Digital Commons Network^™

Interview With Gina Apostol, Daryll Delgado

Kritika Kultura

No abstract provided.

Universal Basic Income Policy And Its Potential Impact On Welfare Reform, Adriana S. Hines, Lindsay Gietzen

Pacific Journal of Health

This systematic review synthesizes the current Universal Basic Income (UBI) research. As income inequality continues to affect health outcomes, UBI has been proposed as a strategy to reduce gaps in healthcare access, food security, housing, and overall well-being. The review examines 12 peer-reviewed articles to understand how UBI can impact the direct and indirect factors contributing to the disparities that the current welfare system may not adequately address. The findings indicate that UBI can help alleviate poverty-related stress, potentially leading to better mental and physical health outcomes through improved nutrition, more stable housing, and greater life satisfaction. Additionally, UBI has …

Preparing Spiritually Resilient Warriors In The Canadian Special Operations Forces Command, Vic Morris

Doctor of Ministry Major Applied Project

Morris, Victor E. “Preparing Spiritually Resilient Warriors in the Canadian Special Operations Forces Command.” Doctor of Ministry. Major Applied Project, Concordia Seminary, 2024. 285 pp.

The Canadian Armed Forces has outcomes and expectations for warriors to be spiritually resilient but does not have a training program that has been researched, tested, and validated to achieve this. This study investigates how chaplains can prepare spiritually resilient warriors in CANSOFCOM. A chaplain-led spiritual resilience course was created and delivered to CANSOFCOM members. The course was aligned with the holistic wellness strategy of OPF2, and designed as an inductive, experiential learning experience. An …

Horticulture Interventions Impact On Eating Disorder Symptoms, Taylor Kline

Counselor Education Capstones

Nature-based counseling offers a wide variety of options that counselors could incorporate into their session as a complementary form of counseling paired with another theory. Specifically, horticulture interventions have been found to increase clients’ self-efficacy and self-esteem, as well as reduce anxiety, which are all common symptoms of eating disorders. With the lack of research on horticulture interventions and the idea of utilizing them within the treatment of eating disorders, the contents of this paper aim to point out the variety of benefits of said interventions on common symptoms that are often related to eating disorders. Future research should focus …

The Burden Mothers Bear: Using The Health Belief Model To Understand How U.S. Mothers’ Intersectional Identities Shape Health Decision-Making During Covid-19, Sydney O'Shay, Kaitlin E. Phillips, Marissa J. Sáez

Publications

The disproportionate impact of COVID-19 on people of color and the burden placed on mothers created a need to better understand how mothers of color made health decisions for their families and communicated these decisions with others during the pandemic. This study investigated how this populations’ intersectional identities played a role in their health decision-making processes and overall experiences during COVID-19. Using the health belief model as a sensitizing concept, we conducted qualitative in-depth interviews with mothers of color across the United States about their lived experiences during the pandemic. Our findings suggest a need for health communicators to address …

Coastal Marine Heatwaves In The Santa Barbara Channel: Decadal Trends And Ecological Implications, Kit Yu Karen Chan, L. Kui, A. M. Mcdonald, A. L. Ritger, G. E. Hofmann

Biology Faculty Works

Marine heatwaves (MHWs) are of increasing concern due to the emerging ecological and socioeconomic impacts on coastal ecosystems. Leveraging the data of the Santa Barbara Coastal Long-Term Ecological Research project, we analyzed the MHW event metrics observed in the kelp forest ecosystem and across Santa Barbara Channel, CA, USA. Not only was there a significant positive trend in the number of MHWs recorded, their duration and intensity were also increasing over time. MHWs were detected year-round, suggesting that marine organisms have exposure risks regardless of their phenology. Exposure at one life history stage could have a legacy effect on the …

Tnf Prevents Establishment Of Anti-Tumor Immunity And Elucidates Toxicities Following Myxoma Virus Based Oncolytic Virotherapy, Miriam Beatriz Valenzuela Cardenas

