Digital Commons Network^™

Examination Of Mgmt As A Risk Gene For Dementia In The Amish, Leighanne R. Main, Yeunjoo E. Song, Audrey Lynn, Renee A. Laux, Kristy L. Miskimen, Michael D. Osterman, Paula K. Ogrocki, Alan J. Lerner, M. Denise Fuzzell, Sarada L. Fuzzell, Sherri D. Hochstetler, Jonathan L. Haines

Researchers, Instructors, & Staff Scholarship

INTRODUCTION: Recently, the O-6-methylguanine-DNA methyltransferase (MGMT) locus was proposed as influencing the risk of Alzheimer's disease (AD) in women who did not carry the apolipoprotein E ε4 allele. We examined an Amish founder population for any influence of genetic variation in and around the MGMT locus on the risk for dementia. METHODS: Genetic association was performed for single nucleotide polymorphisms (SNPs) surrounding the MGMT locus. A total of 946 individuals of Amish descent between the ages of 76 and 95 who were classified as cognitively impaired or cognitively unimpaired were included. Multiple statistical models were applied to test for replication. …

Evaluation Of Impact Energy In Composites Using Acoustic Emission Sensing Technique, Li Ai, Tanner Mesaric, Sydney Flowers, Sydney Houck, Joshua Widawsky, Paul Ziehl

Faculty Publications

A major challenge faced by composite materials is impact, which can result in unexpected damage and degradation. Impact events can cause significant structural damage that may not be immediately visible, leading to a reduction in the material’s mechanical properties and overall performance. This paper presents an impact assessment method using acoustic emission (AE) sensing technology. The primary goal of this approach is to determine the extent of impact damage on composite components by analyzing AE signals produced under operating stress conditions. An advanced algorithm is proposed to predict the probability that the damage falls into various damage categories, providing a …

Importance Of The Hemoglobin Glycation Index For Risk Of Cardiovascular And Microvascular Complications And Mortality In Individuals With Type 2 Diabetes (Endocrinol Metab 2024;39:732-47, Claudia Regina Lopes Cardoso Et Al.), Stuart A. Chalew

School of Medicine Faculty Publications

No abstract provided.

Reconstructing Superoscillations Buried Deeply In Noise, Derek D. White, Shunxing Zhang, Barbara Šoda, Achim Kempf, Daniele C. Struppa, Andrew N. Jordan, John C. Howell

Mathematics, Physics, and Computer Science Faculty Articles and Research

We utilize a method using frequency combs to construct waves that feature superoscillations—local regions of the wave that exhibit a change in phase that the bandlimits of the wave should not otherwise allow. This method has been shown to create superoscillating regions that mimic any analytic function—even ones well outside the bandlimits—to an arbitrary degree of accuracy. We experimentally demonstrate that these waves are extremely robust against noise, allowing for accurate reconstruction of a superoscillating target function thoroughly buried in noise. We additionally show that such a construction can be easily used to range-resolve a signal well below the commonly …

Optimizing Transport Predictive Modeling With Simulation-Based Statistical Inference Authors, Mamunur Rashid, Quyen Tran

Mathematics Faculty Publications

Simulation-based statistical inference (SBI) leverages computer simulations to help scientists understand and analyze complex data. This paper explores how SBI techniques can be used to analyze transportation data. We use modern computational methods, including machine learning models, to improve the accuracy of predictions and decision-making in transportation planning. Our study focuses on two SBI methods, Approximate Bayesian Computation - Markov Chain Monte Carlo and Synthetic Likelihood, to create synthetic data for training machine learning models. These models show the potential of SBI to handle uncertain transportation data. It also highlights the practical benefits of SBI in making better decisions for …

When Little Beings Are Celebrated With Gentle, Healing Hands: The Role Of Homoeopathy In Shaping A Healthier Generation, Subhash Kaushik

Indian Journal of Research in Homoeopathy

Editorial

Lateral Venous Ulcer Treated With Homoeopathy Using A Miasmatic Approach – A Case Report, Karunakara Moorthi, Reshma P

Indian Journal of Research in Homoeopathy

Introduction: Loss of all or a portion of the dermis, as well as the epidermis, causes an open sore known as an ulcer. Venous leg ulcers are late signs of venous hypertension and chronic venous insufficiency. Long-term ulcers are difficult to heal and lastly opted for skin grafting and surgery conventionally. This case report provides insight into the treatment of venous ulcer with homoeopathy using the miasmatic approach and helps to provide evidence for further research in this area.

