Digital Commons Network^™

Azacitidine As Epigenetic Priming For Chemotherapy Is Safe And Well-Tolerated In Infants With Newly Diagnosed Kmt2a-Rearranged Acute Lymphoblastic Leukemia: Children's Oncology Group Trial Aall15p1, Erin M. Guest, John A Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew J. Carroll, Nyla A. Heerema, Holly R. Kubaney, Margaret A. August, Sidharth Ramesh, Byunggil Yoo, Midhat S. Farooqi, Melinda G. Pauly, Daniel S. Wechsler, Rodney R. Miles, Joel M. Reid, Cynthia D. Kihei, Lia Gore, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Patrick A. Brown

Manuscripts, Articles, Book Chapters and Other Papers

Infants less than 1 year old diagnosed with KMT2A-rearranged (KMT2A-r) acute lymphoblastic leukemia (ALL) are at high risk of failure to achieve remission, relapse, and death due to leukemia, despite intensive therapies. Infant KMT2A-r ALL blasts are characterized by DNA hypermethylation. Epigenetic priming with DNA methyltransferase inhibitors increases the cytotoxicity of chemotherapy in preclinical studies. The Children's Oncology Group trial AALL15P1 tested the safety and tolerability of 5 days of azacitidine treatment immediately prior to the start of chemotherapy on day 6, in four post-induction chemotherapy courses for infants with newly diagnosed KMT2A-r ALL. The treatment was well-tolerated, with only …

Guidelines On Management Of Hereditary Polyposis Syndromes In Pediatric Patients: Agreement, Disagreement And Where It Matters, Taina Hudson, Claudia Phen, Isabel Rojas, Shlomi Cohen, Warren Hyer, Thomas M. Attard

Manuscripts, Articles, Book Chapters and Other Papers

Hereditary polyposis syndromes are rare but potentially devastating conditions which require multidisciplinary care from an early age. Societal guidelines, which ideally combine expert opinions and medical evidence, serve as the framework for disease diagnosis, surveillance and treatment. However, there is a significant underrepresentation of pediatric gastroenterology input in guideline formulation, and additionally, recommendations can vary significantly between societies, which can have a moderate-to-high clinical impact on patient care. This paper aims to summarize key differences in management based on societal guidelines and identify some of the factors which may contribute to divergence in care in hereditary polyposis syndromes in pediatric …

Advocating For More Personalized And Evidence-Based Approaches In Dental Practice, Integrating Advanced Diagnostic Tools And Innovative Treatments To Enhance Patient Care, Hasanuddin, Acing H. Mude, Muhammad Ikbal, Erni Marlina, Muhammad Ruslin

Journal of Dentomaxillofacial Science

This editorial review highlights a series of studies emphasizing evident discoveries in the diagnosis and treatment of oral diseases. The first report addresses a rare case of unicystic ameloblastoma located in the maxillary sinus, highlighting the need of histological analysis for precise identification despite deceptive radiographic characteristics. A different example examines dentigerous cysts, highlighting diagnostic problems stemming from unusual appearances, finally clarified by histological assessment. The effectiveness of sclerotherapy with hypertonic saline for treating parotid sialocele is examined, indicating it as a safe and efficacious therapeutic alternative. The influence of anemia on pediatric drug-induced erythema multiforme is examined, highlighting the …

Adverse Childhood Experiences And Early Life Adversity And Their Effects On Chronic Health: A Literature Review, Ella Weatherford

The Eleanor Mann School of Nursing Undergraduate Honors Theses

With more than 439,000 annual U.S. deaths associated with childhood adversity, it is important to understand and prevent exposure to Adverse Childhood Events and Early Life Adversity. The purpose of this literature review is to identify and examine the pathophysiology between adverse childhood experiences (ACE’s) and their negative effects on health across the lifespan. Fifteen peer-reviewed articles that were published in notable journals were analyzed to include in this review. The results of these articles show that Adverse Childhood Experiences and Early Life Adversity can lead to the development of chronic inflammatory conditions across the lifespan. Using Barker Hypothesis and …

Characterizing The Usda-Npgs Germplasm Collection Of Tartary Buckwheat (Fagopyrum Tataricum), Noah Joseph Abasciano

