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Host Response To Implantation Of A Poly N-Isopropylarylamide Injectable Cell Therapy Vehicle, Cole Matthew Burk

Master's Theses

There is a need to develop novel and effective therapies targeting end-stage peripheral arterial occlusive disease (PAOD). Inducing collateral arteriogenesis is a possible novel treatment that produces a natural bypass for blood flow, a promising solution to the long-term issues seen with current treatments. Regenerative therapies, and progenitor cells specifically, have demonstrated great promise in repair after injury and disease. While most progenitor or stem cells have poor efficacy in this context, muscle progenitor cells, or myoblasts, have encouraging results. Myoblasts enhance arteriogenesis and secrete cytokines or chemokines that recruit monocytes to injury sites. Implanting these adherent cells in a …

Fat Deposition, Β- Carotene, And Vitamin A Metabolism In Bulls, Steers, And Heifers, Tesla Trammell

Masters Theses & Specialist Projects

Research highlights the impact of Vitamin A on cattle growth and meat quality. Supplementing Vitamin A early in life has been linked to enhanced IMF content and growth rates in calves, especially when administered at birth or during early developmental stages. This is attributed to the role of the ZFP423 gene in adipocyte formation, with studies noting its involvement in the development of IMF during the finishing phase.

This study aims to add to the present research by evaluate the effect of calves’ sexual class on blood β-carotene and Vitamin A before weaning. The second study evaluated the β- carotene …

Subconcussive Impacts And Their Effect On Attention, Scott York

Masters Theses & Specialist Projects

In recent years, concussions have become a focal point for athletic competition and athletes beginning in grade school. The long-term implications of concussions are becoming more widely known and accepted; however, there are still areas of literature that are lacking. One of these areas is subconcussive impacts. Subconcussive impacts are defined as impacts that do not meet the threshold for diagnosed concussion but may still have clinical impact. While concussions and their effects on cognition have been examined heavily, these subconcussive impacts, and their effects, have been studied less so. The purpose of this study is to examine the possible …

(R2095) On Discrete Hypoexponential Distribution And Integer-Valued Autoregressive Process, K. Krishnakumari, Dais George

Applications and Applied Mathematics: An International Journal (AAM)

Discrete distributions provide a substantive contribution in modeling real world frame work. Though a lot of discrete distributions are available in literature, they are inappropriate to model many practical situations. The conventional discrete distributions like geometric, Negative Binomial and Poisson have limited applications in modeling count and lifetime data. This paper introduces a new two parameter discrete distribution namely, discrete hypoexponential distribution by discretizing the well known hypoexponential distribution. Various distributional and structural properties of the proposed distribution are studied. We introduce a first order auto regressive process with the newly proposed distribution as marginal and study the properties. Depending …

(R2108) Global Asymptotic Stability Analysis Of Discrete Time Population Model With Allee Effect Through Lyapunov Function, Govind Jha, Neeraj Kumar, Sarita Jha

Applications and Applied Mathematics: An International Journal (AAM)

This study explores the idea of stability analysis by using Lyapunov functions in discrete time population models; this work focuses on the nth generation. Further, this investigation aims to extend global stability concepts to discrete-time models and considers the influence of the Allee effect on population dynamics. Mathematical formulations and specific modelling approaches are utilized to investigate the behavior of the population system. The results reveal a larger range of stability in comparison to previous findings, emphasizing the effectiveness of the Lyapunov function approach. Specifically highlighted here are the extension of global stability concepts to the nth generation providing insights …

(R2099) Boundedness And Square Integrability In Neutral Differential Equations With Delay And Exponential Stability In Nonlinear Differential Equations Of Third-Order, Fatima Abdellaoui, Mebrouk Rahmane

Applications and Applied Mathematics: An International Journal (AAM)

The Lyapunov second method is an eigenvalue-based technique which consist of finding a Lyapunov function candidate for studying the stability of dynamical systems which is hard to deal with especially in most of nonlinear cases. Studying the stability and some of other qualitative behaviors based on the Lyapunov second method is research topic of actuality because of the wide range of applications of the differential equations. Many authors in the literature have used the second method of Lyapunov in the study of some qualitative behaviors from which the stability, the boundedness and the square integrability of solutions for various kinds …

