Staff and Student Publications

BACKGROUND: Female infants with congenital heart disease (CHD) face significantly higher postoperative mortality rates after adjusting for cardiac complexity. Sex differences in metabolic adaptation to cardiac stressors may be an early contributor to cardiac dysfunction. In adult diseases, hypoxic/ischemic cardiomyocytes undergo a cardioprotective metabolic shift from oxidative phosphorylation to glycolysis which appears to be regulated in a sexually dimorphic manner. We hypothesize sex differences in cardiac metabolism are present in cyanotic CHD and detectable as early as the infant period.

METHODS: RNA sequencing was performed on blood samples (cyanotic CHD cases, n = 11; controls, n = 11) and analyzed …

Food Science Affiliated Publications, University Of Arkansas, Fayetteville: Snapshot Of The Research Publications, Jeremy J. Smith, Lutishoor Salisbury

University Libraries Faculty Publications and Presentations

This report provides a snapshot of the research publications for authors affiliated with the Food Science department at the University of Arkansas, Fayetteville, for the period 2018-2023. It includes publications by material type; co-author characteristics; ranking of journals according to journal citation reports.

Crystal Archer: Profile Of The Newest Chbc Faculty Member, Danna Jaimes-Fajardo, Jeremy J. Smith, Lutishoor Salisbury

University Libraries Faculty Publications and Presentations

Presents the research profile of Crystal Archer, Assistant Professor, Chemistry and Biochemistry department. It highlights her research interests, education, and impact of her research.

Machine Learning For Automated Classification Of Lung Collagen In A Urethane-Induced Lung Injury Mouse Model, Khalid Hamad Alnafisah, Amit Ranjan, Sushant P. Sahu, Jianhua Chen, Sarah Mohammad Alhejji, Alexandra Noël, Manas Ranjan Gartia, Supratik Mukhopadhyay

Faculty Publications

Dysregulation of lung tissue collagen level plays a vital role in understanding how lung diseases progress. However, traditional scoring methods rely on manual histopathological examination introducing subjectivity and inconsistency into the assessment process. These methods are further hampered by inter-observer variability, lack of quantification, and their time-consuming nature. To mitigate these drawbacks, we propose a machine learning-driven framework for automated scoring of lung collagen content. Our study begins with the collection of a lung slide image dataset from adult female mice using second harmonic generation (SHG) microscopy. In our proposed approach, first, we manually extracted features based on the 46 …

Clark Magazine, Fall 2024, Clark University

Clark Magazine

The Fall 2024 edition of Clark Magazine. Clark Magazine is a twice-yearly publication primarily geared towards Clark University Alumni.

The cover story is 'Does the World Need Poets? Yes, historians and philosophers, too. But as the humanities evolve in the digital age, Clark is finding new ways to think, and research, and create'.

"Population Growth And Mexico's Production Of Family Planning Short Films," In Challenging Stories: Exploring The Intersections Between Health And The Humanities, Martha L. Espinosa

History Faculty publications

This chapter focuses on three family planning short films produced by the Mexican government. I interpret these films as an instrument to prompt the population to self-govern their reproduction. Relying on the definition of governmentality as “how modern forms of power and regulation achieve their full effects not by forcing people toward state-managed goals but by turning them into accomplices” (Agrawal 2005, 217), I argue that these short films sought to promote a new reproductive subjectivity among working-class urban and rural Mexicans. In other words, such reproductive subjectivity consisted of encouraging couples to have fewer children by promoting the idea …

Population And Distribution Of The Ashy Red Colobus Monkey In Community Forests In Biharamulo District, Northwestern Tanzania, Olivia W. Cox

Tanzania: Wildlife Conservation and Political Ecology

This study was conducted in November 2024 using active observation searches and geospatial surveys to collect data. A total of 0.404357 km2 in the three forests was canvassed, and 108 individuals were observed. The study aimed to estimate the population and distribution of Ashy red colobus monkeys in three community forests in Biharamulo District, Northwestern Tanzania, where no previous research on the Ashy red colobus has taken place. A Bayesian negative binomial model and negative binomial regression model were applied to these findings to estimate 180 individuals in the three forests, with 40, 47, and 93 individuals estimated to reside …

Effects Of Land-Use Types On Avian Functional Diversity In Kilimanjaro Region, Tanzania, Ava Joan Boettiger

Tanzania: Wildlife Conservation and Political Ecology

This research examined avian abundance and functional diversity across four human land uses— monoculture, mixed farming, rural, and urban areas—in the Kilimanjaro Region of Northern Tanzania. Conducted in November 2024, the study aimed to assess how different land-use types influence avian composition and functional diversity. A quasi-experimental design was employed, using purposive sampling to select study sites and systematic random sampling point counts to observe bird species present in each land-use type. A literature review was also conducted to classify species into families and categorize them into functional feeding guilds: predators, insectivores, frugivores, granivores, and nectarivores. Statistical analyses, including ANOVA, …

Net-Zero Requirements For Federal Oil & Gas Leases: A Durable Way For The Executive Branch To Curb Greenhouse Gas Emissions, Adam Fisher

