Digital Commons Network^™

Using Wavelet Transform And Hybrid Cnn – Lstm Models On Voc & Ultrasound Iot Sensor Data For Non-Visual Maize Disease Detection, Theofrida Maginga, Emmanuel Masabo, Pierre Bakunzibake, Kwang-Soo Kim, Jimmy Nsenga

All Rsif Scholars' Publications

Early detection of plant diseases is crucial for safeguarding crop yield, especially in regions vulnerable to food insecurity, such as Sub-Saharan Africa. One of the significant contributors to maize crop yield loss is the Northern Leaf Blight (NLB), which traditionally takes 14–21 days to visually manifest on maize. This study introduces a novel approach for detecting NLB as early as 4–5 days using Internet of Things (IoT) sensors, which can identify the disease before any visual symptoms appear. Utilizing Convolutional Neural Networks (CNN) and Long Short Term Memory (LSTM) models, nonvisual measurements of Total Volatile Organic Compounds (VOCs) and ultrasound …

Phase Structure Transformation And Growth Mechanism For Iron Oxide Nanoparticles Synthesized By Mechanochemical Method: A Mini-Review, Joseph Ekhebume Ogbezode, Nkechi Elizabeth Offia-Kalu, Bello A. Abdulhakeem, Vitalis Chioh Anye, Peter Azikiwe Onwalu

All Rsif Scholars' Publications

The various methods of synthesis of iron oxide nanoparticles (IONPs) have been extensively studied in several works of literature. These methods include physical, chemical, and biological nanosynthesis methods with applications in water filtration, environmental remediation, plant improvements, biomedicines, etc. These nanosynthesis approaches revolve around their mode of application, nanomaterial properties, and characterization mechanisms, while little effort has been made to investigate the effect of nanosynthesis parameters based on phase transformation and growth mechanisms of such IONPs. The parameters, which are physical, chemical, mechanical, mineralogical, and morphological, have proven to have tremendous implications on the magnetic behaviors, crystalline size, degree of …

Response Of Species To The Impact Of Climate Change In The Gum Arabic Belt, Sudan: A Case Study In Acacia Senegal, Fatima Awadalla Abass Elhassan, Edouard Konan Kouassi, Haftu Abrha, Ahmed Laamarni, Ahmed Ali Hassabelkareem Siddig

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Sustainable management strategies of trees are important for indigenous agroforestry plant species, such as Acacia. Senegal (A. Senegal), due to the impacts of rapid population growth, land use and climate change. The objective of this investigation was to predict the spatio-temporal distribution of A.senegal in the Gum Arabic belt in Sudan in current (1985–2000) and future climate scenarios (2021–2100). Bioclimatic data was used for modeling purposes utilizing Maxent, with the assessment of model precision conducted through the utilization of the Area Under the Curve (AUC) and shown a high goodness-of-it (AUC=0.905±0.003 ). Significant differences were shown in species distribution between …

Three Decades Of Research Efforts On The Uses, Conservation, And Management Of Cola Nitida (Vent.): State Of Knowledge And Prospects In Africa, Isabelle Erhudice Tachégnon Tokannou, Souleymane Sanogo, Juliano S.H Houndonougbo, Kolawolé Valère Salako, Adandé Belarmain Fandohan

All Rsif Scholars' Publications

Cola nitida is a key multipurpose fruit tree species widely distributed across African countries. Several studies have investigated different aspects of the species, but there is a lack of synthesis on the current state of available literature and prospects for sustainable conservation and management of the species. Using the PRISMA approach for systematic review over the last three decades (1990–2022) in Africa, this study gathered key existing research findings on C. nitida. A total of 280 scientific publications were finally retained for this review. Several studies were focused on the socio-economic importance of the species (n = 139 …

Choice Modelling Of Ecooking Adoption By Households In Ghana, Rejoice Ntiriwaa Ossei-Bremang, Fabian Chidubem Eze, Kwame Anane-Fenin, Francis Kemausuor

All Rsif Scholars' Publications

The use of electric cooking appliances, also referred to as eCooking devices, presents a practical and
sustainable solution for achieving universal access to clean cooking facilities by 2030. A choice modelling
analysis on the factors that influence the selection of an eCooker in Ghana has been conducted to facilitate
market expansion for organisations seeking to offer clean cooking services. The study utilised Analytical
Hierarchy Process (AHP), Fuzzy-TOPSIS, and Data Envelopment Analysis (DEA) methodologies to assess and
rank electric cookers based on crucial factors such as kWh consumption rate, cooking efficiency, affordability,
time-saving features, ergonomics, space utilisation capabilities, compatibility with cookware …

