Digital Commons Network^™

Illuminating Function And Enabling Inhibition At The Protein-Membrane Interface Of Glutathione Peroxidase 4., Courtney L. Labrecque

Theses and Dissertations

Membrane proteins act as gateways to cells and are responsible not only for signaling, lipid transport, and cellular homeostasis, but they are also integral in disease pathologies. One class of membrane proteins, peripheral membrane proteins (PMPs), reside in aqueous compartments of the cell until they are recruited to the membrane to perform their function. Glutathione peroxidase 4 (GPx4) is a PMP enzyme responsible for engaging the membrane and reducing lipid hydroperoxides, thereby preventing cellular death via ferroptosis. Due to its central function surrounding ferroptosis, GPx4 is an interesting drug target that has recently gained interest for inflammatory diseases as well …

Latent Profiles Of Child Coping And Perception Of Experience Processes To Predict Long-Term Symptoms Of Depression, Intrusive Grief, And Suicidality Outcomes In Parentally Bereaved Children, Rebecca Hoppe

Theses and Dissertations

Childhood bereavement is a significant public health issue and the most distressing form of childhood trauma. The death of a parent can disrupt the course of a children's development and potentially predispose them to enduring adverse mental health outcomes, such as depression, intrusive grief, and suicidality. Recognizing grief as a dynamic process, theories have suggested that children’s unique coping and perceptions of experience can contribute to variations in individual adaptations to the death and the onset of mental health problems. The goals of this study were to (a) use latent profile analysis to empirically group recently bereaved children into distinct …

Assessing Relocation Habitats And Assisted Migration Of The Lassics Lupine, An Endangered California Serpentine-Endemic, Caitlyn M. Allchin

Cal Poly Humboldt theses and projects

The Lassics lupine, Lupinus constancei, is a serpentine species endemic to the Lassics Mountains of northern California, listed as critically imperiled and federally endangered. Increased encroachment from reduced fire intervals has led to elevated herbivory from small mammals. While deployment of exclosure cages has decreased negative impacts, diminishing snowpack from shifting climate continues to threaten the Lassics lupine. To locate possible refugia, I evaluated alternative sites for assisted migration. I built a habitat suitability model (HSM) using MaxEnt software and WorldClim variables to predict optimal habitat. I then evaluated aerial imagery, topography, and geology to identify areas for microhabitat …

Characterizing The Beneficial Uses Of The Arcata Marsh Constructed Wetland Treatment System And Wildlife Sanctuary, Andrew S. Wolff

Cal Poly Humboldt theses and projects

The Arcata Marsh Constructed Wetland Treatment System and Wildlife Sanctuary, located in Arcata California, has been in operation since 1986. Not only has it served as the wastewater treatment facility for the city, it has also provided other beneficial uses such as acting as a sanctuary for bird, mammal, amphibian, and macroinvertebrate species. With facility upgrades currently underway, it has become important to revisit the beneficial uses of the Arcata Marsh. This project aimed to identify and characterize these beneficial uses. Literature review was conducted, and eleven beneficial uses were identified. Existing and newly obtained data were analyzed to characterize …

Environmental Implications Of Modern Food Production: An Analysis For The Conscious Consumer, Jessica T. Coming

Cal Poly Humboldt theses and projects

This project explores the pathways by which agriculture affects the environment and determines which foods have the greatest climate, water, and land impacts. Agricultural effects on the environment are extensive, from loss of habitat and declines in regional biodiversity to disruption of global nutrient cycles and climate change. Global food production accounts for 26-34% of annual anthropogenic greenhouse gas emissions, makes up 38-46% of habitable land, and is responsible for 70% of freshwater extraction. The effect of agriculture on the environment is most significantly dictated by what type of food is being produced. Animal-based food products consistently have the highest …

Pond Characteristics That Influence Oviposition Site Selection By Two Pond-Breeding Amphibians, Northern Red-Legged Frog (Rana Aurora) And Northwestern Salamander (Ambystoma Gracile), Jessica Jones

Cal Poly Humboldt theses and projects

Pond-breeding amphibians connect aquatic and terrestrial habitats through their biphasic life cycle, and understanding pond characteristics that support oviposition sites for multiple species is important for amphibian conservation. Two common amphibians in the Pacific Northwest, Northern red-legged frog (Rana aurora) and Northwestern salamander (Ambystoma gracile) often oviposit in the same pond; however, prior studies have focused on pond use by one species or the other, but not both together. I surveyed pond and oviposition site characteristics of 26 ponds in Humboldt County, CA, 10 of which were used only by R. aurora and 16 of which …

