Digital Commons Network^™

The Pace Of Life For Forest Trees, Lalasia Bialic-Murphy, Robert M. Mcelderry, Adriane Esquivel-Muelbert, Johan Van Den Hoogen, Pieter A. Zuidema, Oliver L. Phillips, Edmar Almeida De Oliveira, Patricia Alvarez Loayza, Esteban Alvarez-Davila, Luciana F. Alves, Vinícius Andrade Maia, Simone Aparecida Vieira, Lidiany Carolina Arantes Da Silva, Alejandro Araujo-Murakami, Eric Arets, Julen Astigarraga, Fabrício Baccaro, Timothy Baker, Olaf Banki, Jorcely Barroso, Lilian Blanc, Damien Bonal, Frans Bongers, Kauane Maiara Bordin, Roel Brienen, Marcelo Brilhante De Medeiros, José Luís Camargo, Felipe Carvalho Araújo, Carolina V. Castilho, Wendeson Castro

School of Geography, Earth and Environmental Sciences

Tree growth and longevity trade-offs fundamentally shape the terrestrial carbon balance. Yet, we lack a unified understanding of how such trade-offs vary across the world's forests. By mapping life history traits for a wide range of species across the Americas, we reveal considerable variation in life expectancies from 10 centimeters in diameter (ranging from 1.3 to 3195 years) and show that the pace of life for trees can be accurately classified into four demographic functional types. We found emergent patterns in the strength of trade-offs between growth and longevity across a temperature gradient. Furthermore, we show that the diversity of …

Romi: A Randomized Two-Stage Basket Trial Design To Optimize Doses For Multiple Indications, Shuqi Wang, Peter F Thall, Kentaro Takeda, Ying Yuan

Faculty, Staff and Student Publications

Optimizing doses for multiple indications is challenging. The pooled approach of finding a single optimal biological dose (OBD) for all indications ignores that dose-response or dose-toxicity curves may differ between indications, resulting in varying OBDs. Conversely, indication-specific dose optimization often requires a large sample size. To address this challenge, we propose a Randomized two-stage basket trial design that Optimizes doses in Multiple Indications (ROMI). In stage 1, for each indication, response and toxicity are evaluated for a high dose, which may be a previously obtained maximum tolerated dose, with a rule that stops accrual to indications where the high dose …

The Biological Significance Of Tumor Grade, Age, Enhancement, And Extent Of Resection In Idh-Mutant Gliomas: How Should They Inform Treatment Decisions In The Era Of Idh Inhibitors?, Martin J Van Den Bent, Pim J French, Daniel Brat, Joerg C Tonn, Mehdi Touat, Benjamin M Ellingson, Robert J Young, Johan Pallud, Andreas Von Deimling, Felix Sahm, Dominique Figarella Branger, Raymond Y Huang, Michael Weller, Ingo K Mellinghoff, Tim F Cloughsey, Jason T Huse, Kenneth Aldape, Guido Reifenberger, Gilbert Youssef, Philipp Karschnia, Houtan Noushmehr, Katherine B Peters, Francois Ducray, Matthias Preusser, Patrick Y Wen

Faculty, Staff and Student Publications

The 2016 and 2021 World Health Organization 2021 Classification of central nervous system tumors have resulted in a major improvement in the classification of isocitrate dehydrogenase (IDH)-mutant gliomas. With more effective treatments many patients experience prolonged survival. However, treatment guidelines are often still based on information from historical series comprising both patients with IDH wild-type and IDH-mutant tumors. They provide recommendations for radiotherapy and chemotherapy for so-called high-risk patients, usually based on residual tumor after surgery and age over 40. More up-to-date studies give a better insight into clinical, radiological, and molecular factors associated with the outcome of patients with …

Meningioma: International Consortium On Meningiomas Consensus Review On Scientific Advances & Treatment Paradigms For Clinicians, Researchers, And Patients, Michael Mcdermott

All Publications

Meningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and increased access to neuroimaging. While most exhibit nonmalignant behavior, a subset of meningiomas are biologically aggressive and are associated with treatment resistance, resulting in significant neurologic morbidity and even mortality. In recent years, meaningful advances in our understanding of the biology of these tumors have led to the incorporation of molecular biomarkers into their grading and prognostication. However, unlike other central nervous system (CNS) tumors, a unified molecular taxonomy for meningiomas has not yet been established and remains an …

In Acute Severe Ulcerative Colitis Patients Who Receive Rescue Therapy, Prior Maintenance Therapy And Day 3 C-Reactive Protein After Rescue Therapy Are Associated With 12-Month Colectomy Risk, Jared A Sninsky, Ana-Maria Staicu, Edward L Barnes

Faculty, Staff and Students Publications

No abstract provided.

