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2024

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Teaching An English Geography Curriculum Abroad: Who Is The Other?, Kay Chapman Jan 2024

Teaching An English Geography Curriculum Abroad: Who Is The Other?, Kay Chapman

School of Law, Humanities and Social Sciences Theses

In former British colonies, such as Sri Lanka, affluent families from that country may choose to send their children to international schools because they want their children to have a British education and qualifications and be taught by British teachers. This research investigates how some of the actors involved negotiate a geography curriculum constructed for sixteen year olds in England with pupils from Sri Lanka. This small scale, multi-method, qualitative study focuses on one geography department at one international school in Sri Lanka. Data collected includes in-depth interviews with a Sri Lankan teacher, British teachers at the school and an …


'Man's Forgotten Friend': Dogs Appointed As Domesticated Companions And The Coronavirus Pandemic, Rebekah Gregory Jan 2024

'Man's Forgotten Friend': Dogs Appointed As Domesticated Companions And The Coronavirus Pandemic, Rebekah Gregory

School of Law, Humanities and Social Sciences Theses

The metaphorical confinement of national lockdowns saw the egocentric adoption of dogs appointed as domesticated companions. While public approval of ‘animal’ welfare legislation and the growing popularity of ‘green’ theory and industry has grown, ‘animals’ are still victim to the consumer and the anthropocentric cultures which promote individual, economic, social, and specifically ‘human’ advancement at all costs. Even though the reasons why ‘animals’ are victimised has been researched, how the pandemic has impacted upon this treatment and consumer culture’s/anthropocentrism’s influence has been somewhat absent within academic discussion. In fact, how the global events of COVID-19 have impacted upon dog treatment, …


'A Knock At The Door': A Memoir With A Supplemental Dissertation About Its Craft In The Context Of Alan Bennett's 'The Lady In The Van' And Lemn Sissay's 'My Name Is Why', Robert Parsons Jan 2024

'A Knock At The Door': A Memoir With A Supplemental Dissertation About Its Craft In The Context Of Alan Bennett's 'The Lady In The Van' And Lemn Sissay's 'My Name Is Why', Robert Parsons

School of Law, Humanities and Social Sciences Theses

My project has two elements: a memoir, titled 'A Knock at the Door', and a critical dissertation.On December 23rd, 1975, Ronnie, a homeless man who had spent the majority of his childhood in care and had educational challenges, knocked on our door. At that time, I was a young lawyer and had been married for four years. I invited him in; my wife and I gave him a meal and offered that he stay the night. He never left. He died in September 2020 having lived with us for forty-five years. During that time, we had children, brought them up …


An Exploration Of Anti-Terrorism Policy Implementation In Nigeria, Wisdom Momodu Osagiede Ogbeowemwenkon Osemwende Jan 2024

An Exploration Of Anti-Terrorism Policy Implementation In Nigeria, Wisdom Momodu Osagiede Ogbeowemwenkon Osemwende

Walden Dissertations and Doctoral Studies

AbstractAntiterrorism Policy Implementation in Nigeria By COL.Wisdom M. Osagiede Ogbeowemwenkon Osemwende (Ret) United States Army United States Army Command and General Staff College, 2009 Combined Arms and Service School, 2003 United States Army Chemical Corp School Officer Advance Course, 2000 John F. Kennedy Special Warfare Center & School – CA, 1999 John F. Kennedy Special Warfare Center & School – PSYOP, 1997 MA, Southern University and A&M College, 1991 United States Army R.O.T.C. 1991 BS, Southern University and A&M College, 1990

Dissertation Submitted in Partial Fulfillmentof the Requirements for the Degree of Doctor of Philosophy Public Policy and Administration

Walden …


A Multidisciplinary Approach To Managing Financial Toxicity In Oncology Patients, Katelin Muse Jan 2024

A Multidisciplinary Approach To Managing Financial Toxicity In Oncology Patients, Katelin Muse

Walden Dissertations and Doctoral Studies

Patients with a cancer diagnosis are counseled at length about the standard of care treatment options, which may include surgery, radiation, anticancer medications, and chemo/immunotherapy through an informed consent process. Unfortunately, the potential economic burden and the accompanying psychological burden is seldom discussed up front. There is a significant need for routine screening and a multidisciplinary approach to the prevention of financial toxicity for the oncology patient. The purpose of this doctoral project was to lead an interprofessional team in the development of a clinical practice guideline for routine financial screening using the Comprehensive Score for Financial Toxicity (COST) tool …


