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Bayesian Rare Variant Analysis Identifies Novel Schizophrenia Putative Risk Genes, Shengtong Han

School of Dentistry Faculty Research and Publications

The genetics of schizophrenia is so complex that it involves both common variants and rare variants. Rare variant association studies of schizophrenia are challenging because statistical methods for rare variant analysis are under-powered due to the rarity of rare variants. The recent Schizophrenia Exome meta-analysis (SCHEMA) consortium, the largest consortium in this field to date, has successfully identified 10 schizophrenia risk genes from ultra-rare variants by burden test, while more risk genes remain to be discovered by more powerful rare variant association test methods. In this study, we use a recently developed Bayesian rare variant association method that is powerful …

Preservice Eal/D Teachers’ Relational Agency During Online Paired Practicum, Hongzhi Yang, Andrew Ross

Australian Journal of Teacher Education

There is scant research on preservice English as an additional language or dialect (EAL/D) teachers’ paired practicums in an online context. Underpinned by Cultural Historical Activity Theory, this paper explores how preservice EAL/D teachers exercise their relational agency during online paired practicums. Data were collected from five preservice EAL/D teachers’ weekly journals written during their paired practicums and interviews after they completed their paired practicums. Following the key components of relational agency, the thematic analysis highlights the dialectical relationship between preservice teachers’ relational agency and different types of collaboration, evidenced by the formation of mutual objects, tool mediation, and shared …

Pathophysiology Of Pain And Mechanisms Of Neuromodulation: A Narrative Review (A Neuron Project)., Marcin Karcz, Alaa Abd-Elsayed, Krishnan Chakravarthy, Mansoor M Aman, Natalie Strand, Mark N Malinowski, Usman Latif, David Dickerson, Tolga Suvar, Timothy Lubenow, Evan Peskin, Ryan D'Souza, Eric Cornidez, Andrew Dudas, Christopher Lam, Michael Farrell Ii, Geum Yeon Sim, Mohamad Sebai, Rosa Garcia, Lucas Bracero, Yussr Ibrahim, Syed Jafar Mahmood, Marco Lawandy, Daniel Jimenez, Leili Shahgholi, Kamil Sochacki, Mohamed Ehab Ramadan, Vinicius Tieppo Francio, Dawood Sayed, Timothy Deer

Neuroscience Articles

Pain serves as a vital innate defense mechanism that can significantly impact an individual's quality of life. Understanding the physiological effects of pain well plays an important role in developing novel pain treatments. Nociceptor neurons play a key role in pain and inflammation. Interactions between nociceptors and the immune system occur both at the site of injury and within the central nervous system. Modulating chemical mediators and nociceptor activity offers promising new approaches to pain management. Essentially, the sensory nervous system is essential for modulating the body's protective response, making it critical to understand these interactions to discover new pain …

The Complexities Of Disproportionality In A Large Urban School District: A Look Into District Interventions And Identification Processes, Linnie Tennile Tarrant

Dissertations of Practice

This study delves into the implementation of the multi-tiered system of supports (MTSS) and the special education identification process in a large urban school district in Illinois, with a specific focus on disproportionality in special education referrals. The district has been identified as disproportionate in categorizing African American students under the emotional disturbance (ED) category since 2014. Using a grounded theory approach, interviews were conducted with ten building-level administrators to investigate the consistency of MTSS implementation and the process of identifying students for special education services. Data was collected through in-depth interviews, and themes were analyzed using open, axial, and …

Using A Degree-Based Network Model To Understand And Control Traffic Jams In The Atlanta Metropolitan Area, Ian Salamone-Lent, Theresa Washington, Asma Azizi

The Kennesaw Journal of Undergraduate Research

Traffic congestion is an enduring problem for major metropolitan areas, such as Atlanta, GA. Our goal is to understand the nature of traffic congestion patterns in the highway system of Cobb County in Atlanta, GA. We created a road network representative of the Cobb County highway system and then superimposed a degree-based SIR model to simulate traffic congestion on that network. The model’s parameters, propagation and dissipation rates, were estimated using empirical traffic data, which are vehicles’ speed time series and speed limit of each road in the network. We then conducted a local sensitivity analysis of the model’s key …

From Mind To Matter: Patterns Of Innovation In The Archaeological Record And The Ecology Of Social Learning, Kathryn Demps, Nicole M. Herzog, Matt Clark

