Digital Commons Network^™

Transition To Enteral Triazole Antifungal Therapy For Pediatric Invasive Candidiasis: Secondary Analysis Of A Multicenter Cohort Study Conducted By The Pediatric Fungal Network, Robert F T Bucayu, Craig L K Boge, Inci Yildirim, Martha Avilés-Robles, Surabhi B Vora, David M Berman, Tanvi S Sharma, Lillian Sung, Elio Castagnola, Debra L Palazzi, Lara Danziger-Isakov, Dwight E Yin, Emmanuel Roilides, Gabriela Maron, Alison C Tribble, Pere Soler-Palacin, Eduardo López-Medina, José Romero, Kiran Belani, Antonio C Arrieta, Fabianne Carlesse, Dawn Nolt, Natasha Halasa, Daniel Dulek, Sujatha Rajan, William J Muller, Monica I Ardura, Alice Pong, Blanca E Gonzalez, Christine M Salvatore, Anna R Huppler, Catherine Aftandilian, Mark J Abzug, Arunaloke Chakrabarti, Michael Green, Irja Lutsar, Elizabeth D Knackstedt, Sarah K Johnson, William J Steinbach, Brian T Fisher, Rachel L Wattier

Faculty, Staff and Students Publications

Of 319 children with invasive candidiasis, 67 (21%) transitioned from intravenous to enteral antifungal therapy. Eight (12%) transitioned back to intravenous antifungal therapy, one due to perceived treatment failure defined by clinical progression or worsening. Global treatment response at study completion was successful in 66 participants who transitioned to enteral therapy.

Orthogonal And Multiplexable Genetic Perturbations With An Engineered Prime Editor And A Diverse Rna Array, Qichen Yuan, Hongzhi Zeng, Tyler C Daniel, Qingzhuo Liu, Yongjie Yang, Emmanuel C Osikpa, Qiaochu Yang, Advaith Peddi, Liliana M Abramson, Boyang Zhang, Yong Xu, Xue Gao

Faculty, Staff and Students Publications

Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation. mvGPT can precisely edit human genome via PE coupled with a prime editing guide RNA and a nicking guide RNA, activate endogenous gene expression …

The Role Of Psychological Well-Being In Reducing Competition Stress Among Junior Artistic Gymnasts, Baida'a Tariq Abdul-Wahid

Modern Sport

The objective of the study was to develop two scales: one for psychological well-being and another for competition stress among junior artistic gymnasts. It aimed to assess the level of psychological well-being among these gymnasts, determine the level of competition stress they experience, and explore the role of psychological well-being in reducing competition stress. The hypothesis posited that there is a significant correlation, contribution, and impact of the psychological well-being scale results on the competition stress scale results within the research sample. The descriptive approach using the correlational relationships method was adopted, targeting a sample of junior artistic gymnasts for …

Impact Of Chia Seed Ingestion And Physical Activity On Insulin Resistance And Triglyceride Levels In Men And Women, Ali Abdulraheem Jabbar, Maysaa Jalal Majeed, Muataz Fawzi Hussein

Modern Sport

The Chia seeds are a herbaceous plant native to southern Mexico and Guatemala. They have many nutritional and medicinal uses because they contain fibers, minerals and vitamins. These components have a significant impact on insulin resistance, which is considered a source of risk for many diseases, most notably type 2 diabetes. High levels of triglycerides. It is considered a source of danger for many diseases, the most important of which is heart disease. This study aims to evaluate the effect of consuming chia seeds on parameters of insulin resistance and triglyceride levels in individuals who suffer from insulin resistance. The …

The Effect Of Cardio Exercises On Cholesterol, Low-Density Lipoproteins (Ldl), And Body Mass Index In Women Aged 30–35 Years, Shahad Haitham Sheet, Israa Fouad Saleh