Characterizing New Plant Fossils With Woody Growth From The Battery Point Formation Of Quebec (Canada), Emma T. Casselman

Cal Poly Humboldt theses and projects

The oldest woody growth has been recognized in several Early Devonian (ca. 410-395 Ma) euphyllophytes. Their taxonomic diversity is difficult to evaluate due to a lack of quantitative methods for comparing plants based on secondary xylem anatomy. In turn, this hinders understanding of their implications for the evolution of plant development. To develop metrics that quantify secondary xylem anatomy and allow for conclusive comparisons, I investigated extant taxa and Early Devonian fossil woody taxa. I developed multiple metrics for quantifying tracheid size as a function of position in the secondary xylem and tested them on a dataset of extant gymnosperms. …

A Post-Colonial Criticism Of Ernest Callenbach's Ecotopia, Kaitlyn R. O'Dell

Cal Poly Humboldt theses and projects

The representation of Indigenous land-based cosmologies within Ernest Callenbach’s Ecotopia communicates a real perception of our world through the constructed imaginative society within this speculative fiction novel. Ecotopia is an alternative Pacific West Coast society that counters the dominant United States model in its holistic and green approach. This green society relies heavily on Indigenous ideology but lacks actual Indigenous voices or communities within this white idealized society. This research provides an example of the deconstruction of this popular novel to its main problematic components, establishing why the use of Indigenous beliefs and values can cause negative implications to the …

"Kindness Eases Change / Love Quiets Fear": Mapping Change And Movement In Octavia Butler's Parable Of The Sower, Elizabeth Hershey

Cal Poly Humboldt theses and projects

In this project I take a digital mapping approach to reading and analyzing Octavia Butler’s Parable of the Sower. A lot has been said about this novel’s relevance to our own world, and the ways it forces us to think about possible futures. To contribute to the conversations surrounding this novel, I add a digital humanities element to the conversation in order to see what digital mapping has to offer in the way of literary analysis and connecting this novel to our own world. Since the novel is so focused on movement and change, I mapped out the movement of …

Domestic Supply (A Feminist Proposal), Jennifer S. Hendricks

Publications

No abstract provided.

The Cost Of Providing Care By Family And Friends (Informal Care) In The Last Year Of Life: A Population Observational Study, Miriam J. Johnson, David C. Currow, Jade Chynoweth, Helen Weatherly, Gamze Keser, Ann Hutchinson, Annie Jones, Laurie Dunn, Victoria Allgar

Peninsula Medical School

Introduction: Little is known about replacement costs of care provided by informal carers during the last year of life for people dying of cancer and non-cancer diseases. Aim: To estimate informal caregiving costs and explore the relationship with carer and decedent characteristics. Design: National observational study of bereaved carers. Questions included informal end-of-life caregiving into the 2017 Health Survey for England including estimated recalled frequency, duration and intensity of care provision. We estimated replacement costs for a decedent’s last year of life valuing time at the price of a substitutable activity. Spearman rank correlations and multivariable linear regression were used …

Shift In Algal Blooms From Micro‐ To Macroalgae Around China With Increasing Eutrophication And Climate Change, Yuan Feng, Yonglong Xiong, Jm Hall‐Spencer, Kailin Liu, John Beardall, K Gao, Jingke Ge, Juntian Xu, G Gao

School of Biological and Marine Sciences

Blooms of microalgal red tides and macroalgae (e.g., green and golden tides caused by Ulva and Sargassum) have caused widespread problems around China in recent years, but there is uncertainty around what triggers these blooms and how they interact. Here, we use 30 years of monitoring data to help answer these questions, focusing on the four main species of microalgae Prorocentrum donghaiense, Karenia mikimotoi, Noctiluca scintillans, and Skeletonema costatum) associated with red tides in the region. The frequency of red tides increased from 1991 to 2003 and then decreased until 2020, with S. costatum red tides exhibiting the highest rate …

Quantitative Comparison Of Presenilin Protein Expression Reveals Greater Activity Of Ps2-Γ-Secretase, Melissa K. Eccles, Nathan Main, Rodrigo Carlessi, Ayeisha M. Armstrong, Miheer Sabale, Brigid Roberts-Mok, Janina E. E. Tirnitz-Parker, Mark Agostino, David Groth, Paul E. Fraser, Giuseppe Verdile