Design And Testing Of A Prototype Prosthesis For Pediatric Upper-Limb Transradial Amputees To Provide Adjustable Size And Modular Characteristics, Paul Heli

Master's Theses

This study was conducted to develop a financially accessible body-powered upper-limb prosthetic socket that can be adjusted to maintain fit and function for a growing child with a transradial amputation. The main objectives of the study were to design, manufacture, and test a device that was comfortable, functional, affordable, and adjustable. The socket was designed to be comfortable using global variables controlling the computer-aided design (CAD) model size with user-specific measurements. Comfort was also incorporated using shape-forming of the socket for specific residual limb features. The device was designed to perform the two main functions of suspension, or attachment to …

The Price Of Precision: Significant Figures And The Student Experience, Ryan Michael Britt

Dissertations

For students pursuing careers in medicine and science, general chemistry is often viewed as a gatekeeper course. Students struggle with general chemistry for a variety of reasons, one of the most common being mathematical difficulties. Compared to other lower division STEM courses, mathematical computation in general chemistry represents a unique challenge for the student due to the special emphasis placed on reporting answers to the proper degree of precision using significant figure (SF) rules. Although these rules feature in nearly every undergraduate chemistry course, their impact on the student experience of learning chemistry has never before been studied.

The purpose …

The Australian Experience With Environmental Offsets: An Illusory Tool For Addressing Biodiversity Loss And Climate Change?, Robert J. Fowler, Phillipa C. Mccormack, Alexandra S. Wawryk, Margaret Castles, Emily Whenan

UC Law Environmental Journal

Recent studies, including by administrative integrity bodies, Parliamentary committees and former ‘insiders’ of Australian regulatory bodies, show serious shortcomings in the operation of biodiversity and carbon offsets in Australia. Specifically, the benefits attributed to the offset mechanism in both contexts have been criticised as illusory in practice. This leads us to question whether it is possible to accomplish carbon emission reduction and biodiversity conservation goals through a governance framework that includes offsetting. We assess the evolution of offsets as a regulatory and voluntary mechanism, offering a critical perspective on the Australian experience. Australia has been an enthusiastic early adopter of …

Neuronal And Glial Cell Alterations Involved In The Retinal Degeneration Of The Familial Dysautonomia Optic Neuropathy, Anastasia Schultz, Henar Albertos-Arranz, Xavier Sánchez Sáez, Jamie Morgan, Diane Darland, Alejandra Gonzalez-Duarte, Horacio Kaufmann, Carlos E. Mendoza-Santiesteban, Nicolás Cuenca, Frances Lefcort

Biology Faculty Publications

Familial dysautonomia (FD) is a rare genetic neurodevelopmental and neurodegenerative disorder. In addition to the autonomic and peripheral sensory neuropathies that challenge patient survival, one of the most debilitating symptoms affecting patients' quality of life is progressive blindness resulting from the steady loss of retinal ganglion cells (RGCs).Within the FD community, there is a concerted effort to develop treatments to prevent the loss of RGCs. However, the mechanisms underlying the death of RGCs are not well understood. To study the mechanisms underlying RGC death, Pax6-cre;Elp1loxp/loxp male and female mice and postmortem retinal tissue from an FD patient were used to …

Early Referral For Eye Movement Desensitization And Reprocessing Therapy For Treatment Of Trauma-Induced Anxiety And Emotional Distress, Christa Jones

Doctoral Projects

Trauma, anxiety, and emotional distress are significant health concerns affecting millions globally and resulting in significant healthcare burdens. Despite the considerable efforts in addressing problems, most high-risk cases often go unidentified or unaddressed promptly. Besides standard trauma diagnosis, treatment, and management protocols, some patients often require specialized support. Recently, Eye Movement Desensitization and Reprocessing (EMDR) has emerged as a promising alternative for treating anxiety, trauma, and emotional distress conditions, yet many patients who are at high risk are often not identified early for referral. Additionally, many healthcare facilities, especially those in rural settings, fail to include appropriate screening tools.