Denver Law Review

The Biden Administration committed the United States to achieving net-zero emissions by 2050. Without congressional action on the issue, the Administration’s reach was limited. However, nearly a quarter of all U.S. greenhouse gas (GHG) emissions derive from fossil fuels produced under federal permits. Thus, because the executive branch has significant discretion in the oil and gas permitting process, commentators have suggested that an administration could unilaterally limit U.S. GHG emissions by (1) requiring new federal oil and gas leases to be carbon neutral or (2) updating the lease and permit terms for existing federal leases to require carbon neutrality. However, …

Spcl 7906: Instructional Interventions In Schools, Meg Farmer

Open Educational Resources

Policies regulating curriculum development and practices. School based curriculum evaluation and models of curriculum based assessment applied to instructional accommodations and assistive technologies. Differentiation of instruction and other curriculum modifications for all students including students with special needs and English Language Learners. Learning strategies and approaches to literacy instruction.

Academic Department Indicators: 2023-2024, Systems Intelligence And Data Analytics, University Of Nebraska At Omaha

Academic Department Indicators

The audience is the Academic Planning Council (APC), college and department heads, and faculty. The purpose is to report instructional productivity measures useful for making comparisons and observing trends. Selected departmental information in this report is submitted annually to the Delaware Study, a National Study of Instructional Costs and Productivity.

This Instructional Productivity information corresponds to the UNO state- and tuition-funded budget. The Supplemental Information at the end of the document provides counts and statistics for campus-wide programs embedded in most colleges. Only Dual Enrollment instruction is excluded from the productivity report since it is a fee-based instructional program for …

Fall 2024 Degree Summary, Systems Intelligence And Data Analytics, University Of Nebraska At Omaha

Enrollment Reports

No abstract provided.

Science Education News, Fall 2024, University Of Northern Iowa. Science Education Program.

Science Education News

Contents:

--- A Message from the Director
--- Faculty Profile: Kyle Gray
--- MA Science Education
--- Student Profiles: Emma Bopp, Wyatt Heideman, Jim Duff
--- Yager Science Education Resources & Outreach
--- Science Education Happenings
--- 2024-2025 Events
--- Alumni Info Request
--- Support UNI Science Education

Regulation And Function Of The Rna-Binding Protein Khsrp During Neuronal Development, Regeneration And Axonal Injury Response, Courtney Nicole Buchanan

Theses and Dissertations

Axons, which extend long distances from neuronal cell bodies, rely on localized mRNA translation to swiftly respond to extracellular stimuli and physiological states. This work investigates the mechanism underlying the RNA-binding protein KHSRP’s, axonal mRNA translation and regulatory pathways involved in neuronal growth and regeneration. Our results indicate that KHSRP deletion in mice leads to upregulation of growth-associated mRNAs linked to neuronal morphology and function, resulting in increased axon growth and altered memory consolidation. Indicating a critical role for KHSRP in neuronal development and function through post-transcriptional regulation (Chapter 2). Additionally, we show there is a rapid increase in axonal …

Challenges And Coping Strategies Among Caregivers Of Children With Cancer Receiving Care At A National Referral Hospital In Kenya, Doris Machaki, Albanus Kyalo Mutisya, Jostine Mutinda, Sherry Oluchina, Samwel Maina Gatimu

School of Nursing & Midwifery, East Africa

Background: The number of children diagnosed with cancer is expected to increase by 2050. The caring aspect of these children is usually left to members of the family, more so the mothers. Caregivers are usually faced with various challenges, such as financial issues, social stigma, and emotional and psychological issues. Caregivers use various coping strategies to manage the challenges they experience in the caring process, which can be positive or negative coping strategies.

Objective: To explore the challenges and coping strategies of caregivers of children with cancer receiving care at a national referral hospital in Kenya.

Methods: This study employed …

Remediation Technology And Study To Remove Nano-Pollutants From Wastewater, Lauretta Ngozi Ndu Nwagu

Dissertations (2016-Present)

Life on Earth depends on water, which also has a direct impact on climate, health, and economic growth. Water poverty, pollution, and scarcity are some of the environmental issues confronting our society today. Water pollution and water poverty are both measurable parameters. Water quality is measured by comparing its physical, chemical, and biological properties to a predefined standard. This study examines remediation techniques for removing nano-pollutants from human-generated wastewater. In order to satisfy the Environmental Protection Agency’s (EPA) standard, this technological approach utilizes gravity and a zero-carbon footprint for wastewater purification.

The research is designed with various pore sizes of …

Bioluminesence-Induced Photoredox Catalysis And Its Mechanisms, Dominic Jeffrey Bates

Theses and Dissertations

The bioluminescence-induced photoredox reaction (BIPR) is a novel methodology developed to overcome the limitations of photo-induced chemistry by initiating chemical work using bioluminescent Escherichia coli as a photon source. In industry, photochemistry is superseded by thermochemical reaction processes. Despite its massive potential, there are very few applications in industry for photochemistry. Unlike thermochemistry, reaction scale-ups are not as easy as simple dimensional increases in a reaction vessel due to the nature of light. This deficiency is seemingly overcome through the development of flow technologies; however, the overall yield of such methods remains incomparable with those utilizing thermochemistry. This thesis focuses …