Experimental Investigation And Comparative Environmental Impact Analysis Of Conventional And Naturally Occurring Kinetic Hydrate Inhibitors In Offshore Environments Using Toxicity And Bioconcentration Tools, Okon Okon, Joseph Atubokiki Ajienka, Sunday Sunday Ikiensikimama, Onyewuchi Emmanuel Akaranta, Virtue Urunwo Wachikwu-Elechi

All Rsif Scholars' Publications

In this present study, an in vivo experiment was carried out to determine the tendencies of a naturally occurring high-phenolic compound red-onion skin extract (HPC-ROSE) and conventional N-Vinylcaprolactam (N-VCAP) kinetic hydrate inhibitors (KHIs) to bio-accumulate in offshore environment through the analysis of their uptake and depuration kinetics by a Fish-Chemical Model using Cyprinus carpio marine invertebrate. This test was performed in the laboratory in a flow through experimental set up according to the guidelines by [49] (Fish-chemical exposure test). The uptake duration was 10 days with a depuration period of twenty days. The inhibitor toxicity test was evaluated by …

Solar Photovoltaic Power Output Forecasting Using Deep Learning Models: A Case Study Of Zagtouli Pv Power Plant, Sami Florent Palm, Sianou Ezéckiel Houénafa, Zourkalaïni Boubakar, Sebastian Waita, Thomas Nyachoti Nyangonda, Ahmed Chebak

All Rsif Scholars' Publications

Forecasting solar PV power output holds significant importance in the realm of energy management, particularly due to the intermittent nature of solar irradiation. Currently, most forecasting studies employ statistical methods. However, deep learning models have the potential for better forecasting. This study utilises Long Short-Term Memory (LSTM), Gate Recurrent Unit (GRU) and hybrid LSTM-GRU deep learning techniques to analyse, train, validate, and test data from the Zagtouli Solar Photovoltaic (PV) plant located in Ouagadougou (longitude:12.30702 o and latitude:1.63548 o), Burkina Faso. The study involved three evaluation metrics: Root Mean Square Error (RMSE), Mean Absolute Error (MAE), and coefficient of determination …

Microbiological Contamination Of Lettuce (Lactuca Sativa) Reared With Tilapia In Aquaponic Systems And Use Of Bacillus Strains As Probiotics To Prevent Diseases: A Systematic Review, Angelica Adiacao Jossefa, Leonildo Dos Anjo Viagem, Brunno Da Silva Cerozi, Sebastian Wilson

All Rsif Scholars' Publications

Aquaponic systems are food production systems that combine aquaculture and hydroponic in a closed recirculation system where water provides nutrients to plants while plants purify water for fish. In this system, tilapia is the most commonly cultured fish and can be easily integrated with vegetable cultivation. However, tilapia host a diverse microbiota some of which are pathogenic and can infect humans. Previous studies have reported contamination of lettuce by pathogenic bacteria which can cause human diseases. Thus, there is an urgent need to employ effective methods to control those bacteria, and Bacillus strains have been successfully used in this context. …

Spatial Analysis Of Livestock Disease Data In Sub-Saharan Africa: A Scoping Review, Alfred Ngwira, Samuel Manda, Esron Daniel Karimuribo, Sharadhuli Iddi Kimera, Christopher Stanley

All Rsif Scholars' Publications

Background

Methods

Genomic Diversity And Geographic Distribution Of Newcastle Disease Virus Genotypes In Africa: Implications For Diagnosis, Vaccination, And Regional Collaboration, Charlie Frank Arthur N'Guessan Amoia, Jean N. Hakizimana, Augustino A. Chengula, Muhammad Munir, Gerald Misinzo, James Weger-Lucarelli

All Rsif Scholars' Publications

The emergence of new virulent genotypes and the continued genetic drift of Newcastle disease virus (NDV) implies that distinct genotypes of NDV are simultaneously evolving in different geographic locations across the globe, including throughout Africa, where NDV is an important veterinary pathogen. Expanding the genomic diversity of NDV increases the possibility of diagnostic and vaccine failures. In this review, we systematically analyzed the genetic diversity of NDV genotypes in Africa using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Information published between 1999 and 2022 were used to obtain the genetic background of different genotypes of NDV …

Seroprevalence And Risk Factors Of Brucellosis In Pastoralists And Their Livestock In Central Equatoria State, South Sudan, Emmanuel Philip Lasuba Lita, Erneo B. Ochi, Gerald Misinzo, Henriette Van Heerden, Robab Katani, Jacques Godfroid,, Coletha Mathew

All Rsif Scholars' Publications

Brucellosis poses serious public health implications and substantial economic losses in pastoral rural settings in South Sudan. In humans, brucellosis is almost always originating from animals. Current literature provides scant data regarding the seroprevalence of brucellosis in South Sudan. This cross-sectional study investigates the seroprevalence of brucellosis among the pastoral community and livestock and identifies risk factors for the disease from two Counties, Terekeka and Juba in Central Equatoria State (CES), South Sudan.

