Quantitative Analysis Of Protective Effect Of Resveratrol Against Nanoplastic-Induced Oxidative Stress, Bryan Gustafson

All Graduate Reports and Creative Projects, Fall 2023 to Present

Nanoplastics and microplastics are a growing ecological and health concern due to their widespread prevalence. The effects of these microscopic particles in biological systems primarily relate to their potential to produce reactive oxygen species and interactive effects with other cytotoxic agents. Of particular interest in this work is the effect on mammalian intestinal cells, due to the regular unintentional ingestion of micro- and nanoplastics in the normal western diet. In this study, Caco-2 cells were cultured and exposed to polystyrene particles in vitro as a simple model of the human digestive endothelium.

Resveratrol, a naturally occurring polyphenolic compound, has been …

Evaluating The Duckweeds Lemna Minor And Spirodela Polyrhiza As Alternative Aquatic Hosts For The Spread Of The Bacterial Wilt Pathogen, Ralstonia Solanacearum, Irelynn Smith

Honors Theses

Ralstonia solanacearum is a plant pathogen that causes bacterial wilt disease in major crops such as tomatoes and potatoes. Recently, this bacterium was discovered in floating pennywort (Hydrocotyle ranunculoides) and Pennsylvania smartweed (Polygonum pennysylvanicum), two previously unsuspected aquatic plants. Duckweed is an aquatic plant with a high level of resilience and short doubling time. Common duckweed (Lemna minor) has previously demonstrated its capability as a versatile high-yield infection model for other types of pathogenic bacteria. Given this newfound branch of aquatic hosts and the fact that duckweed is a common pond weed previously identified in several ponds located nearby infected …

Geomorphic Assessment And Flow Modeling Of Pearl Darter (Percina Aurora) Habitat In The Pascagoula River Watershed, Malia Davidson

Master's Theses

Freshwater ecosystems are complex ecosystems driven by hydrologic, geomorphic, and biological processes. Considering both abiotic and biotic factors is important to understanding resident species habitat. Geomorphology is a known, but often neglected factor in habitat assessment for freshwater fishes. A crucial feature commonly seen in alluvial stream systems are sandbars, which are dynamic and variable sediment structures that are known to have many associated species. One such species is the Pearl Darter, Percina aurora, a federally threatened species that only resides in the Pascagoula River watershed. Despite its status, habitat preference remains unclear. To fill this knowledge gap, I …

Lack Of Inflammatory Response In Mouse Embryonic Cells To Listeria Infection, Damilola Oyebode

Master's Theses

Approximately 1 in 5 pregnancies in the United States results in miscarriage, with a significant percentage of these losses attributed to failed implantation due to immunological challenges encountered by the early embryo. Recent research has shown that key cell types within mouse blastocysts, including embryonic stem cells (ESCs) and trophoblast stem cells (TSCs), exhibit remarkable resilience against the cytotoxic effects associated with viral infections and embryotoxic cytokines, such as TNFα and IFNγ, both of which are known to hinder blastocyst development. However, the immune properties of the preimplantation stage embryo, specifically the blastocyst, remain poorly understood. Using mouse cell model, …

Juvenile And Subadult Gulf Sturgeon (Acipenser Desotoi) Use Of The Pascagoula River Estuary, Sarah Stovall

Master's Theses

Gulf Sturgeon (GS) are an anadromous species currently listed as “Threatened” under the Endangered Species Act. They reside in habitats across the northern Gulf of Mexico including coastal rivers, estuaries, and marine waters, making annual migrations between freshwater and marine habitats for spawning/summer resting and feeding, respectively. Since past studies prioritize adult movement, understanding how and when juvenile and subadult GS use the Pascagoula River estuary (PRE), a complex, bifurcated river delta federally designated as critical habitat is necessary to improve conservation efforts. My thesis assessed juvenile and subadult GS use of the PRE across four years (2020-2024) by analyzing …

Exploring The Capabilities Of Classifier-Free Guidance In Recommendation Tasks, Noah Buchanan

