Digital Commons Network^™

Fabrication Of Implant Supported Hybrid Denture Using Multi-Unit Abutments In A Patient With Generalised Aggressive Periodontitis, Anupama Aradya, Raghavendra Swamy K N, Chandan S N, Prashanth M B

International Journal of Health and Allied Sciences

This case report describes the prosthodontic rehabilitation of a geriatric patient with generalized aggressive periodontitis. The patient was advised to for full extraction. An implant supported hybrid prosthesis with multi-unit abutments was fabricated for the patient who chose a fixed kind of prosthesis. Implants were placed in the maxillary & mandibular arch. Frameworks were waxed, plastic castable abutments were used for casting, denture teeth were waxed to the hybrid framework and a final wax try-in to check and adjust the maxilla-mandibular relationships before processing, the prosthesis was placed. The clinical and radiologic results met expectations.

Scales Of Whiteness And Racial Mixing: Challenging And Confirming Racial Categories, Serin D. Houston

The Geographical Bulletin

This paper examines personal and public portrayals of the self and family articulated by heterosexual mixed-race households living in the Pacific Northwest of the United States. It argues that an attention to scale sheds light on how mixed-race partnerships and households both reproduce a racial hierarchy and express shifting racial identities. A focus on the work of whiteness – defined here as an evaluative set of practices and processes that implicitly or explicitly legitimate a static racial hierarchy – in the confirmation of and challenges to racial categories further specifies my claims. I explore seemingly contradictory expressions of race in …

[Discussions] Vol. 17 Iss. 2

Discussions

No abstract provided.

Ligand Directed Signalling In Therapeutics, Julia Shield

Discussions

No abstract provided.

How Emotions In Hearing Testimonies Shape Mental Health Policy-Making: An Application Of The Social Construction Theory Of Emotion To The Legislative Process, Aarthi Uthayakumar

Discussions

No abstract provided.

Disemboweling Binaries: How Medical Texts And Gothic Fiction Propagate Deviance Through The Damaged Brain, Hailey Q. Barab

Discussions

No abstract provided.

Spectrum, Volume 53, Issue 5, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Vice Presidential Candidates Debate Ahead of Nov. Election - SHU-Powered Poll Reveals Youth Climate Concerns - A Peek Into Family Weekend Campus - The Statues of Sacred Heart University - New Hub to Stream SHU Sports

October 9, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Sustainable Aquaculture And Youth Membership, Stephen Hughes

Sustainability Research & Practice Seminar Presentations

Dr. Steven Hughes of Cheyney University discusses Sustainable Aquaculture and Youth Mentorship

Philharmonic Orchestra & Chamber Ensembles

Bailey School of Music Concert Programs

Nancy Conley, Conductor

Employing Multi-Omics Analyses To Understand Changes During Kidney Development In Perinatal Interleukin-6 Animal Model., Ganesh Panzade, Tarak Srivastava, Daniel P. Heruth, Mohammad Rezaiekhaligh, Jianping Zhou, Zhen Lyu, Mukut Sharma, Trupti Joshi

Manuscripts, Articles, Book Chapters and Other Papers

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality globally. Maternal obesity during pregnancy is linked to systemic inflammation and elevated levels of the pro-inflammatory cytokine interleukin-6 (IL-6). In our previous work, we demonstrated that increased maternal IL-6 during gestation impacts intrauterine development in mice. We hypothesized that IL-6-induced inflammation alters gene expression in the developing fetus. To test this, pregnant mice were administered IL-6 or saline during mid-gestation. Newborn mouse kidneys were analyzed using mRNA-seq, miRNA-seq and whole-genome bisulfite-seq (WGBS). A multi-omics approach was employed to quantify mRNA gene expression, miRNA expression and DNA methylation, using …

Experimental Investigation Of Vertical Axis Wind Turbine Performance Using Bio-Inspired Blades, Ahmed Elbaz

Mechanical Engineering

Vertical Axis Wind Turbines (VAWT) are becoming a key player in small wind power applications. Recent research on turbine performance focused on methods to augment turbine performance to secure a more efficient and reliable wind energy conversion system to electrical power. Most of these research works rely on Computational Fluid Dynamics (CFD) simulations given the excessive cost of wind tunnel testing. Many research papers investigated innovative blade shapes in order to improve turbine performance. In the present paper, a new bioinspired, blade shape is proposed to enhance the power output of VAWT. This shape is based on modifying NACA 0018 …

Farm Waste Can Filter Microplastics In Runoff, Prevent Pollution, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Using treated plant waste as a filter reduced the presence of harmful microplastics in agricultural runoff by more than 92%, according to a new study authored by a University of Mississippi research team.