Anthropology Faculty Publications and Presentations

Archaeology and cultural evolution theory both predict that environmental variation and population size drive the likelihood of inventions (via individual learning) and their conversion to population-wide innovations (via social uptake). We use the case study of the adoption of the bow and arrow in the Great Basin to infer how patterns of cultural variation, invention, and innovation affect investment in new technologies over time and the conditions under which we could predict cultural innovation to occur. Using an agent-based simulation to investigate the conditions that manifest in the innovation of technology, we find the following: (1) increasing ecological variation results …

Pharmacology Of Veratrum Californicum Alkaloids As Hedgehog Pathway Antagonists, Madison L. Dirks, Owen M. Mcdougal

Chemistry and Biochemistry Faculty Publications and Presentations

Veratrum californicum contains steroidal alkaloids that function as inhibitors of hedgehog (Hh) signaling, a pathway involved in the growth and differentiation of cells and normal tissue development. This same Hh pathway is abnormally active for cell proliferation in more than 20 types of cancer. In this current study, alkaloids have been extracted from the root and rhizome of V. californicum, followed by their separation into five fractions using high performance liquid chromatography. Mass spectrometry was used to identify the presence of twenty-five alkaloids, nine more than are commonly cited in literature reports, and the Bruker Compass Data Analysis software …

Utilizing A Structured Music Therapy Program For Adolescents With Anxiety And Depression, Amy Haagen

West Chester University Doctoral Projects

Anxiety and depression are two of the most common mental health issues that affect children and adolescents. It has been noted that twenty percent of adolescents will have a depressive episode or be affected by anxiety by the time they are 18 years old. Mental health issues affecting children and adolescents majorly impact all aspects of their lives, most notably academic success, behavior, growth, and development (Porter et al., 2017). Current treatments for mental disorders, including depression and anxiety, include pharmacological and psychotherapeutic treatments. In the adolescent population, there are conflicting opinions on the use of antidepressants due to risks …

Network Pharmacology And Molecular Docking Reveals The Therapeutic Mechanism Of Musa Acuminata Against Obsessive-Compulsive Disorder, Hasan Ansari, Prekshi Garg, K. S. Rashmi, Grisilda Vidya Bernhardt

Open Access archive

Network pharmacology integrates systems biology and bioinformatics to explore the intricate relationships among drugs, targets, diseases, and other molecular docking used to explore the effect of Musa acuminata against obsessive-compulsive disorder (OCD). OCD is a behavioral and mental neurological condition. The occurrence of patients with OCD has increased in recent times due to both genetic and environmental factors. Genetic factors involve variations in certain genes that give instructions for proteins that react to or transport the neurotransmitter known as serotonin which has been associated with an increased risk of OCD. Thus, the present study aims to establish the therapeutic properties …

Multicentric Osteolysis Nodulosis And Arthropathy (Mona): A Case Series And Review Of The Literature, Mahabaleshwar Mamadapur, Sabarinath Mahadevan, Ponniah Subramanian Arulrajamurugan, Srilakshmi Gandham

Open Access archive

Multicentric Osteolysis Nodulosis and Arthropathy (MONA) is a rare skeletal disorder driven by mutations in the MMP2 gene, leading to bone and joint degradation. This case series presents three unique MONA cases, highlighting clinical, radiological, and genetic aspects. These insights shed light on the complexities of MONA, aiding early diagnosis and multidisciplinary management. Case 1 is a 13-year-old male, born to consanguineous parents, presented with a 5-year history of progressive joint deformities, pain, and difficulty walking. Initially diagnosed as juvenile idiopathic arthritis (JIA), despite treatment, his symptoms persisted. Examination revealed multiple clinical findings, including joint contractures and nodules. Genetic analysis …

Navigating The Complexity Of Braf Mutations In Non-Small Cell Lung Cancer: Current Insights And Future Prospects, Sufyan Ibrahim, Smita Shenoy, Ramya Kateel, Shreya Hegde

Open Access archive

There are many challenges that are faced in the treatment of Non-Small Cell Lung Cancer (NSCLC) due to the complexities associated with the tumor. Association of different types of mutations are one of the major complexities. Among these mutations, BRAF mutations are significantly gathering more attention due to their impact on disease progression and therapeutic response. This review provides an analysis of the current understanding of BRAF mutations in NSCLC, focusing on the molecular intricacies, clinical implications, and therapeutic advancements. The article explores the diverse spectrum of BRAF mutations, highlighting the prevalence of specific mutations such as V600E and non-V600E …