Modern Sport

The importance of the research was achieved through practicing cardio exercises, which work to modify cholesterol levels and low-density lipids in the body, in addition to reducing the body mass index in the research sample, represented by women aged 30-35 years. The research problem lies in the fact that high levels of cholesterol and low-density lipoproteins (LDL) in the blood are among the most prominent risk factors leading to cardiovascular diseases. This health problem is especially important for women, as they face hormonal changes associated with aging and menopause, which affect blood fat levels and increase the likelihood of fatty …

The Effect Of Varying Training Volumes On Developing Maximum Speed, Measuring Certain Mineral Levels In The Body, And Performance In The Men’S 100-Meter Sprint, Fahim Abdul-Wahid Eesa

Modern Sport

The importance of the research: This study aims to design training exercises that vary training volume from different starting positions over various distances, allowing sufficient time for physical recovery between repetitions and sets. Through the researcher's modest experience, a weakness was observed in the ability to reach maximum speed. Periodic laboratory tests, which assist coaches in assessing players' health status and have a direct impact on performance in the 100-meter sprint event, were also highlighted. The experimental program was used in the research procedures, and a sample of elite 100-meter male sprinters in Iraq, consisting of (12) athletes, was tested. …

Effectiveness Of An Online Food Shopping Intervention To Reduce Salt Purchases Among Individuals With Hypertension - Findings Of The Saltswitch Online Grocery Shopping (Ogs) Randomised Trial, Jason Hy Wu, Damian Maganja, Liping Huang, Kathy Trieu, Fraser Taylor, Eden M Barrett, Clare Arnott, Xiaoqi Feng, Aletta E Schutte, Gian Luca Di Tanna, Cliona Ni Mhurchu, Adrian J Cameron, Mark D Huffman, Bruce Neal

2020-Current year OA Pubs

BACKGROUND: Online grocery shopping is a growing source of food purchases in many countries. We investigated the effect of nudging consumers towards purchases of lower sodium products using a web browser extension.

METHODS: This trial was conducted among individuals with hypertension who shopped for their groceries online in Australia. From July 2021 to June 2023, participants were randomised to use the SaltSwitch Online Grocery Shopping web browser extension or continue their usual grocery shopping for 12 weeks. The SaltSwitch extension modified a retailer's online shopping interface to suggest similar but lower sodium alternative products to those initially selected. The primary …

Food For Thought: A Qualitative Assessment Of Medical Trainee And Faculty Perceptions Of Nutrition Education, Olivia Kunitsky, Mahdi Taye, Karla Feeley, Hugh Johnson, Abigail Glynn, Avery Stivale, Matthew Hamers, Alexis Notarianni, Sireesha Mamillapalli, Gabi Waite, Sonia Lobo

Department of Neurology Faculty Papers

BACKGROUND: The American Society of Clinical Nutrition recommends 37 to 44 h of undergraduate medical nutrition education. The Total Health Curriculum at Geisinger Commonwealth School of Medicine (GCSOM) contains 14 h of objective-based nutritional instruction. This study aimed to examine the perceptions of key stakeholders regarding the role of nutrition in medicine and to identify barriers, opportunities for improvement, and roles/responsibilities for innovative implementation of nutrition education.

METHODS: This exploratory, qualitative study employed a phenomenological approach and inductive coding process. Purposive sampling recruited medical students, undergraduate medical education (UME) faculty, physicians, and other healthcare professionals at GCSOM and affiliated clinical …

Cultural Adaptation And Environmental Challenges: A Case Study Of Nubian Communities In Egypt Through The Lens Of Cultural Ecology Theory, Imam Wicaksono, Sherif Sa’Ad Algayyar, Ahmed Hassan Mohammad Hassan

Journal Of Middle East and Islamic Studies

The purpose of this study is to investigate how the ecological changes brought about by the building of the Aswan Dam have affected the Nubian community's social structure, cultural identity, and coping mechanisms. The study emphasizes how important it is to comprehend how people interact with their surroundings considering modernization, which frequently jeopardizes the viability of regional customs. In addition to a literature review approach, a thematic analysis grounded in Julian Steward's cultural ecology theory—which highlights how societies adjust to changes in their physical surroundings—was used. The results show that ecological changes have profoundly impacted the Nubian people's cultural rites, …

