Digital Commons Network^™

Disentangling Socioeconomic Status And Race In Infant Brain, Birth Weight, And Gestational Age At Birth: A Neural Network Analysis, Kathryn Sarullo, Deanna M Barch, Christopher D Smyser, Cynthia Rogers, Barbara B Warner, J Philip Miller, Sarah K England, Joan Luby, S Joshua Swamidass

2020-Current year OA Pubs

BACKGROUND: Race is commonly used as a proxy for multiple features including socioeconomic status. It is critical to dissociate these factors, to identify mechanisms that affect infant outcomes, such as birth weight, gestational age, and brain development, and to direct appropriate interventions and shape public policy.

METHODS: Demographic, socioeconomic, and clinical variables were used to model infant outcomes. There were 351 participants included in the analysis for birth weight and gestational age. For the analysis using brain volumes, 280 participants were included after removing participants with missing magnetic resonance imaging scans and those matching our exclusion criteria. We modeled these …

An Internet Mantram Repetition Program To Promote Well-Being In Breast Cancer Survivors: A Feasibility Randomized Controlled Trial, Jennifer M Hulett, An-Lin Cheng, Jill E Bormann, Allison B Anbari, Jane M Armer, Brooke M Hartman, B Ann Bettencourt, Leeanne B Sherwin, Edie L Sperling, Natsayakarn Narkthong, Carol Reinero, Hans Rindt, Kathy Schreiber, Lindsay L Peterson, Emily Albright

2020-Current year OA Pubs

No abstract provided.

Age-Related Alterations In Gray Matter Microstructure In Older People With Remitted Major Depression At Risk For Dementia, John A E Anderson, Neda Rashidi-Ranjbar, Arash Nazeri, Jordan A Chad, Peter Zhukovsky, Benoit H Mulsant, Nathan Herrmann, Linda Mah, Alastair J Flint, Corinne E Fischer, Bruce G Pollock, Tarek K Rajji, Aristotle N Voineskos, Pact-Md Study Group

2020-Current year OA Pubs

BACKGROUND: Major depressive disorder (MDD) in late life is a risk factor for mild cognitive impairment (MCI) and Alzheimer's disease. However, studies of gray matter changes have produced varied estimates of which structures are implicated in MDD and dementia. Changes in gray matter volume and cortical thickness are macrostructural measures for the microstructural processes of free water accumulation and dendritic spine loss.

METHODS: We conducted multishell diffusion imaging to assess gray matter microstructure in 244 older adults with remitted MDD (

RESULTS: Results showed that increasing age was correlated with an increase in isotropic volume fraction and a decrease in …

Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification By The Enigma Ptsd Consortium, Benjamin Suarez-Jimenez, Evan M Gordon, Et Al.

2020-Current year OA Pubs

BACKGROUND: Intrusive traumatic re-experiencing domain (ITRED) was recently introduced as a novel perspective on posttraumatic psychopathology, proposing to focus research of posttraumatic stress disorder (PTSD) on the unique symptoms of intrusive and involuntary re-experiencing of the trauma, namely, intrusive memories, nightmares, and flashbacks. The aim of the present study was to explore ITRED from a neural network connectivity perspective.

METHODS: Data were collected from 9 sites taking part in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) PTSD Consortium (

RESULTS: rsFC signatures differentiated TE-only participants from PTSD and ITRED-only participants at about 60% accuracy. Conversely, rsFC signatures did …

Biology Of Childhood Hepatoblastoma And The Search For Novel Treatments, Marjut Pihlajoki, Katja Eloranta, Ruth Nousiainen, Ville Väyrynen, Tea Soini, Antti Kyrönlahti, Seppo Parkkila, Jukka Kanerva, David B. Wilson, Mikko P. Pakarinen, Markku Heikinheimo

2020-Current year OA Pubs

No abstract provided.

Bioactive Glycans In A Microbiome-Directed Food For Children With Malnutrition, Matthew C Hibberd, Daniel M Webber, Suzanne Henrissat, Robert Y Chen, Cyrus Zhou, Hannah M Lynn, Yi Wang, Hao-Wei Chang, Evan M Lee, Janaki Lelwala-Guruge, Ye Chen, Ishita Mostafa, Subhasish Das, Mustafa Mahfuz, Michael J Barratt, Tahmeed Ahmed, Jeffrey I Gordon, Et Al.