A Ligation-Independent Sequencing Method Reveals Trna-Derived Rnas With Blocked 3′ Termini, Alessandro Scacchetti, Emily J Shields, Natalie A Trigg, Grace S Lee, Jeremy E Wilusz, Colin C Conine, Roberto Bonasio

Faculty, Staff and Students Publications

Despite the numerous sequencing methods available, the diversity in RNA size and chemical modification makes it difficult to capture all RNAs in a cell. We developed a method that combines quasi-random priming with template switching to construct sequencing libraries from RNA molecules of any length and with any type of 3' modifications, allowing for the sequencing of virtually all RNA species. Our ligation-independent detection of all types of RNA (LIDAR) is a simple, effective tool to identify and quantify all classes of coding and non-coding RNAs. With LIDAR, we comprehensively characterized the transcriptomes of mouse embryonic stem cells, neural progenitor …

October 3, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Immune Checkpoint Inhibitors In The Management Of Brain Metastases From Non-Small Cell Lung Cancer: A Comprehensive Review Of Current Trials, Guidelines And Future Directions, Arun Maharaj, Manmeet Ahluwalia

All Publications

Background: Brain metastases (BM) are a common, severe complication in patients with non-small cell lung cancer (NSCLC) and are difficult to treat due to their complex tumor biology and the intricate microenvironment of the brain.

Objectives: This review examines the current role of immune checkpoint inhibitors (ICIs) in treating NSCLC with BM, focusing on the latest clinical trials, emerging strategies, current guidelines, and future directions. We highlight the efficacy of ICIs as monotherapy and in combination with other treatments such as radiotherapy, stereotactic radiosurgery, chemotherapy, and anti-VEGF agents.

Results: While no single treatment sequence is universally accepted, combining ICIs with …

Leptomeningeal Metastases From Solid Tumors: A Society For Neuro-Oncology And American Society Of Clinical Oncology Consensus Review On Clinical Management And Future Directions, Jessica A Wilcox, Ugonma N Chukwueke, Myung-Ju Ahn, Ayal A Aizer, Tejus A Bale, Dieta Brandsma, Priscilla K Brastianos, Susan Chang, Mariza Daras, Peter Forsyth, Livia Garzia, Michael Glantz, Isabella C Glitza Oliva, Priya Kumthekar, Emilie Le Rhun, Seema Nagpal, Barbara O'Brien, Elena Pentsova, Eudocia Quant Lee, Jan Remsik, Roberta Rudà, Inna Smalley, Michael D Taylor, Michael Weller, Jeffrey Wefel, Jonathan T Yang, Robert J Young, Patrick Y Wen, Adrienne A Boire

Faculty, Staff and Students Publications

Leptomeningeal metastases (LM) are increasingly becoming recognized as a treatable, yet generally incurable, complication of advanced cancer. As modern cancer therapeutics have prolonged the lives of patients with metastatic cancer, specifically in patients with parenchymal brain metastases, treatment options, and clinical research protocols for patients with LM from solid tumors have similarly evolved to improve survival within specific populations. Recent expansions in clinical investigation, early diagnosis, and drug development have given rise to new unanswered questions. These include leptomeningeal metastasis biology and preferred animal modeling, epidemiology in the modern cancer population, ensuring validation and accessibility of newer leptomeningeal metastasis diagnostics, …

Who’S Actually Afraid Of Artificial Intelligence (Ai?), Anthony Adeloye

Library Philosophy and Practice (e-journal)

Purpose of the study: The main purpose of the study is to explore and discuss the views of a group of Nigerian academic librarians about Artificial Intelligence (AI). The study is considered important because a perusal of an academic librarian’s role requires the ability to organise and manage knowledge which invariably entails the use of some sort of technology which in the context of this study, is artificial intelligence (AI).