Graduate Theses and Dissertations

This thesis addresses the problem of recommending items to users based on their ratings of items through a diffusion recommender system. Regular recommender systems are already capable of efficient recommendation through conventional methods such as collaborative or content-based filtering. Diffusion is a new type of generative AI that aims to improve our previous AI's shortcomings in the generative domain, like Variational Autoencoders (VAEs) and Generative Adversarial Networks (GANs). We use diffusion to create a recommender system that mirrors the sequence users take when browsing and rating items. The current methods of recommendation with diffusion do not use the new innovation …

Multimodal Spectroscopy To Study Tumor Microenvironmental Changes In Vivo, April Mordi

Graduate Theses and Dissertations

Every year there are millions of new cancer diagnoses and deaths worldwide. While great strides have been made in technologies and drugs for cancer treatment, there is still a need to understand tumor response to therapy as many patients still endure treatment failure after completing their treatment regimen. Current clinical imaging techniques for detecting response to therapy are utilized weeks to months after the course of treatment, and present limitations to measuring response during treatment. Optical spectroscopy techniques can help meet this need to determine the response of tumors to treatment as it allows for near real-time in vivo characterization …

The Impact Of Wild Pigs (Sus Scrofa) On Avian Occupancy And Vegetation Structure, Kenneth Wilson

Graduate Theses and Dissertations

Invasive species, particularly wild pigs (Sus scrofa), pose a significant threat to native ecosystems through both direct and indirect impacts. Wild pigs are large-bodied omnivorous species that can consume a wide variety of plants and animals and are known for destructive foraging behaviors, which likely threatens avian communities through habitat alteration and can impact the long term structure of ecosystems where they are present.

In chapter 1, we used a combination of avian point count surveys, vegetation assessments, and camera trap surveillance to quantify how the occupancy of breeding birds in bottomland hardwood forests changed in relation to …

Causal Discovery In Time Series Data Using Deep Learning Techniques, Saima Zahin Farhana Absar

Graduate Theses and Dissertations

Causal structure learning from observational data has been an active field of research over the past decades. In the literature, different algorithms and models have been proposed, such as constrained-based methods and score-based methods including the emerging deep learning-based methods. However, most of the approaches apply to static and non-dynamic data only. In many applications, the data is temporal. For example, monitoring systems, weather surveillance systems, and stock data, to name but a few. Incorporating temporal information is an important extension of the causal discovery field. With the growth of observational data these days, the discovery of causal relationships from …

Anti-Inflammatory Potential Of Black Cumin Seed Oil And Its Nanoemulsion Formulation Against Lipopolysaccharide-Induced Liver Injury In Mice, Shady Swidan, Hesham Hafez, Rehab Hosni, Hatem Amin

Pharmacy

Original Article

Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice

Haffez, Hesham^1,2,✉; Hosni, Rehab³; Swidan, Shady A.⁴; Amin, Hatem K.^1,5

Author Information

¹Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Helwan, 11795, Cairo, Egypt

²Center of Scientific Excellence “Helwan Structural Biology Research”, Helwan University, Helwan, 11795, Cairo, Egypt

³El Sisi Comprehensive Clinic, General Authority for Health Insurance-Giza, Haram, 12556, Giza, Egypt

⁴Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, El-Sherouk, 11837, Cairo, …

Influence Of Glycopolymer Structure On Amphiphilic, Hybrid, Linear Branched Block Copolymer Properties For Use In Biomedical Applications, Kevin Green

Dissertations

The focus of this dissertation is evaluating and adding fundamental knowledge regarding the structure-property relations of glycopolymers used in the design of hybrid block copolymers (HBC) that are cable of self-assembling into delivery vehicles for biomedical applications. A shift to the utilization of natural materials in the design and fabrication of drug-delivery vehicles has garnered significant attention. Understanding the effects of linear glycopolymers content and composition on the resulting HBCs properties can provide valuable insight into how these materials may be tailored for use in targeted biological applications.

