Digital Commons Network^™

Dreams As Inspiration For Music Composition In American And European Musicians, Kai Parlett

Spectrum

No abstract provided.

Gestational Weight Gain And Epilepsy In The Offspring: A Population-Based Retrospective Cohort Study, Jiawen Chen

Public Health Theses

AbstractBackground and aims: Epilepsy is one of the most common neurologic disorders in childhood, but the etiology for the majority of the cases remains unknown. As a modifiable trait in pregnancy, gestational weight gain (GWG) has been shown to be a risk factor for multiple adverse birth outcomes. This study aims to investigate whether non-optimal GWG is associated with the risk of epilepsy in the offspring using a linked database in California. Methods: A population-based cohort study was conducted using the linked database from the Birth Certificate Record in California (2007-2015) for GWG, and the diagnostic records of epilepsy from …

Development And Optimization Of A Novel Eeev Microsphere Immunoassay: Using Xeno-Surveillance Methodology To Characterize Avian Herd Immunity, Kaitlyn Gabriele Maurais

Public Health Theses

Introduction: Eastern equine encephalitis virus (EEEV), a mosquito-borne alphavirus, is detected throughout the eastern United States. The primary enzootic vector, Culiseta melanura (Blacktailed mosquito), allows transmission among 50+ avian host species resulting in complex disease patterns. Spillover to dead-end host mammals, such as equines and humans, rarely occurs, however, human cases can cause severe neurological deficits and have a 30% mortality rate. Eco-epidemiology and avian host immunity patterns are not well characterized for EEEV and require ongoing surveillance to develop more targeted interventions. Methods: Xeno-surveillance is an approach to survey EEEV through hematophagous arthropods, instead of collecting samples from a …

Evaluating The Susceptibility Of The Lew.1wr1 Rat To Glucose Intolerance, Insulin Resistance, And Masld : Is Fat10 The Key?, Quiana Claudette Wilkerson Vidal

Dissertations

Obesity is an epidemic that affects over 40% of adults in America. Obesity can be divided into metabolically healthy and metabolically unhealthy obesity, with the latter being characterized by symptoms closely associated with metabolic syndrome, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD). What causes the transition from metabolically healthy to metabolically unhealthy obesity is not fully known. Further, it is unclear how this transition correlates with the onset of co-morbid conditions. We propose that Ubiquitin D (FAT10) may play a role in transitioning into a metabolically unhealthy state in response to obesity. This dissertation evaluated two main …

Impacts Of Anthropogenic Sedimentation On Shell-Bed Habitats In Lake Tanganyika, Africa, Michael Soreghan, Andrew Cohen, Michael M. Mcglue, Kevin M. Yeager, Emily Ryan, Alison Johns, Ishmael Kimirei

Earth and Environmental Sciences Faculty Publications

Lake Tanganyika, in central Africa, contains a diverse and endemic fauna under threat from global climate change, overfishing, and nearshore sediment pollution. Previous studies of sediment pollution focused justifiably on impacts along rocky shorelines where diversity is high, but Lake Tanganyika also contains widespread shelly accumulations (shell beds) unprecedented in the modern East African lakes, but where impacts are less con- strained. Here we integrate multiple datasets from three sites along the Tanzanian shoreline to explore how variation in sedimentation rates and sediment quality impacts shell-bed substrate and diversity and abundance of ostracodes and sponges across sites that exhibit varying …

The Effect Of The Learning To Breathe Mindfulness Program On Salivary Cortisol Stress Response, Diamond Williams

West Chester University Master’s Theses

College students are at risk of experiencing negative mental and physical health outcomes due to stress, inadequate coping skills and problems with emotion regulation. Mindfulness interventions could help with this because mindfulness has been shown to improve mental and physical health. The present study investigated the effects of a six-week mindfulness intervention (Learning to BREATHE) on the cortisol stress responses to a cognitive challenge task in college students. Salivary cortisol samples collected were analyzed to assess improvements from before to after the intervention in a group of introductory psychology students who participated in weekly in-person mindfulness training as compared to …

Itihas Vol. 24 Issue No. 1, Sastra Univ

ITIHAS

NEWSLETTER FROM SASTRA DEEMED UNIVERSITY

Periodontal Health In End-Stage Renal Disease Patients Undergoing Hemodialysis, Hosam Nagy, Wafaa Saleh, Ghada El Kannishy, Jilan Mohamed Youssef

Mansoura Journal of Dentistry

Aim of the study: The aim of this study is to evaluate periodontal health status of the hemodialysis (HD) patients and to examine the relation between Russel periodontal index (RPI) and laboratory and inflammatory markers and nutritional status in this group of patients.