Research outputs 2022 to 2026

γ-secretase processing of amyloid precursor protein (APP) has long been of interest in the pathological progression of Alzheimer's disease (AD) due to its role in the generation of amyloid- . The catalytic component of the enzyme is the presenilins of which there are two homologues, Presenilin-1 (PS1) and Presenilin-2 (PS2). The field has focussed on the PS1 form of this enzyme, as it is typically considered the more active at APP processing. However, much of this work has been completed without appropriate consideration of the specific levels of protein expression of PS1 and PS2. We propose that expression is an …

Explainability And Understandability Of Artificial Neural Networks, Jan Stodt

School of Engineering, Computing and Mathematics Theses

Artificial Neural Networks (ANNs) have achieved significant success in fields likehealthcare, but their "black box" nature challenges transparency and user trust.Existing Explainable AI (XAI) methods aim to interpret ANN decisions, yet manyare not understandable to non-AI-experts, emphasizing the need for approachesthat prioritize both accuracy and usability, especially in high-stakes environments.This thesis investigates the reliability and usability of selected existing XAI meth-ods, evaluating how effectively they convey meaningful explanations to users withAI varying expertise. Assessments of methods like LIME, GradCAM, and Fast-CAM identify key limitations, such as inconsistent visual saliency maps and a lackof user-centred design. These findings underpin the need …

Investigation Of Campylobacter Concisus Gastric Epithelial Pathogenicity Using Ags Cells, Christopher Y. M. Luk, Seul A. Lee, Nicholas Naidovski, Fang Liu, Alfred C. Y. Tay, Liang Wang, Stephen Riordan, Li Zhang

Research outputs 2022 to 2026

Campylobacter concisus is an oral bacterium. Recent studies suggest that C. concisus may be involved in human gastric diseases. The mechanisms, however, by which C. concisus causes human gastric diseases have not been investigated. Here we examined the gastric epithelial pathogenicity of C. concisus using a cell culture model. Six C. concisus strains and the human gastric epithelial cell line AGS cells were used. IL-8 produced by AGS cells after incubation with C. concisus was measured using enzyme-linked immunosorbent assay (ELISA), and AGS cell apoptosis was determined by caspase 3/7 activities. The effects of C. concisus on actin arrangement in …

Region-Specific Drivers Cause Low Organic Carbon Stocks And Sequestration Rates In The Saltmarsh Soils Of Southern Scandinavia, Carmen Leiva-Dueñas, Anna E. L. Graversen, Gary T. Banta, Jeppe N. Hansen, Marie L. K. Schrøter, Pere Masqué, Marianne Holmer, Dorte Krause-Jensen

Research outputs 2022 to 2026

Saltmarshes are known for their ability to act as effective sinks of organic carbon (OC) and their protection and restoration could potentially slow down the pace of global warming. However, regional estimates of saltmarsh OC storage are often missing, including for the Nordic region. To address this knowledge gap, we assessed OC storage and accumulation rates in 17 saltmarshes distributed along the Danish coasts and investigated the main drivers of soil OC storage. Danish saltmarshes store a median of 10 kg OC m−2 (interquartile range, IQR: 13.5–7.6) in the top meter and sequester 31.5 g OC m−2 yr−1 (IQR: 41.6–15.7). …

A Systematic Review Of K-12 Cybersecurity Education Around The World, Ahmed Ibrahim, Marnie Mckee, Leslie F. Sikos, Nicola F. Johnson

Research outputs 2022 to 2026

This paper presents a systematic review of K-12 cybersecurity education literature from around the world. 24 academic papers dated from 2013-2023 were eligible for inclusion in the literature established within the research protocol. An additional 19 gray literature sources comprised the total. A range of recurring common topics deemed as aspects of cybersecurity behavior or practice were identified. A variety of cybersecurity competencies and skills are needed for K-12 students to apply their knowledge. As may be expected to be the case with interdisciplinary fields, studies are inherently unclear in the use of their terminology, and this is compounded in …

Airway Epithelium Respiratory Illnesses And Allergy (Aerial) Birth Cohort: Study Protocol, Elizabeth Kicic-Starcevich, David G. Hancock, Thomas Iosifidis, Patricia Agudelo-Romero, Jose A. Caparros-Martin, Yuliya V. Karpievitch, Desiree Silva, Lidija Turkovic, Peter N. Le Souef, Anthony Bosco, David J. Martino, Anthony Kicic, Susan L. Prescott, Stephen M. Stick

