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2024

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A Retrospective Review: Oxford County Wellness Collaborative's Contributions To Community Health, Emma Schwartz, Rachel M. Gallo Mph Jun 2024

A Retrospective Review: Oxford County Wellness Collaborative's Contributions To Community Health, Emma Schwartz, Rachel M. Gallo Mph

Children, Youth, & Families

Since 2011, Oxford County Wellness Collaborative (OCWC) has been transforming personal, environmental, and economic health by building strong relationships among people and organizations. OCWC contracted with the Data Innovation Project at the Catherine Cutler Institute of Health and Social Policy to synthesize previously collected or reported data and collect primary data to conduct a retrospective evaluation. The evaluation team used this data to convey past successes, better understand the outcomes of the collaborative to date, and provide recommendations for OCWC’s next steps in furthering its impact.


Exploring The Dual Impact: Dissecting The Impact Of Tourism Agglomeration On Low-Carbon Agriculture, Qiang Zhou, Xinyue Ye, Alberto Gianoli, Wanrong Hou Jun 2024

Exploring The Dual Impact: Dissecting The Impact Of Tourism Agglomeration On Low-Carbon Agriculture, Qiang Zhou, Xinyue Ye, Alberto Gianoli, Wanrong Hou

Management Faculty Publications

Despite extensive research on the relationship between tourism and agriculture, the specific impact of tourism on agriculture's low-carbon transition has not been thoroughly investigated. This study analyzes the effects of tourism agglomeration on agricultural carbon intensity across 30 Chinese provinces from 2001 to 2020. It is framed within the context of rural digitalization, with a particular emphasis on the integration of agro-tourism and the total factor productivity of agriculture. Utilizing spatial econometric models, we find that tourism agglomeration hinders the low-carbon transition in agriculture by influencing carbon intensity both directly and indirectly. At the national level, the impact of …


Forage News [2024-06], University Of Kentucky Jun 2024

Forage News [2024-06], University Of Kentucky

Forage News

No abstract provided.


Innovative Housing Solutions: A Toolkit To Utilizing Recycled Spaces As Transition Shelters For The Unhoused, Kristel Jened Alianza Mallari Jun 2024

Innovative Housing Solutions: A Toolkit To Utilizing Recycled Spaces As Transition Shelters For The Unhoused, Kristel Jened Alianza Mallari

City and Regional Planning

Increasingly, the challenges of homelessness in urban areas have necessitated innovative solutions that leverage existing infrastructure. This project explores how repurposing underutilized spaces, such as vacant offices and hotels, into transitional shelters can provide immediate relief and long-term support for unhoused individuals. By focusing on inclusive design and strategic planning, this toolkit offers a comprehensive approach to addressing homelessness through adaptive reuse of existing buildings.

Urban areas in the United States face a persistent homelessness crisis exacerbated by economic instability, lack of affordable housing, and systemic barriers. Traditional shelters often fail to provide the necessary support for long-term stability, highlighting …


“Whale Wars” — Are The Japanese Whaling Just Because They Can? A Testament Of Failed International Whaling Policy, Katy Rotzin Jun 2024

“Whale Wars” — Are The Japanese Whaling Just Because They Can? A Testament Of Failed International Whaling Policy, Katy Rotzin

UC Law SF International Law Review

This paper analyzes whaling law and practices in Japan. This paper briefly compares Japanese whaling to whaling in Norway and Iceland, as well as Indigenous whaling but mainly focuses on Japan’s domestic ethos around “whaling culture,” their policies, which perpetuate whaling even though the industry is no longer profitable, and their unique relationship with the International Whaling Commission. This paper further analyzes the International Whaling Commission’s main document, the International Convention for the Regulation of Whaling, and its inability to keep rogue nations in check, and recommends that anti-whaling nations combine both soft law and sanctions to pressure Japan to …