Understanding Women, Infant And Children Feeding Decisions In Emergencies: The Case Of Covid-19 And The Formula Shortage, Davida Mensah, Edmund F. Agyemang, Constance Gewa

School of Mathematical & Statistical Sciences Faculty Publications

Background: The advantages of breastfeeding and its role in emergencies are undeniable. Studies show that many women in developed countries choose formula over breastmilk, even in emergencies. Nevertheless, no one knows if postpartum women under the Women, Infants and Children (WIC) program turned out to breastfeed or re-lactate their infants during these crises. This study aims to better understand WIC participants' perceptions about breastfeeding their babies in emergencies.

Methods: A chi-square test of independence was used to assess the association between breastfeeding choice and demographic characteristics and potential covariates of respondents. A post hoc analysis using Dunn's multiple comparisons test …

Promotion Of Overall Health During The Adolescent Period For Adolescent Girls Through Teaching Program – A Quasi-Experimental Study, Anusuya V. Prabhu Mrs., Sangeetha Priyadarshini, Mamatha Shivananda Pai Dr., Yashoda Sathish Dr.

Manipal Journal of Nursing and Health Sciences

Background

Adolescence, characterized by physical, psychological, and behavioral transformations, often elicits varied responses from girls. Adequate data can aid them in navigating these changes effectively. The study aimed to assess adolescent girls' understanding of puberty, psychological transitions, reproductive health, and the importance of a balanced diet during this developmental stage.

Method:

In this quasi-experimental investigation, purposive sampling was utilized to gather data. The study comprised 184 teenage girls aged between 10 and 19, with 92 participants assigned to both the intervention and control groups. Data were collected using a pre-designed questionnaire consisting of thirty-one questions aimed at assessing knowledge of …

Perception Of Nursing Care Among Patients And Nurses In Neuro Units Of Selected Settings In Chennai., Kanwaljeet Kaur, Deepa M, Dr. Sudha R

Manipal Journal of Nursing and Health Sciences

Introduction: Nurses are the health experts because they are caregivers, advocates, and educators. Patient is the Centre of nursing practice. Nurses provide care to patients from admission till discharge and gives more time to patients and their families as compared to other health care workers. This is the reason that nurses influence the patient perception about hospital care at most. Objective: The aim of this study was to Assessment of perception on nursing care provided among patients and nurses in neuro units of selected settings, Chennai. Methods: A quantitative research approach with a descriptive cross-sectional design was adopted for the …

Global Standards And Protocols For Oral Care In Pediatric Cancer Patients: Systematic Review Protocol, Meghna Pandit, Baby S. Nayak, Vasudeva K. Bhat, Suneel C. Mundkur, Judith A. Noronha, Sridhar N

Manipal Journal of Nursing and Health Sciences

Introduction Childhood cancer is a global health challenge, with over 275,000 cases annually among individuals under 19 years. Cancer treatments such as chemotherapy and radiation therapy lead to significant oral complications, including mucositis, xerostomia, and infections, adversely affecting treatment adherence and quality of life. Effective oral care is essential for mitigating these complications, particularly in resource-limited settings like India.

Objectives This systematic review aims to identify, assess, and summarize global guidelines and protocols for oral care in pediatric cancer patients, focusing on the prevention and management of oral complications during treatment.

Methods The protocol adheres to PRISMA-P guidelines and is …

Refereed Research: A Sufficientarian Approach To Consumption Ethics In The Face Of Climate Change, Srinivas Venugopal, Ronika Chakrabarti

Subsistence Marketplaces

In this paper, we adopt a sufficientarian ethics approach to study the concern of consumption inadequacy engendered by climate change in subsistence communities. The sufficientarian approach to consumption ethics dictates that in the face of climate change, priority should be afforded to establishing and maintaining consumption adequacy in low-income settings. We elaborate on the basic principles underlying sufficientarian ethics and compare it to alternative approaches such as utilitarian ethics and prioritarian ethics. Subsequently, we turn our attention toward specifying how poverty and the deleterious impact of climate change combine to render subsistence communities more vulnerable to consumption inadequacies as compared …