Microstructural Analysis Does Not Support Altered Interhemispheric Wiring Of The Human Anterior Commissure In Corpus Callosum Dysgenesis, Timothy J Edwards, Ryan J Dean, Gail A Robinson, Jacquelyn Knight, Simone A Mandelstam, Linda J Richards Jan 2024

Microstructural Analysis Does Not Support Altered Interhemispheric Wiring Of The Human Anterior Commissure In Corpus Callosum Dysgenesis, Timothy J Edwards, Ryan J Dean, Gail A Robinson, Jacquelyn Knight, Simone A Mandelstam, Linda J Richards

2020-Current year OA Pubs

BACKGROUND: Individuals with corpus callosum dysgenesis (CCD) lack the clear disconnection syndrome that is characteristic of individuals in whom the corpus callosum has been surgically severed. One potential explanation for this paradox is that the anterior commissure undergoes neuroplastic remodeling in CCD to improve interhemispheric communication between the brain hemispheres.

METHODS: A cohort of sixteen individuals with CCD (and sixteen sex and age-matched neurotypical controls) underwent multi-shell diffusion magnetic resonance high-field imaging (dMRI) at 7-Tesla to assess the anatomy of the anterior commissure for evidence of neuroplasticity.

RESULTS: No significant group-wise differences in midsagittal anterior commissure volumes were detected between …


Atomically Dispersed Zeolite-Supported Rhodium Complex: Selective And Stable Catalyst For Acetylene Semi-Hydrogenation, Yuxin Zhao, Özge D. Bozkurt, Samira F. Kurtoğlu-Öztulum, Melisa Su Yordanli, Adam S. Hoffman, Jiyun Hong, Jorge E. Perez-Aguilar, Aylin Saltuk, Deniz Akgül, Tülay Ateşin Jan 2024

Atomically Dispersed Zeolite-Supported Rhodium Complex: Selective And Stable Catalyst For Acetylene Semi-Hydrogenation, Yuxin Zhao, Özge D. Bozkurt, Samira F. Kurtoğlu-Öztulum, Melisa Su Yordanli, Adam S. Hoffman, Jiyun Hong, Jorge E. Perez-Aguilar, Aylin Saltuk, Deniz Akgül, Tülay Ateşin

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Highlights

  • Rhodium has heretofore been known to be unselective for acetylene semi-hydrogenation.

  • Electronic properties of rhodium are tuned by choice of support and metal nuclearity.

  • Selectivity is maximized when Rh is atomically dispersed on a weak electron donor.

  • Zeolite-supported Rh complex with C2H2 ligands offers a stable C2H4 selectivity > 90 %.

  • Results demonstrate unprecedented catalytic properties of Rh for semi-hydrogenation.

Abstract

Supported rhodium catalysts are known to be unselective for semi-hydrogenation reactions. Here, by tuning the electronic structure of supported mononuclear rhodium sites determined by the metal nuclearity and the electron-donor properties of the support, we report that atomically dispersed …


Systematic Computer-Aided Disulfide Design As A General Strategy To Stabilize Prefusion Class I Fusion Proteins, Karen J Gonzalez, Kevin C Yim, Jorge C G Blanco, Marina S Boukhvalova, Eva-Maria Strauch Jan 2024

Systematic Computer-Aided Disulfide Design As A General Strategy To Stabilize Prefusion Class I Fusion Proteins, Karen J Gonzalez, Kevin C Yim, Jorge C G Blanco, Marina S Boukhvalova, Eva-Maria Strauch

2020-Current year OA Pubs

Numerous enveloped viruses, such as coronaviruses, influenza, and respiratory syncytial virus (RSV), utilize class I fusion proteins for cell entry. During this process, the proteins transition from a prefusion to a postfusion state, undergoing substantial and irreversible conformational changes. The prefusion conformation has repeatedly shown significant potential in vaccine development. However, the instability of this state poses challenges for its practical application in vaccines. While non-native disulfides have been effective in maintaining the prefusion structure, identifying stabilizing disulfide bonds remains an intricate task. Here, we present a general computational approach to systematically identify prefusion-stabilizing disulfides. Our method assesses the geometric …


