Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2024

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 8461 - 8490 of 11663

Full-Text Articles in Entire DC Network

Intake, Relative Palatability Indices And Blood Parameters Of Vetch Varieties As A Component Of Goat Diet, N. H. Msiza, K. E. Ravhuhali, H. K. Mokoboki, Sydney Mavengahama, G. M. Chelopo Feb 2024

Intake, Relative Palatability Indices And Blood Parameters Of Vetch Varieties As A Component Of Goat Diet, N. H. Msiza, K. E. Ravhuhali, H. K. Mokoboki, Sydney Mavengahama, G. M. Chelopo

IGC Proceedings (1977-2023)

Therefore, the objective of this study was to assess the feed intake, relative palatability indices and blood parameters of vetch varieties as a component of goat diet. The field and palatability study was carried out at the North West University, Molelwane Farm, North West province, South Africa. Ten weaner goats (16 ±2 kg) were used in this experiment. Four feeds (Vicia sativa – common & volga vetch ), Vicia villosa Roth (haymaker plus vetch) and buffalo hay grass were used in this experiment and each goat was exposed to these treatment diets. A cafeteria feeding method was used, allowing …


Stockpiling Tall Fescue In The Mid-Latitude Region Of The Eastern United States, H. D. Naumann Feb 2024

Stockpiling Tall Fescue In The Mid-Latitude Region Of The Eastern United States, H. D. Naumann

IGC Proceedings (1977-2023)

Stockpiling grass is a method of growing forage for deferred grazing during winter. Tall fescue is the best adapted cool-season perennial grass available in the mid-latitude of the eastern United States (US) for stockpiling (accumulating growth of) forage for deferred grazing in the fall and winter. Thus it can provide much of the fall and winter feed for livestock. Grazing stockpiled tall fescue reduces winter feeding cost and better distributes nutrients compared to traditional hay feeding methods. This presentation focuses on how to stockpile tall fescue, how to graze stockpiled tall fescue, and benefits of stockpiled tall fescue compared to …


Dry Matter Intake, Milk Performance And Production Efficiency From Spring Calving Dairy Cows Offered Grass-Only, Grass-White Clover And Total Mixed Ration Diets, E. Fitzpatrick, Luc Delaby, Trevor J. Gilliland, D. Hennessy Feb 2024

Dry Matter Intake, Milk Performance And Production Efficiency From Spring Calving Dairy Cows Offered Grass-Only, Grass-White Clover And Total Mixed Ration Diets, E. Fitzpatrick, Luc Delaby, Trevor J. Gilliland, D. Hennessy

IGC Proceedings (1977-2023)

In pasture-based dairy production systems, dry matter intake (DMI) is one of the main factors curtailing milk production and production efficiency. The inclusion of white clover (Trifolium repens L.) in swards of perennial ryegrass (PRG; Lolium perenne L.) can increase DMI from increased sward nutritive value over a grass-only sward. Feeding a fully balanced TMR diet can enhance milk production as a result of greater DMI and through greater control of feed quality. Therefore, the objective of this study was to determine the relationship between DMI, milk production, and energy efficiencies for dairy cows consuming different diets. A farm …


Forage Plant Secondary Metabolites At The Intersection Of Animal Health, Productivity, And Sustainability, Michael D. Flythe Feb 2024

Forage Plant Secondary Metabolites At The Intersection Of Animal Health, Productivity, And Sustainability, Michael D. Flythe

IGC Proceedings (1977-2023)

The nutritive value of forages and other feeds have long been studied. However, the roles of secondary metabolites produced by forage-plants and their endophytes are an emerging field. Historically, the term secondary metabolite was used for compounds that were less abundant in plant tissue than the primary metabolites, such as fiber, sugars, and protein. It has become clear that secondary metabolites play important roles in the ecology of forage plants, and that both the detrimental and beneficial impacts of secondary metabolites to forage-animals should not be underestimated. This thematic session will consider fescue toxicosis, a detrimental outcome of ergot alkaloids …


