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Corpus Linguistics At The U.S. Patent And Trademark Office, Tabrez Y. Ebrahim

BYU Law Review

This Article examines the intersection of corpus linguistics and patent law. It introduces the foundations of corpus linguistics and its application to the law and advances the potential for its application to patent examination at the United States Patent and Trademark Office (USPTO). Historically, the disciplines of corpus linguistics and patent law did not intersect until scholars began to consider the application of corpus linguistics to patent litigation for interpretation of terms in patent claims. Interpretation of legal language provided by corpus linguistics and applied to patent examination at the USPTO has yet to be addressed and is a novel …

Impact Of Site-Specific Conjugation Strategies On The Pharmacokinetics Of Antibody Conjugated Radiotherapeutics, Ábel Nagy, David Ulmert, Wahed Zedan, Claire M Storey, Julie Park, Susanne Geres, Katharina Lückerath, Kjell Sjöström, Hadis Westin, Norbert Peekhaus, Daniel Lj Thorek, Amelie Eriksson Karlström, Mohamed Altai

2020-Current year OA Pubs

Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been developed in recent years for toxin- and fluorophore-mAb conjugates. In this study, we studied two site-specific labelling strategies for the conjugation of the macrocyclic chelating agent, DOTA, to the anti-Leucine Rich Repeat Containing 15 (LRRC15) mAb DUNP19. Specifically, one approach utilized a DOTA-bearing peptide (FcIII) with a strong affinity for the fragment …

Mrs. Lucille Stidem Hill

African American Funeral Programs

Mrs_Lucille_Stidem_Hill.pdf - Funeral program for Lucille Hill

Johnny Lee Rawls

African American Funeral Programs

Johnny_Lee_Rawls.pdf - Funeral program for Johnny Lee Rawls

A Practical Clinical Approach To Navigate Pulmonary Embolism Management: A Primer And Narrative Review Of The Evolving Landscape, Kevin Benavente, Bradley Fujiuchi, Hafeez Ul Hassan Virk, Pavan K Kavali, Walter Ageno, Geoffrey D Barnes, Marc Righini, Mahboob Alam, Rachel P Rosovsky, Chayakrit Krittanawong

2020-Current year OA Pubs

Advances in imaging, pharmacological, and procedural technologies have rapidly expanded the care of pulmonary embolism. Earlier, more accurate identification and quantification has enhanced risk stratification across the spectrum of the disease process, with a number of clinical tools available to prognosticate outcomes and guide treatment. Direct oral anticoagulants have enabled a consistent and more convenient long-term therapeutic option, with a greater shift toward outpatient treatment for a select group of low-risk patients. The array of catheter-directed therapies now available has contributed to a more versatile and nuanced armamentarium of treatment options, including ultrasound-facilitated thrombolysis and mechanical thrombectomy. Research into supportive …

Modelling V-Band Atmospheric Loss With Deep Learning, Ralph Lyndon Gesner

Electrical and Computer Engineering ETDs

Modelling atmospheric loss is fundamental to implementation of future mm-wave terrestrial and earth space communication links. Atmospheric losses have traditionally been estimated by calculating the contributions of individual weather phenomena through in-situ meteorological measurements and statistically derived models for estimating localized atmospheric water content. Collecting data for all points along the propagation path and calculating the physical effects of gases, clouds, and precipitation individually is both time consuming and impractical for large-scale use cases.

In response to these present limitations, this work proposes the use of novel deep learning models for estimating atmospheric losses from tabular meteorological sensor data and …

Cost-Effectiveness Analysis Of Pembrolizumab With Chemotherapy For Metastatic Nonsquamous Non-Small Cell Lung Cancer In Taiwan, Wei-Ling Lee, Wan-Hsuan Chou, Wei-Pin Chang, Tsung-Wei Chang, Chun-Nan Kuo, Wei-Chiao Chang

Journal of Food and Drug Analysis

This study was aimed to evaluate the cost-effectiveness of pembrolizumab with chemotherapy (pembrolizumabcombination therapy) and compare it with standard-of-care platinum-based chemotherapy (chemotherapy alone) as a first-line treatment for metastatic nonsquamous NSCLC from the perspective of Taiwan's third-party-payer public health-care system. We used a partitioned survival model with an estimated time horizon of 10 years. The partitionedsurvival model uses KaplaneMeier estimates of progression-free and overall survival from the KEYNOTE-189 clinicaltrial. The quality-adjusted life-year (QALY) values were based on utility values by progression status calculated from theKEYNOTE-189 trial. This study examined costs related to treatment regimens, disease management, second-line therapy,end-of-life care, and …