Unmet Patient Needs In Monocarboxylate Transporter 8 (Mct8) Deficiency: A Review, Andrew J Bauer, Bethany Auble, Amy L Clark, Tina Y Hu, Amber Isaza, Kyle P Mcnerney, Daniel L Metzger, Lindsey Nicol, Samuel R Pierce, Richard Sidlow Jan 2024

Unmet Patient Needs In Monocarboxylate Transporter 8 (Mct8) Deficiency: A Review, Andrew J Bauer, Bethany Auble, Amy L Clark, Tina Y Hu, Amber Isaza, Kyle P Mcnerney, Daniel L Metzger, Lindsey Nicol, Samuel R Pierce, Richard Sidlow

2020-Current year OA Pubs

Monocarboxylate transporter 8 (MCT8) deficiency is a rare, X-linked disorder arising from mutations in the


Reimagining Youngblood's Bad Faith Requirement: Safeguarding Criminal Defendants' Due Process Rights Through A Burden-Shifting Framework, Rita Elfarissi Jan 2024

Reimagining Youngblood's Bad Faith Requirement: Safeguarding Criminal Defendants' Due Process Rights Through A Burden-Shifting Framework, Rita Elfarissi

Michigan Law Review

Criminal defendants face an uphill battle when attempting to prove that the government’s loss or destruction of evidence that could have played a significant role in their defense deprived them of their constitutional due process rights. To make this showing, the defendant must prove that the government lost or destroyed the evidence in bad faith. This requirement is problematic because direct evidence illustrating the subjective intent of the government officials who lost or destroyed the evidence is unlikely to exist, and in the off chance it does, the prosecution is unlikely to freely hand it over to the defendant. Thus, …


Public Accommodations Parlance, Grace Vedock Jan 2024

Public Accommodations Parlance, Grace Vedock

Michigan Law Review

Anxieties linger in the interstices of public accommodations law. 303 Creative LLC v. Elenis is the latest in a string of First Amendment cases that call into question the common law duties underpinning public accommodations doctrine. Many commentators have speculated about the decision’s immediate implications. But criticism of the decision is incomplete. This Note takes 303 Creative as a welcome opportunity to reevaluate basic assumptions about how property law operates in relation to constitutional norms. Beginning with the provocative assertion that no legal axiom is infallible, this Note examines permutations of public accommodations and First Amendment law as rhetorical threads …


Front Matter Jan 2024

Front Matter

Michigan Law Review

Front Matter for Volume 123, Issue 2 of Michigan Law Review


Penalizing Precarity, Goldburn P. Maynard Jr., Clinton G. Wallace Jan 2024

Penalizing Precarity, Goldburn P. Maynard Jr., Clinton G. Wallace

Michigan Law Review

Retirement policy in America is oriented around 401(k) plans and other employer- sponsored savings plans, which together will receive a whopping $1.5 trillion in tax subsidies over the next decade. This Article uncovers a harmful flaw in the policy governing withdrawals made prior to reaching retirement age: an unnoticed gap between the rules governing plan distributions and the rules imposing penalties on employees in certain situations. Employees are generally required to seek approval from their plan administrator to receive a “hardship distribution.” These requests are granted for employees who face an “immediate and heavy financial need,” such as eviction or …


Improving Parental Communication With Adolescents About Sex, Amanda Blanton Jan 2024

Improving Parental Communication With Adolescents About Sex, Amanda Blanton

Doctor of Nursing Practice Projects

In 2018, 68 million people in the United States were infected with a sexually transmitted infection. Of those 68 million, 26 million cases were newly diagnosed, and of that 26 million, half were youth aged 15-24 (Centers for Disease Control and Prevention [CDC], 2022a). The approaches to educating our youth about sexual health are inconsistent, leading to misconceptions about the dangers associated with risky sexual behavior. However, parents have the upper hand in discussing sexual health information with their children by being the child’s first contact and source of information. Teens who report talking with their parents about sex are …


Determining The Need For 23-Hour Observation Following Transforaminal Lumbar Interbody Fusions: A Patient Perspective On Recovery At Home, Lacey Irias Jan 2024

Determining The Need For 23-Hour Observation Following Transforaminal Lumbar Interbody Fusions: A Patient Perspective On Recovery At Home, Lacey Irias

Doctor of Nursing Practice Projects

Minimally invasive surgery (MIS) for transforaminal lumbar interbody fusion (TLIF) is becoming more frequently performed in ambulatory surgery centers (ASCs). Subsequently, patients are scheduled for an option to undergo a 23-hour observation which requires staff preparation. The preparation increases costs and creates a shortage during a standard daytime shift which can reflect negatively on patient care. Most patients elect to be discharged the same day, on account of experiencing minimal pain and seeking the comfort of their own home. The goal of this DNP project was to assess the necessity of scheduling a patient 23 hours for observation following a …