Cognitive Reserve, Cortisol, And Alzheimer's Disease Biomarkers: A Memory Clinic Study, Manasa Yerramalla, Alexander Darin-Mattsson, Chinedu Momoh, Jasper Holleman, Ingemar Kåreholt, Malin Aspö, Göran Hagman, Miia Kivipelto, Alina Solomon, Anna Marseglia Jun 2024

Cognitive Reserve, Cortisol, And Alzheimer's Disease Biomarkers: A Memory Clinic Study, Manasa Yerramalla, Alexander Darin-Mattsson, Chinedu Momoh, Jasper Holleman, Ingemar Kåreholt, Malin Aspö, Göran Hagman, Miia Kivipelto, Alina Solomon, Anna Marseglia

Brain and Mind Institute

INTRODUCTION Cognitive reserve might mitigate the risk of Alzheimer's dementia among memory clinic patients. No study has examined the potential modifying role of stress on this relation.

METHODS We examined cross-sectional associations of the cognitive reserve index (CRI; education, occupational complexity, physical and leisure activities, and social health) with cognitive performance and AD-related biomarkers among 113 memory clinic patients. The longitudinal association between CRI and cognition over a 3-year follow-up was assessed. We examined whether associations were influenced by perceived stress and five measures of diurnal salivary cortisol.

RESULTS Higher CRI scores were associated with better cognition. Adjusting for cortisol …


Manage Crop Weeds At Harvest, Department Of Primary Industries And Regional Development, Western Australia Jun 2024

Manage Crop Weeds At Harvest, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

This management strategy provides an opportunity to control weed seed set in the pasture and during harvest. The strategy physically removes viable seed from the paddock by collecting weed seed and grazing crop residues.

Weed seed removal at harvest can be achieved in 2 ways:

1. collecting weed seeds from the system to prevent them being spread across the paddock or farm

2. grazing weed contaminated crop residue and pastures.


Atep 536.01: Foundations In Athletic Training, Mitchell Willert Jun 2024

Atep 536.01: Foundations In Athletic Training, Mitchell Willert

University of Montana Course Syllabi, 2021-2025

No abstract provided.


The Effect Of Probiotic Supplementation On Serum Metabolite Concentrations In Young Holstein Heifers, Emily G. Meissner Jun 2024

The Effect Of Probiotic Supplementation On Serum Metabolite Concentrations In Young Holstein Heifers, Emily G. Meissner

Master's Theses

The objective of this trial was to evaluate the effect of a multi-strain probiotic on serum concentrations of selected metabolites in young calves. Holstein heifers (n = 112) from a commercial dairy were enrolled within 48 h of birth and placed into individual hutches. Calves were weaned at 60 d of age and remained in their hutches until 90 d of age, when they were moved to group housing. Calves were placed into 2 treatment groups: 1) control and 2) B. subtilis, B. lichenformis, L. animalis, and P. freudenreichii probiotic (Bovamine Dairy Plus, Chr. Hansen, Milwaukee, WI). Control calves received …


Preference Of Dhurrin-Free Sorghum By Ewes, Shelby M. Gruss, Keith D. Johnson, John Scott Radcliffe, Ronald P. Lemenager, Mitchell R. Tuinstra Jun 2024

Preference Of Dhurrin-Free Sorghum By Ewes, Shelby M. Gruss, Keith D. Johnson, John Scott Radcliffe, Ronald P. Lemenager, Mitchell R. Tuinstra

Animal and Food Sciences Faculty Publications

Sorghum [Sorghum bicolor (L.) Moench] is a resilient forage crop due to its drought tolerance and adaptation to low-N environments. Sorghum produces a cyanogenic glucoside called dhurrin. The breakdown of dhurrin leads to the release of hydrogen cyanide (HCN), which can cause cyanide toxicity in livestock. Dhurrin-free sorghum lines have been developed through chemical mutagenesis by mutagenizing the gene for the first enzyme, CYP79A1, in the biosynthetic pathway. The CYP79A1 mutation was bred into sorghum lines to create a dhurrin-free experimental hybrid. Grazing preference of ewes was assessed when allocated to the dhurrin-free hybrid and three commercial hybrids. Near isogenic …


