Digital Commons Network^™

A Phenomenographic Analysis Of Undergraduate Student Perceptions Of The Geosciences And Geoscience Careers, Leah M. Wiitablake

All Dissertations

The climate crisis is upon us, whether we like it or not, and its undeniable effects are evident. Take, for example, Hurricane Helene, which caused unimaginable devastation to what was once considered a “climate haven,” Asheville, NC (Andreoni, 2024; Medina & Fausset, 2024). Hurricane Helene made landfall as a Category 4, jumping from a Category 1 in less than 24 hours (Andreoni, 2024), and is noted by the National Hurricane Center as a major hurricane (National Hurricane Center & Central Pacific Hurricane Center, 2024). With the Earth now unlikely to remain below 1.5°C of warming (IPCC, 2023b), perhaps we can …

Quantifying Greenhouse Gas Exchange And Ecosystem Services In Ecosystems Managed For Nature-Based Solutions Using Eddy Covariance, Remote Sensing, And Models, Lucas Clay

All Dissertations

As global temperatures rise due to climate change, nature-based solutions are increasingly being used to restore nature and to remove carbon from the atmosphere. Nature-based solutions draw on methodologies such as ecological forestry and improved forest management to reduce emissions and maximize resilience. These protocols are still in their infancy and additional measurements and case studies are important to optimizing these protocols. Herein this dissertation we describe multiple measurement methodologies for both greenhouse gas (GHG) emissions and for ecosystem services. In coastal wetland ecosystems, the need for GHG measurements is paramount to understanding the ability of these ecosystems to reduce …

Neural Operator And Physics-Informed Deep Learning Approaches For Inverse Design Of Composites And Manufacturing Processes, Minglei Lu

All Dissertations

In this dissertation, artificial intelligence (AI) models are designed and used to accelerate inverse design of composites and manufacturing processes. The critical bottlenecks in machine learning (ML) including data availability, data quality, model generalization and adaptation, interpretability, physical consistency, and the ’black box’ nature of models for the inverse design are addressed. And the proposed AI models are tested under different engineering scenarios. Firstly, a fast deep neural operator (DNO) structure was developed to significantly reduce training time. This model was tested in the context of additive manufacturing, a transformative industrial technology that allows for the creation of materials with …

Polymersomes As Chemotherapeutic Agents Towards Non-Invasive Treatment Of Glioblastoma, Molli Garifo

All Dissertations

Glioblastoma (GBM) accounts for over 66% of all malignant central nervous system and brain tumors with a 5-year survival rate below 5%, which has remained relatively unchanged over the last four decades. To bypass the most challenging barrier to treatment, the blood-brain barrier (BBB), one intracranial implant is clinically available for GBM treatment. However, this treatment produces severe adverse effects with no significant improvements in patient outcomes. Developing an improved delivery system with a more effective chemotherapy drug will provide more controlled and specific treatment through local delivery. In this dissertation, I evaluate a hyaluronic acid-b-polylactic acid (HA-PLA) polymersome system …

The Impact Of Food Law Policies On Local Community Empowerment In Indonesia’S Sustainable Food Garden Program, Tiyas Vika Widyastuti, Achmad Irwan Hamzani, Anis Masdurohatun

Indonesia Law Review

This research examines the impact of food law politics on community empowerment and sustainable agriculture in Indonesia, focusing on the Sustainable Food Garden Program (P2L). Utilizing a normative juridical analysis, it explores how legal frameworks can support or obstruct community-led agricultural initiatives. The study highlights the empowering effect of laws aligned with community goals and the challenges arising from legislation favoring industrial agriculture. It proposes legal reforms to address ambiguities and barriers, such as clarifying land tenure rights and simplifying organic certification processes. Recommendations aim to foster a legal environment conducive to sustainable, community-driven agriculture, enhancing food security and environmental …

Prevalence Of Autism Spectrum Characteristics In Students Taking Undergraduate Computing Courses, Rachel Michaela Mettenbrink

School of Computing: Dissertations, Theses, and Student Research

The incidence rate of autism spectrum condition (ASC) has increased significantly in recent decades, as awareness of the condition and its impacts increases amongst clinicians, parents, and the general population. Medical literature has proposed that there may be a relationship between ASC and participation in the computing field. This study tests for the prevalence of autism spectrum condition traits measured by delivering the Autism Spectrum Quotient (AQ) to a population of undergraduate computer science students. We examine the relationships between AQ scores and students taking undergraduate computer science classes, sex, socioeconomic status, and parents in the computing industry. Additionally, we …

Enhancing Ai Ethics Through Integrating Aif360 With Generative Ai, Christina Ieisha Hastings

All Dissertations

In recent years, Artificial Intelligence (AI) has brought about significant positive changes in people's lives with respect to convenience and efficiency. The primary aim of AI is to emulate human intelligence in machines, creating a system capable of thinking and replicating human cognitive functions. AI encompasses tasks that mirror human behaviors, such as visual perception, speech recognition, and language translation.