Biomedical Sciences ETDs

Tumor Necrosis Factor Alpha (TNF) can lead to tumor regression through its direct cytolytic activity, yet it has also been implicated to facilitate tumor progression. This scenario complicates the efficacy and applicability of TNF based therapeutics as treatment for malignancies. In the context of oncolytic virotherapy (OV) which uses replicating viruses to treat tumors and acts by triggering production of pro-inflammatory cytokines, exploring such mechanisms is vital. Here we show that a Myxoma based oncolytic virus (vPD1/IL12) can induce large amounts TNF. The presence of TNF in the context of vPD1/IL12 plays a detrimental role both for tumor regression by …

5-Fluorouracil Induced Oxidative Stress Is Variable Across Triple Negative Breast Cancer Cell Lines, Rachel L. Walker

Departmental Honors & Graduate Capstone Projects

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with treatment limited to chemotherapy. However, not all patient tumors respond to chemotherapy. The variable cytotoxic effects of chemotherapies may be due to how cancer cells regulate reactive oxygen species (ROS). In this study, we examined two mouse breast cancer cell lines: 4T1 and EO771, vary when treated with hydrogen peroxide (H2O2) and 5-Fluorouracil (5FU), known ROS-inducing substances. In 4T1 cells H2O2 increased oxidized DNA but caused minimal cell death. While in EO771 cells that same amount of H2O2 caused complete apoptosis. Cell number, ROS, and cell death showed …

Decentralized And Divided: Philadelphia’S Public Assistance System And Community-Based Initiatives, Gianna Casey, Shari Orisich

Honors Theses

Public assistance programs and community-based initiatives have aided Philadelphian’s residents in a cohesive effort to fill the gaps of community-needs. While both are inherently different in their methodologies and executions, their structures are built upon a collective foundation of legislative principles and policy-based ordinances in Philadelphia. These concepts, first began with poor laws and religious organizations in the 19th century, have turned into a complex system that has fallen tremendously short of sufficiently addressing the specialized needs of Philadelphian families. The surrounding laws for public assistance program administration (e.g. TANF and WIC), are founded within the objectives of these poor …

Targeting Myeloid Cell Iron Metabolism In Salmonella-Induced Colitis, Mariella Arcos Padilla

Biomedical Engineering ETDs

Salmonellosis is a severe infection caused by Salmonella enterica serovar Typhimurium, leading to significant global morbidity and mortality.

Previous studies have shown that mice lacking the iron storage protein ferritin heavy chain (FTH1) in myeloid cells exhibit worsened Salmonella infection. Nuclear receptor co-activator 4 (NCOA4) directs FTH1 autophagic degradation to release iron from storage during conditions of low iron. However, the role of myeloid NCOA4 in regulating bacterial infections remains unclear.

Here, we found that myeloid NCOA4 deficiency augments spleen iron levels and increases cellular iron accumulation, oxidative stress, and ferroptosis in bone marrow-derived macrophages (BMDM) cells. This deficiency also …

Farmers’ Decision Processes About Biocontrol Innovation Adoption: Dynamics Surrounding Push-Pull Technology In Western Kenya, Olufemi Samson Adesina, Stephen Whitfield, Susannah M. Sallu, Steven M. Sait, Jimmy Pittchar

All Peer-Reviewed Publications

Smallholder farmers in sub-Saharan Africa (SSA) face increasing challenges from pests and climate change, among other issues. In response to these challenges, international agricultural research for development (R4D) investment is often focused on developing and scaling up techniques and technologies that bolster resilience. However, such approaches are often technocentric and follow linear assumptions of innovation diffusion and adoption, which overlook the complex realities that influence smallholder farmers’ dynamic decisions and engagement with novel techniques. This study used qualitative ethnographic methods to explore the experiences, knowledge construction, motivations, and decision-making of farmers in Western Kenya regarding the extensively researched push-pull technology …