Research outputs 2022 to 2026

Introduction: Recurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium plays a central role in the pathogenesis of recurrent wheeze, although the underlying mechanisms are still not fully understood. This prospective birth cohort aims to bridge this knowledge gap by investigating the influence of intrinsic epithelial dysfunction on the risk for developing respiratory disorders and the modulation of this risk by maternal morbidities, in utero exposures, and respiratory exposures …

“We’Ve All Come Together”: A Board Game Intervention For Children And Adults With Autism And Other Developmental Disabilities, Gray Atherton, Emily Dawson, Liam Cross

School of Psychology

The authors discuss how board games offer individuals with autism (whooften struggle with social settings and require structured outlets for building relationships) an affordable, naturalistic, collaborative environmentthat is stimulating, engaging, and educational. Board games, they assert,provide opportunities to practice social skills, including cooperation andsocial deduction, essential skills for both neurotypical and atypical people.The authors include recommendations for introducing board games intospecial educational settings. K

Investigation And Modelling Of A Cortical Learning Algorithm In The Neocortex, Damir Dobric

School of Engineering, Computing and Mathematics Theses

Many algorithms today provide a good machine learning solution in the specific problem domain, like pattern recognition, clustering, classification, sequence learning, image recognition, etc. They are all suitable for solving some particular problem but are limited regarding flexibility. For example, the algorithm that plays Go cannot do image classification, anomaly detection, or learn sequences. Inspired by the functioning of the neocortex, this work investigates if it is possible to design and implement a universal algorithm that can solve more complex tasks more intelligently in the way the neocortex does. Motivated by the remarkable replication degree of the same and similar …

Labembryocam: An Opensource Phenotyping System For Developing Aquatic Animals, Ziad Ibbini, Maria Bruning, Sakina Allili, Luke A. Holmes, Ellen Tully, Jamie Mccoy, Benjamin Larsen, Tony Wilson, Guy Ludford, Jack Barrett-Kelly, John I. Spicer, Oliver Tills

School of Biological and Marine Sciences

Phenomics is the acquisition of high-dimensional data on an individual-wide scale and is proving transformational in areas of biological research related to human health including medicine and the crop sciences. However, more broadly, a lack of accessible transferrable technologies and research approaches is significantly hindering the uptake of phenomics, in contrast to molecular-omics for which transferrable technologies have been a significant enabler. Aquatic embryos are natural models for phenomics, due to their small size, taxonomic diversity, ecological relevance, and high levels of temporal, spatial and functional change. Here, we present LabEmbryoCam, an autonomous phenotyping platform for timelapse imaging of developing …

Contrasting Species-Specific Stress Response To Environmental Ph Determines The Fate Of Coccolithophores In Future Oceans, Nishant Chauhan, Craig J. Dedman, Chloë Baldreki, Adam A. Dowle, Tony R. Larson, Rosalind E.M. Rickaby

School of Geography, Earth and Environmental Sciences

Molecular mechanisms driving species-specific environmental sensitivity in coccolithophores are unclear but crucial in understanding species selection and adaptation to environmental change. This study examined proteomic and physiological changes in three species under varying pH conditions. We showed that changing pH drives intracellular oxidative stress and changes membrane potential. Upregulation in antioxidant, DNA repair and cell cycle-related protein-groups indicated oxidative damage across high (pH 8.8) and low pH (pH 7.6) compared to control pH (pH 8.2), and correlated with reduced growth rates. Upregulation of mitochondrial proteins suggested higher metabolite demand for restoring cellular homeostasis under pH-induced stress. Photosynthetic rates generally correlated …

Collaborative Care Intervention For Individuals With Severe Mental Illness: The Partners2 Programme Including Complex Intervention Development And Cluster Rct, Humera Plappert, Richard Byng, Siobhan Theresa Reilly, Charley Hobson-Merrett, Jon Allard, Elina Baker, Nicky Britten, Melanie Calvert, Michael Clark, Siobhan Creanor, Linda Davies, Rebecca Denyer, Julia Frost, Linda Gask, Bliss Gibbons, John Gibson, Laura Gill, Ruth Gwernan-Jones, Joanne Hosking, Peter Huxley, Alison Jeffery, Benjamin Jones, Tom Keeley, Richard Laugharne, Steven Marwaha, Claire Planner, Tim Rawcliffe, Ameeta Retzer, Debra Richards, Ruth Sayers