Case Summary: A 61-year-old female presented with ulceration near the lateral malleolus of her left leg for the past 6 years. …

Managing The Cost Of Services For People With Disabilities: An International Approach. Part I: Poland, Dana Pugh, Jaroslaw Richard Romaniuk

Faculty Scholarship

Introduction: The cost of care for people with disabilities is rising, whereas all forms of support for them are decreasing. Countries and communities develop different ways to serve the disabled. We examined the comprehensive state of care from the perspective of cost management of services for individuals with disabilities in Poland. Method: This paper is based on a review of relevant international literature, with a special focus on the situation in Poland. A keyword search was completed in both Polish- and English-language databases. Results: In Poland, people with disabilities usually live with their families, and specialized services are offered outside …

Highway Crossing Rates Of Wild Felids Before, During, And After Wildlife Crossing Structure Installation, Sarah E. Lehnen, Mitch Sternberg, Hilary M. Swarts, John H. Young Jr., Victoria Hanley, Richard J. Kline

School of Earth, Environmental, & Marine Sciences Faculty Publications

In an environment increasingly dominated by roads, wildlife crossing structures (WCS) have been installed to decrease wildlife mortality and improve habitat linkages. In South Texas, vehicle collisions have been a major mortality source for the endangered ocelot ( Leopardus pardalis ). To mitigate threats to this species, eight WCS, along with associated fencing, were strategically placed along Farm‐to‐Market Road 106 (FM106), which passes through ocelot habitat. We assessed the rate of on‐roadway crossings and WCS use by GPS‐collared animals before, during, and after WCS installation using camera traps to verify WCS use. Because of the rarity of ocelots in this …

In Situ Preparation Of Silver Nanoparticles/Organophilic-Clay/Polyethylene Glycol Nanocomposites For The Reduction Of Organic Pollutants, Amina Sardi, Bouhadjar Boukoussa, Aouicha Benmaati, Kheira Chinoune, Adel Mokhtar, Mohammed Hachemaoui, Soumia Abdelkrim, Issam Ismail, Jibran Iqbal, Shashikant P. Patole, Gianluca Viscusi, Mohamed Abboud

All Works

This work focuses on the preparation and application of silver nanoparticles/organophilic clay/polyethylene glycol for the catalytic reduction of the contaminants methylene blue (MB) and 4-nitrophenol (4-NP) in a simple and binary system. Algerian clay was subjected to a series of treatments including acid treatment, ion exchange with the surfactant hexadecyltrimethylammonium bromide (HTABr), immobilization of polyethylene glycol polymer, and finally dispersion of AgNPs. The molecular weight of polyethylene glycol was varied (100, 200, and 4000) to study its effect on the stabilization of silver nanoparticles (AgNPs) and the catalytic activity of the resulting samples. The results showed that the catalyst with …

Dental Clinic Deserts In The Us: Spatial Accessibility Analysis, Md Shahinoor Rahman, Jeffrey C. Blossom, Ichiro Kawachi, Renuka Tipirneni, Hawazin W. Elani

School of Public Health Faculty Publications

IMPORTANCE: Little is known about the spatial accessibility to dental clinics across the US. OBJECTIVE: To map the spatial accessibility of dental clinics nationally and to examine the characteristics of counties and US Census block groups with dental care shortage areas. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional study of US dental clinics in 2023 using data from the IQVIA national practitioners' database, which includes 205 762 active dentists. Data were analyzed from November 2023 to April 2024. EXPOSURES: Socioeconomic characteristics of block groups and counties including rurality, area deprivation, racial and ethnic segregation, and uninsured population. MAIN OUTCOMES AND MEASURES: Enhanced …

Impact Of Inquiry-Based Stress Reduction Intervention On Pharmacy Students’ Test Anxiety, Martha Ndung’U, Suzanne Galal, Emily Tran, Matissa Peng, Jeffrey Chang, Deepti Vyas, John Mayberry, Avneet K. Chima