Development Of Nanobodies Against The Coat Protein Of Maize Chlorotic Mottle Virus, Faith Njeri Njeru, Olivier Zwaenepoel, Geert Haesaert, Kris De Jonghe, Jan Gettemans

All Rsif Scholars' Publications

Maize lethal necrosis (MLN) is a maize disease caused by the maize chlorotic mottle virus (MCMV), a potyvirus which causes yield losses of 30–100%. The present study aimed to isolate nanobodies against the MCMV coat protein (CP) for the diagnosis of MLN. MCMV CP expressed in Escherichia coli was used for llama immunization. VHH (i.e. variable heavy domain of heavy chain) gene fragments were prepared from blood drawn from the immunized llama and used to generate a library in E. coli TG1 cells. MCMV specific nanobodies were selected by three rounds of phage display and panning against MCMV CP. The …

Can High-Value Markets Ensure Households Food Security? Evidence From Avocado Producers In Sidama Region Of Ethiopia, Zerhun Zerhun Zerhun, Kehabtimer Kebede, Aneteneh Ashebir, Zerhun Ganewo, Abera Alemu, Andachew Samuel

All Rsif Scholars' Publications

Linking farmers to high-value markets continue to be a viable option for breaking the food insecurity. Many studies have emphasized on factors determining smallholders’ participation in high-value markets. Previous studies have methodological limitations since they neglected the associated effects on food security. Therefore, the purpose this study was to fill a knowledge gap by investigating the factors influencing smallholder avocado farmers’ participation in high-value markets and how it impacts households’ food security in the Aleta chuko district, Ethiopia. The primary data was collected from randomly selected 389 avocado producers using a semi-structured questionnaire. Descriptive statistics, inferential statistics, and propensity score …

In Vitro Studies Of The Antimicrobial Properties And Qualitative Phytochemical Analysis Of Selected Chadian Medicinal Plants, Hissein Hassan Abdel-Razakh, Gaymary George Bakari, Cheol-Ho Pan, Abubakar Shaaban Hoza

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The aim of this study was to evaluate the antimicrobial potential and perform the phytochemical screening of ethanolic (70%) leaf extracts of Bauhinia rufescens and Ocimum basilicum and root extracts of Salvadora persica, three plants used for the treatment of numerous diseases in Chad. The extraction of the plants was made in a ratio of 70% volume of ethanol against 30% volume of distilled water. The yields obtained in the extraction of the leaves of Bauhinia rufescens, Ocimum basilicum, and Salvadora persica roots were respectively 20, 17, and 8.8%. With the disc diffusion method, the results of the antimicrobial assessment …

Determinants Of The Share Of The Economy Contributed By The Forestry Industry In Ghana From 1975 To 2023, Kwabena Asomanin Anaman, Samuel Ampomah, Joseph Manzvera

All Rsif Scholars' Publications

The macroeconomic determinants of the share of the economy contributed by the forestry industry in Ghana were examined over the period from 1975 to 2023, based on the development of time-series cointegration and error correction models. The analysis indicated that the share of the forestry industry was positively influenced by the real value of the cocoa industry, the exchange rate, and the real interest rate. The relationship between the forestry industry's share and per capita real gross domestic product (GDP) was found to be curvilinear: at low levels of per capita income, the share of the forestry industry in the …

Effect Of Soybean And Seaweed-Based Diets On Growth Performance, Feed Utilization, And Gut Microbiota Of Tilapia: A Systematic Review And Meta-Analysis, Leonildo Dos Anjo Viagem, Jean Nepomuscene Hakizimana, Cyrus Rumisha, Brunno Da Silva Cerozi, Gerald Misinzo