From Surviving To Thriving: Key Considerations For Weight Control Across Diverse Cancer Survivorship Populations, Justin C. Brown, Marlyn Allicock, Carmina G. Valle, Tanya Agurs-Collins

School of Medicine Faculty Publications

BACKGROUND: Obesity is a chronic, relapsing, progressive disease of excess adiposity that increases the risk of dying from at least 16 types of cancer. The prevalence of obesity has increased more rapidly in cancer survivors compared with the general population. Tailored weight management strategies are needed to improve prognosis and health outcomes in the growing population of cancer survivors. However, certain cancer survivor population subgroups require unique consideration when developing weight management strategies. METHODS: In a symposium convened by The Obesity Society during ObesityWeek 2023 titled "From Surviving to Thriving: Key Considerations for Weight Control Across Diverse Cancer Survivorship Populations," …

How Ngos Operationalize The Ecological Capability Approach To Achieve Sustainability Goals, Patrick Elven P. Bañaco, Maria Assunta C. Cuyegkeng

Journal of Management for Global Sustainability

This study explores how NGOs achieve sustainability goals as they focus on poverty alleviation through ecological capability building. In-depth semi-structured interviews with nine representatives of NGOs working on poverty alleviation were conducted and subjected to thematic analysis within a critical realist perspective. Findings show that the NGOs engage their communities in all the different stages of their programs, creating a sense of empowerment that becomes the foundation for their ecological meta-capability, a holistic approach to the development of human capability that considers social, economic, and environmental aspects. This is better understood by analyzing the interplay of Structure, Agency, and Culture …

Exploring Predictors Of Purchase Intention Toward Plant-Based Meat, Kristiana Ginelle D. Monares, Ken Sean D. Roque, Melissa A. Santos, Sofia Marianne S. So, Catherine A. Valentin, Alvin Patrick M. Valentin

Journal of Management for Global Sustainability

Plant-based meat (PBM) presents itself as a sustainable alternative to meat production systems that have adversely impacted consumers’ health and the environment at large. In the Philippine context, however, there are only a few PBM manufacturers to date even though production has been emerging with expanded options for consumers to consider. Moreover, while PBM’s potential allows it to be a prospective working food system in the country through the promotion of healthier food chains, the literature on PBM in the Philippines is scant. This study thus contributes to this literature by exploring predictors of purchase intention toward PBM. The researchers …

Documentary On Floating Wetlands, Nazish Abro

MSJ Capstone Projects

I created this documentary on floating wetlands as part of a climate project led by the Student Society of Climate Change during my degree program. This project is a competition among South Asian countries to find solutions for climate change. My team, PK Team 22 from IBA Karachi, is among the top three teams in Pakistan and has reached the final round. The top two teams will receive a US fellowship and seed funding to continue their work.

We received $200 from the US Consulate to complete the second phase of our project. I chose this topic not only for …

Folic Acid And Methyltetrahydrofolate Supplementation In The, Karen E Christensen, Marie-Lou Faquette, Daniel Leclerc, Vafa Keser, Yan Luan, Jeanna L Bennett-Firmin, Olga V Malysheva, Alaina M Reagan, Gareth R Howell, Marie A Caudill, Teodoro Bottiglieri, Rima Rozen

Faculty Research 2024

Background/Objectives: The MTHFR677C>T gene variant results in a thermolabile MTHFR enzyme associated with elevated plasma homocysteine in TT individuals. Health risks associated with the TT genotype may be modified by dietary and supplemental folate intake. Supplementation with methyltetrahydrofolate (methylTHF) may be preferable to folic acid because it is the MTHFR product, and does not require reduction by DHFR to enter one-carbon folate metabolism. In the Mthfr677C>T mouse model for this variant, female 677TT (TT) mice have an increased incidence of hepatic steatosis. The objective of this study was to compare the effects of methylTHF and folic acid supplementation …

Preparedness And Practice Competency In Tracheostomy Management By Speech Language Pathologists In Saudi Arabia, Shabeer A. Abdul Samadh, Muhannad Aljabli

Journal of Medical Rehabilitation Science

The scope of practice by Speech language pathologists in tracheostomy management in patients with or without mechanical ventilation is continuously expanding. Despite this expanding scope, less is known on what is being done throughout the SLPs academic and professional practice in order to achieve competencies and quality practice.