The realm of AI ethics is an evolving and interdisciplinary field dedicated to addressing ethical considerations in AI. The establishment of ethical standards for AI is vital for developing morally upright AI systems and ensuring ethical conduct in AI applications. …

(R2098) Dynamic Analysis Of Stochastic Leslie-Gower Biological Predator-Prey Model With Prey Cannibalism, Sada Nand Prasad, Itendra Kumar Universiry Of Delhi, India, Pawan Kumar

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we study the dynamical analysis of a stochastic Leslie–Gower biological predator– prey model. Earlier, the Leslie–Gower model was studied in the context of biological systems, including cases involving cannibalism. In our model, we investigate the dynamic properties of a stochastic Leslie–Gower predator–prey ecological system using the stability of invariant measures on invariant sets, where the invariant measures are shown to be ergodic. We also conduct a threshold analysis to study the stochastic persistence and extinction of species. Stochastic bifurcation is also examined. The theoretical results are supported by numerical simulations and examples. Intra-species competition is considered and …

Death And Words As Witness In Post-War Literature: Salvation Narratives In Markus Zusak’S The Book Thief, Lusa Holmstrom

FCRH Honors Program Theses

Death didn’t used to be so taboo. As late as the 18th century, death was a prominent aspect of literature, and people of all ages were invited to the deathbeds of family members and friends alike. In the Victorian era, death was so much a culture as was living. But with the rise of preventative medicine in the late 19th and early 20th centuries, the view of death in the western world, specifically, took a turn. As Geoffrey Gorer argues in his 1955 article “The Pornography of Death,” higher mortality rates allowed for greater familiarity and intimacy with death, while …

Exploring The Therapeutic Benefits Of Dance In The Academic Schedule: The Effects On Stress Among High School Students, Amanda Polanowski

Master's Theses

The purpose of this study was to gain insight into the minds of dance students about the stress they experienced as a result of their academic schedules and extracurriculars. The following research questions informed this study:

Q1 Does incorporating dance into the academic schedule lower stress in high school students?

Q2 In what mental state are students before and after taking dance class?

Q3 Does dance provide mental health benefits for high school students?

Student stress was evaluated before the study using a questionnaire as well as before and after each dance class through surveys. Eighteen students participated in a …

Cryoablation Of Primary Breast Cancer Tumors Induces A Systemic Abscopal Effect Altering Time (Tumor Immune Microenvironment) In Distant Tumors, Flávia Sardela De Miranda, Dalia Martinez-Marin, Rachel L. Babcock, Maribel Castro, Geetha P. Boligala, Sonia Y. Khan, Kathryn L. Furr, Isabel Castro-Piedras, Nicholas Wagner, Dakota E. Robison

School of Medicine Publications

Introduction: Despite recent advances, triple-negative breast cancer (TNBC) patients remain at high risk for recurrence and metastasis, which creates the need for innovative therapeutic approaches to improve patient outcomes. Cryoablation is a promising, less invasive alternative to surgical resection, capable of inducing tumor necrosis via freeze/thaw cycles. Necrotic cell death results in increased inflammatory signals and release of preserved tumor antigens, which have the potential to boost the local and systemic anti-tumor immune response. Thus, compared to surgery, cryoablation enhances the activation of T cells leading to an improved abscopal effect, defined as the occurrence of a systemic response after …

Accelerating Heritability, Genetic Correlation, And Genome-Wide Association Imaging Genetic Analyses In Complex Pedigrees, Brian Donohue, Si Gao, Thomas E. Nichols, Bhim M. Adhikari, Yizhou Ma, Neda Jahanshad, Francis J. Mcmahon, Elizabeth M. Humphries, William Burroughs, John Blangero

