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2024

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When The Right Man Rings Them?, Alan Wayne Cline Jan 2024

When The Right Man Rings Them?, Alan Wayne Cline

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research aims to outline the suitability of Vaughan Williams’s songs to a broader selection of performers, including singers in academic settings and professional musicians around the globe. The significance of Ralph Vaughan Williams's impact on the music world is difficult to question. Among his considerable accomplishments are the editing of the Anglican English hymnal, the advocation for traditional British folk songs as national works of art, the composition of the same number of symphonies as Beethoven and Dvořák, and, most notably for singers, the writing of song cycles and collections of songs. While these accomplishments are significant, his songs …


Choir Teacher Agency And Culturally Sustaining Pedagogy, Kaitlyn Schramm Jan 2024

Choir Teacher Agency And Culturally Sustaining Pedagogy, Kaitlyn Schramm

Graduate Theses, Dissertations, and Problem Reports (ETD)

Culturally sustaining pedagogy (CSP) (Paris, 2012) is an educational framework that nurtures and sustains students’ cultural competencies and identities. Scholars have recognized the need for practices that sustain and nurture cultural identities and ways of knowing music in the music classroom (Abril, 2009; Bond, 2014; Good Perkins, 2018; Salvador & Culp, 2022; Shaw, 2016). Culturally sustaining teachers reimagine curriculum entirely and place students' cultural assets at the center “as targets of learning to be sustained” (Lee, 2017, p. 262), explored, honored, extended, and critically problematized (Lee, 2017; Paris, 2012; Samy Alim et al., 2020). In choral classrooms, this often involves …


Estimating Home Range Size And Density Of White-Tailed Deer (Odocoileus Virginianus) In West Virginia, Sarah M. Pesi Jan 2024

Estimating Home Range Size And Density Of White-Tailed Deer (Odocoileus Virginianus) In West Virginia, Sarah M. Pesi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Big game hunting is an important source of revenue and recreation in the United States. Of big game species, white-tailed deer (Odocileus virginianus) are the most heavily pursued. White-tailed deer are a widespread generalist species, capable of existing at high densities. Hunting is often used as the primary method of managing deer populations, particularly in the eastern United States, where there is a lack of large predators. When populations reach high densities, there can be negative effects on the environment and conflicts with humans. Managers must consider both creating adequate hunting opportunities and reducing negative impacts when managing …


Investigating The Effect Of Using Humorous Threats In Recreation Area Rules Signage To Influence Behavioral Intentions, Jacob Timothy Vargas Jan 2024

Investigating The Effect Of Using Humorous Threats In Recreation Area Rules Signage To Influence Behavioral Intentions, Jacob Timothy Vargas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Communicating the importance of rules and warnings to visitors of recreational parks through signage can be difficult. However, it is one of the most important things to keep visitors safe. Oftentimes, these signs use fear of punishment or injury to discourage certain behaviors. According to studies following the Extended Parallel Processing Model (EPPM), using threats can backfire and cause visitors to use maladaptive fear responses to counteract a threat message if the content is too extreme or too psychologically close. Humor is a versatile tool that can be used to grab attention, temper perceptions, and influence decision-making. Comedians like Jon …


Making Something Out Of Nothing: Immobility As An Operant, KaʻAla K. Bajo Jan 2024

Making Something Out Of Nothing: Immobility As An Operant, KaʻAla K. Bajo

Graduate Theses, Dissertations, and Problem Reports (ETD)

The tradition of research in the experimental analysis of behavior generally emphasizes the analysis of overt, discrete responses such as lever presses or key pecks. Reflecting this emphasis, definitions of behavior involve the observable action or movement of an organism through space. Although continuous responses involving little to no movement, such as “holding still” or “immobility”, fall outside these definitions, immobility is a form of continuous, operant responding that can be learned and experimentally controlled. Three experiments were conducted to investigate parameters surrounding immobility as an operant. In Experiment 1, immobility in the form of platform-standing bouts was shaped and …