This study aimed to identify the preparations, clinical consistencies and current practice patterns among the Speech language pathologists while treating tracheostomy patients with and without mechanical ventilator within the kingdom of Saudi Arabia. The questionnaire adapted with approval from the authors, Ward et al., (2007, 2008 and 2012) and McGowan et al, …

Swimming Against The Tide: Resistance Strategies And Agentic Skills Used By Childfree Women, Carolina Rojas-Madrigal

Journal of Feminist Scholarship

In pronatalist societies, the decision to remain childfree creates a conflict-laden scenario. This article explores how childfree women confront social hostility and defend their reproductive autonomy through resistance strategies and tactics. With this aim, the results of a feminist research, positioned from feminist Standpoint theory and digital ethnography, are presented. The researcher conducted biographical-narrative interviews with sixteen voluntary childless women from Mexico, Guatemala, Costa Rica, Ecuador, Peru, Spain, and the United Kingdom, all of whom were members of a childfree Facebook group. This research revealed that there is a persistent tension between societal pressure placed on these women in pronatalist …

Energy Saving Technology For Drying Garlic (Allium Sativum), Jasur Esirgapovich Safarov, Shakhnoza Abduvaxitovna Sultanova, А M. Mirkomilov

Technical science and innovation

Food drying is a widely used preservation method aimed at reducing water content to extend shelf life, decrease weight, and enhance storage efficiency. This process, particularly in garlic, involves rapid initial moisture loss followed by a slower phase due to the increasing difficulty of extracting residual water. Drying methods include natural solar drying and advanced mechanical techniques such as hot air and vacuum drying, each influencing product quality, drying efficiency, and economic feasibility. Dehydrated garlic exhibits specific sensory, physico-chemical, and microbiological characteristics, making it suitable for various applications, including powder production. Advanced drying equipment optimizes air volume, temperature, and material …

Supporting Holistic Health And Gestational Diabetes Mellitus Risk Reduction Among Young Native Females Prior To Pregnancy: A Qualitative Exploration., Sarah A. Stotz, Luciana E. Hebert, Lisa Scarton, Kelli Begay, Kelly L. Gonzales, Heather Garrow, Melanie Charley, Melanie Aspaas, Denise Charron-Prochownik, Spero M. Manson

OHSU-PSU School of Public Health Faculty Publications and Presentations

AI/AN communities are disproportionately impacted by food insecurity and gestational diabetes mellitus (GDM). Decreasing the risk of GDM can interrupt the intergenerational cycle of diabetes in AI/AN families, and can decrease diabetes-related health disparities. The goal of this study was to explore ways of supporting holistic health and reducing the risk of GDM among young American Indian and Alaska Native (AI/AN) females prior to pregnancy. Semi-structured interviews were conducted with adult AI/AN women (>18 years) who had GDM or who have young female relatives (e.g., daughters) (n = 41), AI/AN females between 12 and 24 years (n = 18), …

Activity Performance Priorities For Adults Experiencing Homelessness: Insights From Management And Staff At A Transitional Housing Facility, Bernard Austin Kigunda Muriithi

Communication Disorders and Occupational Therapy Faculty Publications and Presentations

For people experiencing homelessness (PEH), the provision of affordable housing has been recognized as the most crucial intervention for improving housing stability and facilitating substance abuse treatment. However, evidence indicates that providing housing does not significantly improve substance abuse, mental health, or physical health outcomes. Optimal participation in essential daily activities has been shown to improve health outcomes and support independent living, but there is limited research that identifies activity performance priorities among PEH living in transitional housing. The present study investigates activity performance priorities using the focus group methodology. Management and staff from a transitional housing facility participated in …

