Digital Commons Network^™

Advanced Techniques In Time Series Forecasting: From Deterministic Models To Deep Learning, Xue Bai

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation discusses three instances of temporal prediction, applied to population dynamics and deep learning.

In population modeling, dynamic processes are frequently represented by systems of differential equations, allowing for the analysis of various phenomena. The first application explores modeling cloned hematopoiesis in chronic myeloid leukemia (CML) via a nonlinear system of differential equations. By tracking the evolution of different cell compartments, including cycling and quiescent stem cells, progenitor cells, differentiated cells, and terminally differentiated cells, the model captures the transition from normal hematopoiesis to the chronic and accelerated-acute phases of CML. Three distinct non-zero steady states are identified, representing …

Investigation Of Synergistic Effect Between Polystyrene And Polyethylene Under Conventional Thermal Heating And Microwave Heating, Thang Luong

Graduate Theses, Dissertations, and Problem Reports (ETD)

Single-use plastics (Low Density Polyethylene, LDPE; Polystyrene, PS; Polypropylene, PP) are increasingly used in the modern world, with their usage growing every year. An effective method to manage the resulting waste is urgently needed, as landfilling and incineration have proven harmful to the environment in the long term. Mechanical recycling may not maintain the desirable characteristics of the single-use plastics through several cycles. Pyrolysis emerges as a promising approach to address plastic waste. Given that single-use plastic waste often comes in a mixture, combining plastic in the feedstock is a viable solution to effectively convert these polymers altogether to gain …

Love And Solitude In Latin America: An Actor’S Take, Performing Graciela In Diatriba De Amor Para Un Hombre Sentado By Gabriel Garcia Marquez, Claudia C. Sevilla

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this thesis I take a journey through twentieth century Latin America through inhabiting the role of Graciela created by the late great Gabriel Garcia Marquez in his only work of theatre. Through detailed historical research I explore human topics such as marriage and isolation embodied in Graciela that in a sense mirror a people and a continent. The challenges of producing a play with no budget or partners and the freedoms and constraints of performing a one-person show, which included an audience that does not speak the language the play is written in. How does an actor adapt to …

Personalized Molecular Therapies For Advanced Non-Small Cell Lung Cancer: Overcoming Heterogeneity To Optimize Treatment Response And Clinical Outcomes, Zuan-Fu Lim

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lung cancer remains one of the deadliest cancers. Novel, paradigm shifting treatments including immunotherapy and targeted therapies have recently been developed to cull the deadly effects of lung cancer, but many challenges remain. There remains a significant unmet need to accurately predict and optimally select for patients who will respond to immune checkpoint inhibitors (ICI) treatment. In Chapter 2 of this dissertation, we investigated a novel live single cell cytokine profiling lab-on-chip platform, IsoLight, using peripheral CD4+ and CD8+ T-cells for ICI biomarker development. A total of 55,175 single T-lymphocytes were analyzed in this proof-of-concept study. We found that an …

Political Agency In The Occupied House: Reconstructing Memory Through Squatter Resilience At Topf And Sons Historical Museum, Ebony Taylor Martin

Graduate Theses, Dissertations, and Problem Reports (ETD)

During the Holocaust the company of J.A Topf and Sons refocused their production to produce and improve a design for corpse incineration ovens. Their contributions streamlined the efficiency and performance of the death camps adding to the mounting death toll. Years after these evens the company grounds were abandoned and then given life again by a leftist youth movement. The squatter’s reinterpreted the history, led tours and utilized the grounds to create a third place for community, art and music. When the city decided to recognize the history of the company, the squatters were forcefully removed, and the building transformed …

Autonomous Object Search Planning In Large-Scale Environments, Matthew A. Collins

Graduate Theses, Dissertations, and Problem Reports (ETD)

The advancement of autonomous search holds significant promise for applications ranging from emergency response to planetary exploration. This thesis investigates strategies to enhance autonomous search performance in large-scale environments. The main contribution of this work is its practical application in real-world scenarios, where efficient search methods are essential for managing vast amounts of data, particularly in large environments. Effective search planning requires navigating complexities such as limited prior information and managing large state spaces, necessitating advanced strategies to plan with this limited information. Additionally, balancing exploration and exploitation is crucial for optimizing the search process, as it ensures thorough coverage …