Grazing Behavior Of The Endemic Lagune Cattle In The Sub-Humid Savannahs Of Benin, E. Sonon, G. G. Alowanou, B. I. Koura, O. J. Makinde, A. B. Gbangboche Feb 2024

Grazing Behavior Of The Endemic Lagune Cattle In The Sub-Humid Savannahs Of Benin, E. Sonon, G. G. Alowanou, B. I. Koura, O. J. Makinde, A. B. Gbangboche

IGC Proceedings (1977-2023)

The indigenous Lagune, a breed tolerant to trypanosomiasis, is an excellent candidate to meet the ongoing environmental changes sustainably. This cattle breed could be kept like small ruminants, tethered in grasslands, or free grazing. A study was conducted to assess the grazing behavior of Lagune cattle under the two grazing systems to identify the best systems for sustainable production and conservation of the breed. For this study, four Lagune cattle farms, 02 under free-roaming and 02 others in the tethered system, were selected in the original belt of the Lagune cattle, the agro-ecological (AEZ) zones of Valley and Pobe. The …


Stockpiling Perennial Warm-Season Grasses: Bermudagrass Example, J. A. Jennings, K. J. Simon Feb 2024

Stockpiling Perennial Warm-Season Grasses: Bermudagrass Example, J. A. Jennings, K. J. Simon

IGC Proceedings (1977-2023)

Winter feeding is the largest expense of maintaining a beef herd in terms of money and time. Stockpiled bermudagrass is an effective practice for reducing winter feeding expenses and extending the grazing season. Stockpiling forage is the practice of accumulating forage growth intended for grazing in a later season. In Arkansas, bermudagrass is stockpiled from early August to late October and is grazed from late October through mid-December. Rainfall during late summer can be erratic with high risk of drought stress, but an early start date maximizes the opportunity for acceptable stockpiled forage yield. Therefore, stockpiling bermudagrass should begin by …


Tall Fescue And Orchardgrass Productivity And Persistence Under Grazing Systems In Tennessee, K. Johnson, R. N. Oakes, G. Bates Feb 2024

Tall Fescue And Orchardgrass Productivity And Persistence Under Grazing Systems In Tennessee, K. Johnson, R. N. Oakes, G. Bates

IGC Proceedings (1977-2023)

The primary forage species used by cow-calf producers in grazing systems in Tennessee is tall-fescue. Tall fescue is considered an excellent cool-season perennial forage crop due to its high quality, production, and extended growing season. However, most of these tall fescue grazing systems are composed of tall fescue cv. Kentucky 31, which is known for containing a fungus endophyte that can be toxic to animals. Alternatively, orchardgrass is also a vastly used and important perennial cool-season forage in the United States. It can be used as a pasture, hay, and is a high-quality forage that is desirable for most livestock …


Effect Of Apple Pomace Based Silage On Lactation Performance Of Crossbred Cows, Ngahanyui Kengoo, Rohit Bishist Feb 2024

Effect Of Apple Pomace Based Silage On Lactation Performance Of Crossbred Cows, Ngahanyui Kengoo, Rohit Bishist

IGC Proceedings (1977-2023)

The present study was conducted to evaluate the effect of inclusion of apple pomace based silage on milk performance of crossbred cows at Dr Y S Parmar University of Horticulture and Forestry, Nauni, Solan, Himachal Pradesh, India. In a feeding trial of 90 days duration, 12 crossbred cows were selected on the basis of their milk yield and were divided into two groups of six animals each. Animals in the control group were fed with the standard feeding practices of the farm i.e., concentrate @ 4kg d-1, wheat straw @ 5 kg d-1 and Grewia optiva tree fodder @ 10 …


Leucaena Leucocephala As An Alternative Protein Supplement To Fishmeal For Small Holder Indigenous Lactating Cows In Bangladesh, M. A. S. Khan Feb 2024

