Digital Commons Network^™

Honey Targets Ribosome Biogenesis Components To Suppress The Growth Of Human Pancreatic Cancer Cells, Aun A. Bangash, Sahir S. Alvi, Muhammad Bangash, Haider Ahsan, Shiza Khan, Rida Shareef, Georgina Villanueva, Divyam Bansal, Mudassier Ahmad, Dae Joon Kim, Subhash Chauhan, Bilal B. Hafeez

School of Medicine Publications

Simple Summary

Pancreatic cancer (PanCa) is one of the deadliest forms of cancer with limited therapeutic options. The available conventional therapies are highly toxic and often show resistance. Accumulating evidence suggests that dysregulated ribosome biogenesis has been linked to the survival and aggressive phenotypes of many tumor types, including PanCa. Thus, targeting ribosome biogenesis could be a novel approach for suppressing the growth of PanCa. The current study aimed to investigate the anti-cancer efficacy and underlying molecular mechanisms of honey against PanCa. Our results demonstrated that honey induces apoptosis and inhibits the growth and invasive potential of PanCa cells by …

Symposium: What Does The Microbiome Tell Us About Prevention And Treatment Of Ad/Adrd?, Joia K Capocchi, Claudia Figueroa-Romero, Sage J B Dunham, Gina Faraci, Jason A Rothman, Katrine L Whiteson, Dong-Oh Seo, David M Holtzman, Stefanie Grabrucker, Yvonne M Nolan, Rima Kaddurah-Daouk, David A Jett

2020-Current year OA Pubs

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota-gut-brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.

A Review Of Biomass-Based Natural Coagulants For Water Pollution Remediation: Impact Of Properties And Coagulation Operational Parameters, Nur Faizzah Husna Mohammad Ali, Megat Ahmad Kamal Megat Hanafiah, Sabiha Hanim Saleh, Mohd Tajudin Mohd Ali, Shariff Ibrahim

AUIQ Complementary Biological System

The rapid growth of cities, industries, and population has made tackling water scarcity increasingly challenging as the global demand for clean drinking water continues to rise. Consequently, extensive research in water and wastewater treatment, specifically focusing on the coagulation process, has ensued. Coagulation plays a critical role in water treatment, and its effectiveness depends on the type of coagulant used. However, the widespread use of chemical coagulants raises concerns for the environment and public health. Consequently, there has been growing interest in exploring natural alternatives derived from plants and animals. This review examines how the properties of natural coagulants, as …

Crafting Lornoxicam-Infused Microsponges For Elevated Efficacy In Inflammatory Disorders, Vishal Yadav, Pooja Kachare

Bulletin of Faculty of Pharmacy Cairo University

Introduction: Lornoxicam (LRX), a member of the Oxicam class of non-steroidal anti-inflammatory drugs (NSAIDs), exhibits potent analgesic, anti-inflammatory, and antipyretic properties. Nevertheless, its effectiveness is hampered by high dosage requirements, a short half-life, and low and pH dependent water solubility, necessitating further research for enhanced therapeutic outcomes.

Methodology: This study introduces floating microsponges of LRX to enhance drug release duration and reduce dosing frequency. Microsponges were formulated using quasi-emulsion solvent diffusion with ethyl cellulose and polyvinyl alcohol (PVA) as sustained-release polymers. A 3² factorial design assessed the effects of ethyl cellulose (X₁) and PVA (X₂) …

Vol. 28, No. 5 - Whole No. 131, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Mutations And Antibiotic Resistance In Mycobacterium Tuberculosis, Ryan M. Johnson, Bodhi Brady, Nicklaus Busse, Connor Beckman, Hunter Gloden, Joseph Glasrud, Zachary Smith, Hari P. Nepal, Madhav P. Nepal

Life Science Reports

Mycobacterium tuberculosis (MTB) is a bacterium known to target, infect, and destroy lung cells as well as connective tissues within the body. This bacterium is prevalent worldwide and has infected over a quarter of the current world population, becoming one of the most successful pathogens in history. Due to its extreme transmission rates as an airborne pathogen, MTB strains have been treated with antibiotics such as rifampicin and isoniazid, which inhibit bacterial infection in the human body. These first-round drugs remained as successful mechanisms for slowing and killing the pathogen, notably through rifampicin's inhibition of RNA-polymerase and isoniazid’s ability to …