This …

Prescription For Change: Tackling Inappropriate Antibiotic Use In Urgent Care Settings, Lachundra Mosley

Doctoral Projects

A pressing global health issue that significantly contributes to antibiotic resistance is the inappropriate antibiotic prescribing for Upper Respiratory Infections (URI’s) in urgent care settings (World Health Organization [WHO], 2022). The purpose of this doctoral project was to reduce inappropriate antibiotic prescriptions for URI at an urgent care in D’Iberville, Mississippi through the implementation of an educational pamphlet.

A pre-post intervention project was conducted, collecting data on antibiotic prescribing practices via retrospective chart reviews before and after the educational intervention. Data was collected using a researcher developed screening tool based on Evidence based guidelines to distinguish viral vs bacterial infections. …

Bioindicators Of Mercury In Riverine Systems, Kathryn Mudica

All-Inclusive List of Electronic Theses and Dissertations

This study focuses on the bioaccumulation and biomagnification of mercury in freshwater food webs, with emphasis on bioindicators, such as macroinvertebrates, crayfish, and river otters. Despite regulatory efforts and advancements in monitoring, significant gaps remain in understanding mercury dynamics in freshwater systems—especially regarding its transport, methylation, and bioavailability across different ecosystems. To address these knowledge gaps, this study adopts a biocentric approach, emphasizing the role of living organisms in their environment. By utilizing macroinvertebrates, crayfish, and river otters as bioindicators, we aim to assess mercury bioavailability and distribution. These organisms provide varying temporal and spatial scales of mercury accumulation, offering …

Why Am I The Only Black Student? An Examination Of The Expected Level Of Engagement At Indiana Universities For High Achieving African American Students Based On Precollege Factors, Zoretta Ward-Holloway

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study is to investigate the individual and school level precollege factors, including student engagement levels, associated with high achieving African American graduates of varied high school types to ascertain whether a relationship/pattern emerges that provides a profile and helps to explain the interactions between multiple levels of ecological factors that impact academic success in high school and expected level of engagement in college. The Beginning College Survey of Student Engagement (BCSSE) instrument was used to consider self-reporting archival data of high-performing African American students as a means of gathering the voices of students. BCSSE instruments from …

Land Cover Effects On Stream Water Chemistry In The Upper Saline River Watershed, Brandy Everett

Graduate Theses and Dissertations

Non-point source (NPS) pollutants and the conversion of natural areas to anthropogenic uses are one of the most critical stressors on water quality. The Upper Saline River Watershed has seen an increase in anthropogenic land cover over the last two decades, leading it to be previously identified as a 319 NPS priority watershed in Arkansas. This study used publicly available data to assess the magnitude and trends of total nutrients (TN and TP) at both the watershed and site level scale. Results suggest a decrease of 2.6%/yr in TN concentrations and 1.5%/yr in TP concentrations at the watershed scale. While …

Advanced Numerical Techniques For Multiscale Simulations In Biofluid Dynamics, Justin Tamico Jack

Graduate Theses and Dissertations

The study of anisometric particle suspensions and congenital heart defects (CHDs) involve exploring complex phenomena within the biological sciences. The former subject dives into the phase behavior of liquid crystals (LCs), particularly the influence of the shape anisotropy of rod-like nanoparticles on phase transitions, through the implementation of statistical techniques involving molecular dynamics (MD). Conversely, the latter topic focuses on the assessment and management of severe congenital arterial stenoses, such as those found in Williams-Beuren syndrome (WS), through advanced multi-scale computational fluid dynamics (CFD) simulations. Both areas emphasize the importance of detailed analysis and the use of advanced numerical modeling …

List Of Open Resources Used By Cycle 5 Unc Grantees, Nancy A. Henke

Open Course Materials

No abstract provided.