A Survey Of Perceptions And Expectations Of Hospital Pharmacists To The Roles Of Ward-Based Pharmacists In Thailand, Siddhibhong Jongkraijakra, Tanavij Pannoi, Kansamorn Wongsiripolkul, Kanchanok Aengchuan, Phurit Saisap Jun 2024

A Survey Of Perceptions And Expectations Of Hospital Pharmacists To The Roles Of Ward-Based Pharmacists In Thailand, Siddhibhong Jongkraijakra, Tanavij Pannoi, Kansamorn Wongsiripolkul, Kanchanok Aengchuan, Phurit Saisap

The Thai Journal of Pharmaceutical Sciences

Background: Ward-based pharmacists have fostered patient-centered care. In 2011, the Pharmacy Council of Thailand established the standard criteria for pharmacist practitioners. Nevertheless, Thailand still needs to clarify the perceptions and expectations of ward-based pharmacists’ roles. Objectives: This study aimed to explore the perceptions and expectations of ward-based pharmacists’ roles among Thailand’s hospital pharmacists. Materials and Methods: The method was a cross-sectional study conducted with a director of the pharmacy department or a representative among tertiary and secondary hospitals under the supervision of the Ministry of Health in Thailand. The questionnaires were divided into four sections: the first section covered information …


A Narrative Review Of Polycystic Ovarian Syndrome, Prudence A. Rodrigues, M. Madhusri, M. Anjali Jun 2024

A Narrative Review Of Polycystic Ovarian Syndrome, Prudence A. Rodrigues, M. Madhusri, M. Anjali

The Thai Journal of Pharmaceutical Sciences

A common endocrine-gynecology problem affecting many women is polycystic ovary syndrome (PCOS). The precise etiology and pathophysiology of PCOS have not yet been fully understood, despite the discovery of some of the relevant mechanisms in its formation. We looked up the etiology, pathophysiology, diagnostic procedures, and therapy of PCOS in PubMed. All the causative elements of PCOS were carefully examined. This disease affects women from the time of conception until death, putting their health at risk and lowering their quality of life. In addition, it raises the morbidity and death rates. The earliest signs of PCOS appear throughout the puberty …


Unraveling The Potential Of Natural Anti-Obesity Agents: An Insight, Naveen Kumar, Pranav Shah, Shweta Agarwal Jun 2024

Unraveling The Potential Of Natural Anti-Obesity Agents: An Insight, Naveen Kumar, Pranav Shah, Shweta Agarwal

The Thai Journal of Pharmaceutical Sciences

This review delves into the contemporary advancements and research on anti-obesity agents sourced from natural origins. Obesity, a pressing global health concern, necessitates effective interventions due to its association with various comorbidities such as hypertension and diabetes. Scientific data gathered from databases including PubMed and Scopus, as well as search engines such as Google and Google Scholar, focused on keywords such as “anti-obesity agents,” “herbal anti-obesity agents,” and “mechanism of action of anti-obesity agents.” The review highlights the escalating research efforts toward formulating safe and efficient dosage forms to combat obesity, with synthetic agents often linked to adverse effects. Natural …


Architecture As A Carbon-Based Practice, Qixin Yu Jun 2024

Architecture As A Carbon-Based Practice, Qixin Yu

Masters Theses

Carbon serves as both a silent protagonist and a looming antagonist in the narrative of architecture, shaping not only the physical structures we inhabit but also the ecological legacy we leave behind.

Centuries of human exploitation of the environment have led to climate and material crises. Shifting this dynamic requires action at micro (matter), meso (material), and macro (materiality) levels. Biogenic materials offer significant potential for carbon sequestration and present opportunities for the building industry to collaborate with nature rather than merely extract from it.