Methods: A cross-sectional study was conducted on a group of patients (n=43, mean age 51.4±14.9 years) recruited from the Mansoura university Nephrology and Dialysis Unit (MNDU). Periodontal examination was performed using Russel periodontal index (RPI). Various laboratory and inflammatory markers were recorded, including routine biochemical and hematological data as well as serum parathyroid hormone, ferritin, and highly …

Omega Roll-Envelope Flap Versus Free Sub-Epithelial Connective Tissue Graft In Thin Periodontal Phenotype In Stage Ii Implant Surgery: Randomized Controlled Clinical Trial, Ahmed Hosney Fawzy, Mohamed Abdel Raheem Al Shahat, Mohamed Ellayeh, Eman M. Abdulhady

Mansoura Journal of Dentistry

Objective: The objective of this randomized clinical trial (RCT) was to analyze the clinical outcomes of labial gingival tissue augmentation throughout stage II implant surgery in subjects with thin gingival phenotype (GP) using the free sub-epithelial connective tissue graft (FSCTG) versus Omega roll envelop flap technique (OREF).

Subjects and Methods: Sixteen patients with thin GP (˂ 1.5 mm) got 20 implants in this 6—month follow up RCT and split into two groups. 1) Group I: 8 patients got 10 implants in stage I surgery and got OREF for labial soft tissue augmentation in stage II surgery. 2) Group II: 8 …

Clinical And Radiographical Assessment Of Platelet Rich Fibrin (Prf) Versus Placental Extract Gel On Delayed Implant Placement: Comparative Clinical Split Mouth Study, Eman Shawki Mira, Ayman Abdel Rahim Mohammed Elkashty, Ahmed Mohammed Saaduddin Sapri

Mansoura Journal of Dentistry

Purpose: This study was established to compare Platelet Rich Fibrin (PRF) versus Placental Extract Gel on delayed implant placement.

Patient and Methods: Sixteen patients aged from 35-45 years were selected for that study. Split mouth design was performed, placing PFR on one side of the mouth while placing placental extract gel on the other side of the mouth during implant insertion. Follow -up was done for all the cases 6 months postoperatively both clinically and radiographically. When comparing two groups within the same timepoint, the student unpaired t-test was employed, and when comparing two timepoints within the same group in …

Morphological Analysis Of Selected Verses From The Holy Quran, Huda Sa’D Dakhil Hadi

NJF Islamic University Journal

This research studies what morphology is, namely the study of word formation. It talks about the morpheme and the types of morphemes. It also considers the reasons why languages have morphemes. It also studies the importance of morphology, its function and rules. Furthermore, this study discovers the morphological analysis of the Quranic text that may help the non-Arab readers of the holy text. There could be more coming studies to reveal the rhetoric miracles of the Glorious Quran. The objective of this study is to help the reader understand the Quranic texts very clearly. Among the most important difficulties that …

Saving Ourselves From Infection: A Theraputic Model Of Peer Led Education, Jessica Tkacs Way

West Chester University Master’s Theses

The purpose of this action research is to explore non-hierarchical peer led education as a means to end the Hepatitis C epidemic, promote empowerment and self-esteem in current injection drug users, and create a more global understanding of power structures that perpetuate opioid use so that those living with addiction are better able to educate, organize and fight for structural change. The current healthcare system is not able to test, treat or educate those most at risk for Hepatitis C infection or reinfection - people who inject drugs. The United States is currently in a losing battle with opioid addiction, …

The Loss Of Βι Spectrin Alters Synaptic Size And Composition In The, Michael C Stankewich, Luanne L. Peters, Jon S Morrow

Faculty Research 2024

Introduction: Deletion or mutation of members of the spectrin gene family contributes to many neurologic and neuropsychiatric disorders. While each spectrinopathy may generate distinct neuropathology, the study of βΙ spectrin’s role (Sptb) in the brain has been hampered by the hematologic consequences of its loss.

