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2024

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Potential Use Of Poultry Farms By Wild Waterfowl In California's Central Valley Varies Across Space, Times Of Day, And Species: Implications For Influenza Transmission Risk, Claire S. Teitelbaum, Michael L. Casazza, Cory T. Overton, Jeffery D. Sullivan, Elliott L. Matchett, Fiona Mcduie, Austen A. Lorenz, Joshua T. Ackerman, Susan E.W. De La Cruz, Diann J. Prosser Jan 2024

Potential Use Of Poultry Farms By Wild Waterfowl In California's Central Valley Varies Across Space, Times Of Day, And Species: Implications For Influenza Transmission Risk, Claire S. Teitelbaum, Michael L. Casazza, Cory T. Overton, Jeffery D. Sullivan, Elliott L. Matchett, Fiona Mcduie, Austen A. Lorenz, Joshua T. Ackerman, Susan E.W. De La Cruz, Diann J. Prosser

Faculty Research, Scholarly, and Creative Activity

Interactions between wildlife and livestock can lead to cross-species disease transmission, which incurs economic costs and threatens wildlife conservation. Wild waterfowl are natural hosts of avian influenza viruses (AIVs), are often abundant near poultry farms, and have been linked to outbreaks of AIVs in poultry. Interspecific and seasonal variation in waterfowl movement and habitat use means that the risk of disease transmission between wild birds and poultry inevitably varies across species, space, and time. Here, we used GPS telemetry data from 10 waterfowl species in and near California's Central Valley, a region where both wild waterfowl and domestic poultry are …


Emf Revisited, Art Davis Jan 2024

Emf Revisited, Art Davis

Faculty Research, Scholarly, and Creative Activity

This paper was inspired by a recent publication by Redžíc (2018 Eur. J. Phys. 39 025205) which threw into bold relief the differences between the way Maxwell viewed the current and the way Lorentz visualized it. We make the assumption that for a circuit of laboratory dimensions current (and charge perturbation effects in general) can be assumed to propagate instantaneously around the loop. Our second fundamental assumption is the commonly accepted one that E is the force per unit charge on a stationary charge. We use these facts to make the usual definition of electromotive force more rigorous and to …


Interpreting For Boris Pilnyak In New York City During 1931, Albert Parry Jan 2024

Interpreting For Boris Pilnyak In New York City During 1931, Albert Parry

Faculty Publications

The following text is an excerpt from Albert Parry’s hitherto unpublished memoirs, Ask That Your Way Be Long: An Autobiography. As becomes evident from reading his obituary in the New York Times (May 8, 1992), Professor Parry led a very colorful and highly interesting life. Having escaped from his hometown of Rostov-on-Don in the midst of the Russian Civil War, and then emigrating to the United States in 1921, he proceeded to develop a successful career for himself as a writer and journalist in New York City during the 1920s and early 1930s, before moving to the Midwest to …


Participation In Collaborative Fisheries Research Improves The Perceptions Of Recreational Anglers Towards Marine Protected Areas, Erin M. Johnston, Grant T. Waltz, Rosamaria Kosaka, Ellie M. Brauer, Shelby L. Ziegler, Erica T. Jarvis Mason, Hunter S. Glanz, Lauren Zaragoza, Allison N. Kellum, Rachel O. Brooks, Brice X. Semmens, Christopher J. Honeyman, Jennifer E. Caselle, Lyall F. Bellquist, Sadie L. Small, Steven G. Morgan, Timothy J. Mulligan, Connor L. Coscino, Jay M. Staton Jan 2024

Participation In Collaborative Fisheries Research Improves The Perceptions Of Recreational Anglers Towards Marine Protected Areas, Erin M. Johnston, Grant T. Waltz, Rosamaria Kosaka, Ellie M. Brauer, Shelby L. Ziegler, Erica T. Jarvis Mason, Hunter S. Glanz, Lauren Zaragoza, Allison N. Kellum, Rachel O. Brooks, Brice X. Semmens, Christopher J. Honeyman, Jennifer E. Caselle, Lyall F. Bellquist, Sadie L. Small, Steven G. Morgan, Timothy J. Mulligan, Connor L. Coscino, Jay M. Staton