This thesis establishes a research and manufacturing practice that prioritizes material innovation, carbon sequestration, environmental …


Evaluations Of Exercise Intolerance With Cardiopulmonary Exercise Tests In A 24-Year-Old Young Male With Obesity With Tetrahydrobiopterin Deficiency: A Case Report, Chun-Yu Chen, Shin-Tsu Chang, Ko-Long Lin, Mu-Hsun Wu Jun 2024

Evaluations Of Exercise Intolerance With Cardiopulmonary Exercise Tests In A 24-Year-Old Young Male With Obesity With Tetrahydrobiopterin Deficiency: A Case Report, Chun-Yu Chen, Shin-Tsu Chang, Ko-Long Lin, Mu-Hsun Wu

Rehabilitation Practice and Science

Phenylketonuria (PKU) is a rare amino acid metabolism genetic disorder. Tetrahydrobiopterin (BH4) metabolism defects cause variant PKU. BH4 coenzyme deficiency disables phenylalanine metabolism into tyrosine, causing brain damage and intellectual impairment. Patients follow a low-phenylalanine diet for life, increasing the risk of obesity, hypertension, and metabolic syndrome. A 24-year-old male patient with BH4 deficiency underwent a pulmonary function test and cardiopulmonary exercise test (CPET). Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were within normal values, with an 80.68% ratio. The 20-watt bicycle exercise test indicated moderate functional impairment (27.3 ml/kg/min of peak oxygen intake). The …


Sustaining Sustainable Farming: An Evaluation Of The Reasoned Action And Comprehensive Action Determination Frameworks For Persistence, Jet J. Tan Jun 2024

Sustaining Sustainable Farming: An Evaluation Of The Reasoned Action And Comprehensive Action Determination Frameworks For Persistence, Jet J. Tan

Master's Theses

This paper investigates the persistence of agricultural practices funded by the California Department of Food and Agriculture's Office of Environmental Farming and Innovation (CDFA OEFI). The central inquiry revolves around determining the most effective behavior model for analyzing persistence, comparing the Reasoned Action Approach (RAA), Comprehensive Action Determination Model (CADM), and CADM augmented with structural variables. The study's methodology integrates literature review, analysis of OEFI-funded practices, and statistical modeling to assess persistence levels. Contrary to existing literature, our findings reveal significantly higher levels of persistence than anticipated. Moreover, through model comparison, CADM augmented with political economic variables emerges as the …


International Society Of Sports Nutrition Position Stand: Ketogenic Diets, Alex Leaf, Jeffrey A. Rothschild, Tim M. Sharpe, Stacy T. Sims, Chad J. Macias, Geoff G. Futch, Michael D. Roberts, Jeffrey R. Stout, Michael J. Ormsbee, Alan A. Aragon, Bill I. Campbell, Shawn M. Arent, Dominic P. D'Agostino, Michelle T. Barrack, Chad Kerksick, Richard B. Kreider, Douglas S. Kalman, Jose Antonio Jun 2024

International Society Of Sports Nutrition Position Stand: Ketogenic Diets, Alex Leaf, Jeffrey A. Rothschild, Tim M. Sharpe, Stacy T. Sims, Chad J. Macias, Geoff G. Futch, Michael D. Roberts, Jeffrey R. Stout, Michael J. Ormsbee, Alan A. Aragon, Bill I. Campbell, Shawn M. Arent, Dominic P. D'Agostino, Michelle T. Barrack, Chad Kerksick, Richard B. Kreider, Douglas S. Kalman, Jose Antonio

Faculty Scholarship

Position statement

The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the use of a ketogenic diet in healthy exercising adults, with a focus on exercise performance and body composition. However, this review does not address the use of exogenous ketone supplements. The following points summarize the position of the ISSN:

1. A ketogenic diet induces a state of nutritional ketosis, which is generally defined as serum ketone levels above 0.5 mM. While many factors can impact what amount of daily carbohydrate intake will result in these levels, a broad guideline is a daily dietary …


Quality And Establishment Of Some Water-Conserving Turfgrass Species For Sustainable Development And Some Ecosystem Services In Arid Urban Environments, Fatemeh Kazemi, Mahmood Reza Golzarian, Seyedeh Maliheh Rabbani Kheir Khah Jun 2024