Method: To understand the degree to which academic librarians in Nigeria perceive the role of AI in academia, and indeed, society, data were collected from an online survey that …

Inflammation-Induced Epigenetic Imprinting Regulates Intestinal Stem Cells, Dongchang Zhao, Visweswaran Ravikumar, Tyler J Leach, Daniel Kraushaar, Emma Lauder, Lu Li, Yaping Sun, Katherine Oravecz-Wilson, Evan T Keller, Fengju Chen, Laure Maneix, Robert R Jenq, Robert Britton, Katherine Y King, Ana E Santibanez, Chad J Creighton, Arvind Rao, Pavan Reddy

Faculty, Staff and Students Publications

It remains unknown whether, and how intestinal stem cells (ISC) adapt to inflammatory exposure, and if the adaptation leaves scars will affect their subsequent regeneration. We investigated the consequences of inflammation on Lgr5+ISCs in well-defined clinically relevant models of gastrointestinal acute graft-versus-host disease (GI GVHD). Utilizing single cell transcriptomics, organoid, metabolic, epigenomic and in vivo models we found that Lgr5+ISCs undergo metabolic changes that lead to accumulation of succinate, which reprograms its epigenome. These changes reduced the ability of ISCs to differentiate and regenerate ex vivo in serial organoid cultures and also in vivo following serial transplantation. Furthermore, ISCs demonstrated …

October 3, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Anti-Fungal Greenhouse Screen And System With An Anti-Fungal Greenhouse Screen, Treier Ip Services

Defensive Publications Series

The present invention concerns a foldable or static screen for greenhouses. The screen has anti-fungal properties, improving the longevity of the product and preventing cross-contamination of products grown in the greenhouse with fungi.

Linfield Digest, Linfield Magazine Staff

Linfield Magazine

Brief articles and photos of events and news about Linfield University

Called: A Pentecostal Theology Of Vocation, Martin W. Mittelstadt

Spiritus: ORU Journal of Theology

In this essay, I propose a Pentecostal theology of vocation that extends out of the Full Gospel and prophethood of all believers. Though Pentecostals devote considerable attention to church-related/religious vocations, Pentecostals must reimagine vocational implications for fullness of the Spirit on all believers. All Pentecostals are called to embody the dual impulses of the Fivefold Gospel. They are being saved, sanctified, baptized in the Spirit, healed, and living in eager anticipation of Jesus’ return. At the same time, all Pentecostals become saving agents with Christ; they perform holy love; they engage in Spirit-inspired witness; they offer healing balm for a …

Varieties Of Healing: A Catholic Perspective, Andrew Prevot

Spiritus: ORU Journal of Theology

This article contributes to Catholic-Pentecostal ecumenical dialogue by offering a particular Catholic perspective on the shared Christian belief in Christ is the Healer. More specifically, it distinguishes several ways in which humans are called to participate in the healing work of Christ. It considers Catholic approaches to sacramental, charismatic, miraculous, biomedical, psychotherapeutic, social, and ecological healing. It reflects on the historical background, contemporary significance, and interconnections of these diverse areas of healing, while distinguishing such a holistic understanding of healing from the narrower concept of a cure. Acknowledging the problem of unhealed sufferers, it argues against blaming such persons for …

Phytochemical Profiling And Antioxidant Potential Of Methanol Extract Of Vitis Vinifera L Seeds., Sindhuja Lakshmi, Kesavaram Padmavathy Dr, Thirunavukarasu Umaarasu Dr, Dhandapani Prabu Dr

Chulalongkorn Medical Journal

Background: Grapes are the most widely consumed fruit around the world. Grape seed comprises a group of polyphenols are known to have a broad pharmacological and therapeutic activities. The grape seed extract was known to have counteract against oxidative stress by its free radical scavenging activity.

