Digital Commons Network^™

Policy Outcomes Of Culturally Integrated Health Care For African Americans, Victoria Aderin

Walden Dissertations and Doctoral Studies

Despite advancements in integrated care, persistent health care disparities and systemic barriers continue to contribute to poor health outcomes among African Americans. The purpose of this qualitative study was to explore the implementation of culturally integrated behavioral health care within the context of African American experiences, focusing on health care access and quality through a public policy lens. The study was informed by Ostrom's institutional analysis and development framework, health equity framework developed by the nonprofit organization Education Training & Research, and Hankivisky's intersectionality-based policy analysis. To gather data, semistructured interviews were conducted with 20 African American adults who receive …

Biodegradable Polymeric Microspheres For Magnetically Guided Drug Delivery To Tumors, Tyler Payson Green

Theses and Dissertations

This thesis investigates the feasibility of utilizing biodegradable polymeric microspheres loaded with the anticancer drug 5-fluorouracil (5FU) and superparamagnetic iron oxide nanoparticles (SPIONs) to magnetically deliver the cancer therapeutic 5FU to a target tumor in the human body. The primary method of material loading consisted of a w/o/w double emulsion mechanism which 1) loads and protects 5FU in the inner water phase consisting of distilled water and polyvinyl alcohol (PVA), 2) dispersed SPIONs in the biodegradable polymeric organic phase consisting of methylene chloride (MeCl2) for eventual magnetic transport, and 3) suspended these w/o emulsion droplets in an outer aqueous phase …

Arbuscular Mycorrhizal Fungi’S Effect On Lemon Balm Growth, Alissia D. Fulton, Oliver M. Banks, Tatum P. Fortney, Darlene Panvini Phd

Science University Research Symposium (SURS)

As used by Indigenous tribes throughout the Great Plains, lemon balm (Melissa officinalis) can be used for herbal remedies, ritualistic ceremonies, and culinary dishes. Studies show arbuscular mycorrhizal fungi improve nutrient uptake, stress tolerance, root growth, and disease resistance in their symbiotic plant relationships. From September to November 2024, 12 lemon balm plants were planted on the green roof at Belmont University. Half of them were treated with arbuscular mycorrhizal fungi; half of them were a control group. The control group grew more leaves than the fungi group. However, the fungi group grew taller than the control group. The inoculation …

Red Snapper Neurocranium, Roman Devlin, Michael A. Birnbaum, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Conquer And Prevail Issue 175 November 7 2024, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

Education Policy Committee Agenda November 07, 2024, Utah State University

Educational Policies Committee

• Approval of Minutes
• Subcommittee Reports
• Other Business
• Adjourn

Curriculum Subcommittee Agenda November 7, 2024, Utah State University

Educational Policies Committee

• Approval of Minutes
• Program Proposals
• Semester Course Approval Reviews
• Other Business
• Adjourn: 3:30pm

Boosting The Power Performance Of Microbial Fuel Cells By Using Dual Nanomaterial-Modified Carbon Felt Electrodes, Krishna Thapa, Wenyan Liu, Yuwei Zhang, David J. Westenberg, Yishu Zhou, Risheng Wang

Chemistry Faculty Research & Creative Works

Innovative design enhancements to microbial fuel cells (MFCs) are pivotal for improving their viability as renewable energy sources. This study introduces a dual approach to electrode modification, integrating polyaniline (PANI) and gold nanoparticles (AuNPs) on carbon felt (CF) anodes coupled with a unique cathode composed of DNA origami and chitosan. The synergistic effect of PANI and AuNPs significantly increases the hydrophilicity and conductivity of the anode, leading to a considerable surge in power density. Concurrently, the biocompatible DNA origami and chitosan-functionalized cathode facilitates efficient electron transfer without relying on conventional catalysts. Together, these modifications yield a 52.42% increase in the …

Diverse Genome Structures Among Eukaryotes May Have Arisen In Response To Genetic Conflict, Elinor G. Sterner, Auden Cote-L’Heureux, Xyrus X. Maurer-Alcalá, Laura A. Katz