The first chapter introduces current literature on the need for improvement in …

Inhibitory Activities Of Phytoconstituents From Azadirachta Indica And Murraya Koenigii As Potential Drugs For Secondary Infection Of Atopic Eczema Disease - In Silico Study, Mikidadi S. Gurisha, Pulapa V. Kanaka Rao, Laxmikanth Cherupally

Tanzania Journal of Science

Atopic Eczema (AE) disease is a chronic inflammatory skin condition that is caused by a person’s inability to repair damage to the skin barrier. Staphylococcus aureus (SA) is a virulent pathogen that plays an important role in the progression of secondary infection in AE patients, thus intensifying the disease's virulence. In this study, the inhibitory activities of phytoconstituents from Azadirachta indica and Murraya koenigii against the SA (Protein Data Bank ID: 7TIO) using an in silico approach are presented. Site-specific docking analysis was carried out on the virulent pathogen with the docking center at X: 1.65044, Y: 1.7980, Z: 3.1878, …

Traittrainr: Accelerating Large-Scale Simulation Under Models Of Continuous Trait Evolution, Jenniffer Roa Lozano, Mataya Duncan, Duane D. Mckenna, Todd A. Castoe, Michael Degiorgio, Richard Adams

Entomology and Plant Pathology Faculty Publications and Presentations

Abstract

The scale and scope of comparative trait data are expanding at unprecedented rates, and recent advances in evolutionary modeling and simulation sometimes struggle to match this pace. Well-organized and flexible applications for conducting large-scale simulations of evolution hold promise in this context for understanding models and more so our ability to confidently estimate them with real trait data sampled from nature. Results

We introduce TraitTrainR, an R package designed to facilitate efficient, large-scale simulations under complex models of continuous trait evolution. TraitTrainR employs several output formats, supports popular trait data transformations, accommodates multi-trait evolution, and exhibits flexibility …

Breast Cancer: Her2-Mutant P53 Cooperation And The Cell-Of-Origin Dependent Dynamics, Abie Williams-Villalobo

Dissertations (2016-Present)

Subtype. Specifically, NCP172 and NCP245 tumors grew faster and were predominantly triple- negative than NCP245. RNA sequencing identified many differentially expressed genes (DEGs) between tumor and mammary gland controls. Ingenuity Pathway Analysis (IPA) of the DEGs revealed that pathways like Deubiquitination, Cell Cycle Checkpoints, RHO GTPase cycle, and HIF1α Signaling were associated with aggressive tumor characteristics, with heightened pathway activity in NCP172 likely contributing to greater growth and invasiveness.

This study further examined how different cells-of-origin contribute to breast cancer heterogeneity by inducing mutant p53 in either mammary myoepithelial or luminal cells. Tumors originating from myoepithelial cells (Tk5) exhibited …

The Impact Of E-Commerce On Digital Marketing Hopes And Ambitions: A Case Study In Airline Reservation Offices In Iraq, Anas Maaroof, Abdullah Oğrak

Journal of Economics and Administrative Sciences

Purpose: The current study aims to identify the impact of e-commerce with digital marketing in airline reservation offices in the Republic of Iraq. The study consists of two main variables: the independent variable that included e-commerce, which consisted of four dimensions: Business-to-Business, Consumer-to-Business, and Consumer-to. - Consumer, Business-to-Government, and the dependent variable represents digital marketing, the dimensions of which are: website design, social media marketing, search engine optimization, and email marketing. Theoretical Framework: Upon on Maaroof, A. (2021) This study highlights the importance of e-commerce and digital marketing, such as booking corners during digital transactions in airline reservation offices, as …

The Impact Of Talent Management Strategies On Organizational Ingenuity: An Empirical Research In Some Colleges Of The University Of Baghdad, Amal Mohammed Radhi, Adel Abd Al-Abbasi