School of Medicine Publications

National and international biobanking efforts led to the collection of large and inclusive imaging genetics datasets that enable examination of the contribution of genetic and environmental factors to human brains in illness and health. High-resolution neuroimaging (~104–6 voxels) and genetic (106–8 single nucleotide polymorphic [SNP] variants) data are available in statistically powerful (N = 103–5) epidemiological and disorder-focused samples. Performing imaging genetics analyses at full resolution afforded in these datasets is a formidable computational task even under the assumption of unrelatedness among the subjects. The computational complexity rises as ~N2–3 (where N is the sample size), when …

Lipid-Based Niclosamide Delivery: Comparative Efficacy, Bioavailability, And Potential As A Cancer Drug, Jihoo Woo, Russel Wiggins, Shizue Mito

School of Medicine Publications

Niclosamide, an FDA-approved anti-parasitic drug, has demonstrated significant potential as a repurposed anti-cancer agent due to its ability to interfere with multiple oncogenic pathways. However, its clinical application has been hindered by poor solubility and bioavailability. Lipid-based nanocarrier systems such as liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and lipid nanoemulsions (LNE), along with lipid prodrugs, have successfully been employed by researchers to overcome these limitations and improve niclosamide’s pharmacokinetic profile. Lipids are the core organic compounds which serve as the foundation of these advanced drug delivery methods and in turn play a critical role in enhancing niclosamide’s …

Validation Of Human Telomere Length Multi-Ancestry Meta-Analysis Association Signals Identifies Pop5 And Kbtbd6 As Human Telomere Length Regulation Genes, Rebecca Keener, Surya B. Chhetri, Carla J. Connelly, Margaret A. Taub, Matthew P. Conomos, Joshua Weinstock, Bohan Ni, Benjamin Strober, Stella Aslibekyan, John Blangero

School of Medicine Publications

Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere length regulation. We conducted a multi-ancestry meta-analysis of 211,369 individuals and identified five novel association signals. Enrichment analyses of chromatin state and cell-type heritability suggested that blood/immune cells are the most relevant cell type to examine telomere length association signals. We validated specific GWAS associations by overexpressing KBTBD6 or POP5 and demonstrated that both lengthened telomeres. CRISPR/Cas9 deletion of the predicted causal regions in K562 blood cells reduced expression of …

Oh, My Quad: A Clinical Commentary And Evidence-Based Framework For The Rehabilitation Of Quadriceps Size And Strength After Anterior Cruciate Ligament Reconstruction, Braidy Solie, Mitchell Carlson, Christopher Doney, Michael Kiely, Robert Laprade

Physical Therapy Faculty Research and Publications

Quadriceps weakness after anterior cruciate ligament reconstruction (ACLR) is a well-known phenomenon, with more persistent quadriceps weakness observed after ACLR with a bone-patellar tendon-bone or quadriceps tendon autograft than with a hamstring tendon autograft. Longstanding quadriceps weakness after ACLR has been associated with suboptimal postoperative outcomes and the progression of radiographic knee osteoarthritis, making the recovery of quadriceps size and strength a key component of ACLR rehabilitation. However, few articles have been written for the specific purpose of optimizing quadriceps size and strength after ACLR. Therefore, the purpose of this review article is to integrate the existing quadriceps muscle basic …

Racial Disparities In Domestic Violence: Analyzing The Intersection Of Race And Gender, Nia Grace Sharp

Honors Theses

This research explores the intersection of race, gender, and the litigation of domestic violence cases in Memphis, Tennessee. This is explored through qualitative research that combines a theoretical framework with structured interviews of criminal defense attorneys. Utilizing a sample of 5 attorneys with recent exposure to domestic violence cases, this study aims to reveal whether or not intimate partner violence is litigated differently across racial lines. This is done through analysis of the treatment of victims depending on race, sentencing rates, and perceptions of credibility within the justice system. The methodology involves five key steps: conducting a literature review to …

Parental Guidance Necessary: A Qualitative Study On The Impacts Of Parenting Styles, Mackenzie Longmire

Honors Theses

This thesis examines the long-term effects of parenting styles and attachment experiences on adult psychological well-being, relational competence, academic aspirations, and self-concept. Through qualitative analysis of semi-structured interviews with three participants from the Chattanooga, Tennessee area, the study investigates how family dynamics—framed by Baumrind’s parenting models and Bowlby’s attachment theory—shape developmental trajectories across the lifespan. Findings indicate that authoritative parenting fosters resilience, empathy, and secure attachments, while authoritarian and avoidant parenting styles often lead to relational hesitancy and diminished self-worth. Emphasizing the value of responsive, balanced parenting, this study underscores its role in promoting emotional security and adaptive coping, with …