2020-Current year OA Pubs

Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition

The Cousa Objective: A Long-Working Distance Air Objective For Multiphoton Imaging In Vivo, Che-Hang Yu, Jinkyung Kim, Et Al.

2020-Current year OA Pubs

Multiphoton microscopy can resolve fluorescent structures and dynamics deep in scattering tissue and has transformed neural imaging, but applying this technique in vivo can be limited by the mechanical and optical constraints of conventional objectives. Short working distance objectives can collide with compact surgical windows or other instrumentation and preclude imaging. Here we present an ultra-long working distance (20 mm) air objective called the Cousa objective. It is optimized for performance across multiphoton imaging wavelengths, offers a more than 4 mm

A Global Multicohort Study To Map Subcortical Brain Development And Cognition In Infancy And Early Childhood, Ann M Alex, Kelly Botteron, Et Al.

2020-Current year OA Pubs

The human brain grows quickly during infancy and early childhood, but factors influencing brain maturation in this period remain poorly understood. To address this gap, we harmonized data from eight diverse cohorts, creating one of the largest pediatric neuroimaging datasets to date focused on birth to 6 years of age. We mapped the developmental trajectory of intracranial and subcortical volumes in ∼2,000 children and studied how sociodemographic factors and adverse birth outcomes influence brain structure and cognition. The amygdala was the first subcortical volume to mature, whereas the thalamus exhibited protracted development. Males had larger brain volumes than females, and …

Elevating Voices, Addressing Depression, Toxic Stress, And Equity Through Group Prenatal Care: A Pilot Study, Shannon N Lenze, Kelly Mckay-Gist, Rachel Paul, Melissa Tepe, Katherine Mathews, Sara Kornfield, Cheron Phillips, Richelle Smith, Amanda Stoermer, Ebony B Carter

2020-Current year OA Pubs

INTRODUCTION: Elevating Voices, Addressing Depression, Toxic Stress and Equity (EleVATE) is a group prenatal care (GC) model designed to improve pregnancy outcomes and promote health equity for Black birthing people. This article outlines the foundational community-engaged process to develop EleVATE GC and pilot study results.

METHODS: We used community-based participatory research principles and the Ferguson Commission Report to guide creation of EleVATE GC. The intervention, designed by and for Black birthing people, centers trauma-informed care, antiracism, and integrates behavioral health strategies into group prenatal care to address unmet mental health needs. Using a convenience sample of patients seeking care at …

Neurosteroids: Mechanistic Considerations And Clinical Prospects, Jamie L Maguire, Steven Mennerick

2020-Current year OA Pubs

Like other classes of treatments described in this issue's section, neuroactive steroids have been studied for decades but have risen as a new class of rapid-acting, durable antidepressants with a distinct mechanism of action from previous antidepressant treatments and from other compounds covered in this issue. Neuroactive steroids are natural derivatives of progesterone but are proving effective as exogenous treatments. The best understood mechanism is that of positive allosteric modulation of GABA

Sirtuin3 Ensures The Metabolic Plasticity Of Neurotransmission During Glucose Deprivation, Anupama Tiwari, Arsalan Hashemiaghdam, Marissa A Laramie, Dario Maschi, Tristaan Haddad, Marion I Stunault, Carmen Bergom, Ali Javaheri, Vitaly Klyachko, Ghazaleh Ashrafi

2020-Current year OA Pubs

Neurotransmission is an energetically expensive process that underlies cognition. During intense electrical activity or dietary restrictions, the glucose level in the brain plummets, forcing neurons to utilize alternative fuels. However, the molecular mechanisms of neuronal metabolic plasticity remain poorly understood. Here, we demonstrate that glucose-deprived neurons activate the CREB and PGC1α transcriptional program, which induces expression of the mitochondrial deacetylase Sirtuin 3 (Sirt3) both in vitro and in vivo. We show that Sirt3 localizes to axonal mitochondria and stimulates mitochondrial oxidative capacity in hippocampal nerve terminals. Sirt3 plays an essential role in sustaining synaptic transmission in the absence of glucose …

Characterization Of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels In Oligodendrocytes., Kyle A Lyman, Ye Han, Andrew P Robinson, Samuel E Weinberg, Daniel W Fisher, Robert J Heuermann, Reagan E Lyman, Dong Kyu Kim, Andreas Ludwig, Navdeep S Chandel, Mark D Does, Stephen D Miller, Dane M Chetkovich