Prescription Adherence Rates Across Medication Categories, Makenzie Stagner, Allie Weber, Madhav P. Nepal, Hari P. Nepal

Life Science Reports

Prescription adherence is a major public health challenge, as non-adherence to medication instructions can lead to poorer health outcomes and higher healthcare costs. Although prescription adherence is crucial for managing patient compliance and health outcomes, adherence rates differ greatly between medication types. The main objectives of this study were to determine prescription adherence rates across six medication types (antibiotic, cardiac, chronic health, pediatric, and psychiatric) and identify sources of variation. We searched PubMed and Web of Science databases for relevant published articles. Previous research data were selected related to prescription adherences and compliance rates were included in our analysis. Results …

Viewing Adhd’S Impact On Children’S Social Development Through The Lens Of Peer Rejection, Bethany Sycamore

Family Perspectives

No abstract provided.

Cover And Front Matter

Research and Reflection on Learning and Teaching in Higher Education

No abstract provided.

Lgbtqia2s+ Inclusive Language (Handout), Elizabeth Banks

Justice Festival at Morehead State University

A handout for the presentation, titled "LGBTQIA2S+ Inclusive Language," given by Elizabeth Banks at the Justice Festival held on the campus of Morehead State University on October 8, 2024.

An Interview With Harry “Murf” Mccloy, Harry (Murf) Mccloy

The Journal of Conventional Weapons Destruction

Harry “Murf” McCloy, is a retired US Marine Colonel who transitioned from military service to become a pivotal figure in humanitarian demining with PM/WRA in the US Department of State. Heading the US State Department’s first demining program in Bosnia and Herzegovina in 1996, McCloy became the State Department’s Senior Demining Advisor in 1998, holding this position until his retirement in 2007. He continues to work parttime in the Office of Weapons Removal and Abatement and has played a crucial role in the strategic oversight and execution of mine action programs across forty-six countries, significantly enhancing safety and establishing essential …

No Silver Bullet: Environment And Climate Funding In Mine Action, Christelle Mestre

The Journal of Conventional Weapons Destruction

Funding requirements, needs, and models are evolving to reflect the growing focus on environment and climate considerations in the mine action sector. This article examines current funding practices for environmental considerations within the sector and beyond, emphasizing the need for a holistic approach that looks at the broader impact of mine action. It underscores the importance of strategic partnerships, national mine action strategies, and awareness-raising efforts among donors and investors about the environmental and climate-related benefits of mine action. The article argues that while there’s no silver bullet, the integration of environmental and climate considerations into mine action can secure …

Binding Mechanism Of The Active Form Of Molnupiravir To Rdrp Of Sars-Cov-2 And Designing Potential Analogues: Insights From Molecular Dynamics Simulations., Justin Carbone, Nicholas J Paradis, Dylan Brunt, Chun Wu

College of Science & Mathematics Departmental Research

Molnupiravir, an FDA-approved nucleoside prodrug for treating COVID-19, converts into N4-hydroxycytidine triphosphate (NHC-TP), which integrates into SARS-CoV-2 RNA by its RNA-dependent RNA polymerase (RdRp) causing lethal mutations in viral proteins. Due to the risk of RdRp-mediated drug resistance and potential off-target effects on host polymerases (e.g., human polymerase II/HPolII), it is crucial to understand NHC-TP interactions at polymerase active sites for developing new, resistance-proof treatments. In this study, we used molecular dynamics (MD) simulations to probe key interactions between NHC-TP and SARS-CoV-2 RdRp and designed novel NHC-TP analogues with greater selectivity for SARS-CoV-2 RdRp over HPolII by a virtual screening …

Crocodylian Diversity During The Early Eocene Climatic Optimum In The Golden Valley Formation Of North Dakota, U.S.A., Adam P. Cossette, David Tarailo