Objectives: To identify the major phytocompounds of grape seed methanol extract and to evaluate its antioxidant activity

Methods: In this study, the methanol extract of the grape seed was subjected to Gas Chromatography-Mass Spectrometry to identify the major phytochemical compounds and further antioxidant activity was also evaluated by DPPH method using AOAC (Association of …

Diversity Of Porifera Along The Coasts Of Türkiye, Alper Evcen, Bülent Topaloğlu

Turkish Journal of Zoology

This study compiled data on the distribution of sponge species on the coasts of Türkiye. The checklist consists of 183 speciesbelonging to 52 families, 16 orders, and 3 classes. The orders Haplosclerida (32 species), Poecilosclerida (28 species), Tetractinellida (26species), Dictyoceratida (21 species), and Suberitida (18 species) have the highest numbers of species found in the region. The Aegeancoast has the highest number of sponge species (155 species), followed by the Sea of Marmara (84 species), the Levantine coast (50species), and the Black Sea coast (24 species). Among the species, Niphates toxifera and Paraleucilla magna are alien species. A total of …

Diversity Of Cnidaria And Ctenophora From The Coasts Of Türkiye, Meli̇h Ertan Çinar, Şermi̇n Açik, Hali̇m Vedat Aker

Turkish Journal of Zoology

The compilation of papers on the phyla Cnidaria and Ctenophora inhabiting the coasts of Türkiye (Black Sea, Sea of Marmara,Aegean Sea, and Levantine Sea) together with the new records of cnidarian species presented in this study yielded 296 cnidarian and8 ctenophore species. Among the cnidarian groups, Hydrozoa were represented by 160 species, Scyphozoa by 16 species, Anthozoa by87 species, and Myxozoa by 31 species. The number of species of cnidarians and ctenophores varies greatly between regions due to thedifferent environmental conditions of the seas and the level of scientific effort in each sea. A total of 47 cnidarian and five …

Diversity Of Annelida From The Coasts Of Türkiye, Meli̇h Ertan Çinar, Şermi̇n Açik, Güley Kurt, Deni̇z Erdoğan Dereli̇

Turkish Journal of Zoology

The compilation of scientific papers dealing with marine annelids (including Sipuncula) along the coasts of Türkiye (Black Sea, Sea of Marmara, Aegean Sea and Levantine Sea) together with the new records of polychaete species (22 species) presented in this study resulted in 827 species belonging to 63 families. Polychaeta were represented by 782 species, Sipuncula by 21 species, Oligochaeta by 18 species, Hirudinea by 5 species and Echiura by 1 species. Syllidae (127 species), Spionidae (57 species) and Serpulidae (56 species) were the most species-rich families and their numbers varied among the seas. Most annelid species were benthic (808 species), …

Diversity Of Fishes Along The Coast Of Türkiye, Murat Bi̇lecenoğlu

Turkish Journal of Zoology

The Turkish marine fish diversity was revised and updated in this study based on data published in the last decade. There arecurrently 552 species in the inventory, reflecting an increase of 7.8% since the previous checklist and belonging to the classes of Teleostei(479 spp.), Elasmobranchii (68 spp.), Chondrostei (3 spp.), Petromyzonti (1 sp.), and Holocephali (1 sp.). Twelve species were excludedfrom the faunal list due to the lack of valid proof of their presence, the distribution ranges of an additional 12 species were corrected, twonew records (Istiompax indica (Cuvier, 1832) and Mola alexandrini (Ranzani, 1839)) previously unknown from Türkiye were …

Diversity Of Marine Tetrapods (Reptiles, Seabirds, And Mammals) Along The Coasts Of Türkiye, Harun Güçlüsoy, Ortaç Onmuş

Turkish Journal of Zoology

This paper presents the occurrence of a total of 72 marine tetrapod species, comprising 3 sea turtles, 54 seabirds, and 15 marine mammals. The distribution of each reported species along the Black Sea, Sea of Marmara, Aegean, and Levantine coasts of Türkiye is described with key references.