Correlation Of Patient Characteristics With Peak Enhancement Time For Pediatric Cardiac Computed Tomography In Congenital Heart Disease, T. Visakh, P. S. Priya, Nitika C. Panakkal, Gunjan Banga

Open Access archive

Objectives: Cardiac computed tomography (CCT) plays a key role in diagnosing congenital heart disease (CHD), emphasizing the need for specialized protocols in newborns due to CHD’s complexity. The aim is to explore the relationship between peak enhancement time (PET) and various parameters during CHD assessment with CCT. Material and Methods: The study involved 38 CHD patients undergoing CCT, with observations made on their heart rate, respiratory rate, saturation, cardiac output, weight, height, and age. The PET for each case was determined, and Spearman’s rank correlation was employed to evaluate the association between these parameters and the PET. Results: The median …

Demystifying Multiple Sclerosis Diagnosis Using Interpretable And Understandable Artificial Intelligence, Krishnaraj Chadaga, Varada Vivek Khanna, Srikanth Prabhu, Niranjana Sampathila

Open Access archive

Multiple sclerosis (MS) is a dangerous illness that strikes the central nervous system. The body's immune system attacks myelin (an entity above the nerves) and impairs brain-to-body communication. To date, it is not possible to cure MS. However, symptoms can be managed, and treatments can be provided if the disease is diagnosed early. Hence, supervised machine learning (ML) algorithms and several hyperparameter tuning techniques, including Bayesian optimization, have been utilized in this study to predict MS in patients. Descriptive and inferential statistical analysis has been conducted before training the classifiers. The most essential markers were chosen using a technique called …

A Brief Exploration Of Artificial Intelligence In Dental Healthcare: A Narrative Review, Prakrati Kamath, Prathvi Kamath, Sharon J.R. Saldanha, Thilak B. Shetty

Open Access archive

Artificial intelligence is a computer system which can replicate human behavior and largely supports human actions and interpretation, but not replace human responses. Over the past few decades, the field of artificial intelligence (AI) has experienced phenomenal development and expansion. We are surrounded by several instances of AI. AI has applications in different branches of Dentistry. A total of 59 papers from an electronic search using Google Scholar and PubMed were used to create this narrative review. Artificial intelligence can be utilised for diagnosis, decision-making, treatment planning, early detection and prevention of oral disease, and finally result prediction by utilising …

Simulation Study And Reliability Analysis Of Low Actuation Voltage Cantilever Based Rf Mems Switch, Shivashankar A. Huddar, B. G. Sheeparmatti, A. Y. Patil, Nalini C. Iyer

Open Access archive

This paper reemphasizes the importance of material consideration to design a low pull-in voltage MEMS switch. We have simulated different variants of a cantilever-based MEMS switch with variations in length, thickness, and material of the cantilever beam. The simulation study provides an understanding of a suitable cantilever design to achieve low operating voltage MEMS switch. We have further simulated the mechanical properties of these designs of the cantilever beam for a low operating voltage by computing the equivalent electrostatic force which is the input to the mechanical simulations performed using ANSYS. The electromechanical simulation provided similar trends of deflection and …

Analysis Of The Magnetohydrodynamic Effects On Non-Newtonian Fluid Flow In An Inclined Non-Uniform Channel Under Long-Wavelength, Low-Reynolds Number Conditions, Manjunatha Gudekote, Rajashekhar Choudhari, Prathiksha Sanil, Hanumesh Vaidya

Open Access archive

This study utilises mathematical modelling and computations to analyse the magnetohydrodynamic (MHD) effects on non-Newtonian Eyring-Powell fluid flow in an inclined non-uniform channel under long-wavelength, low Reynolds number conditions. The governing equations are solved by applying slip boundary conditions to determine the velocity, temperature, concentration, and streamline profiles. The key findings show that the magnetic parameter dampens the flow rate. The relationship between the variable viscosity, velocity, and temperature is nonlinear. The wall rigidity parameter and axial velocity are directly proportional until a threshold. Increasing inclination angles distorts streamlines. The magnetic field alters concentration contours and thermal transport. MATLAB parametric …