Biological Sciences: Faculty Publications

In contrast to the typified view of genome cycling only between haploidy and diploidy, there is evidence from across the tree of life of genome dynamics that alter both copy number (i.e. ploidy) and chromosome complements. Here, we highlight examples of such processes, including endoreplication, aneuploidy, inheritance of extrachromosomal DNA, and chromatin extrusion. Synthesizing data on eukaryotic genome dynamics in diverse extant lineages suggests the possibility that such processes were present before the last eukaryotic common ancestor. While present in some prokaryotes, these features appear exaggerated in eukaryotes where they are regulated by eukaryote-specific innovations including the nucleus, complex cytoskeleton, …

Duff Center Opens, Expands Stem Opportunities At Ole Miss, Clara Turnage

University of Mississippi News

OXFORD, Miss. – University of Mississippi officials cut the ribbon on the university's largest academic building ever Thursday (Nov. 7) after completing construction on the 202,000 square-foot building earlier this fall.

Review Of Laboratory Manual: General Chemistry I Honors- First Edition, Zohra Azim

Open Educational Resources - Reviews

No abstract provided.

Brain Metastases In Sarcomas: A Multicenter Retrospective Cohort Study, Ellen Zhang, Sheima Farag, Hilary Dietz, Daniel Wang, Angela Hirbe, Kristen Ganjoo, Brian Van Tine, Shane Zaid, Aisha Miah, Vicki Keedy, Elizabeth Davis, Nam Bui

2020-Current year OA Pubs

PURPOSE: Brain metastases (BM) in sarcomas occur rarely and are associated with poor prognosis. This study is a large retrospective cohort describing the demographic and clinical characteristics of these patients, treatment strategies, and survival outcomes.

METHODS: In total, 81 patients with BM from sarcomas were identified across five sarcoma centers. Demographic data, clinical presentation, and treatment modalities were analyzed.

RESULTS: The most common histologies were leiomyosarcoma (12.3%) and undifferentiated pleomorphic sarcoma (12.3%). The median time from sarcoma diagnosis to brain metastases was 1.9 years. Upon presentation, 88.9% of patients with BM from sarcomas were symptomatic with the most common presenting …

November 7, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Digital Microfluidic Oligonucleotide Synthesis: Automated Assembly Of Dna Products In Air And Oil With Integrated On-Chip Incubation, Sari Houchaimi

Theses

Production of accurate DNA products is essential for many biological applications including drug development and delivery, synthetic biology, molecular engineering and epigenetics. It is difficult to build long DNA chains accurately and repeatably with conventional methods such as phosphoramidite method and polymerase chain assembly. DNA aqueous enzymatic assembly is a promising alternative. Multiple DNA fragments can be reliably and consistently assembled into one product using engineering enzymes in an aqueous medium. Digital Microfluidics uses asymmetric electric fields to simultaneously manipulate multiple reagent droplets on an array of electrodes. This platform is biocompatible and easily controllable. It has been used for …

Addressing Practice Effects In Population-Based Studies Of Trends In Late-Life Dementia And Cognitive Impairment, Vicki A Freedman, Mengyao Hu

Faculty, Staff and Student Publications

No abstract provided.

Perceptions Of Family Resiliency Among Adult Children Of Parents Diagnosed With Borderline Personality Disorder, Ashley D. Shulski

Walden Dissertations and Doctoral Studies

Adults who grew up experiencing childhood maltreatment may struggle more frequently with interpersonal relationships and may have low resilience, which may create ongoing struggles with having meaningful, healthy relationships with others, especially within their parent–child relationships. Individuals diagnosed with borderline personality disorder (BPD) are 13 times more likely to endorse multiple childhood adverse experiences (ACEs) than their peers and struggle to have a secure attachment to others. However there has been limited research focused on exploring parental availability and family resilience in a home with a parent diagnosed with BPD, addressing low emotional availability and parent–child bonding. This qualitative study …

