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Independent Regulation Of Piezo1 Activity By Principal And Intercalated Cells Of The Collecting Duct, Kyrylo Pyrshev, Anna Atamanchuk-Stavniichuk, Mariya Kordysh, Oleg Zaika, Viktor N Tomilin, Oleh Pochynyuk

Faculty, Staff and Student Publications

The renal collecting duct is continuously exposed to a wide spectrum of fluid flow rates and osmotic gradients. Expression of a mechanoactivated Piezo1 channel is the most prominent in the collecting duct. However, the status and regulation of Piezo1 in functionally distinct principal and intercalated cells (PCs and ICs) of the collecting duct remain to be determined. We used pharmacological Piezo1 activation to quantify Piezo1-mediated [Ca2+]i influx and single-channel activity separately in PCs and ICs of freshly isolated collecting ducts with fluorescence imaging and electrophysiological tools. We also employed a variety of systemic treatments to examine their consequences on Piezo1 …

Rare Genomic Copy Number Variants Implicate New Candidate Genes For Bicuspid Aortic Valve, Steven G Carlisle, Hasan Albasha, Hector I Michelena, Anna Sabate-Rotes, Lisa Bianco, Julie De Backer, Laura Muiño Mosquera, Anji T Yetman, Malenka M Bissell, Maria Grazia Andreassi, Ilenia Foffa, Dawn S Hui, Anthony Caffarelli, Yuli Y Kim, Dongchuan Guo, Rodolfo Citro, Margot De Marco, Justin T Tretter, Kim L Mcbride, Dianna M Milewicz, Simon C Body, Siddharth K Prakash, Ebav Investigators, Bavcon Investigators

Faculty, Staff and Student Publications

Bicuspid aortic valve (BAV), the most common congenital heart defect, is a major cause of aortic valve disease requiring valve interventions and thoracic aortic aneurysms predisposing to acute aortic dissections. The spectrum of BAV ranges from early onset valve and aortic complications (EBAV) to sporadic late onset disease. Rare genomic copy number variants (CNVs) have previously been implicated in the development of BAV and thoracic aortic aneurysms. We determined the frequency and gene content of rare CNVs in EBAV probands (n = 272) using genome-wide SNP microarray analysis and three complementary CNV detection algorithms (cnvPartition, PennCNV, and QuantiSNP). Unselected control …

Reporting Quality Of Endoscopic Colorectal Cancer Screening Randomized Controlled Trials: Adherence To Recommendations And Interventions, Fouad Jaber, Khalid Ahmed, Osama Hamid, Willie Mohammed Johnson, Saqr Alsakarneh, Abubaker O Abdalla, Yazan Abboud, Mouhand Mohamed, Dushyant Singh Dahiya, Shifa Umar, Mohamed Abdallah, Mohammad Bilal, Aasma Shaukat

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: In 2013, the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) steering group published recommendations to standardize reporting quality in randomized controlled trials (RCTs). We aim to assess adherence to SPIRIT reporting guidelines in RCTs on endoscopic colorectal cancer (CRC) screening and participants' adherence to trial protocols.

METHODS: We searched databases for RCTs evaluating flexible sigmoidoscopy or colonoscopy for CRC screening published in English language through September 2023. Each eligible study was evaluated using the 8 core SPIRIT statement areas, totaling 51 points. Each item received 1 point if it met the criteria and 0 points if …

The Immunobiology Of Myelodysplastic Neoplasms: A Mini-Review, Shruthi Kannan, Rolando A Vedia, Jeffrey J Molldrem

Faculty, Staff and Student Publications

This mini review summarizes the immunobiology of myelodysplastic syndromes, specifically focusing on the interactions between immune cells, cytokines, and dysplastic cells within the tumor microenvironment in the bone marrow. We elucidate in detail how immune dysregulation and evasion influence the initiation and progression of myelodysplastic syndromes, as well as resistance to therapy and progression to AML. In addition, we highlight a range of therapeutic strategies, including the most recent breakthroughs and experimental therapies for treating MDS. Finally, we address the existing knowledge gaps in the understanding of the immunobiology of MDS and propose future research directions, promising advancements toward enhancing …