Waste Recycling Strategy And Its Role In Enhancing The Dimensions Of Sustainable Development In Iraq, Mustafa H. Kzar, Hamdia Shaker Moslem

Journal of Economics and Administrative Sciences

Purpose: The aim of this study was to determine the importance of waste recycling in addressing economic, social and environmental problems facing most countries of the world, especially developing countries, including Iraq, Where Iraq has not developed a recycling strategy for waste considering the economic and climatic changes that the world is witnessing with the increase in population growth rates and the expansion of cities. Theoretical Framework: Many economists, such as (Kirrchher J., & et al., 2017; Murray, A., & et al., 2015; Prieto-Sandoval V. & et al., 2018; Williams, 2013) have also highlighted the importance of practices in production …

Evaluation Of The Etiology Of Recurrent Pregnancy Loss (Rpl): An Explanatory Mixed Methods Study Exploring Obstetrician Gynecologist Clinical Provider Behaviors And Factors Contributing To Incomplete Evaluations, Emelia Grant

Doctor of Philosophy in Translational Health Sciences Dissertations

Background: More than 50% of patients with recurrent pregnancy loss (RPL) are left without explanations for their losses. However, current research suggests that up to 90% of these individuals could receive explanations through evidence-based laboratory testing. Professional guidelines vary in their recommendations for laboratory testing and RPL evaluation, which can contribute to delayed or fragmented care and untreated maternal disease. Inequities in access to genetic testing further complicate the diagnostic landscape of RPL since payor policies often determine which tests are covered, leaving many patients without access due to financial constraints.

Objective: This study aimed to evaluate current practices of …

Teaching Learning Newsletter Vol 4 Issue 2, Sastra Deemed To Be University

TLC Newsletter

No abstract provided.

U-Glide Program Fall 2024, Unf Office Of Undergraduate Research, Unf Graduate School

Undergraduate – Graduate Learning, Inquiry, and Distinctive Experimentation (U-GLIDE) Symposium Programs

No abstract provided.

Young Adults’ Perceptions Of Adverse Childhood Experiences As Context And Causes Of Mental Health Conditions: Observations From The United States, Kathryn Sabella, Ian A. Lane, Murron O'Neill, Natalie Tincknell

Faculty Publications (Peer-Reviewed)

Background

Objective

Participants and setting

Methods …

Spatial-Textural Study Of Siliciclastics In A Navajo Sandstone Carbonate Lens, Christopher L. Rupe

Loma Linda University Electronic Theses, Dissertations & Projects

Flat-lying carbonate deposits in the Lower Jurassic Navajo Sandstone have long been interpreted as interdune lacustrine deposits. This dissertation critically assesses such inference through the study of an exceptionally well-preserved carbonate deposit in the Trough Canyon area, northwest of Moab, Utah. Thickness measurements along multiple cross-sectional exposures were used to construct an isopach map, approximating the original size and lenticular geometry of the deposit. Dip directions were recorded from foreset strata in cross-bed sets stratigraphically overlying the deposit to infer the approximately coeval direction of siliciclastic transport across the carbonate basin. These data sets yielded a contextual framework for studying …

Microplastic Degradation Compared Among Dated Salton Sea Strandlines, Maria Alejandra Roman Medrano

Loma Linda University Electronic Theses, Dissertations & Projects

This thesis investigates the environmental degradation of plastic materials, with a focus on polyethylene terephthalate (PET), through a multi-phase study conducted at the Salton Sea, a closed-basin lake in a semi-arid region of California. The research addresses three core objectives: (1) developing a microplastic (MP) extraction method tailored for clay-rich sediments, (2) characterizing surface degradation of various plastic types, including PET, BoPET, HDPE, LDPE, and EPS, using advanced microscopy and spectroscopy, and (3) examining the long-term weathering of PET through samples collected from dated lake strandlines.