Increasing Organ Donation In A University Setting, Zachary Hatton Jan 2024

Increasing Organ Donation In A University Setting, Zachary Hatton

Doctor of Nursing Practice Projects

The literature shows a strong correlation between education on organ donation and increased organ donation registration. Society has depicted a description of organ donation that is hostile and untrue. Increasing organ donation registration with knowledge sets the foundation of a grassroots movement to increase understanding and change society’s viewpoint(s) on organ donation. An education session on organ donation was developed and presented to the targeted population of 18–24-year-old students at a university in the foothills of the Appalachian Mountains. The focal point of the presentation was to dispel myths, educate on facts, and create a better understanding of organ donation …


Introducing Mental Health Resources To Nurse Practitioner Residents, Tiffanie Bailey Jan 2024

Introducing Mental Health Resources To Nurse Practitioner Residents, Tiffanie Bailey

Doctor of Nursing Practice Projects

This DNP Project identified the increased need for mental health resources after the COVID-19 pandemic. Studies showed the rate of anxiety, depression, and substance use has also been on the rise since the beginning of the pandemic. As the impact of the COVID-19 pandemic began to devastate the country mentally and physically, it became quickly apparent that additional resources to provide support for those suffering from mental illness were essential. This project aimed to introduce a Mental Health First Aid course within the Residency Program at the Center for Family Guidance. Participants were asked to complete a pre-test indicating their …


Bridging The Gap: Strategies To Enrich The Clinical Experience Of Undergraduate Nursing Students To Improve Clinical Judgment Skills, Gabrielle Hope Jan 2024

Bridging The Gap: Strategies To Enrich The Clinical Experience Of Undergraduate Nursing Students To Improve Clinical Judgment Skills, Gabrielle Hope

Doctor of Nursing Practice Projects

Introduction: The lack of competent clinical judgement among new graduate nurses contributes to poor patient outcomes, negatively impacting patient satisfaction scores, and subsequently raising the cost of healthcare for consumers. This project explores how reflective journaling and cooperative learning activities contribute to the development of critical thinking of nursing students during their Nursing Fundamentals clinical practicum.

Methods: Seventeen students enrolled in a private university nursing program were selected as the sample. The students were introduced to the recommended learning strategies and invited to anonymously participate in a pre-survey and post-survey. The surveys were identical in content and consisted …


Er Staff & Burnout: Interventions For Stress Management, Sara Elizabeth Kerbow Jan 2024

Er Staff & Burnout: Interventions For Stress Management, Sara Elizabeth Kerbow

Doctor of Nursing Practice Projects

Nursing is one of the most difficult professions, not only physically exhausting but the mental and emotional toll can create havoc for the person’s life (Scala & Drummond, 2016). This DNP project, “Reset”, was founded on the concept of nursing burnout, compassion fatigue, and secondary trauma causing overwhelming stress related to the emergency room nurse and staff. The purpose of this project was to show how a 15-minute mental health reset can play an essential role in stress reduction. By using complementary health modalities such as lavender essential oil with diffuser, visual imagery, and massage while listening to soft calming …


Cardiovascular Disease Improvement Project, Deglan K. Mccrystal Jan 2024

Cardiovascular Disease Improvement Project, Deglan K. Mccrystal

Doctor of Nursing Practice Projects

Health prevention promotes positive healthcare outcomes by identifying risk factors associated with a disease process in its early stages to halt or slow its progression. Preventions, like routine screenings, facilitate the identification of risk factors or the initiation of treatment of a disease. Identifying risk factors, which often go unrecognized, helps to manage conditions like cardiovascular disease before it progresses in severity. Early treatment options or identifying risk factors that lead to cardiac disease positively impact healthcare costs by reducing the number of hospital visits, emergency services, and the need for costly long-term care. Prevention increases the quality of disease …


Improving Sexually Transmitted Infections (Sti) Education And Access To Education For Healthcare Workers In A Rural Ambulatory Clinic, Savannah Elmore Jan 2024

Improving Sexually Transmitted Infections (Sti) Education And Access To Education For Healthcare Workers In A Rural Ambulatory Clinic, Savannah Elmore