Nasal Bots Carry Relevant Titers Of Cwd Prions In Naturally Infected White-Tailed Deer, Paulina Soto, Francisca Bravo-Risi, Carlos Kramm, Nazaret Gamez, Rebeca Benavente, Denise L Bonilla, J Hunter Reed, Mitch Lockwood, Terry R Spraker, Tracy Nichols, Rodrigo Morales

Faculty, Staff and Student Publications

Chronic wasting disease (CWD) is a prion disease affecting farmed and free-ranging cervids. CWD is rapidly expanding across North America and its mechanisms of transmission are not completely understood. Considering that cervids are commonly afflicted by nasal bot flies, we tested the potential of these parasites to transmit CWD. Parasites collected from naturally infected white-tailed deer were evaluated for their prion content using the protein misfolding cyclic amplification (PMCA) technology and bioassays. Here, we describe PMCA seeding activity in nasal bot larvae collected from naturally infected, nonclinical deer. These parasites efficiently infect CWD-susceptible mice in ways suggestive of high infectivity …

Prompt, Accurate, And Noncontact Material Identification Using A Single Microwave Sensor With Machine Learning Analysis, Chen Zhu, Osamah Alsalman, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

In This Article, a Novel Approach to Microwave Sensors is Proposed and Demonstrated that Allows for Prompt, Accurate, and Noncontact Material Identification Even with Arbitrary Lift-Off Distances between the Sensor and the Material under Test (MUT). a Multilayer Perceptron (MLP) is Trained to Directly Learn the Relation of the Measured Reflection Spectra of a Homemade Open-Ended Coaxial Cable Resonator Probe with Respect to Different MUTs and Then Achieve One-To-One Mapping between a Measured Spectrum and the MUT. as a Proof-Of-Concept Demonstration, the Performance of the MLP Model is Tested using Easily Accessible Materials, Including Wood, Glass, Water, and Metal. Reflection …

Impact Of Ai On The Hri Dynamic In Search And Rescue Operations Using Uav Swarms, Jordan Morrow, Maciej Jan Zawodniok, Anhar Sami Mohammed

Electrical and Computer Engineering Faculty Research & Creative Works

Artificial intelligence (AI) offers significant benefits in search and rescue applications by enhancing the efficiency and effectiveness of the search. However, an over-reliance on AI can hinder the operation due to biases embedded in the underlying algorithms. This partiality, if left un-monitored, can pose a risk to the safety of those in need of disaster relief. Typically manifests into inaccuracies in the decision-making processes and if not carefully monitored can cause larger issues. This paper extends the knowledge presented in a previous work, which presents the design and modeling of search and rescue operations using unmanned aerial vehicle (UAV) swarms. …

High-Sensitivity Fabry-Perot Interferometric Sensor Based On Microwave Photonics With Phase Demodulation, Ruimin Jie, Hongkun Zheng, Osamah Alsalman, Jie Huang, Chen Zhu

Electrical and Computer Engineering Faculty Research & Creative Works

Optical fiber sensors have emerged as vital tools in various applications. Among them, Fabry-Perot interferometers (FPIs), have gained prominence due to their compactness and versatility in sensor design. Microwave photonics (MWP) techniques offer enhanced performance and flexibility for developing optical sensor interrogation methods. This paper proposes and experimentally demonstrates a novel MWP interrogation technique based on phase measurement for short-cavity FPI sensors. The technique utilizes the phase response of the FPI sensor within an MWP-assisted single radio frequency bandpass filter, providing improved sensitivity and dynamic sensing capabilities compared to traditional methods. Simulation and experimental results validate the effectiveness of the …

Design Of The Tm010 Mode Cylindrical Cavity Resonator For Pcb Dielectric Characterization, Reza Asadi, Chaofeng Li, Seyedmehdi Mousavi, Seyed Moastafa Mousavi, Reza Vahdani, Xiaoning Ye, Donghyun Kim

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents the study of the TM₀₁₀ mode cylindrical resonator, which can be used for printed circuit board (PCB) material properties extraction, e.g., the dielectric constant (Dk) and the loss tangent (Df) extraction. The theoretical formulas of the resonance frequency and Q-factor of the resonator are presented. In real measurement, the TM₀₁₀ mode cylindrical cavity resonator needs to be excited by the probe. The study emphasizes the impact of probe orientation, location, and field distribution on the accuracy of material property extraction. The relationship between cavity dimensions and resonance frequency is explored, highlighting the influence of cavity …