An Appalachian Perspective On Suicide: A Focus On West Virginia’S Unique Context, Erin Delaney Caswell Jan 2024

An Appalachian Perspective On Suicide: A Focus On West Virginia’S Unique Context, Erin Delaney Caswell

Graduate Theses, Dissertations, and Problem Reports (ETD)

INTRODUCTION: The Appalachian region, spanning 13 states from New York to northern Mississippi, experiences the suicide rates in the United States (U.S.), underscoring a public health crisis exacerbated by persistent socioeconomic challenges. West Virginia (WV), the only state entirely within Appalachia, serves as a focal point for understanding the broader suicide crisis in the region, as WV has the highest suicide rates in the region. Moreover, the state has several unique socioeconomic factors, like increased poverty, lower educational attainment, limited access to healthcare, and a high prevalence of chronic pain and substance that may contribute to elevated rates of suicide. …


Policy Dynamics In Young Democracies: Attention, Electoral Change, And Responsiveness In Ghana And South Africa, Christiana Bugri Jan 2024

Policy Dynamics In Young Democracies: Attention, Electoral Change, And Responsiveness In Ghana And South Africa, Christiana Bugri

Graduate Theses, Dissertations, and Problem Reports (ETD)

My dissertation is a collection of three essays that assess the nature of government attention in young democracies. Theories of the policy process focus on policy dynamics in Western democracies with little application to non-Western democracies. This dissertation bridges this gap by studying policy dynamics in the neopatrimonial democracies of Ghana and South Africa. The dissertation sheds light on how the unique features of young democracies (centralization, clientelism, and powerful executives) shape government attention, responsiveness to public opinion, and the importance of elections in policy change. The first essay examines the dynamics of government attention and how the neopatrimonial nature …


Laser Deposition Additive Manufacturing Of Multi-Material And Metal-Ceramic Composite Structures, Manikanta Grandhi Jan 2024

Laser Deposition Additive Manufacturing Of Multi-Material And Metal-Ceramic Composite Structures, Manikanta Grandhi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increasing performance requirements of modern industrial systems, coupled with the imperative for decarbonization, necessitate a fundamental rethinking of metallic component design and manufacturing. Traditional materials, with their inherent limitations in property optimization, susceptibility to degradation, and weight constraints, are proving insufficient. Multi-material joining offers a potential solution, enabling designers to strategically integrate diverse materials with specific, tailored properties into single component. Functionally graded materials (FGMs) and oxide dispersion strengthened (ODS) materials are prime examples of this approach, delivering substantial improvements in wear resistance, thermal regulation, high-temperature resilience, and overall weight efficiency. However, conventional manufacturing approaches further exacerbate the limitations …


Triggered Online System Re-Identification Applied To Model Predictive Control Using Gaussian Processes, Daniel Augusto Kestering Jan 2024

Triggered Online System Re-Identification Applied To Model Predictive Control Using Gaussian Processes, Daniel Augusto Kestering

Graduate Theses, Dissertations, and Problem Reports (ETD)

Safety, product quality, enhanced performance, and increased profit all depend on the control of chemical and energy processes. However, operational issues can lead to control challenges, especially when processes are subject to disturbances during their operation. Process control methods work best when processes operate close to their designed operat- ing conditions, but lack of performance or other issues may occur when the process is far from such conditions. To overcome these challenges, in this dissertation, online model re- identification is proposed for Model Predictive Control (MPC). This involves reassessing the predictive model of an advanced controller, namely MPC, when re-identification …


Piano Wisdom From Two Great Masters: Heinrich Neuhaus And Walter Gieseking, Xiaohan Hu Jan 2024

Piano Wisdom From Two Great Masters: Heinrich Neuhaus And Walter Gieseking, Xiaohan Hu

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the pedagogical insights and piano techniques of Heinrich Neuhaus (1888-1964) and Walter Gieseking (1895-1956), two iconic figures in 20th-century piano performance and education. Through a detailed analysis of their writings and teaching methods, the research highlights their shared focus on the foundational principles of piano technique, as well as their unique contributions to interpretation and musical expression.