Faculty Research, Scholarly, and Creative Activity

Collaborative fisheries research programs engage stakeholders in data collection efforts, often with the benefit of increasing transparency about the status and management of natural resources. These programs are particularly important in marine systems, where management of recreational and commercial fisheries have historically been contentious. One such program is the California Collaborative Fisheries Research Program (CCFRP), which was designed in 2006 to engage recreational anglers in the scientific process and evaluate the efficacy of California’s network of marine protected areas. CCFRP began on the Central Coast of California and expanded statewide in 2017 to include six partner institutions in three regions: …


Keck/Kcwi Spectroscopy Of Globular Clusters In Local Volume Dwarf Galaxies, Duncan A. Forbes, Daniel Lyon, Jonah Gannon, Aaron J. Romanowsky, Jean P. Brodie Jan 2024

Keck/Kcwi Spectroscopy Of Globular Clusters In Local Volume Dwarf Galaxies, Duncan A. Forbes, Daniel Lyon, Jonah Gannon, Aaron J. Romanowsky, Jean P. Brodie

Faculty Research, Scholarly, and Creative Activity

A number of nearby dwarf galaxies have globular cluster (GC) candidates that require spectroscopic confirmation. Here we present Keck telescope spectra for 15 known GCs and GC candidates that may be associated with a host dwarf galaxy, and an additional 3 GCs in the halo of M31 that are candidates for accretion from a now disrupted dwarf galaxy. We confirm 6 star clusters (of intermediate-to-old age) to be associated with NGC 247. The vast bulk of its GC system remains to be studied spectroscopically. We also confirm the GC candidates in F8D1 and DDO190, finding both to be young star …


Health Sciences Students’ Career Commitment, Mental Health, And Physical Activity During The Covid-19 Pandemic, David Wrucke, Marie K. Hoeger Bement, April L. Harkins, Sandra K. Hunter, Stacy Stolzman, Astrida S. Kaugars Jan 2024

Health Sciences Students’ Career Commitment, Mental Health, And Physical Activity During The Covid-19 Pandemic, David Wrucke, Marie K. Hoeger Bement, April L. Harkins, Sandra K. Hunter, Stacy Stolzman, Astrida S. Kaugars

Physical Therapy Faculty Research and Publications

Objective: To understand the biopsychosocial dimensions of university health sciences students’ experiences during the COVID-19 pandemic.

Participants: Health sciences students (n = 297) from two universities in July and August 2020.

Methods: Participants completed a Web-based survey asking about depression, anxiety, physical activity, coronavirus threat, and career commitment.

Results: Moderate or severe depression and anxiety were reported by 28.6% and 31.3% of respondents, respectively. Depression and anxiety were positively correlated with perceived coronavirus threat and negatively correlated with career commitment and strenuous physical activity. A change in career commitment interests during the COVID-19 pandemic was reported by 11% of …


A Multi-Omics Multi-Environment Prediction In Pulse Crop, Rica Saludares Jan 2024

A Multi-Omics Multi-Environment Prediction In Pulse Crop, Rica Saludares

Plant Sciences

Understanding the genetic bases underlying seed yield and protein, and eventually recombining them in desired genetic backgrounds, continues to be a challenge to pulse crop breeders. Phenotypic selection for seed yield and protein in preliminary yield trials is hindered by the need to phenotype a large number of early-generation lines (>10,000) with limited seeds, resulting to trials with few replications and limited environments. In this study, we evaluated and applied a multi-trait multi-environment (MTME) and a multi-omics prediction framework to address phenotyping bottleneck and the complexities underlying negatively correlated traits, and maximize connectivity among genotypes for predicting performance of …


I Hope The Final Judgment’S Fair: Alternative Jurisprudences, Legal Decision-Making, And Justice, Michael L. Perlin Jan 2024

I Hope The Final Judgment’S Fair: Alternative Jurisprudences, Legal Decision-Making, And Justice, Michael L. Perlin

Articles & Chapters

At the core of any legal decision is an assumption that the decision will be “fair,” yet this is an elusive term. A close study of cases involving criminal defendants with mental disabilities shows that many (perhaps most) of the decisions involving this cohort are not “fair” in the contexts of due process and justice. If legal decisions reflect principles such as procedural justice, restorative justice, and therapeutic jurisprudence, the chances of such fairness will be significantly enhanced. This chapter explains why this goal of fairness, in the context of these cases, can never be met absent a consideration of …


Transitional Justice And Human Rights, Ruti G. Teitel, Valeria Vegh Weis Jan 2024

Transitional Justice And Human Rights, Ruti G. Teitel, Valeria Vegh Weis

Articles & Chapters

No abstract provided.