Changes In Psychiatric Diagnosis Associated With Sars-Cov-2 Infection And Predicting The Development Of New Psychiatric Illness In Covid Patients By Using Machine Learning Approach: A Study Using The Us National Covid Cohort Collaborative (N3c), Asif Rahman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The enduring impact of COVID-19 extends beyond acute illness, with potential long-term psychiatric consequences raising significant concern among healthcare professionals and researchers alike. Emerging evidence suggests a multifaceted relationship between COVID-19 and the development of different psychiatric illnesses like Schizophrenia Spectrum and Psychotic Disorders (SSPD), Depression, Bipolar disorder, Personality disorder, Trauma, and a range of other mental health conditions. Considering these emerging connections, our study endeavors to rigorously assess the associations between COVID-19 and various psychiatric illnesses while simultaneously employing machine learning techniques to predict the development of new psychiatric disorders in individuals affected by the virus. Leveraging the extensive …

Breaking The Silence: International Students’ Communication About Sexual Assault And Opportunities For Improved Prevention Messaging, Samaha Ghani

Graduate Theses, Dissertations, and Problem Reports (ETD)

The beginning of college campus life is one of the most exciting phases of student life. However, for some students, it might pose a threat in the form of sexual violence. In the United States, sexual violence is highly pervasive, placing college students at a greater risk of victimization. Currently, there is a lack of data on sexual crimes within the international student population on U.S. college campuses due to cultural and language barriers. As such, the purpose of this study is to explore international students’ communication needs around the topic of sexual consent and sexual violence. This vulnerable and …

A Domain Adaptation Approach For Morphology-Independent Cell Instance Segmentation, Voke Rotimi Brume

Graduate Theses, Dissertations, and Problem Reports (ETD)

In recent years, there has been an upward trend of utilizing deep learning to automate cell segmentation processes. As global storage capacities grow exponentially, so have microscopy data collections become larger and more frequent. To benefit from them, accurate and precise quantitative analysis tools like cell instance segmentation have become necessary. However, the highly variable nature of these data collections necessitates retraining segmentation models to maintain high accuracy on new data collections. This process is time-consuming and labor-intensive since a user must annotate much of the new data, usually under the supervision of a medical professional. The problem is further …

The Identification And Characterization Of Novel And Improved Antigens For Next-Generation Pertussis Vaccines, Gage Michael Pyles

Graduate Theses, Dissertations, and Problem Reports (ETD)

Whooping cough, or pertussis, is a highly infectious respiratory disease caused by infection with the Gram-negative bacterial pathogen Bordetella pertussis. Pertussis affects all age groups and populations; however, it is most severe in infants who are too young to receive vaccinations and remains a global health concern with more than­­­­ 200,000 cases reported globally in 2023. Vaccines against pertussis have been available in the United States since the 1940’s with the development and widespread use of whole cell pertussis vaccines. Following their introduction, the incidence of pertussis was controlled and limited to fewer than 5,000 cases per year. Despite …

Beccaria, The Executioner, And The French Revolution, Willa Carlyle Reising

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis explores ideas and practices in the French penal system during the Revolutionary era, especially during the Reign of Terror, considering the experiences of Revolutionary leaders and the executioner of Paris during the Revolution. It argues that while in some ways Revolutionary leaders used Enlightenment penal laws to justify their actions during the Reign of Terror, in other ways the Reign of Terror was a departure from Enlightenment penal reform laws. The main Enlightenment penal reformer which this thesis uses is Cesare Beccaria because he was influential in France and during the French Revolution in helping to create early …

Endogenous Glucocorticoid Signaling Is Required For Normal Macrophage Response To H. Pylori Infection, Stuti Khadka

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gastric cancer is the fifth leading cause of cancer-related deaths worldwide, affecting millions of people. H. pylori is the strongest risk factor for gastric cancer, with about 90% of the cases strongly associated with H. pylori infection. Half of the world's population is infected with this bacterium. However, only a small subset of the infected population (1-3 %) go on to develop gastric cancer. Diagnosis of the disease at an early stage is the biggest challenge because of the widespread prevalence of H. pylori infection and a long asymptomatic phase before the advanced stages. Patients are left with limited treatment …

Dynamic Exchange-Correlation Functional For Bandgap Optimization: Reparametrization And Machine Learning, Viviana Faride Dovale Farelo

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores predicting the physical properties of solids using first-principles methods, with a focus on Density Functional Theory (DFT). DFT uses the electronic density within a material to predict its properties, simplifying the treatment of electron-electron interactions and allowing the study of realistic systems with a balanced treatment between accuracy and computational efficiency. Additionally, machine learning (ML) is employed to create correlations between some physical properties of solids and other properties or parameters that are more difficult to calculate.