Neuhaus’s The Art of Piano Playing provides an in-depth discussion on the importance of artistic imagery, posture, sound production, and emotional depth in performance. Gieseking, along with his former teacher Karl Leimer, emphasizes ear training, mental visualization, and technical precision …


Celluloid Shakespeare: An Exploration Of The Relationship Between Film And Theatre Through Edgar In Shakespeare’S King Lear, Liam Michael Holton Jan 2024

Celluloid Shakespeare: An Exploration Of The Relationship Between Film And Theatre Through Edgar In Shakespeare’S King Lear, Liam Michael Holton

Graduate Theses, Dissertations, and Problem Reports (ETD)

This document explores the actor‘s process and performance of Edgar in the 2021 WVU/WVPB production of William Shakespeare‘s King Lear. This production was directed by Professor Jerry McGonigle and was filmed during the height of the Covid-19 pandemic in partnership with West Virginia Public Broadcasting. This experimental project would go on to receive national distribution by the National Educational Television Association (NETA) and was also in consideration for a NETA award, in addition to receiving an Ohio Valley regional Emmy Award nomination as a finalist in the category of Arts/Entertainment – Short Form or Long Form Content. The following text …


Novel Membrane Materials For Nutrient Recovery From Nutrient-Rich Resources, Km Prottoy Shariar Piash Jan 2024

Novel Membrane Materials For Nutrient Recovery From Nutrient-Rich Resources, Km Prottoy Shariar Piash

Graduate Theses, Dissertations, and Problem Reports (ETD)

Global demand for fertilizer production is expanding substantially to meet the food demand of an increasing world population. Anaerobic digestate (AD) of various centralized wastewater facilities contains substantial amounts of ammonium (NH4+) (300-800 mg/L), potassium (K+) (13-120 mg/L), and phosphorus (P) (30-100 mg/L)- based nutrients. In addition to reducing energy costs and CO2 emissions compared to conventional fertilizing raw material manufacturing, recovering nutrients from these waste streams could help mitigate problems such as eutrophication, which otherwise incurs billions of dollars losses to US economy annually. Apart from nutrients, wastewater streams also contain organic pollutants …


From Measurement To Performance: Psychometric Validity And Psychological Predictors Of Reserve Officer Training Corps Cadets’ Performance On The Army Combat Fitness Test, Ari Joseph Sapinsley Jan 2024

From Measurement To Performance: Psychometric Validity And Psychological Predictors Of Reserve Officer Training Corps Cadets’ Performance On The Army Combat Fitness Test, Ari Joseph Sapinsley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding the psychological and physical readiness of future military leaders is crucial for improving recruitment and retention. The U.S. Army faces increasing obesity rates and declining physical fitness among recruits, reducing the pool of eligible candidates and raising costs. The Reserve Officer Training Corps (ROTC), which commissions 59% of officers, has higher attrition rates than other sources, underscoring the need to identify psychological predictors of performance. This dissertation examines the psychometric properties of psychological instruments used to assess ROTC cadets and their relationship with Army Combat Fitness Test (ACFT) performance. Two research questions were explored: (1) What are the psychometric …


Experimental Verification And Time-Resolved Bispectral Analysis Of Nonlinear Coupling In The Toroidicity-Induced Alfv´En Eigenmode Spectrum, Gregory Allen Riggs Jan 2024

Experimental Verification And Time-Resolved Bispectral Analysis Of Nonlinear Coupling In The Toroidicity-Induced Alfv´En Eigenmode Spectrum, Gregory Allen Riggs

Graduate Theses, Dissertations, and Problem Reports (ETD)

In magnetically-confined fusion devices, the toroidicity-induced Alfv´en eigenmode (TAE) is a well-studied, weakly stable solution of the linearized ideal magnetohydrodynamic (MHD) equations. Due to intrinsic coupling of poloidal harmonics of the shear Alfv´en wave (SAW) in toroidal geometry, the rotational transform of magnetic field lines modulates the effective index of refraction, ensuring gaps in the so-called “Alfv´en continuum.” Experimental verification of theoretical predictions for various parameters of interest (i.e., frequency, mode structure, instability threshold, etc.) is established in the literature.