2020-Current year OA Pubs

Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic role for these cells in the plasticity of neural circuits, leading to a renewed interest in voltage-sensitive currents in OLG. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and their respective current (I

An Optimal Culture Medium For Laccase Production And Sugar Cane Vinasse Biotreatment With Trametes Villosa Using Plackett-Burman And Central Composite Designs, Rosa Elena Caballero, Víctor Jiménez, Mónica Miranda, Dalys Rovira, Guillermo Branda, Juana Ramos Chue De Pérez

Applied Environmental Research

The optimal conditions for laccase production and vinasse biotreatment with a native strain of Trametes villosa were determined by a screening-optimization approach. Eleven factors including nutrient concentration, vinasse dilution (%v/v), inoculum volume, carbon to nitrogen ratio and initial pH, were investigated for their effects on laccase activity applying the Plackett-Burman screening design. The selected factors were optimized using a central composite design, and then evaluated on a vinasse biotreatment experiment. The factors that contributed the most to the enzymatic activity were the concentrations of MgSO4∙7H2O (A), FeSO4∙7H2O (B) and CuSO4∙5H2O (C), alongside initial pH.  After 10 days, laccase activity was …

Photosynthesis-Related Parameters In Leucobryum Aduncum Moss Bags As Bioindicators Of Environmental Stress Caused By Road Traffic, Chaiwat Boonpeng, Pawanrat Butrid, Marisa Pischom, Sutatip Noikrad, Kansri Boonpragob

Applied Environmental Research

The physiological response in moss samples is often used as an early warning signal of environmental stress caused by air pollution. This study aimed to test the efficiency of photosynthesis-related parameters in Leucobryum aduncum moss bags as bioindicators of environmental stress related to road traffic. The moss samples were collected and prepared in a relatively unpolluted area and then transplanted at 7 sites in forested, rural, and urban areas. The moss samples were picked up after being exposed for 1 and 3 months for physiological measurements. The results showed that the average values of all physiological parameters were highest in …

Exploring Microplastics In Seawater And Zooplankton On The Eastern Coast Of Thailand: A Case Study In Phuket Province, Pensiri Akkajit, Sirima Yuankerd, Arsanchai Sukkuea

Applied Environmental Research

Microplastics can accumulate in the environment and be transferred to different trophic levels, making them a concern for the aquatic food chain. As far as the researcher is aware, this study is the first to analyze microplastics in seawater and zooplankton along the eastern coastline of Phuket, Thailand, emphasizing their ecological significance. Analysis of the seawater samples identified 256 microplastic particles, with an average concentration of 52.6±21.4 and 32.6±30.3 particles L-1 for 20–300 µm and >300 µm classes, respectively. Four zooplankton species—copepod, fish larvae, bivalvia larvae, and shrimp larvae—were chosen for examination. The findings indicated that microplastics can move to …

Luminescence Inhibition Of Water-Soluble Fractions Of Crude Oil, Diesel And Spent Engine Oil On Freshly Isolated Vibrio Campbellii, Beatrice Omolola Bello, Olayide Samuel Lawal, Gbenga Emmanuel Olumayede, Ogochukwu Angela Agwu, Stanley Ozoemena Agbo

Applied Environmental Research

Inhibitory effects of water-soluble fraction (WSF) of crude oil, diesel, spent engine oil, and their composite mixture on luminescent Vibrio species isolated from a tropical marine fish were assessed to determine the acute toxicity and suitability of the bacteria. This was evaluated with a slight modification of the procedure for freshly prepared luminescent marine bacteria according to the International Organization for Standardization. Toxicity was assessed following bacterial exposure to different concentrations of the WSFs. Water quality parameters and total polycyclic aromatic hydrocarbons (PAHs) were determined using standard methods. Chemical analysis revealed cumulative loads of PAHs in the WSFs of crude …

Meteorological Conditions And Pm2.5 Impact On Covid-19 Case Fatality Ratios (Cfr) In Bangkok Metropolitan Region, Viranphat Singrakphon, Chidsanuphong Chart-Asa, Pasicha Chaikaew

Applied Environmental Research

The emergence of a novel coronavirus strain triggered a global health crisis, impacting both health and economies worldwide, including Thailand since 2019. While prior research hinted at connections between environmental factors and rising COVID-19 cases, these links remained inconclusive. This study investigated indoor and outdoor (I/O) ratios and explored potential correlations between fine particulate matter (PM2.5), meteorological conditions, and the case fatality rate (CFR%) of COVID-19 in Bangkok and its metropolitan area from January to December 2021. In Spearman’s Rank correlation analysis, the results found that CFR% exhibited a positive correlation with relative humidity (RH) (r=0.187) and a negative correlation …