Journal of Economics and Administrative Sciences

The main object of this research is to test the effect of talent management strategies on organizational ingenuity in several colleges of the University of Baghdad (College of Physical Education for Girls, College of Physical Education and Physical Sciences, Main College of Fine Arts, and the sub-college of fine arts). The research problem is that there is a dearth of studies examining how talent management techniques affect organizational ingenuity. The research adopted the descriptive analytical approach to study the phenomenon thoroughly. The questionnaire was the main tool for collecting data and information. The research sample included heads of academic departments, …

Polarimetry Terahertz Imaging Of Human Breast Cancer Surgical Specimens, Nikita Gurjar, Keith Bailey, Magda O. El-Shenawee

Electrical Engineering and Computer Science Faculty Publications and Presentations

Purpose

We investigate terahertz (THz) polarimetry imaging of seven human breast cancer surgical specimens. The goal is to enhance image contrast between adjacent tissue types of cancer, healthy collagen, and fat in excised breast tumors. Based on the biological perception of random growth of cancer and invasion of surrounding healthy tissues in the breast, we hypothesize that cancerous cells interact with the THz electric field in a different manner compared with healthy cells. This difference can be best captured using multiple polarizations instead of single polarization.

Approach

Time domain pulsed signals are experimentally collected from each pixel of the specimen …

Advocating For More Personalized And Evidence-Based Approaches In Dental Practice, Integrating Advanced Diagnostic Tools And Innovative Treatments To Enhance Patient Care, Hasanuddin, Acing H. Mude, Muhammad Ikbal, Erni Marlina, Muhammad Ruslin

Journal of Dentomaxillofacial Science

This editorial review highlights a series of studies emphasizing evident discoveries in the diagnosis and treatment of oral diseases. The first report addresses a rare case of unicystic ameloblastoma located in the maxillary sinus, highlighting the need of histological analysis for precise identification despite deceptive radiographic characteristics. A different example examines dentigerous cysts, highlighting diagnostic problems stemming from unusual appearances, finally clarified by histological assessment. The effectiveness of sclerotherapy with hypertonic saline for treating parotid sialocele is examined, indicating it as a safe and efficacious therapeutic alternative. The influence of anemia on pediatric drug-induced erythema multiforme is examined, highlighting the …

Potential Ethanol Extracts Of Super Red Dragon Fruit Peel And Flesh For Detecting Dental Plaque, Euis R. Yuslianti, Dewi Li. Nasution, Nadya S. Pramita

Journal of Dentomaxillofacial Science

Objective: Dental plaque is a collection of microorganisms that adhere to surface of tooth and can cause various health problems in oral cavity. To detect plaque on surface of teeth, a coloring agent such as a disclosing solution is needed. As an alternative ingredient that does not harm, this study used super red dragon fruit peel and flesh (Hylocereus costaricensis) which is high levels of anthocyanins and natural coloring agents that can be used as alternative materials for detecting plaque on surface of tooth.

Material and Methods: The research methode were quasi-experimental design research with a post-test control …

Chitosan Black Soldier Fly (Hermetia Illucens) Pupae Can Improve Macrophages And Fibroblast Post-Extraction Teeth, Renie K. Dewi, Sri Oktawati, Asdar Gani, Eko Suhartono, Zakiah H. Noor, Nurlindah Hamrun, Shahida M. Said, Beta W. Oktiani

Journal of Dentomaxillofacial Science

Objective. The objective of this study was to quantify the number of macrophages and fibroblasts involved in the post dental extraction socket healing.

Material and Methods. Chitosan BSF pupae was made into a gel preparation. Eighteen Male Cavia cobaya were divided into two groups (n = 9), control and treatment groups. BSF pupae chitosan gel was applied to the post-extraction tooth socket in the treatment group, while none was applied to the control group. The samples were decapitated on the 2^nd, 3^rd, and 5^th days by cutting the mandibular bone for histopathological examination, which was …

Sedimentary Characteristics Of Flood Deposits In Coastal And Fluvial Environments: Examples From Washover Fans (North Carolina, Usa) And Floodplain Deposits (Mississippi, Usa), Shara Gremillion