Bayesian Semiparametric Inference In Longitudinal Metabolomics Data, Abhra Sarkar, Ornella Cominetti, Ivan Montoliu, Joanne Hosking, Jonathan Pinkney, Francois Pierre Martin, David B. Dunson

Peninsula Medical School

The article is motivated by an application to the EarlyBird cohort study aiming to explore how anthropometrics and clinical and metabolic processes are associated with obesity and glucose control during childhood. There is interest in inferring the relationship between dynamically changing and high-dimensional metabolites and a longitudinal response. Important aspects of the analysis include the selection of the important set of metabolites and the accommodation of missing data in both response and covariate values. With this motivation, we propose a flexible but parsimonious Bayesian semiparametric joint model for the outcome and the covariate generating processes, making novel use of nonparametric …

Va Dent J July, August And September 2023

Virginia Dental Journal

The July-September 2023 issue of the Virginia Dental Journal (Vol. 100, No. 3) showcases diverse and timely topics in dentistry. Highlights include the launch of the Virginia Dental Academy’s Certified Dental Office Professional program, designed to elevate front office team members through specialized training and certifications. Advocacy efforts spotlight the ADA Dentist and Student Lobby Day and fundraising events for legislative priorities. Scientific discussions delve into oral pathology and periodontics, while practice management resources cover cybersecurity, insurance verification, and informed consent ethics. A standout feature is Tooth Sleuths, an engaging look at how dentists apply investigative skills to solve …

Parents Perceptions On The Efficacy Of Common Autism Interventions: A Case Study In Stockton And Lodi California, Jacqueline D. Fox, Lindsay Gietzen

Pacific Journal of Health

A neurological and developmental disability that impacts how people receive information and interact with outside stimuli is known as autism spectrum disorder (ASD). Autism can be characterized by a wide range of symptoms. For children diagnosed with autism, there are numerous therapy options available. The purpose of this study was to find out how effective parents perceived some of the most common autism interventions given to their children were. The interventions included ABA therapy, speech & language therapy, cognitive behavioral therapy, pharmacological, nutrition and educational therapies. Out of all the participants, only one reported a significant improvement in their child …

Administrators’ Perceptions Of Minoritized Students’ Underrepresentation In K-8 Gate, Vernice Verona Sharpe

Walden Dissertations and Doctoral Studies

The purpose of this qualitative study was to understand SWSD administrators’ perceptions of the practices and identification criteria that exacerbated this underrepresentation, guided by a culturally responsive school leadership framework. For this basic qualitative design, eight SWSD administrators with direct knowledge of the GATE programs participated in semistructured interviews. Data analysis involved initial and axial coding, resulting in three key themes: limited cultural awareness among administrators, the importance of incorporating community perspectives, and the need to reevaluate traditional GATE identification practices. Based on these themes, it is recommended to enhance cultural competency training, to engage community members in decision-making, and …

Visualizing Parcel-Level Lead Risk Using An Exterior Housing-Based Index., Neal J. Wilson, Ryan Allenbrand, Elizabeth Friedman, Kevin Kennedy, Amy Roberts, Stephen Simon

Manuscripts, Articles, Book Chapters and Other Papers

Pediatric lead poisoning remains a persistent public health problem. Children in the US spend the preponderance of their time at home; thus, housing is an important social determinant of health. Improving health outcomes derived from housing-based sources involves differentiating the risks posed by the existing housing stock. In this paper, we developed a parcel-level lead risk index (LRI) based on external housing conditions and the year of home construction. The purpose of this study was to introduce a housing-based lead risk index (LRI), developed using retrospective data, to estimate parcel-by-parcel variation in housing-based lead risk. We described how the LRI …

Mock Trial Team Hosts Annual Chucky Mullins Invitational, Will Jones

University of Mississippi News

OXFORD, Miss. – Several University of Mississippi students earned honors during the fifth annual Chucky Mullins Invitational hosted recently by the university's Mock Trial Association at the School of Law.