Osseointegrative And Antimicrobial Properties Of Graphene Oxide Nano Coated Dental Implants: A Systematic Review, Sounyala Rayannavar, Sunil Kumar Mv, Vignesh Kamath, Mahantesh Bembalgi

Open Access archive

Introduction: Osseointegration stands as a pivotal concept within the realm of dental implants, signifying the intricate process through which a dental implant integrates with the adjoining bone tissue. Graphene oxide (GO) has been shown to promote osseointegration, the process by which the implant fuses with the surrounding bone. The objective of this study was to assess the osseointegrative and antimicrobial properties of GO nano coated dental implants. Methods: A systematic search was conducted using electronic databases (e.g., PubMed, Scopus, Web of Science) to identify relevant studies published. Inclusion criteria encompassed studies that evaluated the effects of GO nano coating on …

Assessing The Effectiveness Of Moscow Prioritization In Software Development: A Holistic Analysis Across Methodologies, Suchetha Vijayakumar, Prasad K. Krishna, Holla M. Raviraja

Open Access archive

Effective software Requirement Prioritization plays a pivotal role in the success of the Software Development process, ultimately contributing to the successful delivery of high-quality products. Among the various methods for Requirement Prioritization, the MoSCoW method has gained widespread adoption due to its ease of use. However, its overall effectiveness remains a subject of inquiry. This paper presents a rigorous assessment of the MoSCoW Requirement Prioritization technique, drawing insights from software developers who engage in the Prioritization process. Our evaluation encompasses a distinct perspective: that of the developers tasked with Prioritization. The feedback solicited from developers encapsulates a diverse set of …

Lb-Sam: Local Beam Search With Simulated Annealing For Community Detection In Large-Scale Social Networks, Keshab Nath, Rupam Kumar Sharma, S. K. Mahmudul Hassan

Open Access archive

With the rapid development of internet technologies and the increasing availability of large-scale data, the detection of community structures within complex networks has become a critical area of research. This paper introduces a novel community detection technique called LB-SAM (Local Beam Search with Simulated Annealing and Modularity), designed to efficiently uncover hidden community structures in large-scale social networks. LB-SAM integrates Local Beam Search (LBS) to explore the local network structure and Simulated Annealing (SA) to globally optimize modularity, enabling the detection of communities with intricate boundaries and strong internal connections. By focusing on influential nodes to form subgroups and recursively …

Efficacy Of Lycium Barbarum (Goji Berry) Mouthwash For Managing Periodontitis: A Randomized Clinical Trial, Amee Sanghavi, Laasya Shettigar, Aditi Chopra, Ashmeet Shah

Open Access archive

Background: Removal of the microbial deposits (plaque and calculus) by performing effective scaling and root planing (SRP) is the fundamental step for managing periodontal disease (gingivitis and periodontitis). Various adjuncts in the form of mouthwash, gels, and toothpaste are also being used as adjuncts to SRP for managing periodontitis. Recently, Lycium barbarum (L. barbarum), commonly known as goji berry or wolfberry, has gained popularity for managing chronic inflammatory and infectious diseases. However, its efficacy in managing periodontitis has never been explored. Hence the present study aims to evaluate the efficacy of goji berry mouthwash compared to chlorhexidine mouthwash for managing …

Stories Of Dismantling Whiteness In Social Work Educational Spaces, Jeanean Mohr

West Chester University Doctoral Projects

Social work and higher education are rooted in systems of racism and exclusion and continue to operate as racialized spaces. As the social work profession grapples with its past and calls upon social work educators to support efforts to undo structural racism, paying attention to what is happening in educational spaces is essential. In this study, I examined the stories and tensions of White Social Work faculty engaged in efforts to dismantle whiteness in their classrooms, departments, and universities. Using narrative inquiry, I interviewed nine White faculty from different universities representing five regions across the United States. I explored their …

Classrooms, Hallways, And Peleas: The Violence And The Education Of Latino Students, Pamela Margolis

West Chester University Doctoral Projects

Latino children attend schools that are informed by violent, biased, and racist beliefs that make it difficult for them to attain educational success. Informed by Latino Critical Race Theory (LatCrit) this qualitative study examined the narratives and lived experiences of bilingual Latino children and their families and the educational violence they were subjected to in schooling. The research team completed 8 semi structured family interviews equaling twenty-five people with 12 parents and 13 children. Children ranged in age from 8 to 17 years old. Methodologies included family interviews in which most of the parents’ interviews were conducted in Spanish and …

Concepts In Animal Parasitology, Chapter 39: Haplosplanchnata Olson Et Al., 2003 (Suborder): Two Hosts With Half The Guts [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Daniel C. Huston

Concepts in Animal Parasitology

An overview of the suborder Haplosplanchnata Olson et al., 2003, a small, but distinct lineage within the Plagiorchiida. Includes a discussion of the methods of identification, general morphological characteristics, taxonomy, and life cycles.