Aromatic Compounds And Organic Acids Identified From Ganoderma Formosanum Exhibit Synergistic Anti-Melanogenic Effects, Chen-Che Hsieh, Chih-Yao Hou, Hsiao-Yun Lei, Darin Khumsupan, Huey-Jine Chai, Pek-Kui Lim, Cheng-Chih Hsu, Sz-Jie Wu, Kai-Wen Cheng, Yi-Chen Chen, Kuan-Chen Cheng

Journal of Food and Drug Analysis

This study reveals the anti-tyrosinase activity of Ganoderma formosanum extracts, pinpointing compounds including gluconic acid, mesalamine, L-pyroglutamic acid, esculetin, 5-hydroxyindole, and salicylic acid, as effective melanin production inhibitors in melanoma cells and zebrafish embryos. Furthermore, multiple molecular docking simulations provided insights into interactions between the identified compounds and tyrosinase, increasing binding affinity up to -16.36 kcal/mol. The enhanced binding of identified compounds to tyrosinase facilitated synergistic inhibitory effects on melanin production. This study highlights the potential of GFE-EA as a source of natural tyrosinase inhibitors and contributes to understanding the role of active compounds extracted from G. formosanum.

Bitter Acids From Humulus Lupulus L. Alleviate D-Galactose Induced Osteoblastic Senescence And Bone Loss Via Regulating Akt/Mtor-Mediated Autophagy, Tian-Shuang Xia, Sheng-Yan Xu, Li-Yong Lai, Yi-Ping Jiang, Na-Ni Wang, Hai-Liang Xin

Journal of Food and Drug Analysis

Bitter acids (BA) are main component of Humulus lupulus L. (hops). They are known for beer brewing and have various biological and pharmacological properties, especially the bone-protective effect confirmed by our previous in vivo study. Here we aimed to elucidate the anti-senior osteoporosis (SOP) effect of BA on osteoblasts and explore its underlying mechanism. In vitro SOP model was established by D-galactose (D-gal) injured osteoblasts, and the bone formation markers and apoptosis level were measured. mCherry-EGFP-LC3 adenovirus infection and autophagic markers including beclin1 and LC3 proteins were detected to investigate the autophagy level in osteoblasts. To further verify whether BA …

Development And Industrial Application Of Geographical Origin Identification For Taiwanese Oolong Tea, Tien-Lin Liu, Jia-Ru Dai, Tsung-Chen Su, Chun-Huo Chiu, Hsien-Tsung Tsai, Chui-Feng Chiu, Jin-Chih Lin, Chih-Yi Hu

Journal of Food and Drug Analysis

Taiwanese oolong tea is renowned for its excellent quality and enjoys a prestigious reputation both domestically and internationally. In recent years, there has been an issue with imported Taiwanese-style oolong tea being sold as genuine Taiwanese oolong tea, which has adversely affected the brand value of Taiwanese oolong tea. In this study, samples of domestic oolong tea (Taiwanese oolong tea) and Taiwanese-style oolong tea produced abroad (including China, Vietnam, Indonesia, Thailand, etc.) were collected. A multi-elements analysis method was applied to establish an elemental database of tea leaf samples. Subsequently, various widely used classification methods were employed to develop a …

Determination And Validation Of Polycyclic Aromatichydrocarbons (Pah4) In Katsuobushi, Plant-Basedfood Supplements, And Cocoa Bean Shells Using Gc-Ms/Ms, Chia-Hsin Liu, Yu-Ning Shin, Ya-Chun Chou, Guan-Jhih Peng, Ying-Ru Shen, Nu-Ching Lin, Shu-Han Chang, Ya-Min Kao, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