Mark2 Variants Cause Autism Spectrum Disorder Via The Downregulation Of Wnt/Β-Catenin Signaling Pathway., Maolei Gong, Jiayi Li, Zailong Qin, Matheus Vernet Machado Bressan Wilke, Yijun Liu, Qian Li, Haoran Liu, Chen Liang, Joel A. Morales-Rosado, Ana S A Cohen, Susan S. Hughes, Bonnie Sullivan, Valerie A. Waddell, Marie-José H. Van Den Boogaard, Richard H. Van Jaarsveld, Ellen Van Binsbergen, Koen L. Van Gassen, Tianyun Wang, Susan M. Hiatt, Michelle D. Amaral, Whitley V. Kelley, Jianbo Zhao, Weixing Feng, Changhong Ren, Yazhen Yu, Nicole J. Boczek, Matthew J. Ferber, Carrie Lahner, Sherr Elliott, Yiyan Ruan, Cyril Mignot, Boris Keren, Hua Xie, Xiaoyan Wang, Bernt Popp, Christiane Zweier, Juliette Piard, Christine Coubes, Frederic Tran Mau-Them, Hana Safraou, A Micheil Innes, Julie Gauthier, Jacques L. Michaud, Daniel C. Koboldt, Odent Sylvie, Marjolaine Willems, Wen-Hann Tan, Benjamin Cogne, Claudine Rieubland, Dominique Braun, Scott Douglas Mclean, Konrad Platzer, Pia Zacher, Henry Oppermann, Lucie Evenepoel, Pierre Blanc, Laïla El Khattabi, Neshatul Haque, Nikita R. Dsouza, Michael T. Zimmermann, Raul Urrutia, Eric W. Klee, Yiping Shen, Hongzhen Du, Leonard Rappaport, Chang-Mei Liu, Xiaoli Chen

Manuscripts, Articles, Book Chapters and Other Papers

Microtubule affinity-regulating kinase 2 (MARK2) contributes to establishing neuronal polarity and developing dendritic spines. Although large-scale sequencing studies have associated MARK2 variants with autism spectrum disorder (ASD), the clinical features and variant spectrum in affected individuals with MARK2 variants, early developmental phenotypes in mutant human neurons, and the pathogenic mechanism underlying effects on neuronal development have remained unclear. Here, we report 31 individuals with MARK2 variants and presenting with ASD, other neurodevelopmental disorders, and distinctive facial features. Loss-of-function (LoF) variants predominate (81%) in affected individuals, while computational analysis and in vitro expression assay of missense variants supported the effect of …

Estimating The Number Of Polygenic Diseases Among Six Mutually Exclusive Entities Of Non-Tumors And Cancer, C I Edvard Smith, Jan A Burger, Rula Zain

Faculty, Staff and Student Publications

In the era of precision medicine with increasing amounts of sequenced cancer and non-cancer genomes of different ancestries, we here enumerate the resulting polygenic disease entities. Based on the cell number status, we first identified six fundamental types of polygenic illnesses, five of which are non-cancerous. Like complex, non-tumor disorders, neoplasms normally carry alterations in multiple genes, including in 'Drivers' and 'Passengers'. However, tumors also lack certain genetic alterations/epigenetic changes, recently named 'Goners', which are toxic for the neoplasm and potentially constitute therapeutic targets. Drivers are considered essential for malignant transformation, whereas environmental influences vary considerably among both types of …

Seventh-Day Adventist Clergy’S Perceptions Of Dealing With Parishioners’ Mental And Emotional Health Challenges, Allens Gilles

Walden Dissertations and Doctoral Studies

The issue of how Seventh-day Adventist (SDA) clergy perceive and address parishioners’ mental health challenges is critical. Clergy perceptions are significant because they can greatly influence parishioners’ quality of life and choices regarding mental health care. However, there is limited literature on SDA clergy’s perspectives on these matters. Thus, the purpose of this qualitative phenomenological study was to explore the perceptions of SDA clergy regarding how to assist parishioners with emotional and mental health challenges. The theoretical framework was the mental health literacy theory, developed in the mid-1990s. Data were collected from semistructured interviews with 10 clergy of African American …

Metallomic Approach To Mercury And Selenium In The Liver Tissue Of Psectrogaster Amazonica And Raphiodon Vulpinus From The Brazilian Amazon, Izabela Bataglioli, José Vieira, Joyce Da Siva, Luane Andrade, Victor Faria, Rebeca Corcoba, Ronaldo De Almeida, Luiz Zara, Marília Buzalaf, Jiri Adamec, Pedro Padilha