Dissertations

Extreme flooding from severe and prolonged meteorological events and / or overbanking rivers are some of the most deadly and expensive disasters globally, impacting millions of lives, the environment, and property. People living in vulnerable areas, such as near coasts and rivers, are the first to be impacted with effects of these flood hazards. Scientific studies and their results can aid communities and officials in planning and preparing for those flood impacts. In this three-part study, flood impacts from coastal storms in North Carolina, and flooding along the Mississippi River (MSR) in the state of Mississippi, USA are assessed from …

Apoa2 Increases Cholesterol Efflux Capacity To Plasma Hdl By Displacing The C-Terminus Of Resident Apoa1, Snigdha Sarkar, Jamie Morris, Youngki You, Hannah Sexmith, Scott E. Street, Stephanie M. Thibert, Isaac K. Attah, Chelsea M. Hutchinson Bunch, Irina V. Novikova, James E. Evans, Amy S. Shah, Scott M. Gordon, Jere P. Segrest, Karin E. Bornfeldt, Tomas Vaisar, Jay W. Heinecke, W. Sean Davidson, John T. Melchior

Saha Cardiovascular Research Center Faculty Publications

Abstract The ability of high-density lipoprotein (HDL) to promote cellular cholesterol efflux is a more robust predictor of cardiovascular disease protection than HDL-cholesterol levels in plasma. Previously, we found that lipidated HDL containing both apolipoprotein A-I (APOA1) and A-II (APOA2) promotes cholesterol efflux via the ATP-binding cassette transporter (ABCA1). In the current study, we directly added purified, lipid-free APOA2 to human plasma and found a dose-dependent increase in whole plasma cholesterol efflux capacity. APOA2 likewise increased the cholesterol efflux capacity of isolated HDL with the maximum effect occurring when equal masses of APOA1 and APOA2 coexisted on the particles. Follow-up …

Untargeted Lipidomics Reveals Novel Hdl Metabotypes And Lipid-Clinical Correlates, Peer W. F. Karmaus, Scott M. Gordon, Marcus Y. Chen, Alison A. Motsinger-Reif, Rodney W. Snyder, Timothy R. Fennell, Suramya Waidyanatha, Reshan A. Fernando, Alan T. Remaley, Michael B. Fessler

Saha Cardiovascular Research Center Faculty Publications

Plasma high-density lipoprotein (HDL), originally studied for its role in lipid transport, is now appreciated to have wide-ranging biological functions that become defective during disease. While >200 lipids have collectively been detected in HDL, published HDL lipidomic analyses in different diseases have commonly been targeted to prespecified subsets of lipids. Here, we report the results of untargeted lipidomic analysis of HDL isolated from 101 subjects referred for computed tomographic coronary imaging for whom multiple additional clinical and lipoprotein metadata were measured. Unsupervised clustering of the total HDL lipidome revealed that the subjects fell into one of two discrete groups, herein …

Differentiating Mycosis Fungoides Lesions From Their Mimickers Clinically And Histologically: A Single Tertiary Center Retrospective Analysis In Saudi Arabia, Fatimah M. Budair, Ahmed A. Alsayyah, Omar M. Alakloby

Saudi Medical Journal

Objectives: To identify the clinical and histological features of MF that can assist in distinguishing MF from MF-mimicking cases. Although mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma, clinicopathological correlations are required to establish an accurate diagnosis, which are currently lacking. Methods: This retrospective observational study evaluated the clinical presentations, characteristics, and histological features of 56 patients with suspected MF who presented to our clinic between January 2018 and August 2022. Immunohistochemistry was performed, and the loss of CD5 and CD7 T-cells and T-cell receptor rearrangement was evaluated. Results: Overall, 34 patients were diagnosed with MF, …

Influence Of Head Sway On The Availability Of Visual Information In An Affordance Task, Ron Dickson Jr.