Peninsula Medical School

Background and aims: Individuals living with severe mental illness such as schizophrenia and bipolar can have significant emotional, cognitive, physical and social challenges. Most people with severe mental illness in the United Kingdom do not receive specialist mental health care. Collaborative care is a system of support that combines clinical and organisational components to provide integrated and person-centred care. It has not been tested for severe mental illness in the United Kingdom. We aimed to develop and evaluate a primary care-based collaborative care model (PARTNERS) designed to improve quality of life for people with diagnoses of schizophrenia, bipolar or other …

The Role Of Data Sharing In Transboundary Waterways: The Case Of The Helmand River Basin, Najibullah Loodin, Gabriel Eckstein, Vijay P. Singh, Rosario Sanchez

Faculty Scholarship

While data and information exchanges theoretically play an effective role in the decision-making process of a shared watercourse, in practice, there are several challenges that prevent riparians from sharing data in an effective and cooperative manner. This chapter seeks to assess why the riparian nations of the Helmand River have failed to adopt an effective data exchange mechanism although both nations signed an internationally recognized bilateral water treaty in 1973. Applying a mixed study approach, the study draws on the theory of planned behavior (TPB) to interpret the main obstacles of data sharing between Afghanistan, the upstream state, and Iran, …

Causal Neuro-Symbolic Ai: A Synergy Between Causality And Neuro-Symbolic Methods, Utkarshani Jaimini, Cory Henson, Amit Sheth

Publications

Causal Neuro-Symbolic AI combines the benefits of causality with Neuro-Symbolic Artificial Intelligence (NeSyAI). More specifically, it (1) enriches NeSyAI systems with explicit representations of causality, (2) integrates causal knowledge with domain knowledge, and (3) enables the use of NeSyAI techniques for causal AI tasks. The explicit causal representation yields insights that predictive models may fail to analyze from observational data. It can also assist people in decision-making scenarios where discerning the cause of an outcome is necessary to choose among various interventions.

Language Change At The Intersections Of Movement, Economy, And Orientation, Joseph A. Stanley, Margaret E. L. Renwick, Monica Nesbitt

Faculty Publications

A growing amount of research on North American English varieties shows that many sociolinguistic variables peaked among the Baby Boomer Generation (born approximately 1946–64). By “peak,” we mean that a linguistic phenomenon in one community has reached its point of greatest intensity and is maximally divergent from realizations of that same variable in most other North American communities. Similarly, we also find studies that describe a “cliff” beginning among Generation X (born approximately 1965–82) such that after generations of relative stability, local dialect features are lost. Nesbitt (2021, 359) observes that “the Baby Boomer–Gen X transition appears to be a …

2024 Spring Commencement, Georgia Southern University

Commencement Programs

No abstract provided.

The Australian Frailty Network: Development Of A Consumer-Focussed National Response To Frailty, Natasha Reid, Adrienne Young, Loretta Baldassar, Anja Christoffersen, Tracy Comans, Simon Conroy, Christopher Etherton-Beer, Jason Ferris, Maria Fiatarone Singh, Sarah Fox, Emily H. Gordon, Manonita Ghosh, Chandana Guha, Sarah Hilmer, Lisa Kouladjian O’Donnell, Benignus Logan, Kristiana Ludlow, Michelle Miller, Mark Morgan, Alison Mudge, John Muscedere, Donna Reidlinger, Kenneth Rockwood, Rosemary Saunders, David Ward, Paul Yates

Research outputs 2022 to 2026

Frailty is an important concept in the care of older adults. Over the past two decades, significant advances have been made in measuring frailty. While it is now well-recognised that frailty status is an important determinant of outcomes from medical illnesses or surgical interventions, frailty measurement is not currently routinely integrated into clinical practice. In the community setting, it is uncommon for general practitioners to deliver frailty-optimised care. In hospitals, there is substantial variability in how people living with frailty are managed. This variability is notable between and even within disciplines. Furthermore, gains from understanding frailty mechanisms and risk factors …

Eagle Executive Magazine, Georgia Southern University

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Wipo Negotiations On Intellectual Property, Genetic Resources And Associated Traditional Knowledge, Peter K. Yu

Faculty Scholarship

At the 2000 General Assembly, the World Intellectual Property Organization (WIPO) established the Intergovernmental Committee on Intellectual Property and Genetic Resources, Traditional Knowledge and Folklore (IGC) to address intellectual property issues relating to genetic resources, traditional knowledge (TK) and traditional cultural expressions (TCEs). Although the IGC initially focused its work on studying these issues, it obtained a new mandate to accelerate its work in October 2009 and began text-based negotiations on an international instrument, or international instruments, a few months later. These negotiations paved the way for WIPO to convene a diplomatic conference to conclude an International Legal Instrument Relating …