Lifelong Direct Error-Driven Learning For Uav Altitude Estimation In Different Weather Conditions, Shirin Nasr-Esfahani, Jagannathan Sarangapani

Electrical and Computer Engineering Faculty Research & Creative Works

While deep neural networks achieve remarkable visual perception capabilities for UAV position and orientation estimation, their resilience to different weather conditions still needs improvement. These models often suffer from catastrophic forgetting when adapted to new environments, losing previously acquired knowledge. Lifelong learning methods aim to balance learning flexibility and memory stability. In this paper, we present an image-based approach to estimate the relative altitude of a UAV using 2D images under varying weather conditions, including sunny, sunset, and foggy scenarios. Our experiments demonstrate significant performance degradation when the model is trained sequentially on different weather datasets, especially when new images …

Cape Playhouse, Program, Cape Cod, Massachusetts, 1955

Documents

Program for Richard Aldrich's Cape Playhouse, "Americas Most Famous Summer Theatre," Dennis on Cape Cod, Massachusetts, 29th season, week of July 18, 1955.

Shirley Booth in "The Time of the Cuckoo" by Arthur Laurents, directed by Dan Levin, and Eva Marie Saint in "The Rainmaker" directed by Jeffrey Hayden.

The Plymouth Theatre, Playbill, New York, New York, 1936

Documents

Playbill for "Pride and Prejudice," at The Plymouth Theatre, New York, beginning 1936 April 20. "A Sentimental Comedy in Three Acts, Dramatized by Helen Jerome from the Jane Austen novel with Adrianne Allen, Colin Keith-Johnston, Lucile Watson, and Percy Waram, Staged by Robert Sinclair."

Playhouse On The Square, Program, Memphis, Tennessee, 1981

Documents

Playhouse on the Square, program for "Frankenstein" by Tim Kelly, directed by Ron Wachholtz, Memphis, Tennessee, 1981 January 22-February 20.

The Oswald Review Of Undergraduate Research And Criticism In The Discipline Of English: Volume 26, 2024, Douglas Higbee

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Colonial Body-Logic In George Orwell's Burnese Days: A Contrapuntal Critique, Riley Mays

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Tenncare's Fiscal Year 22-23 Annual Report, Tennessee. Department Of Human Services.

TennCare Annual Report

No abstract provided.

Laboratory Evaluation Of Essential Oils Extracted From Peppermint And Eucalyptus Plants Against The Rat Flea (Xynopsylla Cheopis) And Evaluate Their Effects On Some Vital Process In Albino Rat, Rasha Ragheb Hassan, Micheal William Mikhail

Journal of Medicine in Scientific Research

The effectiveness of peppermint and eucalyptus oils was examined in the current study to the rat fleas (Xenopsylla cheopis). The constituents of each oil were identified by GC-MS. The LC50 and LC90 for each essential oil were calculated after 1 and 24 hours exposure. The effect of peppermint and eucalyptus oils on some vital process in albino rat treated with 1/10 and 1/20 of LD50 were studied for the ALT, AST, Urea and creatinine levels. TNF-α and IL-6 levels also were studied. Data indicated that peppermint essential oil had more efficacy than that of eucalyptus for 1 and 24 hours …

Evaluation Of Iron, Zinc And Vitamin D Deficiencies In Children With Autism Spectrum Disorder At The Hearing And Speech Institute, In Egypt, Azza Samy, Iman Elrouby, Eman S. Eldin, Eman S. Abd El-Ghaffar

Journal of Medicine in Scientific Research

Background Autism spectrum disorder (ASD) is a complex neurodevelopment disorder with a multifactorial etiology. Each iron, zinc and vitamin D are essential for cognitive, behavioral and motor development. Deficiency of any of these micronutrients may affect ASD symptoms.

Objective The aim of this study is to evaluate and compare the level of iron, zinc and vitamin D levels in children with autism spectrum disorder (ASD) with normal children and to associate between the deficiency of these nutrient elements and the severity of ASD symptoms, in order to help in improvement of ASD symptoms by supplying the deficient elements.