Leucaena Leucocephala As An Alternative Protein Supplement To Fishmeal For Small Holder Indigenous Lactating Cows In Bangladesh, M. A. S. Khan

IGC Proceedings (1977-2023)

In Bangladesh, locally produced fishmeal is being used as a protein source for lactating cows but sometimes it is scarce and expensive. There is a need for an alternative protein source such as a Leucaena species which can be grown by the roadside, embankment or in a small area close to home. An experiment was carried out to assess the effect on the performance of partially replacing fishmeal with fresh foliage from Leucaena leucocephalain the diet of lactating cows. Three diets containing (kg/day) urea-treated rice straw (11.0) with either fishmeal (0.25), fishmeal (0.15) and Leucaena (0.5), and fishmeal (0.075) and …


Corn Silage Yield And Quality, And Soil Health Metrics After Fall Cover Crop Grazing, J. D. King, K. A. Cassida, R. Erhardt, E. Burns, S. Snapp, M. Singh, C. Difonzo, A. Garmyn, S. Gruss, C. Macaluso Feb 2024

Corn Silage Yield And Quality, And Soil Health Metrics After Fall Cover Crop Grazing, J. D. King, K. A. Cassida, R. Erhardt, E. Burns, S. Snapp, M. Singh, C. Difonzo, A. Garmyn, S. Gruss, C. Macaluso

IGC Proceedings (1977-2023)

Integrated crop-livestock systems can potentially produce more product per unit of land with minimal impacts on soil health and cash crop quality. In the Upper Midwest there is an opportunity to graze fall cover crops (CC) after winter wheat in a corn-wheat rotation. In East Lansing, Michigan, two CC treatments: 1) a pure brassica mixture (PURE), and 2) a complex mixture containing legumes, warm and cool season grasses, and brassicas (MIX) were planted after wheat, and grazed by lambs in the fall seasons of 2019 to 2021. The following year, soil health, corn yield and quality were measured from plots …


Forages For Horses Revamped, C. Gelley, E. Lyon, H. Zynda, S. Mastellar, E. Share, B. Hendershot, D. Kreager, G. Wilson, R. Purdin, J. Hampton, J. Morris, T. Wiseman, L. Beers, M. Sulc Feb 2024

Forages For Horses Revamped, C. Gelley, E. Lyon, H. Zynda, S. Mastellar, E. Share, B. Hendershot, D. Kreager, G. Wilson, R. Purdin, J. Hampton, J. Morris, T. Wiseman, L. Beers, M. Sulc

IGC Proceedings (1977-2023)

The Forages for Horses program began in Ohio in1998 as a collaboration between the Ohio Forages & Grasslands Council and Ohio State University Extension. Over time, additional collaborations with the Natural Resources Conservation Service, Ohio Department of Agriculture and local Soil and Water Conservation Districts expanded the program. At its inception, one to three educators would partner to provide eight hours of in-person lectures followed by a pasture walk to better the management practices of equine enthusiasts. From 2021 through 2022, the curriculum was adapted for a hybrid classroom and included three 90-minute live webinars featuring nine different presentations followed …


Bale Grazing: Feeding Hay On Pasture Using Rotational Grazing Techniques, Greg Halich Feb 2024

Bale Grazing: Feeding Hay On Pasture Using Rotational Grazing Techniques, Greg Halich

IGC Proceedings (1977-2023)

Bale grazing is a novel winter-feeding method where bales are set out on pasture, typically in checkerboard fashion, and fed in a planned, controlled manner, much like rotational grazing. So far, the concept has not been widely adopted in the eastern US, but offers an improved alternative compared to conventional winter-feeding systems for beef cattle, which all too often results in wasted nutrients, polluted waterways, degraded soils, and unhealthy conditions for cattle. With good management, bale grazing can solve all of these problems, and also requires less labor and machinery use than conventional hay feeding. However, climatic conditions in the …


More Than Fiber: Forage Carbohydrates Affecting Animal Performance, M. B. Hall Feb 2024

More Than Fiber: Forage Carbohydrates Affecting Animal Performance, M. B. Hall

IGC Proceedings (1977-2023)

Forages are well known as an important source of fiber in livestock diets. However, their carbohydrate contribution is more than fiber. Forage grasses and legumes supply sugars, fructans, and other water-soluble carbohydrates as well as soluble fiber that behave very differently than starch in the rumen. With a focus on ruminants, we will explore the forage supply, and ruminal and animal impacts.