Presentation And Study Of The Manuscript Entitled “The Sign Of Happiness In Habitual Foods By Doctor Abu Al-Hasan Ali Ibn Hassan Al-Marakshi”, Abdelhamid Bitari, Rachid Touzani, Belkheir Hammouti, Abdelkhaleq Legssyer

An-Najah University Journal for Research - B (Humanities)

Introduction: Morocco preserves manuscripts of significant scientific and cultural value, which require presentation, verification, and study. The importance of studying the book "The Sign of Happiness in Common Foods" lies in the fact that it serves as a scientific reference point for understanding the principles of nutrition and medicinal herbs during the Middle Ages, especially in the Islamic world. Objective: Manuscript books represent a cultural and scientific treasure for Moroccan and humanity civilizations. Therefore, they require uncovering, displaying, and studying. Our work in this context involves presenting and studying the manuscript book titled "The Sign of Happiness in Usual Foods …

Diversity Of Bryozoa Along The Coasts Of Türkiye, Ferah Koçak, Si̇nem Aydin

Turkish Journal of Zoology

The current status of bryozoan species distributed along the coast of Türkiye were revised and an updated checklist including 185 species (24 cyclostomatids, 20 ctenostomatids and 141 cheilostomatids) was presented. Cheilostomes largely prevail (141 species, 87 genera and 50 families) followed by cyclostomes (24 species, 15 genera and 9 families) and ctenostomes (20 species, 9 genera and 8 families) in bryozoan fauna of Türkiye. The distribution of species and genera highlights the Aegean Sea as the most diverse, hosting 146 species. In this study, Hornera frondiculata (Lamarck, 1816), Amathia verticillata (delle Chiaje, 1822), Bugulina fulva (Ryland, 1960), Tricellaria inopinata d'Hondt …

Coyotes Can Do ‘Puppy Dog Eyes’ Too: Comparing Interspecific Variation In Canis Facial Expression Muscles, Patrick Cunningham, Mahita Shankar, Bridgett Vonholdt, Kristin Brzeski, Sarah S. Kienle

Michigan Tech Publications

Facial expressions are critical for non-verbal communication. The Canis genus epitomizes the interplay between behaviour and morphology in the evolution of non-verbal communication. Recent work suggests that the levator anguli oculi medialis (LAOM) muscle is unique to dogs (Canis familiaris) within the Canis genus and evolved due to domestication. The LAOM raises the inner eyebrows, resulting in the ‘puppy dog eyes’ expression. Here, we test whether the LAOM is a derived trait in dogs by (i) examining the facial expression muscles of a closely related and ancestral wild Canis species, the coyote (C. latrans) and (ii) comparing our results with …

Commonwealth Times 2024-10-02

Commonwealth Times, 1969-

No abstract provided.

Complete Issue, Journal Editors

Venture: The University of Mississippi Undergraduate Research Journal

No abstract provided.

Front Matter, Journal Editors

Venture: The University of Mississippi Undergraduate Research Journal

No abstract provided.

In-Situ, High-Throughput Dna Sequencing And Methodology Refinement To Survey Biodiversity And Identify Candidate New Species To Science In A Largely Unprotected Biological Corridor In Ecuador, Christian Boudreaux

Venture: The University of Mississippi Undergraduate Research Journal

The world is undergoing a biodiversity crisis in which hundreds of species have gone extinct within the last few centuries, rivaling previous mass extinction events that have only occurred five times in the history of the planet. Anthropogenic stressors such as the climate crisis, over exploitation of natural resources, deforestation, and pollution have created and fostered a mass extinction event that is taking place in every corner of the planet. Endemic species, those that are hyper-specialized to specific environmental conditions are most at risk of going extinct. Endemism, therefore, is used as a tool for conservation and as an indicator …

Urine-Derived Stem Cells Detect Renal Mitochondrial Toxicity In Hiv Patients Receiving Antiretroviral Therapy, Daniella Beiner, Yu Pengfei, Hainan Zhu, Carol C. Bosholm, Yuanyuan Zhang

Venture: The University of Mississippi Undergraduate Research Journal

Antiretroviral therapy (ART) has significantly improved the clinical outcomes of patients infected with human immunodeficiency virus (HIV). However, long-term use of certain antiretroviral drugs has been associated with renal mitochondrial toxicity (MtT), leading to potentially severe renal dysfunction. To date, there is no available test for renal MtT. Urine-derived stem cells (USCs) have emerged as a valuable non-invasive tool for studying renal pathology. In this study, we examine the effects of antiretroviral drugs on mitochondrial function in USCs from HIV patients as a first step towards establishing USCs as a tool for renal mitochondrial toxicity testing. USCs were isolated from …