Pacific Faculty Work

Test anxiety is a significant issue among pharmacy students, potentially affecting their academic performance and well-being. This study aimed to evaluate the effectiveness of an Inquiry-Based Stress Reduction (IBSR) intervention in reducing test anxiety. Pharmacy students enrolled in a didactic course were randomized into an IBSR intervention group or a control group. Both groups attended a 1.5 h seminar; the intervention group learned the IBSR technique, while the control group received instruction on an unrelated topic (emotional intelligence). The intervention group also submitted weekly self-reflections on applying IBSR to exam-related anxiety. Anxiety levels were measured using the State-Trait Anxiety Inventory …

Role Of Homoeopathic Medicine In The Management Of Psoriasis – An Evidence-Based Case Report, Priya Bablesh Chaurasiya, Priya Gauri A. Chaphekar, Sailee V. Ingale

Indian Journal of Research in Homoeopathy

Introduction: Psoriasis is a common chronic, recurrent, immune-mediated disease, where plaque-type psoriasis and psoriatic arthritis show 90 % and 7% prevalence, respectively. It is a cosmetically expressed condition that impacts the individual and the family, thus affecting quality of life. It impacts the physical, emotional and psychosocial well-being of the sick individual. It accounts for up to 3% of the World’s population. Although this condition is not life-threatening, it is challenging to treat due to the lack of established causative factors. Conventional medicine offers long-term treatment with a short-term benefit to patients with psoriasis, resulting in discontinued treatment by the …

Research Highlights, Swati Kharb, Purnima Rani

Indian Journal of Research in Homoeopathy

Research Highlights

Celebrating World Homoeopathy Day With A Homoeopathic Symposium On Empowering Research, Enhancing Proficiency, Babita Rani Kondle, Divya Taneja, Renu Mittal, Subhash Kaushik

Indian Journal of Research in Homoeopathy

The Honourable President of India, Smt. Droupadi Murmu inaugurated the scientific convention ‘Empowering Research Enhancing Proficiency: A Homoeopathic Symposium’ on 10th and 11th April 2024 at Yashobhoomi (India International Convention and Expo Centre), New Delhi, India. The convention which was jointly organised by the Central Council for Research in Homoeopathy, National Commission for Homoeopathy and National Institute of Homoeopathy under the aegis of the Ministry of Ayush, Government of India to commemorate the 269th birth anniversary of Dr. Christian Friedrich Samuel Hahnemann. There were a total of 17 sessions which included five panel discussions. The convention was attended by more …

Global Prevalence Of Helicobacter Pylori Antibiotic Resistance Among Children In The World Health Organization Regions Between 2000 And 2023: A Systematic Review And Meta-Analysis, Aryan Salahi-Niri, Ali Nabavi-Rad, Tanya Marie Monaghan, Theodore Rokkas, Michael Doulberis, Amir Sadeghi, Mohammad Reza Zali, Yoshio Yamaoka, Evelina Tacconelli, Abbas Yadegar

Faculty, Staff and Students Publications

Background: Helicobacter pylori infection causes gastritis, peptic ulcers, and gastric cancer. The infection is typically acquired in childhood and persists throughout life. The major impediment to successful therapy is antibiotic resistance. This systematic review and meta-analysis aimed to comprehensively assess the global prevalence of antibiotic resistance in pediatric H. pylori infection.

Methods: We performed a systematic search of publication databases that assessed H. pylori resistance rates to clarithromycin, metronidazole, levofloxacin, amoxicillin, and tetracycline in children. The WHO region classification was used to group pooled primary and secondary resistance estimates along with 95% confidence interval (CI). H. pylori antibiotic resistance rates …

Editors' Introduction

Genocide Studies and Prevention: An International Journal

No abstract provided.

After Impunity: The Anti-Impunity Norm, The Colombian Special Jurisdiction For Peace, And The Future Of International Criminal Law, Max Pensky

Genocide Studies and Prevention: An International Journal

The predominance of international criminal law as a frontline response to atrocity crimes prioritizes the countering of impunity as an overarching goal. A corresponding “anti-impunity norm” identifies the legal punishment of individual perpetrators as a core requirement in legal responses to atrocities. This anti-impunity norm – the requirement to prosecute and punish – is also a legal obligation for state parties to the International Criminal Court. But the anti-impunity norm equates impunity’s opposite – accountability – with the imposition of legal punishment. This narrow interpretation of impunity places limits on states’ ability to craft context-specific responses to atrocities while also …

Beyond Hierarchy: Investigating The Role Of Complex-Fluid Structures In The Accountability Of Criminal Organizations, María Manuela Márquez Velásquez, Rodrigo Moreno

Genocide Studies and Prevention: An International Journal

Globalization and technological development have led to quick transformations in criminal organizations, adapting to new forms/degrees of control and hierarchy. Existing legal frameworks governing responsibility for atrocity crimes have developed from the experiences of Western (center) countries and their understanding of traditional warfare structures. Thus, peripheral regions have been forced to employ doctrines with weak sociological basis. New and conventional local dynamics inside organizations and their consequential fluidity challenge the applicability of traditional modes of liability when seeking their members’ accountability.