Extending The Grazing Season Through The Use Of Cover Crops, D. D. Harmon Feb 2024

Extending The Grazing Season Through The Use Of Cover Crops, D. D. Harmon

IGC Proceedings (1977-2023)

The use of cover crops in integrated crop-livestock systems is not a novel approach but has increased in popularity over the last few years due to the renewed interest in soil conservation, nutrient cycling, and water conservation. Moreover, cool-season annual forages have the ability to extend the grazing season, reduce the need for stored or bought supplemental feedstuffs, and as a result, lower winter-feeding costs. Small grain cover crops, legumes, forbes, and annual ryegrass (Lolium multiflorum Lam.) vary in their growth distribution and can be planted alone in monocultures or planted in mixtures to take advantage of the individual …


In Vitro Methane Production From Heifers Offered Four Bermudagrass Cultivars, A. R. Hines, W. G. Bergen, M. K. Mullenix, S. L. Dillard, T. R. Callaway, W. B. Smith Feb 2024

In Vitro Methane Production From Heifers Offered Four Bermudagrass Cultivars, A. R. Hines, W. G. Bergen, M. K. Mullenix, S. L. Dillard, T. R. Callaway, W. B. Smith

IGC Proceedings (1977-2023)

Though bermudagrass (Cynodon dactylon [L.] Pers.) is one of the predominant warm-season perennial forage supporting the southeastern United States livestock production systems, little is known about its influence on parameters of ruminal metabolism, including carbon loss as methane. With the multitude of cultivars of this grass that have been developed and released, one may question whether the physiological cultivar differences will manifest varying results in digestive efficiency and subsequent methane emissions. Thus, the objective of this study was to evaluate in vitro methane (CH4) production as influenced by four bermudagrass cultivars. Ruminally-fistulated heifers (n = 4) were assigned randomly …


Adoption Of Plantain Within New Zealand Farming Systems, Michael B. Dodd, J. B. Pinxterhuis, P. Hedley, L. Keenan, A. Duker, A. Moorhead Feb 2024

Adoption Of Plantain Within New Zealand Farming Systems, Michael B. Dodd, J. B. Pinxterhuis, P. Hedley, L. Keenan, A. Duker, A. Moorhead

IGC Proceedings (1977-2023)

In New Zealand, plantain has been incorporated into the pasture forage base in three ways: as a short-term pure crop; as a major component in “herb mixes” that include clovers and chicory; and as a minor component in perennial grass-based swards. All types are typically grazed in-situ. Given the incentive to optimise the plantain proportion in livestock diet to mitigate nitrogen losses and the observed lack of persistence in grass-dominant pasture over time, there is a need to use various pasture types strategically across a farm system to ensure a long-term sustainable contribution of plantain to feed intake. The inclusion …


A Multicriteria Assessment Of Forage Or Concentrate-Based Finishing Diets For Temperate Pasture-Based Suckler Beef Production Systems, P. R. Doyle, Edward G. O’Riordan, Mark Mcgee, Paul Crosson, A. K. Kelly, A. P. Moloney Feb 2024

A Multicriteria Assessment Of Forage Or Concentrate-Based Finishing Diets For Temperate Pasture-Based Suckler Beef Production Systems, P. R. Doyle, Edward G. O’Riordan, Mark Mcgee, Paul Crosson, A. K. Kelly, A. P. Moloney

IGC Proceedings (1977-2023)