We present the first systematic study of TAE-TAE phase coherence in an experimental device, using the DIII-D tokamak. Crucially, nonlinear …


Relationships Among The Concepts Of Organizational Theory And Nurse Burnout Before And After Covid-19, Bridget M. Webb Jan 2024

Relationships Among The Concepts Of Organizational Theory And Nurse Burnout Before And After Covid-19, Bridget M. Webb

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Nurse burnout is a global health priority that has been compounded by Coronavirus 2019 (COVID-19). Organizational theory states that nurse burnout is directly impacted by operant mechanisms (nurse characteristics, nurse specialization) and hospital-wide models. The purpose of this study is to determine the relationship between hospital wide models (evidence-based care, team-based care, discharge planning, care coordination), operant mechanisms (nurse characteristics, nurse specialization), and outcomes (nurse burnout) before and after COVID-19.

Research Question: The specific aim of this study is to determine the relationship between hospital wide models (evidence-based care, team-based care, discharge planning, care coordination) and operant mechanisms (nurse …


The Sociology Of Bail Reform: Crime, Social Interaction, And Offender Experiences In Rurality., Scott Kevin Turner Jan 2024

The Sociology Of Bail Reform: Crime, Social Interaction, And Offender Experiences In Rurality., Scott Kevin Turner

Graduate Theses, Dissertations, and Problem Reports (ETD)

The study sought to explore the impact of the New York State “Bail Reform Act of 2019,” in rurality. It examined some of the legislative goals of the law, the claim that it caused crime, and offender experiences in rurality. Secondary data was used to map the rural crime landscape and primary data was collected from offenders during face to face interviews. The study was framed using deterrence and opportunity approaches and situated within the broader field environments; legislative, courtroom, and community. The research failed to find support for the claim that bail reform caused crime. Instead, it revealed that …


The Search, The Localization, And The Characterization: Fast Radio Transients, Reshma Anna Thomas Jan 2024

The Search, The Localization, And The Characterization: Fast Radio Transients, Reshma Anna Thomas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fast radio transients are energetic bursts in centimeter or meter wave-lengths, lasting only milliseconds, and originating from both Galactic and extra-Galactic sources. In our Galaxy, these transients primarily originate from pulsars, which are rotating neutron stars. The more energetic extra-galactic transients, known as fast radio bursts (FRBs), have unknown origins. This thesis explores various techniques, including single dish and interferometric observations, to detect and accurately localize fast radio transients. It also investigates how the propagation effects of radio waves can reveal characteristics of the local environment and potential FRB sources. Furthermore, it demonstrates how FRBs can be used to study …


A Balancing Act: Microrna Mediated Insect-Bacterial Homeostasis And The Tsetse Fly, Mason Hubbard Lee Jan 2024

A Balancing Act: Microrna Mediated Insect-Bacterial Homeostasis And The Tsetse Fly, Mason Hubbard Lee

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microbial symbioses are ubiquitous across all kingdoms of life with broad and diverse impacts on the evolution of species. The sum of all microbes living in, on, or otherwise in close association with a host form the microbiota. In some cases, the development of a stable microbial association seems to have been necessary for the specialization of diet, as can be observed in numerous insect species, especially wood-eating, sap-feeding, and blood-feeding organisms. For the medically and economically tsetse fly (family Glossinidae), the mutualistic bacteria Wigglesworthia glossinidia is required for proper reproduction and supplementation of nutrients that the fly does not …


Effects Of Probabilistic Win-Paired-Cue Delivery On Loss Trials On Risky Choice In Rats, Connor M. Lambert Jan 2024