All Rsif Scholars' Publications

Tilapia, a significant aquaculture species globally, relies heavily on feed for its production. While numerous studies have investigated the impact of soybean and seaweed-based diets on tilapia, a comprehensive understanding remains elusive. This review aimed at evaluating and synthesizing the existing literature on these diets’ effects, focusing on growth performance, feed utilization, and gut microbiota. A systematic search of databases was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a total of 57 studies were included in the qualitative analysis and 24 in the meta-analysis. The results indicated that soybean-based diets, at a 59.4% inclusion …

Enhancing Sustainable Crop Production Through Integrated Nutrient Management: A Focus On Vermicompost, Bio-Enriched Rock Phosphate, And Inorganic Fertilisers – A Systematic Review, Tamara Jose Sande, Hamis J. Tindwa, Alessandra Mayumi Tokura Alovisi, Johnson M. Semoka

All Rsif Scholars' Publications

Securing a consistent food supply remains a pressing global challenge, particularly for small-scale farmers grappling with obstacles in enhancing agricultural yields, especially in tropical soils. Integrated Nutrient Management (INM) techniques, employing organic manures like vermicompost and bioenriched rock phosphate, emerge as recommended solutions. Vermicompost is lauded for its nutrient richness and positive soil health impacts. At the same time, bio-enriched rock phosphate serves as a sustainable alternative to conventional phosphorus fertilisers, specifically tailored for tropical soil conditions. Despite individual studies assessing the effects of vermicompost, bio-enriched rock phosphate, and soluble fertilisers on plant growth, a comprehensive overview of their combined …

Insights On The Microbiology Of Ethiopian Fermented Milk Products: A Review, Tiruha Habte Karssa

All Rsif Scholars' Publications

Fermented milk products play a vital role in the diets of Ethiopians. They are produced from either spontaneous fermentation or back-slopping methods at the household level, in which lactic acid bacteria (LAB) and yeasts predominate. As a result, the processing steps are not standardized and overall safety is still of public health relevance. Therefore, quality and safety improvement, standardization of traditional manufacturing practices, and commercialization of products to a wider market are important. Hence, this systematic review aimed to provide a comprehensive overview of the microbiology of traditional Ethiopian fermented milk products, including ergo (spontaneously fermented whole milk), dhanaan (fermented …

Usp22 Overexpression Fails To Augment Tumor Formation In Mmtv-Erbb2 Mice But Loss Of Function Impacts Mmtv Promoter Activity, Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J Muller, Sharon Y R Dent, Evangelia Koutelou

Faculty, Staff and Student Publications

The Ubiquitin Specific Peptidase 22 (USP22), a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear. We reported previously that Usp22 loss in mice impacts execution of several signaling pathways driven by growth factor receptors such as erythroblastic oncogene B b2 (ERBB2). To determine whether changes in USP22 expression affects ERBB2-driven tumorigenesis, we introduced conditional overexpression or deletion alleles of Usp22 into mice bearing the Mouse mammary tumor virus-Neu-Ires-Cre (MMTV-NIC) transgene, which drives both rat ERBB2/NEU expression and Cre recombinase activity from the MMTV promoter resulting …

Protection Against Fibrosis By A Bacterial Consortium In Metabolic Dysfunction-Associated Steatohepatitis And The Role Of Amino Acid Metabolism, Suet-Ying Kwan, Kristyn A Gonzales, Mohamed A Jamal, Heather L Stevenson, Lin Tan, Philip L Lorenzi, P Andrew Futreal, Ernest T Hawk, Joseph B Mccormick, Susan P Fisher-Hoch, Robert R Jenq, Laura Beretta

Faculty, Staff and Student Publications

The gut microbiota drives progression to liver fibrosis, the main determinant of mortality in metabolic dysfunction-associated steatohepatitis (MASH). In this study, we aimed to identify bacterial species associated with protection against liver fibrosis in a high-risk population, and test their potential to protect against liver fibrosis in vivo. Based on stool shotgun metagenomic sequencing of 340 subjects from a population cohort disproportionally affected by MASH, we identified bacterial species from the Bacteroidales and Clostridiales orders associated with reduced risk of liver fibrosis. A bacterial consortium was subsequently tested in a mouse model of MASH, which demonstrated protective effects against …

Contrastive Learning With Transformer For Adverse Endpoint Prediction In Patients On Dapt Post-Coronary Stent Implantation, Fang Li, Zenan Sun, Ahmed Abdelhameed, Tiehang Duan, Laila Rasmy, Xinyue Hu, Jianping He, Yifang Dang, Jingna Feng, Jianfu Li, Yichen Wang, Tianchen Lyu, Naomi Braun, Si Pham, Michael Gharacholou, Delisa Fairweather, Degui Zhi, Jiang Bian, Cui Tao

Faculty, Staff and Student Publications

Background: Effective management of dual antiplatelet therapy (DAPT) following drug-eluting stent (DES) implantation is crucial for preventing adverse events. Traditional prognostic tools, such as rule-based methods or Cox regression, despite their widespread use and ease, tend to yield moderate predictive accuracy within predetermined timeframes. This study introduces a new contrastive learning-based approach to enhance prediction efficacy over multiple time intervals.