This study evaluated the effect of contrasting ‘finishing’ diets on animal performance, meat nutritional value, land use, food-feed competition, farm economics and greenhouse gas (GHG) emissions in temperate pasture-based suckler weanling-to-steer beef systems. Post-weaning, eight-month-old, spring-born, late-maturing breed steers (333 kg) were assigned to one of three systems: (1) Grass silage + 1.2 kg concentrate DM (148 days), followed by pasture (123 days) and finished on ad libitum concentrates (120 days) - slaughter age, 21 months (GRAIN); (2) as per (1) but pasture (196 days) and finished on grass silage ad libitum + 3.5 kg concentrate DM (124 days) - …


Nutrient Cycling And Crop Responses On Integrated Crop-Livestock Systems, José C. B. Dubeux Jr., E. R. S. Santos, J. E. Portuguez-Acuna, L. M. D. Queiroz Feb 2024

Nutrient Cycling And Crop Responses On Integrated Crop-Livestock Systems, José C. B. Dubeux Jr., E. R. S. Santos, J. E. Portuguez-Acuna, L. M. D. Queiroz

IGC Proceedings (1977-2023)

Integrated crop-livestock systems (ICLS) can bring numerous benefits to crops or livestock systems, such as increase soil C sequestration, farm profitability, and provisioning of ecosystem services. In a changing world, production systems need to become more resilient and sustainable. Specialized agriculture is characterized by a high level of inputs and outputs, and oftentimes specialize in a single crop to simplify management. However, such operational systems stray away from sustainable standards. Furthermore, specialized cropping systems may face problems such as persistence of pests and diseases, loss of biodiversity, stagnant yields, development of herbicide-resistant weeds, soil erosion and consequently loss of soil …


Forage Brassica Use In New Zealand And Australia Farming Systems, A. Dumbleton, H. G. Judson Feb 2024

Forage Brassica Use In New Zealand And Australia Farming Systems, A. Dumbleton, H. G. Judson

IGC Proceedings (1977-2023)

Forage brassica, genus Brassica, are annual feed crops grown on farming enterprises throughout New Zealand and Australia. These crops provide a source of high-yielding, high-quality feed, which is particularly useful to complement pasture production during periods when pasture growth is reduced. There are six forage brassica species and subspecies of agricultural importance including bulb turnip, swede, kale, forage rape, leafy turnip, and raphanobrassica. All of these, as well as interspecific crosses and individual cultivars, offer a range of characteristics to fit various environmental and livestock production challenges. Consumption of forage brassica crops in ruminant animals may reduce methane emissions …


Faculty Senate Executive Committee Agenda February 20, 2024, Utah State University Feb 2024

Faculty Senate Executive Committee Agenda February 20, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

  • Call to Order
  • Approval of Minutes - January 22, 2024
  • University Business
  • Faculty Senate Business
  • Information
  • Education Policies Committee - December 7, 2023 | January 4, 2024
  • New Limited English Proficiency (LEP) Policy
  • Reports
  • Faculty Diversity, Development, & Equity Annual Report
  • Parking and Transportation Committee Annual Report
  • Sustainability Council Annual Report
  • Old Business
  • Update on IRB Ad Hoc Committee
  • Update on Faculty Code 405
  • New Business

  • Faculty Code 407 Redline - Clean | 408 Redline - Clean
  • Adjourn: 5:00 pm


Relevance Of Individual Data When Assessing The Gastrointestinal Nematode Infection Level, Nutritional And Productive Variables In A Tropical Farm Context: The Median Isn’T The Message, Gabriel Andrés Ortíz-Domínguez, Pedro Geraldo González-Pech, Juan Felipe De Jesús Torres-Acosta, Javier Ventura-Cordero, Juan Villalba, Carlos Alfredo Sandoval-Castro Feb 2024