Methods: Jaundiced mice (ja/ja) that lack βΙ spectrin suffer a rapidly fatal hemolytic anemia. We have used exchange transfusion of newborn ja/ja mice to blunt their hemolytic pathology, enabling an examination of βΙ spectrin deficiency in the mature mouse brain by ultrastructural and biochemical analysis.

Results: βΙ spectrin is widely utilized throughout the brain as …

New Directions For Alzheimer's Disease Research From The Jackson Laboratory Center For Alzheimer's And Dementia Research 2022 Workshop., Maria Telpoukhovskaia, Thomas J Murdy, Olivia J Marola, Kevin Charland, Michael Maclean, Tain Luquez, Alexandra M Lish, Sarah Neuner, Amy R Dunn, Kristen D. Onos, Jesse Wiley, Derek Archer, Matthew J Huentelman, Matthias Arnold, Vilas Menon, Alison Goate, Linda J Van Eldik, Paul R Territo, Gareth R Howell, Gregory W. Carter, Kristen M S O'Connell, Catherine Kaczorowski, The 2022 Jax Cadr Workshop

Faculty Research 2024

INTRODUCTION: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field.

METHODS: During the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus. Following the workshop, each group used standard literature search methods to provide background for each topic.

RESULTS: The team of invited experts identified four key areas that can be collectively addressed to make a significant impact in the field: (1) Prioritize the diversification …

Northeastern Illinois University, Academic Catalog 2024-2025, Northeastern Illinois University

Course Catalogs

No abstract provided.

Diurnal, Seasonal, And Vertical Changes In Photosynthetic Rates In Cinamomum Camphora Forests In Subtropical China, Zhiqiant Li, Qinxiang Wu, Yuanying Peng, Junjie Lei, Shuguang Liu, Can Mao, Xin Liu, Jun Wang, Wende Yan, Xiaoyong Chen

Faculty Authors and Creators Reception

The increase in the global atmospheric CO2 concentration is expected to increase the productivity of forests, but the dynamic processes of such increased productivity in the forest canopy remain unclear. In this study, diurnal and seasonal variations and vertical changes in photosynthetic rates were investigated in Camphor tree (Cinnamomum camphora) forests in subtropical China. The effect of photosynthetically active radiation (PAR) and CO2 concentrations on photosynthetic rates were also examined in the studied forests. Results showed the diurnal patterns of photosynthesis exhibited two peaks on sunny days, but only one peak on cloudy days. The daily average photosynthetic rate on …

Digitalization Of Toxicology: Improving Preclinical To Clinical Translation., Brian R Berridge, Szczepan W Baran, Vivek Kumar, Natalie Bratcher-Petersen, Michael Ellis, Chang-Ning Liu, Timothy L Robertson

Faculty Research 2024

Though the portfolio of medicines that are extending and improving the lives of patients continues to grow, drug discovery and development remains a challenging business on its best day. Safety liabilities are a significant contributor to development attrition where the costliest liabilities to both drug developers and patients emerge in late development or post-marketing. Animal studies are an important and influential contributor to the current drug discovery and development paradigm intending to provide evidence that a novel drug candidate can be used safely and effectively in human volunteers and patients. However, translational gaps-such as toxicity in patients not predicted by …

Phosphorus-Independent Role Of Fgf23 In Erythropoiesis And Iron Homeostasis., Min Young Park, Rafiou Agoro, Stanislovas S Jankauskas, Carole Le Henaff, Despina Sitara

Faculty Research 2024

A number of studies have reported an association between phosphorus, red blood cell (RBC) production, and iron metabolism. However, it is difficult to distinguish whether the effect of phosphorus is direct or through the actions of FGF23, and it is not clear whether phosphorus is positively or negatively associated with RBC production. In the present study, we investigated the effects of a) increased phosphorus load and b) phosphorus deficiency on erythropoiesis and iron metabolism in association with FGF23. Mice were fed either a 1.2% or 1.65% phosphorus diet and compared to mice fed a control diet containing 0.6% of phosphorus. …

Protecting Traditional Knowledge And Indigenous Peoples' Rights: The Key To Developing International Environmental Laws That Promote Harmonious Relationships With Nature, Melissa A. Padilla

California Western International Law Journal

No abstract provided.