The main problem addressed in this study is adjusting the parameters in the Strongly Constrained and Appropriately Normed (SCAN) semilocal …

Spiral Wave Teleportation And Multiplex Network Synchronization In Light Sensitive Belousov-Zhabotinsky Systems, Shannyn Alicia Tyler

Graduate Theses, Dissertations, and Problem Reports (ETD)

We experimentally and computationally investigate dynamical behaviors in excitable and oscillatory media using light sensitive Belousov-Zhabotinsky (BZ) systems. These systems are not in a state of thermodynamic equilibrium, and have been proven to show various interesting phenomena including spatiotemporal patterns, self-organization, and chaos. We utilize the BZ reaction, a nonlinear chemical reaction, known for its relaxation-type oscillations, to explore the dynamics of these systems.

We examine spiral wave teleportation in an excitable media as an effective alternate defibrillation method. Spiral waves have emerged as a key phenomenon associated with the initiation and persistence of cardiac arrhythmias. Using a light sensitive …

Three Essays On Energy Related To State Policies And Low Carbon Transitions, Pinky Thomas

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation consists of three essays on energy-related state policies and energy transition. Each paragraph below refers to the three abstracts for the three chapters in this dissertation, respectively.

The first essay is entitled: “Impacts of State Tax and Resource Ownership Policies on Extraction: Evidence from U.S. Natural Gas Production”. The innovation of combined use of horizontal drilling and hydraulic fracturing technologies during the 2000s has allowed natural gas producers in the United States to extract natural gas and liquids from deep shale formations in a cost-efficient manner. This essay evaluates whether unconventional gas production responds to tax changes, and …

Cellular Level Changes Induced In Cancer Cells Due To Microgravity, Sai Deepika Reddy Yaram

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increase in human activity in space has revealed several kinds of physiological challenges brought on by the absence of Earth's gravitational pull. NASA observed that during spaceflight, astronauts experience a 1-1.5% monthly loss in the mineral density of weight-bearing bones, with rehabilitation efforts on Earth often proving ineffective. This issue extends to muscles, the neuro vestibular system, the cardiovascular system, and vision. Cancer has emerged as a significant cause of mortality among astronauts, with studies up to 2017 showing that 41.3% of natural cause deaths among U.S. astronauts were due to cancer, primarily due to space radiation exposure. Cancer …

Bystander Interventions For Sexual Assault Prevention Among Students In Greek Life, Caterina Defazio

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Bystander-based sexual violence (SV) prevention programs are critical on college campuses to meet federal Title IX requirements and have proven effective in reducing violence. Greek-affiliated students (members of fraternities and sororities) are at a higher risk for sexual assault than their peers, yet current training programs often do not address their specific needs. This dissertation comprises three interconnected studies that collectively aim to improve bystander intervention strategies for this high-risk group. Aim 1 - Scoping Review: A scoping review was conducted to identify and describe bystander intervention programs delivered to Greek-affiliated students in the US and Canada. An eight-database …

Venus Balloon Localization: A Map-Aided Navigation Approach Supported By A Single-Satellite, Heath Scott Cottrill

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although Venus and Earth began as twins, possessing comparable size, mass, and composition, past exploration missions have revealed that Venus is now hellishly hot, devoid of oceans, and enveloped in a carbon dioxide-filled atmosphere. To understand when and why this evolutionary divergence occurred, further exploration is required. Today, there is a growing interest in the use of aerial platforms to circumvent the harsh conditions at the surface, which limit the lifetime of landed instruments. In this concept, a single balloon, propelled by the ambient wind field, would operate in the atmosphere at an altitude between 50 and 70 km, where …