Evidence Of Capacity Building And Critical Consciousness In An Institutional Partnership: An Organizational Case Study Of The Gateway Research Park, Natasha E. Johnson

All-Inclusive List of Electronic Theses and Dissertations

Higher education institutions (HEIs) are complex and intricate systems of people, processes, and practices. HEI practices and processes are often extended through strategic partnerships and external collaborations, increasing their capacity or ability to obtain their stated goals. This notion extends to minority-serving institutions, including Historically Black Colleges and Universities. It is important to understand whether partnerships have the capacity to meet their goals, especially if there are risks for minority-serving institutions and those traditionally marginalized, which is a problem. The purpose of this qualitative organizational case study was to explore the evidence of critical consciousness and capacity building in a …

A Framework For Sharing Of Clinical And Genetic Data For Precision Medicine Applications., Ahmed Elhussein, Ulugbek Baymuradov, Nygc Als Consortium, Noémie Elhadad, Karthik Natarajan, Gamze Gürsoy

Faculty Research 2024

Precision medicine has the potential to provide more accurate diagnosis, appropriate treatment and timely prevention strategies by considering patients' biological makeup. However, this cannot be realized without integrating clinical and omics data in a data-sharing framework that achieves large sample sizes. Systems that integrate clinical and genetic data from multiple sources are scarce due to their distinct data types, interoperability, security and data ownership issues. Here we present a secure framework that allows immutable storage, querying and analysis of clinical and genetic data using blockchain technology. Our platform allows clinical and genetic data to be harmonized by combining them under …

Aged 539 Graduate Internship Report - Buhach Colony High School, Shad M. Menezes

Agricultural Education: Graduate Internship Reports

This report documents the implementation and outcomes of a comprehensive agricultural education program at Buhach Colony High School, aligning with California Career Technical Education (CTE) standards. The project focuses on enhancing student engagement through curriculum development, leadership activities, Supervised Agricultural Experiences (SAEs), and career readiness initiatives. Key components include expanding pathway offerings in horticulture, mechanics, and agricultural sciences, integrating field experiences, and hosting guest speakers to connect students with industry professionals.

Microwave Flow Cytometer For Single Cell Detection, Differentiation, And Drug Effect Study, Neelima Dahal

All Dissertations

New methods to rapidly detect and identify pathogens in patients’ blood are needed for timely disease treatment. In this work, a tunable microwave interferometer was used to measure single Candida cells of C. albicans, C. tropicalis, C. parapsilosis, and C. krusei at multiple frequencies between 0.265 GHz and 7.76 GHz. A Quadratic Discriminate Analysis was used to classify Candida species with an accuracy of 0.875. Likewise, a microwave device was used to measure single Escherichia coli cells of B and K-12 strains at multiple frequencies between 500 MHz and 8 GHz. A LightGBM model was developed to …

Electrochemical Techniques For The Treatment Of Source-Separated Urine, Philip Arve

All Dissertations

Urine makes up approximately 1% of the total volume of municipal wastewater, but it contributes up to 75% of the nitrogen and 50% of the phosphorus received by publicly owned treatment works (POTWs). These elements are essential nutrients for plant growth and trigger algal blooms when released into natural bodies of water, resulting in rapid ecological degradation. Removing these nutrients from municipal wastewater is energy intensive and often operationally sensitive. The past few decades have seen an increase in focus on the source-separation and side-stream treatment of urine.

Urine characteristics differ greatly from those of municipal wastewater, presenting an opportunity …

The Mongolian Remodeling And The Structure Of Anoplocephalid Cestode Diversity, Mackenzie Grover

All NMU Master's Theses

Ecological disruption plays an important role in structuring diversity of flora, fauna, and their parasites. At the end of the Eocene, climatic change across Asia resulted in a faunal turnover (the Mongolian Remodeling) as rodents diversified and larger mammals declined. Throughout the Oligocene, the landscape in Asia was characterized by episodic climatic and landscape changes resulting in pulses of rodent diversification. The role of historical ecological disruption in Central Asia in structuring the diversity of parasites of small rodents has not been thoroughly investigated. The hyper-diverse Paranoplocephala species complex (family: Anoplocephalidae) infect rodents throughout the Holarctic and present an opportunity …