Use Of Modified Blast Furnace Slag For Cadmium Removal In An Aqueous Medium, Toufik Chouchane, Mohamed Tayeb Abedghars, Sabiha Chouchane, Hazem Meradi, Atmane Boukari

Applied Environmental Research

In this work, blast furnace slag was converted to hydroxyapatite-zeolite (MS) through alkaline fusion and hydrothermal treatment, and then it was used to remove cadmium in solution by adsorption in batch mode. The process was accomplished under the influence of determining parameters, namely the contact time, mass of the adsorbent, stirring speed, pH of the medium, temperature of the solution, particle size of the slag, and initial concentration. MS consists mainly of sodium oxide, silica, alumina, lime, and phosphorus pentoxide. The Ca/P, Na/Al, and Si/Al ratios revealed that the converted slag is a hydroxyapatite-zeolite. Following the modification of the treated …

Simulated Microgravity, Indole-3-Acetyl Acid, And Cow Dung Influence On Zea Mays Plant Growth In Contaminated Soil, A. Ovenseri, A.O. Ogunkeyede, A.A. Adebayo, P. Tawari-Fufeyin, A.O. Orukpe, C. Udeochu Uche

Applied Environmental Research

This study investigated the effects of simulated microgravity, indole-3-acetic acid (IAA), and cow dung on Zea mays L. plants growing in soil contaminated with crude oil. Crude oil contamination affects plants negatively in morphology and physiology. For simulated microgravity exposure, IAA introduced and non-IAA introduced seeds of Zea mays L. were grown in a clinostat for 4days before taken to the nursery for planting. IAA was introduced to the seed by soaking in IAA solution for 90 minutes after which it was introduced to the microgravity stimulator (clinostat). After 14 days in the nursery, the seedlings were taken to the …

Alstonia Scholaris Fruit Biomass, A Novel Adsorbent For The Removal Of Lead From Aqueous Solution, Aasif Abdullah Baba, Ajit Kumar Das, Abhik Gupta

Applied Environmental Research

The biosorption of lead (Pb) ions on Alstonia scholaris fruit biomass was investigated in batch and column experiments in an aqueous solution, emphasising the possible binding mechanism of Pb ions on the fruit biomass. The adsorption process was found to be dependent on parameters like adsorbent dose, initial Pb ion concentration, contact time, and pH. No impact was found on Pb adsorption during competitive adsorption. The results suggested that the fruit biomass could remove more than 97% of Pb ions from the aqueous solution. The Freundlich isotherm model best explained the obtained results. The monolayer adsorption capacity of the A. …

A Review On Water Security In Dhaka City, Bangladesh: Calling For Ensuring Sustainability, Wasim Akram, Wilailuk Niyommaneerat, Athit Phetrak, Suthirat Kittipongvises

Applied Environmental Research

Dhaka is currently facing a number of significant challenges, and one of them is the protection of water resources. The city is experiencing rapid depletion of groundwater as well as substantial pollution of its surface water. This article aims to highlight a review of the literature on the challenges of water security in Dhaka. The sustainability issues of water resources were elaborated in terms of management, quantity, and quality aspects. Having reviewed, it has been found that groundwater is depleting drastically over the years, which may have environmental, economic, and social consequences in the near future. Due to the rapid …

Effect Of Operating Parameters On Photocatalytic Treatment Of Synthetic Wastewater Using Catio3, Shilpa Mishra, Rekha Dom, Baranidharan Sundaram

Applied Environmental Research

Photocatalysis is thought to be a long-term, environmentally friendly, economically feasible, and promising technique for treating wastewater. The development of semiconductor nanoparticles has generated a great deal of interest in the treatment of wastewater. To break down complex contaminants found in wastewater into simpler compounds, including H2O and CO2, several UV/visible light excitable nanomaterials have been explored as photocatalysts. Their effectiveness can be managed by adjusting several reaction-related parameters like the intensity of light, irradiance time, pH, catalyst dose, temperature, doping, etc. The performance of the photocatalyst in the photodegradation of contaminants is greatly affected by these parameters. The main …