Patients and …

In Pursuit Of Equity Under Nepa: Apalachicola’S Invisibility In The Tristate Water Wars, Abigail E. Andre

University of Memphis Law Review

In the presence of significant environmental impacts, the National Environmental Policy Act (“NEPA”) requires agencies to take a hard look at community effects. However, analysis of human impacts under NEPA is generally cursory. While executive orders requiring consideration of environmental justice have raised awareness of community impacts in some instances, agency approach is inconsistent, and courts largely view such analysis as a box to be checked. Such cursory consideration of human impacts leaves historically underserved communities in a legal blind spot that perpetuates environmental and procedural inequity. Using the U.S. Army Corps of Engineers’ management of the Apalachicola, Chattahoochee, and …

Prediction Interpretations Of Ensemble Models In Chronic Kidney Disease Using Explainable Ai, K M Tawsik Jawad

Browse all Theses and Dissertations

Chronic Kidney Disease (CKD) poses significant health and financial threat to millions of patients all around the world. The irreversible nature of this disease not just leads to comorbid diseases like Diabetes Mellitus, Hypertension, Anemia, Bone Disease, Neurological Implants etc. It can permanently damage the kidney by progressing to Acute Kidney Injury (AKI) or End Stage Renal Diseases (ESRD). The risk factors of CKD become more dangerous as patients suffering from it have little to no idea about the presence of CKD in their body until it takes the shape of AKI or ESRD. There are severe economic burdens for …

What A Waste: Nitrogen Runoff And Rates In The Maumee River (Ohio, Usa), Ryanne Antonette Cimatu

Browse all Theses and Dissertations

Excess anthropogenic nitrogen (N), primarily from agricultural field fertilization, causes nutrient runoff that stimulates harmful algal blooms (HABs) in western Lake Erie. As a critical tributary to Lake Erie, nutrient loading from the Maumee River drives the intensity of the annual summer HABs in the western basin. Knowledge gaps around rates of N transformations in the Maumee River currently hinder the calibration of in-river parameters in Soil and Water Assessment Tool (SWAT) models for the Maumee watershed. To address these gaps, this research quantified rates of ammonium uptake, ammonium remineralization, nitrification, and bacterial respiration alongside physicochemical parameters of the river. …

Biomechanical Simulation Of Cardiovascular Implantable Electronic Device Leads With Residual Properties, Anmar Mahdi Salih

Browse all Theses and Dissertations

Implantable leads used in pacemakers, defibrillators, and cardiac resynchronization therapy are designed for in-vivo applications, yet their longevity is inevitably shaped by the conditions within the human body. The mechanical behavior of these leads can be affected over time, necessitating the evaluation of their residual properties. Two main insulators, silicone, and polyurethane are commonly used for the outer insulation of cardiac leads. Understanding the long-term performance of these insulators is crucial for ensuring the reliability and safety of cardiac implantable devices. The research aims to assess the long-term mechanical properties and performance of implantable leads utilized in cardiovascular implantable electronic …

A Spectrophotometric Determination Of Strontium Complexation With Methylthymol Blue, Adebayo Comlan Djanman

Browse all Theses and Dissertations

This study examines the complexation behavior of methylthymol blue (MTB) with strontium, particularly focusing on its application in addressing environmental concerns related to radiotoxic 90Sr. Using spectrophotometric techniques, the binding interactions were analyzed at pH = 7.50, 9.60, and 12.20. Results indicate that MTB forms a 1:1 complex with strontium at pH = 7.50, while at pH = 9.60 and 12.20 were assumed to influence complexation due to changes in ligand deprotonation and electrostatic interactions. Equilibrium constants (K1) = 22 (± 2) and molar absorptivities, ε1 = 6.3 x 10^3 (± 0.0008) L·mol⁻¹·cm⁻¹, and ε2 = 9.73 x (± 0.2)10^3 …

Application Of Hot-Melt Extrusion Technology For The Preparation Of Carbamazepine Extended-Release Tablets, Chamundeswara Srinivasa Akash Kalla

Electronic Theses and Dissertations

Carbamazepine (CBZ) is an anti-convulsant and specific analgesic for trigeminal neuralgia that reduces polysynaptic responses and blocks post titanic potentiation. Moreover, CBZ is effective in partial and generalized convulsions and mixed types. It is not effective in petit mal seizures. Carbamazepine extended-release tablets are used to treat episodes of mania (or) mixed episodes i.e., symptoms of mania and depression that happen at the same time, in patients with bipolar disorder. The present study was designed to develop CBZ extended-release tablets with acrylic acid-based polymer (Eudragit® RL PO) using a melt granulation and to match the USP dissolution test specification. Thermal …