Doctor of Nursing Practice Projects

Sexually transmitted infections (STIs) are prevalent across the United States, with one in five people diagnosed in 2018, resulting in nearly $16 billion in medical costs. The prevention and treatment of STIs have been identified as a priority area for improvement, with healthcare providers playing a critical role in education, diagnosing, and treating STIs. The aim of this capstone project was to improve STI education and access to education for healthcare workers in a rural ambulatory clinic. Through a needs assessment and the development of objectives and a timeline, the project identified and addressed gaps in STI education and resources, …


Identifying Patients Suffering From Housing Instability In The Emergency Department, Jarvis D. Roberts Jan 2024

Identifying Patients Suffering From Housing Instability In The Emergency Department, Jarvis D. Roberts

Doctor of Nursing Practice Projects

Homelessness is the most visible form of housing instability in the United States of America. Yet, millions of people across our nation live in unstable housing, which consists of temporary housing, shelters, outside encampments, and vehicles. Many citizens facing these types of insecurities live paycheck to paycheck and are one health crisis or emergency away from financial ruin. The COVID-19 pandemic, inflation, and slow hourly wage growth have exacerbated this situation. This project aimed to construct a screening tool to identify patients suffering from housing instability in the emergency department setting and provide them with community resources.


Substance Abuse Awareness Amongst Practicing Nurses, Marjenia Williams Jan 2024

Substance Abuse Awareness Amongst Practicing Nurses, Marjenia Williams

Doctor of Nursing Practice Projects

Background: This paper discusses the problem and potential solutions of substance abuse amongst practicing nurses. Substance abuse is prevalent among 10% of the nursing population in the United States (Sofer, 2019). This problem is more significant than the public realizes. It is essential that new nurses and student nurses become aware of the risks and the causes of substance abuse within the culture prior to them practicing.

Methods: A 45-minute educational presentation based upon 10 peer-reviewed articles which include five articles regarding the problem and five discussing solutions was utilized to facilitate open discussion of the topic. The …


Fostering Relationships Between New Graduate Nurses And Leadership To Increase Retention, Michelle Cotton Jan 2024

Fostering Relationships Between New Graduate Nurses And Leadership To Increase Retention, Michelle Cotton

Doctor of Nursing Practice Projects

Objective: To implement weekly one-on-one touch bases between nursing leaders, such as managers and directors, with newly hired, new graduate nurses, up to 1 year after graduation to improve retention of those employees. The intent is to improve retention from a baseline of 23% in 2022.

Results: 35.8% of the newly hired nurses plan to remain in their current role for the next 2-3 years.

Conclusions: Almost 55% said that they strongly agreed with the touch base contributing to development/growth. This was the lowest scoring question and the most concerning related to retention. An overwhelming majority felt …


A Review Of The Effects Of Different Types Of Stigmas On The Retention Rates Of Patients In Medication-Assisted Treatment And How To Combat The Problem, Pamela Cox Jan 2024

A Review Of The Effects Of Different Types Of Stigmas On The Retention Rates Of Patients In Medication-Assisted Treatment And How To Combat The Problem, Pamela Cox

Doctor of Nursing Practice Projects

It is difficult to turn on the news without hearing about the opioid epidemic or a recent opioid overdose. There is hope because there is a treatment to help prevent this epidemic. That treatment is known as medication-assisted therapy (MAT), where patients can present and, if they meet the criteria, can be given a prescription for buprenorphine/naloxone combination medication. Treatment with buprenorphine/naloxone has been shown to be highly effective treatment for substance use disorder (SUD). Even though it has been proven that this combination works, less than 20% of patients diagnosed with SUD present for treatment. This study focused on …


Combating The Opioid Crisis: Opioid And Naloxone Training In A Rural School District, Phadra K. Murray Jan 2024

Combating The Opioid Crisis: Opioid And Naloxone Training In A Rural School District, Phadra K. Murray

Doctor of Nursing Practice Projects

Background: The opioid epidemic is plaguing North Carolina and has crept its way into the academic setting of many elementary, middle, and high schools in the state, causing school nurses to scramble and search for ways to keep students safe. This DNP project was designed to educate school nurses in a rural county in eastern North Carolina about opioid education and naloxone administration. This project intended to increase the knowledge and confidence level of school nurses in case of an opioid overdose emergency within the school. As more and more children and adolescents experiment with opioids, there is an urgent …