Master's Theses and Capstones

AbstractTartary buckwheat (Fagopyrum tataricum) is a promising underutilized crop in the context of New England’s rapidly changing environment (USDA NH State Profile, 2022). Despite substantive prior work on the genetics and nutrition of Tartary buckwheat (Zhang et al., 2017b), many practical questions pertaining to its potential cultivation in New England remain unanswered. This thesis presents the first systematic genotypic and phenotypic screening of the USDA National Plant Germplasm System's (NPGS) Tartary buckwheat germplasm collection in an effort to lay the foundations for future crop improvement efforts. The genotypic assessment of the NPGS Tartary buckwheat germplasm was completed by first bottlenecking …

The Impact Of Hospital Protocol For Severe Alcohol Use Disorder, Meredith Jones

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: Alcohol use disorder remains a prevalent condition within current society. For a smaller, but ever growing population, alcohol use evolves into a severe, addictive disease process. Individuals managing this disorder can suffer from acute withdrawals and further comorbidities causing eventual detriment. Medical institutions attempt to combat withdrawal with varying forms of treatment, utilized to manage symptoms and further issues “as needed.” As this condition becomes increasingly more pervasive within casual society, hospitals’ fragmented attempts to manage this disease process proves to be ineffective for this patient population.

Purpose: The purpose of this systematic review is to analyze current methods …

The Show Must Go On: Leading Factors In The Burnout Of Stage Managers, Morgen E. Doyle

Honors College Theses

Stage managers are the key to making theatre move onstage and in the audience. To keep the show, we need to take care of our stage managers. Many have voiced concerns about burnout from their time in the stage management industry (McGraw 2024, 12). Burnout can be defined as “a syndrome conceptualized as resulting from chronic workplace stress that has not been successfully managed” and characterized by three main dimensions: “energy depletion and exhaustion; feelings of cynicism and increased mental distance related to the individual’s job; and reduced professional efficiency in the individual’s workplace” (World Health Organization 2019). In this …

Assessing General Propulsion Architectures For Fast Transit Times To Mars For Crewed Missions, Vivek Bhatt

Doctoral Dissertations and Master's Theses

As NASA and commercial contractors, such as SpaceX, continue to develop their programs with Artemis and Starship, respectively, it is becoming more and more apparent that the program developments are ultimately for finding a way to put humans onto Mars. However, when we approach the current timeline of going to Mars, it usually involves a 6-9 month one way trip. Due to this, human spaceflight to Mars becomes more dangerous as exposure to affects such as solar radiation, long exposure to low gravity fields, and isolation. These are some of the many hazards that come with interplanetary space travel for …

Integrated Transcriptomics And Proteomics Study Of Starvation Selected Drosophila Melanogaster, Aavash Adhikari

UNLV Theses, Dissertations, Professional Papers, and Capstones

Drosophila melanogaster, selected for starvation resistance exhibits phenotypic traits such as increased body size, slower development, reduced fecundity and obesity like characteristics including higher lipid reserves and cardiac dysfunction. While prior studies have explored the metabolic and biochemical changes in these flies, the underlying genetic and molecular mechanisms remain unclear. This study aims to investigate the gene expression and protein abundance in starvation-selected Drosophila through RNAseq, proteomics, and integrating both datasets using the MixOmics package in R. I found differential gene expression in the fat body at the third instar larval stage, particularly in pathways related to lipid metabolism, calcium …

Biological Reduction Of Mixed Oxyanions In Wastewater Brine, Katherine J. Earp

UNLV Theses, Dissertations, Professional Papers, and Capstones

Treatment of contaminated brine water is an area of active research spurred by the use of advanced treatment technologies, such as membrane separation, reverse osmosis, ion exchange, etc. for water reuse and recycling, which has become critical due to the impact of climate change on water resources throughout the globe. Biological reduction of harmful organic and inorganic pollutants in water has been demonstrated as an effective method for water and wastewater treatment and would be a potential technology for brine treatment. However, biodegradation of contaminants in high salinity waters is challenging because most microbial communities cannot survive brine environments. The …

Understanding Levels Of Perceived Racism And Discrimination When Utilizing Perinatal Care, Alexandria S. Evans

UNLV Theses, Dissertations, Professional Papers, and Capstones

Social and structural determinants of health, grounded in historical racism and discrimination, significantly influence maternal health outcomes. Because of this, communities of color experience a higher burden of maternal health disparities. In the last several decades, there has been an increased awareness of the need to integrate critical race theory into public health research to address maternal health disparities in the context of perinatal care delivery, policy, and funding decisions.