Relevance Of Individual Data When Assessing The Gastrointestinal Nematode Infection Level, Nutritional And Productive Variables In A Tropical Farm Context: The Median Isn’T The Message, Gabriel Andrés Ortíz-Domínguez, Pedro Geraldo González-Pech, Juan Felipe De Jesús Torres-Acosta, Javier Ventura-Cordero, Juan Villalba, Carlos Alfredo Sandoval-Castro

Wildland Resources Faculty Publications

We evaluated the relationship between individual and herd GIN infection level, nutrition, production performance and anemia parameters in a tropical farm context. Fifty-four female goats were monitored to assess their body condition score (BCS, nutritional status indicator), live weight (LW) and LW gain (LWG, both used as production level indicators), FAMACHA© and hematocrit (HT, both used as anemia indicators). Goats browsed for 4 h in a tropical forest and received balanced feed and chopped grass. The eggs per gram of feces (EPG) indicated the GIN burden, with fecal samples obtained at 7:00 (AM) and 15:00 h (PM.) from each goat …


Pluripotency Of A Founding Field: Rebranding Developmental Biology, Crystal D. Rogers, Chris Amemiya, Swathi Arur, Leslie Babonis, Michael Barresi, Madelaine Bartlett, Richard Behringer, Blair Benham-Pyle, Dominique Bergmann, Ben Blackman, C. Titus Brown, Bill Browne, Jasmin Camacho, Chiswili Y. Chabu, Ida Chow, Ondine Cleaver, Jonah Cool, Megan Y. Dennis, Alexandra J. Dickinson, Stefano Di Talia, Margaret Frank Feb 2024

Pluripotency Of A Founding Field: Rebranding Developmental Biology, Crystal D. Rogers, Chris Amemiya, Swathi Arur, Leslie Babonis, Michael Barresi, Madelaine Bartlett, Richard Behringer, Blair Benham-Pyle, Dominique Bergmann, Ben Blackman, C. Titus Brown, Bill Browne, Jasmin Camacho, Chiswili Y. Chabu, Ida Chow, Ondine Cleaver, Jonah Cool, Megan Y. Dennis, Alexandra J. Dickinson, Stefano Di Talia, Margaret Frank

Pacific Faculty Work

The field of developmental biology has declined in prominence in recent decades, with off-shoots from the field becoming more fashionable and highly funded. This has created inequity in discovery and opportunity, partly due to the perception that the field is antiquated or not cutting edge. A 'think tank' of scientists from multiple developmental biology-related disciplines came together to define specific challenges in the field that may have inhibited innovation, and to provide tangible solutions to some of the issues facing developmental biology. The community suggestions include a call to the community to help 'rebrand' the field, alongside proposals for additional …


Effects Of Metformin On Glucose Metabolism And Mitochondrial Function In Patients With Obstructive Sleep Apnea: A Pilot Randomized Trial, Elizabeth R.M. Zunica, Elizabeth C. Heintz, Wagner S. Dantas, R. Caitlin Hebert, Ma Kayla Tanksley, Robbie A. Beyl, Edward C. Mader, John P. Kirwan, Christopher L. Axelrod, Prachi Singh Feb 2024

Effects Of Metformin On Glucose Metabolism And Mitochondrial Function In Patients With Obstructive Sleep Apnea: A Pilot Randomized Trial, Elizabeth R.M. Zunica, Elizabeth C. Heintz, Wagner S. Dantas, R. Caitlin Hebert, Ma Kayla Tanksley, Robbie A. Beyl, Edward C. Mader, John P. Kirwan, Christopher L. Axelrod, Prachi Singh

School of Medicine Faculty Publications

Obstructive sleep apnea (OSA) is associated with increased risk for diabetes, and standard treatment with positive airway pressure (PAP) device shows inconsistent effects on glucose metabolism. Metformin is known to treat and prevent diabetes, but its effects on skeletal muscle mitochondrial function are not completely understood. Here, we evaluate the effects of metformin on glucose metabolism and skeletal muscle mitochondrial function in patients with OSA. Sixteen adults with obesity (50.9 ± 6.7 years, BMI: 36.5 ± 2.9 kg/m2) and moderate-to-severe OSA were provided with PAP treatment and randomized to 3 months of placebo (n = 8) or metformin (n = …