Methods: We utilized retrospective, real-world data from the OneFlorida + Clinical Research Consortium. Our study focused on two primary endpoints: ischemic and bleeding events, with prediction windows of 1, 2, 3, 6, and 12 months post-DES implantation. Our approach first …

Usp22 Overexpression Fails To Augment Tumor Formation In Mmtv-Erbb2 Mice But Loss Of Function Impacts Mmtv Promoter Activity, Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J Muller, Sharon Y R Dent, Evangelia Koutelou

Faculty, Staff and Student Publications

The Ubiquitin Specific Peptidase 22 (USP22), a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear. We reported previously that Usp22 loss in mice impacts execution of several signaling pathways driven by growth factor receptors such as erythroblastic oncogene B b2 (ERBB2). To determine whether changes in USP22 expression affects ERBB2-driven tumorigenesis, we introduced conditional overexpression or deletion alleles of Usp22 into mice bearing the Mouse mammary tumor virus-Neu-Ires-Cre (MMTV-NIC) transgene, which drives both rat ERBB2/NEU expression and Cre recombinase activity from the MMTV promoter resulting …

The Use Of Large Language Models To Accelerate Literature Review Towards Digital Health Equity And Inclusiveness, Taylor B Harrison, Dian Hu, Sunyang Fu, Hongfang Liu

Faculty, Staff and Student Publications

Digital health technologies (DHTs) have revolutionized clinical trials, offering unprecedented opportunities to streamline processes, enhance patient engagement, and improve data quality. Growing technology device and broadband access are contributing to the increasing number of DHT-enabled trials. Ideally, DHTs have the potential to make clinical research more inclusive and diverse. However, while the variety in digital technologies and implementations present a strong display of healthcare innovation, major challenges arise concerning DHT generalizability and translation into real-world medical practice. In this study, we report our efforts in accelerating the literature review process related to the use of DHTs in randomized controlled trials …

Interleukin-1beta And Inflammasome Expression In Spinal Cord Following Chronic Constriction Injury In Male And Female Rats, Suzanne M Green-Fulgham, Jayson B Ball, Andrew J Kwilasz, Michael E Harland, Matthew G Frank, Joseph M Dragavon, Peter M Grace, Linda R Watkins

Faculty, Staff and Student Publications

Females represent a majority of chronic pain patients and show greater inflammatory immune responses in human chronic pain patient populations as well as in animal models of neuropathic pain. Recent discoveries in chronic pain research have revealed sex differences in inflammatory signaling, a key component of sensory pathology in chronic neuropathic pain, inviting more research into the nuances of these sex differences. Here we use the chronic constriction injury (CCI) model to explore similarities and differences in expression and production of Inflammatory cytokine IL-1beta in the lumbar spinal cord, as well as its role in chronic pain. We have discovered …

Identifying Genomic Data Sources From Biomedical Literature, Xu Zuo, Ashley Gilliam, Yan Hu, Kalpana Raja, Kirk Roberts, Hua Xu

Faculty, Staff and Student Publications

Genomic research is becoming increasingly data-intensive, yet the proper reference of data remains a persistent challenge. Despite various efforts to establish and standardize data citation practices, scientists frequently fall short of accurately referencing data in their papers. This deficiency complicates the attribution of contributions to data providers and impedes the reproducibility of findings in genomic research. This study addresses this gap by introducing a gold standard corpus designed to identify mentions of genomic data sources and associated attributes, thereby offering insights into data source availability and accessibility. Within this corpus, we categorize entities into six classes, encompassing three primary entities …

Dissecting The Shared Genetic Architecture Between Alzheimer’S Disease And Frailty: A Cross-Trait Meta-Analyses Of Genome-Wide Association Studies, Nitesh Enduru, Brisa S Fernandes, Zhongming Zhao

Faculty, Staff and Student Publications

Introduction: Frailty is the most common medical condition affecting the aging population, and its prevalence increases in the population aged 65 or more. Frailty is commonly diagnosed using the frailty index (FI) or frailty phenotype (FP) assessments. Observational studies have indicated the association of frailty with Alzheimer's disease (AD). However, the shared genetic and biological mechanism of these comorbidity has not been studied.