School of Medicine Faculty Publications

This paper reports the results of a mercury (Hg) and selenium (Se) metallomic study in the liver tissues of Psectrogaster amazonica and Raphiodon vulpinus from the Brazilian Amazon. Two-dimensional electrophoresis, graphite furnace atomic absorption spectrometry, and liquid chromatography-tandem mass spectrometry were performed. Hg and Se determinations allowed the calculation of Hg:Se and Se:Hg molar ratio and Se values for health benefits (Se HBVs). The Se:Hg values were >1 for both fish species, whereas the Se HBVs were >5 for P. amazonica and >10 for R. vulpinus, indicating that both possess Se reserves to control Hg toxicity. The metallomic data allowed …

Comparing Fermented Food And Vitamin E On Exercise-Mediated Nrf2/Are Activation In Middle-Aged/ Elderly: A Randomized, Double-Blind Clinical Study, Joseph Cervi, Reza Rastmanesh, Amir Moghadam-Ahmadi, Antonio Ayala, Cristiana Aperio, Aldo Lorenzetti, Maki Osato, Francesco Marotta, Antonio Nardin, Fang He

Department of Neuroscience Faculty Papers

Background: There is a compelling need to emphasize the importance of deepening the rationale behind functional foods research in molecular biology. Indeed, establishing stringent criteria to evaluate functional food interventions in disease prevention and as adjunctive therapeutic strategies offers significant opportunities for health promotion. Objective: This study investigated the effects of fermented papaya preparation (FPP®) and vitamin E on gene expression in middle-aged/elderly individuals, leveraging FPP’s established antioxidant and immune-regulatory benefits. Methods: Graded Exercise Walking Test was administered twice weekly for 6 months. Total Antioxidant capacity (TAC) and gene expression (Nrf2, NQO1, HO-1) in PBMC were measured monthly. Results: Throughout …

Large-Scale Application Of Clingen-Insight Apc-Specific Acmg/Amp Variant Classification Criteria Leads To Substantial Reduction In Vus, Xiaoyu Yin, Marcy Richardson, Andreas Laner, Xuemei Shi, Elisabet Ognedal, Valeria Vasta, Thomas V O Hansen, Marta Pineda, Deborah Ritter, Johan De Dunnen, Emadeldin Hassanin, Wencong Lyman Lin, Ester Borras, Karl Krahn, Margareta Nordling, Alexandra Martins, Khalid Mahmood, Emily Nadeau, Victoria Beshay, Carli Tops, Maurizio Genuardi, Tina Pesaran, Ian M Frayling, Gabriel Capellá, Andrew Latchford, Sean V Tavtigian, Carlo Maj, Sharon E Plon, Marc S Greenblatt, Finlay A Macrae, Isabel Spier, Stefan Aretz

Faculty, Staff and Students Publications

Pathogenic constitutional APC variants underlie familial adenomatous polyposis, the most common hereditary gastrointestinal polyposis syndrome. To improve variant classification and resolve the interpretative challenges of variants of uncertain significance (VUSs), APC-specific variant classification criteria were developed by the ClinGen-InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel (VCEP) based on the criteria of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP). A streamlined algorithm using the APC-specific criteria was developed and applied to assess all APC variants in ClinVar and the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) international reference APC Leiden Open Variation …

Brain Metastases In Sarcomas: A Multicenter Retrospective Cohort Study, Ellen Zhang, Sheima Farag, Hilary Dietz, Daniel Wang, Angela Hirbe, Kristen Ganjoo, Brian Van Tine, Shane Zaid, Aisha Miah, Vicki Keedy, Elizabeth Davis, Nam Bui

Faculty, Staff and Students Publications

Purpose: Brain metastases (BM) in sarcomas occur rarely and are associated with poor prognosis. This study is a large retrospective cohort describing the demographic and clinical characteristics of these patients, treatment strategies, and survival outcomes.