Veggie Meat Alternatives: A Virtue-Ethical View, Carlo Alvaro Feb 2024

Veggie Meat Alternatives: A Virtue-Ethical View, Carlo Alvaro

Publications and Research

This chapter discusses practical and ethical aspects concerning veggie meat alternatives. Upon consideration, it is argued that while the production, sale, and consumption of veggie meat alternatives seemingly contribute to a solution to environmental problems, we ought to consider veggie meat alternatives from a virtue-ethical perspective concerning human excellence and flourishing. Doing so reveals previously unexplored ethical reasons for not promoting the production, sale, and consumption of veggie meat alternatives. One reason in particular is that veggie meat alternatives stem from the lack of the virtue of temperance.


Children In The Workplace: An Exploration In Library Policy Making, Sharolyn Swenson, Marissa Anne Bischoff, Ryan Lee Feb 2024

Children In The Workplace: An Exploration In Library Policy Making, Sharolyn Swenson, Marissa Anne Bischoff, Ryan Lee

Faculty Publications

Children in the workplace are becoming a more common discussion in various work environments, including libraries. Since the university has no policy addressing this issue, a task force was charged to draft a recommended policy for the university library regarding bringing children to the workplace. The task force reviewed existing policies and conducted a survey and interviews with library employees. The resulting policy provided guidelines for employees and their supervisors without being overly prescriptive. This article provides a case study of how the task force used assessment methods and tools to create an appropriate and inclusive policy. While the specific …


Phase I Study Of Mtorc1/2 Inhibitor Sapanisertib (Cb-228/Tak-228) In Combination With Metformin In Patients With Mtor/Akt/Pi3k Pathway Alterations And Advanced Solid Malignancies, Vivek Subbiah, Niamh Coleman, Sarina A Piha-Paul, Apostolia M Tsimberidou, Filip Janku, Jordi Rodon, Shubham Pant, Ecaterina E Ileana Dumbrava, Siqing Fu, David S Hong, Shizhen Zhang, Ming Sun, Yunfang Jiang, Jason Roszik, Juhee Song, Ying Yuan, Funda Meric-Bernstam, Aung Naing Feb 2024

Phase I Study Of Mtorc1/2 Inhibitor Sapanisertib (Cb-228/Tak-228) In Combination With Metformin In Patients With Mtor/Akt/Pi3k Pathway Alterations And Advanced Solid Malignancies, Vivek Subbiah, Niamh Coleman, Sarina A Piha-Paul, Apostolia M Tsimberidou, Filip Janku, Jordi Rodon, Shubham Pant, Ecaterina E Ileana Dumbrava, Siqing Fu, David S Hong, Shizhen Zhang, Ming Sun, Yunfang Jiang, Jason Roszik, Juhee Song, Ying Yuan, Funda Meric-Bernstam, Aung Naing

Faculty, Staff and Student Publications

BACKGROUND: Sapanisertib (CB-228/TAK-228) is a potent, selective ATP-competitive, dual inhibitor of mTORC1/2. Metformin is thought to inhibit the mTOR pathway through upstream activation of 5'-AMP-activated protein kinase (AMPK) suggesting combination therapy may enhance antitumor activity of sapanisertib. We report preliminary safety, tolerability, and efficacy from the dose-escalation study of sapanisertib in combination with metformin in patients with advanced solid tumors.