Honors Theses

This thesis investigated how varying postural conditions and environmental challenges influence human affordance perception in virtual environments, focusing specifically on participants’ judgments about whether they could stand upright on sloped surfaces. Using virtual reality (VR) to simulate ramps at various inclines, participants assessed their ability to stand on these slopes under different postural constraints (unaided standing, leaning, and touch-supported). Data was collected on head movement dynamics, including movement magnitude, variability, and complexity, using measures such as Euclidean distance and effort-to-compress (ETC). Logistic and linear regression analyses revealed that slope angle and stance significantly impacted participants' affordance judgments and movement patterns, …

A Linguistic Analysis Of The Language Surrounding Witchcraft In France From The 16th To 20th Centuries, Kaleigh Landers

Honors Theses

While the history of witchcraft in France is a subject that has received significant scholarly attention, little research has been conducted on the linguistic implications of the language used in regard to the subject. This study attempts to analyze the texts written about witchcraft between the 16^th and 20^th centuries in order to draw conclusions as to how language and culture affect each other. The aim of this study was to conduct a discourse analysis of these texts to identify cultural connotations, language trends, and insights regarding how the French language has evolved to communicate complex, dividing concepts …

Water Fluoridation: The Evidence Behind The Risk Of Fluoride Use, Margherita Fontana D.D.S., Ph.D., Carlos González-Cabezas D.D.S., M.S.D., Ph.D., Livia Tenuta D.D.S., M.Sc., Ph.D.

The Journal of the Michigan Dental Association

The debate surrounding fluoride use for caries control has intensified due to recent events, including a National Toxicology Program (NTP) report and a court ruling mandating EPA action on fluoride levels in tap water.

Despite concerns about fluoride's potential neurodevelopmental impact at high concentrations, current evidence shows no adverse effects at the recommended levels of 0.7 ppm in U.S. community water fluoridation programs. While studies in regions with endemic fluorosis suggest an association between high fluoride exposure and lower IQ, methodological limitations undermine causal conclusions.

Global and U.S. health authorities, including the WHO and ADA, reaffirm the safety and efficacy …

Vavanga, Vavalo, And Fakakaukau With Vā-Tā, Siosiua F.P. Lafitani

Pacific Studies

This article addresses the profound cognitive and cultural significance of vavanga (contemplation) and vavalo (contemplation), which are contempla- tive frameworks deeply rooted in the concept of vā (space) within Tongan language and culture. These frameworks serve as gateways to expansive cogni- tive exploration, stretching the boundaries of imagination and contemplation. Fakakaukau (thinking), double or dual actor (named because it bridges the realms of cognition and practicality), uses instrumental concepts such as fifili (inquisitiveness) and fekeli (meticulous exploration) to navigate the landscapes of inquiry. Throughout this exploration, a critical distinction emerges between tā as tempo and the cognitive concepts of contemplation …

Modeling Instrument Design Risks In Medical Device Reprocessing, Manuel Andres Gutierrez

All Dissertations

Medical device reprocessing is an essential practice in healthcare delivery. While FDA regulations require device manufacturers to develop and validate reprocessing procedures, the increasing complexity of medical device designs and their use environments can increase the risks of inadequate reprocessing and associated device malfunctions and potential patient injury. While some design features present known difficulties for reprocessing, critical information needed to define relative risks or feature-specific parameters that increase or decrease risks of inadequate reprocessing is lacking. There is an urgent need for tools to quantify and predict reprocessing risks associated with design features used in surgical instruments.

The broad …

Deformation Mechanism In Gold Nanoparticles Under Compressive Loading: Insights From Atomistic Modelling And Unsupervised Machine Learning, Tanuj Gupta

All Dissertations

Gold nanoparticles (AuNPs) offer exciting possibilities due to their inertness, malleability, and tunable structures, making them valuable for applications ranging from nanomedicine to electronics. Their optical, mechanical, and other properties can be tailored by modifying shape and structure, underscoring the importance of understanding their deformation behaviour at the nanoscale. This study used classical molecular dynamics simulations with LAMMPS to investigate the deformation mechanisms of gold nanospheres (AuNS) under uniaxial compression. Employing the embedded atom method (EAM) potential to model atomic interactions, AuNS with 20 nm in diameter were compressed along the z-direction using planar indenters moving at a constant …