Mapping In/Exclusion: Queer Identity In Oxford, Mississippi, Julia Kraus

Electronic Theses and Dissertations

This thesis employs a mixed methods approach to investigate LGBTQ communities in Oxford, Mississippi, within the unique context of the Bible Belt panopticon. Through an examination of the Unitarian Universalist Congregation of Oxford (UUCO) and Oxford Pride, the study delves into the themes of visibility and surveillance, resistance and subversion, community and identity, and institutional interactions and impacts. The research is grounded in seven original interviews with UUCO members, providing nuanced insights into the functioning of LGBTQ communities within a conservative environment. Additionally, the creation of a podcast episode titled “Queering Oxford: the Long Path to Pride” offers an innovative …

Evaluation Of Process Parameters For Continuous Manufacturing Of Quetiapine Fumarate Immediate Release Tablets Using Twin Screw Wet Granulation, Tejaswini Naguboyina

Electronic Theses and Dissertations

Granulation is one of the important unit operations in the manufacturing of solid dosage forms like tablets and capsules that regulate the quality of end products. It is a process of particle enlargement by agglomeration technique, which improves flow properties, compressibility, reduction of dust formation, drug content uniformity, dissolution rates, and overall product stability. Traditionally, it has been a batch process due to a better understanding. However, there has been a shift towards continuous manufacturing using a Twin-screw granulator, which is more robust, scalable, and versatile for various applications. This work presents the use of Twin screw wet granulation (TSWG) …

Montesquieu: The Nature Of L’Esprit Des Lois, Christian Jax Murray

Electronic Theses and Dissertations

When Baron de Montesquieu received a copy of his L’Esprit des lois, he was horrified by the total removal and reorganization of critical parts of his text, changed ideas, and an abnormal amount of printing errors in his work. While he saw these issues hindering the reception of his work, this thesis argues that the chaos of the text, in both its style and publication, made the book more popular instead of hindering it. Montesquieu, his editor, and his publisher constructed a new kind of text that was broad in its subject matter and ambiguous in its meaning where its …

Modeling The Relationship Between Protein Sequence And Structure Using Triangular Spatial Relationship-Based Keys, Arianna Nicole Swensen

Electronic Theses and Dissertations

Protein structure comparison and our understanding of protein sequence and structure relationships are intertwined. In this work, I use the TSR-based key generation algorithm to develop a model for relating sequence and structure. I develop embeddings for the sequence-based keys and the structure-based keys as the basis for a translation model between the two sets of keys, evaluating the efficacy of local and global embedding generation techniques in the context of the TSR-based comparison method.

Investigation Of Evolution In Fungal Traits At Multiple Genetic Scales, Brooke Allen

Electronic Theses and Dissertations

The study of fungal traits is critical for understanding community assembly and ecosystem function, as traits related to resource acquisition, enemy avoidance, and stress tolerance link fungi to their ecological roles. Symbiotic relationships, such as those between ectomycorrhizal (EcM) fungi and their host plants, greatly influence fungal traits and play a key role in fungal evolution. In this study, we addressed the evolution of EcM fungal traits, particularly biosynthetic gene clusters (BGCs), at multiple genetic scales, including individual genes, genotypes within populations, and a broader phylogenetic perspective across the fungal kingdom. First, we surveyed the diversity of BGCs in native …

Development Of Multiple Dosage Forms Using Fused Deposition Modeling 3d Printing Coupled With Hot-Melt Extrusion Dissertation, Peilun Zhang

Electronic Theses and Dissertations

This dissertation explores the integration of Hot Melt Extrusion (HME) and Fused Deposition Modeling (FDM) 3D printing as a novel continuous manufacturing process for pharmaceutical dosage forms. Emphasizing the creation of personalized and complex drug delivery systems, this work highlights the potential of 3D printing technology in revolutionizing pharmaceutical manufacturing by offering customized dosage, precise API distribution, and efficient production with minimal waste. The first chapter delves into the fabrication of bilayer tablets utilizing HME in conjunction with dual-nozzle FDM 3D printing, examining the mechanical properties of HME filaments and the printing quality through a novel 3D printed tablet retention …