Effects Of Probabilistic Win-Paired-Cue Delivery On Loss Trials On Risky Choice In Rats, Connor M. Lambert

Graduate Theses, Dissertations, and Problem Reports (ETD)

Problem gambling, or Gambling Disorder, is a behavioral disorder that affects 2.5% of the U.S. population and can result in detriments to physical, mental, and financial well-being. Electronic gambling machines (e.g., slot machines, video poker, pachinko) may be more addictive than other forms of gambling (e.g., table games, sports betting). Electronic gambling machines present a series of audiovisual stimuli concurrently with winning and some losing outcomes. Previous research in human and non-human animals has found increased levels of risky choice when audiovisual stimuli are presented with wins compared to their absence. The present study was arranged to evaluate how a …


A Grounded Theory Investigation Of Basic Psychological Needs Theory As A Framework For Effective Mental Health Referrals In Collegiate Sport, Luna Ugrenović Jan 2024

A Grounded Theory Investigation Of Basic Psychological Needs Theory As A Framework For Effective Mental Health Referrals In Collegiate Sport, Luna Ugrenović

Graduate Theses, Dissertations, and Problem Reports (ETD)

Using a grounded theory approach, this study explored collegiate athletes’ mental health referral experiences and identified mechanisms explaining those experiences based upon perceptions of psychological need fulfillment and thwarting according to Basic Psychological Needs Theory (BPNT). Interviews were conducted with a purposive, maximum variation sample of 14 current and former collegiate athletes who were referred to mental health services by support personnel or other athletes. Analyses yielded three overarching theoretical categories/properties: pre-referral factors, proactive and reactive referral conversations, and referral outcomes. Referral is often understood as an isolated conversation in which athletes are provided mental health resources in response to …


A Self-Supervised Knowledge Distillation Approach To Anomaly Detection In X-Ray Imagery, Kaden Quinn Mceldowney Jan 2024

A Self-Supervised Knowledge Distillation Approach To Anomaly Detection In X-Ray Imagery, Kaden Quinn Mceldowney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Many cargo containers enter the United States every day by truck, rail, and sea. As a result of the large number of cargo containers entering the United States, not all of them can be thoroughly inspected. Most of these containers contain properly documented and legal cargo, but some people take advantage of this situation by hiding illicit items in the cargo containers such as drugs. To more efficiently and thoroughly inspect cargo containers, Customs and Border Protection (CBP) uses X-ray imaging machines to obtain images that reveal the interior of cargo containers. These X-ray images must be inspected to ensure …


Machine Learning Based Intrusion Detection Framework For Can Bus Vulnerabilities In Modern Vehicles, Obinna C. Agbo Jan 2024

Machine Learning Based Intrusion Detection Framework For Can Bus Vulnerabilities In Modern Vehicles, Obinna C. Agbo

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Controller Area Network (CAN) bus is a crucial communication backbone in modern vehicles, connecting various Electronic Control Units (ECUs). However, inherent design weaknesses such as the lack of encryption and authentication make CAN networks vulnerable to cyber-attacks, including spoofing, Denial of Service (DoS), and fuzzing attacks. This thesis thoroughly evaluates these vulnerabilities and the limitations of existing security frameworks like Message Authentication Codes (MACs) and encryption, advocating for the adoption of Intrusion Detection Systems (IDS) as a more practical solution for CAN bus security. The proposed IDS leverages advanced machine learning techniques to accurately detect intrusions, even under complex …


It's Written All Over Your Face: A Cultural And Gender History Of The Face In The Middle Ages, 1170-1500, Lacey N. Bonar Hull Jan 2024

It's Written All Over Your Face: A Cultural And Gender History Of The Face In The Middle Ages, 1170-1500, Lacey N. Bonar Hull

Graduate Theses, Dissertations, and Problem Reports (ETD)