This three-manuscript dissertation utilized mixed methods to examine the ways in which systemic racism and discrimination are perceived and how it impacts the utilization of perinatal care services in historically …

Self-Regulated Learning Through Self-Concordant Goals, Social Modeling And Sustainability Focus, Oana Mandrutiu-Iancu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Research has shown that when students spend time reflecting and autonomously selecting their college goals, they show high intrinsic motivation, low extrinsic motivation and improvement in emotional and social adjustment over the first several months of college. Despite of this, it is estimated that 77% of first- and second-year students are undecided on their major and many remain undecided as they transition into their junior and senior year. Moreover, in education settings the primary emphasis is on academic success, but focusing solely on academic goals is limiting. As learning is inherently social, academic and social domains cannot be separated, while …

Chronic Illness Education 2024: Tackling Childhood Obesity Using The Chronic Care Model, Avan Chu, Bassem Chamma, Katiya Barkho, Ryan Li, Sabrina Pakula, Zoe Raphael

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Educational Resources For Families To Improve Childhood Obesity, Arianna Arcenas, Colton Clymer, Henry Li, Jonathan Albrecht, Kathleen Girdler, Saleh Ahmed

Patient Education Projects

No abstract provided.

Potential Ethanol Extracts Of Super Red Dragon Fruit Peel And Flesh For Detecting Dental Plaque, Euis R. Yuslianti, Dewi Li. Nasution, Nadya S. Pramita

Journal of Dentomaxillofacial Science

Objective: Dental plaque is a collection of microorganisms that adhere to surface of tooth and can cause various health problems in oral cavity. To detect plaque on surface of teeth, a coloring agent such as a disclosing solution is needed. As an alternative ingredient that does not harm, this study used super red dragon fruit peel and flesh (Hylocereus costaricensis) which is high levels of anthocyanins and natural coloring agents that can be used as alternative materials for detecting plaque on surface of tooth.

Material and Methods: The research methode were quasi-experimental design research with a post-test control …

Assessing The Impact Of An Individual Diabetic Education Program And Big Data App On Three Generations Of Patient Populations, Avery C. Carpenter, Rechendia C. Carpenter, Ester M. Felipe

Doctoral Projects

Diabetes is a chronic condition that affects numerous people worldwide. Diabetic education assists people with understanding the nature of diabetes, its side effects and how to successfully deal with the condition. The doctoral project incorporates finding out how glucose monitoring, prescription administration, dieting propensities, and the significance of customary activities. With proper education the impact on one’s health with this chronic condition can improve for the better.

The nature of this doctoral project is to assess the impact that a diabetic education program and big data app have on three generations. Members of the group partnered with Hutton Healthcare in …

Chain Extension Of Blocked Isocyanates For The Creation Of Covalent Adaptable Networks, Catherine Sarantes

Dissertations

From mattresses to car coatings, polyurethanes and polyureas (PUs) are ubiquitous thermoset materials with tunable thermo-mechanical performance. This tunability is afforded through the extent of crosslinking or covalent linkages established by the formation of urea bonds. Traditionally, urea bonds are highly stable yet through the blocked isocyanate, hindered urea bond (HUB) mechanism this bond is thermally labile allowing for re-processing of normally non-recyclable PU materials. The overarching focus of my dissertation is the exploration synthetic pathways to access secondary diamines to enable re-processing of covalent adaptable networks (CANs) with tunable re-processing through the diamine moiety and the molecular weight of …

Toxic Narratives, Toxic Communities, And Enforcement Of Environmental (In)Justice, Alyse Bertenthal

Washington Law Review

The United States has committed to enforce environmental justice in ways it never has before. A spate of new policies aims to increase resources for environmental agencies’ enforcement sections, improve training for environmental enforcement staff, and ensure community engagement in environmental enforcement decision-making. Yet there exists mounting evidence that enforcement of environmental laws happens less frequently and less vigorously in low-income and minoritized communities.

We need to understand why that is happening. Many commentators, opining from a distance, point to insufficient resources for environmental enforcement and legal and political constraints on environmental agencies. While not discounting these reasons, this Article …

Detection Of Apiary Sites From Remote Imagery, Ning Li

Theses and Dissertations

Honey bees are essential for honey production and pollination services, but their colonies have been declining despite increasing demand. This decline may be due to various factors, including habitat loss, altered land use, climate shifts, and pesticide exposure. In order to assess the quantity and quality of habitats for honey bees and determine their availability and suitability for supporting bee colonies, it is crucial to identify the spatial location of registered apiary sites being used. However, such data is not available, which makes it a challenge for researchers in the field to further advance honey bee-related investigations. In my study, …