Early Oligocene Record Of An “Iceberg Alley” In The Weddell Sea From Quartz Sand Microtextural Analysis At Odp Site 696, Victoria Hojnacki, Sandra Passchier

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

The greenhouse to icehouse transition at the Eocene-Oligocene boundary (34 Ma) marked the appearance of continental-scale glaciation in Antarctica. The material recovered from Ocean Drilling Program Site 696 is the only record spanning this major climatic shift in the Weddell Sea region. Using scanning electron microscopy, quartz microtextures in 13 samples across the Eocene-Oligocene transition were analyzed to understand the degree of glacial modification and the transportation history of the >150 µm material. The quartz grains were visually grouped, characterized, and interpreted by grain outline, relief, and surface microtextures. Glacial textures are present throughout the entire interval (34.4–33.2 Ma), with …

Applying Steve Jobs’S Insights On Innovation, Leadership, And Technology Toward An Apple-Inspired Law School, Byron G. Stier

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Mechanisms Of Action And Preservation Effects Of Packaging Systems For Mushrooms: Novel Approaches To Preserve Irish Edible Mushrooms, Tigist Tadesse Shonte, Mehraj Fatema Mulla, Lorraine Foley, Shivani Pathania

Articles

Mushrooms support the Irish economy, with a farm gate value of roughly EUR 130 million in 2022 and with 80%–85% of Irish production exported to the United Kingdom. In order to apply cutting edge technologies and offer creative solutions to increase the shelf life of mushrooms, it is essential to understand the mechanisms of action and preservation effects of the current trends in edible mushroom packaging systems. This review summarises the mechanisms of action for nanopackaging, biodegradable packaging, edible coatings, modified atmosphere packaging (MAP), and active packaging in terms of their enzyme activity, antimicrobial activity, antioxidant activity, and rate of …

Feasibility In Embedding Charismatic Leadership Strategies Into Social Work Applications, Lana Grinev

Student Publications

Purpose – The purpose of this paper is to determine whether charismatic leadership strategies can be successfully implemented within structures, systems and tasks for social workers to increase case management successes, particularly client well-being, given that the six key charismatic leadership traits align with presented professionally bound ethical expectations. Design/methodology/approach – A short generic qualitative review was done over fifteen publications, emphasizing the effects of charismatic leadership in domestic and foreign occupational domains. Findings – Methodological, thematic and theoretical analyses show that charismatic leadership strategies are active in relevant social work domains with positive participant impacts. Practical implications – The …

Nanoscale Interaction Of Endonuclease Ape1 With Dna, Sridhar Vemulapalli, Mohtadin Hashemi, Yingling Chen, Suravi Pramanik, Kishor Bhakat, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

Apurinic/apyrimidinic endonuclease 1 (APE1) is involved in DNA repair and transcriptional regulation mechanisms. This multifunctional activity of APE1 should be supported by specific structural properties of APE1 that have not yet been elucidated. Herein, we applied atomic force microscopy (AFM) to characterize the interactions of APE1 with DNA containing two well-separated G-rich segments. Complexes of APE1 with DNA containing G-rich segments were visualized, and analysis of the complexes revealed the affinity of APE1 to G-rich DNA sequences, and their yield was as high as 53%. Furthermore, APE1 is capable of binding two DNA segments leading to the formation of loops …

Coumarin-Based Aldo-Keto Reductase Family 1c (Akr1c) 2 And 3 Inhibitors, Sravan Jonnalagadda, Ling Duan, Louise F. Dow, Geetha P. Boligala, Elizabeth A. Kosmacek, Kristyn Mccoy, Rebecca E. Oberley-Deegan, Yashpal Singh Chhonker, Darryl J. Murry, C. Patrick Reynolds, Barry J. Maurer, Trevor M. Penning, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

A series of 7-substituted coumarin derivatives have been characterized as pan-aldo-keto reductase family 1C (AKR1C) inhibitors. The AKR1C family of enzymes are overexpressed in numerous cancers where they are involved in drug resistance development. 7-hydroxy coumarin ethyl esters and their corresponding amides have high potency for AKR1C3 and AKR1C2 inhibition. Coumarin amide 3 a possessed IC50 values of 50 nM and 90 nM for AKR1C3 and AKR1C2, respectively, and exhibits 'drug-like' metabolic stability and half-life in human and mouse liver microsomes and plasma. Compound 3 a was employed as a chemical tool to determine pan-AKR1C2/3 inhibition effects both as a …