Biological Sciences Faculty Publications

Rich bone beds from the lower Eocene strata of the Golden Valley Formation of Stark County, North Dakota reveal a speciose sympatric crocodylian fauna. However, analyses demonstrate limited phylogenetic diversity among these co-occurring taxa, and of the four species known for the locality, three are alligatorids and one is a crocodyloid. Phylogenetic hypotheses recover Chrysochampsa mylnarskii as a late lived member of Brachychampsini—a stem-based clade including Brachychampsa montana and all alligatorids more closely related to it than to Caiman crocodilus or Alligator mississippiensis—and a new genus and species, Ahdeskatanka russlanddeutsche groups with species of Allognathosuchus. The crocodylians, partitioned by body …

Brownfield Topsoil Vertical Heterogeneity: Implications For Germination And Soil Microbial Functioning, Eshariah N. Dyson, Diane F. Hagmann, Cesar Idrovo, Jennifer Adams Krumins, Nina M. Goodey

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Soil vertical heterogeneity refers to the variation in soil properties and composition with depth. In uncontaminated soils, properties including the organic matter content and nutrient concentrations typically change gradually with depth due to natural processes such as weathering, leaching, and organic matter decomposition. In contaminated soils, heavy metals and organic contaminants can migrate vertically through leaching or root uptake and translocation by plants and macrobiota, if present, leading to vertical heterogeneity in contaminant concentrations at different depths. Contaminants can alter soil properties, and we investigated the implications of soil vertical heterogeneity for germination and microbial functioning. We collected soil from …

Ai And Future-Making: Design, Biases, And Human-Plant Interactions, Maliheh Ghajargar

Art Faculty Articles and Research

Design researchers and practitioners are turning to generative AI (genAI) to support activities such as ideation and concept development in pursuit of preferred futures. At the same time, genAI is known to have biases, which prompts questions about how these biases might adversely affect design practices. In the domain of sustainable HCI, with its recent trends in human-nature interactions and more-than-human design, the question can be further refined into whether and how genAI biases might perpetuate anthropocentric biases that these practices are increasingly seeking to confront. In the present research, we conducted three workshops, focusing on genAI for human-plant interactions; …

"The Words We Do Not Yet Have." A Creative Inquiry Into Human-Plant Relationships, Maliheh Ghajargar

Art Faculty Articles and Research

Climate change, loss of plant biodiversity, and ocean pollution signal the drastic changes in our ecology that call us to attend to the needs of more than human forms of life on Earth. Sustainable design and HCI research are responding to this call by offering methods and approaches to design more sustainable products and systems and recently, more than human design is building momentum. This agenda seeks to reform traditional design processes by decentering the creative agency of the dominant socio-economical group of humans and foregrounding those of diverse Others. In this paper, I focus on plants as a nonhuman …

Rapid Unleashing Macrophage Efferocytic Capacity By Transcriptional Pause Release, Turan Tufan

Arts & Sciences Graduate Student Theses and Dissertations

During development, inflammation or tissue injury, macrophages engulf multiple apoptotic cells via efferocytosis to maintain tissue homeostasis. The mechanism by which macrophages rapidly adapt their transcription for continuous corpse uptake is not well understood. Transcriptional pause/release is a conserved mechanism, in which RNA polymerase (Pol) II initiates transcription for 20-60 nucleotides, is paused for minutes to hours and is then released to the elongation phase. We show that macrophages quickly use Pol II pause/release upon encountering corpses to trigger a rapid transcriptional response. This mechanism is essential for continuous efferocytosis but does not affect other forms of phagocytosis. Genomic data …

Rapid Unleashing Macrophage Efferocytic Capacity By Transcriptional Pause Release, Turan Tufan

Arts & Sciences Graduate Student Theses and Dissertations

During development, inflammation or tissue injury, macrophages engulf multiple apoptotic cells via efferocytosis to maintain tissue homeostasis. The mechanism by which macrophages rapidly adapt their transcription for continuous corpse uptake is not well understood. Transcriptional pause/release is a conserved mechanism, in which RNA polymerase (Pol) II initiates transcription for 20-60 nucleotides, is paused for minutes to hours and is then released to the elongation phase. We show that macrophages quickly use Pol II pause/release upon encountering corpses to trigger a rapid transcriptional response. This mechanism is essential for continuous efferocytosis but does not affect other forms of phagocytosis. Genomic data …