Molecular And Clinical Features Of Pancreatic Acinar Cell Carcinoma: A Single-Institution Case Series, Ashwathy Balachandran Pillai, Mahmoud Yousef, Abdelrahman Yousef, Kristin D Alfaro-Munoz, Brandon G Smaglo, Jason Willis, Robert A Wolff, Shubham Pant, Mark W Hurd, Anirban Maitra, Huamin Wang, Matthew Harold G Katz, Laura R Prakash, Ching-Wei D Tzeng, Rebecca Snyder, Luca F Castelnovo, Anthony Chen, Andrey Kravets, Kseniia Kudriavtseva, Artem Tarasov, Kirill Kryukov, Haoqiang Ying, John Paul Shen, Dan Zhao

Faculty, Staff and Student Publications

Objectives: Acinar cell carcinoma (ACC) accounts for about 1% of pancreatic cancers. The molecular and clinical features of ACC are less characterized than those of pancreatic ductal adenocarcinoma. Methods: We retrospectively evaluated the clinical and molecular features of ACC patients who underwent germline and/or somatic molecular testing at The University of Texas MD Anderson Cancer Center from 2008 to 2022 and two cases from 2023-2024 who underwent RNA and TME analysis by Boston Gene. Patient information was extracted from our institutional database with the approval of the Institutional Review Board. Results: We identified 16 patients with available molecular testing …

The South China Sea Arbitration After Eight Years: Its Implications For Jurisprudence And Third Parties, Yoshifumi Tanaka

International Law Studies

Even though eight years have passed since the issuance of the South China Sea arbitral award between the Republic of the Philippines and the People’s Republic of China, China has repeatedly claimed that the South China Sea arbitral award is null and void. Thus a question arises with regard to the legal consequences of the award in international law and international relations. The aim of this article is to consider this question by analyzing the impacts of the South China Sea arbitral award from three viewpoints: The impacts on the jurisdiction of an adjudicative body with regard to mixed disputes …

Personalized Brachytherapy: Applications And Future Directions, Piyush Pathak, Justin J Thomas, Arjit Baghwala, Chengfeng Li, Bin S Teh, Edward B Butler, Andrew M Farach

Faculty, Staff and Students Publications

Brachytherapy offers a highly conformal and adaptive approach to radiation therapy for various oncologic conditions. This review explores the rationale, applications, technological advances, and future directions of personalized brachytherapy. Integration of advanced imaging techniques, 3D-printed applicators, and artificial intelligence are rapidly enhancing brachytherapy delivery and efficiency, while genomic tests and molecular biomarkers are refining patient and dose selection. Emerging research on combining brachytherapy with immunotherapy offers unique synergistic potential, and technologies such as intensity-modulated and shielded brachytherapy applicators present novel opportunities to further optimize dose distributions. Despite these promising advances, the field faces challenges including a need to train more …

Characterizing The Influence Of Metabolism On Steady State Water Exchange In Yeast As A Potential Mri Diagnostic Biomarker, Samantha Mumford

Dissertations and Theses

Under conditions of ionic equilibrium with the environment a cell maintains a constant volume yet rapidly exchanges water molecules with the extracellular space. The rate constant for steady state water efflux, k_io, can be measured using contrast enhanced magnetic resonance (CE-MR). The active water cycling (AWC) hypothesis is puts forward that k_io is primarily influenced by cellular ATP levels and H⁺ ATPase activity at the cell membrane. Due to the correlation between k_io and ATP levels, k_io is thought to be a probable MRI biomarker for metabolic diseases such as cancer. Yet, the molecular …