Development, Progression, And Mortality Of Suspected Interstitial Lung Disease In Copdgene, Jonathan A Rose, Ann-Marcia C Tukpah, Claire Cutting, Noriaki Wada, Mizuki Nishino, Matthew Moll, Sean Kalra, Bina Choi, David A Lynch, Benjamin A Raby, Ivan O Rosas, Raúl San José Estépar, George R Washko, Edwin K Silverman, Michael H Cho, Hiroto Hatabu, Rachel K Putman, Gary M Hunninghake

Faculty, Staff and Students Publications

Rationale: Some with interstitial lung abnormalities (ILA) are suspected to have interstitial lung disease (ILD), a subgroup with adverse outcomes. Rates of development and progression of suspected ILD and their effect on mortality are unknown. Objectives: To determine rates of development, progression, and mortality in those with suspected ILD and assess effects of individual ILD and progression criteria.

Methods: Participants from COPDGene (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease) with ILA characterization and FVC at enrollment and 5-year follow-up were included. ILD was defined as ILA and fibrosis and/or FVC < 80% predicted. Prevalent ILD was assessed at enrollment and incident ILD and progression were assessed at 5-year follow-up. Computed tomography (CT) progression was assessed visually and FVC decline as relative change. Multivariable Cox regression tested associations between mortality and prevalent ILD, incident ILD, and progression groups.

Measurements and Main Results: Of 9,588 participants at enrollment, 268 …

The Role Of Nutrient Solutions On Phosphate-Solubilizing Bacteria Population, Phosphorus Availability, Phosphorus Uptake, Growth And Yield Of Red Chili (Capsicum Annuum L.), Betty Natalie Fitriatin, Raden Faqih Hilmiy Ghifari, Emma Trinurani Sofyan, Fitri Widiantini, Hanif Fakhrurroja, Tualar Simarmata

Jurnal Kultivasi

Red chili consumption in Indonesia has increased every year. However, with large chili production to meet large consumption, land conversion for various purposes has reduced the harvested area. The efforts to increase the harvested area of chili using Inceptisols soil by providing nutrient solutions to overcome the infertility of the soil using its nutrients. This experiment aims to determine the effect of nutrient solution application on the population of phosphate-solubilizing bacteria, phosphorus availability, phosphorus uptake, growth, and yield of Red Chili (Capsicum annuum L.) in Inceptisols. The experiment was conducted from August 2023 to February 2024 at Ciparanje Experimental Field, …

The Structure And Function Of A Coastal State Aquaculture Plan, C. R. Fong, C. M. Gonzales, M. Rennick, H. J. Lahr, L. D. Gardner, B. S. Halpern, H. E. Froehlich

Faculty Research, Scholarly, and Creative Activity

Aquaculture contributes approximately half of all global aquatic food production and will be critical in addressing future seafood demand, including the United States (U.S.). Many states, territories, and countries are developing and updating aquaculture specific policy in an effort to plan for, and better manage the expansion of aquaculture in their territorial waters. The U.S. has considerable potential to sustainably expand aquaculture production, which has been a focus in both federal and state policy. State aquaculture plans have been used for over 40 years to help plan and coordinate aquaculture development, with a growing emphasis on sustainability. Here, we located …

Impacts Of Gibberellin Application On Citrus: An Overview From Seed Germination To Fruit Quality Enhancement, Siti Auliya Rahma, Rahmat Budiarto, Syariful Mubarok, Supatida Abdullakasim

Jurnal Kultivasi

Gibberellins are key plant hormones, and their application in citrus plants is frequently reported. This review aims to provide an overview of the application of gibberellic acid (GA3) in citrus cultivation, emphasizing their effects on growth, flowering, fruit quality, and ripening. Citrus fruits often face challenges like irregular fruit set, size inconsistency, and environmental stress, impacting yield and profitability, with exogenous gibberellin application as a potential solution. Applying gibberellins can accelerate citrus seed germination and seedling growth, enhance vegetative growth, inhibit flowering, delay fruit ripening, and improve fruit quality. However, the efficacy of gibberellins varies across species and conditions, highlighting …