The Intersection Of Special Education And Family Law: Thoughts For Family Law Attorneys In Divorce And Custody Cases, Richard D. Marsico Jan 2024

The Intersection Of Special Education And Family Law: Thoughts For Family Law Attorneys In Divorce And Custody Cases, Richard D. Marsico

Articles & Chapters

The Individuals with Disabilities Education Act (IDEA) requires participating states to provide a free appropriate public education (FAPE) to children with disabilities. The IDEA gives parents of children with disabilities significant rights and major responsibilities in developing and maintaining their child’s education. Getting the most out of the IDEA for their children requires parents to commit substantial time and financial resources that are difficult to provide in the best circumstances. When parents are having marital difficulties, separated, undergoing a divorce, or negotiating child custody, these difficulties can be exacerbated as parents navigate the intersection of the federal IDEA and state …


Family Law And Children’S Educational Rights: Introduction & Acknowledgements, Lisa Grumet Jan 2024

Family Law And Children’S Educational Rights: Introduction & Acknowledgements, Lisa Grumet

Articles & Chapters

No abstract provided.


Repealing Single-Family Zoning Is Not Enough: A Proposal For Removing Existing Parallel Private Covenants For Violating Public Policy, Gerald Korngold Jan 2024

Repealing Single-Family Zoning Is Not Enough: A Proposal For Removing Existing Parallel Private Covenants For Violating Public Policy, Gerald Korngold

Articles & Chapters

The United States is currently suffering a pervasive and unsettling shortage of housing and increased housing unaffordability. Rents are at an all-time high, which has a disproportionate impact on people of color and people earning lower incomes as they are more likely to rent rather than owns their homes. Moreover, people solidly in the middle class are finding it increasingly difficult to purchase residences within their budgets.

Critics have identified “single-family zoning”—allowing only one single-family home per lot--as a major cause of housing supply and affordability problems. In response, a handful of states and cities have recently passed legislation that …


Stop The Violence: A Taxonomy Of Measures To Abolish Evictions, Andrew Scherer Jan 2024

Stop The Violence: A Taxonomy Of Measures To Abolish Evictions, Andrew Scherer

Articles & Chapters

Evictions are among the harshest, most violent, disruptive, and damaging acts authorized by our civil courts. An armed official with a gun orders a tenant and their family out of their home and removes their possessions, often simply placing a family’s belongings — photos, knick-knacks, furniture, the accumulations of a life — on the sidewalk to be lost or damaged. Evictions ravage lives — they damage physical and mental health, disrupt education, cause job loss and homelessness, and dislodge people from community and stability. The violence of eviction is always implicit and often explicit. Sometimes, evictions result in armed conflict …


Ask The Professor: Will The Recent Second Circuit Decision In Sec V. Govil Adversely Impact Future Sec Disgorgement Cases—Or Not?, Ronald Filler Jan 2024

Ask The Professor: Will The Recent Second Circuit Decision In Sec V. Govil Adversely Impact Future Sec Disgorgement Cases—Or Not?, Ronald Filler

Articles & Chapters

No abstract provided.


Their Futures, So Full Of Dread: How Barefoot's Contamination Of The Death Penalty Trial Process Continues, Michael L. Perlin, Talia Roitberg Harmon, Maren Geiger, Moana Houde-Camirand Jan 2024

Their Futures, So Full Of Dread: How Barefoot's Contamination Of The Death Penalty Trial Process Continues, Michael L. Perlin, Talia Roitberg Harmon, Maren Geiger, Moana Houde-Camirand

Articles & Chapters

Forty years ago, in its most roundly-criticized criminal procedure decision in modern history, the Supreme Court, in Barefoot v. Estelle (463 U.S. 880 (1983)), a decision premised on testimony by the responses to a hypothetical of a witness who had never directly evaluated the defendant, ruled that such testimony as to future dangerousness – testimony that had concluded there was a “100% chance” the defendant would commit more crimes if released into society -- was permissible. Over a stinging dissent by Justice Blackmun, the Supreme Court had ruled in Barefoot that it was not constitutional error for psychiatrists to testify …


Foreword | The Parkland School Shooter: Culpability And Fasd, Michael L. Perlin Jan 2024

Foreword | The Parkland School Shooter: Culpability And Fasd, Michael L. Perlin

Articles & Chapters

No abstract provided.