Quality And Establishment Of Some Water-Conserving Turfgrass Species For Sustainable Development And Some Ecosystem Services In Arid Urban Environments, Fatemeh Kazemi, Mahmood Reza Golzarian, Seyedeh Maliheh Rabbani Kheir Khah

Research outputs 2022 to 2026

Turfgrasses are essential landscape plants with social, environmental, and aesthetic services for urban ecosystems. However, more is needed to know how to establish them so that they can benefit from their ecosystem services in urban environments. This research examined some quality and morphological and physiological factors for the establishment and social and environmental service assessment of three warm-season turfgrasses, including Kikuyu grass (Pennisetum clandestinum), bermuda grass (Cynodon dactylon), and buffalo grass (Buchloe dactyloides), compared to the cool-season grass of tall fescue (Festuca arundinacea Schreb.). The experiment was split-plot in time, based on a randomized complete block design with eight replications. …


Carbon Dioxide Availability In Inlands Rivers Is Driven By Dissolved Organic Carbon, Not Warming: A Case Study Of Tigris River, Batool Kadhim, Mohammed Hamdan Jun 2024

Carbon Dioxide Availability In Inlands Rivers Is Driven By Dissolved Organic Carbon, Not Warming: A Case Study Of Tigris River, Batool Kadhim, Mohammed Hamdan

Baghdad Science Journal

Rivers became supersaturated with carbon dioxide (CO2), so they play an essential role in the global carbon budgets. To increase our understanding of the source of CO2 availability in rivers, we studied the role of climate-changed drivers of CO2 availability, which are ‘‘dissolved organic carbon (DOC), and warming’’. We sampled 45 locations of 3 parts within the Tigris River in Baghdad during autumn and winter. The results showed that all the studied variables (water temperature, pH, DOC, CO2) changed over time. The variations in CO2 availability are associated with changes in DOC concentration, not with water temperature. Overall, our results …


Non-Invasive Brain Stimulation As Treatment For Motor Impairment In People With Parkinson's Disease: Protocol For An Umbrella Review, Dale M. Harris, Steven J. O'Bryan, Christopher Latella Jun 2024

Non-Invasive Brain Stimulation As Treatment For Motor Impairment In People With Parkinson's Disease: Protocol For An Umbrella Review, Dale M. Harris, Steven J. O'Bryan, Christopher Latella

Research outputs 2022 to 2026

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder that predominantly affects movement and currently has no cure. Alongside medication, non-invasive brain stimulation (NIBS) may be used as an adjunct therapy to attenuate the motor symptoms experienced by people with PD. However, there is considerable heterogeneity in the evidence exploring the effects of NIBS for improving aspects of physical function in people with PD. Therefore, this protocol paper will outline the objectives, structure and procedure of a proposed umbrella review which will comprehensively summarise and map the current body evidence on the effectiveness of NIBS for improving physical function in …


Atep 588.50: Healthcare Administration & Leadership In Athletic Training, Valerie J. Moody Jun 2024

Atep 588.50: Healthcare Administration & Leadership In Athletic Training, Valerie J. Moody

University of Montana Course Syllabi, 2021-2025

No abstract provided.


The Metamorphoses Of Racial Discrimination In American Real Estate, Stevie J. Swanson Jun 2024

The Metamorphoses Of Racial Discrimination In American Real Estate, Stevie J. Swanson

Minnesota Journal of Law & Inequality

No abstract provided.