Cost-Effectiveness Analysis Of Pembrolizumab With Chemotherapy For Metastatic Nonsquamous Non-Small Cell Lung Cancer In Taiwan, Wei-Ling Lee, Wan-Hsuan Chou, Wei-Pin Chang, Tsung-Wei Chang, Chun-Nan Kuo, Wei-Chiao Chang

Journal of Food and Drug Analysis

This study was aimed to evaluate the cost-effectiveness of pembrolizumab with chemotherapy (pembrolizumabcombination therapy) and compare it with standard-of-care platinum-based chemotherapy (chemotherapy alone) as a first-line treatment for metastatic nonsquamous NSCLC from the perspective of Taiwan's third-party-payer public health-care system. We used a partitioned survival model with an estimated time horizon of 10 years. The partitionedsurvival model uses KaplaneMeier estimates of progression-free and overall survival from the KEYNOTE-189 clinicaltrial. The quality-adjusted life-year (QALY) values were based on utility values by progression status calculated from theKEYNOTE-189 trial. This study examined costs related to treatment regimens, disease management, second-line therapy,end-of-life care, and …

Fluorescent “On–Off–On” Sensor Based On N, P Co-Doped Carbon Nanoparticles For Specific Detection Of Fe3+ And Ascorbic Acid, Li Li, Ming Zhang, Xiang Liu, Shaoqing Zhu

Journal of Food and Drug Analysis

Ascorbic acid (AA) is used as a food additive for its antibacterial and antioxidant properties. However, excessive intake of AA is harmful to humans. Therefore, the detection of Fe³⁺ and AA is generally recognized to be meaningful. In this work, a one-step hydrothermal tactics is developed for the preparing nitrogen and phosphorus co-doped carbon nanoparticles (N, P-CNPs) by using sucrose and ammonium orthophosphate as raw materials. The N, P-CNPs not only exhibited an enhanced fluorescent efficiency with a relatively high quantum yield up to 28%, but also showed satisfactory stability, water solubility and photostability. The fluorescence of N, P-CNPs …

Aromatic Compounds And Organic Acids Identified From Ganoderma Formosanum Exhibit Synergistic Anti-Melanogenic Effects, Chen-Che Hsieh, Chih-Yao Hou, Hsiao-Yun Lei, Darin Khumsupan, Huey-Jine Chai, Pek-Kui Lim, Cheng-Chih Hsu, Sz-Jie Wu, Kai-Wen Cheng, Yi-Chen Chen, Kuan-Chen Cheng

Journal of Food and Drug Analysis

This study reveals the anti-tyrosinase activity of Ganoderma formosanum extracts, pinpointing compounds including gluconic acid, mesalamine, L-pyroglutamic acid, esculetin, 5-hydroxyindole, and salicylic acid, as effective melanin production inhibitors in melanoma cells and zebrafish embryos. Furthermore, multiple molecular docking simulations provided insights into interactions between the identified compounds and tyrosinase, increasing binding affinity up to -16.36 kcal/mol. The enhanced binding of identified compounds to tyrosinase facilitated synergistic inhibitory effects on melanin production. This study highlights the potential of GFE-EA as a source of natural tyrosinase inhibitors and contributes to understanding the role of active compounds extracted from G. formosanum.

The Effects Of Fermentation By Different Species Oflactic Acid Bacteria On Betalains And Polyphenol Profile And In Vitro Bioactive Potential Of Red Beetroot Juice, Tomasz Sawicki, Monika Jabłońska, Małgorzata Starowicz, Lucyna Kłębukowska, Wioletta Błaszczak

Journal of Food and Drug Analysis

In the current study, the effects of fermentation by Lactobacillus acidophilus, Levilactobacillus brevis or Lactiplantibacillus plantarum (La/Lb/Lp, 1-2.5%) and incubation (30/37℃, C1/C2) of red beetroot juice on the profile of betalains and polyphenols (UHPLC-DAD-MS), and antioxidant capacity using photochemiluminescence (PCL) and spectrophotometric assays (DPPH/ABTS) was investigated. Additionally, anti-glycaemic (anti-AGEs) and anti-cholinergic (anti-AChE) potential in vitro was analysed. Fermentation distinctly initiated isobetanin and neobetaninformation and enhanced flavonoid concentration, emphasising rutin, kaempferol and (+)-catechin. The fermented juices inhibited protein glycation in the BSA-GLU model and showed high DPPH and ABTS values. LP2.5% juice was the only one indicating anti-AChE potential.