Guidelines For The Standardization Of Pre-Analytical Variables For Salivary Biomarker Studies In Alzheimer's Disease Research: An Updated Review And Consensus Of The Salivary Biomarkers For Dementia Research Working Group, Ted K. S. Ng, Chinedu Momoh, Mei-Ann Lim, Helena Sophia Gleerup, Wayne Leifert, Catherine Ajalo, Nicholas Ashton, Henrik Zetterberg, Robert A. Rissman, Charisse N. Winston

Brain and Mind Institute

There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement blood and cerebrospinal fluid and detect various analytes. An interdisciplinary, international group of AD and related dementias (ADRD) researchers convened and performed a narrative review of published studies on salivary AD biomarkers. We critically appraised the current state of the literature, examining both consistencies and discrepancies in existing pre-analytical variables and methodologies. We discussed how various pre-analytical variables …

Black Lives Still Matter: Freedom Schools As An Embodiment Of Critical Literacy Through Reflection And Action, Elena M. Venegas, Lakia M. Scott

Bilingual and Literacy Studies Faculty Publications

The continuation of racial inequities in the United States has ignited the recent Black Lives Matter Movement, a protest of police brutality and gun violence. Black lives matter in public school classrooms, too—where students of color face barriers to equitable educational experiences. The Children's Defense Fund Freedom School program is a major component in developing critical literacy skills through critique, inquiry, and transformation through social justice and action. Critical literacy is enacted through identity—mainly as difference, self, consciousness, narrative, and positionality. Historical and contemporary relevance of Freedom Schools connects to the urgency of the Black Lives Matter Movement.

Predictive Model For Listeria Monocytogenes In Rte Meats Using Exclusive Food Matrix Data, N.A. Nanje Gowda, Manjari Singh, Gijs Lommerse, Saurabh Kumar, Eelco Heintz, Jeyamkondan Subbiah

Food Science Faculty Publications and Presentations

Post-processing contamination of Listeria monocytogenes has remained a major concern for the safety of ready-to-eat (RTE) meat products that are not reheated before consumption. Mathematical models are rapid and cost-effective tools to predict pathogen behavior, product shelf life, and safety. The objective of this study was to develop and validate a comprehensive model to predict the Listeria growth rate in RTE meat products as a function of temperature, pH, water activity, nitrite, acetic, lactic, and propionic acids. The Listeria growth data in RTE food matrices, including RTE beef, pork, and poultry products (731 data sets), were collected from the literature …

Measuring Palatability Of Pet Food Products: Sensory Components, Evaluations, Challenges, And Opportunities, Natalia Calderon, Brittany L. White, Han-Seok Seo

Food Science Faculty Publications and Presentations

The pet food industry is a growing business launching a variety of new products in the market. The acceptability or preference of pet food samples has traditionally been measured using either one-bowl or two-bowl tests. Academic researchers and professionals in the pet food industry have explored other methods, including the cognitive palatability assessment protocols and the ranking test, to evaluate more than two samples. A variety of approaches and perspectives were also utilized to predict palatability and key sensory attributes of pet foods, including descriptive sensory analysis by human-trained panelists and pet food caregivers’ perceptions of pet food. This review …

A Single Session Of Acceptance And Commitment Therapy In A Group Format To Promote Health-Related Behavior Change In Nutrition And Sleep: A Randomized Controlled Trial, Thi Anh Tran

Dissertations

Nutrition and sleep are important health-related behaviors for which only a small percentage of the population meet recommended guidelines. To impact population-health it is important to develop focused, flexible, efficient, and efficacious interventions. This study examined the efficacy of a 60-minute Acceptance and Commitment Therapy (ACT) intervention in a group presentation format to initiate change in nutrition and sleep related behaviors in college students. Thirty-two collegians (M age = 18.55 [.85], 66% female, 34% Hispanic, 25% white) were randomized to receive ACT focusing on nutrition (n = 18 participants across 4 groups) or sleep (n = 14 participants across 3 …

Body Positivity Via Costuming Performances In Grades Nine Through Twelve Dance, Kacey Valentine O'Keeffe

Master's Theses

This thesis explored the impact of body image and self-esteem on high school dancers and the pivotal role of dance educators in fostering a positive environment during concert preparations. The purpose of this research study was to determine if there was a correlation between promotion of health and wellness from dance educators and body positivity among high school dancers. The following research questions were addressed in this study:

Q1 What positively contributes to a dancers’ self-esteem and body image?