Selection Of Host Plants For Production Of Clanis Bilineata (Lepidoptera: Sphingidae), Xiaofeng Li, Mingming Guo, Kebin Li, Song Li, Honglin Feng, Jiwei Fan Jun 2024

Selection Of Host Plants For Production Of Clanis Bilineata (Lepidoptera: Sphingidae), Xiaofeng Li, Mingming Guo, Kebin Li, Song Li, Honglin Feng, Jiwei Fan

Faculty Publications

Clanis bilineata Walker (Lepidoptera: Sphingidae), a burgeoning edible insect, is experiencing rising demand in China and other regions. Despite this interest, larval production is currently constrained by the limitations of artificial production technologies, particularly the selection of optimal host plants. This study rigorously evaluated the performance of C. bilineatha larvae on four main host plants: round-leaf soybean, pointed-leaf soybean, black locust, and kudzu. Preference tests demonstrated that the larvae were most attracted to black locust (34.76 ± 4.65%), with subsequent preferences for kudzu (25.00 ± 6.12%), round-leaf soybean (23.17 ± 2.79%), and pointed-leaf soybean (14.02 ± 4.74%). No significant preference …


Pea Leaf Weevil, Sitona Lineatus (L.) (Coleoptera: Curculionidae), Adult Feeding Preference And Larval Development On Pulse Crop Varieties In Montana, Pragya Kiju, Kevin W. Wanner, Michael Ivie, Kevin Mcphee, Gadi V.P. Reddy Jun 2024

Pea Leaf Weevil, Sitona Lineatus (L.) (Coleoptera: Curculionidae), Adult Feeding Preference And Larval Development On Pulse Crop Varieties In Montana, Pragya Kiju, Kevin W. Wanner, Michael Ivie, Kevin Mcphee, Gadi V.P. Reddy

Faculty Publications

BACKGROUND: Montana accounts for approximately 45% of US dry pea production and the pea leaf weevil (PLW; Sitona lineatus (L.)) is the most common insect pest in this region. After crop emergence adult PLW feed on the foliage to mature and subsequently mate, and the soil-dwelling larvae feed and develop on the nitrogen-fixing root nodules. Producers commonly apply prophylactic insecticide treatments to the seed at planting as well as one or two post-emergent insecticide sprays to control PLW damage. To develop alternative management strategies based on integrated pest management (IPM), this field study evaluated pulse crops grown in Montana for …


Hepatic Interoception In Health And Disease, Hans Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison, Winfried L. Neuhuber Jun 2024

Hepatic Interoception In Health And Disease, Hans Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison, Winfried L. Neuhuber

Division of Basic Science Faculty Publications

The liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific sensory and motor components of both vagal and spinal access pathways to the hepatic parenchyma is missing. Lack of progress …


Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated Via Ahr Activation At The Air-Blood Interface, Ankit Aryal, Ashlyn C. Harmon, Kurt J. Varner, Alexandra Noël, Stephania A. Cormier, Divine B. Nde, Peter Mottram, Jemiah Maxie, Tammy R. Dugas Jun 2024

Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated Via Ahr Activation At The Air-Blood Interface, Ankit Aryal, Ashlyn C. Harmon, Kurt J. Varner, Alexandra Noël, Stephania A. Cormier, Divine B. Nde, Peter Mottram, Jemiah Maxie, Tammy R. Dugas

Division of Basic Science Faculty Publications

Particulate matter (PM) containing environmentally persistent free radicals (EPFR) is formed by the incomplete combustion of organic wastes, resulting in the chemisorption of pollutants to the surface of PM containing redox-Active transition metals. In prior studies in mice, EPFR inhalation impaired endothelium-dependent vasodilation. These findings were associated with aryl hydrocarbon receptor (AhR) activation in the alveolar type-II (AT-II) cells that form the air-blood interface in the lung. We thus hypothesized that AhR activation in AT-II cells promotes the systemic release of mediators that promote endothelium dysfunction peripheral to the lung. To test our hypothesis, we knocked down AhR in AT-II …


Anoctamin 4 Defines Glucose-Inhibited Neurons In The Ventromedial Hypothalamus, Longlong Tu, Yanlin He, Yong Xu Jun 2024

Anoctamin 4 Defines Glucose-Inhibited Neurons In The Ventromedial Hypothalamus, Longlong Tu, Yanlin He, Yong Xu

Division of Basic Science Faculty Publications

No abstract provided.