Prevalence And Prognostication Of Cd5+ Mature T-Cell Lymphomas, Omar Elghawy, Miao Cao, Jason Xu, Daniel J. Landsburg, Jakub Svoboda, Sunita D. Nasta, Elise A. Chong, Stephen J. Schuster, Colin J. Thomas, Jordan S. Carter, Montreh Tavakkoli, Marco Ruella, Stefan K. Barta

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Background: T-cell lymphomas (TCLs) are a group of heterogenous cancers with poor rates and duration of response. There remains a great challenge in risk stratification of these cancers. Cluster of differentiation (CD) 5 has shown prognostic implication in many subtypes of B-cell lymphoma; however, its role in TCLs is not known. Methods: We performed a single-institution retrospective analysis of newly diagnosed patients with TCL. CD5 positivity was determined based on positive results via immunohistochemistry and/or flow cytometry. We used univariate and multivariable analysis of biological factors to assess their association with survival outcomes. Results: A total of 194 patients with …

Effects Of Supplementing Rumen-Protected Methionine And Lysine On Milk Yield And Milk Composition In Dairy Cows, Imene Kerbache, Samir Souames, Amel Haddoum, Nedjoua Lakhdara, Nassim Moula

Turkish Journal of Veterinary & Animal Sciences

The use of “health-food additives” has gained significant attention within the dairy sector, with a focus on enhancing the nutritional intake of dairy cows to improve their productivity and reproductive performance. This study aims at examining the impact of rumen-protected methionine (Met) and lysine (Lys) supplementation on production and reproductive parameters in a sample of 100 dairy cows, comprising 32 primiparous and 68 multiparous cows with an average of 5.24±2.31 years. The cows’ average milk production was determined to be 24.9±7.40 kg/day. The cows were divided into two groups, one receiving Met/Lys supplementation and the other serving as a control …

Phase I/Ii Study Of Bms-986156 With Ipilimumab Or Nivolumab With Or Without Stereotactic Ablative Radiotherapy In Patients With Advanced Solid Malignancies, Joe Y Chang, Xinyan Xu, Girish S Shroff, Nathan I Comeaux, Wei Li, Jordi Rodon Ahnert, Daniel D Karp, Ecaterina E Dumbrava, Vivek Verma, Aileen Chen, James Welsh, David S Hong

Faculty, Staff and Student Publications

Background: BMS-986156 is an agonist of the glucocorticoid-induced tumor necrosis factor receptor (TNFR)-related protein (GITR) and promotes increased effector T-cell activation. Combined anti-GITR, anti-programmed death-1, anti-cytotoxic T-lymphocyte-associated protein 4 antibodies and radiotherapy improve tumor control in preclinical studies. Herein we describe the results of the safety and efficacy of BMS-986156+ipilimumab or nivolumab with/without stereotactic ablative radiotherapy (SABR) in patients with advanced solid cancers (NCT04021043).

Methods: This open-label, multigroup, single-center phase I/II study enrolled patients with histologically-confirmed stage IV solid cancers resistant to standard treatments. Group 1 (G1, n=20) received four cycles of ipilimumab (3 mg/kg) plus BMS-986156 (30 …

Monitoring Cow Behavior Based On Lying, Standing, Eating, And Ruminating Recognition Using Yolov8, Ali Saifudin, Sri Pantja Madyawati, Imam Yuadi, Rimayanti Rimayanti, Imam Mustofa, Riries Rulaningtyas, Teddy Surya Gunawan, Adnan Rahmat Anom Besari

Turkish Journal of Veterinary & Animal Sciences

Cow behavior is a crucial indicator for monitoring health, reproductive status, and welfare in livestock management. However, methods that rely on wearable devices often face significant challenges, including high costs, maintenance difficulties, and potential impacts on animal welfare. To address these limitations, this study explored the potential of using YOLOv8, a cutting-edge computer vision model, for non-invasive monitoring of cow behavior. The research methodology involved four key steps: data collection, preliminary data processing, model training, and validation. The findings revealed that YOLOv8 is capable of accurately detecting and localizing key cow behaviors—lying, standing, eating, and ruminating—achieving a mean average precision …

Investigation Of The Acaricidal Efficacy, Tolerance And Residue Levels Of Thymol-Containing Gelatin-Based Hydrogel Developed For Varroosis Control, Onur Demi̇r, Ali̇ Bi̇lgi̇li̇, Mehli̇ka Pulat