Chapter 39 in Concepts in Animal Parasitology, by Daniel C. Huston. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap039

Concepts In Animal Parasitology, Chapter 47: Summary Of The Digenea (Subclass): Insights And Lessons From A Prominent Parasitologist [Platyhelminthes, Trematoda, Digenea], Robin M. Overstreet

Concepts in Animal Parasitology

An overview of the digenean trematodes (subclass Digenea) including insights and lessons from a prominent parasitologist, Robin M. Overstreet. Includes discussion of general morphology, biology, preparation methods, phylogeny, classification, life cycles, host-digenean relationships, effects on host behavior, hyperparasitism, ecology, digeneans as indicators, and literature on the digeneans.

Chapter 47 in Concepts in Animal Parasitology, by Robin M. Overstreet. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap047

Concepts In Animal Parasitology, Chapter 60: Monogenea Van Beneden, 1858 (Class) [Platyhelminthes], Griselda Pulido-Flores

Concepts in Animal Parasitology

An overview of the class Monogenea van Beneden, 1858, mainly ectoparasites of the skin, fins, gills, and urinary bladder of fishes, amphibians, and some reptiles. Includes discussion of their classification (both historical and current), general morphology, life cycles, and taxonomy.

Chapter 60 in Concepts in Animal Parasitology, by Griselda Pulido-Flores. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap060

Concepts In Animal Parasitology, Chapter 64: Phthiraptera (Order): Lice [Arthropoda], Lajos Rózsa, Haylee J. Weaver

Concepts in Animal Parasitology

An overview of lice, order Phthiraptera, including discussion of their general morphology, feeding, host range, host distribution, life cycle, macroecology, transmission, effects on hosts and role as vectors, host defenses, conservation, evolutionary origins, phylogeny, lice nuclear genome, taxonomy, and medical implications including their control.

Chapter 64 in Concepts in Animal Parasitology, by Lajos Rózsa and Haylee J. Weaver. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap064

Use Of Otolith Microchemistry To Determine Natal Origins For Silver Carp Hypophthalmichthys Molitrix In The Lower Mississippi River Basin, C. Barshinger, M. Eggleton, J. Spurgeon

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

No abstract provided.

Comparison Of Two Otolith Processing Methods For Silver Carp Age Estimation, J. N. Stevens, C. E. Barshinger, J. J. Spurgeon, M. A. Eggleton, S. E. Lochmann

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

No abstract provided.

Building And Fostering Honors Communities: Lessons From Social Distancing, Anne Dotter, Kathleen King

National Collegiate Honors Council Monographs: Chapters

While scholars of online education have been developing ways to foster a sense of belonging in online spaces for years, many of us in honors were thrown into the deep end for the first time in March 2020. As a result, we are now able to see the potential of online practices in a way we could not previously. This chapter tells the story of how we came to see the value of virtual community made possible by digital technology as an invaluable complement to the in-person work of a twenty-first-century honors program. Before the Work from Home (WFH) era, …

Udl As A Framework For Expanding Liaison Work And Engaging With Students, Erica Defrain

University of Nebraska-Lincoln Libraries: Faculty Publications

This chapter examines the development of a series of virtual workshops designed to strengthen research and information strategies in the social sciences. Guided by the principles of Universal Design for Learning (UDL)—emphasizing equity, flexibility, and simplicity—the program evolved into both a successful synchronous learning experience and a sustainable suite of asynchronous instructional objects accessible across the university. Now in its third semester, the workshops have expanded beyond traditional liaison boundaries, increasing awareness of library resources and services throughout the academic community. The chapter details the iterative process of developing, designing, and assessing the workshops through a UDL framework, highlighting pedagogical …