At a time of vast social and cultural shifts, people living in western Europe from the late twelfth to the late fifteenth centuries developed and employed methods to “read” the faces of others. This practice promoted the interpretation of inner qualities from external appearances, often used to communicate adherence to or deviation from boundaries of gendered behaviors. My project explores medieval understandings concerning this particular feature of the human body, analyzing discourses concerning the face as a site of symbolism for inner character. While scholars have studied understandings of the self and the “Other” during this period, the role of …


Improving Awareness And Identifying Risks For Emergence Delirium In Military Veterans, Hannah E. Pino Jan 2024

Improving Awareness And Identifying Risks For Emergence Delirium In Military Veterans, Hannah E. Pino

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Emergence delirium (ED) is an acute state of confusion during the recovery phase from anesthesia that may be life-threatening, especially in the veteran population. Military veteran status may be explored by the Have You Ever Served questionnaire that was developed by the American Academy of Nursing to identify veterans upon admission to the hospital and thus be able to better care for them during their stay. This campaign has been in effect at the hospital site of this project for nearly 10 years. The questionnaire identifies military history risk factors such as combat history or a diagnosis of post-traumatic …


Utilizing Arcgis Storymap To Raise Awareness: Double Dispossession Of The Gullah Geechee On Sapelo Island, Noah A. Moulton Jan 2024

Utilizing Arcgis Storymap To Raise Awareness: Double Dispossession Of The Gullah Geechee On Sapelo Island, Noah A. Moulton

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Gullah Geechee people, descendants of enslaved Africans brought to the Sea Islands of the Atlantic Coast, represent a resilient community whose heritage and practices have endured despite centuries of systemic oppression. This research examines the intersection of history, land dispossession, and environmental threats to the Gullah Geechee community, particularly on Sapelo Island. By exploring the enduring agricultural knowledge, language, and practices, this work underscores the significance of the Gullah Geechee's connection to their ancestral lands, which have been essential for the preservation of their identity. The dual forces of gentrification and climate change present pressing challenges, manifesting as both …


A Multi-Omics Multi-Environment Prediction In Pulse Crop, Rica Saludares Jan 2024

A Multi-Omics Multi-Environment Prediction In Pulse Crop, Rica Saludares

Plant Sciences

Understanding the genetic bases underlying seed yield and protein, and eventually recombining them in desired genetic backgrounds, continues to be a challenge to pulse crop breeders. Phenotypic selection for seed yield and protein in preliminary yield trials is hindered by the need to phenotype a large number of early-generation lines (>10,000) with limited seeds, resulting to trials with few replications and limited environments. In this study, we evaluated and applied a multi-trait multi-environment (MTME) and a multi-omics prediction framework to address phenotyping bottleneck and the complexities underlying negatively correlated traits, and maximize connectivity among genotypes for predicting performance of …


A Mini Chalk Talk Workshop For Fourth-Year Medical Students: Facilitating The Transition From Student To Resident Educator, Trevor Jamison, Zaven Sargsyan, Uma Ayyala, Stephanie Sherman, Holland Kaplan Jan 2024

A Mini Chalk Talk Workshop For Fourth-Year Medical Students: Facilitating The Transition From Student To Resident Educator, Trevor Jamison, Zaven Sargsyan, Uma Ayyala, Stephanie Sherman, Holland Kaplan

Faculty, Staff and Students Publications

INTRODUCTION: There is increasing recognition that incoming interns benefit from formal training in teaching skills during UME. Many medical schools have capstone courses well suited for teacher-training content. Mini chalk talks (MCTs) are a common clinical teaching modality requiring a variety of teaching skills. We developed a session for our institution's capstone course in which students prepared and delivered MCTs.