Investigating Impacts Of The Mycothiazole Chemotype As A Chemical Probe For The Study Of Mitochondrial Function And Aging., Naibedya Dutta, Joe A Gerke, Sofia F. Odron, Joseph D. Morris, Adam Hruby, Juri Kim, Toni Castro Torres, Sarah J. Shemtov, Jacqueline G. Clarke, Michelle C. Chang, Hooriya Shaghasi, Marissa N. Ray, Maxim Averbukh, Sally Hoang, Maria Oorloff, Athena Alcala, Matthew Vega, Hemal H Mehta, Max A Thorwald, Phillip Crews, Marc Vermulst, Gilberto Garcia, Tyler A. Johnson, Ryo Higuchi-Sanabria

Natural Sciences and Mathematics | Faculty Scholarship

Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective chemical probes based on their high efficiency to inhibit ETC complex I function. Similar to rotenone (Rote), MTZ, a newly employed ETC complex I inhibitor, exhibited higher cytotoxicity against cancer cell lines compared to certain non-cancer cell lines. Interestingly, 8-OAc demonstrated greater selectivity for cancer cells …

Aged 539 Graduate Internship Report - Live Oak High School, Savannah L. Burnett

Agricultural Education: Graduate Internship Reports

This report documents the implementation and outcomes of a comprehensive agricultural education program at Live Oak High School, aligning with California Career Technical Education (CTE) standards. The project focuses on enhancing student engagement through curriculum development, leadership activities, Supervised Agricultural Experiences (SAEs), and career readiness initiatives. Key components include expanding pathway offerings in horticulture, mechanics, and agricultural sciences, integrating field experiences, and hosting guest speakers to connect students with industry professionals.

Impact Of Irrigation Systems On Water Use And Water Productivity: A Case Study Using Aquacrop In Khartoum, Sudan, Abdalhakam Almagzoop

Department of Agricultural and Biological Systems Engineering: Masters Project Reports

Water scarcity significantly challenges agricultural productivity in arid regions like Khartoum, Sudan. This study evaluates the impact of three irrigation systems—furrow, sprinkler, and surface drip—on the water use and productivity of sorghum (Sorghum bicolor L.) under different climatic conditions using the AquaCrop model. Simulations were conducted for three representative years: a wet year (2022), a normal year (2015), and a dry year (2018). The results demonstrate that irrigation substantially improved water use efficiency and crop yield compared to non-irrigated (rainfed) conditions. Rainfed crops resulted in lower biomass, harvest index, and yield, particularly in the dry year, highlighting the importance …

Enhancing Water Sustainability In North Africa: Literature Review And Synthesis Of Current Knowledge Gaps In Sudan, Osman M. A. Adam

Department of Agricultural and Biological Systems Engineering: Masters Project Reports

This study delves into the critical role of groundwater in addressing global water challenges, with a focus on the Nubian Sandstone Aquifer System (NSAS) in north Africa. Groundwater constitutes a source of potable water, irrigation, and industrial use, especially in arid regions where surface water is limited. We analyzed the status of water quantity, withdrawals, recharge, and geological characteristics in the NSAS, specifically in Sudan, Egypt, and Libya. Though the NSAS is largely an untapped resource, water withdrawals from the NSAS in Egypt, Sudan, and Libya are projected to increase substantially from 2000 to 2100 due to population growth, with …

Clemson Commencement Program, December 2024, Clemson University

Clemson Commencement Programs

No abstract provided.

Wofford Today Winter 2024, Wofford College. Office Of Marketing And Communications

Wofford Today

No abstract provided.

Elucidating The Mechanism Of Interleukin-17a Signaling In The Pathogenesis Of West Nile Virus, Farzana Nazneen

Dissertations

West Nile Virus (WNV), a neurotropic flavivirus transmitted by mosquitoes, is a leading cause of viral encephalitis in the United States and remains a significant public health concern. Unfortunately, no vaccine or therapeutic intervention is available against WNV infection. Previous studies, including ours, demonstrated that interleukin-17A (IL-17A) signaling increases the cytotoxic potential of CD8⁺ T cells to facilitate WNV and parasite clearance; however, the molecular mechanism is not understood. IL-17 receptor C (IL-17RC) is an obligatory co-receptor with IL-17 receptor A (IL-17RA) for signaling induced by IL-17A, IL-17A/F, and IL-17F. In this study, we found that IL-17RC deficient ( …