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate the acaricidal efficacy, tolerability of the target species and residue levels of a thymol-containing gelatin-based hydrogel developed as a controlled release system for varroosis control. The study was carried out on naturally infested honey bee colonies and compared with those of the negative control and positive control groups. The acaricidal efficacy (%) of the negative control, positive control and hydrogel was 21.93 ± 2.87, 81.09 ± 2.30 and 70.32 ± 2.05, respectively. For the tolerability controls, the average number of dead bees per colony was determined to be 60.80 ± 8.01, 297.40 …

An Innovative Approach: Introducing Novel Sheep Paternity Testing Panels, Onur Yilmaz, İbrahi̇m Cemal, Nezi̇h Ata, Orhan Karaca

Turkish Journal of Veterinary & Animal Sciences

The aim of this research was to create various microsatellite paternity test panels that are efficient, cost-effective, simple, and accessible for paternity assessments within the Eşme sheep breed in Western Anatolia. The study included 2432 animals from sixteen farms, consisting of 147 rams and 2285 lambs. 17 microsatellite markers were utilized in the study to develop these test panels, prioritizing markers with high polymorphic information content (PIC) and probability of exclusion (PE) values. By combining markers with varying PIC and PE values, 16 distinct paternity test panels were established. The study revealed mean values for various parameters of the microsatellites …

Assessment Of Genetic Diversity By Phenological Traits, Field Performance, And Start Codon Targeted (Scot) Polymorphism Marker Of Seventeen Soybean Genotypes (Glycine Max L.), Mahmoud Abdel-Sattar, Ehab M. Zayed, Mohamed K. Abou-Shlell, Hail Z. Rihan, Ahmed A. Helal, Nabil E.G. Mekhaile, Ghada E. El-Badan

School of Biological and Marine Sciences

The Egyptian-farmed soybeans have a wide range of genetic diversity which is most important in plant improvement programs in order to develop new higher yielding soybean genotypes. The present study is designed to determine the genetic variability among seventeen genotypes of cultivated soybean (Glycine max L.) by examining the phenotypic level at the seedling stage, field performance over two years 2022/2023 and genetically using Start Codon Targeted (SCoT) markers. Results indicated that the SCoT markers, 100 seed weight, and tip angle (TA) traits were positively correlated with H2L12, DR 101, H15L5, and H117 genotypes. In addition, the number of branches …

Sexual Dimorphism And Divergent Evolutionary Pathways In Primate Cranial Biomechanics: Insights From A Theoretical Morphology Framework, Z. Jack Tseng, Claire E. Terhune

Anthropology Faculty Publications and Presentations

he mammalian order Primates is known for widespread sexual dimorphism in size and phenotype. Despite repeated speculation that primate sexual size dimorphism either facilitates or is in part driven by functional differences in how males and females interact with their environments, few studies have directly assessed the influence of sexual dimorphism on performance traits. Here, we use a theoretical morphology framework to show that sexual dimorphism in primate crania is associated with divergent biomechanical performance traits. The degree of dimorphism is a significant covariate in biomechanical trait divergence between sexes. Males exhibit less efficient but stiffer cranial shapes and significant …

Rare Variant Contribution To The Heritability Of Coronary Artery Disease, Ghislain Rocheleau, Shoa L Clarke, Gaëlle Auguste, Natalie R Hasbani, Alanna C Morrison, Adam S Heath, Lawrence F Bielak, Kruthika R Iyer, Erica P Young, Nathan O Stitziel, Goo Jun, Cecelia Laurie, Jai G Broome, Alyna T Khan, Donna K Arnett, Lewis C Becker, Joshua C Bis, Eric Boerwinkle, Donald W Bowden, April P Carson, Patrick T Ellinor, Myriam Fornage, Nora Franceschini, Barry I Freedman, Nancy L Heard-Costa, Lifang Hou, Yii-Der Ida Chen, Eimear E Kenny, Charles Kooperberg, Brian G Kral, Ruth J F Loos, Sharon M Lutz, Joann E Manson, Lisa W Martin, Braxton D Mitchell, Rami Nassir, Nicholette D Palmer, Wendy S Post, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Elizabeth A Regan, Stephen S Rich, Jennifer A Smith, Kent D Taylor, Lisa R Yanek, Kendra A Young, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Austin T Hilliard, Catherine Tcheandjieu, Patricia A Peyser, Ramachandran S Vasan, Jerome I Rotter, Clint L Miller, Themistocles L Assimes, Paul S De Vries, Ron Do