This paper inquires about the suitability of two modes of liability under ICL –perpetration through an organization and superior …

Assembling Pieces Of Accountability For The Srebrenica Genocide, Annick Pijnenburg, Nataša Nedeski

Genocide Studies and Prevention: An International Journal

The Srebrenica genocide has been the subject of multiple legal proceedings against various actors before different courts, at both the national and international level. Amongst others, the International Criminal Tribunal for the Former Yugoslavia has sentenced various individual perpetrators, the International Court of Justice has ruled on the responsibility of the Serbian state, and Dutch courts have been asked to rule on the liability of the Dutch state and the United Nations. This raises the following question: to what extent have multiple adjudicatory mechanisms across legal regimes managed to deliver accountability for the Srebrenica genocide and what are the remaining …

If Only Justice Could Heal Or Make Whole: Hard Lessons From Rwanda’S Legal Responses To Genocide And Mass Atrocity, Gerald Gahima

Genocide Studies and Prevention: An International Journal

My reflections on the limits of legal responses in Rwanda stem from both academic and lived experience. I served as Rwanda’s Deputy Minister of Justice (1996–1999), Prosecutor General (1999–2003), and Deputy Chief Justice (2003–2004) during the period after the genocide. In those roles, I had access to a large volume of information drawn from policy- making roles, case files of members of my staff, as well as my own fieldwork relating to the suffering of victims of the genocide. While I obviously believe that justice for those crimes is not in vain, my work with survivors left me with an …

Global Human Rights Sanctions: How Can They Contribute To Addressing Mass Atrocities?, Yifan Jia

Genocide Studies and Prevention: An International Journal

Global Human Rights Sanctions (GHRS) have been used in over 30 countries as a mechanism for imposing unilateral human rights sanctions on individual perpetrators. Despite the hundreds of specific sanctions that have been imposed globally, there remains a lack of understanding about how these measures function on gross human rights violations. This article seeks to explore how GHRS, as an emerging human rights mechanism, contributes to addressing mass atrocities. I categorize the functions of GHRS into two phases: post-atrocity and pre-atrocity. In the post-atrocity phase, I identify three primary objectives asserted by sanctioning states: punishing perpetrators, promoting behavioral change, and …

Evaluating The Impact Of A Novel Program To Address Acute Food Insecurity Among Cancer Patients, Elliott M. Sina, Michael Rowe, Gina Mancuso, Gregory Garber, W. Kevin Kelly, Amy E. Leader

Kimmel Cancer Center Faculty Papers

INTRODUCTION: Acute food insecurity (FI) significantly impacts cancer patients' health, exacerbating physical and psychological burdens. While current interventions address chronic FI, acute cases remain undermanaged. Legacy of Hope, a Philadelphia-based non-profit, addresses this gap through its Emergency Patient Support Network (EPSN), offering free bi-weekly groceries to patients facing acute FI.

MATERIALS AND METHODS: The pilot study evaluated EPSN's impact utilizing the Legacy of Hope Acute Food Insecurity (LOHAFI) survey, which was performed at baseline and two weeks post-intervention. The survey combines the Functional Assessment of Cancer Therapy-General (FACT-G7) and questions on food and financial security. Mean scores and frequencies were …

Racism, Depression, And The Superwoman Schema: A Narrative Inquiry With Fourth-Grade Black Girls, Athena Hall

Walden Dissertations and Doctoral Studies

In the United States, racism has been labeled a public health emergency. Amid rising rates of racism reported in schools, many Black girls aged 5 to 12 have severe and persistent symptoms of depression. Although Woods-Giscombé’s Superwoman Schema (SWS) is an acknowledged coping mechanism that Black women and adolescent girls can use to fight and transcend interconnected systems of racial and gender oppression, it has rarely been studied among pre-adolescent girls. The purpose of this qualitative narrative inquiry was to explore the lived experience of the SWS among fourth-grade Black girls in Detroit, Michigan. The theoretical framework was the SWS. …