Methods: In total, 81 patients with BM from sarcomas were identified across five sarcoma centers. Demographic data, clinical presentation, and treatment modalities were analyzed.

Results: The most common histologies were leiomyosarcoma (12.3%) and undifferentiated pleomorphic sarcoma (12.3%). The median time from sarcoma diagnosis to brain metastases was 1.9 years. Upon presentation, 88.9% of patients with BM from sarcomas were symptomatic with the most common presenting …

Homozygous Variants In Wdr83os Lead To A Neurodevelopmental Disorder With Hypercholanemia, Scott Barish, Sheng-Jia Lin, Reza Maroofian, Alper Gezdirici, Hamoud Alhebby, Aurélien Trimouille, Marta Biderman Waberski, Tadahiro Mitani, Ilka Huber, Kristian Tveten, Øystein L Holla, Øyvind L Busk, Henry Houlden, Ehsan Ghayoor Karimiani, Mehran Beiraghi Toosi, Reza Shervin Badv, Paria Najarzadeh Torbati, Fatemeh Eghbal, Javad Akhondian, Ayat Al Safar, Abdulrahman Alswaid, Giovanni Zifarelli, Peter Bauer, Dana Marafi, Jawid M Fatih, Kevin Huang, Cassidy Petree, Daniel G Calame, Charlotte Von Der Lippe, Fowzan S Alkuraya, Sami Wali, James R Lupski, Gaurav K Varshney, Jennifer E Posey, Davut Pehlivan

Faculty, Staff and Students Publications

WD repeat domain 83 opposite strand (WDR83OS) encodes the 106-aa (amino acid) protein Asterix, which heterodimerizes with CCDC47 to form the PAT (protein associated with ER translocon) complex. This complex functions as a chaperone for large proteins containing transmembrane domains to ensure proper folding. Until recently, little was known about the role of WDR83OS or CCDC47 in human disease traits. However, biallelic variants in CCDC47 were identified in four unrelated families with trichohepatoneurodevelopmental syndrome, characterized by a neurodevelopmental disorder (NDD) with liver dysfunction. Three affected siblings in an additional family share a homozygous truncating WDR83OS variant and a phenotype of …

Vol. 36, No. 8 - Whole No. 209, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

More Than Simple Plagiarism: Ligotti, Pizzolatto, And True Detective’S Terrestrial Horror, Jonathan Elmore

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Of course, True Detective is neither a philosopher’s bedtime story nor supernatural horror, and yet there remains a productive affinity between Ligotti’s work and the HBO series. Where Ligotti provides substantial portions of the hallmark character’s identity and dialogue, True Detective puts Ligotti’s thought experiment to far more practical uses than does Ligotti himself. By intertwining hurricanes and flooding alongside industry and pollution into the background and negative space of the setting, the series implicates the urgent material reality of climate change and environmental collapse into the setting: “all of this is going to be under water in thirty years” …

Physiochemical Characterization And In-Vitro Investigation Of The Effect Of Commercial And Novel Non-Digestible Fiber/Prebiotics On The Growth Of Probiotics, Shaikha Salem Al Ameri

Thesis/ Dissertation Defenses

Probiotics and prebiotics play a major role in enhancing the gut microbiota and, consequently, human health. Non-digestible dietary fibers (prebiotics) are selectively fermented and induce specific changes in the composition and/or activity of the gastrointestinal microbiota (probiotics), thus conferring benefit(s) upon the host's health. The consumption of prebiotic products has been extended from diet supplementation to clinical application in various health complications, emerging as a potential therapeutic to manipulate several diseases. Different pharmaceutical companies normally use a blend of many fibers from various sources to prepare commercial prebiotic products. Currently, no data is available to what extent the components of …

Michigan Academician, Volume 48, Issue 2

Michigan Academician

No abstract provided.

Michigan Academician, Volume 48, Issue 3

Michigan Academician

No abstract provided.

The Parthenon, November 06, 2024, Evan Green, Sarah Davis, Baylee Parsons, Joseph Dicristofaro, Kaitlyn Fleming, Scott Price, Abigail Cutlip, Rafael Alfonso, Wade Sullivan

The Parthenon

No abstract provided.