Polycyclic aromatic hydrocarbons (PAHs) are primarily generated through the incomplete combustion or pyrolysis oforganic materials in various industrial processes. Foods may become contaminated with environmental PAHs found inair, soil, or water, or through industrial food processing methods such as smoking, roasting, drying, and grilling. The Ministry of Health and Welfare in Taiwan has established maximum levels for benzo[a]pyrene (BaP) and indicativevalues for BaP as well as PAH4 (the sum of benz[a]anthracene, chrysene, benzo[b]fluoranthene, and benzo[a]pyrene) infoods as operational guidelines. The current study developed an analytical method for simultaneous determination of PAH4 levels in katsuobushi (dried bonito flakes), cocoa bean shells, …

Herbal Nanoemulsions In Cosmetic Science: A Comprehensive Review Of Design, Preparation, Formulation, And Characterization, Benni Iskandar, Ta-Wei Liu, Hui-Ching Mei, I-Chih Kuo, Meircurius Dwi Condro Surboyo, Hsiu-Mei Lin, Ching-Kuo Lee

Journal of Food and Drug Analysis

The rapid development of delivery systems for cosmetics has revealed two critical challenges in the field: enhancing the solubility of active ingredients and ensuring the stability of natural materials used in cosmetics. Nanoemulsion technology has emerged as an indispensable solution for addressing these challenges, not only enhancing the stability of cosmetics but also improving the solubility of pharmaceuticals and active ingredients with poor solubility. Nanoemulsion formulations have reinforced stability and amended the bioavailability of hydrophobic drugs. Moreover, nanoemulsion exhibit excellent skin penetration and long-lasting effects, making them particularly appealing to consumers, especially in the cosmetic industry. This article aims to …

Therapeutic Approach Of Carbon Nanotube: Revolutionize Nanomaterial In Biomedical And Pharmaceutical Sector, Shovan Ghosh, Vivek Dave, Pranay Wal

Journal of Food and Drug Analysis

Carbon nanotubes (CNTs) has emerged as a promising nanomaterial with a wide range of potential applications due to their unique structural, mechanical, electrical, and thermal properties. However, numerous obstacles must be overcome for CNTs to be used successfully, including low solubility, aggregation, and a lack of specialized functions. Diverse techniques have been developed for the manufacture, purification, and functionalization of CNTs in order to overcome these issues. The main aim of this review article is to provide brief knowledge about CNTs and strategies to use this revolutionized nanomaterial in drug delivery. Prepare CNTs cannot be directly used as drug carrier …

Updates On The Conversion Of Nanosuspensions To Solid Oral Dosage Forms, Anastasia Tsiaxerli, Elisavet Vardaka, Christos Moutroupidis, Kevin M.G. Taylor, Kyriakos Kachrimanis, Maria Malamatari

Journal of Food and Drug Analysis

Pharmaceutical nanosuspensions, also called nanocrystals, are heterogeneous mainly aqueous dispersions of insoluble drug particles stabilised by surfactants and/or polymers. Nanosuspensions as liquid formulations suffer from instability. Solidification of nanosuspensions to solid dosage forms is a way to combine the advantages of nanocrystals with the advantages of the solid state. In this review, advances regarding stabilisation and production of nanosuspensions are briefly covered. Updates on the methods used to convert nanosuspensions to solid oral dosage forms (e.g., powder, granules, pellets, tablets, and films) are presented in depth. From these methods, spray drying and freeze drying are widely used. Granulation and hot-melt …

Mechanobactericidal Nanotopographies For Food Industry: A Promising Strategy For Eradicating Foodborne Pathogens - Progress And Challenges, Deepak Patil

Journal of Food and Drug Analysis

Nowadays, food preservation, quality maintenance, and safety are major emerging concerns in the food industry. Methods for removing pathogens from the outside surfaces of food products would be an effective way to prevent bacterial contamination. Nanotopographies found on natural surfaces have been shown to mechanically damage the membranes of foodborne bacteria. Thus, using bioinspired mechanobactericidal nanostructures in food packaging and processing materials has the potential to lower surface bacterial contamination while increasing food safety. However, putting this concept into practice remains a challenge. This review discussed recent advances in understanding mechanobactericidal mechanisms, issues concerning the durability of nanotopography under external …

Integrating Image Data Fusion And Resnet Method For Accurate Fish Freshness Classification, Yahya Layth Khaleel, Mustafa Abdulfattah Habeeb, Ghadeer Ghazi Shayea

Iraqi Journal for Computer Science and Mathematics

Fish freshness classification is critical for protecting public health and ensuring efficient economic, regulatory and environmental sustainability. Classifying accurately reduces the risk of foodborne illness, protects product quality, builds consumer trust and supports sustainable resource conservation through waste minimization. However, the traditional methods for determining fish freshness are variable, time consuming and subjective, precluding practical use. This research presents an improved framework that integrates image data fusion and a deep learning ResNet model to differentiate fresh and nonfresh fish. From multiple sources, a comprehensive dataset including 16,640 samples was curated, and data fusion was used to increase the diversity and …

Full Issue, Kritika Kultura

Kritika Kultura

No abstract provided.