Methods: To assess the genetic relationship between AD and frailty, we examined it at single nucleotide polymorphism (SNP), gene, and pathway levels.

Results: Overall, 16 genome-wide significant loci (15 unique loci) (p meta-analysis < 5 × 10-8) and 22 genes (21 unique genes) were identified between AD and frailty using cross-trait meta-analysis. The 8 shared loci implicated 11 genes: CLRN1-AS1, CRHR1 …

Metarnn: Differentiating Rare Pathogenic And Rare Benign Missense Snvs And Indels Using Deep Learning, Fang Li, Zenan Sun, Ahmed Abdelhameed, Tiehang Duan, Laila Rasmy, Xinyue Hu, Jianping He, Yifang Dang, Jingna Feng, Jianfu Li, Yichen Wang, Tianchen Lyu, Naomi Braun, Si Pham, Michael Gharacholou, Delisa Fairweather, Degui Zhi, Jiang Bian, Cui Tao

Faculty, Staff and Student Publications

BACKGROUND: Effective management of dual antiplatelet therapy (DAPT) following drug-eluting stent (DES) implantation is crucial for preventing adverse events. Traditional prognostic tools, such as rule-based methods or Cox regression, despite their widespread use and ease, tend to yield moderate predictive accuracy within predetermined timeframes. This study introduces a new contrastive learning-based approach to enhance prediction efficacy over multiple time intervals.

METHODS: We utilized retrospective, real-world data from the OneFlorida + Clinical Research Consortium. Our study focused on two primary endpoints: ischemic and bleeding events, with prediction windows of 1, 2, 3, 6, and 12 months post-DES implantation. Our approach first …

Polaris: A Phase 2 Trial Of Encorafenib Plus Binimetinib Evaluating High-Dose And Standard-Dose Regimens In Patients With Braf V600-Mutant Melanoma With Brain Metastasis, Alexander M Menzies, Georgina V Long, Amiee Kohn, Hussein Tawbi, Jeffrey Weber, Keith Flaherty, Grant A Mcarthur, Paolo A Ascierto, Yanina Pfluger, Karl Lewis, Katy K Tsai, Omid Hamid, Hans Prenen, Luis Fein, Erjian Wang, Carolin Guenzel, Fan Zhang, Joseph F Kleha, Alessandra Di Pietro, Michael A Davies

Faculty, Staff and Student Publications

Background: POLARIS (phase 2 [ph2]; NCT03911869) evaluated encorafenib (BRAF inhibitor) in combination with binimetinib (MEK1/2 inhibitor) in BRAF/MEK inhibitor-naïve patients with BRAF V600-mutant melanoma with asymptomatic brain metastases.

Methods: The safety lead-in (SLI) assessed tolerability for high-dose encorafenib 300 mg twice daily (BID) plus binimetinib 45 mg BID. If the high dose was tolerable in ph2, patients would be randomized to receive high or standard dose (encorafenib 450 mg once daily [QD] plus binimetinib 45 mg BID). Otherwise, standard dose was evaluated as the recommended ph2 dose (RP2D). Patients who tolerated standard dosing during Cycle 1 could be dose …

Association Of Preoperative Lung Function With Complications After Lobectomy Using Race-Neutral And Race-Specific Normative Equations, Ajay Sheshadri, Ravi Rajaram, Aaron Baugh, Mario Castro, Arlene M Correa, Felipe Soto, Carrie R Daniel, Liang Li, Scott E Evans, Burton F Dickey, Ara A Vaporciyan, David E Ost

Faculty, Staff and Student Publications

Rationale: Pulmonary function testing (PFT) is performed to aid patient selection before surgical resection for non-small cell lung cancer (NSCLC). The interpretation of PFT data relies on normative equations, which vary by race, but the relative strength of association of lung function using race-specific or race-neutral normative equations with postoperative pulmonary complications is unknown. Objectives: To compare the strength of association of lung function, using race-neutral or race-specific equations, with surgical complications after lobectomy for NSCLC.

Methods: We studied 3,311 patients who underwent lobectomy for NSCLC and underwent preoperative PFT from 2001 to 2021. We used Global Lung Function Initiative …

Interactions Between Non‐Native Western Mosquitofish And Native Bluegill Sunfish: Mesocosm Experiments, Jessica E. Rettig, Elizabeth P. Tristano, Anthony C. Burger, Geoffrey R. Smith

Faculty Publications

No abstract provided.