An Examination Of Coping Resources And Strategies Among Appalachian Transgender And Gender Nonconforming Adults And Youth, Zachary Ramsey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background. The body of literature shows that TGNC adults and youth face a multitude of health disparities (e.g., depression, anxiety, suicidal ideation, eating disorders, body dysmorphia) due to their marginalization. Neither Meyer’s Minority Stress Model nor Testa’s Gender Minority Stress and Resilience Model sufficiently examines coping and the ways it interacts with other concepts within the model. Aims. The objective of this dissertation was to examine the coping resources and strategies of Appalachian transgender and gender nonconforming individuals. The three aims of this study were to: 1) evaluate the relationship of coping resources and strategies between TGNC Youth and cisgender …

Data-Driven Modeling Of Oxygen Kinetics In La0.6sr0.4co0.2fe0.8o3−Δ (Lscf) For High-Temperature Reduction Of Co2 In An Electrolysis Cell, Ferron Campbell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electrolysis systems are critical to several societal applications, particularly energy storage and conversion. Developing these systems requires a detailed knowledge of the chemistry and thermodynamics of the materials used in the electrolysis cell. This work focuses on using embedded scientific machine learning as an efficient way to build an interpretable model for the reaction and transport kinetics in the LSCF electrode, whose performance directly influences the electrolysis system’s performance. The models developed in this study are trained using the publicly available machine learning package, FoKL-GP. This package incorporates a robust Gibbs sampler that employs a forward variable selection process to …

Making Something Out Of Nothing: Immobility As An Operant, KaʻAla K. Bajo

Graduate Theses, Dissertations, and Problem Reports (ETD)

The tradition of research in the experimental analysis of behavior generally emphasizes the analysis of overt, discrete responses such as lever presses or key pecks. Reflecting this emphasis, definitions of behavior involve the observable action or movement of an organism through space. Although continuous responses involving little to no movement, such as “holding still” or “immobility”, fall outside these definitions, immobility is a form of continuous, operant responding that can be learned and experimentally controlled. Three experiments were conducted to investigate parameters surrounding immobility as an operant. In Experiment 1, immobility in the form of platform-standing bouts was shaped and …

Policy Dynamics In Young Democracies: Attention, Electoral Change, And Responsiveness In Ghana And South Africa, Christiana Bugri

Graduate Theses, Dissertations, and Problem Reports (ETD)

My dissertation is a collection of three essays that assess the nature of government attention in young democracies. Theories of the policy process focus on policy dynamics in Western democracies with little application to non-Western democracies. This dissertation bridges this gap by studying policy dynamics in the neopatrimonial democracies of Ghana and South Africa. The dissertation sheds light on how the unique features of young democracies (centralization, clientelism, and powerful executives) shape government attention, responsiveness to public opinion, and the importance of elections in policy change. The first essay examines the dynamics of government attention and how the neopatrimonial nature …

An Appalachian Perspective On Suicide: A Focus On West Virginia’S Unique Context, Erin Delaney Caswell

Graduate Theses, Dissertations, and Problem Reports (ETD)

INTRODUCTION: The Appalachian region, spanning 13 states from New York to northern Mississippi, experiences the suicide rates in the United States (U.S.), underscoring a public health crisis exacerbated by persistent socioeconomic challenges. West Virginia (WV), the only state entirely within Appalachia, serves as a focal point for understanding the broader suicide crisis in the region, as WV has the highest suicide rates in the region. Moreover, the state has several unique socioeconomic factors, like increased poverty, lower educational attainment, limited access to healthcare, and a high prevalence of chronic pain and substance that may contribute to elevated rates of suicide. …

Laser Deposition Additive Manufacturing Of Multi-Material And Metal-Ceramic Composite Structures, Manikanta Grandhi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increasing performance requirements of modern industrial systems, coupled with the imperative for decarbonization, necessitate a fundamental rethinking of metallic component design and manufacturing. Traditional materials, with their inherent limitations in property optimization, susceptibility to degradation, and weight constraints, are proving insufficient. Multi-material joining offers a potential solution, enabling designers to strategically integrate diverse materials with specific, tailored properties into single component. Functionally graded materials (FGMs) and oxide dispersion strengthened (ODS) materials are prime examples of this approach, delivering substantial improvements in wear resistance, thermal regulation, high-temperature resilience, and overall weight efficiency. However, conventional manufacturing approaches further exacerbate the limitations …