METHODS: Patients with advanced metastatic solid tumors resistant or refractory to standard treatment, with and without mTOR/AKT/PI3K pathway alterations, received sapanisertib 3 or 4 mg daily together with metformin once to three times daily (500-1,500 mg). All patients underwent 14-day …


Food Labeling: Ingredient Exemptions And Product Claims, Elena Krasovkaia, Bradley J. Rickard, Brenna Ellison, Brandon R. Mcfadden, Norbert Wilson Feb 2024

Food Labeling: Ingredient Exemptions And Product Claims, Elena Krasovkaia, Bradley J. Rickard, Brenna Ellison, Brandon R. Mcfadden, Norbert Wilson

Agricultural Economics and Agribusiness Faculty Publications and Presentations

New breeding methods have provided scientists with opportunities to improve traits in a wide range of crops, however, there remains resistance to foods that are produced from these crops, and mandates on labels used to describe such processes continue to be a source of policy debate. Here we focus on gene editing and examine (i) whether consumer acceptance varies when the technology is applied to different ingredients (unrefined versus highly refined ingredients) and (ii) the impact of two different claims related to gene editing (health-focused claim versus an environment-focused claim). Our results show that consumers are less likely to purchase …


Mindfulness Resources In The Academic Library, Rebecca Maynite, Beryl White-Bing, Lauren Odom, Robin Mcneil Feb 2024

Mindfulness Resources In The Academic Library, Rebecca Maynite, Beryl White-Bing, Lauren Odom, Robin Mcneil

Library Faculty Presentations & Publications

Listeners describe "tingles" as the ASMR experience, but many others enjoy ASMR even if they don't get tingles. ASMR videos have grown in popularity over the years. Recently, they made a resurgence on TikTok, even in parody form (think of the viral Mercedes ASMR video and all of the responses). Becca and Robin have utilized ASMR videos for relaxation and stress-management for the past 10 years. Beryl and Becca thought this could be a great resource for students.


Heterogeneity In Maternal Mrnas Within Clutches Of Eggs In Response To Thermal Stress During The Embryonic Stage, Atsuko Sato, Yukie Mihirogi, Christine Wood, Yutaka Suzuki, Manuela Truebano, John Bishop Feb 2024

Heterogeneity In Maternal Mrnas Within Clutches Of Eggs In Response To Thermal Stress During The Embryonic Stage, Atsuko Sato, Yukie Mihirogi, Christine Wood, Yutaka Suzuki, Manuela Truebano, John Bishop

School of Biological and Marine Sciences

Background: The origin of variation is of central interest in evolutionary biology. Maternal mRNAs govern early embryogenesis in many animal species, and we investigated the possibility that heterogeneity in maternal mRNA provisioning of eggs can be modulated by environmental stimuli. Results: We employed two sibling species of the ascidian Ciona, called here types A and B, that are adapted to different temperature regimes and can be hybridized. Previous study showed that hybrids using type B eggs had higher susceptibility to thermal stress than hybrids using type A eggs. We conducted transcriptome analyses of multiple single eggs from crosses using eggs …


The Effect Of Breastfeeding Practices Of Undernourished Mothers In Rural Sierra Leone On Infant Growth And Mortality, Aminata Shamit Koroma, Kevin B Stephenson, Per O Iversen, Mark J Manary, David Taylor Hendrixson Feb 2024

The Effect Of Breastfeeding Practices Of Undernourished Mothers In Rural Sierra Leone On Infant Growth And Mortality, Aminata Shamit Koroma, Kevin B Stephenson, Per O Iversen, Mark J Manary, David Taylor Hendrixson

2020-Current year OA Pubs

Breastfeeding provides optimal infant nutrition; however, <50% of infants are exclusively breastfed (EBF) for 6 months. We aimed to describe breastfeeding practices and their effects on growth and mortality among a high-risk mother-infant cohort in rural Sierra Leone. This was a secondary analysis of data from a randomized nutrition intervention trial among undernourished pregnant women. The study's primary outcomes were infant weight and length gains at 6 weeks of age. We included 1270 singleton infants in the analysis, with 1092 (85.6%) having 24-week outcome data. At 6 weeks, 88% were EBF, but the rate of EBF decreased to 17% at 24 weeks. The EBF infants at 6 weeks had improved length (difference of 0.9 mm/week; 95% CI 0.4 to 1.3;