The Role Of Group 2 Innate Lymphoid Cells In Restoring Lung Health And Chitinase Function After Epithelial Injury, Haerin Jung

Arts & Sciences Graduate Student Theses and Dissertations

Alveolar epithelial cells provide oxygen transport and act as a first line of defense against pathogens and environmental triggers that disturb tissue homeostasis. However, in the context of epithelial injury, fibrotic and inflammatory lung diseases develop where regenerative responses may become dysregulated or recurrently engaged. One cause of lung injury is infection with cytopathic respiratory viruses such as influenza and SARS-CoV-2 viruses, which induce lung inflammation, tissue damage, and epithelial cell injury and loss. Restoration of barrier integrity after lung injury is critical for re-establishing healthy lung function but the underlying mechanisms are unclear. In the steady state, lung epithelial …

The Role Of Group 2 Innate Lymphoid Cells In Restoring Lung Health And Chitinase Function After Epithelial Injury, Haerin Jung

Arts & Sciences Graduate Student Theses and Dissertations

Alveolar epithelial cells provide oxygen transport and act as a first line of defense against pathogens and environmental triggers that disturb tissue homeostasis. However, in the context of epithelial injury, fibrotic and inflammatory lung diseases develop where regenerative responses may become dysregulated or recurrently engaged. One cause of lung injury is infection with cytopathic respiratory viruses such as influenza and SARS-CoV-2 viruses, which induce lung inflammation, tissue damage, and epithelial cell injury and loss. Restoration of barrier integrity after lung injury is critical for re-establishing healthy lung function but the underlying mechanisms are unclear. In the steady state, lung epithelial …

A Comparison Of Gaussian Processes And Polynomial Chaos Emulators In The Context Of Haemodynamic Pulse–Wave Propagation Modelling, L. Mihaela Paun, Mitchel J. Colebank, Dirk Husmeier

Faculty Publications

Computational modelling of the cardiovascular system is a promising future direction for patient-specific healthcare. However, the computational cost of these simulators is a bottleneck for their practical use in clinic for real-time digital twins. Emulation can overcome this, yet an extensive investigation into cardiovascular emulators is warranted. In this study, we emulate two one-dimensional haemodynamics models of the pulmonary circulation and compare two common emulation strategies: Gaussian processes (GPs) and polynomial chaos expansions (PCEs). We start by reducing the parameter space of the models through global sensitivity analysis, and then compare both emulation strategies using a multivariate, time-series output …

Challenges And Future Directions In Quantifying Terrestrial Evapotranspiration, Koong Yi, Gabriel B. Senay, Joshua B. Fisher, Lixin Wang, Kosana Suvočarev, Housen Chu, Georgianne W. Moore, Kimberly A. Novick, Mallory L. Barnes, Trevor F. Keenan, Kanishka Mallick, Xiangzhong Luo, Justine E. C. Missik, Kyle B. Delwiche, Jacob A. Nelson, Stephen P. Good, Xiangming Xiao, Steven A. Kannenberg, Arman Ahmadi, Tianxin Wang, Gil Bohrer, Marcy E. Litvak, David E. Reed, A. Christopher Oishi, Margaret S. Torn, Dennis Baldocchi

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Terrestrial evapotranspiration is the second-largest component of the land water cycle, linking the water, energy, and carbon cycles and influencing the productivity and health of ecosystems. The dynamics of ET across a spectrum of spatiotemporal scales and their controls remain an active focus of research across different science disciplines. Here, we provide an overview of the current state of ET science across in situ measurements, partitioning of ET, and remote sensing, and discuss how different approaches complement one another based on their advantages and shortcomings. We aim to facilitate collaboration among a cross-disciplinary group of ET scientists to overcome the …