Determination And Validation Of Polycyclic Aromatichydrocarbons (Pah4) In Katsuobushi, Plant-Basedfood Supplements, And Cocoa Bean Shells Using Gc-Ms/Ms, Chia-Hsin Liu, Yu-Ning Shin, Ya-Chun Chou, Guan-Jhih Peng, Ying-Ru Shen, Nu-Ching Lin, Shu-Han Chang, Ya-Min Kao, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

Polycyclic aromatic hydrocarbons (PAHs) are primarily generated through the incomplete combustion or pyrolysis oforganic materials in various industrial processes. Foods may become contaminated with environmental PAHs found inair, soil, or water, or through industrial food processing methods such as smoking, roasting, drying, and grilling. The Ministry of Health and Welfare in Taiwan has established maximum levels for benzo[a]pyrene (BaP) and indicativevalues for BaP as well as PAH4 (the sum of benz[a]anthracene, chrysene, benzo[b]fluoranthene, and benzo[a]pyrene) infoods as operational guidelines. The current study developed an analytical method for simultaneous determination of PAH4 levels in katsuobushi (dried bonito flakes), cocoa bean shells, …

Herbal Nanoemulsions In Cosmetic Science: A Comprehensive Review Of Design, Preparation, Formulation, And Characterization, Benni Iskandar, Ta-Wei Liu, Hui-Ching Mei, I-Chih Kuo, Meircurius Dwi Condro Surboyo, Hsiu-Mei Lin, Ching-Kuo Lee

Journal of Food and Drug Analysis

The rapid development of delivery systems for cosmetics has revealed two critical challenges in the field: enhancing the solubility of active ingredients and ensuring the stability of natural materials used in cosmetics. Nanoemulsion technology has emerged as an indispensable solution for addressing these challenges, not only enhancing the stability of cosmetics but also improving the solubility of pharmaceuticals and active ingredients with poor solubility. Nanoemulsion formulations have reinforced stability and amended the bioavailability of hydrophobic drugs. Moreover, nanoemulsion exhibit excellent skin penetration and long-lasting effects, making them particularly appealing to consumers, especially in the cosmetic industry. This article aims to …

Integrating Image Data Fusion And Resnet Method For Accurate Fish Freshness Classification, Yahya Layth Khaleel, Mustafa Abdulfattah Habeeb, Ghadeer Ghazi Shayea

Iraqi Journal for Computer Science and Mathematics

Fish freshness classification is critical for protecting public health and ensuring efficient economic, regulatory and environmental sustainability. Classifying accurately reduces the risk of foodborne illness, protects product quality, builds consumer trust and supports sustainable resource conservation through waste minimization. However, the traditional methods for determining fish freshness are variable, time consuming and subjective, precluding practical use. This research presents an improved framework that integrates image data fusion and a deep learning ResNet model to differentiate fresh and nonfresh fish. From multiple sources, a comprehensive dataset including 16,640 samples was curated, and data fusion was used to increase the diversity and …

A Mini Review Of Plant Tissue Culture: The Role Of Media Optimization, Growth Regulators In Modern Agriculture, Callus Induction And The Applications, Norrizah Jafaar Sidik, Hasan M. Agha, Abdulmutalib Alabeed Alkamil, Muneer Mohammed Saleh Alsayadi, Amjad Abdulhadi Mohammed

AUIQ Complementary Biological System

Plant tissue culture is an innovative biotechnological approach developed to meet the escalating global demand for agricultural production with enhanced nutritional value. This aseptic, in vitro technique allows for the cultivation of plant cells, tissues, or entire plants under controlled environmental and nutritional conditions, facilitating the generation of genetically identical clones. The method is indispensable in preserving endangered plant species, boosting crop yield and quality, and enabling year-round production of disease-free plants. Central to plant tissue culture is the composition of the growth medium, which must include a precise balance of macronutrients, micronutrients, amino acids, vitamins, and plant growth regulators …

2024 Fall - Commencement Program, Office Of The Registrar, East Tennessee State University

ETSU Commencement Ceremonies and Programs

No abstract provided.