The extraction protocol successfully isolates MPs without oxidation, using ZnCl₂ and extended soaking to …

Characterizing Tropical Forest Structure Using Semivariance And Crown Delineation, Brittani Joy Evon Chapman

Master's Theses and Capstones

The study of terrestrial carbon stocks is essential to understand global carbon cycles and the magnitude of anthropogenic carbon emissions. Forests are significant terrestrial carbon stores, with the above ground biomass of the Brazilian rainforest alone conservatively estimated to contain ten percent of the terrestrial carbon stock (Asner et al., 2001; Drake et al., 2002; Keller et al., 2004; Lloyd et al., 2007; Truehaft et al., 2014; Cushman et al., 2021). The Amazon Basin primarily consists of closed-canopy tropical forest, covering 5.8 x 106 km2 interspersed with substantial portions of cerrado surrounding the Amazon River and its tributaries in the …

Behavioral And Physiological Effects Of Ocean Acidification On Juvenile American Lobsters (Homarus Americanus), Todd Edward Stelling

Master's Theses and Capstones

Increased absorption of anthropogenic carbon dioxide (CO2) into the world’s oceans has resulted in ocean acidification (OA). Acidification induces physiological and behavioral responses from marine invertebrates that vary by taxa. Resilience to OA has been noted in crustaceans, though negative impacts are still reported. It has been shown that the American lobster (Homarus americanus) can be physiologically impacted by acidified conditions. We explored the effects of acidification on the hemolymph chemistry and the foraging behavior of juvenile American lobsters (carapace length, CL, 29 - 52 mm, 42 +/- 1.3 mm). We exposed 28 juvenile lobsters to individual pH values ranging …

Synthesis And Testing Of Peptide Iron Probes In Cell Studies, Fran Gomez

Master's Theses and Capstones

The study of iron within cells has advanced significantly since the Fenton reaction was proposed as a mechanism for ferroptosis. Various chemical probes have been developed for examining iron and reactive oxygen species (ROS), both of which are involved in the Fenton reaction. Iron, the most abundant transition metal in the human body, primarily exists as Fe(II) and Fe(III) in the cellular environment. The labile iron pool (LIP) is suspected to predominantly exist as Fe(II) due to endogenous reductants. Under ferroptotic conditions, Fe(III) produced in the Fenton reaction can be reduced back to Fe(II), even when chelated, re-inducing hydroxyl radical …

Identification Of Lncrnas Involved In The Host Response To Venezuelan Equine Encephalitis Virus Infection, Mahgol Behnia

Biomedical Sciences ETDs

Venezuelan equine encephalitis virus (VEEV) is an enveloped positive-sense RNA virus in the alphavirus genus of the Togaviridea family, that causes encephalitis in humans and equids. Currently no FDA-approved vaccine or treatment is available for human use, emphasizing the importance of studying host-VEEV interaction. lncRNAs are regulatory RNAs involved in modulation of antiviral pathways during viral infections. Here we report differential lncRNAs expression in primary mouse astrocytes and neurons during non-pathogenic (TC-83) but not pathogenic (TrD) VEEV infection. We further demonstrated that suppression of four lncRNAs increased TC-83 replication, with lncRNA small nucleolar RNA host gene 15 (Snhg15) increasing TC-83 …

Timigp: A Computational Framework To Determine The Tumor Immune Microenvironment Associated With Prognosis And Immunotherapy Response, Chenyang Li

Dissertations and Theses (Open Access)

Accumulating evidence has suggested that the tumor immune microenvironment (TIME) drastically impacts cancer patients’ clinical outcomes, including prognosis and immunotherapy response. However, understanding TIME remains challenging due to its complexity and heterogeneity. In this dissertation, we introduce TimiGP (Tumor Immune Microenvironment Illustration based on Gene Pairs), a computational framework designed to address this challenge. Leveraging single-cell RNA-seq (scRNA-seq) and bulk gene expression data alongside clinical information, TimiGP constructs a cell-cell interaction network that elucidates the relationship between immune cell function and relevant clinical outcomes, such as prognosis and treatment response. With immunological insights, these cell-cell interactions also facilitate the development …

The Role Of Wt1 In Müllerian Duct Development, Jace Aloway

Dissertations and Theses (Open Access)

WT1 is a zinc finger transcription factor widely expressed in the urogenital system. Human mutations of WT1 lead to pediatric nephroblastoma as well as frequent differences of sex development (DSDs). Previous studies have suggested that WT1 acts as an activator for Amhr2, a necessary component of typical male differentiation. We used the mouse as a model to investigate the role of WT1 in sex development, where we deleted Wt1 in the Müllerian duct (MD) mesenchyme using a novel conditional null reporter allele, Wt1 flox-RFP. This allele utilizes the Cre-lox system to delete exons 8 and 9 of Wt1 …