METHODS: The voluntary flipped classroom session was offered virtually in 2021 and in person in 2022. Before the session, students reviewed materials on creating effective MCTs and developed and practiced their own MCT. During the 90-minute session, students presented their …


High Prevalence Of A-Β+ Ketosis-Prone Diabetes In Children With Type 2 Diabetes And Diabetic Ketoacidosis At Diagnosis: Evidence From The Rare And Atypical Diabetes Network (Radiant), Elizabeth Kubota-Mishra, Xiaofan Huang, Charles G Minard, Marcela Astudillo, Ahmad Refaey, Graciela Montes, Stephanie Sisley, Nalini Ram, William E Winter, Rochelle N Naylor, Ashok Balasubramanyam, Maria J Redondo, Mustafa Tosur, Radiant Study Group Jan 2024

High Prevalence Of A-Β+ Ketosis-Prone Diabetes In Children With Type 2 Diabetes And Diabetic Ketoacidosis At Diagnosis: Evidence From The Rare And Atypical Diabetes Network (Radiant), Elizabeth Kubota-Mishra, Xiaofan Huang, Charles G Minard, Marcela Astudillo, Ahmad Refaey, Graciela Montes, Stephanie Sisley, Nalini Ram, William E Winter, Rochelle N Naylor, Ashok Balasubramanyam, Maria J Redondo, Mustafa Tosur, Radiant Study Group

Faculty, Staff and Students Publications

BACKGROUND:A−β+ ketosis-prone diabetes (KPD) in adults is characterized by presentation with diabetic ketoacidosis (DKA), negative islet autoantibodies, and preserved β-cell function in persons with a phenotype of obesity-associated type 2 diabetes (T2D). The prevalence of KPD has not been evaluated in children. We investigated children with DKA at “T2D” onset and determined the prevalence and characteristics of pediatric A−β+ KPD within this cohort.

METHODS: We reviewed the records of 716 children with T2D at a large academic hospital and compared clinical characteristics of those with and without DKA at onset. In the …


Inhibition Of Src-3 As A Potential Therapeutic Strategy For Aggressive Mantle Cell Lymphoma, Imani Bijou, Yang Liu, Dong Lu, Jianwei Chen, Shelby Sloan, Lapo Alinari, David M Lonard, Bert W O'Malley, Michael Wang, Jin Wang Jan 2024

Inhibition Of Src-3 As A Potential Therapeutic Strategy For Aggressive Mantle Cell Lymphoma, Imani Bijou, Yang Liu, Dong Lu, Jianwei Chen, Shelby Sloan, Lapo Alinari, David M Lonard, Bert W O'Malley, Michael Wang, Jin Wang

Faculty, Staff and Students Publications

Mantle cell lymphoma (MCL) has a poor prognosis and high relapse rates despite current therapies, necessitating novel treatment regimens. Inhibition of SRC-3 show effectiveness in vivo and in vitro in other B cell lymphomas. Additionally, previous studies have shown that SRC-3 is highly expressed in the lymph nodes of B cell non-Hodgkin's lymphoma patients, suggesting SRC-3 may play a role in the progression of B cell lymphoma. This study aimed to investigate novel SRC-3 inhibitors, SI-10 and SI-12, in mantle cell lymphoma. The cytotoxic effects of SI-10 and SI-12 were evaluated in vitro and demonstrated dose-dependent cytotoxicity in a panel …


Effects Of Synonymous And Nonsynonymous Cyp51 Mutations On Dmi Resistance In Cercospora Beticola, Isaac Courneya Jan 2024

Effects Of Synonymous And Nonsynonymous Cyp51 Mutations On Dmi Resistance In Cercospora Beticola, Isaac Courneya

Plant Pathology

Cercospora beticola is the most devastating foliar pathogen of sugar beet. This pathogen is primarily managed by the application of fungicides, including demethylation inhibitors (DMIs). Given the broad use of DMIs in managing Cercospora leaf spot, resistance has developed. Recently, five haplotypes of CbCyp51 have been correlated with DMI resistance. To improve our understanding of these haplotypes, this study has evaluated CbCyp51 expression across haplotypes with and without DMI exposure using RT-qPCR. Significant differences were found between haplotypes in control and difenoconazole groups, but the broader implications were unclear. This study also produced mutant C. beticola strains with replaced CbCyp51 …