Triggered Online System Re-Identification Applied To Model Predictive Control Using Gaussian Processes, Daniel Augusto Kestering

Graduate Theses, Dissertations, and Problem Reports (ETD)

Safety, product quality, enhanced performance, and increased profit all depend on the control of chemical and energy processes. However, operational issues can lead to control challenges, especially when processes are subject to disturbances during their operation. Process control methods work best when processes operate close to their designed operat- ing conditions, but lack of performance or other issues may occur when the process is far from such conditions. To overcome these challenges, in this dissertation, online model re- identification is proposed for Model Predictive Control (MPC). This involves reassessing the predictive model of an advanced controller, namely MPC, when re-identification …

Piano Wisdom From Two Great Masters: Heinrich Neuhaus And Walter Gieseking, Xiaohan Hu

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the pedagogical insights and piano techniques of Heinrich Neuhaus (1888-1964) and Walter Gieseking (1895-1956), two iconic figures in 20th-century piano performance and education. Through a detailed analysis of their writings and teaching methods, the research highlights their shared focus on the foundational principles of piano technique, as well as their unique contributions to interpretation and musical expression.

Neuhaus’s The Art of Piano Playing provides an in-depth discussion on the importance of artistic imagery, posture, sound production, and emotional depth in performance. Gieseking, along with his former teacher Karl Leimer, emphasizes ear training, mental visualization, and technical precision …

Using Touchmath® As An Intervention For Students With Disabilities At A Public Montessori School, Anne M. Cox

Graduate Theses, Dissertations, and Problem Reports (ETD)

Students with high-incidence disabilities enrolled in public Montessori elementary schools do not always make adequate growth in mathematics using traditional Montessori materials and instruction. While direct instruction methods are not typically used in a Montessori setting, such teaching practices have been proven to be successful when teaching students with disabilities.

This study analyzed the effects of an evidence-based math intervention, TouchMath^®, on the addition fact fluency and acquisition of double-digit addition skills of elementary students with disabilities who receive small-group special education instruction in a public Montessori school. The students’ confidence levels before and after receiving the intervention …

Pathways To Health: Linking Accessible Green Space To Improved Health And Well‐Being In Rural Appalachia., Udday Shankur Datta

Graduate Theses, Dissertations, and Problem Reports (ETD)

Green spaces are essential for our physical health. The quality of its green space often determines the health of a community. The presence of green space in our lives is associated with reduced stress levels, better sleep, and increased feelings of safety. Lack of access to green space can lead to many health issues, such as high blood pressure, diabetes, and cardiovascular diseases, and has been linked to obesity and physical inactivity.

The Appalachian Regional Commission (ARC) defines Appalachia as a region covering 420 counties across 13 states in the eastern United States. A large part of this region is …

Celluloid Shakespeare: An Exploration Of The Relationship Between Film And Theatre Through Edgar In Shakespeare’S King Lear, Liam Michael Holton

Graduate Theses, Dissertations, and Problem Reports (ETD)

This document explores the actor‘s process and performance of Edgar in the 2021 WVU/WVPB production of William Shakespeare‘s King Lear. This production was directed by Professor Jerry McGonigle and was filmed during the height of the Covid-19 pandemic in partnership with West Virginia Public Broadcasting. This experimental project would go on to receive national distribution by the National Educational Television Association (NETA) and was also in consideration for a NETA award, in addition to receiving an Ohio Valley regional Emmy Award nomination as a finalist in the category of Arts/Entertainment – Short Form or Long Form Content. The following text …

Novel Membrane Materials For Nutrient Recovery From Nutrient-Rich Resources, Km Prottoy Shariar Piash

Graduate Theses, Dissertations, and Problem Reports (ETD)

Global demand for fertilizer production is expanding substantially to meet the food demand of an increasing world population. Anaerobic digestate (AD) of various centralized wastewater facilities contains substantial amounts of ammonium (NH₄⁺) (300-800 mg/L), potassium (K⁺) (13-120 mg/L), and phosphorus (P) (30-100 mg/L)- based nutrients. In addition to reducing energy costs and CO₂ emissions compared to conventional fertilizing raw material manufacturing, recovering nutrients from these waste streams could help mitigate problems such as eutrophication, which otherwise incurs billions of dollars losses to US economy annually. Apart from nutrients, wastewater streams also contain organic pollutants …