Public Confidence, Judges, And Politics On And Off The Bench, Bruce Green, Rebecca Roiphe Jan 2024

Public Confidence, Judges, And Politics On And Off The Bench, Bruce Green, Rebecca Roiphe

Articles & Chapters

Public confidence in the judiciary is at a low point. There are multiple reasons for the public’s waning faith in judges, but the perception that they are merely politicians in robes plays a significant part. This article analyzes the politicization of the judiciary and argues that while ideology invariably affects judicial decisionmaking, the professional identity of judges limits its impact. A commitment to judicial norms and processes as well as a concern for professional reputation serve as a real break on partisan loyalty and affiliation. The task is to preserve and promote this professional identity and convey to the public …


Queer Trademarks, Michael Goodyear Jan 2024

Queer Trademarks, Michael Goodyear

Articles & Chapters

LGBTQ+ slurs can now be registered as trademarks. The U.S. Supreme Court’s decisions in Matal v. Tam and Iancu v. Brunetti allowed federal registration of disparaging, immoral, or scandalous trademarks. Appellee Simon Tam cheered, hoping that these decisions would usher in a new era of minority communities reappropriating harmful and offensive terms steeped in hate and prejudice. Others were less optimistic. Advocacy organizations, scholars, and others worried that these decisions opened the floodgates to the United States Patent and Trademark Office registering the vilest and most prejudicial terms in the U.S. lexicon to ossify hatred. Only time would tell who …


Cars, Bars, And The Delivery Of Legal Services, Rebecca Roiphe Jan 2024

Cars, Bars, And The Delivery Of Legal Services, Rebecca Roiphe

Articles & Chapters

No abstract provided.


On International Law And Gaza: Critical Reflections | Humanity Law Redux And Its Rule Of Law, Ruti G. Teitel Jan 2024

On International Law And Gaza: Critical Reflections | Humanity Law Redux And Its Rule Of Law, Ruti G. Teitel

Articles & Chapters

No abstract provided.


Cheating And The Effect Of Promises In Indian And German Children, Patricia Kanngiesser, Jahnavi Sunderarajan, Jan K. Woike Jan 2024

Cheating And The Effect Of Promises In Indian And German Children, Patricia Kanngiesser, Jahnavi Sunderarajan, Jan K. Woike

School of Psychology

Cheating is harmful to others and society at large. Promises have been shown to increase honesty in children, but their effectiveness has not been compared between different cultural contexts. In a study (2019) with 7- to 12-year-olds (N = 406, 48% female, middle-class), voluntary promises reduced cheating in Indian, but not in German children. Children in both contexts cheated, but cheating rates were lower in Germany than in India. In both contexts, cheating decreased with age in the (no-promise) control condition and was unaffected by age in the promise condition. These findings suggest that there may exist a threshold beyond …


Integrating Christian Beliefs And Scientific Psychology: Honoring John Carter, Rodger K. Bufford Jan 2024

Integrating Christian Beliefs And Scientific Psychology: Honoring John Carter, Rodger K. Bufford

Faculty Publications - Doctor of Psychology (PsyD) Program

John Carter had a profound role in shaping the thinking of generations of students and scholars in our understanding of the relationship of Christian beliefs and modern psychol- ogy. That Carter and Narramore’s (1979) volume remains in print and in use after more than four decades is a testimony to that influence. Here, I briefly explore the ways of knowing in general and elaborate on scientific knowing as a unique and powerful approach to appre- hending what our senses and instruments reveal. Scientific knowing is premised on several essential assumptions, employs a time-tested array of strategies to systematically gath- er …


Suicidality Among Black Women: Considering Resiliency Within The Historic And Societal Context Of Risk, Samantha J. North Jan 2024

Suicidality Among Black Women: Considering Resiliency Within The Historic And Societal Context Of Risk, Samantha J. North

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Suicide is a global health challenge that has been historically understudied among Black women. The interpersonal-psychological theory of suicidality (IPTS) is a primary theory examined in suicidality; however, the three factors within the theory (lack of belongingness, perceived burdensomeness, and capability to die) focus on the individual. The purpose of the current study was to examine these factors in an expanded context of the historical and societal impact of oppression. A mixed methods Qualtrics study was administered to Black women who voluntarily completed the survey anonymously. Quantitatively, the study found significant differences between the impact of the IPTS factors on …


Shedding Light On Software Engineering-Specific Metaphors And Idioms, Mia Mohammad Imran, Preetha Chatterjee, Kostadin Damevski Jan 2024