Phase Ii Trial Of Blood-Brain Barrier Permeable Peptide-Paclitaxel Conjugate Ang1005 In Patients With Recurrent High-Grade Glioma, Manmeet Ahluwalia

All Publications

Background: This study is a phase II clinical trial to evaluate the efficacy, safety, and tolerability of the blood-brain barrier (BBB) permeable peptide-paclitaxel conjugate ANG1005 in patients with recurrent high-grade glioma (HGG) (NCT01967810).

Methods: Seventy-three patients were enrolled in 3 separate arms-recurrent glioblastoma (GBM) (Arm 1), bevacizumab refractory GBM (Arm 2), and grade 3 anaplastic gliomas (AGs) (Arm 3). The study was started in October 2013, and the data were locked on September 29, 2017. Safety was evaluated for all three arms (n = 73), and the primary endpoint for Arms 1 and 3 was objective response …

A Constitution Of The Earth, To Save Humanity, Luigi Ferrajoli

Buffalo Law Review

Humanity is facing one of the most dramatic moments in its history. There are several global challenges and problems that are not part of the political agenda of national governments, even though their solution is crucial for the survival of humanity.

Nutritional Composition Of Mucuna Pruriens Var. Utilis (Velvet Bean) Seeds Grown In Nanyumbu District, Tanzania, Florence Boniface, Stephen I. Nnungu, Washa B. Washa

Tanzania Journal of Science

In tropical countries, Mucuna seeds have been utilized to promote better health and ensure a stable food supply. The use of Mucuna pruriens var. utilis seeds in Tanzania has prompted an evaluation of the nutritional composition of two common cultivars grown in the Nanyumbu district. Mucuna seed samples (black-reddish brown and black-greyish) were collected and analyzed for their nutritional content using standard extraction and spectrophotometric techniques. Data analysis was conducted using GraphPad InStat 3.0 software, with a t-test employed to compare means at a 95% confidence level. The results indicated that the differences in nutritional parameters between the black-reddish brown …

Implementation Of A Standardized Screening And Referral Process For Social Determinants Of Health For Families With Children Within Two Rural Health Clinics, Laura Britton Stace

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Abstract

The American Academy of Pediatrics Bright Futures Guidelines recommends social determinants of health (SDOH) screening at well-child checks (WCCs). Social determinants of health are environmental factors, including food accessibility, mental health, and substance use, that can affect quality of life.

Rural health clinics (RHCs) in a county in Virginia did not routinely use a standardized screener to identify pediatric SDOH risks, nor did they have a standardized referral process for identifying SDOH risks. A hospital community needs assessment found that over 20% of the county households were below the federal poverty level. It is estimated that many children in …

The Burden Of Birth: Racialized Margins Of Care In Washington, D.C., Beya D. Hull

Tapestries: Interwoven voices of local and global identities

The United States has shockingly high rates of maternal mortality in which Black women bear a disproportionate burden of pregnancy related deaths. In D.C., the nation's capital, Black women account for 90% of pregnancy associated deaths, despite comprising less than half of the population. This disparity is a result of systemic medical racism, geographical barriers, and a lack of available culturally reverent care. Community-based collectives have emerged to fill in the gaps left by the healthcare system by providing essential services to underserved communities, specifically Black women. These organizations have proven the potential of ‘non-traditional’ healthcare models to change the …

2024 Fall Commencement Program: Winona State University, Winona State University

WSU Commencement Programs

This is the Winona State University Fall 2024 commencement program. Commencement was on Friday, December 13, 2024.