Incorporating Simulation Experiences Into The Nurse Aide Curriculum To Improve Clinical Judgment, Tonya A. May Jan 2024

Incorporating Simulation Experiences Into The Nurse Aide Curriculum To Improve Clinical Judgment, Tonya A. May

Doctor of Nursing Practice Projects

This DNP Project was designed to strengthen clinical judgment skills in nurse aide students. Incorporating simulation-based learning opportunities into the nurse aide curriculum supports the development of clinical judgment skills. Four simulation scenarios were designed to focus on the student's ability to respond within the nurse aide’s scope of practice. Pre-test and post-test surveys were developed with a 5-point Likert scale (1 = strongly agree, 2 = agree, 3 = neither agree nor disagree, 4 = disagree, 5 – strongly disagree) to assess the student's perception of their ability to perform, notice, interpret, respond, and reflect on patient care. A …


A Multisociety Delphi Consensus Statement On New Fatty Liver Disease Nomenclature, Mary E Rinella, Samuel Klein, Et Al. Jan 2024

A Multisociety Delphi Consensus Statement On New Fatty Liver Disease Nomenclature, Mary E Rinella, Samuel Klein, Et Al.

2020-Current year OA Pubs

The principal limitations of the terms NAFLD and NASH are the reliance on exclusionary confounder terms and the use of potentially stigmatising language. This study set out to determine if content experts and patient advocates were in favor of a change in nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. The consensus was defined a priori as a supermajority (67%) vote. An independent committee of experts external to the nomenclature process made the final recommendation on the acronym and its diagnostic criteria. A total of 236 panelists from 56 countries participated in 4 …


Educating Future Generations Of Surgeons Across Borders: Novel Global Linked Hybrid Live Cadaveric Peripheral Nerve Surgical Training Course, Abdus S Burahee, Liron S. Duraku, Caroline A. Hundepool, Kyle R Eberlin, Amy Moore, Christopher J. Dy, Shalimar Abdullah, Vaikunthan Rajaratnam, J. Michiel Zuidam, Dominic M. Power Jan 2024

Educating Future Generations Of Surgeons Across Borders: Novel Global Linked Hybrid Live Cadaveric Peripheral Nerve Surgical Training Course, Abdus S Burahee, Liron S. Duraku, Caroline A. Hundepool, Kyle R Eberlin, Amy Moore, Christopher J. Dy, Shalimar Abdullah, Vaikunthan Rajaratnam, J. Michiel Zuidam, Dominic M. Power

2020-Current year OA Pubs

BACKGROUND: This study aimed to evaluate a novel, multi-site, technology-facilitated education and training course in peripheral nerve surgery. The program was developed to address the training gaps in this specialized field by integrating a structured curriculum, high-fidelity cadaveric dissection, and surgical simulation with real-time expert guidance.

METHODS: A collaboration between the Global Nerve Foundation and Esser Masterclass facilitated the program, which was conducted across three international sites. The curriculum was developed by a panel of experienced peripheral nerve surgeons and included both text-based and multimedia resources. Participants' knowledge and skills were assessed using pre- and postcourse questionnaires.

RESULTS: A total …


Bradykinin Receptor Expression And Bradykinin-Mediated Sensitization Of Human Sensory Neurons, Jiwon Yi, Zachariah Bertels, John Smith Del Rosario, Allie J. Widman, Richard A. Slivicki, Maria Payne, Henry M. Susser, Bryan A. Copits, Robert W. Gereau 4th Jan 2024

Bradykinin Receptor Expression And Bradykinin-Mediated Sensitization Of Human Sensory Neurons, Jiwon Yi, Zachariah Bertels, John Smith Del Rosario, Allie J. Widman, Richard A. Slivicki, Maria Payne, Henry M. Susser, Bryan A. Copits, Robert W. Gereau 4th

2020-Current year OA Pubs

Bradykinin is a peptide implicated in inflammatory pain in both humans and rodents. In rodent sensory neurons, activation of B1 and B2 bradykinin receptors induces neuronal hyperexcitability. Recent evidence suggests that human and rodent dorsal root ganglia (DRG), which contain the cell bodies of sensory neurons, differ in the expression and function of key GPCRs and ion channels; whether bradykinin receptor expression and function are conserved across species has not been studied in depth. In this study, we used human DRG tissue from organ donors to provide a detailed characterization of bradykinin receptor expression and bradykinin-induced changes in the excitability …