Shedding Light On Software Engineering-Specific Metaphors And Idioms, Mia Mohammad Imran, Preetha Chatterjee, Kostadin Damevski

Computer Science Faculty Research & Creative Works

Use of figurative language, such as metaphors and idioms, is common in our daily-life communications, and it can also be found in Software Engineering (SE) channels, such as comments on GitHub. Automatically interpreting figurative language is a challenging task, even with modern Large Language Models (LLMs), as it often involves subtle nuances. This is particularly true in the SE domain, where figurative language is frequently used to convey technical concepts, often bearing developer affect (e.g., 'spaghetti code). Surprisingly, there is a lack of studies on how figurative language in SE communications impacts the performance of automatic tools that focus on …


Achieving Efficient And Privacy-Preserving Reverse Skyline Query Over Single Cloud, Yubo Peng, Xiong Li, Ke Gu, Jinjun Chen, Sajal K. Das, Xiaosong Zhang Jan 2024

Achieving Efficient And Privacy-Preserving Reverse Skyline Query Over Single Cloud, Yubo Peng, Xiong Li, Ke Gu, Jinjun Chen, Sajal K. Das, Xiaosong Zhang

Computer Science Faculty Research & Creative Works

Reverse skyline query (RSQ) has been widely used in practice since it can pick out the data of interest to the query vector. To save storage resources and facilitate service provision, data owners usually outsource data to the cloud for RSQ services, which poses huge challenges to data security and privacy protection. Existing privacy-preserving RSQ schemes are either based on a two-cloud model or cannot fully protect privacy. To this end, we propose an efficient privacy-preserving reverse skyline query scheme over a single cloud (ePRSQ). Specifically, we first design a privacy-preserving inner product's sign determination scheme (PIPSD), which can determine …


Experiencing Burnout: John Henryism, Gender Role Conflict, And Anxiety Among Incarcerated Black Men, Jardin Dogan, Danelle Stevens-Watkins, Brittany Miller-Roenigk, Christopher K. Marshburn, Myles Moody Jan 2024

Experiencing Burnout: John Henryism, Gender Role Conflict, And Anxiety Among Incarcerated Black Men, Jardin Dogan, Danelle Stevens-Watkins, Brittany Miller-Roenigk, Christopher K. Marshburn, Myles Moody

Psychology Faculty Publications

At the intersection of race and gender, Black men encounter conflicting and often stress-inducing gender norms. Research suggests Black men may utilize John Henryism Active Coping (JHAC), a culturally-relevant strategy to manage stress. However, little is known about how incarcerated Black men cope with gender role conflict (GRC) and resulting psychological distress. To better understand stressors and coping strategies among Black male prisoners, the current study examined the relationships between GRC, anxiety, and JHAC among N = 193 incarcerated Black men nearing community reentry. Hierarchical linear regression results showed length of incarceration, GRC, and anxiety were all negatively associated with …


The Short Executive Function Scale, Justin E. Karr Jan 2024

The Short Executive Function Scale, Justin E. Karr

Psychology Faculty Publications

This study involved a psychometric evaluation of the Short Executive Function Scale (SEFS), a new 15-item self-report questionnaire measuring five constructs: Planning, Inhibition, Working Memory, Shifting, and Emotional Control. Participants included 717 U.S. undergraduate students (M = 18.9 years old, SD = 1.9; 78.8% cisgender female, 81.7% White) who completed the SEFS. A subset of 156 participants (M = 18.8 years old, SD = 0.9; 79.5% cisgender female, 83.3% White) completed the SEFS again at 2- to 3-month retest along with the Behavior Rating Inventory of Executive Function-Adult (BRIEF-A) and the Patient Health Questionnaire (PHQ-8). The five-factor model fit well …


Preliminary Evaluation Of The Scandinavian Guidelines For Initial Management Of Minimal, Mild, And Moderate Head Injuries With Glial Fibrillary Acidic Protein, Mira Keski-Pukkila, Justin E. Karr, Jussi P. Posti, Ksenia Berghem, Anna Kerttu Kotilainen, Kaj Blennow, Henrik Zetterberg, Grant L. Iverson, Teemu M. Luoto Jan 2024

Preliminary Evaluation Of The Scandinavian Guidelines For Initial Management Of Minimal, Mild, And Moderate Head Injuries With Glial Fibrillary Acidic Protein, Mira Keski-Pukkila, Justin E. Karr, Jussi P. Posti, Ksenia Berghem, Anna Kerttu Kotilainen, Kaj Blennow, Henrik Zetterberg, Grant L. Iverson, Teemu M. Luoto