Faculty, Staff and Student Publications

Whole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary artery disease (CAD). To measure their contribution, we apply the GREML-LDMS-I approach to WGS of 4949 cases and 17,494 controls of European ancestry from the NHLBI TOPMed program. We estimate CAD heritability at 34.3% assuming a prevalence of 8.2%. Ultra-rare (minor allele frequency ≤ 0.1%) variants with low linkage disequilibrium (LD) score contribute ~50% of the heritability. We also investigate CAD heritability enrichment using a diverse set of functional annotations: i) constraint; ii) predicted protein-altering impact; iii) cis-regulatory elements from a cell-specific chromatin …

Winonan, Winona State University

The Winonan - 2020s

This issue of the Winonan, the Winona State University student newspaper, was published on October 9, 2024.

Single-Cell Somatic Copy Number Variants In Brain Using Different Amplification Methods And Reference Genomes, Ester Kalef-Ezra, Zeliha Gozde Turan, Diego Perez-Rodriguez, Ida Bomann, Sairam Behera, Caoimhe Morley, Sonja W Scholz, Zane Jaunmuktane, Jonas Demeulemeester, Fritz J Sedlazeck, Christos Proukakis

Faculty, Staff and Students Publications

The presence of somatic mutations, including copy number variants (CNVs), in the brain is well recognized. Comprehensive study requires single-cell whole genome amplification, with several methods available, prior to sequencing. Here we compare PicoPLEX with two recent adaptations of multiple displacement amplification (MDA): primary template-directed amplification (PTA) and droplet MDA, across 93 human brain cortical nuclei. We demonstrate different properties for each, with PTA providing the broadest amplification, PicoPLEX the most even, and distinct chimeric profiles. Furthermore, we perform CNV calling on two brains with multiple system atrophy and one control brain using different reference genomes. We find that 20.6% …

Protocol For Evaluating Anion Exchange Membranes For Nonaqueous Redox Flow Batteries, Jessica L. Tami, Md Motiur R. Mazumder, Grace E. Cook, Shelley D. Minteer, Anne J. Mcneil

Chemistry Faculty Research & Creative Works

Nonaqueous redox flow batteries often suffer from reduced battery lifetime and decreased coulombic efficiency due to crossover of the redox-active species through the membrane. One method to mitigate this undesired crossover is to judiciously choose a membrane based on several criteria: swelling and structural integrity, size and charge of redox active species, and ionic conductivity. Most research to date has focused on reducing crossover by synthesizing modified redox-active molecules and/or new membranes. However, no standard protocol exists to compare membranes and a comprehensive study comparing membranes has yet to be done. To address both these limitations, we evaluate herein 26 …

Honey Targets Ribosome Biogenesis Components To Suppress The Growth Of Human Pancreatic Cancer Cells, Aun A. Bangash, Sahir S. Alvi, Muhammad Bangash, Haider Ahsan, Shiza Khan, Rida Shareef, Georgina Villanueva, Divyam Bansal, Mudassier Ahmad, Dae Joon Kim, Subhash Chauhan, Bilal B. Hafeez

School of Medicine Publications

Simple Summary

Pancreatic cancer (PanCa) is one of the deadliest forms of cancer with limited therapeutic options. The available conventional therapies are highly toxic and often show resistance. Accumulating evidence suggests that dysregulated ribosome biogenesis has been linked to the survival and aggressive phenotypes of many tumor types, including PanCa. Thus, targeting ribosome biogenesis could be a novel approach for suppressing the growth of PanCa. The current study aimed to investigate the anti-cancer efficacy and underlying molecular mechanisms of honey against PanCa. Our results demonstrated that honey induces apoptosis and inhibits the growth and invasive potential of PanCa cells by …