Genetic Diversity Of Soybean Dwarf Virus In Two Regions Of Mainland Australia, Benjamin S. Congdon, Murray Sharman, Monica Kehoe

Biosecurity Research Articles

Soybean dwarf virus (SbDV; family Tombusviridae, genus Luteovirus, species Luteovirus glycinis) is an RNA plant virus that is transmitted solely by aphids in a persistent, circulative and non-propagative manner. SbDV causes significant losses in cultivated Fabaceae, especially in subterranean clover (Trifolium subterraneum) pastures of mainland Australia. SbDV isolates are classified into four phenotypically distinguishable strains: YP, YS, DP, and DS. Y and D strains differ primarily in their host range, and P and S strains in their primary vector species. Genetically, Y and D strains separate into two clades in every genomic region except for …

The Role Of Lymph-Adipose Crosstalk In Alcohol-Induced Perilymphatic Adipose Tissue Dysfunction, Kourtney D. Weaver, Liz Simon, Patricia E. Molina, Flavia Souza-Smith

School of Graduate Studies Faculty Publications

Chronic alcohol use leads to metabolic dysfunction in adipose tissue. The underlying mechanisms and the contribution of alcohol-induced adipose tissue dysfunction to systemic metabolic dysregulation are not well understood. In our previous studies, we found that chronic alcohol feeding induces mesenteric lymphatic leakage, perilymphatic adipose tissue (PLAT) inflammation, and local insulin resistance in rats. The goal of this study was to further explore the link between alcohol-induced lymphatic leakage and PLAT immunometabolic dysregulation, locally and systemically, using in vivo and ex vivo approaches. Male rats received a Lieber–DeCarli liquid diet, of which 36% of the calories were from alcohol, for …

Il-7rα On Cd4+ T Cells Is Required For Their Survival And The Pathogenesis Of Experimental Autoimmune Encephalomyelitis, Gholamreza Azizi, Bram Van Den Broek, Larissa Ishikawa, Hamed Naziri, Reza Yazdani, Guang-Xian Zhang, Bogoljub Ciric, Mohamad Rostami

Department of Neurology Faculty Papers

BACKGROUND: The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4+ T cells and their differentiation to effector/memory CD4+ T cells. Mice lacking IL-7Rα have severe lymphopenia and are resistant to experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. However, it has been reported that IL-7Rα on peripheral CD4+ T cells is disposable for their maintenance and EAE pathogenesis, which does not align with the body of knowledge on the role of IL-7Rα in the biology of CD4+ T cells. Given that a definitive study …

Impact Of Cancer Therapy On Clonal Hematopoiesis Mutations And Subsequent Clinical Outcomes, Kevin T Nead, Taebeom Kim, Lijin Joo, Tina L Mcdowell, Justin W Wong, Irenaeus C C Chan, Elizabeth Brock, Jing Zhao, Ting Xu, Chad Tang, Chang-Lung Lee, Jun-Ichi Abe, Kelly L Bolton, Zhongxing Liao, Paul A Scheet, Steven H Lin

Faculty, Staff and Student Publications

Exposure to cancer therapies is associated with an increased risk of clonal hematopoiesis (CH). The objective of our study was to investigate the genesis and evolution of CH after cancer therapy. In this prospective study, we undertook error-corrected duplex DNA sequencing in blood samples collected before and at 2 time points after chemoradiation in patients with esophageal or lung cancer recruited from 2013 to 2018. We applied a customized workflow to identify the earliest changes in CH mutation count and clone size and determine their association with clinical outcomes. Our study included 29 patients (87 samples). Their median age was …

Program Review Report 10-8-24, Angela Brock

Program Review Committee

No abstract provided.

Bricks Transfer And Completed Aa/As Degrees, Angela Brock

General Education Committee

No abstract provided.

Poverty And Neglect In Child Welfare Law, Laken Albrink, Cameron M. Stamper

Justice Festival at Morehead State University

A PowerPoint presentation, titled "Poverty and Neglect in Child Welfare Law," given by Laken Albrink and Cameron M. Stamper at the Justice Festival held on the campus of Morehead State University on October 8, 2024.