Assessing The Relationship And Effect Of Air Pollution [Pm 2.5] On Child Respiratory Illness And Child Mortality In The Philippines, Roel F. Ceballos, Rachell C. Gallano, Lenard D. Visaya

Applied Environmental Research

Air pollution is the presence of harmful substances in the air, which can seriously impact human health and the environment. Among the air pollutants, fine particulate matter (PM) 2.5, being a microscopic particle, poses serious health risks since it can enter the blood circulation and go deep into the lungs. PM 2.5 has been linked to several health problems, such as early mortality, problems with children's development, and unfavorable birth outcomes. In this regard, the study aims to investigate the relationship and effect of PM 2.5 on child respi-ratory illness and child mortality in the Philippines. Data on child respiratory …

Assessing The Short- And Long-Term Health Effects Of Nitrogen Dioxide In Agadir, Morocco: A Who Airq+ Model Application, Youssef Bouchriti, Mohamed Ait Haddou, Abderrahmane Achbani, Amal Korrida, Hasnaa Sine, Jamila Rida, Mohamed Boukrim, Belkacem Kabbachi

Applied Environmental Research

Epidemiological studies have revealed that exposure to atmospheric nitrogen dioxide (NO2) increases the risk of acute and chronic diseases. This study used the WHO AirQ model to assess both the short- and long-term impacts of NO2 on human health in the city of Agadir in Morocco. The mean NO2 values were obtained from measurements taken at two locations. This study assessed the long- term health effects of NO2 on natural all-cause mortality (LT-ACM), mortality due to respiratory diseases (LT-RD), and morbidity due to chronic obstructive pulmo-nary disease (LT-COPD), as well as the short-term health impacts of NO2 on natural all-cause …

Spatiotemporal Patterns Of Land Surface Temperature, Urban Heat Island, And Potential Heat Stress Risk Areas Assessment For Tropical Inland City And Coastal City In Thailand, Thar Htet Aung, Sakpod Tongleamnak, Rasamee Suwanwerakamtorn

Applied Environmental Research

Global warming and rapid urban growth, compounded by the urban heat island (UHI) effect, are posing substantial challenges for urban populations and ecological well-being due to increased heat stress risks. This study aimed to analyze the spatiotemporal patterns of land surface temperature (LST), UHI, and potential heat stress risk areas (PHSRA) in two distinct cities, an inland city, Nakhon Ratchasima, and a coastal city, Si Racha, during the summer. Geoinformatics techniques and Crichton’s Risk Triangle method were employed, using updated demographic data and Sentinel-3 data from 2017 to 2022. The findings indicate that the inland city daytime average LST values …

Optimizing Tenebrio Molitor Feeding Strategy To Induce Physical Degradation Of Tires: A Novel Approach For Sustainable Waste Management, Abdussalam Topandi, Khadijah Sayyidatun Nisa, Fatimah Azizah Riyadi, Ibnu Maulana Hidayatullah, Pranata -, Firah Gustianda Ayu, Reynaldi Ivan Prasetya, Frederick Soetandar, Dimas Rafi Narawangsa, Eka Rahayu

Applied Environmental Research

Due to the increased usage of tires, the accumulation of worn tires has become a significant environmental concern and necessitates environmentally friendly waste management strategies. Conventional methods, such as tire incineration or improper disposal, contribute to environmental degradation. It is reported that organisms, such as Tenebrio molitor larvae, can degrade a wide range of polymers. This study explores the promising potential of Tenebrio molitor larvae in addressing this concern. Through a series of experiments, Tenebrio molitor larvae were fed with cut-worn tires to facilitate degradation. The larvae exhibited remarkable capabilities, surviving and thriving on tires as a sole carbon source …

Screening, Isolation And Hydrocarbon Degradation Characteristics Of Yeasts From Mangrove Sediments Of Kerala, Vidya Pothayi, Sreedevi N Kutty, Sebastian Chempakassery Devasia

Applied Environmental Research

The aim of the present work was to examine the hydrocarbon degradation potential of yeasts isolated from the mangrove sediments. Mangrove sediments around the world were considered to be heavily polluted with oil contaminants and the microbes dwelling in them were believed to be highly active in metabolizing and detoxifying the oil fractions. In the present study, 70 yeast isolates were screened for their lipolytic activity qualitatively and 35 of them which showed comparatively higher lipolysis were tested for their crude oil degradation ability. Screening of hydro-carbon utilizing isolates was performed on Bushnell Haas agar media overlaid with 1% crude …