Discovery Of An Aldo-Keto Reductase 1c3 (Akr1c3) Degrader, Angelica V. Carmona, Shirisha Jonnalagadda, Alfie M. Case, Krishnaiah Maddeboina, Sravan K. Jonnalagadda, Louise F. Dow, Ling Duan, Trevor M. Penning, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7) is the most common mutation of the AR receptor that confers resistance to clinical androgen receptor signalling inhibitors in castration-resistant prostate cancer. AKR1C3 interacts with ARv7 promoting stabilization. Herein we report the discovery of the first-in-class AKR1C3 Proteolysis-Targeting Chimera (PROTAC) degrader. This first-generation degrader potently reduced AKR1C3 expression in 22Rv1 prostate cancer cells with a half-maximal degradation concentration (DC₅₀) of 52 nM. Gratifyingly, concomitant degradation of ARv7 was …

N.U.R.T.U.R.E: Neutralizing Unsafe Risks Through Unique Responsive Environmental Care, Clara Durante, Easton Duppins, Feven Eskinder, Hiba Mohammed, Faith Niranoluwa

DC Health and Academic Prep Program (DC HAPP)

Environmental factors can be distinguished by physical, chemical, biological, behavioral, and socioeconomic categories. Each category has its own individual effect on human health. These environmental factors play a critical role in determining the health outcomes of pregnancies, influencing both maternal and fetal well-being. This project aims to empower pregnant women by providing comprehensive support and education on mitigating environmental risks. Environmental factors have a significant impact on pregnancy outcomes, specifically among women from lower socioeconomic status (SES) background. Low SES is linked with increased exposure to harmful environmental toxins, high stress levels, limited access to healthcare, which contribute to pregnancy …

Research Priorities For Childhood Apraxia Of Speech: A Long View, Patricia Mccabe, Molly Beiting, Elaine R. Hitchcock, Edwin Maas, Amy Meredith, Angela T. Morgan, Nancy L. Potter, Jonathan L. Preston, Laura Moorer, Pooja Aggarwal, Kirrie Ballard, Laura Baskall Smith, Nicole F. Caballero, Kathryn Cabbage, Julie Case, Susan Caspari, Karen V. Chenausky, Shina Cook, Ewa Grzelak, Maryane Gomez, Aubrie Hagopian, Chantelle Highman, Anne Hodits, Jenya Iuzzini-Seigel, Jillian Levos-Carlson, Barbara A. Lewis, Patricia Mayro, Jyutika Mehta, Gabrielle Miller, Kimberly D. Mory, Elizabeth Murray, Megan S. Overby

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

This article introduces the Journal of Speech, Language, and Hearing Research Special Issue: Selected Papers From the 2022 Apraxia Kids Research Symposium. The field of childhood apraxia of speech (CAS) has developed significantly in the past 15 years, with key improvements in understanding of basic biology including genetics, neuroscience, and computational modelling; development of diagnostic tools and methods; diversity of evidence-based interventions with increasingly rigorous experimental designs; and understanding of impacts beyond impairmentlevel measures. Papers in this special issue not only review and synthesize the some of the substantial progress to date but also present novel findings addressing critical research …

Effect Of Walleye Fry Stocking On Future Gillnet Cpue, Alexander Barker

Journal of Earth and Life Science

Walleye Sanders vitreus for many states, is a key attractant of anglers from around North America. Due to immense popularity, management efforts have been conducted to maintain Walleye populations, especially in the form of stocking. The purpose of this study is to analyze the effect of Walleye fry stocking on gillnet catch per unit effort (CPUE). A total of 90 lakes were analyzed for this study within three defined regions of Minnesota, 30 from each region. The regions chosen for this study are the Minnesota Department of Natural Resources northern pike Esox lucius regulation regions which consist of the Southern, …

Scoping Review: Health Care Use In Foster Care Children, Karen Mcwaters

Post-Professional Occupational Therapy Doctorate - Innovations in OT Symposium: Transforming Possibilities into Practice

No abstract provided.