Front Matter, Kritika Kultura

Kritika Kultura

No abstract provided.

Okinawa Studies In Taiwan Under Japanese Rule: Focusing On The Use Of The Word “Nantō”, Takahiro Teshima

Kritika Kultura

In the modern period, certain research on Okinawa utilizing the noun “nantō,” which signified the southern islands, was known as Nantō studies. It accentuated Okinawa as the southernmost portion, or one component, of Japan, emphasizing Okinawa’s identity as a place that preserves old Japanese culture, based on the hypothesis that culture originates in the center of a cultural region and spreads to the frontier. This article examines the possibilities and limitations of Nantō studies in colonial Taiwan. Under the academic guidance at Taihoku Imperial University, including Japanese history, which had previously received less attention in prior research, Nantō studies could …

Why Must Japan Be A "Normal Country": Reconsidering Article 9 Of The Japanese Constitution In Inoue Hisashi's Kirikirijin, Te-Gyung Kim

Kritika Kultura

Japan has been pursuing the status of a “normal country” by amending Article 9 of its Constitution, and this long-held desire gained momentum in December 2022 when Kishida Fumio’s cabinet introduced the concept of “counterattack capability.” Considering Japan’s political and historical background, its desire to become a “normal country” should be seriously examined and discussed. As one way of this examination, this article posits that Inoue Hisashi’s Kirikirijin serves as a strategic and critical tool, challenging and subverting Japan’s pursuit of becoming a “normal country.” Notably, the fictional town in the novel, Kirikiri, adopts a constitution almost like Japan’s Article …

Why Should We Care About Care? Popular Care-Narratives And The Dependency Critique, Jay Hee-Jeong Sohn

Kritika Kultura

This essay analyzes representations of care and dependency in popular narratives from the Global North, re-appropriating Eva Feder Kittay’s “dependency critique” as an analytical lens. Through examinations of films like Plan 75, I Care a Lot, The Bacchus Lady, Her, I’m Your Man, and La Maison de Himiko, it explores how these narratives engage with contemporary care issues, including the commodification and gendering of care work, fantasies of automated care, and alternative care models beyond traditional family structures. The analysis reveals how popular culture both reflects and shapes societal attitudes towards care, dependency, and human dignity. By interrogating these representations, …

From Utopian Enclave To Zombified Island: Disaster Capitalism And The Reassertion Of Cuban Identity In Alejandro Brugués’ Juan Of The Dead, Jungwon Park

Kritika Kultura

Cuba, expected with the 1959 revolution to become a utopian enclave in Latin America and beyond, has undergone political and economic hardships since the collapse of the Soviet Bloc, known as the Special Period. However, what has been the fate of this country, which remains one of the most isolated and disconnected in the world, in the twenty-first century? Cuba’s first zombie comedy film, Juan of the Dead (dir. Alejandro Brugués, 2011), depicts the nation’s dystopian present and uncertain future through social criticism, political satire, and burlesque humor. This essay argues that the film’s cannibalistic, infectious zombies allegorize the traumatic …

The Failure Of Community And The Future Of Communitarianism In Asia And Latin America, Alex Taek-Gwang Lee

Kritika Kultura

This article examines the complex dynamics between national identity formation, community transformation, and global crises through multiple theoretical frameworks. Beginning with Kafka’s prescient diary entry about World War I and its resonance with the current Ukraine conflict, the analysis expands to explore Benedict Anderson’s concept of “imagined communities” and its application to postcolonial nation-building in Asia and Latin America. Drawing on Spinoza’s political philosophy, particularly his conception of democracy, I develop a framework for understanding how communities navigate between tradition and modernity in the aftermath of World War II. The research engages with both Anderson’s theory of nationalism and Antonio …