Estrogen Counteracts Age-Related Decline In Beige Adipogenesis Through The Nampt-Regulated Er Stress Response, Jooman Park, Ruoci Hu, Yanyu Qian, Shaolei Xiong, Asma Sana El-Sabbagh, Meram Ibrahim, Jaden Wang, Ziqiao Xu, Zhengjia Chen, Qing Song, Zhenyuan Song, Gege Yan, Abeer M. Mahmoud, Yanlin He, Brian T. Layden, Jiwang Chen, Sang Ging Ong, Pingwen Xu, Yuwei Jiang Jun 2024

Estrogen Counteracts Age-Related Decline In Beige Adipogenesis Through The Nampt-Regulated Er Stress Response, Jooman Park, Ruoci Hu, Yanyu Qian, Shaolei Xiong, Asma Sana El-Sabbagh, Meram Ibrahim, Jaden Wang, Ziqiao Xu, Zhengjia Chen, Qing Song, Zhenyuan Song, Gege Yan, Abeer M. Mahmoud, Yanlin He, Brian T. Layden, Jiwang Chen, Sang Ging Ong, Pingwen Xu, Yuwei Jiang

Division of Basic Science Faculty Publications

Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages that they offer are compromised with aging. Here we show that treating mice with estrogen (E2), a hormone that decreases with age, can counteract the age-related decline in beige adipogenesis when exposed to cold temperature while concurrently enhancing energy expenditure and improving glucose tolerance in mice. Mechanistically, we found that nicotinamide phosphoribosyl transferase (NAMPT) plays a pivotal role in facilitating the formation of E2-induced beige adipocytes, which subsequently suppresses the onset of age-related endoplasmic reticulum (ER) stress. Furthermore, we found that targeting NAMPT …


Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier Jun 2024

Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier

Division of Basic Science Faculty Publications

Aim: Type 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka ‘chow’) diets affects the onset and progression of hyperglycaemia in non-obese diabetic (NOD) mice. Methods: Female NOD mice were fed either unrefined diets or matched refined low- and high-fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group. Results: NOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high-fat diet had …


Associations Between Daily Step Count Classifications And Continuous Glucose Monitoring Metrics In Adults With Type 1 Diabetes: Analysis Of The Type 1 Diabetes Exercise Initiative (T1dexi) Cohort, Lauren V. Turner, Martin Chase Marak, Robin L. Gal, Peter Calhoun, Zoey Li, Peter G. Jacobs, Mark A. Clements, Corby K. Martin, Francis J. Doyle, Susana R. Patton, Jessica R. Castle, Melanie B. Gillingham, Roy W. Beck, Michael R. Rickels, Michael C. Riddell Jun 2024

Associations Between Daily Step Count Classifications And Continuous Glucose Monitoring Metrics In Adults With Type 1 Diabetes: Analysis Of The Type 1 Diabetes Exercise Initiative (T1dexi) Cohort, Lauren V. Turner, Martin Chase Marak, Robin L. Gal, Peter Calhoun, Zoey Li, Peter G. Jacobs, Mark A. Clements, Corby K. Martin, Francis J. Doyle, Susana R. Patton, Jessica R. Castle, Melanie B. Gillingham, Roy W. Beck, Michael R. Rickels, Michael C. Riddell

Clinical Research Faculty Publications

Aims/hypothesis: Adults with type 1 diabetes should perform daily physical activity to help maintain health and fitness, but the influence of daily step counts on continuous glucose monitoring (CGM) metrics are unclear. This analysis used the Type 1 Diabetes Exercise Initiative (T1DEXI) dataset to investigate the effect of daily step count on CGM-based metrics. Methods: In a 4 week free-living observational study of adults with type 1 diabetes, with available CGM and step count data, we categorised participants into three groups—below (< 7000), meeting (7000–10,000) or exceeding (>10,000) the daily step count goal—to determine if step count category influenced CGM metrics, including per cent time …