Q2 What is an effective solution for costume fitting methods to be used by dance educators while keeping their dancers’ safety …

A Proposed Instrument To Determine Mobility Eligibility Criteria And Levels For Mechanically Ventilated Patients In The Intensive Care Unit, Keira Gabrielle Miller

Doctoral Scholarly Projects & Capstones

Immobility is a problem among mechanically ventilated patients in the intensive care unit. Early mobility has been shown to benefit mechanically ventilated patient outcomes by minimizing hospital stays and costs, decreasing the risk of infection, and improving muscle strength to lead to a better quality of life. No inclusive checklists exist to evaluate patients progressing to varying levels of mobility based on specific criteria such as hemodynamics, neurological function, and disease acuity. This gap was identified after a current and comprehensive literature review on early mobilization among mechanically ventilated patients. The purpose of this project was to combine a comprehensive …

Assessing Impact Risk To Tropical Marine Ecosystems From Human Activities With A Southeast Asian Example, Fiona Culhane, Melanie C. Austen, Matthew Ashley, Jonson Javier, Sui Hyang Kuit, Nguyen Phuc Hung, Hau Duc Tran, Radisti A. Praptiwi, Sainal Sainal, Eva Justine, Prawesti Wulandari, Stefanie Broszeit, Jean Beth Jontila, Sofia Johari, Lota Creencia, Amy Yee Hui Then, Lea Janine Gajardo, Carya Maharja, Hong Ching Goh, Wan Mohd Syazwan, Yang Amri Affendi, Lê Ngọc Thảo, Jito Sugardjito, Tom Mullier, Olivia Langmead

School of Biological and Marine Sciences

Society relies on intact marine ecosystems for ecosystem services such as nutrition, livelihoods, health and well-being. Yet, to obtain these benefits, we carry out activities, introducing pressures to ecosystems, damaging and degrading habitats and reducing their capacity to optimally provide ecosystem services. Biodiversity and ecosystem services are consequently being lost globally but impact chains from these activities are poorly understood, especially in tropical marine ecosystems. We identified for the first time impact chains linking activities with pressures they introduce in five tropical coastal and marine habitats, specifically through application in four Southeast Asian case study sites. Using expert elicitation based …

Exploring The Relationship Between Nutrition-Related Attitudes And Use Of Scrappy’S Cupboard Among College Students At The University Of Tennessee At Chattanooga, Emma Rosenberger

Honors Theses

Introduction This thesis examines the relationship between nutrition-related attitudes and the use of Scrappy’s Cupboard, a campus food pantry, among undergraduate and graduate students at the University of Tennessee at Chattanooga (UTC). This study aims to determine how students’ attitudes toward nutrition influence their likelihood of utilizing campus food resources, highlighting differences between users and non-users of Scrappy’s Cupboard. A correlation between nutrition-related attitudes and the use of Scrappy's Cupboard was expected, with pantry users reporting more positive attitudes towards nutrition compared to non-users. Methods A survey was administered to UTC students to assess their nutrition-related attitudes, food pantry usage, …

Victims Unknown: An Evaluation Of The Way Louisville, Kentucky Communicated About Aids At The End Of The 20th Century, Alexander M. Vernon

Electronic Theses and Dissertations

This is thesis examines the way that printed news sources reported on AIDS during the height of the epidemic in Louisville, Kentucky. It compares between mainstream and grass-roots sources to work to identify shortcomings in reporting, and how reporting on a public health crisis can be improved upon in the future. It uses an intersectional framework to deconstruct why certain news sources reported on specific demographics of the population, across racialized and gendered lines. Chapter One analyzes the epidemic and then contextualizes the language that was used. Chapter Two focuses on mainstream local newspapers, while also defining demographics of AIDS …

Access To Health Care And Glycemic Control: The National Health And Nutrition Examinations Survey (Nhanes) 2005-2018., Mohamed M. Ali

Electronic Theses and Dissertations

Background and Purpose: Diabetes mellitus is a chronic metabolic condition associated with numerous medical and financial sequences. In 2018, 34.1 million adults aged 18 years or older had diabetes in the U.S. Access to Care for diabetic Americans remains a public healthcare concern. This study aims to examine the relationship between access to healthcare and selected diabetes indicators. Methods: A quantitative, repeated cross-sectional study uses four of the National Health and Nutrition Examinations Survey's (NHANES) access measures (insurance, the number of times of annual healthcare visits, routine place for healthcare, and type of place) and four diabetes indicators (Hemoglobin A1C …