Editorial: Infrastructure Maintenance And Monitoring For Sustainable Cities, Yonas Kassa, Saeed Eftekhar Azam, Deepak Khazanchi, Brian Ricks

Faculty Publications

As cities continue to grow and evolve, maintaining and monitoring their infrastructure becomes an 2 increasingly challenging problem, requiring multidisciplinary approaches. This problem is as critical for 3 developing countries that are rapidly building their infrastructure (Gurara et al., 2018Ede et al., 2019) 4 as it is for already developed countries with aging infrastructure (Van Breugel, 2017). Researchers have 14 Such developments can also be integrated into digital twinning-a technology approach that creates 15 virtual replicas of physical infrastructure elements, systems, and cities-that offers a dynamic framework 16 for real-time monitoring and predictive maintenance through data integration and simulation. The …

Researcher As Insider: Bringing Together Narrative Therapy Practices And Feminist Lived Experience Methodologies In The Context Of Suicide Research, Marnie Sather

The Qualitative Report

This paper contains a demonstration of the value of feminist insider research. Through bringing together principles of feminist insider research, narrative therapy theory and practice, and my positionality as a researcher, a narrative therapist, and a woman who lost her husband to suicide, I developed a research methodology that was sensitive and effective in exploring the lived experiences and insider knowledge of women who have lost a male partner to suicide. Careful utilisation of my insider positionality benefited the research in multiple ways, from recruitment and care of participants to data analysis and knowledge production, to the generation of research …

Resisting Ableism In Research Design, Gipsy Hosking

The Qualitative Report

This paper explores how ableist assumptions can unintentionally create barriers to participation in research by those of non-normative bodies or minds. In traditional epistemology, bodies are considered “universal” rather than “specific,” and the universal body is coded as fully able-bodied and independent with brain and body adhering to normative standards of the White heterosexual English-speaking male. In this article, I present a story of “enabling participation” for those of diverse body capacity in my work with young women living with chronic illness.^[1]Specifically, I explore the accommodations and adaptions I made to my research design to account for the …

Narrative Engineering: Tools, Computational Structure, And Impact Of Stories, Michael A. Debuse

Theses and Dissertations

Computational Linguistics has a long history of applying mathematics to the grammatical and syntactic structure of language; however, applying math to the more complex aspects of language, such as narrative, plot, scenes, character relations, causation, etc. remains a difficult topic. The goal of my research is to bridge the narrative humanities with mathematics, to computationally grasp at these difficult topic, and help develop the field of Narrative Engineering. I view narrative and story with the same mathematical scrutiny as other engineering fields, to take the creativity and fluidity of story and encode it in mathematical representations that have meaning beyond …

Revisiting Insider Practices: Ethical Considerations, Practices, And Hopes For Doing Community Work And Narrative Research In And About Our Own Communities, Tiffany Sostar, Nathan Viktor Fawaz, Elliot Trimble, Theodosia Octavia Markarian, Bekett Noble

The Qualitative Report

In this paper, we describe the hopes, considerations, and questions of a narrative practice research collaboration among three closely connected transgender (trans) and/or non-binary collaborators, in a collection of work meant to support trans, non-binary, and gender expansive life and in response to trans death at a time of increasing hostility toward trans communities. We apply a specific focus on inquiring into how to do narrative therapy and community work research in and about our own communities, and what the ethical, relational and methodological practices for this work might be. We do this through reflecting on existing literature related to …

A Phase 1 Randomized Trial Of Homologous And Heterologous Filovirus Vaccines With A Late Booster Dose, Christina A Rostad, Carol Kao, Et Al.

2020-Current year OA Pubs

Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple filoviruses is a high global health priority. In this Phase 1 trial, we enrolled 60 healthy U.S. adults and evaluated the safety, reactogenicity and immunogenicity of homologous and heterologous MVA-BN®-Filo and Ad26.ZEBOV prime-boost schedules followed in select arms by MVA-BN®-Filo boost at 1 year (NCT02891980). We found that all vaccine regimens had acceptable safety and reactogenicity. The heterologous prime-boost strategy elicited superior Ebola binding and neutralizing antibody, antibody-dependent cellular cytotoxicity …