Psychology Faculty Publications

Glial fibrillary acidic protein (GFAP) has become the most promising biomarker for detecting traumatic abnormalities on head computed tomography (CT) in patients with traumatic brain injury (TBI), but most studies have not addressed the potential added value of combining the biomarker with clinical variables that confer risk for intracranial injuries. The Scandinavian Guidelines for Initial Management of Minimal, Mild, and Moderate Head Injuries in Adults were the first clinical decision rules in the field with an incorporated biomarker, the S100 astroglial calcium-binding protein B (S100B), which is used in the Mild (Low Risk) group defined by the guidelines. Our aim …


Assessing Reliability For Quantifying Social Interactions Among Crayfish, Lee Ann Smith, Jeremy Nadolski, Grace Jacobs, Jodi M. Ogle, Madhusudan P. Srinivasan, Hannah N. Tanner, Elizabeth R. Steele, Nicole T. Marguerite, Sonya Bierbower, Slane Steen, Isaac Easterling, Abigail Greenhalgh, Cecilia Pankau, Shelby Mccubbin, Brad Behymer, Robin L. Cooper Jan 2024

Assessing Reliability For Quantifying Social Interactions Among Crayfish, Lee Ann Smith, Jeremy Nadolski, Grace Jacobs, Jodi M. Ogle, Madhusudan P. Srinivasan, Hannah N. Tanner, Elizabeth R. Steele, Nicole T. Marguerite, Sonya Bierbower, Slane Steen, Isaac Easterling, Abigail Greenhalgh, Cecilia Pankau, Shelby Mccubbin, Brad Behymer, Robin L. Cooper

Psychology Faculty Publications

Animal behavior is a useful way to evaluate the environment and can be a predictive tool to assess not only the effects of treatments in a laboratory setting, but also the status of ecological habitats. As invasive species of crayfish encroach on territories of native species, the social behaviors and interactions can be informative for ecological studies. For a wider and more impactful effect, training community scientists using a scoring system to record the social interactions of crayfish that includes both the level of aggression and intensity would provide useable data to monitor the environment. Amateur scientists with little training …


Cerebrovascular Disease Is Associated With Alzheimer's Plasma Biomarker Concentrations In Adults With Down Syndrome, Natalie C. Edwards, Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa E. Petersen, Sid O'Bryant, Lisi Flores Aguilar, Sabrina Simoes, Mark Mapstone, Dana L. Tudorascu, Shorena Janelidze, Oskar Hansson, Benjamin L. Handen, Bradley T. Christian, Joseph H. Lee, Florence Lai, H. Diana Rosas, Shahid Zaman, Ira T. Lott, Michael A. Yassa, José Gutierrez, Donna M. Wilcock, Elizabeth Head, Adam M. Brickman, Howard J. Aizenstein, Beau M. Ances Jan 2024

Cerebrovascular Disease Is Associated With Alzheimer's Plasma Biomarker Concentrations In Adults With Down Syndrome, Natalie C. Edwards, Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa E. Petersen, Sid O'Bryant, Lisi Flores Aguilar, Sabrina Simoes, Mark Mapstone, Dana L. Tudorascu, Shorena Janelidze, Oskar Hansson, Benjamin L. Handen, Bradley T. Christian, Joseph H. Lee, Florence Lai, H. Diana Rosas, Shahid Zaman, Ira T. Lott, Michael A. Yassa, José Gutierrez, Donna M. Wilcock, Elizabeth Head, Adam M. Brickman, Howard J. Aizenstein, Beau M. Ances

Psychology Faculty Publications

By age 40 years, over 90% of adults with Down syndrome have Alzheimer's disease pathology and most progress to dementia. Despite having few systemic vascular risk factors, individuals with Down syndrome have elevated cerebrovascular disease markers that track with the clinical progression of Alzheimer's disease, suggesting a role of cerebrovascular disease that is hypothesized to be mediated by inflammatory factors. This study examined the pathways through which small vessel cerebrovascular disease contributes to Alzheimer's disease-related pathophysiology and neurodegeneration in adults with Down syndrome. One hundred eighty-five participants from the Alzheimer's Biomarkers Consortium-Down Syndrome [mean (SD) age = 45.2 (9.3) years] …