Communication As A Mobile Field: The Critical Dialogue And Exchange Between The Vatican Doctrine On Social Communication And Secular Communication Sciences, Joyce Arriola

Kritika Kultura

The Decree on Social Communication called Inter Mirifica was one of the 16 documents that were produced by the Catholic Church at the Second Vatican Council (1962–1965). It guided the Church in engaging the modern world, particularly through the means of communication. This came at the height of the positivist inflection of communication studies, which began as an academic discipline when the first doctoral program was established in the United States in 1943. While the communication discipline grew steadily as a science, producing its own theories and adopting its specific research methodologies and protocols, it also developed along humanistic lines, …

Filipina Domestic Workers As Contemporary Working-Class Poets: Writing As A Transformative Force, Luka Lei Zhang

Kritika Kultura

In recent years, there has been a surge in the publication of poetry collections written by Filipina domestic workers across various locations, including Singapore, Malaysia, and Hong Kong. Notably, these poets have elected to publish their work through small independent presses, such as Poetry Planet Book Publishing House in the Philippines, rather than the more prevalent trend of migrant worker writings appearing in literary competitions and anthologies. The emergence of these poetry collections represents a unique and timely literary and cultural landscape that merits academic attention. This paper begins by contextualizing them as part of contemporary working-class literature and introducing …

Against Social Abjection: Offred’S Empowering Narration Of The Handmaid's Tale (1985), Saeedeh Esmailzadeh, Maryam Soltan Beyad

Kritika Kultura

This scholarly investigation explores how Offred, the central character in Margaret Atwood’s The Handmaid’s Tale, endeavors to undermine the abjectifying apparatus of Gilead through the utilization of her narrative as a form of resistance. Drawing inspiration from Imogen Tyler’s concept of social abjection, the initial segment of this study will concentrate on the implementation of policies aimed at abjection within the society of Gilead. It will elucidate that the Gileadean regime employs tactics such as fostering disgust consensus, enforcing social hierarchies, propagating territorial stigmatization, and asserting control over language to execute the mechanisms of social abjection. This procedure serves to …

Climate Change And The Construction Of Compromised Agency In Selected Contemporary Fiction, Jessica Murray

Kritika Kultura

As the realities of climate change occupy an increasingly prominent position in all spheres of contemporary societies, the producers of cultural products grapple with these dynamics in their work. Even in texts where the climate and environmental concerns are tangential to the primary narratives, authors of contemporary fiction tend to make at least some passing reference to these dynamics. Fiction offers a space of almost limitless possibilities where writers can offer radically innovative modes of being in a world that is changing at an unprecedented rate due to anthropogenic activities. The construction of agency and the capacity of agents to …

Alikhan Bokeikhan’S Literary Preservation Of Kazakh Identity Against Colonial Ideology, Assem Osken, Dikhan Qamzabekuly, Bekarys Nuriman

Kritika Kultura

In the history of the world, imperialist countries happened to pursue a policy of colonization to destroy ethnic consciousness, culture, language, and knowledge. This article comprehensively analyzes the literary works of the national leader Alikhan Bokeikhan, who opposed the policy of the Russian Empire in the 19th century and its successor, the Soviet government in the 20th century that was aimed at gradually destroying the Kazakh people as a distinct group of Kazakh people. The research shows that literary translations, critical articles, and folklore samples of Bokeikhan greatly contributed to the preservation of Kazakh language, religion, culture, national education and …

Abide With Me: A Social Ecological Perspective In Selected Pandemic Poetry, Amany Abdullah Abdelaziz Eldiasty, Eman Ebeida Mansour

Kritika Kultura

This article traces the core principles of the social ecological approach, namely, the interconnectedness of social communities and their integration into the natural world in selected poems written by contemporary poets during the coronavirus pandemic and collected in Poetry in Response to the Pandemic, published in 2020 by St. Michael’s Episcopal Church in Arlington, VA. Applying a qualitative approach that integrates interpretive and analytical readings of the selected poems based on Daniel Stokols’s views on social ecology, it argues that although social networks facilitated community engagements during the pandemic (particularly during the lockdown), virtual reality failed to sustain the social …

Responses To "Feminism Across Our Generations", Charlie Veric

Kritika Kultura

No abstract provided.